ࡱ>  bjbj?H?H 3]"c]"cn`%  _____sss+&'<s(----.v.@]l j$<u_r..rr__--V)w)w)wrF_-_-)wr)w)wV~-Ь;UT< s l0xs_dqLq6)wq,rdqdqdqQudqdqdqrrrrdqdqdqdqdqdqdqdqdq %: HYPERLINK \l "GUIDELINES"Guidelines for Preparing P01 Research Project Review Reports HYPERLINK \l "INSTRUCTIONS"Instructions for Using the Critique Template Individual Research Project Critique Template Program Project Application #: Project Leader(s): Overall Impact OF PROJECT  HYPERLINK \l "OVERALL2" Overall Impact of Project: Please limit text to page Scored Review Criteria Consider each of the five review criteria below in the determination of scientific and technical merit, and give a separate score for each in IAR. A research project does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field. 1.  HYPERLINK \l "SIGNIFICANCE2" Significance: Please limit text to page Strengths Weaknesses  2.  HYPERLINK \l "INVESTIGATOR2" Investigator(s): Please limit text to page Strengths Weaknesses  3.  HYPERLINK \l "INNOVATION2" Innovation: Please limit text to page Strengths Weaknesses  4.  HYPERLINK \l "APPROACH2" Approach: Please limit text to page Strengths Weaknesses  5.  HYPERLINK \l "ENVIRONMENT2" Environment: Please limit text to page Strengths Weaknesses  6. Interdependence: Please limit text to page Strengths Weaknesses  Additional Review Criteria The following review criteria are not scored individually, but should be considered when determining the overall impact score. HYPERLINK \l "HUMANS2"Protections for Human Subjects  FORMDROPDOWN  Comments (Required Unless Not Applicable):  FORMTEXT       Data and Safety Monitoring Plan (Applicable for Clinical Trials Only):  FORMDROPDOWN  Comments (Required Unless Not Applicable):  FORMTEXT       HYPERLINK \l "INCLUSION2"Inclusion of Women, Minorities and Children  FORMDROPDOWN   FORMDROPDOWN   FORMDROPDOWN  Comments (Required if Unacceptable):  FORMTEXT  HYPERLINK \l "ANIMALS2"Vertebrate Animals  FORMDROPDOWN  Comments (Required if Unacceptable):  FORMTEXT  HYPERLINK \l "BIOHAZARDS2"Biohazards  FORMDROPDOWN  Comments (Required if Unacceptable):  FORMTEXT   HYPERLINK \l "RESUBMISSION2" Resubmission Comments (if applicable):   HYPERLINK \l "RENEWAL2" Renewal Comments (if applicable):   HYPERLINK \l "REVISION2" Revision Comments (if applicable):  Additional Review Considerations The impact score should not be affected by the following considerations HYPERLINK \l "BUDGET2"Budget and Period of Support  FORMDROPDOWN  Recommended budget modifications or possible overlap identified:  FORMTEXT       HYPERLINK \l "SELECTAGENTS2"Select Agents  FORMDROPDOWN  Comments (Required if Unacceptable):  FORMTEXT       HYPERLINK \l "FOREIGN2"Applications from Foreign Organizations  FORMDROPDOWN  Comments (Required Unless Not Applicable):  FORMTEXT       Authentication of Key Biological and/or Chemical Resources Please limit text to page  HYPERLINK \l "SHARING2"Resource Sharing Plans  FORMDROPDOWN  Comments (Required if Unacceptable):  FORMTEXT      Additional Comments to Applicant HYPERLINK \l "ADDCOM2"Additional Comments to Applicant (Optional) GUIDELINES AND CRITIQUE TEMPLATE FOR PREPARING PROGRAM PROJECT REVIEW REPORTS ( HYPERLINK \l "BEGIN" return to template) Research Objectives The program project mechanism is designed to support research in which the funding of several interdependent projects offers significant scientific advantages over support of these same projects as individual regular research grants. NIGMS supports research in the broad areas of Cell Biology and Biophysics; Genetics and Developmental Biology; Pharmacology, Physiology, and Biological Chemistry; and Bioinformatics and Computational Biology. Program project grants are investigator-initiated, but are restricted to areas of special interest to the individual divisions within NIGMS. For scientific areas of interest to NIGMS, see:  HYPERLINK "http://www.nigms.nih.gov/About/overview" http://www.nigms.nih.gov/About/overview For NIGMS Program Project funding policies and applicant guidance, see:  HYPERLINK "http://www.nigms.nih.gov/Research/Application/ProgProjFundPolicies.htm" www.nigms.nih.gov/Research/Application/ProgProjFundPolicies.htm Successful program projects generally bring together scientists in diverse fields, who would not otherwise collaborate, to apply complementary approaches to work on an important well-defined problem. Since it is not unusual for principal investigators of individual research grants to share techniques, information, and methods, it is not sufficient that the projects are unified by a common theme. In this regard the burden of proof is on the principal investigator, and on each individual project leader, to demonstrate in the written application that the program would be much less effective if parceled out as a set of independent research grants. In addition, the program project can facilitate the support of essential shared core facilities, e.g., major equipment, although the need of a group of investigators for a major piece of equipment or a core facility does not in itself justify a program project grant. Administrative cores, except in special, well-justified circumstances, will not be allowed. Further, it is expected that successful program projects will establish effective collaborations, particularly in emerging areas of research, that extend beyond the life of the program project grant itself. Hence, a program project generally has a finite lifetime. Normally, a program project consists of three to five individual interdependent projects from different investigators. The scientist designated by the applicant institution as the principal investigator bears responsibility for the overall scientific leadership and fiscal management of the program project grant. It is expected that each of the collaborating scientists responsible for the individual projects will be independent investigators. Investigators from more than one department, administrative unit, or institution (through a subcontract mechanism) are commonly included. The program project grant is not intended to be a vehicle for departmental support, nor is the research support of a single senior investigator and several postdoctoral and research associate-level scientists appropriate under this mechanism. In addition, the program project and each individual project must represent a significant effort on the part of the participating scientists and be distinct from their other funded efforts. If individuals have substantial support in areas closely related to the program project, their support should be folded into the program project. If their support cannot be folded in, they may participate as associate members. Associate members have full use of, for example, core facilities, and contribute to the overall collegiality of the project, but derive no financial support from it. See the complete NIH Program Announcement for more details:  HYPERLINK "http://grants.nih.gov/grants/guide/pa-files/PA-07-030.html" http://grants.nih.gov/grants/guide/pa-files/PA-07-030.html ( HYPERLINK \l "BEGIN" return to template) Using the Critique Template Research Projects should be evaluated using the criteria listed in the critique template emphasizing those aspects that are most important for each project. Use the critique template to organize your comments regarding the research project. Use Ctrl+Click (or Command+Click for Mac) on each review criteria to see examples of specific items you should consider. ( HYPERLINK \l "BEGIN" return to template) Written Critiques For individual research projects, Scored Review Criteria and Additional Review Criteria are represented in the reviewer critique template and should be commented on, listing the strengths and weaknesses of each. Avoid descriptive material that distracts from your assessment. The goal is to provide the most evaluative and pertinent information in a concise minor. However, the text boxes will expand as needed. Consider each of the Scored Review Criteria to assess their merit for this research project and give a separate score (1 to 9) for each in Internet Assisted Review (IAR). These individual criterion scores are considered part of your critique and need not be discussed at the review meeting. They may be changed in the EDIT phase in IAR. An application does not need to be strong in all categories to be judged likely to have major impact. Assigned reviewers must upload critiques before entering an overall impact/priority score. While Discussants are not required to prepare full written critiques, brief comments in the Overall Impact text box on the key strengths and weaknesses of the project are encouraged. After considering all of the review criteria, briefly summarize the strengths and weaknesses of the project in the Overall Impact section of the template and provide a budget recommendation in the Budget section. Preliminary Scores Using IAR, reviewers provide both a preliminary Overall Impact score (formerly called priority score) and Criterion Scores (i.e., numerical ratings of each of the Scored Review Criteria). Ratings are provided only in whole numbers, not decimals. Briefly, scores in the range of 1 to 3 = high impact, 4 to 6 = moderate impact, and 7 to 9 = low impact. Scored criterion scores can only be submitted after your critique has been uploaded into IAR. The criterion scores will appear in the summary statement as part of your critique. Please do not write your criterion scores on the critique template itself. The criterion scores may be changed during FINAL SCORING on your electronic or paper Voter/Scoring Sheet, or following the review meeting during the EDIT phase. Detailed scoring guidance can be found in the Meeting Materials section of IAR or online at:  HYPERLINK "http://grants.nih.gov/grants/peer/guidelines_general/scoring_system_and_procedure_a5.pdf" http://grants.nih.gov/grants/peer/guidelines_general/scoring_system_and_procedure_a5.pdf ( HYPERLINK \l "BEGIN" return to template) ****************************************************************************************************` Items for Consideration Overall Impact (HYPERLINK \l "OVERALL1"return) Reviewers are asked to provide an overall impact/priority score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the five core review criteria, and the additional review criteria (as applicable for the project proposed). Briefly summarize the major Strengths and Weaknesses of the application that led to your recommended Overall Impact score. Significance (HYPERLINK \l "SIGNIFICANCE1"return) Does the project address an important problem or a critical barrier to progress in the field? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field? Investigator(s) (HYPERLINK \l "INVESTIGATOR1"return) Are the PD/PIs, collaborators, and other researchers well suited to the project? If Early Stage Investigators or New Investigators, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD/PI, do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project? Innovation (HYPERLINK \l "INNOVATION1"return) Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed? Approach (HYPERLINK \l "APPROACH1"return) Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the project? Are potential problems, alternative strategies, and benchmarks for success presented? If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be managed? If the project involves clinical research, are the plans for 1) protection of human subjects from research risks, and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the scientific goals and research strategy proposed? Environment (HYPERLINK \l "ENVIRONMENT1"return) Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements? Protections for Human Subjects (HYPERLINK \l "HUMANS1"return) For research that involves human subjects but does not involve one of the six categories of research that are exempt under 45 CFR Part 46 (as described in  HYPERLINK "http://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Protection_and_Inclusion_a5.pdf" Human Subjects Protection and Inclusion) , reviewers are asked to evaluate the justification for involvement of human subjects and the proposed protections from research risk relating to their participation according to the following five review criteria: 1) risk to subjects, 2) adequacy of protection against risks, 3) potential benefits to the subjects and others, 4) importance of the knowledge to be gained, and 5) data and safety monitoring for clinical trials. If all of the criteria are adequately addressed, and there are no concerns, write "Acceptable Risks and/or Adequate Protections." A brief explanation is advisable. If one or more criteria are inadequately addressed, write, "Unacceptable Risks and/or Inadequate Protections" and document the actual or potential issues that create the human subjects concern. Also, if a clinical trial is proposed, evaluate the Data and Safety Monitoring Plan. (If the plan is absent, notify the SRO immediately to determine if the application should be withdrawn.) Indicate if the plan is "Acceptable" or "Unacceptable", and, if unacceptable, explain why it is unacceptable. For research that involves human subjects and meets the criteria for one or more of the six categories of research that are exempt, evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials. If the claimed exemption is not justified, indicate Unacceptable, and, if unacceptable, explain why it is unacceptable. NOTE: To the degree that acceptability or unacceptability affects the investigator's approach to the proposed research, such comments should appear under "Approach" in the five major review criteria above, and should be factored into the score as appropriate. For additional information to assist you in making these determinations, please refer to  HYPERLINK "http://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Protection_and_Inclusion.pdf" http://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Protection_and_Inclusion.pdf and  HYPERLINK "http://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Worksheet.pdf" http://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Worksheet.pdf Inclusion of Women, Minorities and Children (HYPERLINK \l "INCLUSION1"return) When the proposed project involves clinical research, reviewers are asked to evaluate the proposed plans for inclusion of minorities and members of both genders, as well as the inclusion of children. Public Law 103-43 requires that women and minorities must be included in all NIH-supported clinical research projects involving human subjects unless a clear and compelling rationale establishes that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. NIH requires that children (individuals under the age of 21) of all ages be involved in all human subjects research supported by the NIH unless there are scientific or ethical reasons for excluding them. Each project involving human subjects must be assigned a code using the categories "1" to "5" below. Category 5 for minority representation in the project means that only foreign subjects are in the study population (no U.S. subjects). If the study uses both then use codes 1 thru 4. Examine whether the minority and gender characteristics of the sample are scientifically acceptable, consistent with the aims of the project, and comply with NIH policy. For each category, determine if the proposed subject recruitment targets are "A" (acceptable) or "U" (unacceptable). If you rate the sample as "U", consider this feature a weakness in the research design and reflect it in the overall score. Explain the reasons for the recommended codes; this is particularly critical for any item coded "U". NOTE: To the degree that acceptability or unacceptability affects the investigator's approach to the proposed research, such comments should appear under "Approach" in the five major review criteria above, and should be factored into the score as appropriate. For additional information to assist you in making these determinations, please refer to  HYPERLINK "http://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Protection_and_Inclusion.pdf" http://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Protection_and_Inclusion.pdf and  HYPERLINK "http://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Worksheet.pdf" http://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Worksheet.pdf Gender Inclusion Code G1 = Both genders G2 = Only women G3 = Only men G4 = Gender composition unknown Minority Inclusion Code M1 = Minority and nonminority M2 = Only minority M3 = Only nonminority M4 = Minority composition unknown M5 = Only foreign subjects Children Inclusion Code C1 = Children and adults C2 = Only children C3 = No children included C4 = Representation of children unknown Vertebrate Animals (HYPERLINK \l "ANIMALS1"return) Reviewers are asked to evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following five points: 1) proposed use of the animals, and species, strains, ages, sex, and numbers to be used; 2) justifications for the use of animals and for the appropriateness of the species and numbers proposed; 3) adequacy of veterinary care; 4) procedures for limiting discomfort, distress, pain and injury to that which is unavoidable in the conduct of scientifically sound research including the use of analgesic, anesthetic, and tranquilizing drugs and/or comfortable restraining devices; and 5) methods of euthanasia and reason for selection if not consistent with the AVMA Guidelines on Euthanasia. For additional information to assist you in determining if the Vertebrate Animals section is Acceptable or Unacceptable, please refer to:  HYPERLINK "http://grants.nih.gov/grants/olaw/VASchecklist.pdf" http://grants.nih.gov/grants/olaw/VASchecklist.pdf Biohazards (HYPERLINK \l "BIOHAZARDS1"return) Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed. Resubmission Applications ( HYPERLINK \l "RESUBMISSION1" return) When reviewing a Resubmission application (formerly called an amended application), evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project. Renewal Applications ( HYPERLINK \l "RENEWAL1" return) When reviewing a Renewal application (formerly called a competing continuation application), the committee will consider the progress made in the last funding period. Revision Applications (HYPERLINK \l "REVISION1"return) When reviewing a Revision application (formerly called a competing supplement application), the committee will consider the appropriateness of the proposed expansion of the scope of the project. If the Revision application relates to a specific line of investigation presented in the original application that was not recommended for approval by the committee, then the committee will consider whether the responses to comments from the previous scientific review group are adequate and whether substantial changes are clearly evident. Budget and Period Support (HYPERLINK \l "BUDGET1"return) Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research. Select Agents (HYPERLINK \l "SELECTAGENTS1"return) Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s). Select agent information is available via  HYPERLINK "http://grants.nih.gov/grants/policy/select_agent/" http://grants.nih.gov/grants/policy/select_agent/ Applications from Foreign Organization (HYPERLINK \l "FOREIGN1"return) Reviewers will assess whether the project presents special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions that exist in other countries and either are not readily available in the United States or augment existing U.S. resources. Resource Sharing Plans (HYPERLINK \l "SHARING1"return) Reviewers will comment on whether the following Resource Sharing Plans, or the rationale for not sharing the following types of resources, are reasonable: 1) Data Sharing Plan (http://grants.nih.gov/grants/policy/datasharing/datasharingguidance.htm) Applications requesting more than $500,000 direct costs in any year of the proposed research are expected to include a data sharing plan in their application. Certain Program Announcements may request a data sharing plan for all applications regardless of the amount of direct costs. Assess the reasonableness of the data sharing plan or the rationale for not sharing research data. 2) Sharing Model Organisms (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-04-042.html). All NIH grant applications are expected to include a description of a specific plan for sharing and distributing unique model organism research resources generated using 6LYZ[\xyz𽫽xjWK=hE^0JCJOJQJaJhE^0JOJQJ^J$hh0JCJOJQJ^JaJhwhs;0J5CJaJ(hb,hs;0JCJKHOJQJ^JaJ$jwh0J5CJUaJhs;0J5CJaJ"hs;0JCJKHOJQJ^JaJ(hy hs;0JCJKHOJQJ^JaJ$jh0J5CJUaJh0J5CJaJjhs;0J5CJUaJ[ &  O (`$IfYD(gdgds (`YD(gdE^$0`XDYD(a$gdE^$  0`XDYD(a$gdE^  0`XDYD(^gds;   % & ' A B C \ ] ^ _ Իp_N_D8hE^CJOJQJ^JhE^OJQJaJ h RhCJOJQJ^JaJ hhE^CJOJQJ^JaJh5CJOJQJ^JaJ$h]FhE^0JCJOJQJ^JaJ/jh]FhCJOJQJU^JaJ h]FhCJOJQJ^JaJ)jh]FhCJOJQJU^JaJh(Rg h;dh;dhE^>*OJQJ^JhE^hE^OJQJ^JhE^0JOJQJ^J (`$IfYD(gdHVikde$$Ifl%% t 0%44 layt;d  ^ r O (`$IfYD(gd^gdv:gdslkd$$Ifl4%% t 0%44 laf4yt;d & - 2 C  * + , 8 9 : ; ѳiVD3 hhE^CJOJQJ^JaJ#hhE^5CJOJQJ^JaJ$h]FhE^0JCJOJQJ^JaJ/juh]FhCJOJQJU^JaJ h]FhCJOJQJ^JaJ)jh]FhCJOJQJU^JaJhE^CJOJQJ^J hRhE^CJOJQJ^JaJhjhv:OJQJ^JhjhsOJQJ^JhjhSOJQJ^JhE^ h Rh;dhE^OJQJaJ; ] ^ _ h i k u v w x y | } ̺̺٬u]J9 h]FhCJOJQJ^JaJ$h]FhE^0JCJOJQJ^JaJ/jh]FhCJOJQJU^JaJ h]FhCJOJQJ^JaJ)jh]FhCJOJQJU^JaJ h]FhE^CJOJQJ^JaJhE^CJOJQJ^JaJ#hhE^5CJOJQJ^JaJhE^5CJOJQJ^JhE^OJQJaJhE^CJOJQJ^J h RhCJOJQJ^JaJ^ _ i k v w || & F(`$IfYD( (`$IfYD(gkd$$Ifl4%% t 044 laf4ytE^w x y }q O x$If O (`$IfYD(gd (`YD(gdE^dkd}$$Ifl%% t 044 laytE^        綥~mU~B~1 hhE^CJOJQJ^JaJ$h]FhE^0JCJOJQJ^JaJ/jh]FheuCJOJQJU^JaJ h]FheuCJOJQJ^JaJ)jh]FheuCJOJQJU^JaJ#hhE^5CJOJQJ^JaJ hRhE^CJOJQJ^JaJhE^CJOJQJ^JaJ h]FhE^CJOJQJ^JaJ#h]FhE^5CJOJQJ^JaJhE^OJQJaJh]FhE^CJOJQJ^J || & F(`$IfYD( (`$IfYD(gkd$$Ifl4%% t 044 laf4ytE^ B C }q O x$If O (`$IfYD(gd (`YD(gdE^dkd $$Ifl%% t 044 laytE^ A B C D N P [ \ ] ^ ` a b } ~  ñͱ͑͢|kS|@|$h]FhE^0JCJOJQJ^JaJ/jh]FheuCJOJQJU^JaJ h]FheuCJOJQJ^JaJ)jh]FheuCJOJQJU^JaJ hRhE^CJOJQJ^JaJhhE^CJOJQJaJ#hhE^5CJOJQJ^JaJhE^OJQJaJ hhE^CJOJQJ^JaJ hhCJOJQJ^JaJ h RhCJOJQJ^JaJC D N P [ \ || & F(`$IfYD( (`$IfYD(gkd$$Ifl4%% t 044 laf4ytE^\ ] ^ } O (`$IfYD(gd (0YDgdE^dkd$$Ifl%% t 044 laytE^  & F(`$IfYD( (`$IfYD(dkd$$Ifl%% t 044 laytE^     ) + 6 7 8 ܼ~kZI??hE^OJQJaJ h#h#CJOJQJ^JaJ h Rh#CJOJQJ^JaJ$h]FhE^0JCJOJQJ^JaJ/jh]FheuCJOJQJU^JaJ h]FheuCJOJQJ^JaJ)jh]FheuCJOJQJU^JaJ hRhE^CJOJQJ^JaJh#hE^CJOJQJaJ h#hE^CJOJQJ^JaJ#h#hE^5CJOJQJ^JaJ   zn O x$If O (`$IfYD(gd# (`YD(gdE^gkd$$Ifl4%% t 044 laf4ytE^  ) + 6 7  & F(`$IfYD( (`$IfYD(dkd $$Ifl%% t 044 laytE^7 8 9 p q zk O x$Ifgdg| O (`$IfYD(gdg| (`YD(gdE^gkd $$Ifl4%% t 044 laf4ytE^8 9 : ; < K M o q r | ~ 伪~~mYE3#hlCh;d5CJOJQJ^JaJ&h;dh;d5;CJOJQJ^JaJ&h;dhE^5;CJOJQJ^JaJ hME5;CJOJQJ^JaJhMEOJQJaJ h#hMECJOJQJ^JaJ h RhMECJOJQJ^JaJ#h#hME5CJOJQJ^JaJ,h{hME>*B*CJOJQJ^JaJph hRhMECJOJQJ^JaJhMECJOJQJ^JaJhE^CJOJQJ^JaJq r | ~ yy & F(`$IfYD(gdg|(`$IfYD(gdg|dkd( $$Ifl%% t 044 laytg| R@|rk__ (`$IfYD(Pgdl@ $Pa$gd;d $(`YD(a$gdE^ $(`YD(a$gd;dgkd $$Ifl4%% t 044 laf4ytg| BPRTBϺugRuA0 hi=hE^CJOJQJ^JaJ hw!hE^CJOJQJ^JaJ)j hw!CJOJQJU^JaJhw!CJOJQJ^JaJ#jhw!CJOJQJU^JaJh Rhl@0JCJaJ/j8 h Rhl@CJOJQJU^JaJhl@CJOJQJ^JaJ)jh Rhl@CJOJQJU^JaJhl@5CJOJQJ^JaJh;d5CJOJQJ^JaJ#h Rh;d5CJOJQJ^JaJBDXZ\fhrtْo^F7hlChE^CJOJQJ^J/jhi=hE^CJOJQJU^JaJ hw!hE^CJOJQJ^JaJ)j hw!CJOJQJU^JaJhw!CJOJQJ^JaJ#jhw!CJOJQJU^JaJ8jhi=hE^CJOJPJQJU^JaJmHnHu/jC hi=hE^CJOJQJU^JaJ hi=hE^CJOJQJ^JaJ)jhi=hE^CJOJQJU^JaJ@jrWLL (`YD(gdl@lkd$$Ifl4%% t 0%44 laf4ytl@ & F(`$IfYD((`$IfYD(^ (`$IfYD( & F(`$IfYD(0268TVXZ\ڭŠڋzbQ<)jh|Xsh aCJOJQJU^JaJ h ahE^CJOJQJ^JaJ/jh ah aCJOJQJU^JaJ h ah aCJOJQJ^JaJ)jh ah aCJOJQJU^JaJh Rhl@0JCJaJ/j"h Rhl@CJOJQJU^JaJ)jh Rhl@CJOJQJU^JaJhl@CJOJQJ^JaJhSCJOJQJ^JaJhE^OJQJaJ6Z  >PuqjjjPgdl@ikd$$Ifl%% t 0%44 laytl@ & F(`$IfYD( (`$IfYD(xYD2gdS \xz|±sbMb5M/jihHhE^CJOJQJU^JaJ)jhHhE^CJOJQJU^JaJ hHhE^CJOJQJ^JaJ/j h|Xsh|XsCJOJQJU^JaJ h|Xsh|XsCJOJQJ^JaJ)jh|Xsh|XsCJOJQJU^JaJ h|XshE^CJOJQJ^JaJ)jh|Xsh aCJOJQJU^JaJ/jah|Xsh aCJOJQJU^JaJ h|Xsh aCJOJQJ^JaJ    ()*<=>?MùpcN= h ah aCJOJQJ^JaJ)jh ah aCJOJQJU^JaJh Rhl@0JCJaJ/jbh Rhl@CJOJQJU^JaJ)jh Rhl@CJOJQJU^JaJhl@CJOJQJ^JaJhSCJOJQJ^JaJhE^OJQJaJ hHhE^CJOJQJ^JaJ)jhHhE^CJOJQJU^JaJ+hHhE^CJOJQJ^JaJmHnHuMNOPvwmcUG2G)jh Rhl@CJOJQJU^JaJhl@CJOJQJ^JaJhSCJOJQJ^JaJhE^OJQJaJ+hHhE^CJOJQJ^JaJmHnHu/jhHhE^CJOJQJU^JaJ)jhHhE^CJOJQJU^JaJ hHhE^CJOJQJ^JaJ h ahE^CJOJQJ^JaJ)jh ah aCJOJQJU^JaJ/jh ah aCJOJQJU^JaJu|||pp (`$IfYD(Pgdl@lkd$$Ifl4%% t 0%44 laf4ytl@ & F(`$IfYD(ҷyhWBW*B/jhi=hE^CJOJQJU^JaJ)jhi=hE^CJOJQJU^JaJ hi=hE^CJOJQJ^JaJ h ahE^CJOJQJ^JaJ/jh ah aCJOJQJU^JaJ h ah aCJOJQJ^JaJ)jh ah aCJOJQJU^JaJhl@CJOJQJ^JaJh Rhl@0JCJaJ)jh Rhl@CJOJQJU^JaJ/jh Rhl@CJOJQJU^JaJ&'(457STUVpqrùvcT?)j!hdMCJOJQJU^JaJhi=hE^CJOJQJaJ$hl@hdM0JCJOJQJ^JaJ)j hdMCJOJQJU^JaJ#jhdMCJOJQJU^JaJhdMCJOJQJ^JaJhSCJOJQJ^JaJhE^OJQJaJ hi=hE^CJOJQJ^JaJ)jhi=hE^CJOJQJU^JaJ+hi=hE^CJOJQJ^JaJmHnHu7QSl & F(`$IfYD(gd a (`$IfYD( (`YD(gddMikd0 $$Ifl%% t 0%44 laytl@STU}|l & F(`$IfYD( (`$IfYD( (`YD(gdE^lkd2!$$Ifl4%% t 0%44 laf4ytl@ryz{|}Ϳͮ|kS|@|/ hi=h1gCJOJQJ^JaJ$h}h}0JCJOJQJ^JaJ/j"h}h}CJOJQJU^JaJ h}h}CJOJQJ^JaJ)jh}h}CJOJQJU^JaJh}CJOJQJ^JaJhi=hE^CJOJQJaJ hi=hE^CJOJQJ^JaJhSCJOJQJ^JaJhdMCJOJQJ^JaJ#jhdMCJOJQJU^JaJ$hdMhdM0JCJOJQJ^JaJyf & F(`$IfYD(gdl@(`$IfYD(gdl@ (0YDgdE^lkd0"$$Ifl4%% t 0%44 laf4ytl@*{rcc(`$IfYD(gd[pxPgdS$a$gd#gds (0YDgdE^lkd0#$$Ifl4%% t 0%44 laf4yt}$ѿr_M?h" CJOJQJ^JaJ#jh" CJOJQJU^JaJ$h" h" 0JCJOJQJ^JaJ/j#h" h" CJOJQJU^JaJ h" h" CJOJQJ^JaJ)jh" h" CJOJQJU^JaJhS5CJOJQJ^JaJ#h#h#5CJOJQJ^JaJ h#h;d h#hE^hSh1gCJOJQJ^JaJhi=h1gCJOJQJaJ$&(Dzǚq\K3\/jv&h" h" CJOJQJU^JaJ h" h" CJOJQJ^JaJ)jh" h" CJOJQJU^JaJh" CJOJQJ^JaJ4jh Rh" CJOJQJU^JaJmHnHu/jt%h Rh" CJOJQJU^JaJ)jh Rh" CJOJQJU^JaJ h Rh" CJOJQJ^JaJ#jh" CJOJQJU^JaJ)j,$h" CJOJQJU^JaJ:^~yyrcc(`$IfYD(gd[pPgd" gd" jkd%$$Ifl%% t 0644 layt[p & F (`$IfYD(gd" 68:<XZ\ ǵlTl9l4jh Rh" CJOJQJU^JaJmHnHu/j'(h Rh" CJOJQJU^JaJ)jh Rh" CJOJQJU^JaJ h Rh" CJOJQJ^JaJ)j&h" CJOJQJU^JaJh" CJOJQJ^JaJ#jh" CJOJQJU^JaJ h" h" CJOJQJ^JaJ)jh" h" CJOJQJU^JaJ$h" h" 0JCJOJQJ^JaJ`wwa & F (`$IfYD(gd" (`$IfYD(gd[pPgd" gd" lkd($$Iflm%% t 0644 layt[p  \^`b~ҿҮyhSh;S/j*h Rh" CJOJQJU^JaJ)jh Rh" CJOJQJU^JaJ h Rh" CJOJQJ^JaJ)j)h" CJOJQJU^JaJh" CJOJQJ^JaJ#jh" CJOJQJU^JaJ h" h" CJOJQJ^JaJ$h" h" 0JCJOJQJ^JaJ)jh" h" CJOJQJU^JaJ/j7)h" h" CJOJQJU^JaJ ~п{{cRF8hSCJOJQJ^JaJh)SCJOJQJ^J hh)SCJOJQJ^JaJ/ *h)Sh)S>*B*CJOJQJ^JaJphh)SCJOJQJ^JaJ h Rh)SCJOJQJ^JaJ,hyh)S>*B*CJOJQJ^JaJphh" CJOJQJ^JaJ h Rh" CJOJQJ^JaJ)jh Rh" CJOJQJU^JaJ4jh Rh" CJOJQJU^JaJmHnHu  $Ifgd)Sgd" jkdl+$$Ifl%% t 0644 layt[p(`$IfYD(gd\_ikd+$$Ifl%% t 0%44 layt\_Fjxxb & F (`$IfYD(gd" (`$IfYD(gd[pPgd" gd" lkdk,$$Ifl4%% t 0%44 laf4yt\_BDFHdfhٜyhSh;S/j.h Rh" CJOJQJU^JaJ)jh Rh" CJOJQJU^JaJ h Rh" CJOJQJ^JaJ)ji-h" CJOJQJU^JaJh" CJOJQJ^JaJ#jh" CJOJQJU^JaJ$h" h" 0JCJOJQJ^JaJ/j,h" h" CJOJQJU^JaJ h" h" CJOJQJ^JaJ)jh" h" CJOJQJU^JaJ)*+KL[\]^iпvcUD@1hs;5CJOJQJ^JaJhs; h:hs;CJOJQJ^JaJh" CJOJQJ^JaJ$h" h" 0JCJOJQJ^JaJ/j/h" h" CJOJQJU^JaJ h" h" CJOJQJ^JaJ)jh" h" CJOJQJU^JaJh" h Rh" h Rh" CJOJQJ^JaJ)jh Rh" CJOJQJU^JaJ4jh Rh" CJOJQJU^JaJmHnHuX| O (`$IfYD(gd[pgd" jkd9/$$Ifl%% t 0644 layt[pXYZ~ & F (`$IfYD(gd" jkd$0$$Ifl$% t 0644 layt[pZ[\^>onnnnnnnxx]^gds;$]^a$gds;gd" jkd0$$Ifl$% t 0644 layt[p ijlmnop|ϽuddddQdd$hVhs;0JCJOJQJ^JaJ hwhs;CJOJQJ^JaJ#hwhs;5CJOJQJ^JaJ$hXhs;0JCJOJQJ^JaJ)j1hs;CJOJQJU^JaJhs;CJOJQJ^JaJ#jhs;CJOJQJU^JaJhs;5CJOJQJ^JaJ#h]hs;5CJOJQJ^JaJh5CJOJQJ^JaJ/npqB)C)))))))** * * *"*#*$*6*7*ϼ򮜮xiTA$hXhs;0JCJOJQJ^JaJ)j1hs;CJOJQJU^JaJhs;5CJOJQJ^JaJ$hwnhB0JCJOJQJ^JaJ hR@hBCJOJQJ^JaJ#jhBCJOJQJU^JaJhBCJOJQJ^JaJ$hVhs;0JCJOJQJ^JaJ#jhs;CJOJQJU^JaJ hwhs;CJOJQJ^JaJhs;CJOJQJ^JaJ#C)))* *:*W*X*++,--`/gdY? & FgdY?gds; xx7$8$H$^gds; ]^gds;$a$gds;$ ]^a$gds;xx]^gdBxx]^gds;7*;*D*E*V*W*X*j*******+H+J+x++++++ϻ|e|QeeQ?#jhs;CJOJQJU^JaJ&hs;5B*CJOJQJ^JaJphJD*,hrhs;5B*CJOJQJ^JaJphJD*&h+5B*CJOJQJ^JaJphJD*,hrhY?5B*CJOJQJ^JaJphJD*&hY?5B*CJOJQJ^JaJphJD*&h -hs;5>*CJOJQJ^JaJ"h -hs;5>*CJOJQJ^Jhs;5>*CJOJQJ^Jhs;5CJOJQJ^JaJ+++++++,,,,-r-s--------˸˩oZooI44)hvThY?B* CJOJQJ^JaJph h -hY?CJOJQJ^JaJ)h4hY?B* CJOJQJ^JaJph)h -hY?B* CJOJQJ^JaJph#hY?B* CJOJQJ^JaJph%hQ8hs;B* CJOJQJ^Jphhs;5CJOJQJ^JaJ$hXhs;0JCJOJQJ^JaJ#jhs;CJOJQJU^JaJ)j1hs;CJOJQJU^JaJhs;CJOJQJ^JaJ----P....._/a///\0d0s0t0u0v0001%1I1L1휊uu`KKK`)hQ8hY?B* CJOJQJ^JaJph)hQ8hY?B* CJOJQJ^JaJph)h[`hY?B* CJOJQJ^JaJph#hY?B* CJOJQJ^JaJph)hG}hY?B* CJOJQJ^JaJph)hvThY?B* CJOJQJ^JaJph#h+B* CJOJQJ^JaJph)h -hY?B* CJOJQJ^JaJph#hY?B* CJOJQJ^JaJph`/a///u0v0L1M1`1a12233c4d4455 $(`YD(a$gds; & F7$8$H$gds; 7$8$H$^gdY? & F7$8$H$gdY? 7$8$H$gds;gds;gdY? & FgdY?gdY?L1M1`1a1t33333b4d4444'5)5*55555ųxcxPxAhs;5CJOJQJ^JaJ$hZhs;0JCJOJQJ^JaJ)hOhs;B* CJOJQJ^JaJph,jhs;B* CJOJQJU^JaJphh5hY?B*CJ^Jph)h5hY?B* CJOJQJ^JaJph#hY?B* CJOJQJ^JaJph#hs;B* CJOJQJ^JaJph%hQ8hs;B* CJOJQJ^Jph)h -hs;B* CJOJQJ^JaJph55555555663646C6D6E6gQC0$j *hh0JOJQJU *hhOJQJh+ *hhB* CJOJQJ^Jhph/hNh>*B* CJOJQJ^JaJhph,hNhB* CJOJQJ^JaJhph#hs;B* CJOJQJ^JaJphhs;5CJOJQJ^JaJ$hXhs;0JCJOJQJ^JaJ)j_2hs;CJOJQJU^JaJhs;CJOJQJ^JaJ#jhs;CJOJQJU^JaJ55646C6h6-8:8d899%:#<.</<W<?>@>xgdSxgdSgdxgdxgdsgdxgdxgd $xa$gd $(`YD(a$gds;xx7$8$H$^`gds;E6]6^6_6e6f6h677,8-898:8;8<8Y8Ⱥr`XL;2hOJQJh jh hOJQJUhh hOJQJhh2!hh"hB* CJOJQJ^Jhph-hhB* CJOJPJQJ^JaJph/ *hhB* CJOJQJ^JaJhph0 *hhB* CJOJPJQJ^JaJph *hhOJQJh$j *hh0JOJQJU*j2 *hh0JOJQJU *hh0JOJQJY8Z8[8a8b8c8d8999999999:|gU@.۸"hB* OJPJQJ^Jhph(hhhB* OJPJQJ^Jhph"hB* OJPJQJ^Jhph(hhB* OJPJQJ^Jhph#hB* CJOJQJ^JaJph)hhB* CJOJQJ^JaJph)hshsB* CJOJQJ^JaJphhOJQJhh hOJQJhh h0JOJQJh jh hOJQJUh&j?3h hOJQJUh:::":#:$:%:"<#<-<.</<0<1<L<M<N<|qjSD*S2j94h h>*B*OJQJUhphh>*B*OJQJhph,jh h>*B*OJQJUhph hhhhhOJQJ"hB* OJPJQJ^Jhph)h hB* CJOJQJ^JaJph)h1gh1gB* CJOJQJ^JaJphhOJQJhh hOJQJhh h0JOJQJh jh hOJQJUh&j3h hOJQJUhN<T<U<V<W<>>?>@>I>J>K>d>e>f>l>m>n>o>@qW>0hhB* CJOJPJQJ^JaJhph2j4h h>*B*OJQJUhphh>*B*OJQJhph"hB* OJPJQJ^Jhph*hB* CJOJPJQJ^JaJhph0h hB* CJOJPJQJ^JaJhphhOJQJhh hOJQJh,jh h>*B*OJQJUhph#h h>*B*OJQJhph@>I>o>@A/ABBBC D^H_HIIJJ@KLLLLMMMRgdxgdgdxgdxgd@AAAA$A%A&A,A-A.A/ABBBBBBBͶ{r]L]>ͶhB* CJOJQJph h;hCJOJQJ^JaJ)h;hB* CJOJQJ^JaJphhOJQJh#h h>*B*OJQJhph2j'5h h>*B*OJQJUhphh>*B*OJQJhph,jh h>*B*OJQJUhphh hOJQJh"hB* OJPJQJ^Jhph(h hB* OJPJQJ^JhphBBBBBBBCCCCCCCDDD D]H_HIIϽϱjPjCjhEh0JCJaJ2j6hB* CJOJQJU^JaJph,jhB* CJOJQJU^JaJph#hB* CJOJQJ^JaJph)hbhB* CJOJQJ^JaJphhOJQJhh hOJQJh#h h>*B*OJQJhph,jh h>*B*OJQJUhph2j5h h>*B*OJQJUhphIJJJ?K@KAKKKLLLLLvLwLLLLLLLll[MAh hOJQJhhB* CJOJQJph!hEhB* CJOJQJph$h1gh0JCJOJQJ^JaJ)h1ghB* CJOJQJ^JaJph2jh1ghB* CJOJQJU^JaJph#hB* CJOJQJ^JaJph)hbhB* CJOJQJ^JaJph&h6B* CJOJQJ^JaJph,hBh6B* CJOJQJ^JaJphLLMMMMMMMMMPPRRTTT]T^T颙rr]rF2Fr&h6B* CJOJQJ^JaJph,hVh6B* CJOJQJ^JaJph)hEhB* CJOJQJ^JaJph#hB* CJOJQJ^JaJph)hbhB* CJOJQJ^JaJphhOJQJhh hOJQJh#h h>*B*OJQJhph2jd7h h>*B*OJQJUhphh>*B*OJQJhph,jh h>*B*OJQJUhphRRTT^T0U4UUUUVV%V4VUVnVVVVVVW*W>WYWW $7$8$H$Ifgd;h{gdgd^T_TTT.U/U0U4U5UUUUUUUVVV%V(V4V6VUVlVnVpVVVVVVVVVVWWW*W,W>W@WYW[WWѬѬ|||||||||||||||-hlfhB* CJOJPJQJ^JaJph0hlfh5B* CJOJPJQJ^JaJph#hB* CJOJQJ^JaJph$hEh0JCJOJQJ^JaJ)hEhB* CJOJQJ^JaJph2jhEhB* CJOJQJU^JaJph,WWWWWZZ1[[[qhha\\\\hgdxgdxgdkd7$$IflF $x x x t06    44 layt;h{ WWWWWWWWWWWWWWZZ0[1[ܿmdO=O=#hB* CJOJQJ^JaJph)hZghB* CJOJQJ^JaJphhOJQJh#h h>*B*OJQJhph2jP8h h>*B*OJQJUhphh>*B*OJQJhph,jh h>*B*OJQJUhphh hOJQJh!hX8hB* CJOJQJphhB* CJOJQJph)hlfhB* CJOJQJ^JaJph1[2[>[p[r[s[[[[[[[[[[[[[[[קsdJs8s#h h>*B*OJQJhph2j8h h>*B*OJQJUhphh>*B*OJQJhph,jh h>*B*OJQJUhphh hOJQJh!hX8hB* CJOJQJphhB* CJOJQJphhC=h0JCJaJ)hZghB* CJOJQJ^JaJph#hB* CJOJQJ^JaJph,jhB* CJOJQJU^JaJph[[\\\]]$^^^_ a:a^aab.bcpdqd 1$]gdx1$]gd 7$8$H$gdxgdxgdgd9xgd9gdxgd9[[\\\\\\\\\\\\\]]Ͼj\S>,#h9B* CJOJQJ^JaJph)h9h9B* CJOJQJ^JaJphh9OJQJhh9h90JOJQJh,j<9h9>*B*OJQJUhphh9>*B*OJQJhph&jh9>*B*OJQJUhphh h9OJQJhh9B* CJOJQJph!h9h9B* CJOJQJph#hB* CJOJQJ^JaJph)hqchB* CJOJQJ^JaJphhOJQJh]]]]]^^^!^"^#^$^^^^^^^ԃnYK:K.h hOJQJh!hX8hB* CJOJQJphhB* CJOJQJph)hqch9B* CJOJQJ^JaJph)h9h9B* CJOJQJ^JaJphh9OJQJhh9h90JOJQJh,j9h9>*B*OJQJUhphh9>*B*OJQJhph&jh9>*B*OJQJUhphh h9OJQJhh9B* CJOJQJph!h9h9B* CJOJQJph^^^^^_____a a9a:a;a*B*OJQJUhphhB* CJOJQJhph `!h?q hB* CJOJQJph-h5hB* CJOJPJQJ^JaJph-hQRhB* CJOJPJQJ^JaJphhOJQJhh hOJQJh#h h>*B*OJQJhph2j,:h h>*B*OJQJUhphh>*B*OJQJhph,jh h>*B*OJQJUhphUa[a\a]a^aaabbb#b$b%b+b,b-b.bccy_H-h hB* CJOJPJQJ^JaJph2j;h h>*B*OJQJUhphh>*B*OJQJhphhB* CJOJQJph'hB* CJOJPJQJ^JaJph-h?q hB* CJOJPJQJ^JaJphhOJQJhh hOJQJh,jh h>*B*OJQJUhph#h h>*B*OJQJhphcc*B*OJQJhph2j;h h>*B*OJQJUhphh>*B*OJQJhph,jh h>*B*OJQJUhphh hOJQJhhB* CJOJQJph'hB* CJOJPJQJ^JaJph(h1gh0JCJOJPJQJ^JaJ-h1ghB* CJOJPJQJ^JaJph6jh1ghB* CJOJPJQJU^JaJphqdddef6fffffhhhh]^=^gdgdxgdx1$]gdxgdx1$]gddeefff+f,f-f3f4f5f6fffffh÷we\H.H3hh56B* CJOJPJQJ^JaJph'hB* CJOJPJQJ^JaJphhOJQJh#h h>*B*OJQJhph2j<h h>*B*OJQJUhphh>*B*OJQJhph,jh h>*B*OJQJUhphh hOJQJhhB* CJOJQJph-h?q hB* CJOJPJQJ^JaJph-hhB* CJOJPJQJ^JaJphhhhi]^234:;<Ѻ륔qbHq6q#h h>*B*OJQJhph2ju<h h>*B*OJQJUhphh>*B*OJQJhph,jh h>*B*OJQJUhphh hOJQJh!h5B*CJ\^JaJph3e$h hB* CJOJQJhphU-hhB* CJOJPJQJ^JaJph3hh56B* CJOJPJQJ^JaJph'hB* CJOJPJQJ^JaJphNIH funding or state why such sharing is restricted or not possible. Unlike the NIH Data Sharing Policy, the submission of a model organism sharing plan is NOT subject to a cost threshold of $500,000 or more in direct costs in any one year, and is expected to be included in all applications where the development of model organisms is anticipated. 3) Genome Wide Association Studies (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-08-013.html). Applications and proposals that include GWAS, regardless of the requested costs, are expected to include as part of the Research Plan either a plan for submission of GWAS data to the NIH designated data repository or an appropriate explanation for why submission to the repository will not be possible. Additional Comments to Applicant (HYPERLINK \l "ADDCOM1"return) Reviewers may provide guidance to the applicant or recommend against resubmission without fundamental revision.`     < <>  Page\*arabic  <=Ừjh[pUh[pj *h[p<U*h@[jh@[U hQhs;CJOJQJ^JaJ&hB* CJOJQJ^JaJhph#h~GBB* CJOJQJ^JaJph)hLhB* CJOJQJ^JaJphhOJQJh ^ gd;h{gds; 1$]gd501h:ps;/ =!"#$% 8 0 01h:ps;/ =!"#$% 5 01h:pl@/ =!"#$% 8 0 01h:ps;/ =!"#$% ; 0 001h:ps;/ =!"#$% 5 01h:pl@/ =!"#$% 8 001h:pl@/ =!"#$% 5 01h:pl@/ =!"#$% 8 001h:pl@/ =!"#$% 8 0 01h:ps;/ =!"#$% 8 001h:p[p/ =!"#$% 5 01h:p[p/ =!"#$% 8 001h:p[p/ =!"#$% 5 01h:p[p/ =!"#$% 8 001h:p[p/ =!"#$% 5 01h:p[p/ =!"#$% 8 001h:p[p/ =!"#$% 5 01h:p[p/ =!"#$% 8 001h:p[p/ =!"#$% 5 01h:p[p/ =!"#$% ; 0 001h:pq / =!"#$% 8 0 01h:pq / =!"#$% ; 0 001h:pq / =!"#$% 8 0 01h:pq / =!"#$% ; 0 001h:pq / =!"#$% 8 0 01h:pq / =!"#$% ; 0 001h:pq / =!"#$% < 0 0&P1h:pq / =!"#$% ; 0 001h:pq / =!"#$% 8 0 01h:pq / =!"#$% ; 0 001h:p;h{/ =!"#$% 8 0 01h:p;h{/ =!"#$% ; 0 001h:p;h{/ =!"#$% B 00P1h:p;h{/ =!"#$% DpE 000P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% DpB 00P1h:p;h{/ =!"#$% Dp? 0P1h:p;h{/ =!"#$% Dp8 001h:pE^/ =!"#$% wDyK  GUIDELINES{DyK  INSTRUCTIONSsDyK  OVERALL2$$If!vh#v%:V l t 0%5%/ yt;d$$If!vh#v%:V l4 t 0%5%/ f4yt;d}DyK SIGNIFICANCE2$$If!vh#v%:V l4 t 05%/ f4ytE^$$If!vh#v%:V l t 05%/ ytE^}DyK INVESTIGATOR2$$If!vh#v%:V l4 t 05%/ f4ytE^$$If!vh#v%:V l t 05%/ ytE^yDyK  INNOVATION2$$If!vh#v%:V l4 t 05%/ f4ytE^$$If!vh#v%:V l t 05%/ ytE^uDyK  APPROACH2$$If!vh#v%:V l t 05%/ ytE^$$If!vh#v%:V l4 t 05%/ f4ytE^{DyK  ENVIRONMENT2$$If!vh#v%:V l t 05%/ ytE^$$If!vh#v%:V l4 t 05%/ f4ytE^$$If!vh#v%:V l t 05%/ ytg|$$If!vh#v%:V l4 t 05%/ f4ytg|qDyK HUMANS2DfClick Here to Select,Acceptable Risks and/or Adequate Protections0Unacceptable Risks and/or Inadequate Protections"Not Applicable (No Human Subjects)DProtectHS_Comments6DfClinTrials_DropDownClick Here to Select Acceptable Unacceptable#Not Applicable (No Clinical Trials)DClinTrials_Comments$$If!vh#v%:V l4 t 0%5%/ f4ytl@wDyK  INCLUSION2DfInclusionGenDropdown Click Here to Select Gender CodeG1A - Both Genders, Acceptable G1U - Both Genders, UnacceptableG2A - Only Women, AcceptableG2U - Only Women, UnacceptableG3A - Only Men, AcceptableG3U - Only Men, Unacceptable G4A - Gender Unknown, Acceptable"G4U - Gender Unknown, UnacceptableDfInclusionMinDropdown "Click Here to Select Minority Code)M1A - Minority & Non-minority, Acceptable+M1U - Minority & Non-minority, UnacceptableM2A - Only Minority, Acceptable!M2U - Only Minority, Unacceptable#M3A - Only Non-minority, Acceptable%M3U - Only Non-minority, Unacceptable1M4A - Minority Representation Unknown, Acceptable'M5A - Only Foreign Subjects, Acceptable)M5U - Only Foreign Subjects, Unacceptable`DfInclusionChiDropdown "Click Here to Select Children Code#C1A - Children & Adults, Acceptable%C1U - Children & Adults, UnacceptableC2A - Only Children, Acceptable!C2U - Only Children, Unacceptable&C3A - No Children Included, Acceptable(C3U - No Children Included, Unacceptable2C4A - Children Representation Unknown, Acceptable2C4U - Children Representation Unknown,UnacceptabletDText1$$If!vh#v%:V l t 0%5%/ ytl@sDyK  ANIMALS2>DfAnimal_Subj_DropDownClick Here to Select Acceptable Unacceptable&Not Applicable (No Vertebrate Animals)tDText1$$If!vh#v%:V l4 t 0%5%/ af4ytl@yDyK  BIOHAZARDS2,DfBiohazards_DropDownClick Here to Select Acceptable UnacceptableNot Applicable (No Biohazards)tDText1$$If!vh#v%:V l t 0%5%/ ytl@}DyK RESUBMISSION2$$If!vh#v%:V l4 t 0%5%/ f4ytl@sDyK  RENEWAL2$$If!vh#v%:V l4 t 0%5%/ f4ytl@uDyK  REVISION2$$If!vh#v%:V l4 t 0%5%/ f4yt}qDyK BUDGET2HDfBudget_DropDownClick Here to SelectRecommend as Requested1Budget Modifications Recommended (in amount/time)DBudget_Commentsx$$If!vh#v%:V l t 065%yt[p}DyK SELECTAGENTS24DfSelectAgent_DropDownClick Here to Select Acceptable Unacceptable!Not Applicable (No Select Agents)DSelectAgent_Comments|$$If!vh#v%:V lm t 065%yt[psDyK  FOREIGN28DfForeign_DropDownClick Here to Select Justified Unjustified)Not Applicable (No Foreign Organizations)DForeign_Commentsx$$If!vh#v%:V l t 065%yt[p$$If!vh#v%:V l t 0%5%/ yt\_$$If!vh#v%:V l4 t 0%5%/ f4yt\_sDyK  SHARING2>DfRsrcSharing_DropDownClick Here to Select Acceptable Unacceptable&Not Applicable (No Relevant Resources)DRsrcSharing_Commentsx$$If!vh#v%:V l t 065%yt[pqDyK ADDCOM2x$$If!vh#vh%:V l t 065%yt[px$$If!vh#vh%:V l t 065%yt[pmDyK BEGINmDyK BEGINmDyK BEGINmDyK BEGINsDyK  OVERALL1}DyK SIGNIFICANCE1}DyK INVESTIGATOR1yDyK  INNOVATION1uDyK  APPROACH1{DyK  ENVIRONMENT1qDyK HUMANS1QDyK yK http://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Protection_and_Inclusion_a5.pdfyX;H,]ą'cwDyK  INCLUSION1s$$If!vh#vx :V l t065x yt;h{sDyK  ANIMALS1yDyK  BIOHAZARDS1}DyK RESUBMISSION1sDyK  RENEWAL1uDyK  REVISION1qDyK BUDGET1}DyK SELECTAGENTS1sDyK  FOREIGN1sDyK  SHARING1qDyK ADDCOM1 v02 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@666_HmH nH sH tH D`D 1gNormalOJQJ_HaJmH sH tH \@\ s Heading 1$$@&a$!5;CJKH OJQJ\^JaJDA D Default Paragraph FontRi@R  Table Normal4 l4a (k (No List BU`B E^ Hyperlink>*CJOJQJo(phV/V sHeading 1 Char!5;CJKH OJQJ\^JaJH^@H E^ Normal (Web)^_H aJVo!V E^ Title Char*5CJ KHOJQJ\_HaJ mH sH tH R>R E^Title$<@&a$5CJ KHOJQJ\aJ RoAR E^ Subtitle Char CJOJQJ_HaJmH sH tH FJF E^Subtitle$<@&a$ CJOJQJ4 @b4 s;0Footer  H$:/q: s;0 Footer Char OJQJaJ@@@ s;List Paragraph ^fof s;Default 7$8$H$1B*CJOJPJQJ^J_HaJmH phsH tH FV F FollowedHyperlink >*B*phPK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭VGRU1a$N% ʣꂣKЛjVkUDRKQj/dR*SxMPsʧJ5$4vq^WCʽ D{>̳`3REB=꽻Ut Qy@֐\.X7<:+& 0h @>nƭBVqu ѡ{5kP?O&Cנ Aw0kPo۵(h[5($=CVs]mY2zw`nKDC]j%KXK 'P@$I=Y%C%gx'$!V(ekڤք'Qt!x7xbJ7 o߼W_y|nʒ;Fido/_1z/L?>o_;9:33`=—S,FĔ觑@)R8elmEv|!ո/,Ә%qh|'1:`ij.̳u'k CZ^WcK0'E8S߱sˮdΙ`K}A"NșM1I/AeހQתGF@A~eh-QR9C 5 ~d"9 0exp<^!͸~J7䒜t L䈝c\)Ic8E&]Sf~@Aw?'r3Ȱ&2@7k}̬naWJ}N1XGVh`L%Z`=`VKb*X=z%"sI<&n| .qc:?7/N<Z*`]u-]e|aѸ¾|mH{m3CԚ .ÕnAr)[;-ݑ$$`:Ʊ>NVl%kv:Ns _OuCX=mO4m's߸d|0n;pt2e}:zOrgI( 'B='8\L`"Ǚ 4F+8JI$rՑVLvVxNN";fVYx-,JfV<+k>hP!aLfh:HHX WQXt,:JU{,Z BpB)sֻڙӇiE4(=U\.O. +x"aMB[F7x"ytѫиK-zz>F>75eo5C9Z%c7ܼ%6M2ˊ 9B" N "1(IzZ~>Yr]H+9pd\4n(Kg\V$=]B,lוDA=eX)Ly5ot e㈮bW3gp : j$/g*QjZTa!e9#i5*j5ö fE`514g{7vnO(^ ,j~V9;kvv"adV݊oTAn7jah+y^@ARhW.GMuO "/e5[s󿬅`Z'WfPt~f}kA'0z|>ܙ|Uw{@՘tAm'`4T֠2j ۣhvWwA9 ZNU+Awvhv36V`^PK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 0_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!g theme/theme/theme1.xmlPK-! ѐ' theme/theme/_rels/themeManager.xml.relsPK] )cO> K  k   ^ o:'(C)h):+d+,%-//W/I1o14/4556 7@>??@^GHJJ1NNNNOOP$QQR:T^TU.UVqWWWY6Y__m``" "7 "q " " "!"V!"!"!""";""u""""""#"W#"#"#"#"9$"p$"$"$"$%"^%"%"%"&"P&"&"&"'">'"{'"'"("J("("(")"T)")")"*"^*"*"*"'+"h+"+"+"1,"r,",",";-"|-"-"."E."."." /"O/"/"/"0"Y0"0"0"1"c1"1"1")2"m2"2"2"33"w3"3 $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$' ;  8 B\Mr$ i7*+-L15E6Y8:N<@BIL^TW1[[]^Uacdh<57:;>AEILMOQRSUVY\]_abfgklnoprsuvwxz{|} ^ w C \  7 q @uSXZ`/5@>RW[qd689<=?@BCDFGHJKNPTWXZ[^`cdehijmqty~Y[y&B\ +8|a~)Bacs 9EKPl )<>Nv  ' 4 U q y K d   - U a g l p  * K op #6')(((((D)^)e);+Z+a+,-"-0/M/T/J1e1l14%4,4555667@>>??v???@@^GG.H4HHHJJJ1NrNNNNNOOOPQ!QQQR;TTT[TU$U+UV>) * , - . . / Q u v v K j l o w y         U / 0 1 2 < = A A Y \ \ ^ -;j(((((4)b)b)b)b)b)b)b)c)c)c)c)c)c)c)c)d)d)-+-+]+]+]+]+]+]+]+]+]+]+^+^+^+^+^+^+^+^+^+^+^+^+^+^+^+^+^+^+^+^+^+^+^+_+_+_+_+_+_+_+_+_+_+_+_+_+_+_+_+`+`+,------!-#/#/P/P/P/P/Q/Q/Q/Q/Q/Q/Q/Q/Q/Q/Q/Q/R/R/R/R/R/R/S/@1i1j1j1j13)4)4*4*4555555577>>>>>????@@@@@@@@GHHJJJJJJJNNNNNNNNNNNNNOOOOOOOOOOOOOPQQQQQQQRRRRRRRRRR T T T TWTWTXTXTXTXTXTXTXTXTXTXTXTXTXTYTYTYTYTYTYTYTYTYTZTT(U(U(U(U(UKWqWWWWWWWWXX/Y/Y/Y/Y0Y0Y0Y0Y0Y0Y0Y0Y0Y0Y0Y0Y1Y1Y1Y1Y1Y2Y____________`@@@@@@@ @ @ @ @ @@@@@@@@@@@@@ @!@"@#@$@%@&@'()*+@,@-@.@/@0@1@2@34567@8@9@:@;@<=>@?@@@A@B@C@D@EFG@H@I@J@K@L@M@NO@P@Q@RS@T@U@V@WXY@Z@[@\@]@^_@`@a@b@c@d@fegh@i@j@k@l@m@n@poqr@s@t@u@v@w@x@y@{z|}@~@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@ @ @ @ @ @@@@@@@@@@@@@@@@@ @!@"@#@$@%@&@'@(@)@*+@,@-@.@/@0@1@2@34@5@6@7@8@9@:@;@<@=@>?@@@A@B@C@D@E@F@G@H@I@J@KL@M@N@O@P@Q@RS@T@U@V@W@X@Y@Z@[@\@]^_`a@b@c@d@e@f@g@h@i@j@k@l@m@n@o@p@q@r@s@t@u@v@w@x@y@z{@|@}@~@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@'1UU&IKMOSS_ 1226|aLSSTVYc Ltvx{02378>O* + - . / / 0 Q v w w K k m p x z        . h  0 1 2 3 = > B B Y \ \ ^ .;k(((((4)c)c)c)c)c)c)c)d)d)d)d)d)d)d)d)e)e)-+-+^+^+^+^+^+^+^+^+^+^+_+_+_+_+_+_+_+_+_+_+_+_+_+_+_+_+_+_+_+_+_+_+_+`+`+`+`+`+`+`+`+`+`+`+`+`+`+`+`+a+a+,- - - - - -"-#/#/Q/Q/Q/Q/R/R/R/R/R/R/R/R/R/R/R/R/S/S/S/S/S/S/T/@1j1k1k1k13*4*4+4+4555555577>>>>>????@@@@@@@@GHHJJJJJJJNNNNNNNNNNNNNOOOOOOOOOOOOOPQQQQ Q QQRRRRRRRRRR T T T TXTXTYTYTYTYTYTYTYTYTYTYTYTYTYTZTZTZTZTZTZTZTZTZT[TT)U)U)U)U)ULWqWWWWWWWWXX0Y0Y0Y0Y1Y1Y1Y1Y1Y1Y1Y1Y1Y1Y1Y1Y2Y2Y2Y2Y2Y3Y____________`CCXXX`CCXXX`9*urn:schemas-microsoft-com:office:smarttagsplaceB*urn:schemas-microsoft-com:office:smarttagscountry-region X2(n`p`q`s`t`v`w`y`z```##7788<&<vB~BTT'X9Xa`k`n`p`q`s`t`v`w`y`z```,_D9)ctu 9P>PU z   / U l  o p  s M$a$4IUIOOP"Q`_9ctu 6 7 ? @ T U z } J e k l   o l m u v ~ @AHK !c#d#g#h#####OOOOP"Q#Q$Qk`m`n```` ?xnic?8TjKXRh^`OJQJo(hHh^`OJ QJ ^J o(hHohp^p`OJ QJ o(hHh@ ^@ `OJQJo(hHh^`OJ QJ ^J o(hHoh^`OJ QJ o(hHh^`OJQJo(hHh^`OJ QJ ^J o(hHohP^P`OJ QJ o(hH^`OJQJo(hH^`OJ QJ ^J o(hHo pp^p`hH. @ @ ^@ `hH. ^`hH. ^`hH. ^`hH. ^`hH. PP^P`hH.^`OJQJo(hH^`OJ QJ ^J o(hHop^p`OJ QJ o(hH@ ^@ `OJQJo(hH^`OJ QJ ^J o(hHo^`OJ QJ o(hH^`OJQJo(hH^`OJ QJ ^J o(hHoP^P`OJ QJ o(hHic? jK ?ic?/b10U."                 ."        ;#^]rj" #s>:Kg|w!D&H.,a;s;i=Y?A~GBlCME&F]FOK"DNR@#VHVuW@[l[H\E^5`E`#bYc;dSdC.fg1g(Rg|yo[p|Xsteu{F/{;h{L~)Sv:H a}Q1l@/h9 "+#^B>5s9dM?=E\_ST2=#q yrSn`p`@p \`@$@4@0@Unknown G*Ax Times New Roman5Symbol3. *Cx ArialI. ??Arial Unicode MS7@CambriaA$BCambria Math?. Arial Black7. [ @Verdana7.@CalibriC.,{ @Calibri Light?= *Cx Courier New;Wingdings"hZGZGd R 1d R 1d24=`=`3qHX ?E^*!xx &P01 Research Project Critique Templateebuczko1Li, Xiang-Ning (NIH/CSR) [E]   Oh+'0 (4 T ` lx(P01 Research Project Critique Template ebuczko1 Normal.dotm Li, Xiang-Ning (NIH/CSR) [E]2Microsoft Office Word@@*;T<@*;T< d R՜.+,D՜.+,\ hp   NIH/NIAID1=` 'P01 Research Project Critique Template Title   , 8Dl x  _PID_HLINKS7display_urn:schemas-microsoft-com:office:office#Editor xd_SignatureOrder TemplateUrl xd_ProgIDPublishingStartDate PublishingExpirationDate _SourceUrl _SharedFileIndex !S0000000000000000000000000000001 !P0000000000000000000000000000001 display_urnA>jjADDCOM1E SHARING1\ FOREIGN1yK2http://grants.nih.gov/grants/policy/select_agent/ SELECTAGENTS1cfBUDGET1  REVISION1P RENEWAL1 RESUBMISSION1iz BIOHAZARDS1l93http://grants.nih.gov/grants/olaw/VASchecklist.pdf^ ANIMALS1%Rhttp://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Worksheet.pdfRoahttp://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Protection_and_Inclusion.pdfx/ INCLUSION1%Rhttp://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Worksheet.pdfRoahttp://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Protection_and_Inclusion.pdfRdhttp://grants.nih.gov/grants/peer/guidelines_general/Human_Subjects_Protection_and_Inclusion_a5.pdfkgHUMANS1Z ENVIRONMENT1  APPROACH1jg INNOVATION1 INVESTIGATOR1 SIGNIFICANCE1Y OVERALL1 BEGINI0Yhttp://grants.nih.gov/grants/peer/guidelines_general/scoring_system_and_procedure_a5.pdf |BEGIN yBEGINesv;http://grants.nih.gov/grants/guide/pa-files/PA-07-030.html1$sGhttp://www.nigms.nih.gov/Research/Application/ProgProjFundPolicies.htm(%p(http://www.nigms.nih.gov/About/overview mBEGINjjjADDCOM2Fb SHARING2_Z FOREIGN2 RSELECTAGENTS2cfJBUDGET2 G REVISION2SD RENEWAL2 ARESUBMISSION2iz9 BIOHAZARDS2]1 ANIMALS2x,% INCLUSION2kgHUMANS2Y ENVIRONMENT2  APPROACH2jg INNOVATION2  INVESTIGATOR2  SIGNIFICANCE2Z OVERALL2  INSTRUCTIONSg` GUIDELINESSystem Account2800.00000000000, System Account  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~     30 !"#$%&'()*+,-./12Root Entry Fy> Data <1TableWordDocument3SummaryInformation(DocumentSummaryInformation8MsoDataStore y>y>VYHLYSNLTDYA==2y>y>Item  %PropertiesLNEWCJJP==2 y>y>Item  PropertiesOSUC4JPV0==2y>y>Item PropertiesS & w>DocumentLibraryFormDocumentLibraryFormDocumentLibraryFormschemaRef ds:uri="http://schemas.micr emID="{D1B094F7-B140-4E7A-A227-F88F83955A86}" xml This value indicates the number of saves or revisions. The application is responsible for updating this value after each revision. ffice/2006/documentManagement/types"/>   F Microsoft Word 97-2003 Document MSWordDocWord.Document.89qCompObj%r