ࡱ>  _aVWXYZ[\]^gbjbjcTcT>>"ll"""""DB#B#B##n&B#26 6?:p?p??zATX^P$Z5"fXA"zAff5""p??J0uuuf"8p?"?ufuuUT"-?IoB#lhz<m-,YJ"X @b4cucnd8@b@b@b55Fup@b@b@bffff@b@b@b@b@b@b@b@b@bl t!: Guidance for Industry on Providing Regulatory Information in Electronic Format: Non-eCTD electronic Submissions (NeeS) for human medicinal products This document is published under the auspices of the EU Telematics Implementation Group for electronic submissions (TIGes) Version 2.0 March 2010 Content  TOC \o "1-4" \h \z \u  HYPERLINK \l "_Toc255322944" Content  PAGEREF _Toc255322944 \h 2  HYPERLINK \l "_Toc255322945" 1 Introduction  PAGEREF _Toc255322945 \h 3  HYPERLINK \l "_Toc255322946" 2 General considerations  PAGEREF _Toc255322946 \h 3  HYPERLINK \l "_Toc255322947" 2.1 Scope  PAGEREF _Toc255322947 \h 3  HYPERLINK \l "_Toc255322948" 2.1.1 Types of procedures  PAGEREF _Toc255322948 \h 3  HYPERLINK \l "_Toc255322949" 2.1.2 Type of product  PAGEREF _Toc255322949 \h 3  HYPERLINK \l "_Toc255322950" 2.1.3 Type of submission  PAGEREF _Toc255322950 \h 3  HYPERLINK \l "_Toc255322951" 2.1.4 Exceptions  PAGEREF _Toc255322951 \h 3  HYPERLINK \l "_Toc255322952" 2.2 Structure of submissions  PAGEREF _Toc255322952 \h 3  HYPERLINK \l "_Toc255322953" 2.2.1 Table of Contents  PAGEREF _Toc255322953 \h 4  HYPERLINK \l "_Toc255322954" 2.3 Submission numbering  PAGEREF _Toc255322954 \h 5  HYPERLINK \l "_Toc255322955" 2.4 Moving to NeeS format applications  PAGEREF _Toc255322955 \h 5  HYPERLINK \l "_Toc255322956" 2.5 General Submission Considerations  PAGEREF _Toc255322956 \h 5  HYPERLINK \l "_Toc255322957" 2.5.1 File and folder structure  PAGEREF _Toc255322957 \h 5  HYPERLINK \l "_Toc255322958" 2.5.2 File Naming  PAGEREF _Toc255322958 \h 5  HYPERLINK \l "_Toc255322959" 2.5.3 Placement of Documents  PAGEREF _Toc255322959 \h 6  HYPERLINK \l "_Toc255322960" 2.6 Correspondence  PAGEREF _Toc255322960 \h 6  HYPERLINK \l "_Toc255322961" 2.7 Paper requirements  PAGEREF _Toc255322961 \h 6  HYPERLINK \l "_Toc255322962" 2.8 Hardware  PAGEREF _Toc255322962 \h 6  HYPERLINK \l "_Toc255322963" 2.9 File formats  PAGEREF _Toc255322963 \h 6  HYPERLINK \l "_Toc255322964" 2.9.1 PDF  PAGEREF _Toc255322964 \h 6  HYPERLINK \l "_Toc255322965" 2.9.2 Extensible Mark-up Language (XML)  PAGEREF _Toc255322965 \h 6  HYPERLINK \l "_Toc255322966" 2.9.3 Other File Formats  PAGEREF _Toc255322966 \h 7  HYPERLINK \l "_Toc255322967" 2.10 Bookmarks and hypertext links  PAGEREF _Toc255322967 \h 7  HYPERLINK \l "_Toc255322968" 2.11 Technical validation of NeeS submissions  PAGEREF _Toc255322968 \h 7  HYPERLINK \l "_Toc255322969" 2.12 Other Technical Information  PAGEREF _Toc255322969 \h 7  HYPERLINK \l "_Toc255322970" 2.12.1 Security issues  PAGEREF _Toc255322970 \h 7  HYPERLINK \l "_Toc255322971" 2.12.2 Password protection  PAGEREF _Toc255322971 \h 7  HYPERLINK \l "_Toc255322972" 2.12.3 Virus protection  PAGEREF _Toc255322972 \h 8  HYPERLINK \l "_Toc255322973" 2.12.4 Electronic signatures  PAGEREF _Toc255322973 \h 8  HYPERLINK \l "_Toc255322974" 2.12.5 Transmission Media  PAGEREF _Toc255322974 \h 8  HYPERLINK \l "_Toc255322975" 2.12.6 Labelling of Media:  PAGEREF _Toc255322975 \h 8  HYPERLINK \l "_Toc255322976" 2.12.7 Procedure for sending electronic information  PAGEREF _Toc255322976 \h 9  HYPERLINK \l "_Toc255322977" 2.12.8 Archiving and working copies  PAGEREF _Toc255322977 \h 9  HYPERLINK \l "_Toc255322978" 3 Module specific information  PAGEREF _Toc255322978 \h 9  HYPERLINK \l "_Toc255322979" 3.1 Module 1.2: Administrative Information (Application Forms)  PAGEREF _Toc255322979 \h 9  HYPERLINK \l "_Toc255322980" 3.2 Module 1.3.1: Product Information  PAGEREF _Toc255322980 \h 9  HYPERLINK \l "_Toc255322981" 3.3 Module 1-responses  PAGEREF _Toc255322981 \h 9  HYPERLINK \l "_Toc255322982" Annex 1. Guidance on Text Searchable Documents  PAGEREF _Toc255322982 \h 10  HYPERLINK \l "_Toc255322983" 1. General  PAGEREF _Toc255322983 \h 10  HYPERLINK \l "_Toc255322984" 1.1 Creating Text Searchable Files  PAGEREF _Toc255322984 \h 10  HYPERLINK \l "_Toc255322985" 2. Documents that must always be text searchable  PAGEREF _Toc255322985 \h 10  HYPERLINK \l "_Toc255322986" 3. Documents that do not need to be text searchable  PAGEREF _Toc255322986 \h 11  HYPERLINK \l "_Toc255322987" 4. Further Information  PAGEREF _Toc255322987 \h 11  HYPERLINK \l "_Toc255322988" Annex 2. Example Tables of Contents  PAGEREF _Toc255322988 \h 12  HYPERLINK \l "_Toc255322989" Module 1  PAGEREF _Toc255322989 \h 12  HYPERLINK \l "_Toc255322990" Module 2  PAGEREF _Toc255322990 \h 14  HYPERLINK \l "_Toc255322991" Module 3  PAGEREF _Toc255322991 \h 15  HYPERLINK \l "_Toc255322992" Module 4  PAGEREF _Toc255322992 \h 17  HYPERLINK \l "_Toc255322993" Module 5  PAGEREF _Toc255322993 \h 19  HYPERLINK \l "_Toc255322994" Document Control  PAGEREF _Toc255322994 \h 21  1 Introduction In 2005 the Heads of Medicines Agencies agreed that all Member States would be able to accept electronic-only submissions, without accompanying paper copies, by the end of 2009. Some NCAs did not reach the target by this year but the work will continue. The benefits of moving to e-working are considered to be: Reduction of (internal) paper-flow (logistics and administrative burden), Reduction of physical archiving space, Facilitation of the review process. This Guidance Document is intended to assist pharmaceutical companies with the submission of regulatory information in electronic format to the National Competent Authorities (hereafter referred to as NCAs). This document details the requirements for the submission of Non-eCTD electronic Submissions (NeeS). A separate EU guidance document covering HYPERLINK "http://esubmission.ema.europa.eu/doc/eCTD%20Guidance%20Document%201.0%20FINAL%20FOR%20PUBLICATION.pdf"eCTD submissions has also been published on the EMA eSubmission website. This document has been created by the Harmonisation Group, a sub-group of the Telematics Implementation Group for electronic submissions (TIGes), and been adopted for publication by the TIGes. It is strongly recommended that all National Competent Authorities adopt this guidance as the basis for their dealings with applicants when using the NeeS format. It should be stressed that this Guidance Document reflects the current situation and will be regularly updated in the light of changes in national and/or European legislation together with further experience gained within NCAs of using information submitted in electronic format. It should be emphasised that NeeS applications should be regarded as an interim format and that applicants should be actively planning their move to full eCTD submissions. 2 General considerations 2.1 Scope 2.1.1 Types of procedures This guidance covers applications made in National, Mutual Recognition and Decentralised procedures. 2.1.2 Type of product The product types include small molecules, herbals, vaccines, homeopathics and blood products for human medicinal products falling within the competence of NCAs. This includes prescription and over the counter medicines, innovative and generic product submissions. 2.1.3 Type of submission This guidance applies to all submissions related to the authorisation and maintenance of medicinal products, including new marketing authorisations, variations, renewals, PSURs and active substance master files. Exceptions This guidance does not apply to the electronic submission of pre-MA information such as scientific advice, clinical trial applications, briefing packages and related submission correspondence. Structure of submissions Regulatory information must be structured in accordance with the HYPERLINK "http://ec.europa.eu/enterprise/sectors/pharmaceuticals/documents/eudralex/index_en.htm"Common Technical Document (CTD), which for paper submissions became mandatory in the European Union with effect from 1 July 2003. For NeeS applications the eCTD folder structure is used. The breakdown of the electronic submission should be in conformity with the ICH Granularity Document and the ICH and EU eCTD file naming conventions should be followed. (Links are found at  HYPERLINK "http://esubmission.ema.europa.eu/doc/index.html" EMA eSubmission website.) The difference from an eCTD is that the two relevant XML files, the index.xml and eu-regional.xml for the backbone of Modules 2 to 5 and Module 1 for the EU, respectively and the util folder are not present, so navigation through a NeeS is based on electronic Tables of Content, bookmarks and hypertext links. Typically, a NeeS application will cover all dosage forms and strengths of a product with any one invented name. In MRP/DCP, a single NeeS application should preferably be used for each procedure (e.g. UK/H/1003/001-002/DC). However, if the applicant decides to have one NeeS per strength or dosage form, this would also be acceptable but should be carefully considered in relation to transformation into eCTD at a later stage. 2.2.1 Table of Contents and bookmarks Some NCAs have a tool with which they create their own TOCs. However, TOCs should still always be provided by the applicant. The TOCs should always be submitted in PDF format. All documents in the NeeS dossier should be referenced from a hyperlinked Table of Contents (TOC). Hyperlinks for each document should always be provided to the first page of the appropriate file. In the case of small dossiers (e.g. for certain variations), especially when only one module beside module 1 is concerned, it should be acceptable to only include a main TOC referring directly to the content documents. However, for larger submissions, the main TOC should always be linked to module TOCs which are then further linked to the documents in each module. The module TOCs should not include hyperlinks to documents in other modules. The file containing the main Table of Contents for the CTD should be named ctd-toc.pdf and be located in the top level folder for the NeeS submission. The files containing the module Tables of Content should be named m1-toc.pdf, m2-toc.pdf, m3-toc.pdf, m4-toc.pdf and m5-toc.pdf and be located in the corresponding top level module folder. An example is presented in HYPERLINK \l "_Annex_2_Example"Annex 2. It should be noted that these are just examples and are provided for guidance and illustrative purposes only. Where document TOCs are included they should be located within the same file as the rest of the document. For each document, provide bookmarks for every entry in the document's Table of Contents to the appropriate location, or where a Table of Contents does not exist, provide bookmarks to a sufficiently detailed level, typically to Level 3 or 4 headings, as considered appropriate. An additional function might be provided to allow easy navigation back to the Table of Contents above. This can be achieved through the use of a bookmark linked back to the previous level. This additional function is not mandatory, but when provided it will facilitate the assessment. The figure below describes diagrammatically this situation.  Submission numbering Sequence numbers, as they are defined for eCTD submissions, are not applicable for NeeS submissions. The use of a four digit number in the top level folder name is however recommended. The number does not have to be unique. Moving to NeeS format applications A NeeS format application can normally be started with any initial, variation or renewal MA application. Once the switch to this electronic format is made it is expected that further applications and responses relating to the particular medicinal product are submitted in the same electronic format or in the up-graded full eCTD format. Since there is no life cycle management for NeeS, there is no need to reformat the whole dossier into NeeS format when switching from paper to NeeS, but this could be done at the applicants discretion. It should then be clearly stated in the cover letter of the reformatted dossier that the content has not been changed, but only its format. Applicants should not change from eCTD back to NeeS. In exceptional circumstances, if this should be needed, please contact the concerned NCAs in advance. General Submission Considerations 2.5.1 File and folder structure Submissions are a collection of documents and each document should be provided as a separate file. The detailed structure of the NeeS should conform to the  HYPERLINK "http://www.ich.org/MediaServer.jser?@_ID=554&@_MODE=GLB"ICH Granularity Document and  HYPERLINK "http://ec.europa.eu/enterprise/sectors/pharmaceuticals/documents/eudralex/vol-2/index_en.htm" EU M1 specifications. NCAs have a distinct preference for naming the root folder of the submission with the product (invented) name in lower case or procedure number followed by the subfolder, name, e.g. mydrug/0000/ or de-h-01234/0000/. Total folder/file path should not exceed 180 characters. 2.5.2 File Naming The eCTD file naming conventions described in the ICH M2 eCTD Specification and EU Module 1 Specification should be followed. If an applicant wishes to submit multiple files in one section, where only one highly recommended name is available, this can be achieved using a suffix to the filename, using the file name-var.pdf convention as described in the EU Module 1 Specification, where the -var component has no dashes or illegal characters (e.g. pharmaceutical-development-container.pdf). 2.5.3 Placement of Documents Guidance on the placement of documents within the CTD structure for particular submission types can be found in the HYPERLINK "http://ec.europa.eu/enterprise/sectors/pharmaceuticals/documents/eudralex/vol-2/index_en.htm"EU-CTD Notice to Applicants. Correspondence In addition to the NeeS application, information may need to be exchanged to assist the processing or handling of the application. Not all such correspondence need to be included in the NeeS dossier. Accordingly, the correspondence sent via the usual electronic means (email, Eudralink etc) only needs to be in full NeeS format if it relates directly to the content of the dossier. Paper requirements Paper copies of the dossier are no longer required in most NCAs. An overview of the requirements for electronic copies with or without paper is specified for each NCA at the  HYPERLINK "http://www.hma.eu/277.html" CMDh website (eSubmissions). The  HYPERLINK "http://ec.europa.eu/enterprise/sectors/pharmaceuticals/files/eudralex/vol-2/b/ectd_01-20006/ectdpaperv1.0.pdf" Practical guidance for the paper submission of regulatory information in support of a marketing authorisation application when using the Electronic Common Technical Document (eCTD) as the source submission applies to NeeS submissions as well. Hardware NCAs will not accept any hardware (laptops, desktops, zip drives, etc.) from applicants in connection with the submission of information in electronic format. The electronic information should be directly readable and usable on NCAs hardware and software. File formats Detailed guidance on the specific file formats can be found in the ICH eCTD specification document and EU Module 1 specifications. 2.9.1 PDF In general terms the majority of documents included in electronic submissions should be in PDF format. Portable Document Format (PDF) is an open, de facto, electronic publishing standard, created by Adobe Systems Incorporated. There are several alternative suppliers of PDF software. Applicants need to check that the PDF documents meet the following key requirements: Files should be legible with Acrobat Reader, version 5.0 or higher. PDF file version 1.4 only should be used except where there is an agency specific requirement for a later version for application forms. Documents should be generated from electronic source documents and not from scanned material, except where access to the source electronic file is unavailable or where a signature is required. See  HYPERLINK \l "_1._General" Annex 1 for further guidance on text searchable documents. 2.9.2 Extensible Mark-up Language (XML) XML is the format for the backbone files for the eCTD but not in a NeeS dossier. Details on XML can be found in the  HYPERLINK "http://estri.ich.org/eCTD/eCTD_Specification_v3_2_2.pdf" ICH eCTD Specification Document, Appendix 7. Initiatives on the use of XML structured information are supported by NCAs and the EMA for the Product Information Management (PIM) system and e-application forms. Please refer to EMA eSubmission website for further details. 2.9.3 Other File Formats Other file formats such as rich text (RTF) or MS Word formats may be required in addition to the PDF requirement of the NeeS by some NCAs, especially for the provision of product information documents. Please refer to the  HYPERLINK "http://www.hma.eu/277.html" CMDh website for further details. These files should not be added within the NeeS structure. They should be provided in a separate folder called, e.g. workingdocuments on the same CD/DVD containing the NeeS.  Bookmarks and hypertext links Navigation through an electronic submission is greatly enhanced by the intelligent use of bookmarks and hypertext links. ICH guidance states It is expected that any document that has a Table of Contents (TOC) will have bookmarks (see the eCTD specification for details). Documents without TOCs should have bookmarks included where it aids in the navigation around the document content. For example, a 4 page document summarising findings could require bookmarks to aid navigation. However, a 300 page file containing a single data listing might not require bookmarks as there is no further internal structure. Please consult regional guidance documents for further details. In general terms, bookmarks and hyperlinks should be used to aid navigation. Additional details on creating bookmarks and hypertext links in PDF documents can be found in the  HYPERLINK "http://estri.ich.org/"ICH eCTD Specification, Appendix 7. Each document should be referred to from a table of content (the overall TOC or any module TOC as applicable). Technical validation of NeeS submissions The technical validation of a NeeS is a separate activity to the content validation of a submission and takes place irrespective of the type of the submission. A HYPERLINK "http://esubmission.ema.europa.eu/doc/EU%20NeeS%20validation%20Criteria%20v1.0.pdf"common set of technical criteria against which all NeeS can be checked using a validation tool are published on the EMA eSubmission website. A NeeS must pass both the technical validation and the business/content validation and errors found should be fixed by sending an updated NeeS submission. If the applicant chooses to submit their validation report from any tool (e.g. the so called Best Report) electronically, this should be put at the root level outside the NeeS structure and not be referred to in the TOC. Other Technical Information 2.12.1 Security issues The physical security of the submission during transportation is the responsibility of the applicant. Once received by NCAs, security and submission integrity is the sole responsibility of the NCA. 2.12.2 Password protection Submission or file level security is not permitted. If one-time security settings or password protection of an electronic submission is used this could constitute grounds for the rejection of the submission. However, for some documents it might be acceptable (please refer to the HYPERLINK "http://esubmission.ema.europa.eu/doc/EU%20NeeS%20validation%20Criteria%20v1.0.pdf"NeeS Validation Criteria). 2.12.3 Virus protection The applicant is responsible for checking the submission for viruses. Checking should be performed with an up-to-date virus checker and be confirmed in the cover letter. After receipt at NCAs, a similar internal virus check will be performed. If a virus is detected it will constitute grounds for rejection of the electronic submission. Electronic signatures Although electronic signatures are currently accepted in the EU as being legally equivalent to handwritten signatures (Directive 1999/93/EC), some NCAs require that certain specific documents (cover letters, Application Forms) are authenticated by separate signed paper copies. Please refer to the table for electronic submission requirements at the  HYPERLINK "http://www.hma.eu/277.html" CMDh website (eSubmissions). Transmission Media Currently CD-ROM, CD-R, DVD-R are considered acceptable media standards. Applicants should provide the electronic information on the smallest number of discs possible, taking into consideration the size of the submission. If an individual NeeS submission is of such a size as to span several CDs, the provision of a DVD is recommended. However, if the applicant is unable to provide a DVD, and the application spans multiple CDs, then, where possible, individual CTD modules should be kept together and not be split over multiple CDs. i.e. a single CD should contain all of Module 1, another all of Module 2, etc. If one CTD module is too large to fit on one CD, then the remainder should go onto another CD, but applicants should provide multiple split modules on one CD, even if this means that additional CDs are not filled to capacity. Typically, a separate CD/DVD should be provided for each NeeS submission. However, since grouping and worksharing of variations are regarded as one procedure they should always be provided on the same CD/DVD (see example below).  Also, when submitting several applications for the same medicinal product (trade name), it would be acceptable to provide them on a single CD/DVD. This should always be clearly described in the cover letter and indicated on the disc (see 2.12.6). Some NCAs have portals for upload of submissions and some submissions could also be acceptable or required to be sent by e-mail. Please refer to the  HYPERLINK "http://www.hma.eu/277.html" CMDh website (eSubmissions). Labelling of Media: Each CD or DVD submitted with a NeeS should include the following label information, clearly presented and printed on the media: Format: NeeS The applicants name The product (invented) name(s) The International Non-proprietary Name (INN) of the active substance(s) The full application number(s) (if known) Number of media units per full set and an indication of the place of the individual CD/DVD within this set (e.g. 1(5), 2(5), etc. The submission type(s) of each NeeS submission(s) contained on the CD/DVD (e.g. Initial Application, Variation Type II) Procedure for sending electronic information Some NCAs are able to accept NeeS submitted via their portals. Generally only small (<100MB) applications can be handled this way. Applicants should check with individual NCAs for details of this process. If submissions are uploaded via a portal no data corruption should occur as a result of the process. In all other cases the NeeS submission should be sent to the address referred to in the HYPERLINK "http://ec.europa.eu/enterprise/sectors/pharmaceuticals/documents/eudralex/vol-2/index_en.htm"Notice to Applicants, Volume 2A Chapter 7. Electronic media sets should be submitted at the same time as any required paper documentation. The electronic media should be packed adequately to prevent damage and the package should include a cover letter. The cover letter should include as a minimum, the information specified in the HYPERLINK "http://www.hma.eu/91.html"CMDh Guidance document and a template is published on the same webpage that could be use. Archiving and working copies Please refer to the table for electronic submission requirements at the  HYPERLINK "http://www.hma.eu/277.html" CMDh website (eSubmissions) for details of the number of copies of electronic submissions required for archiving and review purposes. Many NCAs destroy discs after data has been uploaded into their systems. Where an NCA requires the disc to be archived they may have additional requirements. Note: The current standard to burn CDs/DVDs is  HYPERLINK "http://en.wikipedia.org/wiki/Universal_Disk_Format"UDF, which has replaced the former  HYPERLINK "http://en.wikipedia.org/wiki/ISO_9660"ISO standard 9660. 3 Module specific information 3.1 Module 1.2: Administrative Information (Application Forms) The application form should always be provided as a PDF file within the NeeS structure and for some NCAs also be provided as a signed paper copy or submitted through a portal. Please refer to the  HYPERLINK "http://www.hma.eu/277.html" CMDh website (eSubmissions) for details. For this specific PDF file a newer version than PDF version 1.4 may be appropriate and acceptable in accordance with the HYPERLINK "http://esubmission.ema.europa.eu/doc/EU%20NeeS%20validation%20Criteria%20v1.0.pdf"NeeS validation criteria. Module 1.3.1: Product Information For NeeS applications product information should be supplied as PDF files within the NeeS structure but many NCAs require an RTF/Word file in addition to facilitate assessment (see also section 2.9.3). Please refer to the HYPERLINK "http://www.hma.eu/277.html"CMDh website (eSubmissions) for details. During the translation phase in MRP and DCP, it is acceptable to provide the product information documents outside the NeeS structure. The same would apply for product information in national procedures. Module 1-responses The organisation of the submission of electronic information in response to a list of questions from NCAs should follow the same basic principles as the first submission. The written response should be submitted following the EU recommended response folder and file structure. In this case the written response document should be placed in a folder named for example mydrug/0000/m1/eu/responses. Appropriate navigation in the submission should follow the same concepts as described in section 2.2.1. Annex 1. Guidance on Text Searchable Documents 1. General Applicants are requested to ensure that all submissions contain the maximum amount of text searchable content. Documents with searchable text will aid the assessor, or any other user, in searching for specific terms and also in copying and pasting information into another document, such as an assessment report. We recognize that not all documents need to be text searchable. This short document provides some guidance about what must be text searchable and the ways to ensure that files are created appropriately. Creating Text Searchable Files PDF files with searchable text can be created by all PDF tools from a source file in a text format (e.g. MS Word, SAS, MS PowerPoint, Rich Text Files, etc.). When created in this way, the file will usually be the smallest in size (measured in kilobytes or megabytes) that they can be. If the only version of a document available is in paper, then scanning to PDF and using an Optical Character Recognition (OCR) routine is the only way to create searchable text. PDF files created in this way tend to be much larger in size, for the same number of pages (from 10 to 100 times as large), and the quality of the text that is created will almost certainly not be a 100% match to the original text. It is noted that tools for checking and correcting this text tend to be somewhat cumbersome. For these reasons, applicants are recommended to use scanning/OCR only as a last resort. Applicants are reminded that the text produced by the OCR routine should be hidden behind the image of the original page so that the user can refer to the picture of the page and the text on it as final verification of the data. As a result, the applicant should ensure that, as a minimum, the text on the scanned image is legible to the user. Poor quality images should not be provided and you should note that these can only inevitably lead to poor quality OCR text. 2. Documents that must always be text searchable (i.e. the PDF should be produced wherever possible from a text source, such as MS Word, but if sourced from a scanned original then they must be OCRd.) Key administrative documents in Module 1 including, the cover letter, application form, product information documents Applicants are reminded that some NCAs regard logging in through a portal as sufficient to establish a users identity and do not require handwritten signatures on Cover Letters and Application Forms submitted this way This also covers similar documents provided in non-MAA submissions. Any document in Module 2 of the MAA (QOS, Preclinical Overview and Summaries, Clinical Overview and Summaries). This also covers similar documents provided in non-MAA submissions. The main body of text and main tables in any preclinical or clinical report required to support the main claim of the application. This also covers similar documents provided in non-MAA submissions. The main body of text in any reports, methods, analytical procedures, etc. supplied in Module 3 of the MAA This also covers similar documents provided in non-MAA submissions. The main body of text of Periodic Safety Update Reports (PSURs) The main body of text of Risk Management Plans Any English translation of a document originally written in a foreign language (see also below) 3. Documents that do not need to be text searchable (i.e. the PDF should be produced wherever possible from a text source, such as MS Word, but if sourced from a scanned original then there is no need for OCR.) Any original GMP certificate Any original certificate of analysis Any manufacturers licences Any certificates of suitability Any Manufacturing Authorisation Any document written in a foreign language where a translation is provided in English (however, the translation should be text searchable, see above) Any literature references sourced from journals, periodicals and books (except when these are used in a bibliographic application to support the main claims of the application). The blank CRF in a Clinical Study Report Patient data listings (when supplied) CRFs (when supplied) Any page with a signature that does not contain other information key to the understanding of the submission Applicants should consider providing signatures on separate pages from key text in reports, overviews, etc. 4. Further Information If applicants are uncertain whether or not a particular document should be text searchable, they should contact their NCA for guidance. Annex 2. Example Tables of Contents These Tables of Contents are examples and are provided for illustrative and guidance purposes only. The blue underlined text illustrates where hyperlinks to the individual documents may be added. In these examples there are some Not applicable documents shown. Not applicable documents should not appear in the dossier and nor should they be included in the TOCs. The following is an example of a CTD TOC (main TOC) Module 1Administrative Information and Prescribing InformationModule 1Module 2Common Technical Document SummariesModule 2Module 3QualityModule 3Module 4Nonclinical Study ReportsModule 4Module 5Clinical Study ReportsModule 5 The following are examples of module TOCs. Module 1Administrative Information and Prescribing Information1.0Cover Letter1.01.2Application form 1.2Annex 5.3 Proof of establishment of the applicant in the EEA.Annex 5.3Annex 5.4 Letter of authorisation for communication on behalf of the applicant/MAHAnnex 5.4Annex 5.5 Curriculum Vitae of the Qualified Person for PharmacovigilanceAnnex 5.5Annex 5.6 Manufacturing Authorisation required under Article 40 of Directive 2001/83/ECAnnex 5.6Annex 5.8 Flow-chart indicating all sites involved in the manufacturing process of the medicinal product or active substanceAnnex 5.8Annex 5.9 GMP certificate(s) or other GMP statement(s); Where applicable a summary of other GMP inspections performed. Annex 5.9Annex 5.12 Ph. Eur. Certificate(s) of suitability for TSEAnnex 5.12Annex 5.17 List of Mock-ups or Samples/specimens sent with the application, as appropriate Annex 5.17Annex 5.22 declaration from the Qualified Person of the manufacturing authorisation holderAnnex 5.221.3.Product information1.3.1.3.1SPC, Labelling and Package Leaflet1.3.1common - combined SPC1.3.1be - de - immediate packaging 10 mg1.3.1be - de - intermediate packaging 10 mg1.3.1be - de - outer packaging 10 mg1.3.1be - de - package leaflet 10 mg1.3.1be - fr - immediate packaging 10 mg1.3.1be - fr - intermediate packaging 10 mg1.3.1be - fr - outer packaging 10 mg1.3.1be - fr - package leaflet 10 mg1.3.1be - fr - combined SPC1.3.1be - nl - immediate packaging 10 mg1.3.1be - nl - intermediate packaging 10 mg1.3.1be - nl - outer packaging 10 mg1.3.1be - nl - package leaflet 10 mg1.3.1be - nl - combined SPC1.3.11.3.2Mock-up1.3.2common - immediate packaging 10 mg1.3.2common - intermediate packaging 10 mg1.3.2common - outer packaging 10 mg1.3.2common - package leaflet 10 mg1.3.2be - immediate packaging 10 mg1.3.2be - intermediate packaging 10 mg1.3.2be - outer packaging 10 mg1.3.2be - package leaflet 10 mg1.3.21.3.3Specimen1.3.3common-specimen1.3.3be - specimen1.3.31.3.4Consultation with target patient groups1.3.4common - consultation with target patient groups1.3.4be - consultation with target patient groups1.3.41.3.5Product Information already approved in the Member States1.3.5common - approved package leaflet 10 mg1.3.5common - approved combined SPC1.3.5be - approved package leaflet 10 mg1.3.5be - approved combined SPC1.3.51.3.6Braille1.3.61.4Information about Experts1.41.4.1Quality1.4.11.4.2Non-Clinical1.4.21.4.3Clinical1.4.31.5Specific Requirements for Different Types of Application1.51.5.1Information about bibliographical applications1.5.11.5.2Information for Generic, `Hybrid` or Bio-similar ApplicationsNot Applicable1.5.3(Extended) Data/Market ExclusivityNot Applicable1.5.4Exceptional CircumstancesNot Applicable1.5.5Conditional Marketing AuthorisationNot Applicable1.6Environmental Risk Assessment1.61.6.1Non-GMO1.6.11.6.2GMONot Applicable1.7Information on Orphan Market Exclusivity1.71.7.1Similarity1.7.11.7.2Market ExclusivityNot Applicable1.8Information on Pharmacovigilance1.81.8.1Pharmacovigilance System 1.8.11.8.2Risk-management System1.8.21.9Information Relating to Clinical Trials1.91.10Information Relating to Paediatrics1.10Responses to Questions Not ApplicableAdditional DataNot Applicable Module 2Common Technical Document Summaries2.2Introduction2.22.3.SDrug Substance - Eurotriptan Maleate - EuroFactory2.3.S2.3.S.1 General Information2.3.S.1 2.3.S.2 Manufacture2.3.S.2 2.3.S.3 Characterisation2.3.S.3 2.3.S.4 Control of Drug Substance2.3.S.4 2.3.S.5 Reference Standards or Materials2.3.S.5 2.3.S.6 Container Closure System2.3.S.6 2.3.S.7 Stability2.3.S.7 2.3.SDrug Substance - Eurogreen GreenFactory2.3.S2.3.S.1General Information2.3.S.1 2.3.S.2 Manufacture2.3.S.2 2.3.S.3 Characterisation2.3.S.3 2.3.S.4 Control of Drug Substance2.3.S.4 2.3.S.5 Reference Standards or Materials2.3.S.5 2.3.S.6 Container Closure System2.3.S.6 2.3.S.7 Stability2.3.S.7 2.3.PDrug Product - Efpiate capsule - Small Factory2.3.P 2.3.P.1 Description and Composition of the Drug Product2.3.P.1 2.3.P.2 Pharmaceutical Development2.3.P.2 2.3.P.3 Manufacture2.3.P.3 2.3.P.4Control of Excipients2.3.P.42.3.P.5 Control of Drug Product2.3.P.5 2.3.P.6 Reference Standards or Materials2.3.P.6 2.3.P.7 Container Closure System2.3.P.7 2.3.P.8 Stability2.3.P.8 2.3.AAppendices2.3.A2.3.A.1Facilities and Equipment2.3.A.12.3.A.2Adventitious Agents Safety Evaluation - Eurogreen - GreenFactory2.3.A.22.3.A.2Adventitious Agents Safety Evaluation - Eurotriptan Maleate - EuroFactory2.3.A.22.3.A.3Novel Excipients2.3.A.32.3.R Regional Information2.3.R 2.4Nonclinical Overview 2.42.5Clinical Overview 2.52.6 Nonclinical Written and Tabulated Summary2.6 2.6.1 Introduction2.6.1 2.6.2 Pharmacology Written Summary2.6.2 2.6.3 Pharmacology Tabulated Summary2.6.3 2.6.4 Pharmacokinetics Written Summary2.6.4 2.6.5 Pharmacokinetics Tabulated Summary2.6.5 2.6.6 Toxicology Written Summary2.6.6 2.6.7 Toxicology Tabulated Summary2.6.7 2.7 Clinical Summary2.7 2.7.1 Summary of Biopharmaceutic Studies and Associated Analytical Methods2.7.1 2.7.2 Summary of Clinical Pharmacology Studies2.7.2 2.7.3 Summary of Clinical Efficacy2.7.3 2.7.4 Summary of Clinical Safety2.7.4 2.7.5 Literature References2.7.5 2.7.6 Synopses of Individual Studies2.7.6  Module 3Quality3.2Body of Data 3.23.2.SDrug Substance (eurogreen-greenfact)3.2.S3.2.S.1General Information (eurogreen-greenfact)3.2.S.13.2.S.1.1Nomenclature (eurogreen-greenfact)3.2.S.1.13.2.S.1.2Structure (eurogreen-greenfact)3.2.S.1.23.2.S.1.3General Properties (eurogreen-greenfact)3.2.S.1.33.2.S.2Manufacture (eurogreen-greenfact)3.2.S.23.2.S.2.1Manufacturer(s) (eurogreen-greenfact)3.2.S.2.13.2.S.2.2Description of Manufacturing Process and Process Controls (eurogreen-greenfact)3.2.S.2.23.2.S.2.3Control of Materials (eurogreen-greenfact)3.2.S.2.33.2.S.2.4Control of Critical Steps and Intermediates (eurogreen-greenfact)3.2.S.2.43.2.S.2.5Process Validation and/or Evaluation (eurogreen-greenfact)3.2.S.2.53.2.S.2.6Manufacturing Process Development (eurogreen-greenfact)3.2.S.2.63.2.S.3Characterisation (eurogreen-greenfact)3.2.S.33.2.S.3.1Elucidation of Structure and Other Characteristics (eurogreen-greenfact)3.2.S.3.13.2.S.3.2Impurities (eurogreen-greenfact)3.2.S.3.23.2.S.4Control of Drug Substance (eurogreen-greenfact)3.2.S.43.2.S.4.1Specification (eurogreen-greenfact)3.2.S.4.13.2.S.4.2Analytical Procedures (eurogreen-greenfact)3.2.S.4.23.2.S.4.3Validation of Analytical Procedures (eurogreen-greenfact)3.2.S.4.33.2.S.4.4Batch Analyses (eurogreen-greenfact)3.2.S.4.43.2.S.4.5Justification of Specification (eurogreen-greenfact)3.2.S.4.53.2.S.5Reference Standards or Materials (eurogreen-greenfact)3.2.S.53.2.S.6Container Closure System (eurogreen-greenfact)3.2.S.63.2.S.7Stability (eurogreen-greenfact)3.2.S.73.2.S.7.1Stability Summary and Conclusions (eurogreen-greenfact)3.2.S.7.13.2.S.7.2Post-approval Stability Protocol and Stability Commitment (eurogreen-greenfact)3.2.S.7.23.2.S.7.3Stability Data (eurogreen-greenfact)3.2.S.7.33.2.SDrug Substance (eurotriptan-maleate-eurofact)3.2.S3.2.S.1General Information (eurotriptan-maleate-eurofact)3.2.S.13.2.S.1.1Nomenclature (eurotriptan-maleate-eurofact)3.2.S.1.13.2.S.1.2Structure (eurotriptan-maleate-eurofact)3.2.S.1.23.2.S.1.3General Properties (eurotriptan-maleate-eurofact)3.2.S.1.33.2.S.2Manufacture (eurotriptan-maleate-eurofact)3.2.S.23.2.S.2.1Manufacturer(s) (eurotriptan-maleate-eurofact)3.2.S.2.13.2.S.2.2Description of Manufacturing Process and Process Controls (eurotriptan-maleate-eurofact)3.2.S.2.23.2.S.2.3Control of Materials (eurotriptan-maleate-eurofact)3.2.S.2.33.2.S.2.4Control of Critical Steps and Intermediates (eurotriptan-maleate-eurofact)3.2.S.2.43.2.S.2.5Process Validation and/or Evaluation (eurotriptan-maleate-eurofact)3.2.S.2.53.2.S.2.6Manufacturing Process Development (eurotriptan-maleate-eurofact)3.2.S.2.63.2.S.3Characterisation (eurotriptan-maleate-eurofact)3.2.S.33.2.S.3.1Elucidation of Structure and Other Characteristics (eurotriptan-maleate-eurofact)3.2.S.3.13.2.S.3.2Impurities (eurotriptan-maleate-eurofact)3.2.S.3.23.2.S.4Control of Drug Substance (eurotriptan-maleate-eurofact)3.2.S.43.2.S.4.1Specification (eurotriptan-maleate-eurofact)3.2.S.4.13.2.S.4.2Analytical Procedures (eurotriptan-maleate-eurofact)3.2.S.4.23.2.S.4.3Validation of Analytical Procedures (eurotriptan-maleate-eurofact)3.2.S.4.33.2.S.4.4Batch Analyses (eurotriptan-maleate-eurofact)3.2.S.4.43.2.S.4.5Justification of Specification (eurotriptan-maleate-eurofact)3.2.S.4.53.2.S.5Reference Standards or Materials (eurotriptan-maleate-eurofact)3.2.S.53.2.S.6Container Closure System (eurotriptan-maleate-eurofact)3.2.S.63.2.S.7Stability (eurotriptan-maleate-eurofact)3.2.S.73.2.S.7.1Stability Summary and Conclusions (eurotriptan-maleate-eurofact)3.2.S.7.13.2.S.7.2Post-approval Stability Protocol and Stability Commitment (eurotriptan-maleate-eurofact)3.2.S.7.23.2.S.7.3Stability Data (eurotriptan-maleate-eurofact)3.2.S.7.33.2.PDrug Product3.2.P3.2.P.1Description and Composition of the Drug Product 3.2.P.13.2.P.2Pharmaceutical Development3.2.P.23.2.P.2.1Components of the Drug Product 3.2.P.2.13.2.P.2.2Drug Product3.2.P.2.23.2.P.2.3Manufacturing Process Development3.2.P.2.33.2.P.2.4Container Closure System3.2.P.2.43.2.P.2.5Microbiological Attributes3.2.P.2.53.2.P.2.6Compatibility3.2.P.2.63.2.P.3Manufacture 3.2.P.33.2.P.3.1Manufacturer(s) 3.2.P.3.13.2.P.3.2Batch Formula3.2.P.3.23.2.P.3.3Description of Manufacturing Process and Process Controls3.2.P.3.33.2.P.3.4Controls of Critical Steps and Intermediates3.2.P.3.43.2.P.3.5Process Validation and/or Evaluation3.2.P.3.53.2.P.4Control of Excipient - compendial3.2.P.43.2.P.4.1Specifications 3.2.P.4.13.2.P.4.2Analytical ProceduresNot Applicable3.2.P.4.3Validation of Analytical ProceduresNot Applicable3.2.P.4.4Justification of SpecificationsNot Applicable3.2.P.4.5Excipients of Human or Animal Origin3.2.P.4.53.2.P.4.6Novel Excipients3.2.P.4.63.2.P.4Control of Excipient - non-compendial excipient 13.2.P.43.2.P.4.1Specifications 3.2.P.4.13.2.P.4.2Analytical Procedures3.2.P.4.23.2.P.4.3Validation of Analytical Procedures3.2.P.4.33.2.P.4.4Justification of Specifications3.2.P.4.43.2.P.4.5Excipients of Human or Animal Origin3.2.P.4.53.2.P.4.6Novel Excipients3.2.P.4.63.2.P.5Control of Drug Product3.2.P.53.2.P.5.1Specifications 3.2.P.5.13.2.P.5.2Analytical Procedures3.2.P.5.23.2.P.5.3 Validation of Analytical Procedures3.2.P.5.3 3.2.P.5.4Batch Analyses3.2.P.5.43.2.P.5.5Characterisation of Impurities3.2.P.5.53.2.P.5.6Justification of Specification(s)3.2.P.5.63.2.P.6Reference Standards or Materials 3.2.P.63.2.P.7Container Closure System3.2.P.73.2.P.8Stability3.2.P.83.2.P.8.1Stability Summary and Conclusions 3.2.P.8.13.2.P.8.2Post-approval Stability Protocol and Stability Commitment3.2.P.8.23.2.P.8.3Stability Data3.2.P.8.33.2.RRegional Information3.2.R3.2.A Appendices3.2.A3.2.A.1Facilities and Equipment - eurofact3.2.A.13.2.A.1Facilities and Equipment - greenfact3.2.A.13.2.A.1Facilities and Equipment - small factory3.2.A.13.2.A.2Adventitious Agents Safety Evaluation - eurofact3.2.A.23.2.A.2Adventitious Agents Safety Evaluation - greenfact3.2.A.23.2.A.3Novel Excipients3.2.A.33.3Literature References3.33.3Reference 13.33.3Reference 23.33.3Reference 33.3 Module 4Nonclinical Study Reports4.2Study Reports 4.24.2.1Pharmacology4.2.14.2.1.1Primary Pharmacodynamics4.2.1.1study report 14.2.1.1study report 24.2.1.1study report 34.2.1.14.2.1.2Secondary Pharmacodynamics4.2.1.2study report 14.2.1.2study report 24.2.1.2study report 34.2.1.24.2.1.3Safety Pharmacology4.2.1.3study report 14.2.1.3study report 24.2.1.3study report 34.2.1.34.2.1.4Pharmacodynamic Drug Interaction4.2.1.4study report 14.2.1.4study report 24.2.1.4study report 34.2.1.44.2.2Pharmacokinetics4.2.24.2.2.1Analytical Methods and Validation Reports4.2.2.1study report 14.2.2.1study report 24.2.2.1study report 34.2.2.14.2.2.2Absorption4.2.2.2study report 14.2.2.2study report 24.2.2.2study report 34.2.2.24.2.2.3Distribution4.2.2.3study report 14.2.2.3study report 24.2.2.3study report 34.2.2.34.2.2.4Metabolism4.2.2.4study report 14.2.2.4study report 24.2.2.4study report 34.2.2.44.2.2.5Excretion4.2.2.5study report 14.2.2.5study report 24.2.2.5study report 34.2.2.54.2.2.6Pharmacokinetic D Other Pharmacokinetic Studies rug Interactions (nonclinical)4.2.2.6study report 14.2.2.6study report 24.2.2.6study report 34.2.2.64.2.2.7Other Pharmacokinetic Studies4.2.2.7study report 14.2.2.7study report 24.2.2.7study report 34.2.2.74.2.3Toxicology4.2.34.2.3.1Single-Dose Toxicity4.2.3.1study report 14.2.3.1study report 24.2.3.1study report 34.2.3.14.2.3.2Repeat-Dose Toxicity4.2.3.2study report 14.2.3.2study report 24.2.3.2study report 34.2.3.24.2.3.3Genotoxicity4.2.3.34.2.3.3.1In Vitro4.2.3.3.1study report 14.2.3.3.14.2.3.3.2In Vivo4.2.3.3.2study report 14.2.3.3.2study report 24.2.3.3.24.2.3.4Carcinogenicity4.2.3.44.2.3.4.1Long-term studies4.2.3.4.1study report 14.2.3.4.14.2.3.4.2Short- or medium term studies4.2.3.4.2study report 14.2.3.4.2study report 24.2.3.4.24.2.3.4.3Other studies4.2.3.4.3study report 14.2.3.4.3study report 24.2.3.4.34.2.3.4.3study report 34.2.3.4.34.2.3.5Reproductive and Developmental Toxicity4.2.3.54.2.3.5.1Fertility and early embryonic development4.2.3.5.1study report 14.2.3.5.14.2.3.5.2Embryo-fetal development4.2.3.5.2study report 14.2.3.5.2study report 24.2.3.5.24.2.3.5.3Prenatal and postnatal development, including maternal function4.2.3.5.3study report 14.2.3.5.3study report 24.2.3.5.3study report 34.2.3.5.34.2.3.5.4Studies in which the offspring (juvenile animals) are dosed and/or further evaluated4.2.3.5.4study report 14.2.3.5.44.2.3.6Local Tolerance4.2.3.6study report 14.2.3.64.2.3.7Other Toxicity Studies4.2.3.74.2.3.7.1Antigenicity4.2.3.7.1study report 14.2.3.7.1study report 24.2.3.7.14.2.3.7.2Immunotoxicity4.2.3.7.2study report 14.2.3.7.24.2.3.7.3Mechanistic studies4.2.3.7.3study report 14.2.3.7.34.2.3.7.4Dependence4.2.3.7.4study report 14.2.3.7.4study report 24.2.3.7.44.2.3.7.5Metabolites4.2.3.7.5study report 14.2.3.7.5study report 24.2.3.7.5study report 34.2.3.7.54.2.3.7.6Impurities4.2.3.7.6study report 14.2.3.7.64.2.3.7.7Other4.2.3.7.7study report 14.2.3.7.74.3Literature References4.3Reference 14.3Reference 24.3Reference 34.3 Module 5Clinical Study Reports5.2Tabular Listing of All Clinical Studies5.25.3Clinical Study Reports5.35.3.1Reports of Biopharmaceutic Studies5.3.15.3.1.1Bioavailability (BA) Study Reports5.3.1.1study report 15.3.1.1study report 25.3.1.1study report 35.3.1.15.3.1.2Comparative BA and Bioequivalence (BE) Study Reports5.3.1.2study report 15.3.1.2study report 25.3.1.25.3.1.3In Vitro-In Vivo Correlation Study Reports5.3.1.3study 51002 - title page5.3.1.3study 51002 - synopsis5.3.1.3study 51002 - body5.3.1.3study 51002 - appendix-16-1-15.3.1.3study 51002 - appendix-16-1-25.3.1.3study 51002 - appendix-16-1-35.3.1.3study 51002 - appendix-16-1-45.3.1.3study 51002 - appendix-16-1-55.3.1.3study 51002 - appendix-16-1-75.3.1.3study 51002 - appendix-16-1-85.3.1.3study 51002 - appendix-16-1-95.3.1.3study 51002 - appendix-16-1-105.3.1.3study 51002 - appendix-16-1-115.3.1.3study 51002 - appendix-16-1-125.3.1.3study 51002 - appendix-16-2-25.3.1.3study 51002 - appendix-16-2-75.3.1.3study 51002 - appendix-16-3-15.3.1.3study 51002 - appendix-16-3-25.3.1.35.3.1.4Reports of Bioanalytical and Analytical Methods for Human Studies5.3.1.4study 51003 - title-page.pdf5.3.1.4study 51003 - synopsis.pdf5.3.1.4study 51003 - body5.3.1.4study 51003 - appendix-16-1-1.pdf5.3.1.4study 51003 - appendix-16-1-2.pdf5.3.1.4study 51003 - appendix-16-1-3.pdf5.3.1.4study 51003 - appendix-16-1-4.pdf5.3.1.4study 51003 - appendix-16-1-5.pdf5.3.1.4study 51003 - appendix-16-1-7.pdf5.3.1.4study 51003 - appendix-16-1-8.pdf5.3.1.4study 51003 - appendix-16-1-9.pdf5.3.1.4study 51003 - appendix-16-1-10.pdf5.3.1.4study 51003 - appendix-16-1-11.pdf5.3.1.4study 51003 - appendix-16-1-12.pdf5.3.1.4study 51003 - appendix-16-2-2.pdf5.3.1.4study 51003 - appendix-16-2-7.pdf5.3.1.4study 51003 - appendix-16-3-1.pdf5.3.1.4study 51003 - appendix-16-3-2.pdf5.3.1.45.3.2Reports of Studies Pertinent to PK using Human Biomaterials 5.3.25.3.2.1Plasma Protein Binding Study Reports5.3.2.1study report 15.3.2.15.3.2.2Reports of Hepatic Metabolism and Drug Interaction Studies5.3.2.2study report 15.3.2.25.3.2.3Reports of Studies Using Other Human Biomaterials5.3.2.3 study report 510065.3.2.3 5.3.3Reports of Human PK Studies 5.3.35.3.3.1Healthy Subject PK and Initial Tolerability Study Reports 5.3.3.1study report 15.3.3.1study report 25.3.3.15.3.3.2Patient PK and Initial Tolerability Study Reports5.3.3.2study report 15.3.3.25.3.3.3Intrinsic Factor PK Study Reports5.3.3.3study report 15.3.3.35.3.3.4Extrinsic Factor PK Study Reports5.3.3.4study report 15.3.3.45.3.3.5Population PK Study Reports5.3.3.5study report 15.3.3.55.3.4Reports of Human PD Studies 5.3.45.3.4.1Healthy Subject PD and PK/PD Study Reports5.3.4.1study report 15.3.4.15.3.4.2Patient PD and PK/PD Study Reports5.3.4.2study report 15.3.4.2study report 25.3.4.25.3.5Reports of Efficacy and Safety Studies (confusion)5.3.55.3.5.1Study Reports of Controlled Clinical Studies Pertinent to the Claimed Indication5.3.5.1study ab12345 - synopsis5.3.5.1study ab12345 - report body5.3.5.1study ab12345 - protocol5.3.5.1study ab12345 - protocol amendment a5.3.5.1study ab12345 - randomisation code5.3.5.1study ab12345 - adverse events listings5.3.5.1study ab12345 - blank CRF5.3.5.1study ab12345 - demographic table5.3.5.1study ab12345 - Ethics Committee Approval5.3.5.1study cd98765 - synopsis5.3.5.1study cd98765 - report body5.3.5.1study cd98765 - protocol5.3.5.1study cd98765 - randomisation code5.3.5.1study cd98765 - adverse events listings5.3.5.1study cd98765 - blank CRF5.3.5.1study cd98765 - demographic table5.3.5.1study cd98765 - Ethics Committee Approval5.3.5.15.3.5.2Study Reports of Uncontrolled Clinical Studies5.3.5.2study report 510155.3.5.25.3.5.3Reports of Analyses of Data From More Than One Study5.3.5.3study report 510165.3.5.35.3.5.4Other Clinical Study Reports5.3.5.4study report 510175.3.5.45.3.6Post-marketing ExperienceNot Applicable5.3.7Case Report Forms and Individual Patient Listings when submitted5.3.7study ab12345 - appendix 16-3-15.3.7study ab12345 - appendix 16-3-25.3.7study ab12345 - appendix 16-45.3.7study cde98765 - appendix 16-3-15.3.7study cde98765 - appendix 16-3-25.3.7study cde98765 - appendix 16-45.3.7study 51002 - appendix 16-3-15.3.7study 51002 - appendix 16-3-25.3.7study 51002 - appendix 16-45.3.7study 51003 - appendix 16-3-15.3.7study 51003 - appendix 16-3-25.3.7study 510023- appendix 16-45.3.75.4Literature References 5.4 reference 15.4 reference 25.4 reference 35.4  Document Control Change Record VersionAuthor(s)CommentsJune 2007 June 2007 August 2007 1.1 October 2007 1.2 November 2007 1.3 December 2007 1.4 January 2008 1.41 December 2009 1.42 December 2009 1.43 December 2009 1.44 January 2010 1.45 January 2010 1.46 February 2010 1.47 February 2010 1.48 March 2010 1.49 March 2010Ricco van den Hoorn Alison Davis David Wheeler David Wheeler David Wheeler David Wheeler David Wheeler Karin Grndahl Karin Grndahl Karin Grndahl Klaus Menges Karin Grndahl Karin Grndahl/ Geoff Williams Karin Grndahl Karin Grndahl Karin Grndahl With suggested changes from BfARM accepted Following comments from Topic Group Members, removal of references to eCTD Following comments at Topic Group meeting 29 August Following comments at Topic Group meeting 16/17 October Following review comments at TIGes et al Following review/comments at Topic Group 19 December New draft version for comments; updated in accordance with the eCTD guidance and CRs received to MHRA New draft version after subgroup TC meeting 9 December New draft version after subgroup TC meeting 22 December Commented draft 1.43 for subgroup TC meeting 14 January New draft version after subgroup TC meeting 14 January New draft version after subgroup TC meeting 12 February Minor changed new version after e-mails within the subgroup Final draft version after subgroup meeting at EMA 2 March Final version after TIGes meeting at EMA 3 March Reviewers VersionNameOrganisation1.41 1.46Members of the SubgroupTIGes Harmonisation Subgroup1.47Members of the SubgroupTIGes Harmonisation Subgroup1.48Members of TIGesTIGes1.49Members of the SubgroupTIGes Harmonisation Subgroup Distribution VersionDistributed toWay of distribution1.41 1.46Members of the SubgroupE-mail in1.47Members of TIGesE-mail 26 February1.48Members of TIGesE-mail 2 March and presented at the meeting1.49Members of the SubgroupE-mail 18 March. To be published as 2.0. Coming into Operation VersionDate in operationComment1.4January 2008Draft for publication to use2.0March 2009Final version for publication     PAGE 21 PAGE 21 Guidance for Industry on Providing Regulatory Information in Electronic Format: NeeS Version: 2.0, March 2010  PAGE 2  EMBED PowerPoint.Slide.8   Z[deoz}   % & ' ) / 0 8 ; 𶬶~rdYhQ}5CJmH sH hXphl5CJmH sH h>h5CJaJhl h9hlh4}hl5h4}hl5aJ hB,5aJhhx5aJhh-e5aJhh4}5aJ hGoa5CJ$ h-5CJ$ hr[5CJ$ h5CJ$ hJ5CJ$ hl5CJ$ hCJ hlCJh*5CJ aJ "  Z[& ' $a$$a$gd' ( ) * + , - . / 0 < G H Q  `  `  m "  ! gd#:=$a$gd/$a$$a$; < A B F G H I J P Q R i j k l ̿zvzfzaWaJWE h@7j}hc.Ujhc.U hc.jhm|$hc.0JUhc.hm|$hc.0Jjhm|$hc.0JUhbjhbUhXphCmH sH hXphlmH sH hXphlCJmH sH hXph/CJmH sH hXphl5CJhXphU5CJhXphB55CJ hB55CJhXphl5CJmH sH         # $ }rcrQcFc}h@7mHnHu#jwhc.UmHnHujhc.UmHnHuhc.mHnHu,hc.5CJOJQJaJmHnHsHtHu*jhm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu$jhm|$hc.0JUmHnHu)hc.5CJOJQJaJmHnHsHtHjhm|$hc.0JUjhc.U$ % & ' ( > ? @ Z [ \ ] ^ _ ` a b ~  ɲɧ{ײr\Gɧ)hc.CJOJQJaJmHnHsHtHu*jhm|$hc.0JUmHnHuhc.mHnHuh@7mHnHu#jqhc.UmHnHujhc.UmHnHuhc.mHnHu,hc.5CJOJQJaJmHnHsHtHuhm|$hc.0JmHnHu$jhm|$hc.0JUmHnHu*jhm|$hc.0JUmHnHu        & ' ( ~ssaK*jhm|$hc.0JUmHnHu#jehc.UmHnHuhc.mHnHu*jhm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu)hc.CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHuh@7mHnHujhc.UmHnHu#jkhc.UmHnHu( ) . / > ? @ Z [ \ ] ^ _ ` a b ~  ߿ߊt߿bߊ#jYhc.UmHnHu*jhm|$hc.0JUmHnHuhc.mHnHuh@7mHnHu#j_hc.UmHnHujhc.UmHnHuhc.mHnHu)hc.CJOJQJaJmHnHsHtHuhm|$hc.0JmHnHu$jhm|$hc.0JUmHnHu#     , - . / 2 3 K L M g h i j ɴɩ}״t^ɴɩL}#jMhc.UmHnHu*jhm|$hc.0JUmHnHuhc.mHnHuh@7mHnHu#jShc.UmHnHujhc.UmHnHuhc.mHnHu)hc.CJOJQJaJmHnHsHtHuhm|$hc.0JmHnHu$jhm|$hc.0JUmHnHu*jhm|$hc.0JUmHnHuj k l m n o ݺ݋ȺncݺMݺȺ*j hm|$hc.0JUmHnHuh@7mHnHu#jG hc.UmHnHuhc.mHnHuhm|$hc.0JmHnHsH u*jhm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu)hc.CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHujhc.UmHnHu       ! " # $ @ A B C F G i j k 涡tb涡#j; hc.UmHnHu*j hm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu)hc.CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHuh@7mHnHu#jA hc.UmHnHujhc.UmHnHuhc.mHnHu 345OPQRɴɩ}״t^ɴɩL}#j/ hc.UmHnHu*j hm|$hc.0JUmHnHuhc.mHnHuh@7mHnHu#j5 hc.UmHnHujhc.UmHnHuhc.mHnHu)hc.CJOJQJaJmHnHsHtHuhm|$hc.0JmHnHu$jhm|$hc.0JUmHnHu*j hm|$hc.0JUmHnHu U]Xi>Wl?G ! RSTUVWstuv{|ݺݺȺ~sݺ]ݺȺ*jhm|$hc.0JUmHnHuh@7mHnHu#j)hc.UmHnHuhc.mHnHu*j hm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu)hc.CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHujhc.UmHnHu!  &'(),-;<=WXYZ[\]^_{|}~ssaK*jhm|$hc.0JUmHnHu#jhc.UmHnHuhc.mHnHu*jhm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu)hc.CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHuh@7mHnHujhc.UmHnHu#j#hc.UmHnHu}~#$߿ߊt߿bߊ#jhc.UmHnHu*jhm|$hc.0JUmHnHuhc.mHnHuh@7mHnHu#jhc.UmHnHujhc.UmHnHuhc.mHnHu)hc.CJOJQJaJmHnHsHtHuhm|$hc.0JmHnHu$jhm|$hc.0JUmHnHu#$%&)*678RSTUVWXYZvwxy~ɴɩ}״t^ɴɩL}#jhc.UmHnHu*jhm|$hc.0JUmHnHuhc.mHnHuh@7mHnHu#j hc.UmHnHujhc.UmHnHuhc.mHnHu)hc.CJOJQJaJmHnHsHtHuhm|$hc.0JmHnHu$jhm|$hc.0JUmHnHu*jhm|$hc.0JUmHnHu     ,-./45GHIcݺݺȺ~sݺ]ݺȺ*j|hm|$hc.0JUmHnHuh@7mHnHu#jhc.UmHnHuhc.mHnHu*jhm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu)hc.CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHujhc.UmHnHu!cdefghijk~ssaK*jphm|$hc.0JUmHnHu#jhc.UmHnHuhc.mHnHu*jvhm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu)hc.CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHuh@7mHnHujhc.UmHnHu#jhc.UmHnHu89:;<=>?@\]^_cd߿ߊt߿bߊ#jhc.UmHnHu*jjhm|$hc.0JUmHnHuhc.mHnHuh@7mHnHu#jhc.UmHnHujhc.UmHnHuhc.mHnHu)hc.CJOJQJaJmHnHsHtHuhm|$hc.0JmHnHu$jhm|$hc.0JUmHnHu#!"567Qɴɩ}״t^NNhm|$hc.0JmHnHsH u*j^hm|$hc.0JUmHnHuhc.mHnHuh@7mHnHu#jhc.UmHnHujhc.UmHnHuhc.mHnHu)hc.CJOJQJaJmHnHsHtHuhm|$hc.0JmHnHu$jhm|$hc.0JUmHnHu*jdhm|$hc.0JUmHnHuQRSTUVWXYuvwx~~nnccQ#jhc.UmHnHuhc.mHnHuhm|$hc.0JmHnHsH u*jXhm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu)hc.CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHuh@7mHnHujhc.UmHnHu#jhc.UmHnHu    ./0178JKLfghiɴɩ}״t^ɴɩL}#jhc.UmHnHu*jLhm|$hc.0JUmHnHuhc.mHnHuh@7mHnHu#jhc.UmHnHujhc.UmHnHuhc.mHnHu)hc.CJOJQJaJmHnHsHtHuhm|$hc.0JmHnHu$jhm|$hc.0JUmHnHu*jRhm|$hc.0JUmHnHuijklmn9ݺݺȺ~sݺ]ݺȺ*j@hm|$hc.0JUmHnHuh@7mHnHu#jhc.UmHnHuhc.mHnHu*jFhm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu)hc.CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHujhc.UmHnHu!9:;<=>?@A]^_`fg~ssaK*j4!hm|$hc.0JUmHnHu#j hc.UmHnHuhc.mHnHu*j: hm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu)hc.CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHuh@7mHnHujhc.UmHnHu#jhc.UmHnHu#$%&)*def߽߈r]߽K#j"hc.UmHnHu)hc.CJOJQJaJmHnHsHtHu*j."hm|$hc.0JUmHnHuhc.mHnHuh@7mHnHu#j!hc.UmHnHujhc.UmHnHuhc.mHnHu,hc.5CJOJQJaJmHnHsHtHuhm|$hc.0JmHnHu$jhm|$hc.0JUmHnHu  %&'Aʫʠt^ʠ*j"$hm|$hc.0JUmHnHuh@7mHnHu#j#hc.UmHnHujhc.UmHnHuhc.mHnHu*j(#hm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu)hc.CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHu ABCDEFGHIefghrmcmVcQc<)hc.5CJOJQJaJmHnHsHtH h@7j%hc.Ujhc.U hc.hm|$hc.0JmHnHsH j%hm|$hc.0JUhc.hm|$hc.0Jjhm|$hc.0JU)hc.CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHuh@7mHnHujhc.UmHnHu#j$hc.UmHnHu %&'(+,JKҿ񝎝|q[F)hc.CJOJQJaJmHnHsHtHu*j'hm|$hc.0JUmHnHuh@7mHnHu#j&hc.UmHnHujhc.UmHnHuhc.mHnHu,hc.5CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHu*j&hm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHuKLfghjklmno𵠵scLc:#j(hc.UmHnHu,hc.5CJOJQJaJmHnHsHtHuhm|$hc.0JmHnHsH u*j (hm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu)hc.CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHuh@7mHnHu#j'hc.UmHnHuhc.mHnHujhc.UmHnHumXeI56$ & F 9r a$gd? $ 9r a$gd gdCgdI&gdV#( !  ! 567QRSUVWXYZvwxy{ӼӮttbӼӮLӮ*j)hm|$hc.0JUmHnHu#j)hc.UmHnHuhc.mHnHuhm|$hc.0JmHnHsH u*j)hm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu,hc.5CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHujhc.UmHnHuh@7mHnHu{|Я{w{g{bXbKXFX h@7ju+hc.Ujhc.U hc.j*hm|$hc.0JUhc.hm|$hc.0Jjhm|$hc.0JU$jhm|$hc.0JUmHnHuh@7mHnHu#j{*hc.UmHnHujhc.UmHnHuhc.mHnHuhm|$hc.0JmHnHu,hc.5CJOJQJaJmHnHsHtHu789:BCD^_`bcdefgɪɟ~s\Fɟ*j,hm|$hc.0JUmHnHu,hc.5CJOJQJaJmHnHsHtHuh@7mHnHu#jo,hc.UmHnHujhc.UmHnHuhc.mHnHu*j+hm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu$jhm|$hc.0JUmHnHu)hc.5CJOJQJaJmHnHsHtH|qq_I*j.hm|$hc.0JUmHnHu#jc.hc.UmHnHuhc.mHnHu*j-hm|$hc.0JUmHnHuhc.mHnHuhm|$hc.0JmHnHu,hc.5CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHuh@7mHnHujhc.UmHnHu#ji-hc.UmHnHu&'(BCDFGHIJKghijrst׺קq_׺קRIhm|$hc.0Jjhm|$hc.0JU#jW0hc.UmHnHu*j/hm|$hc.0JUmHnHuhc.mHnHu,hc.5CJOJQJaJmHnHsHtHu$jhm|$hc.0JUmHnHuh@7mHnHu#j]/hc.UmHnHujhc.UmHnHuhc.mHnHuhm|$hc.0JmHnHuvwx¸«֑|wsle_YPY_J h-CJh#|h#|CJ h#|CJ h\wCJ h"hC h<hlh< hl5 hlCJ hXphbjhbU)hc.5CJOJQJaJmHnHsHtH h@7jQ1hc.Ujhc.U hc.hm|$hc.0JmHnHsH jhm|$hc.0JUj0hm|$hc.0JUhm|$hc.0Jhc.3567~)\|  &)*+о覠uhbhfj.0JCJj1h1sh1sCJUjhbCJU h$xdCJ hcCJ hfj.CJ h67CJ haCJ hw:CJ h}-CJ hJACJ hHCJ hlCJ h\wCJ hCJ h=3UCJ h#|CJ h-CJ h CJ hbCJ.  % 7 W Z [ \ f g s x y ~ 0!L!N!n!!!!!! ","/"0"1":"f"""" hh(CJ hJACJ huCJ h|1CJ hl6CJ hLCJ hlCJ hZ8sCJ h;CJ h^CJ hfj.CJ hB,CJ hCJhUhvCCJhUh$xdCJ hbCJ hvCCJ hUCJ hcCJ h$xdCJ2M!N!###-#.#8#9#S####$$$%% $ h1$a$gdE38^8gdC$a$gdT $ h1$a$gdTgd< & Fgd<gdI& $ 9r a$$a$gdh($a$""#####.#2#8#9#?#D#S####-$2$8$$$$$$%%%%%%Z&m&&&&̨됅xpjdj[hGoahGoaCJ hGoaCJ hQfCJhQfmH sH  hChQf he@CJh<h<mH sH hC5CJmH sH  hT6CJ hE3CJh<hlmH sH  hTCJhTmH sH h<hTmH sH h<mH sH  hl5hQfh<hl h) "CJ hlCJ hh(CJhB,hh(CJ#%%&&&''+),)b*c*,,6,,,--j/k/00w1gd%MgdeKgdbgdbgdC1$gdZ8sgdZ  & Fgd<$a$$a$gdQf & Fgd<&&&&&&&&&&&&S'T'U't'u'''''''''''(((_(w(|((((((((ȸέޤ؞wqkkek h?CJ h!"<CJ hCftCJhvhCJ hN:CJ hGoaCJ h\wCJ hCJ hQCJ hTCJh'Fh'FCJhxSGhl0JCJj2h1sh1sCJU hvCJjhxSGCJU hlCJ h'CJ hQfhl hQfh\w hCh\w hChQf'((((()))')()*)+),)-)**%*L*a*b*c****+++-+0+3+4+7+8+:+;+<+>+A+B+C+ý÷~u~u~oo hTCJh]uhTCJh]uhFCJ hFCJhp2GhQfCJ hQfCJhChCCJh)wh=>CJhh=>CJ h=>CJ h67CJ hZ8sCJhvhv0JCJj4h1sh1sCJUjhvCJU hvCJ h?CJ hA%CJ'C+D+,,,,&,',5,6,L,[,p,r,s,t,,,,,,,,J-n-u---------A.C.H.P.[......//|sh heKCJ hoCJ heKCJhhhheKCJh heKCJhhheKCJhg+mH sH hhh%=qmH sH hhhcmH sH hhhbmH sH h67h\(nHtHhQfCJ^JnHtH$h67hpUCJOJQJ^JnHtHhhQfCJ^J-/'/+/,/-/?/i/j/k/////D0N0P0Z0\0f0h0r0w00000000000111նեsg[hhh0JCJhhhh0JCJh"j4hhhvCJUh hvCJhjhhhBCJUhhhhCJhhhh8FJCJh hSCJhhpj$hS6CJhhhheK6CJh heKCJhhhheKCJh heKCJh heKCJh heKCJ] heKCJ]"1 1*1/18191W1v1w1x1111)2;2c2u222H3Z3333344I4T4U4W4l4|4}4~444444K5ztnthnhnht hCJ hP/CJ hqCJ hwhq h=>CJjh=>U h=>CJh hbCJh hpj$CJh hH7CJh h%MCJh htDWCJh h\CJh hCJhhhh+CJhhh56CJhhh6CJ h\CJhhhCJhhhCJh(w1x12244T4V4W4l444M5N5q56688888gdQf$a$gdCC} $ 9r a$gdCC}$a$gdb & Fgd? $ 9r a$gdq & Fgd<gd=>gd%MK5L5N5T5X5\5q5w5x5555555555666666666666666666667 767<7F7X7^7c7777777778ͻǻǵܯܯܩܯ hv CJhQYhpUCJhpUhpUCJ hpUCJ hZ8sCJ hE"CJ hpj$CJ h1mCJ hx3*CJ hwCJ hbCJh{rhCC}CJ hCC}CJhCC} hCC}hCC} hChCC} hqCJ h,MCJ68 888D8I8S8q8u8w88888888888999999999h:i:j:|qgaQgjG6h1sh1sCJU hvCJjhvCJUh]hq0JCJjf5h]hqCJUh]hqCJjh]hqCJU hqCJhqmH sH hySmH sH hmH sH  hhU hhhh hChhhCC} hwCJ hCJ hCC}CJ h,MCJhQYhpUCJ hpj$CJ888Y;Z;;;;===>>>??>@?@@@S@JA$a$gd%*gd"gd%*  & F gd?> & FgdgdqgdkgdyS$a$gdq gdgdj:~:::::;4;7;C;G;J;M;Q;W;X;Y;Z;;;;;;<<=======%>ǽ嚑{shshsd{[hQYhqCJhkhk6CJ]^JhkCJ^JhqmH sH hmH sH  hySCJh?h?CJ he@CJhmUhCJ\hmUh >CJ\hmUhCJhmUhCJ\hmUhCJ hCJhhCJ hCJ hqCJjhvCJUhvhq0JCJ %>&>>>>>>>>>>>?I?N?]?b?e?x??????? @=@>@?@@@F@R@S@T@_@r@}@@@@zvzpjpjdjp hICJ hlCJ hCCJh hhl h"h hgCJhBhgCJ hNsCJ h:CJh VhgCJ hgCJ hghg h^jhg h5aJhq hqCJhQYhq0JCJjr7h1sh1sCJU hvCJjhQYhqCJU'@@@@@@@@@@@@@AA*A+A,A9AGAHAIAKAOAPAAAAAAAʺ|rl\rQr|hKMhNs0JCJjD9h1sh1sCJU hKMCJjhKMCJU hNsCJ hbCJ hS5CJh6hR0JCJh6h 0JCJj8h1sh1sCJU h6CJjh6CJU h CJ h CJ hZ CJ h6CJ hA%CJ h^ CJ h\ACJ h$#CJ h\wCJ hCJJAKABBBCCC_D`DjDDDEE!FF$ & F 9r a$gd?  9r gdB $ 9r a$gd $a$gd  gdgdw ,7$],gdwgd$a$ & Fgd?> & Fgd$a$gdNs$a$gd%*ABBBBBBBBBCCCCCCCCC_D`DfDjDDDDDDEEEE'ENE`ElEyE}EEEEEEEEEEüψψς|v|v|vvvv hCJ hcmCJ h(tCJ hBCJ h CJhwhwmH sH hmH sH h%M hwCJ h h h q hh%* h'_*CJ h{!sCJ hlCJ hJCJ h`CJhl hCJ hCJ hNsCJhNshNsCJ.EFFF F%F*FIFJFFFFGGaGjGkGoGpGGGGGGGGGGGGľĵxmd[dUd h|CJhBhBCJhBhCJh*&h|0JCJh*&h0JCJj:h*&h*&CJU h*&CJjh*&CJUh hCJh hCJh hlCJ hlCJhlhlCJ hBCJ h CJh h CJ h(tCJ h9CJ hpECJ h-^CJ hlCJGGGGGGhHiHHHHHHzIIIIII7JVJZJ^JJJJJJJJJJKyK{KҸȭҧңҕҕҋuj_jY hwCJh6h q0JCJh6h_M0JCJj;h1sh1sCJU h6CJjh6CJU h {]CJh_MmH sH h_M hUCJh Th_M0JCJj ;h Th_MCJUjh_MCJU h_MCJh qh_MmH sH hmH sH  hlCJ hlCJhBhJCJ"FGGGIIIKKKKKKNNNN|O}OOOP $ 9r a$gds & Fgd?gd_M $ 9r a$gd_M$a$gd_M gd $ 9r a$ $ & Fa$gd?{K|KKKKKKKKKK2O3OUOVOWOmOnOpO|O}OOOOOOOOOPPPʽ{uofofou`\UQUh0N hwhQ8hq hCJh99hwCJ h99CJ hwCJh Ths0JCJjrh ThsCJUh ThsCJjh ThsCJU hsCJ hwhshCWhmHnHsHtHu(j<hCWhCWUmHnHsHtHu hpj$CJhh_MCJ hbxCJ h_MCJ hCWCJPPPPPQQQ9Q:QxQzQQQQQRRCRGRlRRRRRSSS S S!S"S>S?SFSNSUSVSSSSST~xrl~ hm2CJ h`CJ hJCJ hlCJ hwhR hwhlh hh82 h82h82h82 h {]CJ hCJ h"}CJ h6CJ h\ CJhhQ80JCJj}shI&h*CJU hI&CJjhhQ8CJU hwCJ hQ8CJ*PQQCRDR!S"S>S?SVSTT8TUUU7W8WNWXX Y & Fgd? $ 9r a$gdJgd!$a$gdgd & Fgd?gd"gd"}$a$gdQ8TTTT$T8TpTTTTTUUPUQUUUUUUUUUUU`VaVhVVVVVVVVVVWŻxoxfx`x hCJhJh9H|CJhJh`CJhJhlCJ hJCJ h@-CJ hiGCJ h"hqhXh0JCJjthI&h*CJU hI&CJjhXCJU hCJ hCJ hrCJh{a1hlmH sH h{a1hmH sH  h"hl hlCJ h`CJ%WW5W6W7W8WNWWWWWWWX/X0X1X5XCXFXOXVXbXdXkXsX~XXXXXXXXXXXXXڼζڶ{pjfhF h0NCJh6hR0JCJjuh1sh1sCJU h6CJjh6CJU hCJ hRCJ hkCJhrKh$^CJ haGCJ h'CJ hn^CJ hiGCJ hxCJ h CJ hlCJhlh!h!h!CJhJhlCJ hJCJ&X YYYgZZZZZ[ ["[%[&[)[B[I[S[b[l[s[u[[[[[[[[[[[\\;\O\S\T\U\`\r\{\\\\\\$]8]9]:];]<]új.vhX8hbCJU hD!CJ hbCJ h/&VCJhD!hD!CJhD!h8y-CJhD!hy,CJhD!hRCJhD!hJGCJ hpj$CJ hK CJ hJGCJ h6CJ h\ CJ hRCJ hRhR4 YYYT\U\:];]=]>]]]7^8^__,_____8`b``$ & F *$a$gd?gd$j & Fgd?$a$gd&\$a$gdq$a$gdb$a$gdR<]=]>]],^4^7^8^^^^^^^____,_____``A`V`b`w```\a]aaaaabֹɮߧ}vpjp h "CJ hCJ h hlhhlmH sH  h"h$jh?h$jCJhB2h$jCJ h$jCJ h$jh$jh&\h&\0JCJjh1sh1sCJUjh&\h&\CJUh&\h&\CJ hbxCJ h%}CJhD!hbCJ hbCJ hX8CJ%`\a]aabbccQeReoegghhEh_iSjTjvj & F h^`gd<gd  & Fgd<gdI&gd ,gd$a$gd & Fgd?gd"$ & F *$a$gd?bcc~ccccccccddddddee eeeeeee eKePeQeReoee鳩wle_[Rh~hCJh h#:=CJ hhhh0JCJjh1sh1sCJU hvCJjhhCJUhhCJ hCJhy,CJmH sH hCJmH sH hmLh0JCJmH sH jZh1sh1sCJUh{a1hXCJmH sH jhmLhCJUhCJmH sH  eeeeeeeeeefgggg.g6g7gvgwgxg{g|g~gggggggggggghɾ긯{k{d`\h h< h ,h ,jh~hCJUh~h0JCJjh~hCJUjh~hCJU hvCJ hV#(CJh~hCJ h=CJh6h0JCJh6hU0JCJj*h1sh1sCJU h6CJjh6CJU hUCJ hCJ#hh hh&h0h?hEhFhZhghkhhhhhhi i i2i3i4iOiPiQi]i^iii6j7j8jPjQjRjTjYjƼƬ՘rg` h h ho hP/0JCJj hI&h*CJU hI&CJjho CJU hP/CJhP/hP/CJh6hv0JCJjeh1sh1sCJUjhvCJU hvCJh|&h CJ h CJh[Ph CJ hGCJh  hhnh h< h"h %YjZj`jajbjkjujvjjj%k>kPkTkUk{k|k}kkkkkk/l:l?lDlElvlwlxllllmmommmmmmmmnnnnҷ豭{ hH7hY hg+CJh#:=hXMCJh#:=hYCJhY hhnhYhg<_hbKh]?A h]?ACJh6hAh0JCJjh1sh1sCJUjhAhCJU hYCJ hAhCJ h CJ h h  h h h -vjkkvlwlxllnnnnoppprUt-v_v4 $gdI&  & F# $gdI& 4$ $a$gdI&gdI& $gdI& gdXo & F h^`gd<$a$gd .gdbKgd]?Agd nnnnnnnnnpppp`qjqr0t9t-v0v_vvvRwfww·th`UCh"h2D2h{5CJ\aJmH sH h#:=h{mH sH hXmH sH h|&CJaJmH sH hhCJaJmH sH  hh{hMJhh{CJaJmH sH h2D2h{CJaJmH sH  h#:=h{hXhmUh:mH sH h{a1h0J@mH sH h{a1h 50J@mH sH hmU0J@mH sH h{a1h 0J@mH sH hg+hX0J@mH sH _v`vvqwLxxyGyyz|zz{2{{{{{{k|4$ $r^`ra$gdI&4 $r^`rgdI&gdI& 4 & F $gdI& 4 & F $gdI& 4 & F $gdI& 4$ $a$gdI&4 $gdI&wwwxBxJx~x{{{{{{(~)~tDzyfySyOH5%hXh{B*CJaJmH phsH  h#:=h{hX%hh(++B*CJaJmH phsH %hhB*CJaJmH phsH %hh{B*CJaJmH phsH %h2D2h{B*CJaJmH phsH h#:=h{mH sH hXmH sH (h2D2hi5B*CJaJmH phsH hI&CJaJmH sH h2D2hI&CJaJmH sH h2D2h{CJaJmH sH h2D2hCJaJmH sH k|||||}}Y~~~~o]4 & F $r^`rgdI&4 & F $r^`rgdI&4 & F $r^`rgdI&4 & F $V^`VgdI&4 & F $r^`rgdI&4 & F $r^`rgdI&4 & F $r^`rgdI&4 & F $r^`rgdI&4 & F $r^`rgdI& ~.=>bc'Ӂԁ IR $$IfgdI& $gdI& $gdI&gdI&4 $r^`rgdI&4 & F $ hV^`VgdI&4 & F $V^`VgdI&:<=>EFGObc&'-./78ӁԁIļ؝vvvmvd[R[Nh{a1h,hnLCJh,h{a1CJh,h<.eCJh,h}sCJh,hCJh,hbCJh,hWZCJh,hP/6>*CJh,hP/CJh"hmH sH h"hemH sH hmUmH sH h"hhTmH sH h:vhtiCJhWZhCJmH sH h2D2hiCJmH sH h2D2h{CJmH sH IRUVԂ݂ 89BxyzIJPQT\]`ôëëëho$>*B*CJph h%}CJ h{a1CJhJQ h{a1CJh{a1h{a1>*B*CJphh{a1h{a1CJhi] hi]h{a1h{a1h~mH sH h,hP/CJmH sH h{a1hPch{a1>*B*ph:RSTUVqfff $$IfgdI&kd$$IflF8" p( t0"6    44 laVW`qfff $$IfgdI&kd`$$IflF8" p( t0"6    44 laqfff $$IfgdI&kd$$IflF8" p( t0"6    44 laqfff $$IfgdI&kd$$IflF8" p( t0"6    44 laqfff $$IfgdI&kdX$$IflF8" p( t0"6    44 laԂ݂qfff $$IfgdI&kd$$IflF8" p( t0"6    44 la݂ނ߂qfff $$IfgdI&kd$$IflF8" p( t0"6    44 la qfff $$IfgdI&kdP$$IflF8" p( t0"6    44 la 89ByzqkkkbYY $IfgdI& $IfgdI& $gdI&kd$$IflF8" p( t0"6    44 laz{qhhh $IfgdI&kd$$IflF8" p( t0"6    44 laqhhh $IfgdI&kdH$$IflF8" p( t0"6    44 laqhhh $IfgdI&kd$$IflF8" p( t0"6    44 laJTqhhh $IfgdI&kd$$IflF8" p( t0"6    44 laTUVqhhh $IfgdI&kd@$$IflF8" p( t0"6    44 la qhhh $IfgdI&kd$$IflF8" p( t0"6    44 la "#'UV\]aijmņƆʆ҆ӆ׆'(./3MR|Ƈ̇#%DEKpqwȈΈhh{a1CJ hCJhhCJh{a1h{a1CJ h%}CJho$>*B*CJphh{a1h{a1>*B*CJphhJQ h{a1CJG qhhh $IfgdI&kd$$IflF8" p( t0"6    44 laqhhh $IfgdI&kd8$$IflF8" p( t0"6    44 laVaqhhh $IfgdI&kd$$IflF8" p( t0"6    44 laabcʆqhhh $IfgdI&kd$$IflF8" p( t0"6    44 laʆˆ̆(3qhhh $IfgdI&kd0$$IflF8" p( t0"6    44 la349MRqhhh $IfgdI&kd$$IflF8" p( t0"6    44 laRSY|qhhh $IfgdI&kd$$IflF8" p( t0"6    44 laqhhh $IfgdI&kd($$IflF8" p( t0"6    44 laƇ̇qhhh $IfgdI&kd$$IflF8" p( t0"6    44 lȧ͇·qhhh $IfgdI&kdx$$IflF8" p( t0"6    44 la#qhhh $IfgdI&kd $$IflF8" p( t0"6    44 la#$%EKqhhh $IfgdI&kd$$IflF8" p( t0"6    44 laKLMqwqhhh $IfgdI&kdp$$IflF8" p( t0"6    44 lawxyqhhh $IfgdI&kd$$IflF8" p( t0"6    44 laȈΈqhhh $IfgdI&kd$$IflF8" p( t0"6    44 laΈψЈqhhh $IfgdI&kdh$$IflF8" p( t0"6    44 laqhhh $IfgdI&kd$$IflF8" p( t0"6    44 la;ABCjopqى߉GMntŠ ,2Z`pvދ݌MSgm}ɼh{a1hH>*B*CJphhJQ hHCJh{a1h~h{a1>*B*phh~h{a1>*B*CJphhh3h{a1CJ h:vh{a1h{a1h{a1>*B*CJphhJQ h{a1CJ<;Aqhhh $IfgdI&kd$$IflF8" p( t0"6    44 laABCjpqhhh $IfgdI&kd`$$IflF8" p( t0"6    44 lapqrqhhh $IfgdI&kd$$IflF8" p( t0"6    44 laqhhh $IfgdI&kd$$IflF8" p( t0"6    44 la‰ى߉qhhh $IfgdI&kdX$$IflF8" p( t0"6    44 la߉qhhh $IfgdI&kd$$IflF8" p( t0"6    44 laqhhh $IfgdI&kd$$IflF8" p( t0"6    44 la !GMqhhh $Ifgd~kdP$$IflF8" p( t0"6    44 laMNOntqhhh $Ifgd~kd$$IflF8" p( t0"6    44 latuvqhhh $Ifgd~kd$$IflF8" p( t0"6    44 laŠqhhh $Ifgd~kdH$$IflF8" p( t0"6    44 laŠÊĊqhhh $Ifgd~kd$$IflF8" p( t0"6    44 la qhhh $Ifgd~kd$$IflF8" p( t0"6    44 la,2qhhh $Ifgd~kd@$$IflF8" p( t0"6    44 la239BHqhhh $Ifgd~kd$$IflF8" p( t0"6    44 laHIJZ`qhhh $Ifgd~kd$$IflF8" p( t0"6    44 la`abpvqhhh $Ifgd~kd8$$IflF8" p( t0"6    44 lavw}qhhh $Ifgd~kd$$IflF8" p( t0"6    44 laދqhhh $Ifgd~kd$$IflF8" p( t0"6    44 laqhhh $Ifgd~kd0$$IflF8" p( t0"6    44 la Z`qhhh $Ifgd~kd$$IflF8" p( t0"6    44 la`abqhhh $Ifgd~kd$$IflF8" p( t0"6    44 laqccc $7$8$H$Ifgd kd($$IflF8" p( t0"6    44 la݌qccc $7$8$H$Ifgd kd$$IflF8" p( t0"6    44 laqccc $7$8$H$Ifgd kdx$$IflF8" p( t0"6    44 la qccc $7$8$H$Ifgd kd $$IflF8" p( t0"6    44 la :>qccc $7$8$H$Ifgd kd$$IflF8" p( t0"6    44 la>?EMSqccc $7$8$H$Ifgd kdp$$IflF8" p( t0"6    44 laSTZgmqccc $7$8$H$Ifgd kd$$IflF8" p( t0"6    44 lamnt}qccc $7$8$H$Ifgd kd$$IflF8" p( t0"6    44 laōqccc $7$8$H$Ifgd kdh$$IflF8" p( t0"6    44 laōƍ̍qccc $7$8$H$Ifgd kd $$IflF8" p( t0"6    44 laFUqccc $7$8$H$Ifgd kd $$IflF8" p( t0"6    44 la<.4 06UVcghlm#'(gh͑בؑ2Ӿ񺳬~~~~~h~hf>*B*CJphhJQ hfCJhfhWZhf^Jhh3hf^J hyhf h{a1h{a1h{a1h U:h U:>*B* CJphp hCCJhJQ h U:CJ h U:CJh{a1hH>*B*CJphhJQ hHCJ hh3CJ1UV\qccc $7$8$H$Ifgd kd` $$IflF8" p( t0"6    44 laqccc $7$8$H$Ifgd kd $$IflF8" p( t0"6    44 laŎqccc $7$8$H$Ifgd kd $$IflF8" p( t0"6    44 laqccc $7$8$H$Ifgd kdX $$IflF8" p( t0"6    44 la &.4qccc $7$8$H$Ifgd kd $$IflF8" p( t0"6    44 la45;?Nqccc $7$8$H$Ifgd kd $$IflF8" p( t0"6    44 laNOS|qccc $7$8$H$Ifgd kdP$$IflF8" p( t0"6    44 laqccc $7$8$H$Ifgd kd$$IflF8" p( t0"6    44 laqccc $7$8$H$Ifgd kd$$IflF8" p( t0"6    44 laƏqccc $7$8$H$Ifgd kdH$$IflF8" p( t0"6    44 la qccc $7$8$H$Ifgd kd$$IflF8" p( t0"6    44 la06qccc $7$8$H$Ifgd kd$$IflF8" p( t0"6    44 la67;cgqccc $7$8$H$Ifgd kd@$$IflF8" p( t0"6    44 laghmqccc $7$8$H$Ifgd kd$$IflF8" p( t0"6    44 laqccc $7$8$H$Ifgd kd$$IflF8" p( t0"6    44 laАѐqccc $7$8$H$Ifgd kd8$$IflF8" p( t0"6    44 laqkkbYY $Ifgdf $IfgdI& $gdI&kd$$IflF8" p( t0"6    44 la#'qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la'(.agqhhh $Ifgdfkd0$$IflF8" p( t0"6    44 laghrqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la͑בqhhh $Ifgdfkd($$IflF8" p( t0"6    44 laבؑqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la2<qhhh $Ifgdfkdx$$IflF8" p( t0"6    44 la2<=`jkݒ $./S]^“֓XbcҔڔ۔3=>aklĕ͕̕qyz–ܖhwhf>*B*CJph hh3CJhJQ hfCJhfh~hf>*B*CJphR<=G`jqhhh $Ifgdfkd $$IflF8" p( t0"6    44 lajkuqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkdp$$IflF8" p( t0"6    44 laɒݒqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la $.qhhh $Ifgdfkdh$$IflF8" p( t0"6    44 la./9S]qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la]^hqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd`$$IflF8" p( t0"6    44 la“̓֓qhhh $Ifgdfkd $$IflF8" p( t0"6    44 laqhhh $Ifgdfkd $$IflF8" p( t0"6    44 la(Xbqhhh $IfgdfkdX!$$IflF8" p( t0"6    44 labcmqhhh $Ifgdfkd"$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd"$$IflF8" p( t0"6    44 laҔڔqhhh $IfgdfkdP#$$IflF8" p( t0"6    44 laڔ۔qhhh $Ifgdfkd#$$IflF8" p( t0"6    44 la3=qhhh $Ifgdfkd$$$IflF8" p( t0"6    44 la=>Hakqhhh $IfgdfkdH%$$IflF8" p( t0"6    44 laklvqhhh $Ifgdfkd%$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd&$$IflF8" p( t0"6    44 laĕ̕qhhh $Ifgdfkd@'$$IflF8" p( t0"6    44 la͕̕Օqhhh $Ifgdfkd'$$IflF8" p( t0"6    44 la'qyqhhh $Ifgdfkd($$IflF8" p( t0"6    44 layzqhhh $Ifgdfkd8)$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd)$$IflF8" p( t0"6    44 la–Ɩܖqhhh $Ifgdfkd*$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd0+$$IflF8" p( t0"6    44 la-3qhhh $Ifgdfkd+$$IflF8" p( t0"6    44 la34IQRwٗ 9ABgopۘCKLowxƙ˙ΙЙٙ+,fg󴫢 hfhfhWZhf^Jh%1hf^J hWZhf h~hf0J>*B*CJphhh3hf>*B*CJphhh3hfCJh~hf>*B*CJphhfhJQ hfCJ934<IQqhhh $Ifgdfkd,$$IflF8" p( t0"6    44 laQRZwqhhh $Ifgdfkd(-$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd-$$IflF8" p( t0"6    44 laٗqhhh $Ifgdthkdx.$$IflF8" p( t0"6    44 la qhhh $Ifgdfkd /$$IflF8" p( t0"6    44 la9Aqhhh $Ifgdfkd/$$IflF8" p( t0"6    44 laABJgoqhhh $Ifgdfkdp0$$IflF8" p( t0"6    44 laopvqhhh $Ifgdfkd1$$IflF8" p( t0"6    44 laۘqhhh $Ifgdfkd1$$IflF8" p( t0"6    44 laqhhh $Ifgdfkdh2$$IflF8" p( t0"6    44 la&CKqhhh $Ifgdfkd3$$IflF8" p( t0"6    44 laKLTowqhhh $Ifgdfkd3$$IflF8" p( t0"6    44 lawxqhhh $Ifgdfkd`4$$IflF8" p( t0"6    44 laƙΙqhhh $Ifgdfkd5$$IflF8" p( t0"6    44 laΙϙЙٙqkbYY $Ifgdf $IfgdI& $gdI&kd5$$IflF8" p( t0"6    44 laqhhh $IfgdfkdX6$$IflF8" p( t0"6    44 la%+qhhh $Ifgdfkd7$$IflF8" p( t0"6    44 la+,4^fqhhh $Ifgdfkd7$$IflF8" p( t0"6    44 lafgqqhhh $IfgdfkdP8$$IflF8" p( t0"6    44 laɚӚԚDEuڛ$%q{|˜̜PQڝ%&U_`)*ist,-pz{ՠߠTUϡ١ڡ h%1hf>*B*CJphh%1hfCJhJQ hfCJhfhwhf>*B*CJphPɚӚqhhh $Ifgdfkd8$$IflF8" p( t0"6    44 laӚԚޚqhhh $Ifgdfkd9$$IflF8" p( t0"6    44 la<Dqhhh $IfgdfkdH:$$IflF8" p( t0"6    44 laDEOuqhhh $Ifgdfkd:$$IflF8" p( t0"6    44 laڛqhhh $Ifgdfkd;$$IflF8" p( t0"6    44 la$qhhh $Ifgdfkd@<$$IflF8" p( t0"6    44 la$%/q{qhhh $Ifgdfkd<$$IflF8" p( t0"6    44 la{|˜qhhh $Ifgdfkd=$$IflF8" p( t0"6    44 la˜̜֜qhhh $Ifgdfkd8>$$IflF8" p( t0"6    44 la!HPqhhh $Ifgdfkd>$$IflF8" p( t0"6    44 laPQ[qhhh $Ifgdfkd?$$IflF8" p( t0"6    44 laڝqhhh $Ifgdfkd0@$$IflF8" p( t0"6    44 la%qhhh $Ifgdfkd@$$IflF8" p( t0"6    44 la%&0U_qhhh $IfgdfkdA$$IflF8" p( t0"6    44 la_`jqhhh $Ifgdfkd(B$$IflF8" p( t0"6    44 laqhhh $IfgdfkdB$$IflF8" p( t0"6    44 la)qhhh $IfgdfkdxC$$IflF8" p( t0"6    44 la)*4isqhhh $Ifgdfkd D$$IflF8" p( t0"6    44 last|qhhh $IfgdfkdD$$IflF8" p( t0"6    44 lağqhhh $IfgdfkdpE$$IflF8" p( t0"6    44 la$,qhhh $IfgdfkdF$$IflF8" p( t0"6    44 la,-7pzqhhh $IfgdfkdF$$IflF8" p( t0"6    44 laz{ՠߠqhhh $IfgdthkdhG$$IflF8" p( t0"6    44 laߠqhhh $IfgdfkdH$$IflF8" p( t0"6    44 la NTqhhh $IfgdfkdH$$IflF8" p( t0"6    44 laTU]qhhh $Ifgdfkd`I$$IflF8" p( t0"6    44 laϡ١qhhh $IfgdfkdJ$$IflF8" p( t0"6    44 la١ڡ qhhh $IfgdfkdJ$$IflF8" p( t0"6    44 la"T^qhhh $IfgdfkdXK$$IflF8" p( t0"6    44 laT^_ԢޢߢBLMDNOBLMե֥XbcFPQ$%q{|ߨ",-FGߩ 8BCfpqêĪhfhwhf>*B*CJphhJQ hfCJZ^_gqhhh $IfgdfkdL$$IflF8" p( t0"6    44 laԢޢqhhh $IfgdfkdL$$IflF8" p( t0"6    44 laޢߢBLqhhh $IfgdfkdPM$$IflF8" p( t0"6    44 laLMWqhhh $IfgdfkdM$$IflF8" p( t0"6    44 laqhhh $IfgdfkdN$$IflF8" p( t0"6    44 laDNqhhh $IfgdfkdHO$$IflF8" p( t0"6    44 laNOYqhhh $IfgdfkdO$$IflF8" p( t0"6    44 laݤqhhh $IfgdfkdP$$IflF8" p( t0"6    44 laBLqhhh $Ifgdfkd@Q$$IflF8" p( t0"6    44 laLMWqhhh $IfgdfkdQ$$IflF8" p( t0"6    44 laͥեqhhh $IfgdfkdR$$IflF8" p( t0"6    44 laե֥qhhh $Ifgdfkd8S$$IflF8" p( t0"6    44 la#Xbqhhh $IfgdfkdS$$IflF8" p( t0"6    44 labcmqhhh $IfgdfkdT$$IflF8" p( t0"6    44 laŦqhhh $Ifgdfkd0U$$IflF8" p( t0"6    44 laFPqhhh $IfgdfkdU$$IflF8" p( t0"6    44 laPQYqhhh $IfgdfkdV$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd(W$$IflF8" p( t0"6    44 la$qhhh $IfgdfkdW$$IflF8" p( t0"6    44 la$%/q{qhhh $IfgdfkdxX$$IflF8" p( t0"6    44 la{|ߨqhhh $Ifgdfkd Y$$IflF8" p( t0"6    44 la",qhhh $IfgdfkdY$$IflF8" p( t0"6    44 la,-3@Fqhhh $IfgdfkdpZ$$IflF8" p( t0"6    44 laFGOqhhh $Ifgdfkd[$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd[$$IflF8" p( t0"6    44 laߩqhhh $Ifgdfkdh\$$IflF8" p( t0"6    44 la qhhh $Ifgdfkd]$$IflF8" p( t0"6    44 la 8Bqhhh $Ifgdfkd]$$IflF8" p( t0"6    44 laBCMfpqhhh $Ifgdfkd`^$$IflF8" p( t0"6    44 lapq{qhhh $Ifgdfkd_$$IflF8" p( t0"6    44 laêqhhh $Ifgdfkd_$$IflF8" p( t0"6    44 laêĪ̪٪qhhh $IfgdfkdX`$$IflF8" p( t0"6    44 laĪ *+oyz()CMN}~%/0KUVޭ!"LVW߮%/0`lmįů&./PXYsthwhf>*B*CJphhfhJQ hfCJZqhhh $Ifgdfkda$$IflF8" p( t0"6    44 la *qhhh $Ifgdfkda$$IflF8" p( t0"6    44 la*+5oyqhhh $IfgdfkdPb$$IflF8" p( t0"6    44 layzqhhh $Ifgdfkdb$$IflF8" p( t0"6    44 laƫqhhh $Ifgdfkdc$$IflF8" p( t0"6    44 la (qhhh $IfgdfkdHd$$IflF8" p( t0"6    44 la()3CMqhhh $Ifgdfkdd$$IflF8" p( t0"6    44 laMNXn}qhhh $Ifgdfkde$$IflF8" p( t0"6    44 la}~qhhh $Ifgdfkd@f$$IflF8" p( t0"6    44 laƬqhhh $Ifgdfkdf$$IflF8" p( t0"6    44 la%/qhhh $Ifgdfkdg$$IflF8" p( t0"6    44 la/0:KUqhhh $Ifgdfkd8h$$IflF8" p( t0"6    44 laUV^qhhh $Ifgdfkdh$$IflF8" p( t0"6    44 laqhhh $Ifgdfkdi$$IflF8" p( t0"6    44 laȭޭqhhh $Ifgdfkd0j$$IflF8" p( t0"6    44 la!qhhh $Ifgdfkdj$$IflF8" p( t0"6    44 la!",LVqhhh $Ifgdfkdk$$IflF8" p( t0"6    44 laVWaqhhh $Ifgdfkd(l$$IflF8" p( t0"6    44 laqhhh $Ifgdfkdl$$IflF8" p( t0"6    44 la׮߮qhhh $Ifgdfkdxm$$IflF8" p( t0"6    44 la߮qhhh $Ifgdfkd n$$IflF8" p( t0"6    44 la%/qhhh $Ifgdfkdn$$IflF8" p( t0"6    44 la/0<`lqhhh $Ifgdfkdpo$$IflF8" p( t0"6    44 lalmwqhhh $Ifgdfkdp$$IflF8" p( t0"6    44 laįqhhh $Ifgdfkdp$$IflF8" p( t0"6    44 laįůϯqhhh $Ifgdfkdhq$$IflF8" p( t0"6    44 la&.qhhh $Ifgdfkdr$$IflF8" p( t0"6    44 la./7PXqhhh $Ifgdfkdr$$IflF8" p( t0"6    44 laXYaksqhhh $Ifgdfkd`s$$IflF8" p( t0"6    44 last~qhhh $Ifgdfkdt$$IflF8" p( t0"6    44 laqhhh $Ifgdfkdt$$IflF8" p( t0"6    44 laqhhh $IfgdfkdXu$$IflF8" p( t0"6    44 la%:@qhhh $Ifgdfkdv$$IflF8" p( t0"6    44 la:@AYZıű8@A{IJŲղزٲڲ(*AB[\ȳгѳ &./?GHlm}hVhf>*B*CJphh(hf^J hWZhf hwhf0J>*B*CJphhwhf>*B*CJphhJQ hfCJhfG@AGSYqhhh $Ifgdfkdv$$IflF8" p( t0"6    44 laYZbqhhh $IfgdfkdPw$$IflF8" p( t0"6    44 laıqhhh $Ifgdfkdw$$IflF8" p( t0"6    44 laıűͱqhhh $Ifgdfkdx$$IflF8" p( t0"6    44 la8@qhhh $IfgdfkdHy$$IflF8" p( t0"6    44 la@AI{qhhh $Ifgdfkdy$$IflF8" p( t0"6    44 laqhhh $Ifgdfkdz$$IflF8" p( t0"6    44 laIJqhhh $Ifgdfkd@{$$IflF8" p( t0"6    44 laIJŲɲղٲqhhh $Ifgdfkd{$$IflF8" p( t0"6    44 laٲڲ޲qhhh $Ifgdfkd|$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd8}$$IflF8" p( t0"6    44 la()qkbYY $Ifgdf $IfgdI& $gdI&kd}$$IflF8" p( t0"6    44 la)*.=Aqhhh $Ifgdfkd~$$IflF8" p( t0"6    44 laABHU[qhhh $Ifgdfkd0$$IflF8" p( t0"6    44 la[\d}qhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd($$IflF8" p( t0"6    44 laȳгqhhh $IfgdfkdЁ$$IflF8" p( t0"6    44 laгѳٳqhhh $Ifgdfkdx$$IflF8" p( t0"6    44 la qhhh $Ifgdfkd $$IflF8" p( t0"6    44 la&.qhhh $Ifgdfkdȃ$$IflF8" p( t0"6    44 la./0?Gqhhh $Ifgdfkdp$$IflF8" p( t0"6    44 laGHPdlqhhh $Ifgdfkd$$IflF8" p( t0"6    44 lalmn}qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la},45;KRSZ[еصٵ &'(7?@TU]^_mnvwxĶŶƶhVhf>*B*CJhphhJQ hfCJhhJQ hfCJhfhVhf>*B*CJphPqhhh $Ifgdfkdh$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd`$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la,4qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la45;LRqhhh $IfgdfkdX$$IflF8" p( t0"6    44 laRS[qhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $IfgdfkdP$$IflF8" p( t0"6    44 laеصqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laصٵqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la qhhh $IfgdfkdH$$IflF8" p( t0"6    44 la &qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la&'(7?qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la?@HU]qhhh $Ifgdfkd@$$IflF8" p( t0"6    44 la]^_nvqhhh $Ifgdfkd$$IflF8" p( t0"6    44 lavwxqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd8$$IflF8" p( t0"6    44 laĶqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laĶŶƶնݶqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laƶԶնݶ޶߶!"*+,:;CDET\]^muv̷ͷշַ׷  !FGOPQ_`hijyظٸڸ #$@AIJhfhVhf>*B*CJhphhJQ hfCJhhJQ hfCJVݶ޶߶qhhh $Ifgdfkd0$$IflF8" p( t0"6    44 laqhhh $Ifgdfkdؔ$$IflF8" p( t0"6    44 la"*qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la*+,;Cqhhh $Ifgdfkd($$IflF8" p( t0"6    44 laCDET\qhhh $IfgdfkdЖ$$IflF8" p( t0"6    44 la\]^muqhhh $Ifgdfkdx$$IflF8" p( t0"6    44 lauv~ͷշqhhh $Ifgdfkd $$IflF8" p( t0"6    44 laշַ׷qhhh $IfgdfkdȘ$$IflF8" p( t0"6    44 laqhhh $Ifgdfkdp$$IflF8" p( t0"6    44 la  qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la !)GOqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laOPQ`hqhhh $Ifgdfkdh$$IflF8" p( t0"6    44 lahijyqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd`$$IflF8" p( t0"6    44 laиظqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laظٸڸqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la qhhh $IfgdfkdX$$IflF8" p( t0"6    44 la #qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la#$,AIqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laIJKZbqhhh $IfgdfkdP$$IflF8" p( t0"6    44 laJKYZbcds{|}йѹҹ #$%4>?VW_`|ɺʺԺպֺ "#-./=>HIJYcdhBchf>*B*CJhphhVhfCJhhfhVhf>*B*CJhphhJQ hfCJhJQ hfCJhKbcds{qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la{|}qhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $IfgdfkdH$$IflF8" p( t0"6    44 laƹйqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laйѹҹqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd@$$IflF8" p( t0"6    44 la #qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la#$%4>qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la>?GW_qhhh $Ifgdfkd8$$IflF8" p( t0"6    44 la_`j|qhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laʺԺqhhh $Ifgdfkd0$$IflF8" p( t0"6    44 laԺպֺqhhh $Ifgdfkdة$$IflF8" p( t0"6    44 la qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la #-qhhh $Ifgdfkd($$IflF8" p( t0"6    44 la-./>Hqhhh $IfgdfkdЫ$$IflF8" p( t0"6    44 laHIJYcqhhh $Ifgdfkdx$$IflF8" p( t0"6    44 lacdn}qhhh $Ifgdfkd $$IflF8" p( t0"6    44 ladn}=>HIJXYcdet~ȼɼӼԼռ $%½ʽ˽̽ڽ۽ -./=>HIJYcd|}hfhBchf>*B*CJhphhJQ hfCJhJQ hfCJhUqhhh $Ifgdfkdȭ$$IflF8" p( t0"6    44 la˻qhhh $Ifgdfkdp$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la%>Hqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laHIJYcqhhh $Ifgdfkdh$$IflF8" p( t0"6    44 lacdet~qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la~ɼӼqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laӼԼռqhhh $Ifgdfkd`$$IflF8" p( t0"6    44 la qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la $qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la$%/qhhh $IfgdfkdX$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la½ʽqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laʽ˽̽۽qhhh $IfgdfkdP$$IflF8" p( t0"6    44 la qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la #-qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la-./>Hqhhh $IfgdfkdH$$IflF8" p( t0"6    44 laHIJYcqhhh $Ifgdfkd$$IflF8" p( t0"6    44 lacdn}qhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd@$$IflF8" p( t0"6    44 la˾̾;۾ܾ!"#2<=RS]^_mnxyzÿĿοϿп޿߿ #$=>?LOص hBchf0J>*B*CJph#hBchf0J>*B*CJhphhJQ hfCJhJQ hfCJhhfhBchf>*B*CJhphC˾qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la˾̾;ܾqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd8$$IflF8" p( t0"6    44 la!qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la!"#2<qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la<=GS]qhhh $Ifgdfkd0$$IflF8" p( t0"6    44 la]^_nxqhhh $Ifgdfkdؾ$$IflF8" p( t0"6    44 laxyzqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd($$IflF8" p( t0"6    44 laĿοqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laοϿп߿qhhh $Ifgdfkdx$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd $$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la $:>qhhh $Ifgdfkdp$$IflF8" p( t0"6    44 la>?@LPqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laOPQ^abcpstvLM]efv~(KLefno$%DLMltuhJQ hf6CJh(hf^J hWZhf hBchf0J>*B*CJphhJQ hfCJhfhBchf>*B*CJphIPQR^bqhhh $Ifgdfkd$$IflF8" p( t0"6    44 labcdptqhhh $Ifgdfkdh$$IflF8" p( t0"6    44 latuvqlcZZ $Ifgdf $IfgdI&gdI&kd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd`$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la!DLqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laLMN]eqhhh $IfgdfkdX$$IflF8" p( t0"6    44 laefgv~qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la~qhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $IfgdfkdP$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laCKqhhh $IfgdfkdH$$IflF8" p( t0"6    44 laKLMfnqhhh $Ifgdfkd$$IflF8" p( t0"6    44 lanopqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd@$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la$qhhh $Ifgdfkd8$$IflF8" p( t0"6    44 la$%&DLqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laLMNltqhhh $Ifgdfkd$$IflF8" p( t0"6    44 latuvqhhh $Ifgdfkd0$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la 6>?_ghZ[z@HIltu$%IQRv~'/0S[\@AhBchf>*B*CJphhJQ hfCJhfZ qhhh $Ifgdfkd($$IflF8" p( t0"6    44 la6>qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la>?@_gqhhh $Ifgdfkdx$$IflF8" p( t0"6    44 laghiqhhh $Ifgdfkd $$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkdp$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laRZqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laZ[\zqhhh $Ifgdfkdh$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd`$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la@Hqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laHIJltqhhh $IfgdfkdX$$IflF8" p( t0"6    44 latuvqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $IfgdfkdP$$IflF8" p( t0"6    44 la$qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la$%&IQqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laQRSv~qhhh $IfgdfkdH$$IflF8" p( t0"6    44 la~qhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd@$$IflF8" p( t0"6    44 la'/qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la/01S[qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la[\bqhhh $Ifgdfkd8$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la8@qhhh $Ifgdfkd0$$IflF8" p( t0"6    44 la@ABQYqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laAQYZ12BJK[cd >?OWXPQaijz$%?GHfno ;CDgop hJQ hfCJmH nH sH tH hfhBchf>*B*CJphhJQ hfCJSYZbqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd($$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la)1qhhh $Ifgdfkdx$$IflF8" p( t0"6    44 la123BJqhhh $Ifgdfkd $$IflF8" p( t0"6    44 laJKL[cqhhh $Ifgdfkd$$IflF8" p( t0"6    44 lacdlqhhh $Ifgdfkdp$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la qhhh $Ifgdfkdh$$IflF8" p( t0"6    44 la 6>qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la>?@OWqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laWX`|qhhh $Ifgdfkd`$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $IfgdfkdX$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la%HPqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laPQRaiqhhh $IfgdfkdP$$IflF8" p( t0"6    44 laijkzqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la$qhhh $IfgdfkdH$$IflF8" p( t0"6    44 la$%&?Gqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laGHIfnqhhh $Ifgdfkd$$IflF8" p( t0"6    44 lanopqhhh $Ifgdfkd@$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd8$$IflF8" p( t0"6    44 la !;Cqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laCDEgoqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laopqqhhh $Ifgdfkd0$$IflF8" p( t0"6    44 la 9ABltu;<PXY67#$GMNouv .45S hJQ hfCJmH nH sH tH hfhBchf>*B*CJphhJQ hfCJRqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 la qhhh $Ifgdfkd($$IflF8" p( t0"6    44 la9Aqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laABCltqhhh $Ifgdfkdx$$IflF8" p( t0"6    44 latuvqhhh $Ifgdfkd $$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkdp$$IflF8" p( t0"6    44 la3;qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la;<=PXqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laXYaqhhh $Ifgdfkdh$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd`$$IflF8" p( t0"6    44 la '6qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la67=~qhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $IfgdfkdX$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd $$IflF8" p( t0"6    44 laqhhh $Ifgdfkd $$IflF8" p( t0"6    44 la#qhhh $IfgdfkdP $$IflF8" p( t0"6    44 la#$%GMqhhh $Ifgdfkd $$IflF8" p( t0"6    44 laMNOouqhhh $Ifgdfkd $$IflF8" p( t0"6    44 lauvwqhhh $IfgdfkdH $$IflF8" p( t0"6    44 laqhhh $Ifgdfkd $$IflF8" p( t0"6    44 laqhhh $Ifgdfkd $$IflF8" p( t0"6    44 la qhhh $Ifgdfkd@$$IflF8" p( t0"6    44 la .4qhhh $Ifgdfkd$$IflF8" p( t0"6    44 la456SYqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laSXYZz{kltu\+/J h9CJ hQ}CJ heKCJ hV#(CJ h<.eCJ h%1CJ hCJ h5 h5CJhXh5\h2D2hmH sH h<.emH sH hJQ hfCJhfhBchf>*B*CJph hBchf0J>*B*CJph2YZ^uzqhhh $Ifgdfkd8$$IflF8" p( t0"6    44 laz{|qhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd$$IflF8" p( t0"6    44 laqhhh $Ifgdfkd0$$IflF8" p( t0"6    44 laqkkee\\\ $Ifgd? $gdI& $gdI&kd$$IflF8" p( t0"6    44 laSFF90 $Ifgd? & F$Ifgd? & F$Ifgd?kd$$IfFF3f1"y3 0w"    4 Fap#5GXkl,-;IWetu $Ifgd?'r>K2c $IfgdQ} $IfgdeK $IfgdV#( $Ifgd<.e $Ifgd?2ceo#$^_`mu 45{|}Լ¶ߧߠԚԚhmH sH  h9CJ h%15CJ h95CJhQ}h%1 hS+CJ hx+CJ heKCJ h=eCJ h<.eCJ hCJ h5 h5CJhXh5\h hQ}CJ h%1CJ9cdeow|xrrggg $$IfgdI& $gdI&kd$$IfFnF3f1"y30w"    4 FaSHHH $$IfgdI&kd5$$IfFF&f7"l@  0}"    4 Fapxmmm $$IfgdI&kd5$$IfFF&f7"l@ 0}"    4 Fa #xmmm $$IfgdI&kd$$IfFF&f7"l@ 0}"    4 Fa#$)A^xmbb $$IfgdS $$IfgdI&kd$$IfFF&f7"l@ 0}"    4 Fa^_`muxrri`i $Ifgd9 $Ifgd? $gdI&kdT$$IfFF&f7"l@ 0}"    4 FaSJJA $Ifgd9 $Ifgd?kd $$IfFF&f:"l@  0"    4 Fapxoof $Ifgd9 $Ifgd?kd $$IfFF&f:"l@ 0"    4 Fa4xooo $Ifgd,kd$$IfFF&f:"l@ 0"    4 Fa45:R{ulaa $$IfgdS $Ifgd?kds$$IfFF&f:"l@ 0"    4 FaytQ}{|}xrlaaa $$IfgdI& $gdI& $gdI&kd.$$IfFF&f:"l@ 0"    4 FaSHHH $$IfgdI&kd$$IfFF(fI"n>  0"    4 Fap !'(*+,./01289;<=?пʻʳпʻzozh[h1s0J)CJjh[h1s0J)CJUh1sCJmHsHhQ}CJmHsHh[h1sCJmHsHh[h1sCJh1smHsHh1sh@70J)mHnHu h1s0J)jh1s0J)UhSjhSUh, h,CJ hQ}CJh hCJ*xmmm $$IfgdI&kd$$IfFF(fI"n> 0"    4 Fa ,xrppppppppg&`#$ $gdI&kd$$IfFF(fI"n> 0"    4 Fa ,-./01=>? $gdI&gd=>  9r (gd1s n@$ n@h]ha$gd[  n@h]hgd;gd-eh]h&`#$&`#$ҭҡhhWjMh1sU1j7O h1sCJOJQJUVmH nH sH tH jh1sUhSh1sh[h1sCJmHsHjh[h1s0J)CJUhQ}0J)CJmHnHu M 000P&P 1F/R :p*. A!3"#$% DpD 00P&P 1F/R :p*. A!3"C#$% D 00P&P 1F/R :p*. A!3"#$% D 00P&P 1F/R :p*. A!3"f#$% `!]߿p|֢r1`ER4x] pTu>ow%8dI "CГwYc@#jŸ Xf"eZ'qRJgJkgi܌]ĆNm&f&!!a 1]],Zv5+=w9スo$WZl) ?+4XbXR ea3!lsȉ "8e19-8ɯ3rX"^Bp{_.  i@@qwX%_=Ysvy'Y2:m?W>utԕ9cv OEpx|JuJ06wO2n#6IA)焎 nG}/mN0T12lϹÔCnsG8s詃22Qʄe/GAoҫA,]ƿ˫'ZGVm6r42G&3^H7hm@qZ+sAs5?'D4~ dDwg'?<{~hǣqu\Ŷ6@'2$P(s,9O`$Y̛ Iq/eW6th\7H(s)5wXu" h X_6⮦uĥOrEg/W<lz2@d@Iu"d߬~.z6J\6Q)f M| <-'O },%>b-ԞSV.=5/puʥE5?-MUu|pu|#!n"Nk(20mq2|}Ut틚mnySOgcPXJ!'Ő6P H/ B^wv$UbsTcDZ :Dߏx+6kRdH^zY;|@Z@_=5~nJ`·!WD?7̻ybu>A*|/5ͨ/yFR Mߞc \|\擧TwϷǯG,=~]^]=vֲ qbG_-q3/s.?šVc>ֶ)įc9g<0ՙ8|K 5}'N3,B$41l*l~lE²X*ID넆@tƧwݸ?rƵSG?Άz "?9F1탩dJg/nL7u}Y{]owecuXS\ %@Аݸw2C$+LjcY/<Ձ\_&E}x~' 0 Pw?++t`g߰y:e·#z*7MkEz|po_,'}h|>y_d|?y+j`܏Ecd׮/{l|f|}}e'@Km1퀩&xQS72Mkae^A}VcƬԽ7hglhVD_TВS|% 0=o;ߕB9ʶlk2wLP3%td=lJE#g)S8<iY >gzi /2vw<{<5Ǵ$'W0߄Sy}6T#HPD|\L܇"T?.$=7!s~82hCF,? qDeG mb AaeȮԽELoG(3|6}|~DG^ʳot}uL mﷁO;_9qYl:|ŦwF=5@$69Lۼ.4os}>~yŦ[ٴc9Q)uV@7Sik=Lkdя~D=j/%>?&p_5}.9,`i5WF5[MTFȶfcr`ۏa8CÀ7g|p do{9qt3w=wvFOW =vs_ z ׮Ĺ?3?9 ~Kܼ"3w46-i~IT N`q; uBqh{;{̢ྗqXL-s9Ws%ɾQs8,Os87y;xdcF7Mu:}ۡ˃b7ߐP&x.hlй7_sKV:;^1.8W˽߯M qod_eyv MN ۼޝam}Um_AϳG7#D(wb(r^Rb7ߝpJԽ nzwb9OR{^vs,M}!Y yg:Lޛq}>1q&M]{c8m؟w5{w .V:ޝk8f߅= 4Rvs+޳8=ٵ4Σ.9VE4G,v|lc!¹m4o +a 6`wj7AW ~Ε̣o*'9?:L=Cs'T{k<ɔ3}1u_f{[̺LzQbᄒOps|LݜGzZe(=S'St9S{cH;8~qyH~T:ޡ؍q( 0瓐7=1׾xQS72Mkae^Ǟw_ps|LݜGQ?0g鹟]T.%Ouo`/>gU )OچK{!sݛz:mu}1u.3Խf]u}|T/Qcu2"#->Q]F癏zFQ1ç901lD(~EOs>x7}hU|[M|7^ M)r;^#HjODlgUs]H!PZ[AfͰޢ rL]sbx'W ϞnC 爓nN$T6GsO~Y?9┅2E4s|[.](O+C'x;&Vh\܃49etZ4 ز[ĉW[B'嘂:t)')~-Wb!ޑJ-Vڌ;s4.<͟nNMlr% eF{[ׯ(uSARXTgUa>RLe)Q={}dcKxsx}ֵhG6ϕA\d.|/=m{& 8ʊ3DXjD8*ɏ&w4薇Բy3lgL(7_z5%S,]tf23H/UCnpҖۺpV~y^Юjn1;zPAyBAsPVUxJg}W맰8?߹H1/+|zPSݯ'[ȧdX~EȟûPUzeg uUKPϵf*}U I=Uj̰Z PgA߅2wYA7ma0!(}q{b&o<^5[lشz)˅ fO9ZCo|.KtlZr6OՋYo=hk-;7߼a:>G OY?xx0kr??gWOX_eϫceݶW,C3y}DyK _Toc255322944}DyK _Toc255322944}DyK _Toc255322945}DyK _Toc255322945}DyK _Toc255322946}DyK _Toc255322946}DyK _Toc255322947}DyK _Toc255322947}DyK _Toc255322948}DyK _Toc255322948}DyK _Toc255322949}DyK _Toc255322949}DyK _Toc255322950}DyK _Toc255322950}DyK _Toc255322951}DyK _Toc255322951}DyK _Toc255322952}DyK _Toc255322952}DyK _Toc255322953}DyK _Toc255322953}DyK _Toc255322954}DyK _Toc255322954}DyK _Toc255322955}DyK _Toc255322955}DyK _Toc255322956}DyK _Toc255322956}DyK _Toc255322957}DyK _Toc255322957}DyK _Toc255322958}DyK _Toc255322958}DyK _Toc255322959}DyK _Toc255322959}DyK _Toc255322960}DyK _Toc255322960}DyK _Toc255322961}DyK _Toc255322961}DyK _Toc255322962}DyK _Toc255322962}DyK _Toc255322963}DyK _Toc255322963}DyK _Toc255322964}DyK _Toc255322964}DyK _Toc255322965}DyK _Toc255322965}DyK _Toc255322966}DyK _Toc255322966}DyK _Toc255322967}DyK _Toc255322967}DyK _Toc255322968}DyK _Toc255322968}DyK _Toc255322969}DyK _Toc255322969}DyK _Toc255322970}DyK _Toc255322970}DyK _Toc255322971}DyK _Toc255322971}DyK _Toc255322972}DyK _Toc255322972}DyK _Toc255322973}DyK _Toc255322973}DyK _Toc255322974}DyK _Toc255322974}DyK _Toc255322975}DyK _Toc255322975}DyK _Toc255322976}DyK _Toc255322976}DyK _Toc255322977}DyK _Toc255322977}DyK _Toc255322978}DyK _Toc255322978}DyK _Toc255322979}DyK _Toc255322979}DyK _Toc255322980}DyK _Toc255322980}DyK _Toc255322981}DyK _Toc255322981}DyK _Toc255322982}DyK _Toc255322982}DyK _Toc255322983}DyK _Toc255322983}DyK _Toc255322984}DyK _Toc255322984}DyK _Toc255322985}DyK _Toc255322985}DyK _Toc255322986}DyK _Toc255322986}DyK _Toc255322987}DyK _Toc255322987}DyK _Toc255322988}DyK _Toc255322988}DyK _Toc255322989}DyK _Toc255322989}DyK _Toc255322990}DyK _Toc255322990}DyK _Toc255322991}DyK _Toc255322991}DyK _Toc255322992}DyK _Toc255322992}DyK _Toc255322993}DyK _Toc255322993}DyK _Toc255322994}DyK _Toc255322994%DyK yK http://esubmission.ema.europa.eu/doc/eCTD Guidance Document 1.0 FINAL FOR PUBLICATION.pdfDyK yK http://ec.europa.eu/enterprise/sectors/pharmaceuticals/documents/eudralex/index_en.htmDyK yK `http://esubmission.ema.europa.eu/doc/index.htmlDyK _Annex_2_ExampleDyK yK phttp://www.ich.org/MediaServer.jser?@_ID=554&@_MODE=GLB+DyK yK http://ec.europa.eu/enterprise/sectors/pharmaceuticals/documents/eudralex/vol-2/index_en.htm+DyK yK http://ec.europa.eu/enterprise/sectors/pharmaceuticals/documents/eudralex/vol-2/index_en.htmDyK yK 6http://www.hma.eu/277.htmlMDyK yK http://ec.europa.eu/enterprise/sectors/pharmaceuticals/files/eudralex/vol-2/b/ectd_01-20006/ectdpaperv1.0.pdfyDyK  _1._GeneralDyK yK phttp://estri.ich.org/eCTD/eCTD_Specification_v3_2_2.pdfDyK yK 6http://www.hma.eu/277.htmlN6DdK<  XgtcA?Bild 1C"b^5s -SP%+D:5<z n25s -SP%+DPNG  IHDR1csRGBIDATx^`?  'ꁵk~?{zmJzUöZ*գZ`"@@H!@ $&{of7Mi\f?1I^G˾tnr8d;LmQǷ.,׭^IJ۲Zr?,s}/gY߹u׉jtjbe']q_'BJu|L7ryԄv{Zu7\:Xlz]fǐ1!jPʑ->1e-*9!>C FgqvؑVq{cAxC[ ,qKPqПPLG!r_n߿.P  oy37~оwwVI`6nmCkau3QnP>`?D⛹sEM{^mPJBX?,KcgboؖX:w~&Z}LC4h?>!߰31vVZBzo>DFs;'AZsʒ?iI   @B mڟ_Hcgqk׬jۃq7?h_:.1lw_B)Zo4:g-o.,줮" ,1 ۋձVgWzJǣ4F;X^΅55-Y9{v[o,e6i–:|Ѿ߇970KMw.[-hY:ʳLr$"iBoegqB eo!3Q97szϊb;N k ZK_,QZ~ϷronXB&~cgwgׯ_V@/~Ug[Q׺%N_MOLJ)`o;_B"E|?9X?`(|xpAC6YAg0g?-.0-'d"iuON~n}ٽO+6}Rs+lgg;A@@H~mV;~ &JmÇ2)ʨ,P];]{{*++w8t2Ko~_MOe`s%?UoI'@fD@@ڐدs?rdB"xd+JNiS)n---ߩ蟖9Ц]^I0:WrO2۬b   =Ip=5mYpUU%S8eף(jۡ#ʙzBȑ#YY)I@@@ V;VqR3 nXʵB/;lK}#/TbYmu؎iæRilLm]h w=? 5S;.0uVGf#ofl;/exiṺ,ynq[m(AG3}>&A? /rR*kQ8g|A,m;GP?-~VSSu0Gr m;F6x%._\AZ Qp k"k FZg|*Y9h#Smkw{6ԯ s{jwQjl8n]y aW__I}W3ng8¯v ֌~8t atgb*b`?-aCv_ X@@@ Ցxw(J1~wﯾ=yv? "G$   @ ڪd84E[C? /݌La@@zDufk}0gf)mUp ;uܴ !Jw؈;qZ=;7/TQ86I\K4xm"^tR,VX(%=  ..rV:Ӄ4>;u#e(iYi}gFzzxD8ɟ j9`_h׎1 Go釔 m9nfE&P5X>qm3k>ηpi4o5   cjh?kOqծ>rmàZ,s0K",:-qTegŵaaFO?ÀQC 2jF 3$ވuF쾾mqǼwz?SKCKX@@^"mIn~}י%+=HOڿ(8&W2ϛ~ِvpçPiN[Q%mlVkW`Ռ ߜ05| e5   ִ nWڎ5;tveβۮA嵍sOz yl-( چLb)X*+nd URD'NWwڎ[tPiXVA@@' =ɖ{;+l}ڭzg5hw/rQ/yktsGR=Kv9Kb;cVߝPA3^vf0ayH~޸piOC8v-ZU#  @\fWݟdgjzdx,e@rf{7SVٺXשl{jV_ϋ/1fu×l68b=wӪw_\+bo=Z3 _UgCS4`>K?mN@@zƶ@߯d)9}Y㇟q~N7aXΊLI@@@@ +;OsCӸVdfɻ{6-aJOI@@@F #3sGLh5yho8Z##  sA{@g   @ ㈺%v$y   ,>\ص9XD {`!G@)Hڃ6aJ)8eE  jp,E\=ږ;++{95vU]j{W/uwMWl@@N HT8Y9rp=k"@@:t1H:uǩgW~ѫ&G{`múf`gV='ܳ;v'<^owus xp?{t[B@@ %>|_hFܡWwwe1{E'?kNw醼.**;v1cqiIV=.i{?Nqޱk@qN2}7^CL?vٙ'=lKwR3  1 _>u[n?L.uf,S}zј _f_ͮ%i>v4Zv|T<Ȗѭyycg i*рO?4pͳW?ۓ=0knb \܉ش^;I3&=7,+O⢁3n÷>?646)N^3qܨ|9VTMJaHL9Y6jm qUGmWG):>l٭i5Mv Zi*#Y@@"uS?K\dẖuç\~ߌA۷_F_-6K/MO0֧O P -'??\qj+_ ]={Ę{{nϙ?=4`6jS\Ur*>QiP&L8dZ)нozHlGcYʀʐ1ϒ@@@  -u-N8tMsK nZ0 a8Ҵ=q2DZBCUNEү:ޫԷo#FH8q!ggg￧ĵJ9x!܁Y~% g6UT?|3-JS[F>eYcJ]S R Q UT\}E'txe+#J?+OS3&f$)1ۙ[7=R|?7 @@uSsOPy>wZ@]=ək+WnWgm~˪YTd~6dUZ}m @@H9(~En8?n?<#M}K wsݟTE[h{G-΂VrU Q\9p+mC'N0d`#_u Z{.JK|Y(kO~SѥɭGG&5Zm9\+W 2߯=gy޶4'm]4U4\_ŗ.f7{5~sݙ[Cٖz^t; œ -MjkY5NeOxۂGdf_Qg&@@(ߡf)YӐ~9?ϹHnΟH~a]|}3jjֆ -OmPѲ=NKr=|EI BkXd>ɑTǡf\^#e}r#j*9+3%5hR(Xfy!KZMR>sԠ%R0ӯJQNOeU_V?hm59C2v3B΋jÌ_c|qD1dWfn'x}r{pfB@@"K鬀AW-;`iMҨ'9OѵD$4 {̓1PU:nvkrY9ɽچ7eYE=ZΝsl~ l( ["ak^^Z{KMk+eK[-Ss2rVuΤe(2+dWeXީq gak\X̿0)ڊ;1tr㠱3>P26*{G//aRVhQ˫:˵Ԛmv7-^<]Gد:[M̻+꬟m@@HrhP/oЭi>maNDABC@aiOh}rrrˀeujK7ho-]TRC(gӕ:IU#>ٮ\y*en0:z3`@&[>K8ӇIyVn3WmS=7`ou:(Yhկ`\WeWJ/䫚L%k4BG^??i+ o.c2Y|7^-OAmG@@  jijÿx9}) yiEVLe6/@MOK:Ϟ=[ڧG:<\۷oojjRGIj+_%,El+&P?$gUR_5U Y^Xm>r[O]o<r܄J8P#֬/`o-=r@qxSr_9y< /{co{KcUf205WuF?SZ_2ZΟ? 76s78wWFVe_}ثn u BT  $@5Z xYN'%ׁTh %,b?&߄/铫QͿjȑ#~nHMRL7= l'J1_[q9]uM/xx/_ ~weddo<H G e虲ySƣumA׀zt; o+gcl wOrdnXMGU~vu2/#E٩('JܝL勮#+Qd{%W%_˜{ :?=C,Rn (Mk]x-M7o!Q@@"*,~%?ۮq>yL{qx7>H.mz>>6sf5 GUԷ%?OnMR:Iʕ_B_I۶mQb>}mp0?Öw_ܸܻk1u0{V;Y N֒?zNG69Iumng~yezKYƭexfǯοrXi;r%1gvVFmsI6Z  (k/rbM{}ζFY7Og< {d`G.)hΖO|7MYh Ӯ5\-KkK? vV:O~%444.}o53?Oim?~ݛ6U}h9>oUFM4`=gjZ dQv>G$wIwQ#-ӯQmaITף^ ufמ`NAo*/K~%{}fgǡF j,Wz%WG}%jZ6/\+=cSj?H~.yY@@G D9klkrramaޏך3p ;8&22,@;4a f]re̙3Yڋ!Cc~3,Ʒ=^g_T<8?(1psoio_1M{wx2l}X=i Myva;$_ƨ.٧ppڠl>OW qb쓊\,la_6gM5gQ_rmY,huW[#vt`?yMkΥW:ZWX杯/֮m]u~-@@z@txxN7GmcVɷV2[X~ϖ/7ysNS$7W{3+uwRc64~3rڳ:+g>o,RI/ϔ%u[MY?7YȄf,6f_h]Pഽӕ;Oh<;+F_A:q.{,tYNۧrpCç3~E52'6x;_im}鷿^j;w?RMkWWTnG9D?&(  @O.KϿ[s{wSu+#+~%:g޺d_Fm8^2`_kDh[K]OʏdUnnNθ1555---jUO>n^.ig݈!WfO[W;VGzճ՛]Ed5ʏn~IsS/'7Ыe`fWB}ޯ%Ň*h9ͬW)rPz_mդO*?|gmr㫬ț[ywpǎ3G*vԍ5j˳%Jwڿdޘ9߃O;4')6mMgTn{o7 w_])+x~p8áT2ҔsKbIL n+D@@ 8-[&U/nT3WP~z_Aށdȯ~ow[orQOʍԊشivokn   t8:*X D ؼ.=HPT?"  )Р ajz:&@@H@,'?'h3T   @ \ t7    5>)A[&(   ǔp/If{Q #  $N֭C]<0hzzzM3d<]_wĵֲfKQʗnhS뻫l@@Q~X‹F5;sַ;Nwyizsw]iC_]=GXX ,- [@@@" #v0רZ_;h@O)2n踱C|ɠK.pɨAF ^<` W033oɠq\C%C   r2qߩ3-gӳҳ2222կ#V'p>"[2ׄ;e:[b3S9Ғ`G@@%mj46yZZ[dv嫫uӸ/x^qZZ$ K6*Nz̶bPp|o鋷θs۬v\yWYJ!  yz6{]^WzY ^u=n▫m33mI枝d9I8;b(+y*n}ɉoxݏFhڥeXvGM_xVn/&k   %o_56{ׯ% ξ]UjɏoxӼi޶4)a qÌjYF]knZ0V-W7(ӵqy?Xp"nhhq;[;oYZ(j=- kew×{   -ATêGN~]tK/꯭^W7\~CGUmhF-;EHsGfkfz&`}=: SY)K|>_UUd@^X >? 헷)I1@@@Q~y%Bߑ)ڳn`iCoL *v.?-XjV-QٜB?J[FD\Y1:c=  tbW^_ₗ ^v暙ZmHOX?kjkؐfڌ~Z+~\ l5k8&Q@@@ د,gAÐGrpJ?HMS|[, NEkVG[╛Ex,[ؼ1~\ տ]688`K6.KʨQ9텸yk   `yyHcp?kUo.SAF؟os^vfȩxj|~[^l=Oݰ#ZiU *U7җ7| U@@@nsӏo]cW6g#)>o 8VlyaDN֟mg;r.1_gݺu2>v?տ}^x_oV>>xMw_Y8tPC5?z]m_C -..C  $N@lK[KKkKk[K0 go+~+޶mZe3|`_ٙwܼ64A˭vwJkw{_ZZ:ԘkF1"  $ܳmqy\2'bMz=Rm˖-[tiŮb:aJX_ E,[֯_/ {\թw 3JZf  l6X/S5-W| O?Ul3Ť|;` IpgǺ   g Ëǿ5j223#MIs]3҃SZZkZ>&ǻ82ox#Q5-p+| ;S   #C]^   (N,"  $8vA@@H8Qԋ   T4@@@ QDR/"0q2)KB@@ [{ܤ`_ u!  t#] zIna@@$wWvRGZR&A LJR#  b_Y-1jm )&`8:ZOs@@)r V\ IG|6\ҝ  @#jVgm-S0\ X_?~>yk+vψO6\U=RGV: @ =^ /󟊢QĖT_r5y)Cq_xŗ^̔_4퇇޹mϞ=---h$ # @˖-[tiŮ͆-Yl_ ,5XPkDwHrկa0NRަ#{\1럤g to//_=W޺O_tCR!Ocer[wLr7$I#h +$etπQçPIUQ>k4+huluvս6y#s'gd͟():oEq*sŞϟ_PPAG%  @ ן#pA ,nv_kzn'evIg72TgM_y+'p?4ddVV{ P  q)O@ D_e%ϊJ\9YqHmUڃKuHYBjtԓw52gk?zieW?,gPs:tEBg  8*. #@hym*S$^Wcg7*+os7WH_ܫNgK`:8Syv@z@@" @ [[py7_e'25o7_̤3ﶌïopɗ.-'EV_(J̮]@[fB G# $8w D @M@ \#{'}}؅7{Mv)Y*25YEiVyh$9Uuyfdd+' I/p˗'}Si =_ ÕSJP436?η.Xgȸ-+m?3_EM81-?녅8{N M0;TTx+WMuJu6xgOt:ϸȝf *.T/o޴ƌ ^̄G# ߠ>ryL muzҖ:Qu~vϮK.FѕNJ/vUKCOoOY*϶gm9E63FERIA   `)`oq NH*=z78~8 н>O_2=wz7qĕnͬઓ̓ AoX֓hdRLvr: 0q~}es+o~=OoOI}κ&f9L mJt.̊>%sYأdSҏ(iosh`4Us$gee9O[հk6$y49V;_ 5  @R XP'g̻,׾3Kv7T1Z'_^} \}3!0ePSqݏ=v4j|?+Aӌ~Gj,XȠ? j_U&iQ233z @,=d߃Cߧ_.}_!kڟp_)v.ἬV :n5HOOgɯ;s\kt:mLq_Kc&qJiSzD-pj6Z˼;ڜ3|&DLiLNf@RQ"|{^pXIfEy ~JKҖwտ?s+>;*|}Ν>[eڒG mN4li:|_>ўtT )С>q0t<$*<dఝv*  =R"O*h <2K>EoCu|wLˇTz r%E4F,#|҅_P?.ͶfCG'}  @,r=aF}~猦QFePH2p>},T볫Xc#Y=N0o:'E\enqmrru[@t>B;=f'Ѩ~v)XM17)ԧ&LÔ>h< q\Y6*cKlY>.mmGU@fkuʜW?7Ֆ7{%u ێFpo ГÎ@*s}l0O'Y?RW-5"ZU#*wX)ruMݟ̑fK7NdE!@>vfg{޻dp3Ώan\STTdyzP:ᯀҿkr 3 >}}rj\?5?~yn_lAAAi>P+Q jK.pTцҀTtN"= ݾ h 0fؼC>~yuՅs|K o~[׿~„ re P$ jj8kkI,MM闓#z' Tc8{̮# lc^t%Έ2Wr뭷~׾vu͘1C{TRR2tPNهK->/U|g߹SKvGcu@/` ???r-BBɓnj3h F8H6GF $oC\pөmС7O4 qdIƤ54 @4k?t؁nr.?|(E zbj8I 6_7ސpaіK㩤 p4Jw@e˖-]4}۳gÑqSQ2O8N;[vƄc220TC/_.Ɗ]LRogLZԟ+xݍM ծg_Zߪ3Ckm-g- vK+dh쵻# B;w~oWeQ ]:o,O9Rꚕ?}/Yٙ)dDSpNzع|+|#]Γ ǚ+Az7g2d/"Bp߾}s'XI5g+. 1w"G@ ?o߾gGZa!C(stEz>QN'wUoLnn-:@5V/knji>[ ~[|G ;*j_,w]I2IgI蕳%r+ `F@HjpX~0gM:EI4ͯ8[-Jf]t͟/7*2Nǥw {@ x_;-O9 >WBo06ָ溦5'ZF҇ 8Pm[XX(W2$^gq^r% r@@lt_Cm}.꟥f*ii߯۔FIK3?2k]Յcmk^)C>ᾶV<{MMz=MrnAM'# Sez%6KUGz9wf5Gcl@%@UZ[wʩp*ǛMZNvѩNq\ұ%xSKPM3u6n}[7Ϳۿg?;}tywQQ`,qhLEk@ry}SgUfww@tc/“X~R'uhPX_^[]]hWԪ24\m΃^'N`Ό\S_)W/|aܹSLKV jV89@@ "`}9jI)nu=qt_Z׷_(dža0v OfoEk[$l~W_m"QW oƌ_knᆫj„ F\[=wOڣ['N>3`@J2YZn nfQ5DWUrnJ.MPg  @B~W(quK>Xw+JKv1/8u#mm--A#F5_߾‚CΓu#Xr+   @,)jmm4(|.|h>!}[777X֠uN Kb8Xz6Y"tU8   @ {pl<|l!|>KKS;vT]tbE7ߺضZ$ܓO_@@H@O5jH_}TçϜizwm\:vdnnv{E   Ӯz.`uG_r{ٓ3    t@O9z@]IG@@S #OZ      @o =M?@@@^.@G@@z@Bn% tPoן9sF 46;;qƥ'q8@ blXz7;! $@F%';vѣo'|aĈÆ 5jT߾}/;vlذa۶m^y$R}y^\J_k u+!ټz2@@% $AnJJJ _ַ/~yqûjզP PF^hKB [UF@@@O?t^iχ>x`MM zmiɨoZ;qږ~ԗA   @97+++??_{n)nݺ^z_>~ĉgO\pd>}`Ju djF@@H@0ZpΞ={K?pڵOlkk/ڴk|6 8,mHjo\&L=UEK+ )   @;(--}7r=ps鳻w\QqgV]կ~oY-@@@ t 2do9#Z{<. ;lymlׯwK@Iӭ!P`s=jenuڦ-} k)l8Z l8Y~(ްaW  p,[lҥ֕']5PWuR_WuZ%KtWS.v/_.Ɗ]Y2   `G Nd+#n7oce#GۦMOUw̨Ky"}%%%/**J.eeea=<>Fgef8WT#" \>i%ZCz5Ƕel~k闝ih44,w_ĵ"$@@@Htm\z=y޽V.\HƁdؼ#j^##j5hکּ%KlY7̰VMh.fgl9]q53 l2  ˀ =UUU~P}+b2*%V+W:_bH2e, C 3fؼ&i' "24ٌ %@@@ UR8KUsAKnse5w1;YHyU\ ba2<@6橅ۈmyIU-?oYmyef6S$  $@ 5zr1լxET7ԣwx"_xD7YW  @ .jv\RF'GSaN!7)TtԖ۬'T7mFlr6knv֊aCm   Ѝ)=O/vpؖz,ډZ6, skìP;eZ{¤M…\wc2J+*V͑˃   t@ tm\z=y޽V.\HƁd\dluҧn%js   @$c"!ˀgOe%WWUUVWU'-m&^   1kӐN X-ͳzGh6q~@@@Hl+8(^7X^.lN1amک2   (8mpX N\l].Q2   @oH,B5O{H 'n`{J Y"[0ۛ  cٲeݔk4Xlw\/IXx::Ip}faii%KRȟ~Xk SJ{O)  H}JfQ߼{ꋏx&Nnr7?V~1.mY2̟?(͠N%PVV&Ɠu5Z 9hK=  ()<,{OqUWW*̔[PP _$#ɼwh  @Hk2L[\\<>$eHQR@@y{G     'j@@@K 3=7c˳Wlzf:Ok@@@J 鋷θs۬v\yWa;   @* $].+Vӯԭݟ՞>"xĶ[6:+3Ĺb6k]0t"  hkڧDo&XgQ)|Skj3fH%sII󋊊 D ^eeeao_9ss3<{Ŧg}#^\@@@R;Kx;ͺkǕw~uayy9  @rZ b5*J*Xi#aaaaNNN*Npȣ;Qvw6z6  ;nXy~Jq:uk?C7rY\Em}- MG쩾^wA;   P Zo#C Jsش.OO'ƿ7U\Qj\lvN}amj[$GEa@@Hr ڸz{ {]w\h7448p <,_b 5k(nr$ֲ&fG};oG܏@@@F ̡ggg_l={*+-~TOadx*iyY]P ïka5Re(o\a    LXNuyV-Q[5ߣoǰsd94@@@,1U`Ezr1լ`uƷXTjdž$ըf$TK@@@k7G kͳ2jT3!3qGG s7N7N(  hIQr ;Ǖ*L`-%I]_bg#\VF27F-ohÔѪ쑡Z,T!  #Xlrܹ+ݙwۯHD@@H6JU]]z0Snnel#  $T GE2mqqH!&0r@@@ R;'/-D@@Hp   XW܌-^险r_'@@@U 鋷θs۬v\yW`]   @w $].0+Vӯԭݟ՞>"xt'3FwD@@bH` ɲ@@q?8yŵ:9׬YS[[kA{ݯskv;pF@@RO F1JUƦϿpa~zƧ'=1Ǽ̬犊Us`ΑNz;#  tHqOӵqy?Xp"nhhq0362BY[꺡*8@@@0$c' MWG/=\ \UUeg˦ %jІdu󘳺$t2   )L>JUsY#D0!3qDŽy7qۢf@@@8lsGVmbxo@@@TH14GtrI5*ӕ/Vl@@)tXj,;`|7pZ>)yv-A@@/Xl6koMR   K )^ue=r~6V/>x;m1Zeqnj'g\RR2lB Z20VVA"@@)#'U]]z0SnnnAA|@@ NC@@z@]d&)C    @H=B@@H8AT   \)[b3SN.~Z   U%N_uƝfݵʻwV UA@@RI ~e6Así?9-Zt '#yCK@@@#8(S78tCG<\u#~5kjkk{T>,`{DO@@@TH,VinV6>…\wc2J+*V͑q`DDkmR/4fsa   @W xv6^=r<}+.Z$ 2lf쪦Y5߆r7q t@@@^"9;;[ᵧR|*{TͷmƄZ]WGEMa@@@@ `}.Umfrt^55$Xjs D*#  \ p`Ez]([ZݬZFؾ%@@@R8Gt)V2jT5W]EW6blX0)qa@@@,{v8]m>0/V DL    8-[tV޵F{W2,cUU$RVtɒ%`@x˗ˇbf؄)!  @үiU]W#n7oce#GۦMOUw̨Ky"}%%%/**-(++ɺma*R@@)<,}{\թw 3WYd; @@5/x|Iʐ~{J@@@vLY@@@W {   @H}m*x=p@@%N_uƝfݵʻwV ܻiz  X $].vajUUӀGOœ\@'y  .t#t͓r PO)Nn^q}?p膇,xG5k֚kpTߋ@@@ @`ŒO÷^­ܬ46m| ӓ7>=<>Fgef8WT#kNё   I.8"\0;]W}Oaw?p -qX03~ad@@@*Xj ˀgOe%WWUUqϬnߴa|XD2ǓeƙS@@H@2`5.j2T%*nvkZSiZqTUQ@@@ mv88(^7X^.lY6fksaYwZj@@@@`1[}#Zvz`r@@@z@`yyCjx;   e˖sw}a&O6ڻj?$,cUU$Vtɒ%ꦖU! 0VڬiLR   K Fw`_ٙwܼ64A˭vwJkw{/wkU|ӬI    ]##$Stf͕,_Ɣ #  6RxXz(x|Iʐ~mC@@z@jW   @q'B@@@dH}m*x=p2ڄ   x~/:mq;_]X^^NNa@@@H@]pCV_EY[e?= X}D?,,,ɉiq'r^~}@@D $]dSөW\{# c~͚5$j ͯK@@@ .[RK Jsش.OO'ƿ7U\Qj\f0]3!   ڸz{ {]w\h7448p `Md. D{aݨZEa@@@1k1|VTG/=\ \UUe01^-^K[/.QW˄10VD@@M /9=}.x;m1Zeqnj'g\RR2j?A PVV&Ɠu5a&  M G@qUWW*̔[PP _FE$@R%  &Xvd&)CI@@@ v;!  W_OjC@@HRW܌-^险r_'~Y    H,w36W޽Յd3T  @rZJb5*J*Xi#aaaaNNNJݛ to@@nXy )+oБW1߿f͚Zs C[h~-KIh/]&@@@.[R}'VinV6>…\wc2J+*V͑˃:ZQԯ')BI@@@7GL0;]W}Oaw?p -qXafjI˅ "  $N ps pvvveֳRޒ+ kU6gx8njF@@.d 6O$X4vyV-Q'$3](E@@"fǂ#zb`Y 6   @OHq68`K6.KʨQx;m1Zeqnj'g\RR2D4:@YY|Oh+䠍.   =U]]z0SnnnAA|e#'ޡm  =@ T2mqqH!FKa@@@ $W>v؟W^ʕ믟>}#@@@H,17ٹsW _ڿES7~;ήa   =I )g}k *9?g?{KFF~Ǐ$w   IToyĈ`mk;e]u%s~_}r3e^ߧ֩};vxvvCҏq#V    @ tR{ܬmVڣ~|ΤYY92I5O6;}#AvNJ#  Do_9ss3<{Ŧg9r   Y 鋷θs۬v\yW9@@@zTVӯ9?pn''u?Ekaa;G@@)<|8)+oБW1߿f͚Znj,G@@z@ ` Jsش.OO'ƿ7U\QjwDhur/O:B@@R<;]W}Oaw?p -q &a80\l(i~W]   $)^{*+e竪ꌸDYpP ڻ;κ   @R8KUs'-mfrtT6 4]s83B@@A p`EznVc1񚳴v!ZbpN    HӥX.KʨQ9̤̬Q-ǍCUN6VG@@V  9>z D'H5CG@@cٲeK.K]]\ZzѪK>}uF3JxϺ+)Щh9  @Jiw>sNٿa&gqtֻl@@^E}W|բO_-m>|!sw7wֻl@@^:ZN a~XDܫ#EiJ)eu[ԩSS$Sv2n<;^Vp t8@@^+tteߨo޻'ᅮg!Y={lXg|^aqpD"   >:S!c,'?{S/-_￯1uUݻ+  @j`菘6e_|}d_YO9~s%Z-k}a9ZkqgPF@@@nH,(0:5wg (Rnx{_7q7+BdQճ ks-˛Cr7u6  Bd \fԟ_8JQZ!}. ?%<   @1^y[[>V.Z{ޭ۷$   R;;\|N`wOsM?,;X;/:;DR'   Q  >|xLC9.Wr%kg8_Ha[s<65̐xyp]k ^8  @$W.kΝ|#5g>9O>j0Ws˽0Wn:  )K27y6 ?k7Vp` bT"8UD@HQGZk1l#N@@R o J n]ck  tR7wH# Z@@T8̾G@@7o_9ss3<{Ŧg9r~  ^%N_uƝfݵʻwV {{z  P\,OyK.5_EY[ݟO~~y1I999"5F@@z@k,wd PO)Nn^q}?p膇,xGI ^fMmmmCAKNB-ÊP   @ lQ­ܬ46m| ӓ7>=<>Fgef8WT#k6_ ꤾ%_ KHw%@@@Dtm\z=y޽V.\HƁdCM;%Z*N^N@@@=*kgF6(#[ϞJyKP~Ԗ޲_'%@@@"Уvֱ"Z>WY#t~X1o˹ 8..   Q l`Ezr1լ`uF¹Th?T:@@@" ӥX.KʨQ9dNFD   ='3T͓=Oݰ#] hz֖/?xol@@p,[L۫tF{WeWZj.YWȇbfvWc.  =O u,LMmS_|3wRu۔c5iui3OϒdEEEʇv@YY|Oh Vȱ]{" @8,QqUWW*̔[PP _{K'pZ  Уz5Qɴ#MR,@@@8i C@@H8AT   \3=7c˳WlzfP:Qo@@@ @U[gܹm];{g !R@@pjU< 7~RG#_h2,v    GaSөW\{# c~͚5Q^pD @@@ [)nfi/\eO1o>6:+3Ĺb_5׾%@@@Qӵqy?Xp"nhhq`CՒrIk/2e&@@@D UG^{*+e竪2W-AW&Iڋ(6OQ@@@NXFk6WVzGh F!KQ@@@ (#zV    Ga%g%eԨ̄   <(=Op#ꅾeJ"  D%XlҥKZ']5K1^NkN~_YXZZdɒ^kEcX||+vm֝04zX@@,үiб# n7oce#GۦMOUw̨Ky"}%%%/**S-ePxFV!с  @RqUWW*̔[PP _ҽ[޽=  @8:bɴ#MR,@@@  L   !@N@+@@@,@xʙ۞+6=3U z7      G*w36W޽Յd)  t8 u5*Jm [r?)^?ZvpvQKQ@@@ 0)+oБW1߿f͚(U)(   `_lJp47+MOO.{b;yYY%8ͪ%JV'yms-!  D%@+WϾ0ϻwuʅ8pCCe&@@@ VG^{*+e竪2W ZCQ4   Ebv˨r+Y#Dh,7=AQ@@@ zpf`Ezub`Y Q~hsTS@@@1%g%eԨls"ڄ   pzjx_UUjm<ޫFbp   @4($*n*;BKT6r t{   @(̂#zV    Ga%g%eԨlsW6(  tF=Op#QY-5Q "   8-[tWkȓ% |U'|U' ,,--]dIodϱ ,_\>6kLRke  Fk'`XgQ)|Skj3fH%sII󋊊TKT20@rqt   7F{\թw 3jt`wz  pX2mqqH!F'Ki@@@ S=   @rc? @@@ ޾rflyMLBG8    @ѡJx;ͺkǕw~uayy98:DJ#  !@B]MR¹Oh]:\nwR@@@ (~Jq:uk?C7rY6zu81*   vvΕp47+MOO.{b;yYY%8pU+ 7*. #    `kճ)7wrE2 %⪓,^ee&@@@ UG^{*+e竪2W-)W&5/HQ"   G'Vq mfՏ G "   ۦjRבf-ۯW VsT&(   @kͳ2jTfB@@HpB 'N`(j(   @"˖-[ti"7s']5K1^NkN~_YXZZdɒyzx˗ˇbfmS&~l@@"~M[۹~XgQ)|Skj3fH%sII󋊊:A]eeea=<>Fgef8WT#hMע$   }}tm\z=y޽V.\HƁdP6+Ql    G᧎ggg/6TVWUUeZ諽Pq (   mm*EX+e\Y%*+fz    8 x:r1լ((   @QGtrI5*ۜ E1@@@3(xV/YZX8mr!  e˖-];d~I2+_I}-_IBk5 KKK,YbZ ,_\>6k   H}Wu=sSy+L|Xm4A䲹uŢ=)/@@ $jXyIVVDzݻ%b[^z嗏=q9YO j0oEܢaX8B6,Έ 6g{C`6nL g@@@ @ai…8{_/?\vgW2,Ov͛opFRRwüf8FLg-S,,R  @pDqoFyyy^^\>}8|xٳUG}_CUI5>Ws󈫡e,E-kз͐ ZܲZnNk'}3~    Zҋ88dȐٳg߿[W^yePf26g~]$[#! e,[j3.7Ԡ>݉ysZjD@@bH`֒'g;˕'Oۮ!jj^|wuwr܈W ~mf;vkECw;k9l1j)]/Cݤ   wښvt̯NY?g k/XqOAI0x6`mP5ƥ#FPm3`V- cn@hG@@G 8ʎSրquSĮ[߯KPgA"5ʴߜ2sB@@Hr}q0bS9ߞqѕ?T_/Fa89;wT}|ޯ%jgEC%h(P kWjM7PX+mru} UAC0Tmfmu3Z)<r# @BpTƍӗcg kn /ֿ+WQopgs83$5:ℶ0Mh-  @ $"eee ,]uڹk}tM(,,Xa HtvNVac@@HǏo~#_UIַ hq`8T  ^ )0Da  @Bv@@@P([ƍ5M_@ІPk臦̓aq-sAZ{WMa Ѐvk!  H`V4T{r\ / h   @j t>vѣG~O>dCCÈ# 6jԨ}^z饒7lذm6כZ@@@ y?۷IM7t}t/wn|x~~<(33ĉ999q}[n; Nlϣ>Pԉ˳vT1n;F,+mC@k,$VWW[_w-fݺu//|x5gϞ.(:}t@Ӆ9zly\P6?ܳ"z   "& 8pٳ_?pڵO_h ?m5o;RM_ @@H]4;JKKx<}ݻ?./?pgF.Wz+T3>ikewï*ojml~E}gmEmԣoDa$VQ5>A:   ;-!CfϞ[n3_yAÛ pۜ9W{(wɒllAE%1m!je hAԲ¯~+~\DZPwk6?N6fC@@ Z(էP@v+'O|m]qCF|;X11WkNaxUm=Ǯq \_Učj;|"c:߭D@@ $0`vt̯NY?g k/XqOAI0xCmUXXt'jFzad@tghk!  @HxVv+ܤ/ŗ\'vmݺU~]]] 2pmKS;-C=;7̶" 1-^  /|/}5 ѿ  jٕLj2xIa*+ѿm%B} 36`-s_յ -_=<;v1o=.N\6{''!  `HHJyܸqzLa-9zwJw}7ͅr=p\*ѷ- c[+A&VmmYGQ"V''B:@@~ tD벲 Ю:rꍵ{˾wo:&W{K^F0 h|JAˮԶs{߮d[  NwǏo~#_![>]E{#=~A@@Hܽl$ 'Ɏ  =UO @@@ ( s  D] /<5//oΜ9?Ϯ*qF[oSd4vI`'tm7wq8r.5QLCN2^w鞯xqJ>v!Ϝ{M;^ ֳZ\QiC8ke@@@a,3rQ,8q^;eʔ%UŷzM7$cqd󄞳&=[[F߼pZMAXg #x;咄Cf~3X`&  Z eNZ}rK*ӲEb, əgp h3lTQJގ<{;2 ҅hR   p<=>sLᜧ'\l҅ooڴ&Х+ sRkI8 ˫dY!WpbD$թ  Ǥ`ߞu'h?6pփY99]7uke3ƈ_{5ϑ:VldO'*PRI/z.+@K3~)=m[N/}T=v..t+*xy|+`blGqG@@I+1cx_@[N^NMr}o xժUj s9kP֠Z~։0UwmNE pt=i @@/R|͚5{ڕ6,_OZV'ˀB6"Uj<ԁx ̣8F,@@&pg畽 /)I{ " fH#   0ÃB@@ Sc=G@@@@G pkk={oݺud@@@P'555UUU~#<㏷4`Çڵk7ol"-@@@[ݻK$\poѣG{ Ɛ!#RS^c=)K-&Y-'   p &X^>?{>;G MMMIIIVsϞ՛6}})?HL.ZCٷȵ+k{%ƨ4N(4 V$zE@@ @fE^ouuʕ+׭[sN,[7x7ꛚj;: #Z`mDco>Yqœ䞟/kXrS  ] V pċۿGGg-r 6,Y`hbr8--g+V<WYYY^ե,H~RHf E G  W pHoq̙˗/߱cGzzh ;wرC,\n٠( K=wQ6~g S~r+NP=#mn7KȍDe6 aEyXN/}Kʙܲg*%7ן|پoٻjYyWCd/ ٠ |&4)dƠ @@џ:W644⧤&2뮻3-,,ϠĆbfQ@@pENA >懘" ] i4v+[s/ԫyvk@@@#ؓU7}r)U,ȵYi~Z^^^RRQE#7zx167~w%}h  pgWu-#e+4o1=TSo0HG@@@ ~@[f%>u݀:ᛇg.]4SYl6)1]h@@8Nbr,q/@|sן~^)3_q Onмao{if,\h%:*vdXn VIi@@OXD>^붻4Z]O$]Vioeq&''kZ%=oRefjD$+K   JOJ6;-.ե1[s3mnd6&kyOK%ܙV=6Hz  H pȸNeqFcj>LucκpPVsq[ J__!-]t_ϟ}#N8v'ΐ@@@G z梾1%6gΪmVno%~%k{Vt 4qA4iu)r9CZ[s,/=Pa(R@@@ @ `)Wȿ&)A+5]7=*}Pn,@@x Ht}~q+d(0eҐ|ߟ;,>s+^Ut: Cy&~jȗق\TQn @@@5 *ĂtݮIM(^Xz嚒ؖ@oSԨi k}Ĩ   b쿱j5l6!y]NJKR7lrҚۛB&", ެTgEz 2-Re9Hϴ9ow<_mGf s\(  E&YOǝ9m Vnw:Naؓ;[?[vW¨[\t\^XR9a9yU9}(J)==(儁N)3;;/+I]M.27VU7ߋ*e! i@@ !fEۜV3ЎV8MW)vm45u]=?[5mՈ=_d v֢l!Eu@@@aɚ:MUrjK4Ťi4{_S.af%mR;j-)   MCF 뜺ڄwmhW$dtIݖÇ|٩q#19%%uS"[Ӛ]eArJro@Cp Ke!ۂ\^ga鯁 g voW#  HD1H(.7b҆2eɝlKu.EkY,`7+j.,c aysA5H@3^~_iA> )x^@@@@3O,x,C]ӟ*J4tX̢!#͞xysooIyٯj8M;}'eEX& g(  73 O2&-;gܡL/8ܩSӇ -. 5(0c*d9g,6rKa@@@8/&}dO7:"錋deFҗh5F÷Vl$x) 9*5[X~R<l=y-Y7x ^U BC#  Ǖ{>nwAaRJJ0--m5o6lد`0h_ Ƹ{rT&W   vrak?-5]鶶3 R@@@Hb%_p?Gg?z]_54+θ3" ?׍Ć  T V@8}Y4  >"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "` "  ( VnGM@@@ h@@@@ r;j"  HXEE   HQ@@@@E$*,BE@@P.@܎   * V`*   r`vD@@P P@@@ +&   HU4X   \X5@@@T$@"T@@@$   "ޫp c[{ٽk&W  1+euhR̉Vׁ!>=xUct, 0  )i٫jL>k昅=-kpء&MgG9=D$O>T ,%@@@ *{W1uI%N}IjtY5&FO2z6̨4 ~ e马caV   "9WajMw9;Yԭi0j5fM"l LJEf-u| JS+'ʄ  @v-``nG.#oH=آKh3:~f#L#JdLa6>y9u%9d?  ǘAL&]nnXL4fE`ϩAO&pȊR-llb kO<"E*>XlV.2  J iO0^-[tq.MK8Y:YOK-av:(yJKn-PSRp4ce܂W$U@@8*gA3=tn[&bx{^S+ھ|=%Emf~l?J~&XQ?i[S|]M@@8|gINW}VvKsɆO]{lOfؑs6IWR߻ Vt;/.%-!  S> 1LQxrJ ?\VvP1(Q<|L8G:H~L鸪kUZ絾^Hj~ {I.p\)Y@@@uW:\]3ġ3䔩w5IDATS 4(mTAtCK.X׳zbA^ y!臑hK/Zyd|>Rh@@7i_o\5ndUScٲzӦN(s[5sO&e xZYTy( @@@@].h8#;;!77)--`n=#V : pkz@@@( GI{YΗ۾>xf4m_wKzq#8,:IM!   t s|ʓYګ7~Y8 & I VB?JH   +`qcjS5NY{ Я@ @@@ 0?Dž@@@, pAi@@@ p9.D   eogz꓏=NIn} ;= F @hUPT"o0?"o8lao8Ԉ]د{"e19 p8VQן= v쭘{kOVBhakCϟ??K9GĮR~_NvvMbJk2pC]poa⧟;fD8MQ w[_ מ*`:F.y Q7\!C˯Ng8A1D-G~fnQDssrƶ@E\su Q K|EӼ_סIh6}^}Ac2}0kKg2.v}i81Y{F{uܤ li5Ku@/@Gk֮:i Tk7li}b>ce)PwO:x#_H/sӊ0=%4Vi;wlV[4{6wvv]]fK՚2nȐ'HGs~VFZ}YfPT$rpri\n{ʐxæ"p.[V,mg{ p vf햭8/ V<*iljq8zEոsOP

1ApƭU'XK?d޽p*~-/ڜ>^^}tcOZJ$[VqB^*,uۓ}[x=DK2Fܖ"ٶ򫮷TV^^>x (P0&҂X>7x.):@Gx0~䌌cG:on4xᯫ{wtᗏzI7w'Zjtmq9tșns~vCkÊn:ߵ[~O_"~Nvڵ{nxhw9P8چ0M,6utvvsS^P}Gp %Yoa?]?F)WS~4!EKT<|d2~&Y?xVd[v =%,l7k0[re3NR_TpjxFطʮǷ=E~oƊ%$\:vl.yi߼rlG*j߷zܼozh OWWnq^qޕ͹V]ه(Xg9[U^c|L}o߁0XT:0BuiMMg_{>-fG<.j;FeQUX7Ł&_yzSlac&TbgN6y~/1qOZ7+.-))=gnm}KCc"C-xe[nt}ӵ?>s]}(+>xeSOoxg999yyyYYY))M-_7[&&~;#SV\J>&^ z'NrșNӤh ]Լ$kۑ2૶&q>aMޣAru8"{d+5uv2.]EU}[ 8wUq\11~ވˍ}Ϲwms,>6/o6C՝H?A?lQkTmic}pF&-17]2=s~DV'>+e#jat}?jKN0LMsk24int['O}Ϝ>ߺ䶇mڒS-tM7fl߁ݱ~vce7$_s})sGL|aםyE[{iG=S#*c7'"W]pH8mHHT^UuE 6y22[qo}6@}ok}h8AxذAF l%LnrHw]wݦ#FD333KKKxPa1CԪUk-zP-N .kmCߘ;[Lq U= M=PRZwb+>E|Zu3۾K ]T %L?rsOǦ}%'Ϲmڵ mLmVP̛ O<2u~ =ݖ4b^65nz=1yH+sSSF`+(qT5GYӨՏ:iYs Nm?tƲ::O)9uVYN=r h ug'k?RFϱ.{ՑӮ-[%R/{^07ۆ_cq~ܙ%g/xWNW1G͍~7{+GTpѭ᣷޾`i:-.9ls~_kNK> V46HsF,f7uclX .]vϏ/ϭ[_\ϙ6}~S(lzZ`t[ %xd}٩@v(X&xÖ{Z;m?i+^xYAbyѽB v'd^-]1ߊF.wmJ<#ih54Tշ:;;yzV'6k4 x㣏>w?jV&x0}ߞB`}w-g9_y/wgZ^%,(oX\-,7X6.`@7_hѢ%K\}<=SR+**}Wh~iy L4Ǟ Y An#^N:+w]v˙_r.^њRqsB#!QYA2w'O:ێLI|]jiMqCAyU|NH2O,=*IKOMtF5nGSYx[4fƑ>ovsэYl_FV6!n75"4k޸){[<$N3[9ݶZvs{{{{ vc{bivM,8miM4{¹WxOt]pjzfKow.wlM%&c_Wb5WlشƹgkRR*ͷ>m,_F.jۮr3ٕpk>o$n<̡Mmu[XgxӚΤ4e8<ꂶݍ--QC6XK (m4YSc?gMN{oSF^w+O5!b{ڏy}L`˒ޥ7~tC^ׁ*oj1;󊳳Fj:\Yiq 5LynwXYraL8~lSydzh|hO_Ns~ .E0uԎ֨^v oO啽-:юZtww7W|>ݭwK/^]#&o~wbK=QRv0į[WӦMꫯvA\SSl}CC;h?ݦ||qK :w<_y<s."NkLs^vʓN`#kJ vSv^a5+>Lvפ[ !SdJz}ԭ2H<_y%㹠pZXg-)=Z9邳uz}|NfJjJR|{M(tV˲95"j~kF췼yO6UN~IMmqمcg6e7zfnIʁsN0Z T}|ܼp+_[}&rh0UK۞.ْwﯬܲ۲r!׭&Y+ʇ-crػmuxM{ûoo02FmKmX?2"HS!?HTEnsr1!eS< k YuY)^zO\|po]8Lr=wz=_7Wbge[V:O\yznb,T4v{()IH= nھ-G{X̖WՊ6ٺ]YRtVNq?[g!7+? fCз!_ ^=|'C;W8l 7~aK~l~hwq֧֭)))~ͳ۽O+?sΞ3ƮCU/:!y#f>z⁡e#~tX̬FX C\ZPv0Ċ-׭[w0 pbbԈ3U}༣u^xNR|"ϯζ?gqgþ/{uW{ f^2*/}ĀdmZ|wQRS'* v,~qm鼌ϊ&}Jw0C" {^EZc^gWLӏ\wΤ6sK~I:]jRR||&vܑoJ/?b㡮f/T"~ΰbuZD1K6z)wg#~NlFjS$5V||`AVRb8*7mﴊV~uT)W[CQw>yeIymWoyUvv~Olxn0;%t\ڏK]vh''MNk㧟!>* h'%茗xfNư똶לSxcӲ:7Xl>LR֤sE|cܾշ֬Z~1!!ё?m}XKli!=M2!*K-{%E+[o-1wQ gCYϒԎ,߽׫ޮ IP(;;gЖ-:vnhm?4ȊY4 52uqnn /ۮ+W\yן~I=߿d!ݡiKfghĶwޙ?v`І&miZ:<-5Uބ<WF0{{_}7rϵ"~[R3L8j=1^3]km햴C-$$'n0H;mq+L*[ x/z/IrL4f(툽ĥHL>ܸ7u]VbӔ1qϺ ze{+=sř$8ߍ$G%fn{°qS.EO╩ny{fRF95"jq'w&\H# nK:)Eڬž/X^\T=eղɯo*/ YfɇohYfɛu,v7mym~UnI(ʏKX4Nm~ւ)>/r[5;;>XQku;OU]Jb}a4Z2SJjOxEپהO070=.dнFez3mxe а1H=/{Ҧ Ynڱ́)iq6~ 5=:X[Sq߰c>5k+GhzΖY+7 h?u#F hno6|];Mb>y._ 2#5rW![c!`G^v$5j,w|`V>QFVGLVLN7@C(R8׃%6W^ۡYyO)W=GԆ~ܛ -|كRfڷ"5#=19Y|0d"s=ӡ{])N~1#zJrȁ}uqYG3.rjM跙lpW H' ﹀JONh5.Kd] ':\CW`8L\i#Ig;䕌1M{w9wԹM\Or@Y8Z:RNvp[G$]}nW{MqG`=$&N}ildz5h WTwy7~#w>:g=y <& 4ྺ|]qhhѬ+~ԏtjanFޘ;$,,= kf&2֡!q%Ơ 稿kꪭCr/>esFUSzy<};蓈,1-+Zٯ舼򽲒b3~W Y!VbJ-jY? Vk'↙_,mv8[oؽH>/"B>Wo^]˒KYtt[:'ץ8!ST7cܸNJ׆C hLf@q*mR8Jof򛭇L#r2|znY*PV,&exe}?(R}`L&%'͘6%99)77曯XɓNj涴$'\+pw|._zMȍb2d8?BsO|yKk[,VWlenVTu4NoqOOdJ^=gS\+Y;8Ё"HKvZ f]{GcSkӌ)]8` x`[\lO-wsxJKoِ=ԊFSt׫s^Ƕm6c.5#ȹNGqUƏIܥƥ%憩8ȊۻA`KfFk,CƤg智;>]޿o^$ю߮ܺ8wA^A\&s㧢qCR{\uqnq^wNHHpR[~ gBfXI7wpxn)f^0s料}/dڤ %_oiNi~|wyT(UO.xٙK6,Hʐ2!9 o~[}V)NkC^3!o~U (fIWGW;Z һ 1Z3{xmC۟^~J[g7V,uw/j^ g.cT 薑ވ"=~ё?Y~j[᝷^{zUաۮ칂W<|tH!eÏ7%4<2{^S8f֤9ݞE\=߃~q?y([,l҂Rz?R;'Mgβ]ΖݰSf*m窯Ivu´S}IKXsk&_sfACt4;4{Z4#4exO'WMɰ܄'Mp9M8iL*>e)'.Gz2֑F{<:1YtܑK[c΄aon??8W{֖ul_xRn^\__6=3@KwJ6쯜,/#_?9 y7N`R$--vW_YW\Y\<Ԉs/GsɧKwjii^zEDc^hY>b]jRʠKM9jٓN8񲓯+7>u䤤XgHӿGճ#?B<uCƔ̸[{weKCl|?`JNjv>2Гj9IgN$O]5ƣgC5UYy))ɁYgT,]f99# 8|ί*ŧ=i{]RbJK[sϝ7rO;=NϹ:G\ :"}jRܻw-vώ֧k]پ{<'~EErobn֪?t} c=EdÇ͚9-jGejXl}άV#O6rs' =a``Q g-yxW_y_{eoWݧU7=.9*ݏJz%ٯ(/jIZ٦oy)wϊܯO2&sk)9̋.+tk~Oص>P+"/[}fq~=a7%.7l1 d6`uQ D2,5xwt=𷏠3LemVC=k_lnk5mQ3R?+k?XWؓYiߣ%V̌C&I n%s( .쪭sXZ:Zai4X[*Sr (,9WTb(櫽S//eſ}brJZvAavv4сj666546LfQ7)E|WHz8#;/%5jE$mmM͢Si=mgg*+55-?5Ŕ''twwENmĩ {]N;~vixGnvh2}|7{쪶\&1+=ĉOD52!guR]p>_m7冀zN{?{~:Zӥ[-KuV^%̘[p يn۾hb@z>u)ǣoz}+^ޚSK?cĘdXegθza9ra l8ΜxA-}5'+l? ?W}<>+>Zn%Iz`qO1+nŅJ[ۺ*WY[l2F 4fdiQA" wjػw_}CH}se"IoVVVZZjo?5`MCKkVq}HG{2Q#CiJ`/jKMt:č͢3蛐bfZzj;ĝE]*K-9%%|J"+2$%E ȇurRwULO,K+eWM^5\#,ݝ2@|fpu8L8,7?+@L8kԣ>ثN6Ca+8[S45}{qӟ8s˵"7'yȁK޷gS~9aŲwlkm|G[eF칫gxkdɬӈ\RRR33ssāvAZξN);h~߲_Og&b{#Y-B%6v'D5~X8,(  b@-FNUNn?ъw8"|pw}fa25ϭOYw@*@`:F.y 5 ߛFc@s!$wX]@[cC"&MCC.9$yaPk`nY #"oA^Eykg bܷxF}e=:    J [    A?@G~IENDB`DyK yK ,http://estri.ich.org/DyK yK http://esubmission.ema.europa.eu/doc/EU NeeS validation Criteria v1.0.pdfDyK yK http://esubmission.ema.europa.eu/doc/EU NeeS validation Criteria v1.0.pdfDyK yK 6http://www.hma.eu/277.htmlbDd=LX  C 4Adrives nees 3ba`Y6s-Ίarvz na`Y6s-ΊPNG  IHDR pHYs+tIME ) ,tEXtAuthorH tEXtDescription !# tEXtCopyright:tEXtCreation time5 tEXtSoftware]p: tEXtDisclaimertEXtWarningtEXtSourcetEXtComment̖tEXtTitle'IDATxw|ǟi[I6 (E^iTA@WEP/J("^D+HG:J2kLC~`v9=9s c *Քٳg{1 .wJUv5&''t6hЀ{]l [p4r~_ckԈjU}]_p8Sxk4r͚Q5**UlEQnWffl'I"67-Nk⡨hHq}LIDAT**Ub!bZZzxxDZ4 MK@ 0ƘN':tpTUT*yy!Ta,k4pEn7i@&b5x 5Ԯd8hFqq$IQQQ(ׯ_8+vPw\F_uzzԩSy߷oQ98pp:tj>3`ƍ7s̒%>|M2dY~]IDAT4nܘlA=zرc5 ٿ3g6mZљ%I7o бc:uhڊ^9fϞ=Æ kܸ-[N>c&NlٲR.]3իwѿ#);_M(ߕ|ׯ_ڵ?#:i$ҳݻ_Q  ükRQSXXlٲvM$$$(ȘSf)LP.s]{㏛L4Mze2ud0$IbҥKK.N׼yP_|y޽>(x<߿SN=[;IDAT{N: 8޽{:tv㖃 z>s"P^obbҥK7nLP>sq"10]t_~W)Fz-W_V?*Svh4u V2r$˲((^oCr\RPPðiiW Zj5 /='2"G)y*1MӁ"SV-VZ"[Qb.]X,ud`ڵg}1zK.ׂ%#IDATl`0=ztرz?/$Iz#Gc4ɭ0Lu!#kee1.Y\0@ZAnѣgϞ (  Ƙ˨MHH  0-vTQ,%cl2NG>|R/ODQtFh4 04Ƹ(''W1""jN x,H狊Y~5kȮիWO<>RRQx ==}вΖIDATIIII}8( ǙL&M|W&Ll/njyZB,O/|;~7aaaPYQ|>R瓓5k6q={<z~͚5k׮o4Z-1'rssL2qݻci6L ȲL-f+VׯY&L:l |54MW^ͨPZرcvtNFQebw?N槞zjȑdoDDRijW޾};X,I&ٳ/2 Zj͟?޼yK,iڴlSN||<h0ezb@Yټq:EQcǎ}CBBdY.Yݤl+4͊+/_NLҊf͚_forƌc2rss FjզM'$$™(x||?_TK*fIDAT˫hv]Ǘ;WTTp8dY.(((,,]linȸrz. ֨٬Y ^z1EjأGRSG6mnX TnKE8tƸN:)))m۶5Ld{nnnjjj˖-ϝ;ڰaϓryTa Dlܳg϶oߞ955=yU-{'O?~VԮ]{/..޳g$-[/uaÆhfIDAT͛7R_?Irssrssv ^PNp4LHHWnZ 5j԰ZWm#_m۶vڽE.|/nwFFW a(Izի]N|||ddM2?i&%矯W^nD `23Z]LLLTTh|psT>jJ iVy@PR=QR=QR=G'$oAHbլgwIDATR5]ܿc#E+2P"D sȇFV*WvQQQaa(:5KEc,u}di{Ҏl :|k"M9M;%IѣGcbb$* \۶m;zhxxxYeY%&vk׮III)pUzG*R9Ungz۷쮢IDAT%- ,_oP@C&~Z7Yˁ- 2w+)?a/MF(JE^Y/]4jԨǏ5NM\$7:!FXH,t\0, QE)HMz<[ ~%#rznbXEQheD Q3!͕VJOO:thJJJ `Yc#ux$Ud aL]=4՚) "*,@T߽jIDAT͢mfټy}>dZf駟vi,'''駟sNo!CnZvAIDATmRR7<8%%СC}ϗ 999 .<~xΝVΝ;! M4پ}-[ȁlٲ9b 6ޫ$V_r78.44(W Ieާl/Ruc6kzx 0e0 ]LzMFcXO R@xիWBEEEV5??(!IDAT?pXdʕ+kڤLLNNk֬ 4iҟ**t:uh4eGHs3҇RDc B#0B$I`{141rTn8q8IbbbJETGڅ·IDAToJOj+*BElXv @Q`IT}M<ջkzb0hժUbbW_}uGj믿_"7o޼G客Rܧ^k$40`u817=nvoa@YWv5c쵦O~S (V{}gdYyD%0 j+Qyиrۨ*Փξ`E11ƌ°R.N!JbP<VȱTs;;ro 14IDATy[\(,K5UiWcF>|ڵk: ڷo_%B~R)&3BCheKGbUQɓ$;6ݼyRƊTtqkd=@0Xb?d|"'%a οҹS&hn)9r/^?}tš{՛ \.0`@ǎI>$i۶Q`Vڶm[@IDATvKvQΓiEB_Qf F)i]#DRKۻ$Xnhh(u{nٲ$IbfڵO=߼y3ׯ駃mv1nE ׯ/ݻnΝ;tyU eҮТ$,.gQHL.Ʋ ({ɾoQ!!AӚ;wnllO?n]vf933sǎ#ez|͗.]w^wIDATx䥗^Zp믿>mڴO?߫Vz٣*{(Xu8%7ZJbu1ƌSNaP4@dEhr{2>w0 GKM?7H(*]*UC4Mq̙%  (?|1yZapXrcY,^x؟_Lr͔eYf&㒕$?3aJőc D*Tr{_yGKժUdB AIDAT@aA)eS@˖\ ƈc$#a\~)eSjי3g$+HVσ(BY2/ ` @Q(# 1E0^('e%h #(wt:IF u<|)I"jA\.WHHH.K$uh4v*weY>ydudffr0x'e)J`Lq:@!g@hIV hp9CIDAT={,I;/IR^6mXH6@ztRf;};䧨(ʠAj֬qFx宛r(a맧_|^Y4hPG>(83V[z E݌ɹӴ-7 ,3&.M6-]F'| aaa/2)pB23zh/ˆ#;v,߳gR*wmSds^/Ӳ$iR*dF DIDATT_ڍZ%=;JX-ٷlzaT Eab7#1Z,=: J~A ܈MBaiA97+g-IB-K{+[DPT7;)O`$3u5C^~FU-J;Ck,`Z {Hԩ~E++:,4chN@р"/XXćD4GLdMw?LѬ.1IDAT,**r|ŗ2-hLp|(ͦdoxqK59)4PcoZR TnVRil rh@Z_Gz4鍁'tخexXm\t7nРA$#_AUvePC,} 0$FW0F,#B~Wy5]xylJHx?o_rߵkWϞ==+d>嶅b4} VܼTIDAT%6W=TqzV걯 [#qjj*z۷ԩSnɚy)))TAU-35:%t|\j Bu!9}fmzT]thlܸ#G$I}Y^:u;ܹlm*r( VO, 4B"ȲeKEQLsϭYf޼y.\h4]t~zN@ͬwGQ]0B %IDATe 4\N Ec`n9[`m N|㸀s:NuQ])H2>YQ( DټkD|@6xh4d*mz+V( `?_%?/+ ES) [QQ<r+$D6_DUve`I Y1 @() GY@)kX`(%@ENZzzs=w hڱc޽vVGTeW\#+\/q-fIDAT;HQw av;laTdcwfy 6<**DΘ1l6>|'T ze`svW),t^`YtsˀI2?a(Y(惕mׯϓD>2(InS֕~!`d1ohҤ`U Ͼ5n(qR-U'ВJDUJD}Cl(Jh,lBHLCKTT;]IDATX%(DZK\M Qqܯʮ os\}|DAQudޚ~3JA*dffA/?G$[[{5E=3#FxgN'xGZ ,M2NV3TeW?/|lLqPx\&Gă M<ϟ>}IDAT۷soҤI:nÆ iii&M #%'O,Y-Q]X9h15U\$),!Fc.]p8VZW_QtҒ'Ov:cǎ}ᇫ}Uٕ!Ee ,K>FbjxC @Pw|z ˲d:`0?f{W6mzwWQ} 0(V(ZL8I?(U_zu˖->?UTIDATVTeWB,z:)(8+ꆲ(ah9$@l!(z<2GzZCf͚jժ{p-ZV/TeWjC'}vfA^V@$N䣳0O 6$-J,[~}hZׯOڵkGEEƆΞ=;xwު zeȊv2kG %YA B$B%I[f-;\do9B6`0 BCCiP9IDATlF`0""g[ O>yt_FFX&BVd Ck6ء1Հ{[1v+W3rssEQ)fB"5,_jkCTe!dY& ߲$Ye#&UU*qR=QG;WpQ4 iuq?*~SlW~5&$ &v 3~Eo̻2e oh{(0R$e>]-D &)ZMiIDATq*2xGFѕȇujq'@кmt2b k!amdг * YrE!ԧO'x'Pn[׫i|"+Bh fl*ʚ'eulQmv$K%KHDQԩS_xᅵkΝ;wΝ!!!}IOO/^IDAT|gƍwwZX]Qc+F(0 8/)x=H!,K0hjljh2Z( AAA+Vرc6mmkuC+f٫W{:^ 9i{^I@SʍGy!) -?hvC -xpQʠCktXt2cE`n0VCw35rkWv:݅4g3'*w UٕH>o3t Nh@`¥6ёVc 95?ʮ oa]3cۏ dxes[X 7 kwiK%??;׎VL!E PBfk6m.IDATٰ7HN[nc5nn{ 4xwX+HTeW Ec|C ϧe?O3 ELs)֌1e) B[Q߼,oF֬I$%%}wjӿʸ-&9kl;aX@pcI13昂KYc:vGtho>78{ :ts=t:/^Lܤ222f̘ѪU+'*r(1oN[3>QQsb cPI5IDAT||R޼ysbbc=3MR駟GDD|g]v3f̙3gԗ[x^d@~I++b(~^T]EQL&ӨQFv7|333:uԬY>`Μ9s9x`XXؗ_~9dȐj,#Ypa(e@^b h'!yeY66dͣiI&O>ݻB.K .ܭVVOTeW eB@cPIDAToYD-˳X*r5mt۶mc=֭;{;ՈUٕ1Rd0BAH2/(3, H. c,"y5TEEbLH~HAuTeWS$<# ,%^YeDAi{(,˲mNjKh4_A Q_=~j+$c ӛL#Hɿa{}Zr -v./L8$I)))5jm֬˲gΜ%yIDATnQ Tes\y˒kD"ދ1d-tz]L{]Uٷ@A=wk HG>u]3Z~5j,*Uٷc *hh4:NEUJDSK$HoDMkLFU"ĚK.A_ kkԩQ[}֨ G3F RĬߡZ VUٕ!z!֠>j_ IDAT(tAjj]h ަ(Zwd νFr*C^N!z@1N]`=֬^J5nP+H.tot"Ȗƍ:7AUveP?l# E(iCDclv8qaWbnV/^{]v:ݍD *`iY0P)Ayv?pm޾χҠYEQv'3IDATv(qqq $e˖AAA^q?`Nʮ LŜ_SnΩ2ac-V>&Q!gW^5 }4hoߟ8s…Hh4P]9R<%bfAb6e5l?/73A(,,9r#v1cƌ&i̙ 44h_0aK/tGEP]0B xhd䇲!JZIDAT3 ~g^! TVZ~7>rȵkZjqHMM}~C oꫯ.Y4Z*R0%@ ~8H $^`IּrH&EQ  %VlԩS?p*k h dEQ^xe~IRAɬyǏ_`Aɍ?C+#E i(- Rq`QXF0 9yA\.|OIDAT7o^`lgKʮ Vc҄=lsd{ylqd`` 6yY&@Jk?Zm !!{dĺcǎ5jxG?~{ze(r]yVqAsLbt%!T"m,2ݡRmaaa%φ"܈.iiu%I"_qjgWC52rrj~% }'`ȫ EaEaֱu۷mm,5/0WFZIDAT2KSɡ=uٷx}bvNnQa$IԍQ,կ"9f: }Q0Mj=GUJD}\TOue(,lmƪB+[pf]vg`"M^QUg,8.cᎇ!cF׌h8 v- ө(Jhh:(6-((HQ Vي仺 CC۲T8׎8VkDxR_xIDAT!CB7aZc,tL D0/Qrc5M`OE2/òlUodgg駁-d]srr&Lп;SſY%qk512EЬ 5!/jZE" 0@ֱ'Fw}cZ5OĸaVj4?S2O~С_|Xxq׮] ;;;))n F ,3ܹsЫW~8+++==E,[NHR/s߿|wJyIDATyVZ|U6c@|xvaƩ#!|&+7Oq')s3>T*ݻロF|9A?QlpذaCqqq||UuF|?xx˗'$$j M6mڴ;`V[jk׮>ObXżvǝJW#Z]iimF;,E&`PFK(]io[/L>֩S]v-"/IDAT׮];w'|B6v(رDd/߼y7nݺe˖駟Θ1㥗^*͛7?qqq۶m+**JJJWn۶m6m._SNMLLLomۮ^;IDAT:??_'jEϛ7fRRR/_4MϜ93::ѣ|Mrر-[ eyԩ!!!ҥKaa[oE5dȐΝ;ʪ1-˞+WqLch ѧ|wfK)bM&N3 %_t:hjfnAPe69 !@ŐRsm޼y\\ܦMN:… o&//^{̙3N|IDAT]vE{<իW8qSNy^^믿o7k֌dg6۵kw={l6ɹxb޽O:er!ϧ(N;vXk0@  B8:o޼mۆlڴeټ+W';;{(3['uԑ#G}ƏۨQ-[@AAAndYްaCjj?@޾}{e֭[wĉѣGM&S`0k׮]СC=֭[EOLIDATyݻwݻw IҨQ1ͭZڶmy~gVZ5lذիW77xc7n޽{w*`$bL,,SE/ t+U\ѣ0dȐ=zPj̙SN֭[?>cYVQJڻdtrխ[wƍtiV;wxTHDFK(h4% bY|dY8A.XW&Gi4a,;IDAT˅ &OLlԨիW@Hit$)ٰaCo4i2JjlȘAˑ->4n+?I(q,#E)lAɲ\+IR@4M\%KĠ/fIQd jvl6tT4MpGΝǏ?gΜiӦuЁdcR/N6($*{/Dɶ%( p8:t~z2_IDATRrM9hР'|2+++99955u޼yƍݷ #d)yg;鲬( 0.h|$$((K:wOtR|[%4nxٲefٳ>A /?x)y-2$IBuMѼ[SN5LNF'KUI4+Rhd3'LGt-drpe27e2"""Yfuh4!ȍ Sh4E:xIDATŋ<8''V) B PgxZ# uz GS rBkzM6=/صkW5 z4hl:ujRR[no$$$,Ydҥo$&&XdhlҤӧOӉ;vX||b7nܶmzꩧ O?y<DQl,vUܹwcW(**VXvZp8#((h֬Y֭#^]IDAT{.|h$Iׯy$''8l6ۗl9}#"y n?~ƍgիW7o"TZh;L<Ϟ=Yf4m2Nڭ[R_YU6hC~3_IgJݶ X$ {a(Ni9xر+ҺukpN>|8Fx+1bn V\\LFBx-Z?I-Z>h4pu>np|||bb# oп:ԬYs…dpG [pa-֭;bL(^Z=zW^`N799Y尰lHi:thHoq:yoţ_z IDAT<.(\!HDI ]-7WR=IՐ5tN5W-R=QR= gV!`6bԁNܿv;hqڏ FȇGDʩreggggeeRdrIDAT0FnݺAAAvsخe ƘVH=ZJڑܲ>22J Fb%֚Yk0WEW.իCUU*F;vĉزv}eKex P  Y7$]zbIFAvcƌ+o߾L,h"!!UP|\ْ$5nxew~4mE膓W:_| vuow N?u gIDATGEnF^+߿ܹ^8n82۬RuTGXk7rWᚎ%{ ^/q/@Ȳ,r~pyyrGQ(|>iZyx<:<(<EQ~NcYVE6GptNp8F#Ab8N"H ,wڵbŊO>$,,㸹sĵ_c#%K0pr_ξbi;ӇR r1!IDAT7\01Ɨ0W*>֮U㒧//^L%׭[u5kt(?KLok?׿E*yڵן?>))iΜ93fؼyF={68ѣG0`{ D4=~A5hРiӦ*GʶX,O4iRIãC&MjS8<"2װs:-T_H23r~glE[oUNelKIDATV3f\xqҤI/ɓ'۶mKJJtñts͘1<ς $Ix<sF{рw$I'N֭ƍmF3g>}:999|8̞=EÇꫯ^y/YܲeKBB'|hѢM.[,""|i:""$aIDAT 0`,lNIIrJ7sss{oIx_9fYoʣ:.^Y 4qA^9FC\v`IDATLBf`Mrwk3xpo‘MM.hsRtp(O>DKT$d[l;w./M6wݼyTeY^?yH)Tee3 EVVuMMM]~6c?]zIDAT?Xh4gkii1k)8Ecɫ F"/`,Dm,=6vSD1~ZtNfL&ehɉ>e|nۿNGGL:&IVU,+$%%^bHY@ucwhD=7[`̈́XE ƐBw޽{ܹ[ѣK.%O:`ni9 (LJ:IDATUUwt1- [0FѧwLϞX 9T*k'J6sL1>'Yf |>?yTIB}TAD? Z[ [-Y`V#WBوw^HUf=e0i)@ϳȻO9¸52yA$Hp7Jmȅy%+WtZhƀ#Fk: 偀`Ql=nz[1IDAT`,0$* s<C\ȅm)‘5⨑FG?p-[㸵kFb|M"/-l0gΜ'J***`̘1w`*$xRUQ[Ϝlخ;[,0`jo^sf^uƾ Niꫯ-VTTL>SJ<֭[[ZZHly^رR&斖l ~;fU/ȽIDATIB)PzK7!f:SAE!QXڛ_l9 ďI 3Klr^fcǎ?N7cy^/MBCC׬Y_&''m~wo fJi3|UkyC|Q;=f%CVKO7J"L&S*28IMQq,˪jF l0H[v]>gE[S0IDAT%PUjwݝ T66633?޼y30 o%fw li>q鯞WrUCڊ^taFc&+pJTwM<"g:s{֬YaӦMq܂ $$Dʛ .|W_b[4aaaZ6|#Mpq ~sL RRdFHI}JGF얳m%(Z1BB1Ek4v0DF'=#m[MUc={D2Ib>m$|^oEEEtt4EIDAT_Xf>g_zD ߌ7\<]}|#*0P! v M8E3qu`Fyl6={IjjjHr)z /悂j 2eŋgϞMxl6[hh(ɠyu:M1rp"`.4>CO[5qbҷPy~~![&$$`«W6mEQeee[AEIDAToy+ ô׭[Dzl0:N_DU~hѣN~~f$ `fӘao3-sc4MhY- "$FNW(쭨%Kttt\ryVkaa!)۷uu^{5bo{KΞ={Ŋ&L .---77{D_sx0RGR%vttTVVJ)?f6`jrMڶIDAT醅1 0Pn"0RaWlџ~DݯO-ӧOo„ %Kfs}}=)w}\Ֆ/!={={655ĉ#GŲe(//߰aCzzz\\\~~bv8˖-0a?~ܹ,Ç۷ԩSδiBBBjjjȉϟ?g---z~Ŋ⦦ꫤUV>|X^bETT}vP%IDATpݵDN8!?xϟOXr|߾}o&aaƏ|r*U*ŋCCC?"=v؟'i:77wś7o&~qƅ8Η^zIѤO:&##W̟?ʔ)g@3|>wCǧ??a$ !.ډZVөBPT\.h46(V˲,&5y;v}zDD7|> Vz+**>q\JJB`&;;[b?RtR1t({ʕ  6|G֭[l;yduu5 >ttt:uJŢޓCCCsUZRRT*H*8'B{{{RRҺuϟ(w'IDAT>%zY5Lv("MFQERXWWt:Bz^PBQj59wNg6u:hZVf3E+H H_ zRloo糳'MqeLNSPY,FCV)D`rJmWWrc@/ cv!24}{瓅R\l٘1cHZ3RO?Rӗ,Yb47mڔ@rr~i#Q 'IDAT$$f \p‚EM6bF;GV)**5kM{4M{ޞ={nݺuٲe7nx4ͪUHG 5#vn#v> #v:V F 0"5n5> 544 Fp$$If!vh5n5> 5#vn#v> #v:V F0"5n5> 544 F$$If!vh5n5> 5#vn#v> #v:V F0"5n5> 544 FDd b  c $A? ?3"`?2  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTU`cdefijklmnopqrstuvwxyz{|}~Root Entry Fӓob Data 2WordDocument ObjectPoolGoӓo_1329062387dO)GoGoOle CompObjObjInfo  !"#$%'()*+,-/ dO))Microsoft Office PowerPoint 97-2003-bildMSPresentationPowerPoint.Slide.89qnηGFmwr#IɂPNG  IHDR}gAMAPLTEU~ pHYs  ~IDATxAn08g1 [Vn%Ab4CK6uo@6i*_JddǟPictures Current UserJSummaryInformation( (PowerPoint Document( h bElO,+*qJ^KI%~xM P$p8Sk2 5^ ( )&02Q)Un fShJ=q%Q'ƚs`24)Q W>> 7 ãv=kO{u@V@ P3:~$8(88%\651 G c j"j X?ZAk@#28$CpjX-f'Utz@Е&Uv,0IKߡS$0d>a>\9ߜNd9cRN.!>Δ=>\ r<) K  ȅz)u[=*R(ͧ='̔+]Bl4)E'kUr[CO]9X[]kQOok*:^^MqygAiz%AɩIENDB`&_|karin grndahlkarin grndahlOh+'0 X`x  Geen diatitelSTANVBkarin grndahl3Microsoft PowerPoint@`GG@'B@ {D4՜.+,0    ~(/ 0DTimes New Roman̰6)0DArialNew Roman̰6)0 DArial Narrowan̰6)0"@0.  @n?" dd@  @@`` <8      ,b$ηGFmwr#Iɂc $0e0e     @  jJ 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||@8 >ʚ;ʚ;g4<d<d\E3A`2`20ppp@ )___PPT12 %0___PPT10 pp2___PPT9/ 0?  O  (PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!tableStyles.xml I0@Ὁwh}-CQ$ +w*!@he/?JXd45ݤ{c@qqi` yߥ?" dd@,?" ddu@ a" U J; n?" dd@   @@``@n?" dd@  @@``PR     ` p>   >    #PK!(b[Content_Types].xmln0 EAkP }l} m $_tI$svs^챐KkH$Q -G$oo1# ɩ5 J# \Qg0?0omRo?Y8 Jm i|TX+N3tr@9>?4 ΠMfrAsѺo_p?yjŝ & Xg3PK!*8 _rels/.rels 0DnzЃXmlo0of5OIw AN{cݠv=m 838yG 6U} ShLq`L)d=Ҍ\@.;3, ;$e͂): vq}j:zɥ'k茜(f,ƁXA6\m>PK!b&P#!drs/slideMasters/slideMaster1.xmln0'"N$֫jBk&8Ҳ`/؛Iv1QJs||?ܧԚ.E9EX6V,!1c1dqޗWrA}yXe9a6x%|;0vǶv|$,M N(0|1Krc-D}weHzD:[NS,9R%;7z1y Ța6޲Xʔ321WXZs ӉO?:&/02=BgÀF0Jԧ;"TQsC)/*;kP/w} =^7e:P-gr^ҤJ&\h_y𭰬oR/r]X຾tz*:`1u1`2#Æ{'i:[AڱH\J{nO:N{ K7SMk/TUYnO\g GvvnX>J~15,BVY*',&VVԾ&l@]C!@Q7PE{G{7a6%E*P^7Rr3]R@3Z3B Ѱe퐺A;+љ*%&CݠT寳fY\z+PK-!(b[Content_Types].xmlPK-!*8 *_rels/.relsPK-!b&P#!drs/slideMasters/slideMaster1.xmlPK l d  (    NIF?Rectangle 20P  0  HKF?Rectangle 3P  0:  HLF?Rectangle 4"d^PK!Zf[Content_Types].xmlMO &2WR=cJ`F0iK`#̼vLw 9uSq:w`G ^i ½KI)c/ $oVjTMRc|}042ҥCƔM̏P~*ka/8^DkHbL8e i"K\XN\6rco4y@_;oPK!1_a _rels/.relsj0 ѽqCNo^K [ILcX&m߾0XFo;>0xM e`|X}đ I`߽N4aG2$RKIZ)4(M9`ctB{m:f@`3n|O,ܗr޾jxR0T ,0@}WBLǬ5vPK!k50bdrs/shapexml.xmlUMS0wAk@hkYNȒGgrʡ!$kkzfSk+kr?8FRyΟO.9L f59_Ќz=/jipnkxP{gYvѫA~jL]j*KvgG)\K6.-1b;,/XJklػ!BBCUcmr> b0f#M` bCڣQX(o:ćHxJc)9 [9NȨrtL:ގ8MI)N16 q^U'z/&oQONe7߼)*no#Hc_^ kUI-,~x|0D R^MPK-!Zf[Content_Types].xmlPK-!1_a /_rels/.relsPK-!k50b*drs/shapexml.xmlPK-!WeNdrs/downrev.xmlPKS@ VC   <  c $ ? ̙33PK![Content_Types].xmlj0Eжr(΢Iw},-j4 wP-t#bΙ{UTU^hd}㨫)*1P' ^W0)T9<l#$yi};~@(Hu* Dנz/0ǰ $ X3aZ,D0j~3߶b~i>3\`?/[G\!-Rk.sԻ..a濭?PK!֧6 _rels/.relsj0 }Q%v/C/}(h"O = C?hv=Ʌ%[xp{۵_Pѣ<1H0ORBdJE4b$q_6LR7`0̞O,En7Lib/SeеPK!kytheme/theme/themeManager.xml M @}w7c(EbˮCAǠҟ7՛K Y, e.|,H,lxɴIsQ}#Ր ֵ+!,^$j=GW)E+& 8PK!< %2theme/theme/theme1.xmlZ[o~/pm|Op-q>D[v$9fHʢݳgc E73$8rd^i2r?\G&^jq3{w:E)_Di"G,ܟ> d,beEcϖi=I"L\'1z_Y. 0HRE˧_r&"_-&Q܉h|x"5AT6ftQ٤;kUcy9v5 FM]&ƿۘ%bDk[:fA?_v&ck>L δ3e LsHi˓4 ֯XI˥\"4n"g┏\ ;C9D48XuyVaqdްH!Yؖ2aH~,X"BNzq-+DeZ*aAO B^N&kI4(t]* Q[vņaaC랾lճjEkw,*aæh謴 8v{Jsw OD'gBC/Hl$+;O茧Skцbpg3{L0al1J~x"K&4 V/hr`fo94jkLC`+dyQNE(GFR@y?E f=ڦ˥ʺk=;uCi.e>{gkB?,ʑnKGvpց񉊉FQn Ɋ]զٞ; w( Wߙ(Od">YC :rӼ RD,YcAtt`syGWN"A.{fmKÈ=6"S^;P PnwD?^#h"7+TWa߮|!1ڲ+>nro]z)z p GZwfrbSbtVQ&?aE&Flu&$fpx;Ux8 UTDjuuKZ3Uʨ qM3;G**,,-]gU nC]KafD} ]|X#}PdcdW" .SrO#¿L|^;E.EXH ZLY0:":*&:: ؎HGX;Wp_0 JE_/^7i\?I$EhE+2iNJe/aBj’%mya#O|L.[n& Qzhc8[sWc<#E]!fN.([+ m2otT{ 55:t =f S|iZTAP:sȲG6ɻ/0:ȉi"Y-O%*+nWonᰢ)Co8ۉB٥Π.dHXO+kDx L-iD1݁V ~ēq~MUpS|jn7SY~_,)z 7jD7Jj7tY߃)j;pӛҥ.M~X~q1Y!RNvp7lӬPj6 eqC&`LZtFjT PK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 +_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!< %2theme/theme/theme1.xmlPK-! ѐ'A theme/theme/_rels/themeManager.xml.relsPK]< : PK!M[Content_Types].xml|N0 EHC-jaj; +,Kq:=ig ,?ϵYD&oDzCwO-gkcg$./XQ{jsԈHt䒦AFP0skfx(壓8?.C(ũ{R(Mb˳7{-IF#{_R'dK0FFjr'"&@_'PK!p8ܾ8 _rels/.rels 0Dnz x%ٶ6 (тqLݾQ(NAU ioo'tGHL m^W16 AJMȅ8a22~`Or[;,lij@搛}YMGBh ]pϔ{J Loc!"rPK!wf!drs/slideLayouts/slideLayout1.xmlUr0w=1&ȴiCӄ)w؃,i$!Ǻ,Rh1"vզdJq|Td_!F&8j|5yj$Ͳ[RAuB87F&QӜD I9|[Uje|ENWmbQH%ƃ(ʈu^Hd4}%T Ęya}˳#g* PX8)Vdj5HTB"̴͑+J>*9S睊BEf53 6ё2 dPdD`mD N$$Pӧ46oB`rHy"]ilyuwU@8tFB򦎦!=A0v|3ACJǯFo lTq Y{F062'JY;5Vj[/.'a*8;{Pi!fdĺ' <ʺfQ:![6E;lh圏ii~=jŌ(2no\\9?QrWJ5'*_+ z~UUb> [l!ASTS~:P ? !)>F&e儊ەGeBc!r3uC*{NJg}B(~7DR(mL5j'+#jk]ЍR*#&>HW i8':zg0x큞gɨ6 m~AWËJӯPueAJc"~F# ذ6Rxj7ΨM')8v,t<$#`pH]:Ȧku\E<]>Ʈ샄17b\#$hgH>`<Gkr63l^"3{#W^.hfӿ8ZI!Xvo)Tx5k|}3y~~_"鳔\&OBn>QJ״9?*Aa0 2Gy"1`5?% 022u^I/n2ɥ 5l)wc:l.ԪHhRhcq] O܇mB8[|uXM _brI$.oQ [n>N)(*(g(q ^ D7lI7$8iNs'L(pˮG9cCB-hrSn_xxb]ڻ#:vv,b/N}a~lsw;CuP:xg{3޷q`g{]P Q},cH.H/ OiS'NaE\PK-!M[Content_Types].xmlPK-!p8ܾ8 ._rels/.relsPK-!TɧU!drs/slideLayouts/slideLayout1.xmlPK8PK!M[Content_Types].xml|N0 EHC-jaj; +,Kq:=ig ,?ϵYD&oDzCwO-gkcg$./XQ{jsԈHt䒦AFP0skfx(壓8?.C(ũ{R(Mb˳7{-IF#{_R'dK0FFjr'"&@_'PK!p8ܾ8 _rels/.rels 0Dnz x%ٶ6 (тqLݾQ(NAU ioo'tGHL m^W16 AJMȅ8a22~`Or[;,lij@搛}YMGBh ]pϔ{J Loc!"rPK!X!drs/slideLayouts/slideLayout1.xmlWr6LA]0x;i,[`7쑅 }W b=,. &qqtom N&3;Ib=~#"lXm AAsej'2L(K" Y^ՎVIV>5I*x[.xzdߛdS"h_` `)Y

    "!&*qVT5`lZ:x$G<1i +.-IWFfYkIz R:jK@X68 lx `]:KXvr N/a؛KX 8''$`8ʋT/dIr#Z&N$gee3Ĕ:Anv=d=D^$AB'ߴɅ/49pbbevz cTd<\L&}ȼ, tkK/M?? "ߊNp2?u#wW*M[nqo4)=jtI3Sc!OZ*7{4NlnPJz4Nsm`޼Ѐt4'|&FSN#w|̲4ONȉu? ]<]te)b>V#$|{)&ߛ _[z TmPK-!M[Content_Types].xmlPK-!p8ܾ8 ._rels/.relsPK-!X!drs/slideLayouts/slideLayout1.xmlPKYpuPK!M[Content_Types].xml|N0 EHC-jaj; +,Kq:=ig ,?ϵYD&oDzCwO-gkcg$./XQ{jsԈHt䒦AFP0skfx(壓8?.C(ũ{R(Mb˳7{-IF#{_R'dK0FFjr'"&@_'PK!p8ܾ8 _rels/.rels 0Dnz x%ٶ6 (тqLݾQ(NAU ioo'tGHL m^W16 AJMȅ8a22~`Or[;,lij@搛}YMGBh ]pϔ{J Loc!"rPK!zxBn!drs/slideLayouts/slideLayout1.xmlRN0#-&=4~iٸ ^xǛ3 Cl9gJW6v=g!-A;rޫWgAлCdaC9cA@9,*"q/Jo6Zw@cK<eHaryTlHS,Ѱ%` J.d ;g}ALv)bltDB''Ⱥ Mu9=×D.2y WOgb&)C47AF[ i D<PK-!M[Content_Types].xmlPK-!p8ܾ8 ._rels/.relsPK-!zxBn!drs/slideLayouts/slideLayout1.xmlPK` PK!M[Content_Types].xml|N0 EHC-jaj; +,Kq:=ig ,?ϵYD&oDzCwO-gkcg$./XQ{jsԈHt䒦AFP0skfx(壓8?.C(ũ{R(Mb˳7{-IF#{_R'dK0FFjr'"&@_'PK!p8ܾ8 _rels/.rels 0Dnz x%ٶ6 (тqLݾQ(NAU ioo'tGHL m^W16 AJMȅ8a22~`Or[;,lij@搛}YMGBh ]pϔ{J Loc!"rPK!vإ!drs/slideLayouts/slideLayout1.xmlSKn0Y`9@R'P%"X3XI3|8qO"s-3!!Q"/IQZ [D 44{$)[ٟ߯#Zcי4ca^VcDS5߼h`/ 3DŽe*G Z=\GdPl'8ځhm7sSwBb*9 nY,e<_VM;y䊒g_A^F-X&| fGT)18rxPg`F=5JxQ(]+Vw t@ Ӑ[C`Vl;-ǐdZ5'Z Nae[06Zk'=9nwC`:*# Sgg洢!%$Bk6(70 w`;70l6@60<nm`݇ua'>>hMҁ1+0K+ qS<K"Q 6 J2ם\rSz/'-wy~9au O~gBhN݀`XA?xwpRis36 C}c0_T|2H33V5 PK-!M[Content_Types].xmlPK-!p8ܾ8 ._rels/.relsPK-!U2 !drs/slideLayouts/slideLayout1.xmlPK0PK!M[Content_Types].xml|N0 EHC-jaj; +,Kq:=ig ,?ϵYD&oDzCwO-gkcg$./XQ{jsԈHt䒦AFP0skfx(壓8?.C(ũ{R(Mb˳7{-IF#{_R'dK0FFjr'"&@_'PK!p8ܾ8 _rels/.rels 0Dnz x%ٶ6 (тqLݾQ(NAU ioo'tGHL m^W16 AJMȅ8a22~`Or[;,lij@搛}YMGBh ]pϔ{J Loc!"rPK!U-P+ !drs/slideLayouts/slideLayout1.xmln0O;XߑK *T[mҺLbHTDZl}/sKGZTLc/{Ls{?\ = )`coôw5yRƚtS 1{12ttd-JUP?ղ* ?4^藋Ee*0Y.uCmhR1 }HVG*&{2)1Z*O|T*9Se"yZj1S:ԗ *&4l؃mhֆ$2& $9!i ;Po"7 ,2yD(KA#_f䆳Z= iMj.QvGFDQ`n 5ҐCج?s:o(IVBԠ1ff6 | sġ h\cL͹|B!l >&Bi )p da9`L+G!gF!X+D:l 6䡉ߦkv@4Lau}*<1ؑ!F s2x0@MD%ͼwFaTȍ[Θ;(v,VArŞpp ׏@ т yy=oĴ yy=/FsM(Ra88"0gR`붯QH=irDJ ̢ B?" dd@,?" ddu@ a" U J; n?" dd@   @@``@n?" dd@  @@``PR     ` p>   >    #PK!(b[Content_Types].xmln0 EAkP }l} m $_tI$svs^챐KkH$Q -G$oo1# ɩ5 J# \Qg0?0omRo?Y8 Jm i|TX+N3tr@9>?4 ΠMfrAsѺo_p?yjŝ & Xg3PK!*8 _rels/.rels 0DnzЃXmlo0of5OIw AN{cݠv=m 838yG 6U} ShLq`L)d=Ҍ\@.;3, ;$e͂): vq}j:zɥ'k茜(f,ƁXA6\m>PK!b&P#!drs/slideMasters/slideMaster1.xmln0'"N$֫jBk&8Ҳ`/؛Iv1QJs||?ܧԚ.E9EX6V,!1c1dqޗWrA}yXe9a6x%|;0vǶv|$,M N(0|1Krc-D}weHzD:[NS,9R%;7z1y Ța6޲Xʔ321WXZs ӉO?:&/02=BgÀF0Jԧ;"TQsC)/*;kP/w} =^7e:P-gr^ҤJ&\h_y𭰬oR/r]X຾tz*:`1u1`2#Æ{'i:[AڱH\J{nO:N{ K7SMk/TUYnO\g GvvnX>J~15,BVY*',&VVԾ&l@]C!@Q7PE{G{7a6%E*P^7Rr3]R@3Z3B Ѱe퐺A;+љ*%&CݠT寳fY\z+PK-!(b[Content_Types].xmlPK-!*8 *_rels/.relsPK-!b&P#!drs/slideMasters/slideMaster1.xmlPK t.l. .(  _  ``s?Rectangle 5"ËPK!Zf[Content_Types].xmlMO &2WR=cJ`F0iK`#̼vLw 9uSq:w`G ^i ½KI)c/ $oVjTMRc|}042ҥCƔM̏P~*ka/8^DkHbL8e i"K\XN\6rco4y@_;oPK!1_a _rels/.relsj0 ѽqCNo^K [ILcX&m߾0XFo;>0xM e`|X}đ I`߽N4aG2$RKIZ)4(M9`ctB{m:f@`3n|O,ܗr޾jxR0T ,0@}WBLǬ5vPK!o#drs/shapexml.xmlUN1}ZA (X ()fč/+۹s!i2H!b"[uˀCd3U˙)GR`S-Y>- ;Y8{I]u/ZavuͩU8ٺ8MЗ^^^DukC.gOt'WR{uA9.EJVճt|Ԟ-AcuOrj{j2*E:;M,ENhe[\3L$VV4Jg'-MR,#3UܢpV̜/>q7HH;MtH~@AcD^EL LST=Y% 7܄-a`kg=}RB@(4='Ae.y=ǍHFhPļ͝&<dw8/~r;Yb7+ue&5Q:2| 2slwAi]6'D(֍l.}u2@;bE_th&_1n;WL|0THe]ČݎqQ;FH6F 22Wb#gr֨(f`F*f%}3 ["|8a>P PK!Ydrs/downrev.xmlDMK1E!0w60BG>wr:>]+O\:>?P]m >/j{_]*u|/@0?YL_R+< _5& el rPK-!Zf[Content_Types].xmlPK-!1_a /_rels/.relsPK-!o#*drs/shapexml.xmlPK-!Y{drs/downrev.xmlPKP 6   zA??cbg_logoPicture 6cbg_logo@  H@s?Rectangle 7"|PK!Zf[Content_Types].xmlMO &2WR=cJ`F0iK`#̼vLw 9uSq:w`G ^i ½KI)c/ $oVjTMRc|}042ҥCƔM̏P~*ka/8^DkHbL8e i"K\XN\6rco4y@_;oPK!1_a _rels/.relsj0 ѽqCNo^K [ILcX&m߾0XFo;>0xM e`|X}đ I`߽N4aG2$RKIZ)4(M9`ctB{m:f@`3n|O,ܗr޾jxR0T ,0@}WBLǬ5vPK!^drs/shapexml.xmlUMo0 t8EtA"-AZ-dHW(IbE>>WZt^Y3i-sə`JȜףo^6~|B3vXgHgu5|un㤗&@DeEeCh1U|S>HZ>Ċo)l00coC#1[ yD9+6?lXa,VmSQ8zY?r~ 2 609_DMړQ(BzC$"3Ni}*T6a9?;' EUiU)ݓ)%!Ϋ ǪOY{F?lol šJN0 ;ܝ_7C9jp8@^kUD %IsV3ק!w!yK$ʚ0+xəF1޸ӕ>BfֈhFLE`k PÏ7z1<W/~iqK=*Vye^Qs),ҖxH* '遼.WO(Ŋsnt~("Lc(N-QRA+P[FM]g^#Zf0vꬭu0TF˗6谂V2*Q?# J $ا^rjbZV1Lkkdэ(%]Sm: @VV]>/J i)8f/tfm_z$v PK!Xdrs/downrev.xmlDN0DHH\*CB݊9 A~&&Qudiگь-ף@η̦ kadeRp!Smϼ!)*hBS)}ՐA?=q 1Zj7|L4r|hmC1?W6.k} Eh rPK-!Zf[Content_Types].xmlPK-!1_a /_rels/.relsPK-!^*drs/shapexml.xmlPK-!Xmdrs/downrev.xmlPKq@`  CBG-MEB& C C      N`s?Rectangle 20P  0  Hs?Rectangle 3P  09   Hs?Rectangle 4"93PK!Zf[Content_Types].xmlMO &2WR=cJ`F0iK`#̼vLw 9uSq:w`G ^i ½KI)c/ $oVjTMRc|}042ҥCƔM̏P~*ka/8^DkHbL8e i"K\XN\6rco4y@_;oPK!1_a _rels/.relsj0 ѽqCNo^K [ILcX&m߾0XFo;>0xM e`|X}đ I`߽N4aG2$RKIZ)4(M9`ctB{m:f@`3n|O,ܗr޾jxR0T ,0@}WBLǬ5vPK!I &o drs/shapexml.xmlVQo6~@upm'NU m^`LKT"5r ('YPlCǾGtww~~W>Tfrf +*{_{c)BTPYɽ?k&؆IuͤZ*q+UQE8Md08תv,;ഀIX()nzQ{8vd:}J@b+`A!j+}}lDdǕ`0 P}&G$#5ѻ(r(>xRl|; C(().ȝuו1fC4X3PMa?bG[*dc,ӅK+W xjg+i\;(ŃW n i)g FgWT fƶ&9f2JYĉFŹ]69)HqM+knr&].vJ1!.}dJ (-^QS׬dkK~mĎFi$w89o9nYKlY!dwjD$\^Ǥ^ )'`}цhm9TUB/(?BJu?N/zZ'a<ny&[&NxKLMJSda;7:?9퍇WXeogxz6v\cr lںU*Ikz74ڙEbHkWɺ%KRlJ9iHMW֣|,-s%ˡ3Lux9Lɔ83UA5қwiea|Hj;][2L/ VzuU-yxuÐc( ߴ⥠v@n   6Nl^_ET˿PK!|drs/downrev.xmlDAK1!**kDAJ*x7dIbw^֗D1?!ghM1QАݲiPK-!Zf[Content_Types].xmlPK-!1_a /_rels/.relsPK-!I &o *drs/shapexml.xmlPK-!|%drs/downrev.xmlPK(  h*(C C  Hs?Rectangle 8"PK!Zf[Content_Types].xmlMO &2WR=cJ`F0iK`#̼vLw 9uSq:w`G ^i ½KI)c/ $oVjTMRc|}042ҥCƔM̏P~*ka/8^DkHbL8e i"K\XN\6rco4y@_;oPK!1_a _rels/.relsj0 ѽqCNo^K [ILcX&m߾0XFo;>0xM e`|X}đ I`߽N4aG2$RKIZ)4(M9`ctB{m:f@`3n|O,ܗr޾jxR0T ,0@}WBLǬ5vPK!OgKdrs/shapexml.xmlUo0~GF1RbTj8kc|g+L!K{Νwߝ߾4Z5JLaeX ȔQ*/ߝ?V6`jȿ2U5ptw)L@j#ʬܱT\Ne&HaAU ;XzdNafItt~Abԅs~q1]ir.Rm,JM&kez+϶U 4T9cJ h|<m&OOΆQM& ^N٠34%2aAك(zጽ>X6ᄚ:('tdH>ȼxo(PbD2;Җ[v-O<ŤƥuR;eB2` !vT &Ycfju=^3 'qpbjئ03`)n7_ɵ}[umKjﺛlc D[ D_k=ӤT pI1K1h̑=Ӆ޹FzG< YM2צr";lb-2|JbW th^Y.╜<ݫya;SDn& -Ekb<;xoq-{E`kn&N-+xSVĮ+ k̔sr^uMou5gR/#D]& 8a"JR㗐# ސO4]?Ƞ_ƨ;k(&L"IͰ[p u[/T($lJUnfz:vˑNksĵp[mF׉zp=W +oZ5=]-AĄlL&Y0~NT X&2V 9s0ji:PV:l9?4Ӯ4ff1Sr;yŸ}hLAw_z1A3Ę(hn4[\PK-!Zf[Content_Types].xmlPK-!1_a /_rels/.relsPK-!OgK*drs/shapexml.xmlPK-!drs/downrev.xmlPK  BC     Hs?Rectangle 9"PK!Zf[Content_Types].xmlMO &2WR=cJ`F0iK`#̼vLw 9uSq:w`G ^i ½KI)c/ $oVjTMRc|}042ҥCƔM̏P~*ka/8^DkHbL8e i"K\XN\6rco4y@_;oPK!1_a _rels/.relsj0 ѽqCNo^K [ILcX&m߾0XFo;>0xM e`|X}đ I`߽N4aG2$RKIZ)4(M9`ctB{m:f@`3n|O,ܗr޾jxR0T ,0@}WBLǬ5vPK!#fhPdrs/shapexml.xmlUo0~GF[(lV1@*S$vv=ߝuL!K{Νwߝ߽4FJmfщ!*[*Vw$m\NP,uKj ]|"vz*"Pc÷FV]/ڹ'ZϽKTjZhq*QWHbU3QI% aG:FKD޻Veψ;vZIK-T)5uj}5+q]u 5T9JPXn3v||L2Q 7'19Fg8 Y>ď Gh'Wֳ } gem̡pjjS H`KUmbeP{!qs-9񏖧wb\{)mqNKa>[t4Q)cMXcf S_^3H4DpM.ڂ w|SA+XVɖ` '&Eb}͈WRWqDtf56QTy{#{ ٹFq#GF ږؐ,*sul@f7*_*zcjf/+g9_U P{53lyg vxP3Im1/X+{ ]=m kϫ^wSo6<8y/Q M?[y+ .1[ΕWUԍ^'PQs&=Hk 4vBWu XiO!G4a!,=lןHGͽsˡS\$f-T zD5 J=8 <|⃻[Nj}}5nA$xPrT&2}֔ yS3PK-!Zf[Content_Types].xmlPK-!1_a /_rels/.relsPK-!#fhP*drs/shapexml.xmlPK-!zdrs/downrev.xmlPKp@   BC  <  c $ ? ̙33PK![Content_Types].xmlj0Eжr(΢Iw},-j4 wP-t#bΙ{UTU^hd}㨫)*1P' ^W0)T9<l#$yi};~@(Hu* Dנz/0ǰ $ X3aZ,D0j~3߶b~i>3\`?/[G\!-Rk.sԻ..a濭?PK!֧6 _rels/.relsj0 }Q%v/C/}(h"O = C?hv=Ʌ%[xp{۵_Pѣ<1H0ORBdJE4b$q_6LR7`0̞O,En7Lib/SeеPK!kytheme/theme/themeManager.xml M @}w7c(EbˮCAǠҟ7՛K Y, e.|,H,lxɴIsQ}#Ր ֵ+!,^$j=GW)E+& 8PK!z@ '2theme/theme/theme1.xmlZ[o~/pm|Op|i lA-і6Pt̐E+&= H(j4\!?msYY:?|Azq;w{biD =TO%RY@7+~r³U&VBo":,aq{)Km`+b*;L0*#rym%Mwm$.z9һgb}x. Pu9 !:Pu^%?"`An&Vtλ ġȦnj*Dٯяdzḋ4FߙvWD8QO7%*grx#=SO=|pݱ>1)]rVyb pMޱvBȉ+Uhb!QZd"Љy<ѯCdUX'U z]xyV0I8(Zi ~BݭdC0_S̰uu_6X[Yij;h`úhYj 1 VWL5 mۯb"b!76B6jPyF4FUF"vZ%V)ZGV)Ra,+MLrz}5$@ILYsh ݲ58BMYiנGD#w@{?E蚖VQ1hL3!jU9]ez ۓs'N JT; Oy7D PK!^G~&UAʣ8Ky(vx]0]{9xx$0kܥYZFQsq1p"pu&& ݾA59U91̽v Bq r-6V2gQURNT#VMNNX:˂(g*XbWf7[=X"3pw0@%NS;Ҫ5-j&W)v&(S6{8ss6vtU5Xvе 2 mGT7 g0i ۨv%|VޖBܣ pö Eڢھl 3uvQ|wl+ئ)j GVftfh ]EP~Q[+إ6iHӈ8 giHܑ^9!$  [DX,uX:t`;2 w27L֗v ^z>YVdAh34ls},|Ly8TO&sE˧l+_">ђ8Z d" ]a;k.a#4n!QSWR+_ݲT[ycz%嗀cZ,Y}9wIbO3BQ5LI3E֒bkG[F<=Bg<]n`x%Yn_&nÔ7όS--@7M'd6黟`a @N4H4zmd|a!2. 4  EM[#=[BgZe`}U@ /O{yhΒX` bdWm7$r@jy l *R@EM[F=c-jE(j` ^~BM WN ,!T1o\x~C.X-gP oP;>hQ'|VFa{)ikizg{I A| {FdTGIn:T[Q9=~pd!0:@`C؃1[-wHۣo<rvFp[ܡo8F=9|8<e[Wt"BD!nA*ֻq Iq}ܔ*4|TJVl~ݮ1taIk,S3|sqֈD~gPn$觥"ݬf<L4΃D3mMU0nēi~MUpS8>ՀJ,͔~KڥMC n ⦔B/ /gps=1EO7)^axnN ڏq|GX9.ݬfW_M&Ѹz 7ը9xf_`M1Q pUq3u nqsժ,MG4np}|e8봋O7W}4^`n4WPK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 +_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!z@ '2theme/theme/theme1.xmlPK-! ѐ'E theme/theme/_rels/themeManager.xml.relsPK]@ : PK!M[Content_Types].xml|N0 EHC-jaj; +,Kq:=ig ,?ϵYD&oDzCwO-gkcg$./XQ{jsԈHt䒦AFP0skfx(壓8?.C(ũ{R(Mb˳7{-IF#{_R'dK0FFjr'"&@_'PK!p8ܾ8 _rels/.rels 0Dnz x%ٶ6 (тqLݾQ(NAU ioo'tGHL m^W16 AJMȅ8a22~`Or[;,lij@搛}YMGBh ]pϔ{J Loc!"rPK!؁ j!drs/slideLayouts/slideLayout1.xmlT]o0}`W4[B)cHTǶl'$~vBiWMHS_s}qjҥ D9yj m01΂~Tf ܉ :ó0FfaIA+BU:GXD8pɃ^]R/Ɠ(ʰ뢔z`IE5иG҅8>amb: 0 WH #+H*_v%݊[E旒R`٬*sKa'vg jI;" 5K:66vhbRP7(JN A^4*RXPk͓e3leˢu :u'PC''Q2 M6~#(Mo" %It7sQ0xM e`|X}đ I`߽N4aG2$RKIZ)4(M9`ctB{m:f@`3n|O,ܗr޾jxR0T ,0@}WBLǬ5vPK!jHdrs/shapexml.xmlUn6}/ ZdmI1VY$F-FE)USJRP] \Μq>frn,+k/QRgu&:ȏw?V 6hnTxZmqV9ߨW:jF1Qj+`n“T=^m}dn7}ۮ*}7j)ҮDܷrUz;,/W j|sndUeEQGήoP3y'ևI#d(f"xtA{97ms͈m&o/9[njS$/JݖUme̫ #s"Ԩ{rDJ]GP+ߤz&`-ӂ+0& sF zخ9ÍlR$qFsM.ۂڽVA'\V?I` #&ecL ژ #N#x}(($94Q3jBc`BŦ0,J{_+V Lw9'3x'6Yapls- <_Ee^*"{QI1PBVs׬^9Jч>P]t` qSd'9*};<wp-#R9׀(1>DN0nn{:2Lk@Nt~iVi᫃"{zt<6PK![3Ydrs/downrev.xmlDJ1EZMKUD:Up N^$3op˽Y׉zp9U +oZ5>^܀ `4a:=YbaK:S-2cBX50N}O;Ôc xpəRa>N-w[5wsdfVas "ѐ%_z6b>5%DAC˲YPK-!Zf[Content_Types].xmlPK-!1_a /_rels/.relsPK-!jH*drs/shapexml.xmlPK-![3Ydrs/downrev.xmlPKP    X C    H`s?Rectangle 3"PK!Zf[Content_Types].xmlMO &2WR=cJ`F0iK`#̼vLw 9uSq:w`G ^i ½KI)c/ $oVjTMRc|}042ҥCƔM̏P~*ka/8^DkHbL8e i"K\XN\6rco4y@_;oPK!1_a _rels/.relsj0 ѽqCNo^K [ILcX&m߾0XFo;>0xM e`|X}đ I`߽N4aG2$RKIZ)4(M9`ctB{m:f@`3n|O,ܗr޾jxR0T ,0@}WBLǬ5vPK!*$drs/shapexml.xmlUn7}/ Z8|m!ⴀb>S\k#.%sf+)Af83g>nk#ڇL 6wEe_3ٍ!*[(N>4\adrc3 BԵ \-t8Au6@+73ORyQ^_IaU:GF 9 4._.3^mPwi>{T2BL7Y"mZFקj),E5Ȳo)/Fx[ȏ+K77L)q5(roG7ʡ&3,@v'#Q&=Z54A{9xS݈M&oί8{0UIOlUe ,eţS"h; /蔦יGοI CmR,;c"3RcXcz 9fsIĉFũ79{|'OnT/$[fnq5q"$kmF4ʼb3z!4.I iGV3Eg\o}bYʱ} X*4zbřFU| O)Y@Hlb@f/j1GQ d>{m>ibZ{@1#BYt?]vb˖Gy#JvӾHLShDP,[[̔WU[WZ%`Qw&9{U! mnGzt}E$J{zy4!`5՛f;W81ZUIUe^îQb|ܦ:cکkM'3o:gZyny PK!pdrs/downrev.xmlDMK1E!ga 3Ę(hzY6\PK-!Zf[Content_Types].xmlPK-!1_a /_rels/.relsPK-!*$*drs/shapexml.xmlPK-!pdrs/downrev.xmlPK    Z(C    H ?Rectangle 4     Hs?Rectangle 5"xrPK!Zf[Content_Types].xmlMO &2WR=cJ`F0iK`#̼vLw 9uSq:w`G ^i ½KI)c/ $oVjTMRc|}042ҥCƔM̏P~*ka/8^DkHbL8e i"K\XN\6rco4y@_;oPK!1_a _rels/.relsj0 ѽqCNo^K [ILcX&m߾0XFo;>0xM e`|X}đ I`߽N4aG2$RKIZ)4(M9`ctB{m:f@`3n|O,ܗr޾jxR0T ,0@}WBLǬ5vPK! -drs/shapexml.xmlXn#7 }/Zd};Y$A-FbyFOƗ|}qnb]!8EQ!/ڈr6})]QٻLysyp"E83A~984m7\،{/thZE,]:hUE ZUV”]Κ')ZNLƭ:wF# 7&./{|)Z!nzD2bnЪ1[W-<%_^]ZU>j/tgy 7 l1_ WmtCץw츲`4#L^Gc?|H`0:I 6>į C'G ٧+:.+cv4vW3bGp-R,LUgPUee#]"ԈGP5 H)V^ZKa~ !?ߙ?߱m} KV3HEĊՍ;krRܖMW85{f ` #&Yܠw gt~X pY0K*[Q博Zd1ik5Kg@BOSPc r=D7`{U:\MRsp'>I{tbf,Iq="(rei™AKT4'yo+Yu0ZT6f03ZT>^4(e%ϵ0BvdxJ*w7U+qjeh/.U]f~P>h.ճ@j#|J<`}=>xE6PBd)e0Ǎ zIB|ؓpk/u֞ZNhϭ=gӥS%~tPK!}drs/downrev.xmlDMK1E!0xM e`|X}đ I`߽N4aG2$RKIZ)4(M9`ctB{m:f@`3n|O,ܗr޾jxR0T ,0@}WBLǬ5vPK!qYHdrs/shapexml.xmlUn6}/ ZdmlUl 3%QjTIʗ|} %]bmP̙ϻƈv6c)-\Y۷LtQ-qVgr|ih0m3FXF{XQu6G]7FVÔ,ۅ'x,L7,B//]'9ޠS j[0Yt `HOw53g-`5IE|iUe[@ݟʷ=q"(+Oe:%Ȉ qgB¶6fˆ)uE!-(6 us(uPPs)@#RAY މM}Vdj]m6\ /,%k[bl^UDRLǤ>5W>@4b1-0xM e`|X}đ I`߽N4aG2$RKIZ)4(M9`ctB{m:f@`3n|O,ܗr޾jxR0T ,0@}WBLǬ5vPK!Bp* drs/shapexml.xmlVo"7~k D \+T}6ްkom/T{7pJ=U.`7R0:w=ΤNMV4pЙPF˄H?j*ڍoݮK7Ynl)<sI텇Ru/zn) oaJVҒ>얖Y/{gZ(S$no05%b? i">|ZH9~!6TH)jK(x&ZX/-G*_59&8[5,"ƇܖfDvL3✽$˃g).F>Rh L HHJEECbp>j];mRBrT\3lU8F,JTQEPeuT(T@C@)}BEh|u`m/&z!Py]^9Ry{xjlؾLc( 1Ts~؛ z\/;7}b6 &d> f5[+d¢2ۺ,JGUaOh* 5 q[l^ڬVZa5Fjߪx?G**- -1y]J j9̹A6QEFs=O FC\le^4rhv8)NkP@H| RgKa}<>?>qB1n?PK!mdrs/downrev.xmlDN0DHuQ;A*%ԭ5 *džM|Xvd4{,r=vVB6NiJ8BDw$\(zu}Bx-K 8#ak7S-W nz 1MQu6y7>5϶$,bS/T#f{V{ d(PK-!Zf[Content_Types].xmlPK-!1_a /_rels/.relsPK-!Bp* *drs/shapexml.xmlPK-!mUdrs/downrev.xmlPK\`   p*(C  <  c $ ? ̙3380___PPT10.CQ? PK![Content_Types].xmlj0Eжr(΢Iw},-j4 wP-t#bΙ{UTU^hd}㨫)*1P' ^W0)T9<l#$yi};~@(Hu* Dנz/0ǰ $ X3aZ,D0j~3߶b~i>3\`?/[G\!-Rk.sԻ..a濭?PK!֧6 _rels/.relsj0 }Q%v/C/}(h"O = C?hv=Ʌ%[xp{۵_Pѣ<1H0ORBdJE4b$q_6LR7`0̞O,En7Lib/SeеPK!kytheme/theme/themeManager.xml M @}w7c(EbˮCAǠҟ7՛K Y, e.|,H,lxɴIsQ}#Ր ֵ+!,^$j=GW)E+& 8PK!@^1theme/theme/theme1.xmlYOo5# IMfhFmQY&jHH q Jĥ|@_g{f̒A7Rvޫ$ !)OAr=@$ Q;3]Z T8aSfD6}*P1I V*ۨdX^IanE6&֬Wk iR1 %K͂z d)|A& ='E401ku jWkx#0U'Ѥy=`[9=ayzu@LN;[%=,QWJxf>[[;Ζ'Yj 6۾3NJ|z2l9|cFTydC.s EaESfB  ;Ґd(h0_{WϟWϟ?|vG`iy wq _~_}~ǟW㥋jr/x'/oWMD: f KN|+148ŚK{[3pn+( }O~,*wٍ8{m.*pCr?Q5s1uqV4HHvb≹ppDRB*pRϮ{4\B(ƴ$:ih&Yo6{w6gUZwɡBaINkXUBg"tq;R#8)P=ݾfNhĜ.tbdU>Mc@bU|8]x>ܡ'"@Th_BpBӷyKʔ=QNV#/] 'hPK!(b[Content_Types].xmln0 EAkP }l} m $_tI$svs^챐KkH$Q -G$oo1# ɩ5 J# \Qg0?0omRo?Y8 Jm i|TX+N3tr@9>?4 ΠMfrAsѺo_p?yjŝ & Xg3PK!*8 _rels/.rels 0DnzЃXmlo0of5OIw AN{cݠv=m 838yG 6U} ShLq`L)d=Ҍ\@.;3, ;$e͂): vq}j:zɥ'k茜(f,ƁXA6\m>PK!' =9 !drs/slideMasters/slideMaster1.xmln0+;XjwũZU-㐨.} Fzd~S+UFg9xYk{C?6Bg0[rKwn6JTId88ыDT"*]x49DTФƗ8=PK-!(b[Content_Types].xmlPK-!*8 *_rels/.relsPK-!' =9 !drs/slideMasters/slideMaster1.xmlPK tl T(     `sjJ?Rectangle 3@ 6   `sjJ?Rectangle 4@  6   ``BjJ?Rectangle 5 @ 6   F AF?Text Box 6p  nModule n TOC.pdf 2C    FBF?Text Box 7 p  j Document.pdf 2 C    Fs?Text Box 8@ i CTD TOC.pdf 2 C  v    C (Group 9" B   XjJ?Line 10 B   ^jJ?Line 11  x    C *Group 12" B   XjJ?Line 13 B   ^jJ?Line 14  x    C *Group 15"@ B   XjJ?Line 16 B   ^jJ?Line 17  B  ^jJ?Line 18PB  XjJ?Line 19/`/B  XjJ?Line 200 ``0B  @ ^jJ?Line 210 @`0   N jJ?Text Box 22pP g h (bookmark) 2 C    N jJ?Text Box 23 h (bookmark) 2 C    N@ jJ?Text Box 24  g bookmarks 2 C    N` jJ?Text Box 25P`7 {hypertext links* 2CC    N@^jJ?Text Box 26 `  {hypertext links* 2CC   ̙33"rPnuhDocumentSummaryInformation81TableBSummaryInformation(&DocumentSummaryInformation8 X!Bildspel p skrmen (4:3)VWS# Times New RomanArial Arial Narrowcbg_presentatie1_cbg_presentatieBild 2 Anvnt teckensnittTema BildrubrikerOh+'0  4    < !"#$%&'()*+,-./0123456789:;=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}]߿p|z `!]߿p|֢r1`ER4x] pTu>ow%8dI "CГwYc@#jŸ Xf"eZ'qRJgJkgi܌]ĆNm&f&!!a 1]],Zv5+=w9スo$WZl) ?+4XbXR ea3!lsȉ "8e19-8ɯ3rX"^Bp{_.  i@@qwX%_=Ysvy'Y2:m?W>utԕ9cv OEpx|JuJ06wO2n#6IA)焎 nG}/mN0T12lϹÔCnsG8s詃22Qʄe/GAoҫA,]ƿ˫'ZGVm6r42G&3^H7hm@qZ+sAs5?'D4~ dDwg'?<{~hǣqu\Ŷ6@'2$P(s,9O`$Y̛ Iq/eW6th\7H(s)5wXu" h X_6⮦uĥOrEg/W<lz2@d@Iu"d߬~.z6J\6Q)f M| <-'O },%>b-ԞSV.=5/puʥE5?-MUu|pu|#!n"Nk(20mq2|}Ut틚mnySOgcPXJ!'Ő6P H/ B^wv$UbsTcDZ :Dߏx+6kRdH^zY;|@Z@_=5~nJ`·!WD?7̻ybu>A*|/5ͨ/yFR Mߞc \|\擧TwϷǯG,=~]^]=vֲ qbG_-q3/s.?šVc>ֶ)įc9g<0ՙ8|K 5}'N3,B$41l*l~lE²X*ID넆@tƧwݸ?rƵSG?Άz "?9F1탩dJg/nL7u}Y{]owecuXS\ %@Аݸw2C$+LjcY/<Ձ\_&E}x~' 0 Pw?++t`g߰y:e·#z*7MkEz|po_,'}h|>y_d|?y+j`܏Ecd׮/{l|f|}}e'@Km1퀩&xQS72Mkae^A}VcƬԽ7hglhVD_TВS|% 0=o;ߕB9ʶlk2wLP3%td=lJE#g)S8<iY >gzi /2vw<{<5Ǵ$'W0߄Sy}6T#HPD|\L܇"T?.$=7!s~82hCF,? qDeG mb AaeȮԽELoG(3|6}|~DG^ʳot}uL mﷁO;_9qYl:|ŦwF=5@$69Lۼ.4os}>~yŦ[ٴc9Q)uV@7Sik=Lkdя~D=j/%>?&p_5}.9,`i5WF5[MTFȶfcr`ۏa8CÀ7g|p do{9qt3w=wvFOW =vs_ z ׮Ĺ?3?9 ~Kܼ"3w46-i~IT N`q; uBqh{;{̢ྗqXL-s9Ws%ɾQs8,Os87y;xdcF7Mu:}ۡ˃b7ߐP&x.hlй7_sKV:;^1.8W˽߯M qod_eyv MN ۼޝam}Um_AϳG7#D(wb(r^Rb7ߝpJԽ nzwb9OR{^vs,M}!Y yg:Lޛq}>1q&M]{c8m؟w5{w .V:ޝk8f߅= 4Rvs+޳8=ٵ4Σ.9VE4G,v|lc!¹m4o +a 6`wj7AW ~Ε̣o*'9?:L=Cs'T{k<ɔ3}1u_f{[̺LzQbᄒOps|LݜGzZe(=S'St9S{cH;8~qyH~T:ޡ؍q( 0瓐7=1׾xQS72Mkae^Ǟw_ps|LݜGQ?0g鹟]T.%Ouo`/>gU )OچK{!sݛz:mu}1u.3Խf]u}|T/Qcu2"#->Q]F癏zFQ1ç901lD(~EOs>x7}hU|[M|7^ M)r;^#HjODlgUs]H!PZ[AfͰޢ rL]sbx'W ϞnC 爓nN$T6GsO~Y?9┅2E4s|[.](O+C'x;&Vh\܃49etZ4 ز[ĉW[B'嘂:t)')~-Wb!ޑJ-Vڌ;s4.<͟nNMlr% eF{[ׯ(uSARXTgUa>RLe)Q={}dcKxsx}ֵhG6ϕA\d.|/=m{& 8ʊ3DXjD8*ɏ&w4薇Բy3lgL(7_z5%S,]tf23H/UCnpҖۺpV~y^Юjn1;zPAyBAsPVUxJg}W맰8?߹H1/+|zPSݯ'[ȧdX~EȟûPUzeg uUKPϵf*}U I=Uj̰Z PgA߅2wYA7ma0!(}q{b&o<^5[lشz)˅ fO9ZCo|.KtlZr6OՋYo=hk-;7߼a:>G OY?xx0kr??gWOX_eϫceݶW,C3y@ ` l x Nees eGuidance Document David Wheeler for Topic GroupNormalkarin grndahl2Microsoft Office Word@F#@&@o@o!k  F'Microsoft Office Word 97-2003-dokument MSWordDocWord.Document.89qvz _Toc255322973<z _Toc255322972<z _Toc255322971<z _Toc255322970<z _Toc255322969<z _Toc255322968<z _Toc255322967<z _Toc255322966<z _Toc255322965<zz _Toc255322964<tz _Toc255322963<nz _Toc255322962<hz _Toc255322961<bz _Toc255322960<\z _Toc255322959<Vz _Toc255322958<Pz _Toc255322957<Jz _Toc255322956<Dz _Toc255322955<>z _Toc255322954<8z _Toc255322953<2z _Toc255322952<,z _Toc255322951<&z _Toc255322950< z _Toc255322949<z _Toc255322948<z _Toc255322947<z _Toc255322946<z _Toc255322945<z _Toc2553229448http://estri.ich.org/eCTD/eCTD_Specification_v3_2_2.pdfz  P1935 _Hlt251138987 _Hlt181592229 _Hlt181592230 _Hlt181431301 _Hlt181431302 _Hlt251139024 _Toc251147883 _Toc255322953 _Hlt253985979 _Hlt256453848 _Hlt256453849 _Toc255322954 _Toc224630252 _Toc226191642 _Toc226191755 _Toc226192015 _Toc226193130 _Toc255322955 _Toc224630253 _Toc226191643 _Toc226191756 _Toc226192016 _Toc226193131 _Toc255322956 _Toc224630254 _Toc226191757 _Toc224630257 _Toc226191644 _Toc226191760 _Toc226192017 _Toc226193132 _Toc255322957 _Hlt217708386 _Toc224630255 _Toc226191758 _Toc255322958 _Toc224630256 _Toc226191759 _Toc255322959 _Hlt252684552 _Hlt252684553 _Hlt217708675 _Hlt217708676 _Hlt251140417 _Toc255322960 _Toc255322961 _Toc452788152 _Toc255322962 _Toc224630260 _Toc226191647 _Toc226191763 _Toc226192020 _Toc226193135 _Toc255322963 _Toc255՜.+,D՜.+,| hp  0Dell Computer Corporation|l Nees eGuidance DocumentNees eGuidance DocumentNees eGuidance Document RubrikTitelTitle 8@ _PID_HLINKSAPfi}http://www.hma.eu/277.htmlz  zJhttp://esubmission.ema.europa.eu/doc/EU NeeS validation Criteria v1.0.pdfz fiwhttp://www.hma.eu/277.htmlz /t&http://en.wikipedia.org/wiki/ISO_9660z Gq3http://en.wikipedia.org/wiki/Universal_Disk_Formatz finhttp://www.hma.eu/277.htmlz \khttp://www.hma.eu/91.htmlz H4h]http://ec.europa.eu/enterprise/sectors/pharmaceuticals/documents/eudralex/vol-2/index_en.htmz fiehttp://www.hma.eu/277.htmlz fibhttp://www.hma.eu/277.htmlz  _Jhttp://esubmission.ema.europa.eu/doc/EU NeeS validation Criteria v1.0.pdfz  \Jhttp://esubmission.ema.europa.eu/doc/EU NeeS validation Criteria v1.0.pdfz ZYhttp://estri.ich.org/z fiVhttp://www.hma.eu/277.htmlz n/S8http://estri.ich.org/eCTD/eCTD_Specification_v3_2_2.pdfz  Pz  _1._General>Mnhttp://ec.europa.eu/enterprise/sectors/pharmaceuticals/files/eudralex/vol-2/b/ectd_01-20006/ectdpaperv1.0.pdfz fiJhttp://www.hma.eu/277.htmlz H4G]http://ec.europa.eu/enterprise/sectors/pharmaceuticals/documents/eudralex/vol-2/index_en.htmz H4D]http://ec.europa.eu/enterprise/sectors/pharmaceuticals/documents/eudralex/vol-2/index_en.htmz 29A8http://www.ich.org/MediaServer.jser?@_ID=554&@_MODE=GLBz -T>z _Annex_2_Example m;0http://esubmission.ema.europa.eu/doc/index.htmlz `Y8Whttp://ec.europa.eu/enterprise/sectors/pharmaceuticals/documents/eudralex/index_en.htmz MP5Zhttp://esubmission.ema.europa.eu/doc/eCTD Guidance Document 1.0 FINAL FOR PUBLICATION.pdfz <.z _Toc255322994<(z _Toc255322993<"z _Toc255322992<z _Toc255322991<z _Toc255322990<z _Toc255322989< z _Toc255322988<z _Toc255322987<z _Toc255322986<z _Toc255322985<z _Toc255322984<z _Toc255322983<z _Toc255322982<z _Toc255322981<z _Toc255322980<z _Toc255322979<z _Toc255322978<z _Toc255322977<z _Toc255322976<z _Toc255322975<z _Toc255322974<322964 _Toc255322965 _Toc224630266 _Toc226191769 _Toc255322966 _Toc224630264 _Toc226191767 _Toc255322967 _Hlt217710261 _Hlt217710262 _Hlt251141762 _Toc252728426 _Toc252728590 _Toc252729047 _Toc451062386 _Toc452788157 _Toc226191770 _Toc255322968 _Hlt256512538 _Hlt256512539 _Hlt251141827 _Hlt217712908 _Hlt217712909 _Toc224630268 _Toc226191648 _Toc226191771 _Toc226192021 _Toc226193136 _Toc255322969 _Toc255322970 _Toc451062387 _Toc452788158 _Toc255322971 _Toc451062388 _Toc452788159 _Toc255322972 _Toc452788160 _^A 666666666vvvvvvvvv666666>6666666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~_HmHnHsHtHD`D NormalCJOJQJ_HmH sH tHJ@J @ Rubrik 1,H4$@&5CJ mHsHuB@B ?I&Rubrik 2 $ $@& 5CJaJJ@J ^jRubrik 3$ & F @&5aJB@B CRubrik 4$@&5CJmHsHLL Rubrik 5$@&5CJOJQJmHsHuP@P  Rubrik 6,H1$@&CJ OJQJmHsHuFF Rubrik 7$$@&a$5mHsHuNN Rubrik 8$$@&a$56CJ(mHsHu: : Rubrik 9 $@&5CJJA`J StandardstycketeckensnittXi@X  Normal tabell :V 44 la 0k 0 Ingen lista 8@8 Sidhuvud  9r 4 @4 Sidfot  9r N>@N Rubrik$ a$CJOJQJmHsHuDB@"D BrdtextCJOJQJmHsHuHP2H Brdtext 2CJOJQJmHsHu0U@A0 0 Hyperlnk>*B*N@Nthp Innehll 1 ! xx5mHnHu@@@ p Innehll 2 ^5CJH@H \(p Innehll 3 (!@ ^CJP@P bp Innehll 4 ! ^ CJOJQJDD  Innehll 5 ^ CJOJQJDD  Innehll 6 ^ CJOJQJDD  Innehll 7 ^ CJOJQJDD  Innehll 8 ^ CJOJQJDD  Innehll 9 ^ CJOJQJ: : Index 1^`: : Index 2^`: : Index 3 ^`: : Index 4!^`:: Index 5"^`:: Index 6#^`:: Index 7$^`:: Index 8%^`:: Index 9&p^p`2!2  Indexrubrik'<V< AnvndHyperlnk>*B* *)@* SidnummerTQT Brdtext 3*$d%d&d'd mHsHu66  Fotnotstext+CJ:&: FotnotsreferensH*@'@ KommentarsreferensCJ6@6 9 Kommentarer.CJ>K> Inledning/CJmHsHuHYH Dokumentversikt0-D OJQJFF r Ballongtext1CJOJQJ^JaJ:+": [ Slutkommentar2CJH*1H [SlutkommentarsreferensH*boBb ggDefault 47$8$H$-B*CJOJQJ^J_HaJmHphsHtHbRb ia table text5(*$1$$CJOJPJQJ^JaJmH sH tHncn i Tabellrutnt7:V606*(q* #| Radnummer>j> $xdKommentarsmne85\LL .$xdKommentarer CharOJQJmH sH tH>> 8$xdKommentarsmne Char2/2 -# WW8Num4z0OJQJDD ^j Rubrik 31<$ @&5aJ@!@ yFormatvorlage1 = & FF;@F |Numrerad lista 3 > & Fm$VV I& Rubrik 2 Char#5CJOJQJ_HaJmH sH tHbOb XRubrik 1 Char,H4 Char5CJ OJQJ_HmHsHtHPK![Content_Types].xmlj0Eжr(΢Iw},-j4 wP-t#bΙ{UTU^hd}㨫)*1P' ^W0)T9<l#$yi};~@(Hu* Dנz/0ǰ $ X3aZ,D0j~3߶b~i>3\`?/[G\!-Rk.sԻ..a濭?PK!֧6 _rels/.relsj0 }Q%v/C/}(h"O = C?hv=Ʌ%[xp{۵_Pѣ<1H0ORBdJE4b$q_6LR7`0̞O,En7Lib/SeеPK!kytheme/theme/themeManager.xml M @}w7c(EbˮCAǠҟ7՛K Y, e.|,H,lxɴIsQ}#Ր ֵ+!,^$j=GW)E+& 8PK!ܪ Otheme/theme/theme1.xmlYMoE#F{oc'vGuرHF[xw;jf7q7J\ʯ AxgfwIFPA}H1^3tHyH >͙85BNe tY1?C K/^|Kx=#bjmo>]F,"BFVzn^3`ե̳_wr%:ϻ[k.eNVi2],S_sjcs7f W+Ն7`g ȘJj|l(KD-ʵ dXiJ؇$x$(:7vɗsKZj{ b_=<;~Ç~me~Oyj,_~3SŗO~{Wݣ 2|Hc"Mry 80´L'XKS9,G#}TO9 "1QBN;]YJ/hY%7'IX-\Lʸ}dwqķ7IoiލÉ!IB? º:~ݥKQJ ɦ6!.*!ގovgUVoC UYC7^*Co`U)9 I )hn  2lHA2rt#UM2y)WU]V~8daPnpJo&BZӁc];f́k_|"F {RU%lhp'n=w O=i>kZov[fDNc@M!͐,a'4Y_wp >*D8i&X\,Wxҕ=6.^ۄ Z *lJ~auԙՍj9 !bM@-U8kp0vbp!H#m|&HyȝC)^+Ikio ,A*k,GMg,JnO#KtZ妇|1ikBԥ0 ^W¦l|Vn[u~3j ȦyK$rzQL -V 5-nhxL|UviE>fO(8B#6¯S ܣioWnsΊ|{epv4Y%W:.t0O%Jݍq7ŔRN)z?@G[\׶Dž8t4~_`zd kH*K69mYiHE=hK&NaV.˒eLFԕU{D vEꦛdmNU(CNޜR콶3a3/TU-!޲!ljUJ[A++T[Xs/7s b1p߃1i7!߇ފ  !!$fs=x x Ox x x +; $ ( j R}$cQi9AK{"&(C+/1K58j:%>@AEG{KPTWX<]behYjnwI2Ī}ƶJdOASorstuvwxyz|}~8Lj*Dd' %w18JAFP Y`vj_vk|~RV݂ zT aʆ3Ṙ#KwΈAp߉MtŠ2H`v`>SmōU4N6g'gב<j.]bڔ=k̕y3QAoKwΙ+fӚD${˜P%_)s,zߠT١^ޢLNLեbP${,F Bpê*y(M}/U!V߮/lį.Xs@Yı@IJٲ)A[г.Gl4Rص &?]vĶݶ*C\uշ Ohظ #Ib{й#>_Ժ -HcHc~Ӽ $ʽ -Hc˾!<]xο>PbtLe~Kn$Lt>gZHt$Q~/[@Y1Jc >WPi$GnCoAt;X6#Mu 4Yzc#^4{,pq{      !"#$%&'()*+,-./012345679:;<=>?@ABCDEFGHIJKMNOPQRSTUVWXYZ[\]^_`abcdefghiklmnopqrstuvwxyz{|}~      !"#$%&'()+,-./0123456789:;<=>?@ABCEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcefghijklmnopqrstuvwxyz{|}~Qij%?[]^`(?[]^`   .Lhjkm "Bj4PRSUu(<XZ[]}%7SUVXx  . H d f g i  9 ; < > ^  6 R T U W w   0 K g i j l  : < = ? _ %e&BDEGg'Kgjkm6RUVXx9C_bce'CFGIis*Tt !'!(()1111i2~2%6669+9G9O999o???h@@@BBB2GVGmGHI9IPMMMPPPVVW[[[\\]]]]6_w_{____ a3aOaa7bPbTc|cc X%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%tX%t̕XXXXXXXXXXXXXXXXXXXXXXXXX $'!!!$:t  ,2$]߿p|!y@ (  b  S A ?#" ?B S  ?H0(  T,*B4 OLE_LINK1 OLE_LINK2 _Toc452788143 _Toc181696660 _Toc255322944 _Toc451062374 _Toc452788144 _Toc255322945 _Hlt252683995 _Hlt252683996 _Hlt251137597 _Hlt251137598 _Toc255322946 _Toc451062375 _Toc452788145 _Toc255322947 _Toc451062376 _Toc452788146 _Toc255322948 _Toc255322949 _Toc451062377 _Toc452788147 _Toc255322950 _Toc451062378 _Toc452788148 _Toc251147201 _Toc251147624 _Toc251147771 _Toc251147825 _Toc251147880 _Toc224630249 _Toc226191752 _Toc255322951 _Toc255322952 _Hlt181431469 _Hlt181431470 _Hlt183410300 _Hlt183410301 _Hlt181433518 _Hlt181433519 _Hlt181591934 _Hlt18159Toc255322973 _Toc451062389 _Toc452788161 _Toc224630273 _Toc226191776 _Toc255322974 _Toc451062390 _Toc452788162 _Toc224630274 _Toc226191777 _Toc255322975 _Toc255322976 _Hlt217718689 _Hlt251142763 _Toc224630276 _Toc226191649 _Toc226191779 _Toc226192022 _Toc226193137 _Toc252728436 _Toc252728600 _Toc252729057 _Toc255322977 _Toc255322978 _Toc255322979 _Toc255322980 _Toc255322981_1._New_applications_1.1_Acceptable_dossier _Toc255322982 _1._General _Toc255322983 _Toc255322984 _Toc255322985 _Toc255322986 _Toc255322987 _Module_1_Annex_2_Example _Toc255322988 _Module_1_1 _Module_4_1 _Module_5 _Module_2 _Module_3 _Module_4 _Toc255322989 _Module_1_2 _Toc187650015 _Toc187650016 _Module_2_1 _Toc254797159 _Toc255322990 _Toc187650017 _Toc187650018 _Toc187650019 _Module_3_1 _Toc254797160 _Toc255322991 _Toc187650020 _Toc187650021 _Toc187650022 _Hlt182113948 _Hlt182113949 _Module_4_2 _Toc254797161 _Toc255322992 _Module_5_1 _Toc254797162 _Toc255322993 _Toc25045728 _Toc181696655 _Toc255322994 _Toc25045729 _Toc22356220 _Toc25045730 _Toc22356221 _Toc25045731 _1203420911 GII...889XXXXYYYY`d d e e o $$)))W,N-N-N-N-N-N-000000000000001333555666666@8::;;;;;;`<?AAACCC]G]GjGGGGGGGGIII%I%I"K"K"K"K"K"K?KVKLLMMM8O8OPPPPPWWWWW]Y[[R]R]R]R]R]R]R]R]R]_`Tbxdfffffh-nsw=x>x>xcxcxcxcxcxcx9{BCjُБББ{՘vvvee``@ @ @ @ UV @!@"@#@$@%@&@'@(@)@*@+@,@-@./0@1@2@3456789:;<=>?@AOPQRSBC@DEFGHIJ@K@L@M@N@TWXYZ[\]^_`abcdefgh@i@j@klm{|nop@q@r@s@t@uvwxyz}~@@@@@ZZJP,777RYYYYZZZZae e f f p $'$)))k,p-p-p-p-p-p-000000000133355566666666666F8F8R8::;;;;;;i<?AAACCC^G^GkGGGGHHII I&I&I=K=K=K=K=K=KNKNKUK7L7L7LMMMMOMO Q Q QWW+W+W+WYYY[[R]R]R]n]n]n]n]n]n]`D`ubdfffffh]nsw=x>xaxcxcxcxcxcxcxA{Bio؏ޏБؑؑԘޘ v~~nnll '|'9'$'t69'[8'\r9'4V''$@#'9'<~9'\9'$','$|8'\$'9@'     ''F- 8*urn:schemas-microsoft-com:office:smarttagsdate;*urn:schemas-microsoft-com:office:smarttagsaddress:*urn:schemas-microsoft-com:office:smarttagsStreet 8 11620012002200337DayMonthYear         !!/52577|CC?KFKOKUK8ONOP QW,WR]o]nnRT~Հ׀HJwyǁɁ?JKRU`njь OZ[bep#I\ǒ':`sœؓ\o 3Fŕؕ@SЖ Tgޗ"[nӘ 0Lr͙ 6RtҚ$@m͛&B|ۜ$@c˝ :V՞(D{ğSoݠ  @Jiryak}/7qzl|Ϭ,1"n| ( ?KUK8OMOP QW+WR]n]``efandnss 333330Q ,!$6$W,l,N-q-0066@8S8::;;k??AABCCCGH"KVK8ONOP QV,WWW]YYR]o]Tbvb@ccxddhhktuvv zzIz {9{B{{{{{{J|V|||}}}}~0~V~c~~~(Y|%EMqyȀЀ;Cjr}ރ Zb݄FS|;c.a(XՍ'q-ېړ/q֔[4i|ė7p՘ N"TԚBWDYB͝#XmŞFY/qߠ"Oߡ5oƣ%^aͩ8I{[~ͯʲ˳ɴ/ĸչCRb8b)l6%HqCl3a=~e5R} ,<=8;GG (!12#k\/ v~@>~>I1̮*?+=S!w pR 48~vxAm L.S%ΈhD%Ⱥ)q&z*KV%K2̃Q3KJs4e7KF8Vvx< <^0}=HpzzQLs.%AS zaS("8:bCf4]pb4\nms[ravppCJ{̚Dq}`^`.^`^`^`^`^`^`^`^`^`^`OJQJhh^h`OJQJo(hHk^`ko(.0eke^e`ko(.p0p^p`0o(..@ 0@ ^@ `0o(... 0^`0o( .... HH^H`o( ..... ^`o( ...... P`P^P``o(.......  ` ^ ``o(........hh^h`OJQJo(hHh^h`o(.z^`zo(.0^`0o(..8^8`o(... 8^8`o( .... `^``o( ..... `^``o( ...... ^`o(....... ^`o(........ hh^h`OJQJo(^`. ^`hH. pLp^p`LhH. @ @ ^@ `hH. ^`hH. L^`LhH. ^`hH. ^`hH. PLP^P`LhH.h^h`o(.z^`zo(.0^`0o(..8^8`o(... 8^8`o( .... `^``o( ..... `^``o( ...... ^`o(....... ^`o(........hh^h`OJQJo(hHhh^h`OJQJo(hHhh^h`OJQJo(hH^`OJPJQJ^Jo(-^`OJQJ^Jo(hHop^p`OJQJo(hH@ ^@ `OJQJo(hH^`OJQJ^Jo(hHo^`OJQJo(hH^`OJQJo(hH^`OJQJ^Jo(hHoP^P`OJQJo(hHh^h`o(. 8^8`hH. L^`LhH.  ^ `hH.  ^ `hH. xL^x`LhH. H^H`hH. ^`hH. L^`LhH.>^`>o(>^`>o(.0^`0o(..0^`0o(... 88^8`o( .... 88^8`o( ..... `^``o( ...... `^``o(....... ^`o(........^`. ^`hH. pLp^p`LhH. @ @ ^@ `hH. ^`hH. L^`LhH. ^`hH. ^`hH. PLP^P`LhH.h^h`o(.z^`zo(.0^`0o(..8^8`o(... 8^8`o( .... `^``o( ..... `^``o( ...... ^`o(....... ^`o(........^`. ^`hH. pLp^p`LhH. @ @ ^@ `hH. ^`hH. L^`LhH. ^`hH. ^`hH. PLP^P`LhH.hh^h`o(hh^h`o(.0^`0o(..88^8`o(... 88^8`o( .... `^``o( ..... `^``o( ...... ^`o(....... ^`o(........hh^h`OJQJo(hHh^h`o(.z^`zo(.0^`0o(..8^8`o(... 8^8`o( .... `^``o( ..... `^``o( ...... ^`o(....... ^`o(........hh^h`OJQJo(hHhh^h`o(hh^h`o(.0^`0o(..0^`0o(... 0^`0o( .... 88^8`o( ..... 88^8`o( ...... `^``o(....... `^``o(........ hh^h`OJQJo(hh^h`o(hh^h`o(.0^`0o(..88^8`o(... 88^8`o( .... `^``o( ..... `^``o( ...... ^`o(....... ^`o(........h^`o(. ^`hH. pLp^p`LhH. @ @ ^@ `hH. ^`hH. L^`LhH. ^`hH. ^`hH. PLP^P`LhH.>^`>o(>^`>o(.0^`0o(..0^`0o(... 88^8`o( .... 88^8`o( ..... `^``o( ...... `^``o(....... ^`o(........hh^h`OJQJo(hHhh^h`OJQJo(hH^`OJQJ^Jo(hHopp^p`OJQJo(hH@ @ ^@ `OJQJo(hH^`OJQJ^Jo(hHo^`OJQJo(hH^`OJQJo(hH^`OJQJ^Jo(hHoPP^P`OJQJo(hHhh^h`OJQJo(hH^`OJQJ^Jo(hHopp^p`OJQJo(hH@ @ ^@ `OJQJo(hH^`OJQJ^Jo(hHo^`OJQJo(hH^`OJQJo(hH^`OJQJ^Jo(hHoPP^P`OJQJo(hH&pR.%ASQL1S!w k\b4\nx< <S%av+hD%Am~HJ{Dq}vxvx~z*48Q3=e7Js40}=%K2msF8q&%K2@F1 zaS:bCf:bCf:bCfXbScTf$@CX#OutlineWW8Num5#n5jINj                 @ @@ @H[,upB#JA+I&f 9HnLkH 8CzJ4Gcf"1mr|1TYwlG  > M i JQ Dm ev   : X \ Mm o Z g -C  +2/[Ln^t h[1w6N 9<WZ9fm q}qO /{2gx(m n'$xz4y ==DhWQfm/Jz  K !D!) "#$#-#$o$=$U$pj$4%%+Q%S%q%&&*&k& '('>'vX']'r'(V#(\(-V)%*x3* \*'_*+(++7+xA+S+g+2,b@,y,|,*-@-8y-c.!.c.fj.#0LU0%1{a1Z 2!2.2822D2m2M33@=3h3j3O"4J4K{4B5S5k)6o677@7H7Q8D999999W<9: U:fi:;M*;;!"<md<==#:=J=\=j=dp=> >?g?3h?@0@B@e@ $A]?AJA\AB!,BTBqBCV;CzQE&REpEF'FJGxSGXGaGiG`rGH&H?HHOHTHfHHXIJ 1J4J9J8FJMJZ\JJKbKeKrKgsKOLQLM,M MX%M%MfnDY(N"Qs xmX8RU mUes7O%\Xsrxcf670D#*\KTX_s|VmmBT(tBe?j.%_qr0cb vCX ]xS+=>b,0=e|&)r\w B,>\p-%18ug04Y[2W"}""t^ -es#*7. 56ql9r?bekNca*SX~a) m%mTrN:ethCFySV>x 6"P/K0X^ #LL{)@khTxs"yy#Gdny G7AXCTB`a|iF2R <=z(|TJ elv9&X 0uF x+=RUVbb vW^]uB#olv (6QSl  E"\Nmnuq{C/, >0NNUTiw0:_@cbxW2Cs h(w:rb[d@ `@Unknown Klaus Menges G* Times New Roman5Symbol3. * Arial7.{ @Calibri5. *aTahoma[ ThorndaleTimes New RomaneAndale Sans UITimes New Roman;Wingdings?= * Courier NewA BCambria Math"1hxxƯF!kl|!kl|3x4d- 2qXZ [Yx2! xxNees eGuidance DocumentDavid Wheeler for Topic Groupkarin grndahl#                           ! " CompObj.y