ࡱ>  bjbj 4 || $F('''''''>)+''( ''%'ak ]&'(0F(q&p,p,('p,'T'' F(p,| : Outline for Journal Club Presentation I. Introduction A. Study objective/purpose 1. Is the purpose of the study clearly stated? Hypotheses Is the research question or hypothesis clearly stated? II. Methodology/Study Design Design of the experiment/trial 1. Is it a clinical trial, cohort, case-control, cross-sectional, or case-series? B. Population/sample 1. What are the criteria for inclusion and exclusion of subjects? 2. What limitations result? C. Treatment allocation 1. How are subjects chosen or recruited? Randomly? 2. If not: a. Are they representative of the population? b. How were patients selected for the study to avoid bias? c. If historical controls were used, were methods and criteria the same for the experimental group, and were cases and controls compared on prognostic factors? If there is a control group, how is it chosen? How are patients followed up? Who are the dropouts, and how many are there? Were the circumstances for patients dropping out explained by the authors? Do the authors explain or give a reference to any unusual method used in the study? D. Outcome measures 1. Are there multiple endpoints? 2. Are subgroup analyses performed and, if so, reported appropriately? Statistical analysis Are the statistical methods used in the study specified in sufficient detail? Is there a statement about the sample size or power? (Statements on power are especially critical in a negative study). Do the statistical tests answer the research questions? Are all relevant outcomes reported? Were repeated measures made over time, and if so, were they analyzed appropriately? III. Results Do the results relate to research questions proposed in the study objectives? Are actual values reported (e.g., means, standard deviations, proportions), not just the results of statistical tests? In paired designs, is the magnitude and range of the differences reported? Are group similar on baseline measures? If not, were appropriated analyses done to take differences into consideration? Are appropriate graphics used to present results clearly? IV. Study Discussion/Students Conclusions Interpretation of results Are the questions posed in the study adequately addressed? Are the conclusions justified from the data? Does the student reflect on the clinical and statistical significance of results from the study? Does the student compare results from the study to those of similar studies performed? Discuss study limitations Are shortcomings of the study addressed and constructive suggestions given for the future research? Applicability of results 1. 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'2,23!22',2!3,'220,,,!0',,2.TT $ /@@ ~LP - TT/@@LP -Rp@"Arial-\- -@-N] -- (- -N] -- q^- - | zr^X3.*Cx Arial- ^-x0^(-(-pz^P-| dv% % %  % % % TX u{/@@dLPB.B% % % TTv Ey/@@vdLP % % % TF {/@@Fd L`HypothesesI0222,(,(TT E{/@@dLP -!"  % % % TXF}/@@FLP1.2% % % TT}q/@@LP c% % % Tr}/@@r6LIs the research question or hypothesis clearly stated? '2,!,'-,!,223,'222!30222,'',,,!0',-1-TT}/@@LP y-!"  TTa/@@JLP - % % % T`cT/@@LTII.''TTUc/@@ULP Tc/@@L|Methodology/Study Design^,!82822228!882H,'27TTc/@@LP 6 % % % TXzG/@@0LPA.H% % % TT{EE/@@{0LP l% % % TF G/@@F0LDesign of the experiment/trH,'123!2,,32,!N,2!T`  G/@@ 0LTialt,TT % G/@@ 0LP -!"  TXFI/@@FLP1.2TTIq/@@LP $T$rIW /@@r$LIs it a clinical trial, cohort, case ',,2,,!,,222",,',TTX Iy /@@X LP-"Tz I /@@z Lhcontrol, cross,22!2,!2''TT I /@@ LP-!T Ic/@@ Lpsectional, or case(,,22,2!,,'-TTdI/@@dLP-" Txr-/@@rL\series?',!,'-TT-/@@LP - TTF/r/@@FLP - TT /@@LP ,TXu /@@LPB.BTTvE /@@vL&" WMFC 7wP TF- /@@FLpPopulation/sampley8222,22',N2+TT.Z /@@.LP o- TT  /@@o LP ,TT E /@@o LP ,TXF  /@@Fo LP1.2TT q /@@o LP Tr  /@@ro >LWhat are the criteria for inclusion and exclusion of subjects?_2,,!,2,-!,!,!3!2,2'22,22,3,2'222!'22,,'-TT  /@@o LP a- TT  /@@ LP a,TT E /@@ LP ,TXF  /@@F LP2.2TT q /@@ LP Tr 2 /@@r L|What limitations result?_2,N,22'!,'2-TT3 _ /@@3 LP - TT l /@@U LP - TTn  /@@ LP ,TXn u /@@ LPC.CTTvn E /@@v LP TFn  /@@F LtTreatment allocation=!,,N,2,2-,22TTn  /@@ LP - TT R /@@; LP ,TT ER /@@; LP ,TXF R /@@F; LP1.2TT qR /@@; LP Tr f R /@@r; LpHow are subjects cH2H,",'22,,',Tg dR /@@g ; Lhosen or recruited? 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LP - TT:  /@@ LP $,TT: E /@@ LP ",TTF: q /@@F LP d,TXr:  /@@r LPb.2TT:  /@@ LP T: < /@@ 7LHow were patients selected for the study to avoid bias?H2HH,",2,,2'',-,,2!2!2,'2402,2222,&-TT=: i /@@= LP e- TT  /@@ LP ,TT E /@@ LP ,TTF q /@@F LP ,TXr  /@@r LPc.,TT  /@@ LP T  /@@ <LIf historical controls were used, were methods and criteria "2'2!,,,22!2'I,",2',2H-!,N,222',32,!,!,TT  /@@ LP - TT  /@@z LP ,TT E /@@z LP @,TTF q /@@Fz LP ,TTr  /@@rz LP ,T Z /@@z Lthe same for the experimental 2,',N,!2!2,,32,!N,2,T[  /@@[ z Lgroup, and were cases and 2!222,22I,!,,,(,',22TT  /@@z LP I- TT /@@ LP ,TT E/@@ LP ,TTF q/@@F LP ,TTr /@@r LP r,T| /@@ L\controls,22!2'TT /@@ LP eT /@@ Lcompared&" WMFC w on prognostic factors?,2N2,!,2223"2122',",,2!'-TT A/@@ LP - % % % TXFw/@@F`LP3.2% % % TTu/@@`LP K% % % Tprw/@@`LX T`sR w/@@s`.LIf there is a control group, how is it chosen? !2,!,',,22!21"22222H',22',2-TTS  w/@@S `LP -!"  % % % TXFy/@@FLP4.2% % % TTy/@@LP K% % % Tpyq/@@LX Tryn/@@r=LHow are patients followed up? 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TpEq/@@LX TrE@ /@@rLpused in the study?2',222,'23/.TTA Em /@@A LP - TT)/@@LP - TT+/@@LP ,TX+z/@@LPD.HTT{+E/@@{LP TF+A/@@FLlOutcome measuresH2,2N,N,,'2",(TTB+n/@@BLP - TT/@@LP ,TTE/@@LP ,TXF/@@FLP1.2TTq/@@LP Tr /@@rLAre there multiple endpoints?H!,2,",N22,,22232&-TT F /@@ LP - TT/@@kLP ,TTE/@@kLP ,TXF/@@FkLP2.2TTq/@@kLP Tr/@@rk5LAre subgroup analyses performed and, if so, reported H!,'231!222,2,0','3,!!2!N,2,22!'2",22",2TT /@@kLP - Tr/@@r Lhappropriately,22!22!,,/TT/@@LP?/TT/@@LP - TTh/@@QLP - % % % TXjo/@@LPE.=% % % TTpjE/@@pLP % % % TFj+/@@FLtStatistical analysis8,',,,2,0'(TT,jX/@@,LP -!"  % % % TXFN/@@F7LP1.2% % % TTqL/@@7LP % % % Tr, N/@@r7LtAre the statisticalH!,2,',',,TT- E N/@@- 7LP TxF N/@@F &WMFCw72Lmethods used in the study specified in sufficient N,232'2',222,'230'2-,!,22'2!!,,2TTN/@@7LP -!"  TxrP|/@@rL\detail?2,,-TT}P/@@}LP - % % % TXF4/@@FLP2.2% % % TTq2/@@LP % % % Tr4/@@r@LIs there a statement about the sample size or power? (Statements '2-!,,',,N,2,2222,',N2,'-,2!22H,"-!8,,N,2'TT4/@@LP -!"  Tr6/@@r6Lon power are especially critical in a negative study).2222H,!-!,,'3,,,0-!,,2,2-1,2,'241!TT6/@@LP - % % % TXF/@@FLP3.2% % % TTq/@@LP % % % Trv /@@r"LDo the statistical tests answer thH22,',',,,'',2'H,!2Tw &/@@w Le research questions? Are all ,",',-!,222,'32&.H!,,TT'S/@@'LP -!"  Tr /@@rvLrelevant outcomes reported?!,,2,222,2N,'!,22!,2-TT  /@@ vLP - % % % TXF/@@FLP4.2% % % TTq/@@LP % % % Tr%/@@r<LWere repeated measures made over time, and if so, were they _,!,!,3,,,2N-,'2!,'N,2,22,!N,,22!'2H,!,2.0TT&R/@@&LP -!"  Tr/ s/@@r\L|analyzed appropriately?,2,/-,2,22!22!,,//TT0 \ s/@@0 \LP -% % 666666666666666666666666666666666666 6 66 6  6 66 6  6 66 6  6 66 6  6 66 6 66666666666666666666  d.@Times New Roman--- C2 S%cOutline for Journal Club Presentation  2 Sc @Times New Roman--- 2 `2c ---2 nZcI. 2 nbc 2 n~ cIntroduction 2 nc --- 2 |Zc $2 |~cA. 2 |c .2 |cStudy objective/purpose 2 |c  2 Zc $ 2 ~c $2 c1. 2 c L2 +cIs the purpose of the study clearly stated? 2 c  2 Zc @"Arial------2 ~cB.--- 2 c ---2 cHypotheses  2 c ,c'---2 c1.--- 2 c ---\2 6cIs the research question or hypothesis clearly stated? 2 c ,c' 2 Zc ---2 ZcII.a 2 fc /2 ~cMethodology/Study Design   2 c ---2 ~cA.--- 2 c ---42 cDesign of the experiment/tr 2 &ciala 2 2c ,c'2 c1. 2 c A2 $cIs it a clinical trial, cohort, case 2 \c- 2 `ccontrol, cross 2 c-&2 csectional, or case 2 c-2 cseries?s 2 c  2 c  2 Zc $2 ~cB. 2 c %2 cPopulation/sample  2 c  2 !Zc $ 2 !~c $2 !c1. 2 !c h2 !>cWhat are the criteria for inclusion and exclusion of subjects?  2 !c  2 .Zc $ 2 .~c $2 .c2. 2 .c /2 .cWhat limitations result?   2 .9c  2 <Zc  2 JZc $2 J~cC. 2 Jc )2 JcTreatment allocation  2 Jc  2 XZc $ 2 X~c $2 Xc1. 2 Xc &2 XcHow are subjects c 82 X chosen or recruited? Randomly?  2 Xc  2 eZc $ 2 e~c $2 ec2. 2 ec 2 ecIf not:s 2 ec  2 sZc $ 2 s~c $ 2 sc $2 sca. 2 sc J2 s*cAre they representative of the population? 2 sc  2 Zc $ 2 ~c $ 2 c $2 cb. 2 c ^2 7cHow were patients selected for the study to avoid bias?   2 c  2 Zc $ 2 ~c $ 2 c $2 cc. 2 c e2 <cIf historical controls were used, were methods and criteria    2 c  2 Zc $ 2 ~c $ 2 c $ 2 c $82 cthe same for the experimental   22 {cgroup, and were cases and   2 c  2 Zc $ 2 ~c $ 2 c $ 2 c $2 ccontrols 2 c :2 ccompared on prognostic factors?  2 c ---2 c3.--- 2 c ---2 c P2 .cIf there is a control group, how is it chosen? 2 c ,c'---2 c4.--- 2 c ---2 c g2 =cHow are patients followed up? Who are the dropouts, and how     2 c ,c'j2 ?cmany are there? Were the circumstances for patients dropping ou   2 ct 12 cexplained by the authors? 2 @c ---2 c5.--- 2 c ---2 c m2 AcDo the authors explain or give a reference to any unusual method   2 c ,c'2 c &2 cused in the study? 2 c  2 Zc  2 Zc $2 ~cD. 2 c #2 cOutcome measures   2 c  2 &Zc $ 2 &~c $2 &c1. 2 &c 72 &cAre there multiple endpoints?  2 &Uc  2 4Zc $ 2 4~c $2 4c2. 2 4c [2 45cAre subgroup analyses performed and, if so, reported   2 4c 2 A cappropriately 2 Ac? 2 A c  2 OZc ---2 ]~cE.--- 2 ]c ---)2 ]cStatistical analysis 2 ]c ,c'---2 kc1.--- 2 kc ---(2 kcAre the statistical 2 kc V2 k2cmethods used in the study specified in sufficient  2 kc ,c'2 xcdetail?s 2 xc ---2 c2.--- 2 c ---k2 @cIs there a statement about the sample size or power? (Statements     2 c ,c'\2 6con power are especially critical in a negative study). 2 c ---2 c3.--- 2 c --->2 "cDo the statistical tests answer th:2 `ce research questions? 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