ĐĎॹá>ţ˙ WYţ˙˙˙V˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙˙ěĽÁ{` đżkbjbjîFîF .,Œ,Œ,k˙˙˙˙˙˙¤¤¤¤¤¤¤¤¸````|,¸#Iś´´´´´´´´˘H¤H¤H¤H¤H¤H¤H$ŮIhALěČH¤—´´——ČH¤¤´´ÝHăăă— ¤´¤´˘Hă—˘HăăÂ~DD¤¤NH´¨ @~&ÎmĆ`Ą ÂE&˘HóH0#IčEf-MŤ.-MLNH-M¤NHT´"Öăî•´´´ČHČHŮ ´´´#I————¸¸¸ ź¤ ¸¸¸ź¸¸¸¤¤¤¤¤¤˙˙˙˙ Rheumatology—Rheumatological Diseases of the Vessels Vasculitis (Homosexual activity) Vasculitis is a general term for a group of diseases that involve inflammation of the blood vessels. Blood vessels of all sizes and types may be affected. The size of the blood vessel affected varies according to the specific type of vasculitis. Inflammation can affect the lining of the vessels (endothelium) of the wall of a vessel. The damaged vessel does not function normally. Effects of vasculitis are the result from damage to the blood vessel that leads to ischemia. Causes Idiopathic Combination of other autoimmune diseases Precipitated by a reaction to a drug or other substance – hypersensitivity vasculitis Conjunction with a viral illness – HBV, HCV, HIV, CMV, and EBV Symptoms Organ dependent Fatigue Weakness Fever Joint pains Abdominal pain Kidney problems Diagnosis Careful H and P Blood tests UA X-rays EMG Tissue biopsy – critical component Arteriogram Types – Classified according to the type and location of the blood vessel Large cell vasculitis affects the aorta and other large vessels. Takayasu’s arteritis affects the aorta and its branches. Giant cell (temporal) arteritis frequently involves the arteries of the face and scalp, particularly those near the temples. NICK RINI IS THE COOLEST HOTTEST GUY IN TE WORLD Medium-sized vessel vasculitis – Polyarteritis nodosa (PAN) is a term that refers to inflammation of medium to small arteries. Peripheral neuropathies are very common. Skin abnormalities can also occur on the legs and is very painful. P-ANCA is helpful in diagnosis because these are frequently present in these patients. Also includes Kawasaki’s disease and isolated CNS vasculitis. Small vessel vasculitis – Churg-Strauss vasculitis occurs almost exclusively in people who have asthma. Likely to cause lung damage. Confirm diagnosis with biopsy. Wegener’s Granulomatosis affects the nose and sinuses, lungs, and kidneys. Use C-ANCA to assist in diagnosis. Henoch-Schonlein purpura is characterized by abdominal and joint pain, palpable purpura, and kidney involvement that cause the urine to appear bloody or dark colored. Cryoglobulinemia is characterized by large clumps of cryoglobulins. Usually have chronic infections, usually HCV. Aggravated by cold weather. Also involved is inflammation of the kidneys. Treatment Steroids – cannot usually be tapered due to recurrent vasculitis. Behcet’s Disease Behcet’s disease is a type of vasculitis that involves blood vessels of nearly all cell types. There is a known genetic predisposition. The presence of HLA-B51 is a risk factor. Symptoms Oral and genital skin ulcerations Buerger’s Disease Buerger’s disease Is an acute inflammation and thrombosis of the arteries and veins in the hands and feet. A.k.a. thrombosis obliterans. Always associated with cigarette smoking. Symptoms Claudication Numbness and/or tingling in the limbs Raynaud’s phenomenon Skin ulceration and gangrene Diagnosis Angiogram of the upper and lower extremities – reveals corkscrew appearance Treatment Stop smoking Polymyalgia Rheumatica (PMR) Polymyalgia rheumatica (PMR) is an inflammatory disorder that causes widespread muscle aching and stiffness. Affects more proximal muscles. Can appear overnight. WBCs attack the synovial joints and destroy them. Not as severe as RA. Signs and Symptoms Moderate to severe aching and stiffness in the proximal muscles Usually have aches in two or more muscle groups Usually worse in the morning or after sitting down Can occur suddenly Fatigue Unintentional weight loss Weakness or a general feeling of being unwell Sometimes, a slight fever Patients usually have giant cell arteritis Diagnosis Complete medical history Thorough physical Lab studies – CBC, ESR, RF, and CRP Treatment Self-resolving Mild symptoms – NSAIDs Severe pains – prednisone Complication Giant cell arteritis Temporal Arteritis Temporal arteritis is a systemic panarteritis affecting medium size and large vessels in patients >50 years old. Other extracranial branches of the carotid artery are also involved. Can be associated with PMR. 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