ࡱ> }|'`bjbjLULU ..?.?  JI( (P P P  HHHHHHH$JhTMbHn n n HP  I n P  H n H NOCWEP  S .D0HI0JI'E0MN M`WEWENMH$ 0' " I e  HHj  JIn n n n d CaffeineChemistry What Is Caffeine and How Does It Work? By  HYPERLINK "http://chemistry.about.com/bio/Anne-Marie-Helmenstine-Ph-D-7815.htm" Anne Marie Helmenstine, Ph.D., About.com Guide  INCLUDEPICTURE "http://0.tqn.com/d/chemistry/1/G/0/g/3dcaffeine.jpg" \* MERGEFORMATINET  Space-filling model of caffeine. Caffeine (C8H10N4O2) is the common name for trimethylxanthine (systematic name is 1,3,7-trimethylxanthine or 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione). The chemical is also known as coffeine, theine, mateine, guaranine, or methyltheobromine. Caffeine is naturally produced by several plants, including coffee beans, guarana, yerba mat, cacao beans, and tea. For the plants, caffeine acts as a natural pesticide. It paralyzes and kills insects that attempt to feed on the plants. The molecule was first isolated by the German chemist Friedrich Ferdinand Runge in 1819. When purified, caffeine is an intensely bitter white powder. It is added to colas and other soft drinks to impart a pleasing bitter note. However, caffeine is also an addictive stimulant. In humans, it stimulates the central nervous system, heart rate, and respiration, has psychotropic (mood altering) properties, and acts as a mild diuretic. A normal dose of caffeine is generally considered to be 100 mg, which is roughly the amount found in a cup of coffee. However, more than half of all American adults consume more than 300 mg of caffeine every day, which makes it America's most popular drug. Caffeine is generally consumed in coffee, cola, chocolate, and tea, although it is also available over-the-counter as a stimulant. Caffeine is believed to work by blocking adenosine receptors in the brain and other organs. This reduces the ability of adenosine to bind to the receptors, which would slow down cellular activity. The stimulated nerve cells release the hormone epinephrine (adrenaline), which increases heart rate, blood pressure, and blood flow to muscles, decreases blood flow to the skin and organs, and causes the liver to release glucose. Caffeine also increases levels of the neurotransmitter dopamine. Caffeine is quickly and completely removed from the brain. Its effects are short-lived and it tends not to negatively affect concentration or higher brain functions. However, continued exposure to caffeine leads to developing a tolerance to it. Tolerance causes the body to become sensitized to adenosine, so withdrawal causes blood pressure to drop, which can result in a headache and other symptoms. Too much caffeine can result in caffeine intoxication, which is characterized by nervousness, excitement, increased urination, insomnia, flushed face, cold hands/feet, intestinal complaints, and sometimes hallucinations. Some people experience the symptoms of caffeine intoxication after ingesting as little as 250 mg per day. The lethal ingested dose, for an adult person, is estimated to be 13-19 grams. While generally considered safe for people, caffeine can be very toxic to household pets, such as dogs, horses, or parrots. Caffeine intake has been demonstrated to reduce the risk of type II diabetes mellitus. In addition to use as a stimulant and flavoring agent, caffeine is included in many over-the-counter headache remedies. :=>   ? Ǯ{aLaL31h@Rh@RB*CJOJQJ^JaJmH ph}}}sH )h@Rh@RB*CJOJQJ^JaJph}}}2jh@Rh@RB*CJOJQJU^JaJph}}}1h@Rh@RB*CJOJQJ^JaJmH ph3fsH 2jh@Rh@RB*CJOJQJU^JaJphMJB1h@Rh@RB*CJOJQJ^JaJmH phMJBsH (h@Rh@RCJOJQJ^JaJmH sH  h@Rh@ROJQJ^JmH sH $h@Rh@R0JOJQJ^JmH sH : ? @ A ]Idhh-DM gd@Rd-DM gd@Rd-DM gd@Rddd-DM [$\$gd@Rd-DM gd@Rd-DM gd@R ? A L M N P Q R S T ʯʯʯʯ4h@Rh@RB*CJH*OJQJ^JaJmH ph333sH 1h@Rh@RB*CJOJQJ^JaJmH ph333sH 7h@Rh@R5B*CJOJQJ\^JaJmH phfsH  ,1h. A!"#$% [fDd,,  S vAB3dcaffeineSpace-filling model of caffeine.bmej9“3|NIeDnAej9“3|NPNG  IHDRz pHYsHHFk> vpAgdkIDATxxUWӡ6i)(V D$HM$@\=@pwmz uP6Й>c=ͽ眻.{rn--nܖ_Wn|moq -.#7#7;:~_Ln}A 8?wxC}+,??3glݺuƌ))) ,عs/w_>K5ϥv+ض?k֬m>UVmҤwvxuww[nڵ5jTD|*P@…yݻ?(#r ,|]XVZ͞=s\ }G3fLÆ UFܹs@@@.]A@~w{>>>k֬/… YYYQQQC ܵk{gз0 ^`A{r'OLNN /?Ch5piΝ `| WXp·~;4[wZ0sO>~7|Ç>Ejo$v_) pB-?ׁ_ 05fZ]AӀ@3G͇˔)}  ) ŋ9C,0wyE `HtR(η"duX$&z7;\r(-hӒ%K -NCCq3yFnԮ|>|Q  ^rEf3L/"ׯ_axw}oO4<H0Hc9u#]+lMD/h7 KшK&ޅX>' 6^o"Z?SNNL/Pyɒ%Ϛ5;)]:Q'N\2xoH?0j#Vb'0-f]ҥK Q̸Zt@gΜuZ}W3_}.V?}tǎ#""rL۴`vvڛ6m½0J)XiKNH3v /Wfl]`WN]':B9C_@}`PlݺuogŭW^jj* t gF>5p !E 0`;aѣGo>g]p!6fdd= >!h.._yCرsWzu V3޽Zj0v `gˉEV- '+ab  eAwsL:ϋ(}΁f`wDnzbb"-s*r'+44 l$D%R.(cǎ}ڴi@3C}%~ 'aM,+jb, A.6k(1ERhW;#,;eʔɓ'f||<@=ank. dНix|>Ǖc5k(?6RtdɒP ` c8C<)]G.I&-Fx= -T< 9v⚉E~XK M ͬ4_v`PFIK ?`-9T$L,$8f8Yh&(el˷ʁVa"L͚5+TH[ӨQMk7lѾ}xd䜅 aw_0`rhhenh`d H3ѣA76665啮@gDG铋nbJ׫MOkdǎ/vJίuf@{AAV@ہW[Z `C\tlfhݺ%Ξ}n۶ٳ۶}e˧6]߰ի^i'njY׵Rjb&"~:Wiܸ1X3?(X4-&0R%;q-pLժk[`իBߖ-[)]T )^|d٭[3>r!,안bc1ʈ v5&ZT]=z\-KEc_iSa衷x#UFK@)Ѝ]xpt.\9}߳۽{A?ۼ*dž Zƒ%/ϝ̌Ґxet>Sw=$&&ӧnݺj0ܹ3i@2Hff&/4‚x.@ #pq.7,,,((m۶f͚˕Cŋ^=e˝|}>rTa?ĉW&L6~Ց#|y5<]an/XC_xݏkwcw,eX*t wq.h|{ہ<݁ݟmvm֮}kٲWpg: Y&l=zmd䬞=ƴm'""&.E:Wou BBB@_ !4z[BhQ!%DC ] w1\t " 4qwoQJo4=ӥ={ѤIWҮ'%]>|?Þ=?=EF@F?_ Dǎ||v谨Y3paM+_`[ @<=nbǎ1E>/cǾ=rÇ>'/s9&東c32><㔔veygwBC2 }~~s3:97n|wv-Sٱc%9y7nx(hݻ({N̙oĉtk7nݛ+Vxs>=}-Z#9<|̔)'OIOOOKK#fhEMͽ<:ݫO} П8j{c}uh.m~}s<5sɓ&&7nða6dH̙՚U`Thǎ[l?s瞁BBzǎCF  ((_AQaazԻ^FGZȉM[rm3;?rޗ"#ߌ}wԨƏ(>j\GF}8d{}ӫ[o_ }X_>s"˕+Vw~sW[/nѦM@͛?9>B߳g=wg>u꫓'8|{7lxgժKb0ԩ{GX9p B6oFf8h4_{FD0`zDČEFN4hN}p &w{wﷺuK{8/tkw뀗<^ܴi>7SFKW*:w裍e׬ywƫٹm=oǍj>Tǎ}}7N}s=ѣw m~?k 1V|aVЪ/_ Fܚ!1P11 bba [F3fرY(z96mNNS7Y4i'M*3sVjZkd޼s94-$^T{pާ[z٭A DvGyy./ܦu`XO<$ ]ݕ+- xO8پ;سm>v+|'scǾ8p]܉bwWt ~ӄ [&LLHK]0 8oi9Lz׭];fee9#^hNRaӾ/Zuw7 ˅Gˡ_ |Ձ+L G!..Zpv5;l_<zm>>'5%/Xqiw֭{?+uރ[~}g;w~NȻog~~yN{ufl{kּbDô5 q?z)SٛmffN41eJqlXX̐!vر6"'GbN4?CdKKⷿpԩ׭[y[rSn'W^m1`ưub@+zvv hCB^ zur.]ʱZEGXӶ6mkY@ SO:?`ʹb_|A > ˲eˡSf枹s,_of5oɖ-;v|k'{|w/jOvxǎ۷6EX gf> Ǎ۸h[7o߾cv^ _7nLlѣ׃ [`LH=iA@=…/,^|=/~sn7 0xgg:vdRp*ə@9 nŋWl{uEX?Qُa}UÓ_?ׯ_gx //Qo YY>oA/a9;8 {f^^C(}hw\b{|;eLyY'Z!*t8VON~j'M: oPGuINHB/'9ӏOae\JQTX5Qc_&Oݳg?Ɔ\s0?ggt/3 }4== 4rD\T)<[GZneffFfkqG0zyPetBdwq[\߲%rs9n\ lrÆ ?#רdj=SH`E4nڵ?35Q8_+V\0'd+B'8B?:u)V2 c|ZgYM6;#o Pʂ4|g'O>-XD'AS. Δ.EZlhgΚA.hO\j(c_۶w.袖ZXg\ݢşgg\+jݺu۶mW8p5|)~kN娚EuѢ=3f<.Ub-Z&a4>6e]3g`mq+]̰1c&Vj:c@'{tG](P mu,}ƌQQZ>d1o'K!6mpvCjYmтPPƟ˗/8X]#::XuqvCl;&,*ꠋ[H4?t]-Y}ڴS*cO{QT4kaz͜ϝs7F&{=3228CN2=S҇Mt(5@B32.\`{l'q.[ M:5%)iCv<<z y=`ryR[=<6hk]i[t+\KTV#.D(WP#G?c٥"fe˲N=6cƹLBR|k99o4 LӟI&&KM]=gƤZ\);%ӦMKOOOL8~|J\ĝIIyMLܕرl̙=f(mM:V.'F)II 43̑ݪF9_cY%Mr,5 K5[i^ѢE~7a#G,_ڵ]vVJVEU[*ch(1NTYȬٲ~%&rʔ))&O>q bYx]twe„ٴ;m.8dY-Ș4iRRRr\ܘ#L"m[Ǐ5*k̘y(so]ǾI! ׍&N5~|F+5Zi.S5[Ԥɂ&M7nvX(z@ݝʥwU4vѵwРA{%?=<|CƏ`vҽ_nPͭ4V1"z{yZu\Zq5kת5V5Ԩ1Zի^}t#UhRP"/] |…RJ=3*Te@TG[8W03?W"c{NũIĉ)Çω]nQQs##ǎH-@  mzJrJ,AAzD 9z43x$3rŚsf.:"B} ]{XCU^ЪUTT`s X1bŘ*Uz/[ ^4>壶*Q ^xU%T*"rڀ"Q!= -vlj|@< 13*jNTԬ}FE=zd\\0VBi>Vg ]-2^zz{ 40@M8Q fs{ uD\]I?woʗTO ˗Yʗ-[{r-ͭ431OX+B f'oMA jOrMM[?^;*0$=2<TZ .+X#WVV״,Hi)۴h֬)=nݺ7i֭3k3`M4_ ,O{=@v'|R=U VF*- B\v)Պfg$Qkh&nyzzb,x+4=mDK?W׮W&N#3iP۰ar9F|F7\gKԱx rӁtХv^V4i٨QCkPPwE^_'YXߵk&FxӦM[gx gXJ"-!5B3is-9uն# 6TEL1hJؠ;yEhdJQVN3̈JmEZMCӲfvޣw0YetX:Y'>{Lݎx\gЫW:P7"젠!ݺ ؕ#ɉhuVda7o NtP yB`>KoBj"褑Ǐ ]*رC Bg,M\^vȎB(e `bh5}4Gis4ʭ,ed?i Ղ&Mzzz <-,'?42*jpTFwdtt\llСÇg:wE#F1bUlaa遁t()xZ[… @СCX("(09rD9I!0Ў.9pȭsBjU@ۮw@@WEƢ+j)Q`;  VW<4,_߾)cc>{ԨyqqKW%'IIY}֬s瞘; Z 3G/-\Ҽy/df>=c٩SO,cf 47..xZ$C(j7[ډ@(s74LCaPkSʎv9Q--\$\84oqѤ+t5Jz ԣGСIAN$ְFF5P t۬Kb %nq O@7d"=y[U.Y5o]fV&;m_˗t&WEW3䎧1c6͟;7'ᑶmД&@ 1r5}Jc":bŊtӜ80 5j3ۦjtmIH:Gk'D#MvG@vD8 ]|~M{,!a5voxS-3%ҰoUiK{[-ǟ&TK5F}SFƉ3N͙G/]寬Xʕ^}i˫V]XҊk˒%0I~jܕ9֕+Wh@` +;jYy "1g%J?HU)EZ(X ,էW-6siTs-?c~c+.?y)S%&1b^pv6MQph043 N}2L< m%lgxLG$\QOyѢ< ":-U;EZs)7l%HP'𞑑׬l,z299͊~%; B<6)N YkC؎kj6.M;&,~,{5K~;Y'M:4~cW_q D. iޥE `Iw!=$&!#%AW,]Q 4*Raj'Mi2FifM;,3bmetփ M92uٲgX+_] _LOǡKs.kLdvdjGZ[c'*%Aß)Akc3;E.uS+V\W˦?ousob5؂WF ]PQtsW[`j \`F-\>ӡ4Z;+?"P5eU.5ٿ_RVͫU^7e^>0(5sN`hfX]<,THk/j˗/VX׮]ie5"DJjX؎Tvl9(\DG<~[@nks /}DgBsƁ3t WKl,T@,';x]Y3g> ZfjKZv&]`rQ-\[@˦ FP6l^=5iT>;]7]n+so`-PEmذapp02HҫQ38hਨ;s֮}c͚֭{PGt~SR:μeg&͆tQ#6ZZb9Z<ո{f8uZ^ۥEv]Pii{ܸii+6@_T+ĔZ^Y-h<['K[Xqvڅcluz;ݻwÿ kրT}@WAfORR6RX֬A9b>5͘7]DUʦ3Xq4'sL޾f8v-`++r LOO=iais,.Cfŋ^ b1i:W6Xɖ]eGI9݀KĢUTqg]up *w}f}mXlkFF202r@>a11'@ "K_l[Rt]gyY,ʸ?wc 4N\X㩩OLvRyZ]A' 5CWS/V a!Tf0Vu=?^3ڭMk,0W_QҪU@jMD1u۪FTHT"_ YJz8,9ThU_ X١1gڳ3ǺQ ɼ6!h\#1q}z)SզO .粻)){#>~…󔽤N{WQ1v_kM&_\D?}0!t-0.SL|cH%8ׯJ>:C6yI=ziΜg䰘௹փ_2Bvn>LbbV|8̅(ڍD\떗;/H8Sb_r34)!a;4NYz.JJړ#.nѫMxB뇇SOb/^-mx AyUvwr˷0U ]9q,.__ҝ0i#GU$44K <839yQ%#0dG {p> LK7v,!ل$l4^fcg]pxߙ%v5M6Rm~3oR! O kEbv{cJkU|(СCoe1&*Gcw;ȟ? _Ν;00WlԩSHHSRpEbnS;YQ2pCW y36Yzd̘)cǎR䭡;fss@TA_[c#y֝Ym]G+Ї&L _0q".,qY{Di Gb&EntPFTsR5d)FB2E:M: H$A8xUV͛jϯ[XXBtaVP X14`?ҵxRСQ>D,3&nV]3.Nmsˏ;nԨeqq['Ln7$%%o60)JXl\Wx]܈[6dufҥ.\`ʕsww_~:u7n?Oi΍?vl)ʁ**~I37u#(1cDG!K fg[Iwj7*?*Rju)sXb\ܸa rܸ cncǦM2]<`h\{ ~6p&|EkKjMɫ6l)XҎ_=jժi_'G)2X:7Ǔ3ucƣ BPD !>;g&iLPA__)y2>ɥ;j#?daÖ :x𢘘Iz|u)"jc )kGk\}|RRvrifՒ>IzJ?`ٲe Ў8/aaaUvq':zƏߖ/=H}0C>T\qP<BL)dž~ʵh()6UtxdžX<1*fمk܋?22ycb^ЯpG?hT'x lRݶyֈݿ)Sȑ#]RJݸX~ (Ws3(af(榧/0a]|Ľ8xq-?Bdǒ]W5hЬܵz AZcgvLk1QNpNI99d|ZlId\l0iye 4 @_va-ux?;;[Oj1@*W W[Dj[~bs~lҍ֮] ;`>0ke`QD¶ЁʟZn 5IK4cr e =fyf 8LرM1yݻիvg1%aN]D'i<}"::o`ШCc0X]ץUFyr& WߨEDF4~ 'l9ZjaV4G[@QPYʢnݺm[޾mۖU6L&.nͨQYcnۢf&nQ֎J  ꪀ[{k2mbG`ŹTP!DSm8 }$ m۶a#`V):v0*"F0Q2Te1;R0AMq)V؍G,m֭_9g(9Ł_a3.pU}y%[nϞ;wn剉KG\:dȊaVr(_9*0p?{q&޽{^SHkBeL s;] 3Ӯqz_FNnJpM#0.+\TH^՛ns:Khܸ1=8nv>8l,3I+]li&MdVev~U,iisF='2rNT<37h>),,GD_@P!3`ݵ 4FUVt6?вͮת_rQ]N`OOOnD.vu^V]MIK3M%e8_mzD3]R*[J(qߔ޹r9vJp[AiblUMT[II2*Lэk*Wfԩ'L;o=9R')ح[|HH\ǎ=v۹sgQAӠ `bL͎q:=m&gv !-Q*.:28u|}#۷۠AMm۶f"-K uMxȍo_Mq蘆4`VܥE=꺑!:}I% TBT58NիWREsnMeUИO?Tռi4ji<a੫n5bg--tTx8~ὺtӼyFZTTr 4 f///o۴i#QZ쫭َey3[A]m7oޡCج.]$VJfXm+ydhf|ffo `}TMٹR4Epp!MZEFD\3W4 9>38Ҕ^:򵅻5jxG~a@:5:qa!4zKLmڦXdKl3{Pj3 XP&MrN%>pM޴&V/~[^Tڵ{kץ !T?Z?22ևd m0ۮ ݕ9!?]xOZk.xyjB[`ڷo5bWs[ @FT]-`{"4T '8 > 3K5kՌ.FT Oc ryu/x Cwy^xgΜ9*jWz4'/(P@;U@"EJRb@:]7j.K@\^"GDB# h5scp(\pWZroaa!!:v͚ :6Ql_qք0aSNb#ڵxF_{Ӕ̔!d-*vϒQ[7W}@dڕίVjxgϞ=K Q0lcnݺʕ뮻}/TȻDвe? RjZռyV۶۵ѵkZh޽3o}j~4kd$zOi@LLDl,G$QE a#\Reۚ @tkHC"(ǝ*YB[\ _}zxxO,` L "gr]̫WXbvAfg׆l%Z4ZnOdX ʘ=L/$(|o|…ygr*THS'um:xO=׵ vDw?kם!!v]7}|&zy%nԢE| MW/z*-[h%}ڷi="e=ЏѨgw\ D%sa }'7Y*q\T3 IjZzcҲ< 4hXllRVNj8qb޽"1iF*V(;+=@"EJڵ4ou=m:s}OwlPs/\ RHAAƂwtvieˬf͖6nYz&׭_jբ*W)SieU~C!6yW.ZU59. ysJ2!MHVaz ̗Uo]hRUѮ=3:=o~}) ^N8;jӹf]f/#.Jڵ!+ѴiLl,z /Pq ,R88}AmfS~? §1N?M U֯_^~0kuT ?VF蚉!+Y- NF+ch"E| xHժ՛۸ wVvxxDߚNw$${Ul6~إy|k+ߓfKflCҦM7h0F*UyeݺDE (Z#"wF{ c{2vRծ]n"fo UAS{>9Kytg%|;QkuQ r[@6*dK)Z3nF sO;,9Zua*yx*)Y/4v+_m-_}o7ײ%ZaNFhի-/M4ed:H!ql*+m4=x*Y$=GzYgXŋAPTZ2t VA\ gIJJ .MCJהоqb-kW0N m{*UTtF]KR35ZѬ z ;` /՟3 xmԬ=3 2;r']G7L_?f͈GmUlנ C#<Y?8/y{{c*FFY}9.G'_|Ȉꆊ5Qg^ȑ#WZ "D!O4}}U"˔)HR|GT^ `^j$&fa|بb=`(m}N]HjSMjI6y={ś͛GShJTJ;6Z{qiEzyy("8-˗/#""cئ)xذa>OUx[1W1 iѕޱKpCNǎi.7yBl>ذ`ʕWPZ$ͮ]a^v^ú|F-cb`l=|W^1|o߾,666֦.ӯU7&y@55XZRa z2 *I3=i/YQsl H@hٻvl$n4OWޅ4ꚯw.Y"ErOdǓJ*,Y| ԭ[w0( Zca&ZP.=UCq^0fh 8!Yߘ *Onn#kV6DQ25E!enҭc؞l[/k~7zϣ|Ku~qh.]U'BctU"fTʮT˖ ֱ+jo F!![Ӽu۶o4۸,0RuJ\d]벯띈+F=׷n];4lW_ǀUz[`[~UCK蹱; aT0BTyGöU#mU:[tv>^?rrMjDAwdzLb_ ^pJoۃ7zznٲD|j׾G9PH xK/aM+T5k֌QXܻwdU>9Pq!A+?~lek-۴AW^}}V5chY*Z¬ͭ^WH[~WؚQ!T DKg❫c{jm"r#jo{)c񁥖7qq7!,Se{m;~sED7I~EskנZsoҤɓdYpXO Z_=_|7Û-VD{z.e˝۴6]F+!~o6m*TCŊr~5_O?]n֘ AAAyZ.jk׮wd?~=9-@"wkjj^sayz PGzݺ ۟x`ȑMlGz,SO>s!/V3T.`[W9Ϭ +xdhxҸqW̸Ju#>kVMr]z(T!+ZuXJ}KPPjS^3+ Gz,lc\H^͛ Gm xs={|G*Vlٲ:gp5_|yxDD+UV+TRis,KQk7؊ ħ/rժUޥJ*]t*'+m 7x[<O?̓bp$VlJu1!ChHs1/"B F"z4*OlŪ<|;m6r[\n|moq -.6r[\n|moq -.XMv%tEXtcreate-date2010-07-21T11:05:59-04:00 ]%tEXtmodify-date2010-07-21T11:05:59-04:00TjtiIENDB`@@@ NormalCJ_HaJmHsHtHd@d @R Heading 1dd@&[$\$#5B*CJKH$OJQJ\aJph>>>`@"` @R Heading 2dd@&[$\$5B*CJOJQJ\aJphMJBDA@D Default Paragraph FontRiR  Table Normal4 l4a (k(No List4U4 @R Hyperlink >*ph3fB^B @R Normal (Web)dd[$\$(O( @Rcap1xf\f@R z-Top of Form$&dPa$<CJOJQJ^JaJl]l@Rz-Bottom of Form$$dNa$<CJOJQJ^JaJOA @Rfn :?@A]I 000000000000:?A]I K0(K0(K0(K0(@K0(K0(K0(K0(K0(K0(?    = XC 8@0(  B S  ?}0Ll}0Au}0 Dug o C*urn:schemas-microsoft-com:office:smarttagsmetricconverter9*urn:schemas-microsoft-com:office:smarttagsplaceB*urn:schemas-microsoft-com:office:smarttagscountry-region (19 grams ProductIDm~"'8rwp y { } ~ j s >> 33> p y  ZF%Jb}~{ <R &s" ~h Vna;<0-ک#&9llB&7*Lr M\BMO|brPuh|O`@$.0aA;fNb4f Y~{ZotAq,M/ ^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`.^`.pp^p`.@ @ ^@ `.^`.^`.^`.^`.PP^P`.^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`.^`.pp^p`.@ @ ^@ `.^`.^`.^`.^`.PP^P`.^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(hh^h`CJOJQJo(88^8`CJOJQJo(o^`CJOJQJo(  ^ `CJOJQJo(  ^ `CJOJQJo(xx^x`CJOJQJo(HH^H`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(~{llB M4f0-%JMObrPA;f{Zo ZtAq/&7*Lh|O`;#&9" R.0a 'QX%[hT8sSsSCjj3  S#15~z(CWv%; T <<B:4 ZvgX%[ , EhD}hjX%[ hhA(& xxV-)y-` #+vg9-KBhS#1X%[@h535~z:4jjw> 6D}hKBV-)xP~yE\{idI8Py-`8yQT hhRBd 8U9-WsSxX%[Ty-` hvQhKBh\{iy-` Zh/hsV-) xWuD}h(CWvQKyS#1 r*CzD}h2}dY} x D}Q@RO7k@2 P@UnknownGz Times New Roman5Symbol3& z Arial7Georgia7&  Verdana?5 z Courier New;Wingdings"1hsFsF  !4d 2HX)?@R2Caffeine Chemistry KOYTRAKIS.`                Oh+'0|  8 D P\dltCaffeine Chemistry KOYTRAKIS Normal.dot.2Microsoft Office Word@F#@N@N ՜.+,D՜.+,X hp  MICROSOFT OFFICE 2003 GREEK ' Caffeine Chemistry Title 8@ _PID_HLINKSAf6Dhttp://chemistry.about.com/bio/Anne-Marie-Helmenstine-Ph-D-7815.htm  !"#$%&'()*+,-./0123456789:;<=>?@ABCEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijkmnopqrsuvwxyz{~Root Entry F`+SData [f1TableDNWordDocument.SummaryInformation(lDocumentSummaryInformation8tCompObjq  FMicrosoft Office Word Document MSWordDocWord.Document.89q