ࡱ>  "` mbjbjss 4e$̇̇̇̇$ H J J J J J J $"h'%n  n   H  H pLX  ͑ṀZl 0 B%Hh%X X %X>މ, $.n n   $$$CG?$$$G$$$ Anatomy & Physiology Semester Exam Review Differentiate between anatomy and physiology Anatomy study of structure; physiology study of function; structure determines function List and explain the function necessary for maintaining life (characteristics of life) Responsiveness, conductivity, growth, respiration, digestion, absorption, secretion, excretion, circulation, reproduction List and describe the levels of organization within the body Subatomic particles ( atom ( molecule ( macromolecule ( organelle ( cell ( tissue ( organ ( organ system ( organism List the three basic components of every feedback control system Sensor (receptor), integrator (control center), effector Explain the mechanisms of action (overall goal) of negative and positive feedback control systems Negative to correct, stop, inhibit a change; positive stimulates a change Compare and contrast the following: superior/inferior, posterior/anterior, proximal/distal, lateral/medial. Be able to use these terms to describe parts of the body. Superior towards the head Inferior towards the feet Posterior back of the body Anterior front of the body Proximal towards the core of the body (referring to appendages) Distal away from the core (referring to appendages) Lateral away from the midline Medial towards the midline Name and describe the 3 planes used to divide the body Sagittal right & left halves Transverse superior and inferior halves Frontal or coronal anterior and posterior halves Differentiate between ionic and covalent bonds. Ionic electrons are transferred Covalent electrons are shared Explain the importance of water within the human body. What percentage of the body is water? Makes up 70% of the human body Distinguish between each of the 4 classes of organic molecules in terms of structure and function. Carbohydrates: Monomer monosaccharide Function energy for cellular activities Proteins: Monomer amino acid Function defense system (antibodies), receptor sites, structural support (skin, tendons, nails), enzymes, communication (insulin is a protein hormone) Lipids: Structure: glycerol & 3 fatty acid tails Function: concentrated energy source Nucleic Acids: Monomer: nucleotide (sugar, phosphate group, nitrogen base) Function: store genetic information (DNA), transfer genetic information (RNA) Differentiate between acids and bases. Acid any substance that releases H+ when in soluntion (proton donor); lowers pH Base any substance that increases the OH- concentration when dissociated in solution (proton acceptor); increases pH Discuss the structure and function of the following: endoplasmic reticulum, ribosomes, golgi apparatus, mitochondria, lysosomes, peroxisomes, cytoskeleton, cell fibers, centrosome, centrioles, cell extensions and nucleus. Endoplasmic reticulum: protein synthesis and intracellular transport Ribosomes: site of protein synthesis (cells protein factory) Golgi apparatus: processing and packaging plant; exports proteins made in rough ER Mitochondria: power plant; ATP is synthesized Lysosomes: digestive bags; rid cell of wastes Peroxisomes: detoxifying function; important to liver and kidneys Cytoskeleton: cell fibers, centrioles, centrosome Cell fibers: Microfilaments: cellular muscles Intermediate filaments: main components of the supporting framework in many cells Microtubules: cell engine help with movement within cell and of the cell itself Centrosome: microtubule-organization center; important in cell division b/c helps move chromosomes around the cell Centrioles: cylindrical structures within the centrosome; role in cell division Cell extension: Microvilli increase surface area; increases absorption (small intestine) Cilia transport fluid across cell surface (ex: respiratory tract, reproductive tract) Flagella aids in locomotion (ex: sperm cells) Nucleus: Cells brain; contains DNA; site of transcription Differentiate between embedded and peripheral proteins (structure and function). Embedded: penetrate the entire plasma membrane; transport mechanism; act as channels or gates Peripheral: identification markers (immune system); receptor sites Compare and contrast the processes of diffusion, dialysis, facilitated diffusion, osmosis and filtration. **All PASSIVE transport ** do NOT require energy ** occur DOWN a concentration gradient** Diffusion: tendency of small particles to spread out within a given space Dialysis: selectively permeable membrane separates small and large particles Facilitated diffusion: diffusion across a membrane with the help of a carrier protein (also called carrier-mediated passive transport) Osmosis: diffusion of water across a selectively permeable membrane Filtration: passive of water and permeable solutes through a membrane by the force of hydrostatic pressure Contrast isotonic, hypotonic and hypertonic solutions. Explain how they affect osmosis. **Refers to SOLUTE concentrations ** water will diffusion to area of HIGH solute concentration b/c there is a LOWER water concentration** Isotonic: ECF = ICF; no net movement of water Hypotonic: ECF < ICF; water diffuses into the cell; cell swells (remember hypO) Hypertonic: ECF > ICF; water diffuses out of the cell; cell shrinks Name and explain the 3 types of active transport discussed in class. **REQUIRE energy (ATP) ** occur AGAINST a concentration gradient (uphill)** Sodium-potassium pump: transports Na+ out of the cell and K+ into the cell; 3Na+ for 2K+ Endocytosis: brings large molecules into the cell Exocytosis: large molecules exit the cell Differentiate between the purines and pyrimidines. Purines: adenine & guanine Pyrimidines: cytosine & thymine How do the base pairs differ in RNA? Uracil replaces thymine (uracil binds with adenine) Explain the processes of transcription and translation. Transcription: DNA unzips RNA nucleotides attach themselves to the exposed bases along one side of the DNA molecule RNA polymerase binds RNA nucleotides Results in messenger RNA (mRNA) (transcript of the gene) mRNA pulls away from the DNA template non-coding portions (introns) are removed exons are spliced back together mRNA travels to cytoplasm via the nuclear pores Translation: Ribosomal subunits attach to one end of the mRNA Transfer RNA (tRNA) bring specific amino acids to the ribosomal site (based on each mRNA codon) Amino acids are joined together by polypeptide bonds Many polypeptide chains result in a protein What is the overall goal of mitosis? Production of TWO IDENDICAL daughter cells What are the phases of mitosis? What is occurring in each phase? (PMAT) Prophase: chromosomes shorten & thicken; nuclear envelope breaks down; spindle fiber formation Metaphase: chromosomes line up in the middle of the cell; spindle fibers attach at centromere Anaphase: spindle fibers pull sister chromatids away/apart from each other Telophase: cleavage furrow forms; nuclear envelope reappears What is the overall goal of meiosis? What is it referred to as reduction division? 2 haploid gametes; reduces the number of chromosomes from 46 to 23 List the 4 tissue types in the human body. Epithelial, connective, muscle, nervous Describe the function of each tissue type (general terms) Epithelial: protection (covers body surfaces), sensory, secretion (glandular epithelium), absorption (gut; respiratory tract exchange of O2 and CO2), excretion Connective: support, connection, transport, protection Muscle: move body, specialized for contraction Nervous: provides communication; coordinates bodys functions Name the 3 primary germ layers and state which tissue types develop from each layer Ectoderm nervous, epitherlial Mesoderm muscle, epithelial, connective Endoderm - epithelial Explain and apply the classification methods used to classify membranous epithelial tissues Cell Shape: Squamous: flat, plate-like Cuboidal: cube-shaped; larger cytoplasm Columnar: narrow and cylinder-shaped Pseudostratified: single-layered; all cells touch the basement membrane but may not extend to the top of the membrane Layers of Cells: Simple: single layer Stratified: cells are layered on top of one another Transitional: cell shape & layers differ Differentiate between endocrine and exocrine glands Exocrine glands: Discharge/secrete into ducts Ex: salivary glands Endocrine glands: ductless glands Secrete hormones directly into blood or interstitial fluid Ex: pituitary and thyroid glands Explain and apply the structural and functional classification methods for classifying exocrine glands Structural: Shape: tubular or alveolar (sac-like) Complexity: simple (one duct) or compound (multiple ducts) Functional: Apocrine Collect secretory products at apex (tip) Apex of cell pinches off Cell repairs itself & repeats process Ex: milk-producing mammary glands Holocrine Collect secretory product inside the cell Rupture to release (self-destructs) Ex: sebaceous glands (oil glands) Merocrine Discharge through plasma membrane This type applies to most exocrine glands Ex: salivary glands Describe the structure and function of the 4 types of connective tissues (remember the subtypes! study your flow chart!) **connective tissue is the most abundant tissue in the body** Fibrous Loose (areolar) Stretchable most abundant connective tissue in the body Connects adjacent structures Ex: btwn other tissues and organs Ex: superficial fascia Adipose Contains mainly fat cells Supportive/protection pads around kidneys & other body structures Storage deposit for excess food Insulating material, conserves body heat Reticular 3D web of reticular fibers Forms the framework of the spleen, lymph nodes & bone marrow Meshwork filters harmful substances out of the blood Dense Regular Fibers arranged in parallel rows Ex: tendons; ligaments Irregular Fibers intertwine; sustain stress from any direction Bone Cartilage Hyaline Most common Covers ends of long bones (where joints articulate) Found in supporting rings of respiratory tubes Fibrocartilage Strongest, most durable Intervertebral disks Menisci in knee joint Elastic Fine elastic fibers High degree of flexibility External ear Blood Matrix = plasma Formed elements = blood cells Function ( transport respiratory gases (O2, CO2), nutrients, wastes List the structural characteristics of skeletal, cardiac and smooth muscle tissue. Skeletal: voluntary, striations, multi-nucleated, long, tread-like cells, bundles of microfilaments Cardiac: striated, involuntary, intercalated disks (where plasma membranes meet up), branching Smooth: non-striated, involuntary, spindle-shaped cells, uninucleated List where the 3 types of muscle tissue can be found in the body: Skeletal muscles (attached to bone) Cardiac heart Smooth lines walls of hollow organs (stomach, intestines, blood vessels) What are the 3 main parts of a neuron? Explain the function of these 3 parts. Soma cell body; hold nucleus Dendrites carry signals towards soma Axon carry signals away from soma Which two tissue types have the greatest capacity for repair? Epithelial and connective How does connective tissue repair differ from epithelial tissue repair? Describe muscle tissue repair: Damaged muscle tissue is replaced by connective tissue; results in some or all loss of normal function Differentiate between benign and malignant tumors. Benign Tumors Do not spread to other tissues Slow growth Encapsulated Usually not lethal unless interfere w/ organs Malignant tumors (cancer) Not encapsulated Spreads (metastasizes) Cancer cells spread via blood or lymphatic system Rapid growth/spread to nearby tissue Complete the table relating to body membranes (you may need to refer to your textbook): MembraneTissue TypeCommon LocationsFunction(s)Mucous epithelial Line body surfaces open to exterior Ex: respiratory, digestive, urinary & reproductive tractsMucous which coats cells provides protection, lubrication for food & trap for contaminates in respiratory tractSerousepithelial Single membrane covering two surfaces: *Parietal membrane lines walls of body cavities *Visceral membrane covers surface of organs Secrete thin, watery substance to prevent rubbing Cutaneousepithelial Cover body surfaces exposed to external environment (skin) protectionSynovial connective Lines spaces btwn bones & joints*Secrete thick, colorless, lubricating fluid (synovial fluid) *Fluid helps reduce friction btwn bone surfaces  What does integument mean? What are appendages? What are the skins appendages? Integument = skin Appendages = attachments (hair, nails, skin glands) List and describe the 7 functions of the skin Protection from infection, dehydration, chemical/mechanical damage, ultraviolet radiation Sensation sensory receptors w/in skin Movement w/o injury elastic fibers allow movement & growth Excretion excretion of sweat; skin regulates volume & composition of sweat Endocrine function (vitamin D) - First steps of vitamin D production occurs in the skin when exposed to ultraviolet light Immunity langerhan cells in skin help trigger immune response Temperature regulation Vasoconstriction ( prevents heat loss ( warm blood circulating deeper within the body Vasodilation ( increases heat loss ( increases skins blood supply ( heat lost to the external environment Differentiate between thick and thin skin. (Remember these terms only apply to the epidermis). Thin skin covers most of body surface Thick skin palms of hands, soles of feet, finger tips All 5 layers of epidermis present Raised dermal papillae (fingerprints or footprints) No hair is present in thick skin What are the two main layers of skin? Briefly describe the characteristics of these two layers. Which layer is vascular? Avascular? Epidermis Avascular Outer, thinner layer 5 layers Thick & thin (see #40) 3 cell types (see #42) 5 strata (layers) see #43 Dermis Vascular true skin Thicker than epidermis Protective function against mechanical injury Storage area for water and electrolytes Contains somatic sensory receptors (nerves & nerve endings) Process information such as: pain, pressure, touch, temperature Muscle fibers, hair follicles, sweat & sebaceous glands, blood vessels List and describe the 3 cell types of the epidermis. Keratinocytes: synthesize keratin Melanocytes: synthesize melanin (brown pigment gives skin color) Melanin: protects deeper layers from ultraviolet light Langerhan cells (immune cells) Provide defense mechanism for the body List and describe the 5 strata of the epidermis. Which layers are found only in thick skin? Where does keratinization begin? Which layer does mitosis take place in? Stratum corneum (horny layer) Most superficial Shingle-like (squamous) dead cells Stratum lucidum (clear layer) Only in thick skin Stratum Granulosum (granular layer) Keratinization begins here Stratum spinosum (spiny layer) 8-10 layers of irregular shaped cells Stratum basale (base layer) Single layer of columnar cells Mitosis occurs here How are goose bumps produced? Contraction of the arrector pili muscles What causes us to have distinct fingerprints and footprints? Dermal papillae bumps that project into epidermis Creates distinct ridges on epidermal surface of fingers & toes (finger/footprints) unique for every person in papillary layer of dermis How does the vascular supply within the dermis play a role in the regulation of body temperature? Vasocontriction: prevents heat loss ( warm blood circulating deeper within the body Vasodilation: increases heat loss ( increases skins blood supply ( heat lost to the external environment Negative feedback mechanism What is the significance of cleavage lines? If a surgeon cuts along a cleavage line there will be less incidence of a scar; cutting perpendicular to the cleavage line will cause increased stress on the incision which increases healing time and increases visibility/incidence of a scar How do the quantity of melanocytes and the amount of melanin produced differ in people of different skin colors? Quantity of melanocytes is constant among all races; amount of melanin produced differs Describe the two rules for estimating the body surface area affected by a burn. Rule of palms the size of the patients palm is approximately 1% of their body surface Rule of nines Body surface divided into 11 areas (anterior and posterior) of 9% (see figure in book) Perineum (genital area) accounts for 1 % Describe the structure of hair (fig 6-10) Describe the function of sebaceous glands. Why are teenagers going through puberty more prone to acne? Secrete oil for skin & hair Activated at puberty (stimulated by sex hormones) Explains why teenagers are prone to acne List and describe the 5 function of bones. Support - Shape, alignment, positioning of body parts Protection - Protects organs Movement - Bones and joints act as levers; Muscles attached to bones produce movement of joints Mineral storage - Calcium and phosphorous; Homeostasis of blood calcium levels Hematopoiesis - Blood cell formation What are the 2 types of skeletal tissue? Give a brief description of each type. Compact bone Dense or solid appearance Cancellous or spongy bone Open spaces filled with needle-like bone structures List and describe the parts of a long bone. Diaphysis Shaft of the bone Hollow, compact bone Epiphyses Ends of the long bones Points of muscle attachment Stability to joints Spongy bone filled with red marrow Epiphyseal plate: area between diaphysis and epihyses (growth plate) Articular cartilage Hyaline cartilage that covers joint surfaces Periosteum Dense, white fibrous membrane that covers bone (excepts joint surfaces) Tendon fibers interlace with these fibers creating a firm attachment Medullary (marrow) cavity Hollow space in diaphysis of long bones Filled with yellow marrow (CT rich in fat) Endosteum Epithelial membrane that lines the medullary cavity Bones can be classified into 4 groups based on their structure. List the four groups; give a brief description of each group and examples of each group. Long bones typically longer than wide Have shaft w/ heads at both ends contains mostly compact bone Ex: femur, humerus, ulna, radius Short bones Cube or box-shaped Mostly spongy bone Ex: carpals & tarsals Flat bones Thin, flattened Usually curved surface Thin layer of compact bone covering spongy bone Ex: ribs, skull, sternum, scapulae Bone marrow aspirations occur here Irregular bones Various shapes/sizes Do not fit into other categories Ex: vertebrae, facial bones Sesamoid bones: occur singularly (ex: patella) How are fractures repaired? What must occur for this process to be successful? Vascular damage initiates repair sequence Vascular damage ( hemorrhage ( blood clot (fracture hematoma) Hematoma resorbed ( callus Callus replaced by normal bone tissue **proper alignment & immobilization are necessary for healing to occur** How does stress on bones affect the arrangement of the trabeculae? Bony spicules of spongy bone arrange along lines of stress Varies for different types of bone What is the structural unit of compact bone? List and describe the 4 components of an osteon. Osteon Lamellae: concentric, cylinder-shaped layers of calcified matrix Lacunae (little lakes): small spaces filled with tissue fluid which hold bone cells Canaliculi: very small canals connecting lacunae together Haversian canal: extend lengthwise through the center of an osteo What are volkmanns canals? Volkmanns canal: (not part of osteon) transverse canals containing nerves and blood vessels Carry blood from exterior surface of bone to osteons Be familiar with the names of the 7 tarsals. Calcaneous (heel bone), navicular, cuniforms (3), talus, cuboid How many vertebrae make up the cervical, thoracic and lumbar sections of the vertebral column? What is the correct order from superior to inferior? Cervical 7 Thoracic 12 Lumbar 5 Explain the function of the foramen magnum. Hole through which the spinal cord enters the skull Explain how joints can be classified both functionally and structurally. Structural Fibrous Cartilaginous synovial Functional Synarthroses Amphiarthroses diarthroses What degree of movement is permitted in each category of joints (Table 9-1). Synarthroses/fibrous immovable (some slightly movable) Amphiarthroses/cartilaginous (slightly movable) Diarthroses/synovial freely moveable Describe how the three categories of joints are subdivided. What are the characteristics of each subcategory? Be able to identify examples. Synarthroses/fibrous immovable Syndesmoses fibrous bands connect two joints (ex radioulnar interosseous ligament) Sutures sutures in skull Gomphoses tooth socket Amphiarthroses/cartilaginous (slightly movable) Synchondroses hyaline cartilage (ex: epiphyseal plates) Symphyses fibrocartilage (ex: symphysis pubis) Diarthroses/synovial freely moveable Uniaxial: (move around one axis or one plane) Hinge: knee, elbow Pivot: atlas pivoting around axis (dens) Biaxial (move around 2 axes or 2 planes) Saddle joint: thumbs Condyloid (ellipsoidal): radius & carpal bones Multiaxial (move around 3+ axes or 3+ planes) Ball & socket: hip, shoulder Gliding: btwn successive vertebrae Compare the hip and humeroscarpular joint (shoulder) in terms of mobility and stability. What causes this difference? Hip ( more stable; less mobile; deep joint cavity Shoulder ( less stable; more mobile; due to shallow joint cavity Describe the structure and function of menisci. Pads of fibrocartilage located btwn articulating ends of bones in some diarthroses Be able to explain and identify examples of the following types of movements: Angular Flexion decrease the angle Extension increase the angle Hyperextension increase the angle beyond 180 degrees Abduction movement of appendages away from the midline Adduction movement of the appendages towards the midline Plantar flexion pointing the toe towards the ground (planting the toe) Dorsiflexion pointing the toe towards the sky (walking on your heels) Circular Rotation rotating on an axis (atlas on the axis shaking your head no) Circumduction making circles with appendage or body part Supination twisting the palms outward (making a bowl of soup) Pronation twisting the palms inward (passing a basketball) Special Inversion soles of feet face inward (towards midline) Eversion soles of feet face outward (lateral) Protraction pushing a body part forward (push jaw forward under bite) Retraction pulling a body part back into place (correcting the under bite) Elevation raising a body part (ex: closing the mouth raising the mandible) Depression lowering a body part (ex: opening the mouth lowering the mandible) What are the 3 function of muscle? Movement, heat production, posture Describe the specialization of a muscle fiber: specialized organelles, number of nuclei?, number of nuclei, number of mitochondrion? Plasma membrane = sarcolemma Cytoplasm = sarcoplasm Sarcoplasmic reticulum = network of tubules and sacs (analogous to endoplasmic reticulum) Multinucleated Multiple mitochondria (directly related to energy needs of the muscle fiber; ex: athletes muscle fibers will have more mitochondria compared to someone w/ a sedentary lifestyle) Explain the organization of a muscle (from muscle to myofilaments) Muscle ( fascicle ( muscle fiber ( myofibril ( myofilament (thick and thin) What is a sarcomere? Contractile unit of a muscle fiber Describe excitability, contractility and extensibility. Excitability ability of a muscle fiber to become stimulate by a nerve impulse Contractility ability of a muscle fiber to contract or shorten Extensibility ability of a muscle fiber to relax or extend back to its resting position What is the purpose of the t-tubules? What is a triad? Brings the nerve impulse deeper into the muscle fiber to simulate the sarcoplasmic reticulum A triad is a t-tubule surrounded by two sacs of sarcoplasmic reticulum What is the role of acetylcholine in skeletal muscle contractions? The role of calcium? Acetylcholine stimulates the scarolemma causing a nerve impulse to travel along the muscle fiber Calcium is binds with troponin causing tropomyosin to expose the actin binding sites for myosin (cross bridges can occur) Where does the body get energy for muscle contractions? Is there an alternate source? 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