ࡱ> VZU{ ebjbj88 42ZfZf3 1 00000DDD8|<DD<($$$<<<<<<<$?AH7<07<00$$L<R0$0$<<#46$NeR4;b<0< 5D|D466nD067<7<3X<D X : Possible Side Effects of FOLFOX (Leucovorin, 5-Fluorouracil, Oxaliplatin) (Table Version Date: October 23, 2020) COMMON, SOME MAY BE SERIOUS In 100 people receiving FOLFOX (Leucovorin, 5-Fluorouracil, Oxaliplatin), more than 20 and up to 100 may have:Hair loss Hand-foot syndrome (palmar-plantar erythrodysesthesia) redness, pain or peeling of palms and soles Rash, increased risk of sunburn, itching Diarrhea, nausea, vomiting, constipation, loss of appetite Difficulty swallowing Sores in mouth Heartburn Infection, especially when white blood cell count is low Anemia which may require a blood transfusion Bruising, bleeding Headache Tiredness Numbness, tingling or pain, "pins and needles" of the hands, feet, arms and legs Tingling or a loss of feeling in your hands, feet, nose, or tightness in throat or jaw, or difficulty swallowing or breathing which may be made worse by exposure to cold Cough Fever, pain OCCASIONAL, SOME MAY BE SERIOUS In 100 people receiving FOLFOX (Leucovorin, 5-Fluorouracil, Oxaliplatin), from 4 to 20 may have:Chest pain Abnormal heartbeat which may cause fainting Swelling and redness at the site of the medication injection Hives Skin changes Weight gain, weight loss, belly pain Internal bleeding which may cause black tarry stool, blood in vomit or urine, or coughing up blood Changes in taste Blood clot which may cause swelling, pain, shortness of breath Bleeding from multiple sites including vaginal bleeding, bleeding of the testis, or bleeding of the brain Liver damage which may cause yellowing of eyes and skin Allergic reaction which may cause rash, low blood pressure, wheezing, shortness of breath, swelling of the face or throat Change in voice Confusion, dizziness Muscle weakness Inability to move shoulder or turn head Blurred vision, watering eyes Discomfort from light Abnormal body movement including the eye and eyelid Difficulty walking, using your hands, opening mouth, talking, with balance and hearing, smelling, eating, sleeping, emptying the bladder Hearing loss Swelling of the body which may cause shortness of breath Kidney damage which may require dialysis Scarring of the lungs Blockage of the airway which may cause shortness of breath, cough, wheezing Dehydration RARE, AND SERIOUS In 100 people receiving FOLFOX (Leucovorin, 5-Fluorouracil, Oxaliplatin), 3 or fewer may have:Damage to the heart which may cause shortness of breath A new cancer resulting from treatment of a prior cancer Stevens-Johnson syndrome which may cause severe skin rash with blisters and peeling which can involve the mouth and other parts of the body     Page  PAGE 1 of  NUMPAGES 2 !-J_cgimoqɽɮեՆwhwwYIh]=hYh`h["CJOJQJaJh["CJOJQJaJh&CJOJQJaJh]=hQCJOJQJaJh]=h?DEKLǻǬydTdhxrh "5CJOJQJaJ(jhxrh "5CJOJQJUaJhxrh "CJOJQJaJh!Ajh!AUh]=h#>aJh]=hQCJOJQJaJh]=h/CJOJQJaJhs CJOJQJaJhb hs CJOJQJaJh]=h|L,CJOJQJaJh]=hi7CJOJQJaJh'(CJOJQJaJ1235689;<>?bcdey$a$gdaJh!Ah "hxrh "CJaJhxrh "5CJOJQJaJhxrh "CJOJQJaJ(jhxrh "5CJOJQJUaJ$h3l5CJOJQJaJmHnHu 21:pQ/ =!"#$%` $$If !vh#v):V l44 t065)a f4p ytq x$$If !vh#v):V l t065)a ytg$$If !vh#v):V l44 t065)a f4p ytq x$$If !vh#v):V l t065)a ytg$$If !vh#v):V l44 t065)a f4p ytq x$$If !vh#v):V l t065)a ytg x666666666vvvvvvvvv66666>666666666666666666666666666666666666666666666666hH666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@66666 OJPJQJ_HmH nH sH tH J`J VNormal$a$OJPJQJ_HmH sH tH N@N }e Heading 1@&CJOJQJaJmHsHtHDA D Default Paragraph FontRi@R 0 Table Normal4 l4a (k ( 0No List :) : V Page Number CJOJQJ@@ VHeader ! mHsHtHF/F V Header CharCJOJPJQJ^JaJ@ @"@ V0Footer ! mHsHtHF/1F V0 Footer CharCJOJPJQJ^JaJR^@BR V Normal (Web)dd[$\$a$ CJOJQJRRR V List Paragraph ^a$m$CJOJQJaJjcj Q Table Grid7:V0PrP Q0 Balloon TextCJOJQJaJmHsHtHR/R Q0Balloon Text CharCJOJPJQJ^JaJB' B 10Comment ReferenceCJaJ@@ 10 Comment Text mHsHtHR/R 10Comment Text CharCJOJPJQJ^JaJ@j@ 10Comment Subject5\^/^ 10Comment Subject Char5CJOJPJQJ\^JaJH/H }eHeading 1 CharCJOJPJQJaJ8W`8 2!5`Strong5CJOJQJaJPK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭Vj\{cp/IDg6wZ0s=Dĵw %;r,qlEآyDQ"Q,=c8B,!gxMD&铁M./SAe^QשF½|SˌDإbj|E7C<bʼNpr8fnߧFrI.{1fVԅ$21(t}kJV1/ ÚQL×07#]fVIhcMZ6/Hߏ bW`Gv Ts'BCt!LQ#JxݴyJ] C:= ċ(tRQ;^e1/-/A_Y)^6(p[_&N}njzb\->;nVb*.7p]M|MMM# ud9c47=iV7̪~㦓ødfÕ 5j z'^9J{rJЃ3Ax| FU9…i3Q/B)LʾRPx)04N O'> agYeHj*kblC=hPW!alfpX OAXl:XVZbr Zy4Sw3?WӊhPxzSq]y e "2 0003 Le   41e +-3!L# @0(  B S  ?*<3 5 6 8 9 ; < > ? 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