ࡱ> y ,Bbjbj K{{938THd*D.Q*S*S*S*S*S*S*$-/w*w**!!!^Q*!Q*!!:&,E'.v& =**0*&R00E'0E'!w*w* *0 :  TEXTBOOK STUDY GUIDE FOR INTRODUCTION TO HUMAN BIOLOGY for: Human Biology: Concepts and Current Issues, Michael D. Johnson, Pearson Benjamin Cummings, 3rd Edition, 2006. Intro Human Biology (HUB 102) Professor: James C. Marker, Ph.D. NATURE OF SCIENCE Chapter 1 Human Biology, Science, and Society all Pre_Ch_Q's: 1-3 (4, 5); Try_It_Yourself: What 3 criteria does your author recommend be used to evaluate a scientific claim? Cur_Iss: What are two major factors that the FDA tests for when a new drug is being developed? Conpt_Rev:1,2,3,4; Match: all; Fil_Blnk: all; TF: all; Ap_Know: 1;Terms: criteria for defining biological life sources of biological knowledge nature of science scientific method hypothesis role of statisticsexperimental research correlative research descriptive research basic research applied research scientific vs. anecdotal evidence CHEMISTRY OF LIFE Chapter 2 The Chemistry of Living Things all Pre_Ch_Q's: 1-4; Hlth_Watch: What are free radicals? How do antioxidants protect us against free radicals? Dir_in_Sci: Protein folding is a process that is important to a protein having its proper shape. What is the consequence of a protein not being folded into its appropriate shape? Concpt_Rev:1-8; Match: all; Fil_Blnk: all; TF: all; Ap_Know: 1-2; Terms: atom (components) molecule element compound isotope ion electrolyte covalent bonds ionic bonds hydrogen bonds water acid base pH strength of an acid buffer organic inorganic carbohydrate monosaccharide disaccharide polymer polysaccharide glycogencellulose amino acid protein enzyme lipid fat lipoprotein steroid nucleotide DNA RNA ATP THE CELL & CELLULAR REPRODUCTION Chapter 3 - Structure and Function of Cells through section 3.6 (p. 65) Pre_Ch_Q's: (1),2,(3),4 Try_It_Yourself: What process is responsible for our fingers getting wrinkly when they are in water for a while? Dir_in_Sci: Why was the development of tissue/cell cultures important to finding cure for Polio? Concpt_Rev: 4,5,7; Match: 1-5; Fil_Blnk: 9,10; TF: 21-24; Ap_Know: 1 Chapter 17 Cell reproduction and Differentiation pp. 389, 395-397, 400-405; Pre_Ch_Q's: (1), 2, 3 Concpt_Rev: 4,7,9; Match: none; Fil_Blnk: 7,8,10-12; TF: 13-15; Terms: cell theory unicellular multicellular prokaryotic eukaryotic cell size cyto cytoplasm cytoskeletonfluid mosaic model plasma membrane receptor sites intercellular connection nucleus nuclear envelope lysosomes vacuolesmitochondria endoplasmic reticulum Golgi complex filamentous structures selective permeability diffusion - passive, diffusion facilitated active transport endocytosis exocytosisosmosis chromatin chromosome chromotid cell cycle interphase mitosis - phases karyokinesis cytokinesis TISSUES, ORGANS and SYSTEMS & skINTEGUMENTARY SYSTEM Chapter 4 From Cells to Organ Systems including Integumentary System all Pre_Ch_Q's: (1),2-5 Cur_Iss: What characteristics do stem cells have that make them useful to study disease? Hlth_Watch: What specific types of cells are damaged by sunlight? Hlth_Watch: How are skin proteins damaged by sunlight? Concpt_Rev: 2,5-7; Match: 1,4-6; Fil_Blnk: all; TF: all; Ap_Know: 1,2; Terms: epithelial tissue connective tissue muscle tissue nerve tissue interstitial fluid tissue, organ, systemintegument epidermis dermis keratin hair and nailsmelanocytes sebaceous glands sweat glands homeostasis SKELETAL SYSTEM Chapter 5 The Skeletal System all Pre_Ch_Q's: 1 -5 Hlth_Watch: What three treatments are recommended for reducing bone loss associated with having osteoporosis? Hlth_Watch: What is the order (first, last) of heat vs. cold application for treatment of a sprained joint? Concpt_Rev: 1-3,5,8,10; Pre_Ch_Q's: 1-5; Match: 1-5; Fil_Blnk: 7-8; TF: 13-15; Ap_Know: 1-2 Terms: composition of bone (tissue) Haversian systems compact vs. spongy bone red marrow osteo-cytes -blasts -clasts pattern of bone growth growth(epiphyseal) plateaxial skeleton appendicular skeleton non-movable joints, e.g., sutures synovial joints bursa cartilage ligament sprain arthritis osteoporosis MUSCULAR SYSTEM Chapter 6 The Muscular System all Pre_Ch_Q's:1-4 Cur_Iss: Does research support the hypothesis that taking anabolic steroids enhances strength? Cur_Iss: What is the main problem is determining with certainty the positive (or negative) effects of anabolic steroids? Hlth_Watch: This piece suggests that delayed onset muscle soreness (DOMS) is caused by damage to muscle. In lecture, it was pointed out that the most likely cause of DOMS is damage to ________________________. Concpt_Rev: 1-3,9; Match: 4-6; Fil_Blnk: 7-10; TF: all; Ap_Know: none;Terms: characteristics of skeletal muscle sarcomere sarcoplasm sarcolemma sarcoplasmic reticulum T-tubules actin and myosinoverall contractile process sliding filament theory the calcium connection motor unit neuro-muscular strength neuromuscular junction fast twitch fiber slow twitch fibervoluntary involuntary myogenic multi-unit smooth muscle single-unit smooth muscle cardiac muscle (refractory period) CARDIOVASCULAR SYSTEM Chapter 7 Blood: - pp. 138-145, 151,152 Pre_Ch_Q's: 1,2,3,4; Hlth_Watch: How would you rank the risks associated with giving/donating blood compared to receiving blood (e.g., receiving a blood transfusion)? Concpt_Rev: 1; Match: 1,2,4; Fil_Blnk: none; TF: none; Ap_Know: 1,2Terms: plasma formed elements red blood cell - erythrocyte hemoglobin hematocrit white blood cells plateletsanemia hemophilia leukemia carbon monoxide poisoning arteriosclerosis Chapter 8 Heart and Blood Vessels all Pre_Ch_Q's: 1-5; Table 8.2: What is the number one risk factor for high blood pressure (hypertension)? Concpt_Rev: 1,3-8; Match: 1-4; Label_Diag: 8-16; Fil_Blnk: 17,19,20; Ap_Know: Question # 1 is misleading as blood pressure does increase with exercise, why do you think blood pressure would increase with exercise, that is, what would cause it to increase?Terms: heart anatomy heart valves heart sounds (lub dub, murmurs) blood flow through heart pulmonary circuit systemic circuit coronary arteries angina myocardial infarctartery arteriole capillary vein varicose veins lymphatic system lymph vessels lymph nodescardiac output EKG cardiac cycle SA and AV node arrhythmias systolic blood pressure diastolic blood pressure hypertension stroke IMMUNE SYSTEM Chapter 9 The Immune System & Mechanisms of Defense: - pp. 180-204 Pre_Ch_Q's: 1-5; Hlth_Watch: How does breast feeding contribute to infants ability to defend against disease? Hlth_Watch: Why is it important to take ALL of the antibiotics given in your prescription in terms of bacterial resistance, i.e., what can happen if you dont? Concpt_Rev: 2-10; Match: 1-6; Fil_Blnk: 7-10; TF: 13-15; Ap_Know: 1-2 Chapter 7 Blood: - pp. 143-145, 145-147 Pre_Ch_Q's: 4; Concpt_Rev: 3,4,6,7; Match: 3,4,6; Fil_Blnk: 9,10,12; TF: 13,14; Terms: bacteria, (fungi), (protozoa) virus parasites antibiotics antibiotic (drug) resistance leukocytes eosinophils neutrophils monocytes macrophageslymphatic system lymphocytes (B & T) antigen antibody active immunity passive immunity vaccination non-specific immune inflammation lymphokines, e.g. histaminehumoral mediated immunity B cells plasma cells cell mediated immunity helper T cells killer T cells ABO blood type Rh factor allergies autoimmune disorders AIDS RESPIRATORY SYSTEM Chapter 10 The Respiratory System: Exchange of Gases 215-232 Pre_Ch_Q's: 1,2,(3) Hlth_Watch: What is the name of the procedure used to force food out of a persons respiratory passage when they are choking? Dir_Sci: What is the advantage of administering a drug via the respiratory passages? Concpt_Rev: 5-8; Match: 1-6; Fil_Blnk: 8,10,12; TF: 13-15; Ap_Know: noneTerms: trachea bronchi larynx alveoli diaphragm ventilation (vs. respiration) diffusion partial pressure of gassesmechanics of breathing regulation of ventilation carbon monoxide poisoning lung volume vs. function asthma emphysema bronchitis pneumonia NERVOUS SYSTEM Chapter 11 The Nervous System: Integration and Control pp. 236-252 Pre_Ch_Q's: (1-3) Hlth_Watch: In what ways to our (own) bodies contribute to spinal cord injury? Concpt_Rev: 3,4; Match: 1-6; Fil_Blnk: 8-11; TF:13; Terms: glial cells neuron structure body axon dendrite nerve (vs. neuron) cranial nerves spinal nerves action potential (aka conduction) synapse neurotransmitter, e.g., acetylcholinemyelin (and speed of conduction) motor (efferent) sensory (afferent) reflex CNS (central nervous system) PNS (peripheral nervous system) somatic nervous system autonomic nervous system sympathetic nervous system parasympathetic nervous system ENDOCRINE SYSTEM Chapter 13 The Endocrine System: - pp. 290-3008 (know basic function of endocrine glands) Pre_Ch_Q's: (1),2,3,(5) Hlth_Watch: What is the main distinction (problem) between Type I and Type II diabetes? Concpt_Rev: 2-5,8-10; Match: none; Fil_Blnk: 7-12; TF: 13-15; Ap_Know: 1,(2)Terms: endocrine glands and/or tissue hormone mechanism of hormone action secretion of hormone target tissue receptors feedback loop (positive and negative) half lifeneurohormones hypothalamus pituitary (master) gland primary endocrine glands and roles endocrine disorders and treatment diabetes hormones-like substances, e.g., prostaglandins, nitric oxide (NO), histamine DIGESTIVE SYSTEM Chapter 14 The Digestive System and Nutrition all Pre_Ch_Q's: 1,2,(3,4) Dir_Sci: Why is it that antibiotics are an effective treatment for stomach ulcers? Hlth_Watch: Low carb diets have come and gone over the last few years. What does research suggest about the short term and long term results of such diets? Concpt_Rev: 1,4-10 Match: 4,10; Fil_Blnk: 7,9-12; TF: 13-15; Ap_Know: 1-2Terms: digestive tract (general structure) mouth - function esophagus - function stomach - function gastric juice chyme small intestine -function large intestine function gall bladder - function pancreas function liver - functionsbile digestive enzymes, e.g., protease digestive hormones, e.g., secretin villi and microvilli regulation of digestion disorders; e.g., ulcer, hepatitis nutrients roles "essential" know your kcals! basic kcaloric requirements (%)carbohydrates - function fat - function protein - function vitamins - function minerals - function water function trace elements glycogen triglyceride saturated fats unsaturated fats food pyramid INTRODUCTION to ENERGY Chapter 3 Structure & Function of Cells section 3.7 (p 65-73) Concpt_Rev: 9,10; Match: 6; Fil_Blnk: 11.12; TF: 13-14; Ap_Know: noneTerms: energy work CHEMNL transformation of energy biological cycleATP producing pathways glycolysis Krebs cycle, citric acid cycle Electron transport chair aerobic anaerobic pathway lactic acid production lactic acid removalLecture - Human Energy Expenditure Try_It_Yourslf: (p. 333) What is the BMI (Body Mass Index) of a person that weighs 128 lbs and is 5 ft. 3 in. tall? According to Figure 14.18, what is their weight (health) status?Terms: energy balance daily energy expenditure basal metabolic rate (BMR) energy capacity of humans obesityideal body weight body mass index % body fat relative mortality weakness of weight indices URINARY SYSTEM Chapter 15 The Urinary System all. Pre_Ch_Q's: 1,(2),3,(4,5) Dir_Sci: It has been proposed that donating a kidney will result in health problems later in life. Is this idea supported by the most recent data related to the long-term health of kidney donors? Cur_Iss: How do the number of organs available compare to the number of organs needed over the last decade? Table 15.3 (p 347): According to the table, how much glucose is filtered per day? How much is reabsorbed? Should there normally be glucose in urine? Concpt_Rev: 1,2,7; Match: 1-6; Fil_Blnk: 9; TF: none; Ap_Know: 3Terms: anatomy of urinary system kidney, ureter, bladder, urethra anatomy of kidney cortex, medulla, nephron anatomy of nephron glomerulus Bowman's capsule special tubules role of blood vessels/circulationprocesses in urine formation diffusion, filtration, osmosis, active transport, permeability, reabsorption, tubular secretion filtrate control of urine volume - ADH hormone dialysis urinalysis other roles of kidney kidney stones HEREDITY Chapter 17 Cell Reproduction and Differentiation: - pp. 397-399 Pre_Ch_Q's: 3,5 Cur_Iss: What is the basic process involved in the cloning technique called somatic cell nuclear transfer? Concpt_Rev: 1,5; Match: 3,4; Fil_Blnk: none; TF: 13,14; Ap_Know: noneTerms: chromosome chromatid karyotype diploid haploid meiosis tetrads crossovergametes (sperm or egg ) gonads (testis or ovary) spermatogenesis [Ch 16; p. 364-366] oogenesis [Ch 16; p. 370-371] polar body zygote HEREDITY (continued) Chapter 19 Genetics and Inheritance: - all Pre_Ch_Q's: 1-5 Hlth_Watch: Cystic Fibrosis is the result of a recessive gene. What is the primary characteristic of this disorder as is relates to the lungs? Cur_Iss: What is the role of genetic testing in determining disease? Cur_Iss: What is the downside of genetic testing, i.e., potential harm that may be caused? Match: 1-6; Fil_Blnk: 7-12; TF: 13-15; Concpt_Rev: 1-10; Ap_Know: 1-2Terms: Mendelian principles gene locus allele dominant recessive homozygous heterozygousphenotypic ratio genotypic ratio Punnett Square autosomal sex chromosome polygenic inheritance incomplete dominance codominanceseX-linked inheritance chromosome inheritance deletion, duplication and translocation Klinefelter's syndrome Turner's syndrome Down's syndrome (trisomy)  MOLECULAR BASIS OF INHERITANCE (protein synthesis) Chapter 17 Cell Reproduction and Differentiation: - pp. 393-395 Concpt_Rev: 2,3,6,8,9,10; Match: 1,2,5,6; Fil_Blnk: 8; TF: none; Ap_Know: 2,3Terms: DNA detailed structure RNA detailed structure semi conservative replication transcription translation codon anticodontRNA rRNA mRNA protein synthesis exon operon inductionmutagen mutations chromosomal genetic germinal somatic genetic disease, e.g., PKU MOLECULAR BIOLOGY Chapter 20 DNA Technology and Genetic Engineering: - all (and lecture notes) Pre_Ch_Q's: 1-5; Dir_Sci: What is the basis of DNA fingerprinting, i.e., what do the restriction enzymes do, and how is it that they provide a fingerprint? Cur_Iss: What are the major points related to genetically modified food? Concpt_Rev: 5,7,8; Match: 1-5; Fil_Blnk: 11-20; TF: 6,9-12; Ap_Know: (1,2)Terms: genetic engineering applications recombinant DNA technique plasmids ethical aspects of genetic engineering     PAGE  PAGE 7 PAGE  8<=ghi~ ӿpZF4#hi5>*CJOJPJ\^JaJ'hdcVhv=5CJOJPJQJ^JaJ*hdcVhv=5CJOJPJQJ\^JaJhdcVh65CJOJQJ^JhdcVhw5CJOJQJ^JhdcV5CJOJQJ^JhdcVhv=5CJOJQJ^J"hdcVhv=5>*CJOJQJ^J'hdcVhv=5CJOJPJQJ^JaJ*hdcVhv=5CJOJPJQJ\^JaJhdcVhv=OJQJ^JhOJQJ^J8=S1 V`0X(` 0 h8p@xH!"6$gdv=. 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