ࡱ>   bjbjʱʱ 4__%%LL########8#$&4#5'G("i(i(i()%9?$|r=Q#B))BB=##i(i(4IIIB#i(#i($IBIIJ\pEo`F_Bߨ0G|#XBBIBBBBB==HBBBBBBBBBBBBBBBBL W": Professor Kathryn Maitland CURRICULUM VITAE 1 Personal Details Name: Kathryn Maitland Date of Birth: 8 November 1962 City of Birth Halewood, Liverpool Citizenship British (United Kingdom) Address KEMRI-Wellcome Trust Programme PO Box 230 Kilifi Kenya Telephone Mobile +254 733411022 UK Mobile: +44 7543721710 Email  HYPERLINK "mailto:Kathryn.maitland@gmail.com" Kathryn.maitland@gmail.com K.maitland@imperial.ac.uk Current Professional Appointments: Professor of Paediatric Tropical Infectious Diseases Since 2009 Imperial College, London Honorary Consultant in Paediatric Infectious Disease Since 2000 Department of Paediatrics Honorary Fellow Medical Research Council Clinical Trials Unit at UCL Since 2009 Current expert appointments Visiting professor University of Oxford, United Kingdom Since 2015 Visiting professor Busitema University, Mbale, Uganda Since 2015 Board member Institute of Global Health Innovation, Imperial College London Since 2014 2 Other Appointments and Affiliations Professional Bodies and Organisations Memberships: Royal Society of Paediatrics and Child Health Royal Society of Tropical Medicine and Hygiene. Committees: 2020 WHO Respiratory Working Group COVID-19 Clinical Management & Characterization 2020 MRC Global Health Faculty of Experts 2020 MRC GCRF: Nutrition review panel committee 2020 NIHR RIGHT (Research and Innovation for Global Health Transformation) 2011-2019 ISARIC Executive committee Member: African Chair 2011-2014 Imperial College: Executive Member of Global Health Group 2014-17 Associate member of the Institute of Global Health Innovation 2017- EDCTP Career Developmental Fellowship Reviewer and Co-Chair 2017-2020 Academy of Medical Sciences: Committee Member for selection of new fellows 2017-2021 Wellcome: Clinical Research Career Development Fellowship SchemeCommittee Member 2018 EDCTP Senior Research Fellowship Reviewer and committee member 3 Prizes Awards/Honours Academic Awards: 2016 Fellowship Academy Medical Sciences 2012 Imperial College: recognition for outstanding achievement and exceptional contribution 2012 FEAST Trial BMJ Paper of the Year Award 2011 2009 Promotion to Professor of Tropical Paediatric Infectious Diseases, Imperial College 2006 Wellcome Trust Value in People award, Imperial College, London 2006 HEFC Clinical Senior Lectureship Award 1999 Wellcome Trust- Imperial Lecturer in Tropical Clinical Medicine 1996 Federation of Infection Society: Prize for Best Research Project 1995 Wellcome Trust Fellowship in Clinical Tropical Medicine 4 Grants Current 2019 Co-applicant: MRC/DfID/Wellcome Trust Global Health Trials: "Hydroxyurea: Pragmatic Reduction in Mortality and Economic burden (H-PRIME) 4,375,000 2018 Principal Investigator: 209265/Z/17/Z: Severe Malaria Africa A consortium for Research and Trials (SMAART) consortium Wellcome Collaborative Award in Science Grant 3,944,185.00 2018 Principal Investigator: MR/R018502/1 Gastroenteritis: rehydration for children with severe acute malnutrition MRC Developmental Award (GASTRO-SAM) 162, 2018 Co-Investigator ALERRT: African CoaLition for Epidemic Research, Response and Training (sub contract 240,942.50 to Mbale Clinical Research Institute) 2017 Principal Investigator: MR/J012483/1 TRACT trial TRansfusion and TReatment of severe Anaemia in Africa Children: a randomised controlled Trial MRC extension 218,060 (April 2017-Oct 2019) 2017 Principal Investigator: 1636 COAST-Nutrition, EDCTP2 Call for Proposals RIA2016S - Strategic actions supporting large-scale clinical trials Euro 3,394, 200 (October 2017- Sept 2021) 2017 Co-Investigator: MR/P022251/1 Mechanisms underlying enhanced infection prophylaxis for advanced HIV in Africa PI Andy PrendergastQueen Mary, University of London MRC Research Grant 36months813,361 (June 2017 2017 Principal Investigator: MR/P021492/1 Pharmacokinetics of azithromycin in severe malaria bacterial co-infection in African children 24 months 168,000 (July 2017 June 2019) 2017 Co-Supervisor: TMA2016SF-1514 EDCTP Senior Fellowship Award to Peter Olupot-Olupot: Strengthening Malaria Epidemiological, Pathophysiological and Intervention Studies in Highly Endemic Eastern Uganda (MEPIE Study) Euro 468,551. 2017 Co-Investigator: An Innovative Passive Dietary Monitoring System - a dietary monitoring system for effective assessment of individual nutrient intake in Low or Middle Income Countries (LMICs) - funded by Bill and Melinda Gates Foundation (US$1.57M) (Investment ID: OPP1171395) 2017 Co- Investigator: MRC Confidence in Global Nutrition Award (MC_PC_MR/R019258/1) (PI Gary Frost) The Role of Nutrients, Gut Dysfunction and the Gut Microbiome in Determining Health Outcomes in Undernutrition 183, 444 2016 Co- investigator: MR/P06873/1 Single Tolerability and safety of single low dose primaquine in African children with acute uncomplicated falciparum malaria and glucose 6 phosphate dehydrogenase deficiency, Principal Investigator (PI) Nick Day; Wellcome Trust MRC DFid 1,818,500/= (2017-2019) 2016 Co-Investigator: 203077/Z/16/Z Wellcome Trust East African Major Overseas Programme 45,500,000 1st Oct 2016- 31st Aug 2021; 1,500,000 Allocated to Imperial College for Mbale Clinical Research Institute, Uganda 2013 Principal Investigator: MR/L004364/1 COAST trial Children Oxygen Administration Strategies Trial Wellcome Trust MRC DFid 2,750,000 Imperial College internally managed awards 2017- 2018 Principal Investigator: Development of a therapeutic feeding strategy to support gut integrity in malnourished children in East Africa Imperial (Phase II trial) Confidence in Concepts Joint Translational 188,000 2018-2019 Principal Investigator: Understanding the Gut Microbiome in African children: stakeholder meeting Research England Global Challenges Research (35,000) 2019 -2020 Principal Investigator: RETRACT: REalising Transfusion Trial in African Children with Severe anaemia knowledge sharing meeting: Research England Global Challenges Research Fund (85,000) Previous Grants 2013 Co-Chief Investigator: Understanding of pathophysiology of sepsis and the tissue effects of fluid resuscitation and transfusion NHMRC, Australia (AUS: 1,000,000) 2012 Principal Investigator: TRACT trial TRansfusion and TReatment of severe Anaemia in Africa Children: a randomised controlled Trial MRC 3,300,000 (MR/J012483) 2011 Co-applicant: REALITY trial Reduction of EArly HIV mortaLITY in adults and children (coapplicant/site PI) Global Health Trials (Welcome Trust MRC Dfid) 4, 600,000 2011 Co-Principal Investigator: Appropriate Fluid Resuscitation for Shock in Severely Malnourished Children AFRIM STUDY; Medicines Sans Frontieres/EpiCentre (180,000 2011 Principal Investigator: Fluid Management of severely-ill children in Africa. Alexander Fleming Dissemination Award, MRC, London (30,000) KMaitland Diana Gibb 2010 Co-Principal Investigator: Investigating gut mucosal integrity and gut metabolome in children with severe malnutrition: metabonomic profiling. Halley Stewart Trust (+co-funding Imperial College) K Maitland N Pathen, G Frost, Elaine Holmes 2010 Co-Principal Investigator: CAPMAL: Studies of myocardial function in children with severe malnutrition Else Kroener-Fresenius Stiftung (90,000 2007 Co-applicant: AQUAMAT trial: An open label randomised comparison of injectable artesunate and quinine in patients with severe falciparum malaria in Africa, PI Nick White, Wellcome Trust 2, 000,000 2007 Principal Investigator: Endotoxaemia in severe and complicated malnutrition (XOMA 12,000/Spectral diagnostics) 2007 Principal Investigator: FEAST trial A multi-centre randomised controlled trial of volume expansion in children with severe malaria (FEAST) MRC Clinical Trials Grant 2,700,000 5 Evidence of esteem, external visibility and profession activities Awards 2011 FEAST Trial won BMJ paper of the year award 2015 Director Imperial College Centre for African Research and Engagement (ICCARE) 2016 Fellow of the Academy of Medical Sciences Visiting Professor 2015 Visiting professor: MCMasters University and Toronto Childrens Hospital; Canada 2013 Visiting professor: Boston Childrens Hospital /Harvard Medical School Department of Continuing Education: The origins of the FEAST and beyond. 2011 Visiting professor: University of Pittsburgh (and Medical Center & Childrens Hospital) Annual Oration Awards 2020 John Hinds Lecture: Critical Care Reviews Meeting Belfast, N Ireland 2020 John Snow Oration: Annual Medal: Royal College of Anaesthetists: Manchester 2017 Annual Asmunds Laerdal Memorial Lecture: Malmo, Sweden 2017 Wallcott Oration: University of Queensland, Brisbane 2016 Annual Bennet Seminar: State of the Art Meeting in Critical Care, London Advisory/ Guideline committees 2020 NERVTAG COVID-19: supportive care trials subgroup 2019 Roundtable meeting on global clinical research capacity Chair Anne Johnson Academy Of Medical Sciences 2019 Global Task Force for Cholera Control (GTFCC) Case Management Working Group, New Dehli November 2019 2018 Expert Advisor: Global Task Force for Cholera Control (GTFCC) Case Management Working Group 11 12 December 2017, the Wellcome Trust, London, UK 2018 Expert Advisor World Health Organization: Sepsis Technical Expert Meeting Geneva, Switzerland, 16-17 January 2018 2014 7th World Congress on Pediatric Intensive and Critical Care May 4-7, 2014, Istanbul, Turkey. Member of the International Scientific Committee in the track The Milieu. 2014 Member of the Review panel of the Institute of Global Health Innovation, Imperial College London 2013 Technical Expert Advisor, Paediatric Emergency Triage Assessment and Treatment Guidelines and Training Materials Review and Scoping Meeting, WHO Geneva March 2013 Advisory Member, Technical Group for Management of Severe and Moderate Malnutrition, International Atomic Energy Agency Bangkok May12th 2013 Acute Dialysis Quality Initiative (ADQI) consensus conference Fluid management in critical illness (Technical Group: When and how to administer fluids for resuscitation). 2012 Consensus Round Table Symposium on Fluid resuscitation Brussels March 17-19 2012 Kenya Paediatric Association meeting: Management of Shock in African Children- evidence review and guidelines Nairobi October 2011-2012 Member of Technical Review Team; author and editor of review guidelines, Technical Expert Group on Management of Severe Malaria, World Health Organization 2006-2008 Global Sepsis Initiative World Federation of Paediatric Critical Care 2007-2009 Severe Malnutrition Technical Advisory committee WHO Geneva 1999 Health Protection Agency Advisory Committee: UK guidelines for the management of Severe malaria in children Guideline Review Committees Dilaforette: Sevuparin for severe malaria: Member of Medical Advisory Board, Jan 2014 WHO Geneva: Emergency Triage and Treatment: Management of Severe Illness in Resource-poor hospitals: Guideline review March 2013 ADQI XII consensus building conference designed around a modified Delphi, Sept 2013 Process: Four Phases of Fluid management: September 2013, London Consensus Round Table Symposium on Fluid resuscitation Brussels March 17-19 2012 Kenya Paediatric Association Meeting: Management of Shock in African Children- review of the evidence October 2012 Industrial connections 2019 Cipla: Donation of Azithromycin for TABS (Severe Malaria) Trial 2017 Heyek Medical Devices: Biphasic Cuirass Ventilation (BCV) devices for Cerebral malaria trial 2017 Medicines for Malaria Venture (Dr Pierre Hugo Director MMV) donation of antimalarial drugs for SMAART (severe malaria consortium) 2017 UNICEF: donation of Ready-to-Use Therapeutic Feed for COAST Nutrition 2014 Fisher and Paykel: Donation of AVRO system (High Flow Oxygen System) for POST and COAST trials 2013 Cipla: Donation of Cotrimoxazole for TRACT Trial (Dr Hamied (Chairman and MD)) 2008 Spectral Diagnostics and XOMA: Endotoxin studies 2008 Baxter, Plasma Division USA: Donation of Albumin and Saline to FEAST trial Contributions to Industry through Teaching/Training 2014 Dilaforette: Sevuparin for severe malaria: Member of Medical Advisory Board 2008 GSK Phase III vaccine trial review of clinical definitions, data collection and training materials fluid Teaching materials 2020 Research England: DVD and online dissemination material TRACT trial and stakeholder meeting February 2020, Kampala, Uganda 2013 DVD dissemination material: The Anatomy of a clinical Trial: FEAST 2013 Harvard Medical School Department of Continuing Education/Boston Childrens Hospital: Open Pediatrics: The FEAST trial (webcast) October 29th 2013 2013 The Anatomy of a Clinical Trial: FEAST 30-minute DVD on the how and why clinical trials are conducted. ( HYPERLINK "http://www.youtube.com/watch?v=GdMMuURsZQg" www.youtube.com/watch?v=GdMMuURsZQg 2006 Malaria: Diagnosis in Children and Treatment in Children Wellcome Trust (CD rom) Expert Advisor Wellcome Trust Publishing Group 2003 Gates e-learning course initiative: Severe Malaria Module, University of Oxford Editorial boards Malaria Journal BMC Medicine Trial Steering Committees and Data Monitoring Committee 2018 SQUEEZE Trial: a trial to determine whether septic shock reversal is quicker in pediatric patients randomized to an early goal directed fluid-sparing strategy vs. usual care (DSMB member) 2014 Parenteral artesunate compared to quinine as a cause of late post-treatment anaemia in African children with hyperparasitaemic P. falciparum malaria (DHART) DMC member 2013 Antimalarial Dose Justification and Tolerability Study of DHA-Piperaquine (Adjust) DMC member 5 Education/Qualifications Education: 1986 MBBS, St. Bartholomews Hospital, University of London, UK 1989 Diploma in Child Health, London, UK 1991 MRC Paediatrics, UK 1997 Diploma of Tropical Medicine and Hygiene, London, UK 2000 PhD, University of London, UK 2015 Fellow of the Royal College of Paediatrics 2016 Fellow Academy of Medical Sciences 6 Professional History 2009 to date Professor of Paediatric Tropical Infectious Diseases 2000 to date: Based fulltime at The Wellcome Trust Unit-KEMRI, Kilifi, Kenya 2006-2009 Senior Lecturer in Tropical Paediatric Infectious Diseases, Honorary Consultant Paediatric infectious diseases, St Marys Hospital 1999-2006 Clinical Lecturer in Tropical Paediatric Infectious Diseases, St Mary Hospital, London Honorary clinical assistant, Hospital for Tropical Diseases, London Honorary Specialist Registrar in Microbiology, John Radcliffe, Oxford 1998-1999 Specialist Registrar in Microbiology, John Radcliffe Hospital, Oxford 1998 Specialist Registrar in Paediatrics, John Radcliffe Hospital, Oxford 1995-1998 Wellcome Trust Research Fellow, Centre for Infectious Diseases and Institute of Molecular Medicine, John Radcliffe Hospital, Oxford Clinical Scientist, Epidemiological studies in Vanuatu, S West Pacific. Senior Registrar Paediatrics Edgware General Hospital, London Paediatric Registrar, Alder-Hey Regional rotation, Liverpool 1988-1989 SHO/CMO in Paediatrics, Queen Elizabeth Childrens Hospital, London Senior House Officer: Obstetrics, Whipps Cross Hospital, London 1986 - 1987 House Surgeon, Hackney-Homerton Hospital, London House Physician, Whipps Cross Hospital, London 7 Academic Supervision Current PhD Supervision Agklinta Kiosia, Exploring the effect of legume enriched feeds on gut health in undernourished children Jan 2020 Co-Supervisor Dr Eva Nabawanuka: Role of point of care tests and biomarkers in refining the diagnosis of severe pneumonia among children and optimizing benefit of oxygen and nutritional therapy June 2019 Main Supervisor Dr Damalie Nalwanga Assessment of the relationship between muscle and fat and survival in children suffering from pneumonia and role of nutritional supplementation June 2019 Main Supervisor Dr Clare Wilson: Does Factor H contribute to severity of Malaria in East Africa? November 2017- Co Supervisor Dr Fiona McQuaid: Investigation of host red blood cell receptors essential for rosetting in severe Plasmodium falciparum malaria Institute of Immunology and Infection Research University of Edinburgh Registration March 2015 Co-supervisor Dr Nchafatso Obonyo Myocardial physiology in septic shock and response to volume expansion treatment 2015 Co-supervisor Completed PhD Students Kevin Walsh: Impact of gut dysfunction in appetite regulation and susceptibility to infection in African children with severe anaemia (Imperial College, London 2020) 2020 Co-supervisor Elizabeth George The "acutely sick" African child: applying new statistical methods to delineate mortality risks and identify ways to improve management. (University College, London April 2019) Co-supervisor Dr Peter Olupot Olupot, Uganda Burden, spectrum, complications and aetiology of severe malaria in East Uganda (Open University, 2015) Main supervisor Dr Samuel Akech Prevalence, aetiology, and management of shock in children admitted to rural hospitals in East Africa (University of Oxford, 2011) Main supervisor Dr Oliver Hassall Feasibility of using umbilical cord blood as a source of blood for transfusion for young children with severe anaemia (Liverpool University 2009) Co-supervisor MSc/MRes supervision: Dr Eulalia Farre Malnutrition: (MCS, Oxford Brook University, Oxford 2001) Main supervisor Dr Simon Kotyar Yale Association of spleen size with clinical manifestations of severe malaria (MSC in Tropical Medicine LSTMH) 2010 Co-Supervisor Dr Adeel Iqbal Severe anaemia, haemoglobin threshold as evidence for transfusion Global Health MSC course Oxford (2011) Co-Supervisor Nicola Gowan: Investigation of evidence for gut barrier dysfunction and associated risk factors in children hospitalised with malnutrition in a sub-Saharan African population (2012) MRes External Supervisor Dr Nchafatso Obonyo: Management of Paediatric Shock: physiological considerations for children with septic shock or gastroenteritis Main Supervisor Dr Angela Aramburo Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa LSHTM Co-Supervisor MD supervision: Dr Bernadette Brent Cardiovascular physiology in children with acute severe malnutrition in Kenya Imperial College March 2015 Main supervisor 8 Other Collegiate Activities Peer Reviewer: Journals Archives of Disease in Childhood, Annuals of Tropical Medicine, British Medical Journal, BMC Medicine, BMC Paediatrics, Critical Care, Clinical Infectious Disease, Controlled Clinical Trials, European Journal of Neurology, European Journal of Nutrition, International Journal of Infectious Disease, Intensive Care Medicine, International Journal of Infectious Diseases, Journal of International Health, Journal of Infection, JAMA, The Lancet, Malaria Journal, New England Journal of Medicine, Transactions of the Royal Society of Tropical Medicine and Hygiene, Trends in Parasitology, Paediatric Infectious Disease Journal, PloS Journals (One and Medicine) Peer review: Grant Proposals Have reviewed grants for: NIHR, Wellcome Trust, Global Health Research Awards, Medical Research Council, Meningitis Research Foundation; EDCTP, Thrasher Foundation Panel Member Reviewer and Member of Expert Panel for MRC GCRF Foundation awards, London Nov 21st 2016 Reviewer and co-Chair EDCTP Mid-Career Fellowship Awards. EDCTP, The Hague 9th-11th May 2017 Review and panel Member Fellowships for Academy Medical Sciences, London March 2017 Judge on SPRINT data analysis Challenge Round New England Journal of Medicine, March 2017 PhD examination 2016 Katherine Plewes "Intravascular haemolysis, oxidative stress and acute kidney injury in severe falciparum malaria" University of Oxford, UK 2015 Lars Holst Benefits and harms of red blood cell transfusions in patients with septic shock in the Intensive Care Unit Rigshospitalet, Blegdamsvej 9,DK- 2100 Copenhagen , Denmark 2013 Josh Hanson Evaluation of Volume Status, Haemodynamics and Microcirculatory Flow in Adult Patients with Severe Falciparum Malaria Charles Darwin University, Darwin, NT Australia. 9 Guest/Plenary lectures to learned Societies- last 8 years 2020 Plenary and multiple lectures: Scottish Intensive Care Society Annual Meeting, St Andrews Jan Oration and multiple lectures: Critical Care Reviews, Belfast Jan 2019 Challenges in Clinical Trials in Critical Ill Hospital: Colloquium Rigshospitalet, Copenhagen ANZICS CTG 21st Annual Meeting on Clinical Trials in Intensive Care, Noosa, Queensland, Australia Guest Speaker: Tract Trial Results 6th SG-ANZICS Asia Pacific Intensive Care Forum 2019, Singapor Plenary: My Life in Global Health Transfusion threshold for children in Africa: The TRACT trial GASTRO Trial: Gastroenteritis: aggressive versus slow intravenous rehydration trial ASID Annual Scientific Meeting 2019 Darwin Plenary: Challenges in Critical Illness Severe Malaria in African Children: the need for a consortium Gordon Research Conference on Malaria Les Diablerets, Switzerland TRACT trial results International Blood Transfusion conference, Basal, Switzerland TRACT trial results 2018 North East Intensive Care Society Spring Meeting 16th March 2018 Reflections on air & water What we know, and what we think we know how unexpected results can help clinical practice. Boston World Trade Centre: New England Journal of Medicine/ Massachusetts Medical Society Can we control the Next Epidemic before it becomes a pandemic? Keynote Speaker: Acquiring knowledge while saving lives. 27th April 2018 MEDREACH conference, Glasgow Sepsis in Children does evidence from LMICs apply in the UK (13.10) Sepsis Managements and Controversies Wellcome Trust/Academy of Medical Science : Exploring Good Clinical Practice Guidelines 2017 37th International Symposium on Intensive Care and Emergency Medicine, Brussels, March 21st- 24th March Invited Speaker Transfusion in children - Transfusions Managing the sick child in Africa International perspectives Different targets in children - How much oxygen Aligning Incentives for Sharing Clinical Trial Data summit, Boston, USA April 3rd-4th Invited participant and Judge of SPRINT challenge Swedish Annual Paediatric meeting Gothenburg, April 23rd-25th Plenary: FEAST trial and panel discussion. Academy Medical Sciences, London: Strengthening Research in LMICs co-chair of meeting 3rd-4th July Critical Care Meetings, Brisbane 24th-25th July Emergency Medicine FoundationSymposium Research without Boarders: plenary to Critical Care group 34th Congress of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine Malmo Sept Annual Asmunds Laerdal Memorial Lecture: Deconstructing fluid resuscitation in African Children A forensic analysis of the FEAST trial Sepsis management in resource limited Africa: challenges and opportunities Critical Care Society of South Africa Annual Congress. Sun City October 19-22th Plenary: What happens after bolus therapy in children with septic shock: The Bigger Picture Transfusion: issues in Africa Is the severely malnourished heart at risk? Important considerations Global Health Day 2017: The UK Contribution to Innovation in Global Health Francis Crick Institute, London 4 December Emergency and critical care in Africa: where there is no intensive care unit 2016 BioMalPar Heidelberg, Germany 18th -20th May SMAART: Severe Malaria in African children: A Research and Trials consortium SMACC Dublin; Ireland 15-17th June COAST trial: Childrens Oxygenation Strategies Trial Which Children in Africa should be transfused: TRACT trial Panel Discussion: Publishing and the future of Critical Care Knowledge Jeff Drazen(NEJM editor) Richard Smith (ex BMJ editor) Kathy Rowan, John Myburgh, Rob Mac Sweeney Sara Bassin, Kath Maitland Chair: Simon Finfer 21st International HIV conference Durban 18th-22nd July 2016 34th International Congress of the ISBT, Dubai, Sept 2016 Plenary: Transfusion and Treatment of severe anaemia in African children: a randomised trial Oxford Tropical Network Meeting Sept 2016 : Plenary: Severe Malaria World Sepsis Conference Sept 2016: Sepsis in Africa MSF international Paediatric Day Sept 23rd Chancery Lane London : invited speaker ICS State of the ART 2016 meeting, 5-7th December 2016, ExCeL London. Invited Speaker Annual Bennet Seminar: Tropical Tales from the Front Line Challenges for Oxygen Therapy The paediatric COAST trial Africa: challenges and opportunities: Sepsis in resource poor settings 2015 UCT-Imperial Global Health Fellows, Summer School, Cape Town, SA January 29th-30th Panel - Global Health: Themes, trends and opportunities My life in Global Health Oxford Tropical Network Conference 2015, Siem Reap, Cambodia March 9th-11th Plenary: Management of Severe Malaria in African Children ISN World Nephrology Conference Cape Town March 13th -17th Fluid management in acute sepsis : The kidney in children with critical illness in the developing world Fluid and Electrolytes management: paediatrics CPD event SMACC Chicago 2015; USA 23-26th June Fluids and Kids: What Now? Cage Match: All Non-Cardiac PICU's Should Close (Pro Con debate) Q&A: Paediatrics Controversies Malaria : BEAT THE BUGS Canadian Critical Care Conference Toronto, 26th-28th October Fluids: what now? Severe malaria: management in resource limited setting Issues for transfusion in Africa 2014 Invited Speaker: FEAST trial and management of shock: Ho Chi Minn, Vietnam Intensive Care meeting Invited Speaker 7th World Congress on Pediatric Intensive and Critical Care May 4-7, 2014, Istanbul Fluid boluses-evidence from research ICU without ventilators ASTMH 3-6th November New Orleans Plenary: FEAST Trial Renal injury in malaria symposium: Malaria and its consequences Myocardial function in severe malnutrition 14th Annual Education day in Paediatric Anaesthesia St Bartholomews Hospital 18th November Invited Speaker FEAST and beyond: insights into mechanisms for poor outcome 2013 Evidence Live: High Quality Trials in African Children Oxford March 2013 Hosted by Centre for Evidence-Based Medicine, The BMJ Severe acute and moderate malnutrition in South-East Asia (jointly with the International Malnutrition Task Force; IMTF) Technical Meeting; Guest Lecture. Plenary: The FEAST trial Association of Anaesthetists of Great Britain & Ireland, Dublin Sept 2013 Invited Speaker: High quality African trials in emergency care: inform evidence-based, rather than eminence-based, management practice International Primary Care Research Leadership Programme, Worcester College, Oxford 2012 Keynote Debate: EMSSA 2013 Conference, Cape Town, South Africa:  Do fluids kill children 2012 Winter Symposium Perioperative Care and Outcome : role of the anesthetist, intensivist and( emergency physician. Leuven, Belgium February 2012 International Symposium of Intensive Care and Emergency Medicine (ESICM) Brussels March 2012 MSF expert meeting of fluid management of Pediatric Shock Brussels, 5th March 2012 Keynote: Annual Conference Royal College of Paediatrics and Child Health Glasgow 22-24 May 2012 Guest Lecture East African DTMH Moshi 14th Sept 2012: Management of shock and The FEAST trial International Keynote Speaker Australian and New Zealand Intensive Care Societies (ANZICS) Adelaide October 25th-27th 2012 Consent in Vulnerable populations FEAST trial Managing Sepsis in Resource Poor Settings More than just wet: why fluids may harm Guest Speaker: FEAST trial Paediatric Anaesthesia Meeting, St Barts Hospital London Nov 2012 Plenary: FEAST trial TRANSFUSION meeting; Royal College of Pathologists Nov 2012 2011 Invited Speaker: FEAST trial _ ANZICS annual Meeting; Noosa March 2011 International Meeting of the World Federation of Pediatric Intensive and Critical Care Societies Sydney March 2011 Intravenous Fluids where are we? (Plenary) Sepsis in children in Africa (Plenary) Severe malnutrition: therapeutic Challenges (Plenary) Invited Speaker: Transfusion priorities for African Children: British Society of Haematology Annual Meeting Brighton, April 4-6th 2011. Invited Speaker: Public Engagement and Clinical Trials: New Models and Disruptive Technologies Mount Sinai School Of Medicine, New York, June 2728th, 2011 Invited Speaker: Evidence Based Perioperative Medicine World Congress The Great Fluid Debate The Institute of Education, London July 5th 2011 How do we treat severe malaria? Hot Topics In Infectious Disease, Oxford July 14th 2011 Plenary: Management of children with severe malnutrition CAPGAN London, July 21st 2011 Kenya National Malaria Forum, Nairobi Kenya October 2011 European Society of Intensive Care Medicine (ESICM) Annual Congress Berlin Oct 2011 FEAST trial Management of Sepsis in Critical Sick Children in Africa Invited Guest Speaker FEAST Trial: Annual Meeting of the Dutch Paediatric Society, Veldhoven, The Netherland Nov 2011 Management of Infection in Intensive Care, London 2nd November 2011 10 All Publications Book Chapters Blood transfusion in resource-limited settings O. Hassel, I Bates and K Maitland; Hunters Tropical Medicine 9th Edition Magill Maguire Ryan Solomon; 2011 Life-threatening tropical infections K Maitland, B Wills Infectious Diseases in the Pediatric Intensive Care Unit Edited by Simon Nadel & Brett Giroir, Springer London Malaria Kathryn Maitland, Charles Newton, Rakel and Bope Conns Current Therapy, 2002 W. B Saunders Papers Published ADDIN EN.CITE  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_1" \o "Walker, 2020 #695" 1-189]  ADDIN EN.REFLIST 1. Walker SM, Cox E, Revill P, Musiime V, Bwakura-Dangarembizi M, Mallewa J, Cheruiyot P, Maitland K, Ford N, Gibb DM et al: The cost-effectiveness of prophylaxis strategies for individuals with advanced HIV starting treatment in Africa. Journal of the International AIDS Society 2020, 23(3):e25469. 2. Uyoga S, Wanjiku P, Rop JC, Makale J, Macharia AW, Nyutu GM, Shebe M, Awuondo KA, Mturi N, Woodrow CJ et al: Plasma Plasmodium falciparum Histidine-Rich Protein-2 concentrations in children with malaria infections of differing severity in Kilifi, Kenya. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2020. 3. Olupot-Olupot P, Wabwire H, Ndila C, Adong R, Ochen L, Amorut D, Abongo G, Okalebo CB, Akello SR, Oketcho JB et al: Characterising demographics, knowledge, practices and clinical care among patients attending sickle cell disease clinics in Eastern Uganda. Wellcome Open Res 2020, 5:87. 4. Jobarteh ML, McCrory MA, Lo B, Sun M, Sazonov E, Anderson AK, Jia W, Maitland K, Qiu J, Steiner-Asiedu M et al: Development and Validation of an Objective, Passive Dietary Assessment Method for Estimating Food and Nutrient Intake in Households in Low- and Middle-Income Countries: A Study Protocol. Curr Dev Nutr 2020, 4(2):nzaa020. 5. Alhazzani W, Moller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A et al: Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Med 2020. 6. Alhazzani W, Moller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A et al: Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19). Critical care medicine 2020. 7. Uyoga S, Mpoya A, Olupot-Olupot P, Kiguli S, Opoka RO, Engoru C, Mallewa M, Kennedy N, M'Baya B, Kyeyune D et al: Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub-Saharan Africa. Vox sanguinis 2019, 114(4):340-348. 8. Uyoga S, Maitland K: Use of whole blood as the routine transfusion product in Africa. ISBT Science Series 2019. 9. Uyoga S, Macharia AW, Ndila CM, Nyutu G, Shebe M, Awuondo KO, Mturi N, Peshu N, Tsofa B, Scott JAG et al: The indirect health effects of malaria estimated from health advantages of the sickle cell trait. Nat Commun 2019, 10(1):856. 10. Uyoga S, Macharia AW, Mochamah G, Ndila CM, Nyutu G, Makale J, Tendwa M, Nyatichi E, Ojal J, Otiende M et al: The epidemiology of sickle cell disease in children recruited in infancy in Kilifi, Kenya: a prospective cohort study. Lancet Glob Health 2019, 7(10):e1458-e1466. 11. Talbert A, Ngari M, Bauni E, Mwangome M, Mturi N, Otiende M, Maitland K, Walson J, Berkley JA: Mortality after inpatient treatment for diarrhea in children: a cohort study. BMC Med 2019, 17(1):20. 12. Silaba M, Ooko M, Bottomley C, Sande J, Benamore R, Park K, Ignas J, Maitland K, Mturi N, Makumi A et al: Effect of 10-valent pneumococcal conjugate vaccine on the incidence of radiologically-confirmed pneumonia and clinically-defined pneumonia in Kenyan children: an interrupted time-series analysis. Lancet Glob Health 2019, 7(3):e337-e346. 13. Passmore MR, Obonyo NG, Byrne L, Boon AC, Diab SD, Dunster KR, Fung YL, Spanevello MM, Fauzi MH, Pedersen SE et al: Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock. Thromb Res 2019, 176:39-45. 14. Obonyo NG, Byrne L, Tung JP, Simonova G, Diab SD, Dunster KR, Passmore MR, Boon AC, See Hoe L, Engkilde-Pedersen S et al: Pre-clinical study protocol: Blood transfusion in endotoxaemic shock. MethodsX 2019, 6:1124-1132. 15. Njuguna P, Maitland K, Nyaguara A, Mwanga D, Mogeni P, Mturi N, Mohammed S, Mwambingu G, Ngetsa C, Awuondo K et al: Observational study: 27 years of severe malaria surveillance in Kilifi, Kenya. BMC Med 2019, 17(1):124. 16. Maitland K, Olupot-Olupot P, Kiguli S, Chagaluka G, Alaroker F, Opoka RO, Mpoya A, Walsh K, Engoru C, Nteziyaremye J et al: Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial. 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Brent B, Obonyo N, Akech S, Shebbe M, Mpoya A, Mturi N, Berkley JA, Tulloh RMR, Maitland K: Assessment of Myocardial Function in Kenyan Children With Severe, Acute Malnutrition: The Cardiac Physiology in Malnutrition (CAPMAL) Study. JAMA Netw Open 2019, 2(3):e191054. 26. Walsh K, Calder N, Olupot-Olupot P, Ssenyondo T, Okiror W, Okalebo CB, Muhindo R, Mpoya A, Holmes E, Marchesi J et al: Modifying Intestinal Integrity and Micro Biome in Severe Malnutrition with Legume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trial. Wellcome Open Res 2018, 3:95. 27. Taylor WR, Naw HK, Maitland K, Williams TN, Kapulu M, D'Alessandro U, Berkley JA, Bejon P, Okebe J, Achan J et al: Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa. BMC Med 2018, 16(1):11. 28. Siika A, McCabe L, Bwakura-Dangarembizi M, Kityo C, Mallewa J, Berkley J, Maitland K, Griffiths A, Baleeta K, Mudzingwa S et al: Late Presentation With HIV in Africa: Phenotypes, Risk, and Risk Stratification in the REALITY Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018, 66(suppl_2):S140-S146. 29. Post FA, Szubert AJ, Prendergast AJ, Johnston V, Lyall H, Fitzgerald F, Musiime V, Musoro G, Chepkorir P, Agutu C et al: Causes and Timing of Mortality and Morbidity Among Late Presenters Starting Antiretroviral Therapy in the REALITY Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018, 66(suppl_2):S132-S139. 30. Opi DH, Swann O, Macharia A, Uyoga S, Band G, Ndila CM, Harrison EM, Thera MA, Kone AK, Diallo DA et al: Two complement receptor one alleles have opposing associations with cerebral malaria and interact with alpha(+)thalassaemia. Elife 2018, 7. 31. Ominde M, Sande J, Ooko M, Bottomley C, Benamore R, Park K, Ignas J, Maitland K, Bwanaali T, Gleeson F et al: Reliability and validity of the World Health Organization reading standards for paediatric chest radiographs used in the field in an impact study of Pneumococcal Conjugate Vaccine in Kilifi, Kenya. PloS one 2018, 13(7):e0200715. 32. Olupot-Olupot P, Prevatt N, Engoru C, Nteziyaremye J, Amorut D, Chebet M, Senyondo T, Ongodia P, Ndila CM, Williams TN et al: Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalised children in Eastern Uganda. Wellcome Open Res 2018, 3:130. 33. Ndila CM, Uyoga S, Macharia AW, Nyutu G, Peshu N, Ojal J, Shebe M, Awuondo KO, Mturi N, Tsofa B et al: Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study. Lancet Haematol 2018, 5(8):e333-e345. 34. Mallewa J, Szubert AJ, Mugyenyi P, Chidziva E, Thomason MJ, Chepkorir P, Abongomera G, Baleeta K, Etyang A, Warambwa C et al: Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial. Lancet HIV 2018, 5(5):e231-e240. 35. Maitland K, Kiguli S, Opoka RO, Olupot-Olupot P, Engoru C, Njuguna P, Bandika V, Mpoya A, Bush A, Williams TN et al: Childrens Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia. Wellcome Open Research 2018, 2:100. 36. Macharia AW, Mochamah G, Uyoga S, Ndila CM, Nyutu G, Makale J, Tendwa M, Nyatichi E, Ojal J, Shebe M et al: The clinical epidemiology of sickle cell anemia In Africa. Am J Hematol 2018, 93(3):363-370. 37. Lipson M, Skoglund P, Spriggs M, Valentin F, Bedford S, Shing R, Buckley H, Phillip I, Ward GK, Mallick S et al: Population Turnover in Remote Oceania Shortly after Initial Settlement. Curr Biol 2018, 28(7):1157-1165 e1157. 38. Kotlyar S, Olupot-Olupot P, Nteziyaremye J, Akech SO, Uyoga S, Muhindo R, Moore CL, Maitland K: Assessment of Myocardial Function and Injury by Echocardiography and Cardiac Biomarkers in African Children With Severe Plasmodium falciparum Malaria. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2018, 19(3):179-185. 39. Kityo C, Szubert AJ, Siika A, Heyderman R, Bwakura-Dangarembizi M, Lugemwa A, Mwaringa S, Griffiths A, Nkanya I, Kabahenda S et al: Raltegravir-intensified initial antiretroviral therapy in advanced HIV disease in Africa: A randomised controlled trial. PLoS medicine 2018, 15(12):e1002706. 40. Iro MA, Sell T, Brown N, Maitland K: Rapid intravenous rehydration of children with acute gastroenteritis and dehydration: a systematic review and meta-analysis. BMC pediatrics 2018, 18(1):44. 41. Houston KA, George EC, Maitland K: Implications for paediatric shock management in resource-limited settings: a perspective from the FEAST trial. Crit Care 2018, 22(1):119. 42. Byrne L, Obonyo NG, Diab SD, Dunster KR, Passmore MR, Boon AC, See Hoe L, Pedersen S, Hashairi Fauzi M, Pretti Pimenta L et al: Unintended Consequences; Fluid Resuscitation Worsens Shock in an Ovine Model of Endotoxemia. American journal of respiratory and critical care medicine 2018. 43. Byrne L, Obonyo NG, Diab S, Dunster K, Passmore M, Boon AC, Hoe LS, Hay K, Van Haren F, Tung JP et al: An Ovine Model of Hyperdynamic Endotoxemia and Vital Organ Metabolism. Shock 2018, 49(1):99-107. 44. Aramburo A, Todd J, George EC, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G et al: Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa. BMC Med 2018, 16(1):37. 45. Olupot-Olupot P, Engoru C, Uyoga S, Muhindo R, Macharia A, Kiguli S, Opoka RO, Akech S, Ndila C, Nyeko R et al: High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017, 64(7):939-946. 46. Obonyo N, Brent B, Olupot-Olupot P, Boele van Hensbroek M, Kuipers I, Wong S, Shiino K, Chan J, Fraser J, van Woensel JBM et al: Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study). Crit Care 2017, 21(1):103. 47. Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC et al: Gender Parity in Critical Care Medicine. American journal of respiratory and critical care medicine 2017, 196(4):425-429. 48. Maitland K, Kiguli S, Opoka RO, Olupot-Olupot P, Engoru C, Njuguna P, Bandika V, Mpoya A, Bush A, Williams TN et al: Children's Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia. Wellcome Open Res 2017, 2:100. 49. Houston KA, Gibb JG, Mpoya A, Obonyo N, Olupot-Olupot P, Nakuya M, Evans JA, George EC, Gibb DM, Maitland K: Gastroenteritis Aggressive Versus Slow Treatment For Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO plan C versus slower rehydration. Wellcome Open Res 2017, 2(62):62. 50. Houston KA, Gibb JG, Maitland K: Oral rehydration of malnourished children with diarrhoea and dehydration: A systematic review. Wellcome Open Res 2017, 2:66. 51. Houston KA, Gibb JG, Maitland K: Intravenous rehydration of malnourished children with acute gastroenteritis and severe dehydration: A systematic review. Wellcome Open Res 2017, 2(65):65. 52. Hakim J, Musiime V, Szubert AJ, Mallewa J, Siika A, Agutu C, Walker S, Pett SL, Bwakura-Dangarembizi M, Lugemwa A et al: Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa. The New England journal of medicine 2017, 377(3):233-245. 53. Obonyo NG, Fanning JP, Ng AS, Pimenta LP, Shekar K, Platts DG, Maitland K, Fraser JF: Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review. Intensive Care Med Exp 2016, 4(1):38. 54. Nightingale H, Walsh KJ, Olupot-Olupot P, Engoru C, Ssenyondo T, Nteziyaremye J, Amorut D, Nakuya M, Arimi M, Frost G et al: Validation of triple pass 24-hour dietary recall in Ugandan children by simultaneous weighed food assessment. BMC Nutr 2016, 2. 55. Nabwera HM, Fegan G, Shavadia J, Denje D, Mandaliya K, Bates I, Maitland K, Hassall OW: Pediatric blood transfusion practices at a regional referral hospital in Kenya. Transfusion 2016. 56. Maitland K: Severe Malaria in African Children - The Need for Continuing Investment. The New England journal of medicine 2016, 375(25):2416-2417. 57. Church JA, Nyamako L, Olupot-Olupot P, Maitland K, Urban BC: Increased adhesion of Plasmodium falciparum infected erythrocytes to ICAM-1 in children with acute intestinal injury. Malaria journal 2016, 15(1):54. 58. Mpoya A, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Mallewa M, Chimalizeni Y, Kennedy N, Kyeyune D, Wabwire B et al: Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial. Trials 2015, 16(1):593. 59. Maitland K: Management of severe paediatric malaria in resource-limited settings. BMC Med 2015, 13(1):42. 60. Kiguli S, Maitland K, George EC, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Reyburn H et al: Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness. BMC Med 2015, 13(1):21. 61. Hassall OW, Thitiri J, Fegan G, Hamid F, Mwarumba S, Denje D, Wambua K, Mandaliya K, Maitland K, Bates I: Safety and efficacy of allogeneic umbilical cord red blood cell transfusion for children with severe anaemia in a Kenyan hospital: an open-label single-arm trial. The Lancet Haematology 2015, 2(3):e101-e107. 62. George EC, Walker AS, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Reyburn H et al: Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score. BMC Med 2015, 13(1):174. 63. Brent B: Cardiovascular physiology in children with acute severe malnutrition in Kenya London: Imperial College; 2015. 64. Olupot-Olupot P, Engoru C, Thompson J, Nteziyaremye J, Chebet M, Ssenyondo T, Dambisya CM, Okuuny V, Wokulira R, Amorut D et al: Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia. BMC Med 2014, 12(1):67. 65. Obonyo N, Maitland K: Fluid management of shock in severe malnutrition: what is the evidence for current guidelines and what lessons have been learned from clinical studies and trials in other pediatric populations? Food and nutrition bulletin 2014, 35(2 Suppl):S71-78. 66. Maitland K: New diagnostics for common childhood infections. The New England journal of medicine 2014, 370(9):875-877. 67. Madan J, Ades AE, Price M, Maitland K, Jemutai J, Revill P, Welton NJ: Strategies for efficient computation of the expected value of partial perfect information. Medical decision making : an international journal of the Society for Medical Decision Making 2014, 34(3):327-342. 68. Kotlyar S, Nteziyaremye J, Olupot-Olupot P, Akech SO, Moore CL, Maitland K: Spleen volume and clinical disease manifestations of severe Plasmodium falciparum malaria in African children. Transactions of the Royal Society of Tropical Medicine and Hygiene 2014, 108(5):283-289. 69. Kiguli S, Akech SO, Mtove G, Opoka RO, Engoru C, Olupot-Olupot P, Nyeko R, Evans J, Crawley J, Prevatt N et al: Authors' reply to Southall. BMJ 2014, 348:g1619. 70. Kiguli S, Akech SO, Mtove G, Opoka RO, Engoru C, Olupot-Olupot P, Nyeko R, Evans J, Crawley J, Prevatt N et al: WHO guidelines on fluid resuscitation in children: missing the FEAST data. BMJ 2014, 348:f7003. 71. Hoste EA, Maitland K, Brudney CS, Mehta R, Vincent JL, Yates D, Kellum JA, Mythen MG, Shaw AD, Group AXI: Four phases of intravenous fluid therapy: a conceptual model. British journal of anaesthesia 2014, 113(5):740-747. 72. Church J, Maitland K: Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review. BMC Med 2014, 12:31. 73. Anderson ST, Kaforou M, Brent AJ, Wright VJ, Banwell CM, Chagaluka G, Crampin AC, Dockrell HM, French N, Hamilton MS et al: Diagnosis of childhood tuberculosis and host RNA expression in Africa. The New England journal of medicine 2014, 370(18):1712-1723. 74. Severe malaria. Tropical medicine & international health : TM & IH 2014, 19 Suppl 1:7-131. 75. Todd J, Heyderman RS, Musoke P, Peto T: When enough is enough: how the decision was made to stop the FEAST trial: data and safety monitoring in an African trial of Fluid Expansion As Supportive Therapy (FEAST) for critically ill children. Trials 2013, 14:85. 76. Olupot-Olupot P, Urban BC, Jemutai J, Nteziyaremye J, Fanjo HM, Karanja H, Karisa J, Ongodia P, Bwonyo P, Gitau EN et al: Endotoxaemia is common in children with Plasmodium falciparum malaria. BMC infectious diseases 2013, 13:117. 77. Olupot-Olupot P, Maitland K: Management of severe malaria: results from recent trials. Advances in experimental medicine and biology 2013, 764:241-250. 78. Molyneux S, Njue M, Boga M, Akello L, Olupot-Olupot P, Engoru C, Kiguli S, Maitland K: 'The words will pass with the blowing wind': staff and parent views of the deferred consent process, with prior assent, used in an emergency fluids trial in two African hospitals. PloS one 2013, 8(2):e54894. 79. Maitland K, George EC, Evans JA, Kiguli S, Olupot-Olupot P, Akech SO, Opoka RO, Engoru C, Nyeko R, Mtove G et al: Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. BMC Med 2013, 11:68. 80. Kozich JJ, Westcott SL, Baxter NT, Highlander SK, Schloss PD: Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform. Appl Environ Microbiol 2013, 79(17):5112-5120. 81. von Seidlein L, Olaosebikan R, Hendriksen IC, Lee SJ, Adedoyin OT, Agbenyega T, Nguah SB, Bojang K, Deen JL, Evans J et al: Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012, 54(8):1080-1090. 82. Talbert A, Thuo N, Karisa J, Chesaro C, Ohuma E, Ignas J, Berkley JA, Toromo C, Atkinson S, Maitland K: Diarrhoea complicating severe acute malnutrition in Kenyan children: a prospective descriptive study of risk factors and outcome. PloS one 2012, 7(6):e38321. 83. Ramutton T, Hendriksen IC, Mwanga-Amumpaire J, Mtove G, Olaosebikan R, Tshefu AK, Onyamboko MA, Karema C, Maitland K, Gomes E et al: Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria. Malaria journal 2012, 11:276. 84. Maitland K, Babiker A, Kiguli S, Molyneux E: The FEAST trial of fluid bolus in African children with severe infection. Lancet 2012, 379(9816):613; author reply 613-614. 85. Hendriksen IC, Mwanga-Amumpaire J, von Seidlein L, Mtove G, White LJ, Olaosebikan R, Lee SJ, Tshefu AK, Woodrow C, Amos B et al: Diagnosing severe falciparum malaria in parasitaemic African children: a prospective evaluation of plasma PfHRP2 measurement. PLoS medicine 2012, 9(8):e1001297. 86. Hassall OW, Thitiri J, Fegan G, Pole L, Mwarumba S, Denje D, Wambua K, Lowe B, Parry CM, Mandaliya K et al: The microbiologic safety of umbilical cord blood transfusion for children with severe anemia in Mombasa, Kenya. Transfusion 2012, 52(7):1542-1551. 87. Brent B, Obonyo N, Maitland K: Tailoring management of severe and complicated malnutrition: more research is required first. Pathogens and global health 2012, 106(4):197-199. 88. Ala F, Allain JP, Bates I, Boukef K, Boulton F, Brandful J, Dax EM, El Ekiaby M, Farrugia A, Gorlin J et al: External financial aid to blood transfusion services in sub-Saharan Africa: a need for reflection. PLoS medicine 2012, 9(9):e1001309. 89. Akech S: Prevalence, aetiology, and management of shock in children admitted to rural hospitals in East Africa. Oxford: University of Oxford; 2012. 90. Thuo N, Ungphakorn W, Karisa J, Muchohi S, Muturi A, Kokwaro G, Thomson AH, Maitland K: Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study with Monte Carlo simulation. The Journal of antimicrobial chemotherapy 2011, 66(10):2336-2345. 91. Muchohi SN, Thuo N, Karisa J, Muturi A, Kokwaro GO, Maitland K: Determination of ciprofloxacin in human plasma using high-performance liquid chromatography coupled with fluorescence detection: application to a population pharmacokinetics study in children with severe malnutrition. Journal of chromatography B, Analytical technologies in the biomedical and life sciences 2011, 879(2):146-152. 92. Moisi JC, Gatakaa H, Berkley JA, Maitland K, Mturi N, Newton CR, Njuguna P, Nokes J, Ojal J, Bauni E et al: Excess child mortality after discharge from hospital in Kilifi, Kenya: a retrospective cohort analysis. Bulletin of the World Health Organization 2011, 89(10):725-732, 732A. 93. Mogeni P, Twahir H, Bandika V, Mwalekwa L, Thitiri J, Ngari M, Toromo C, Maitland K, Berkley JA: Diagnostic performance of visible severe wasting for identifying severe acute malnutrition in children admitted to hospital in Kenya. Bulletin of the World Health Organization 2011, 89(12):900-906. 94. Maitland K, Molyneux S, Boga M, Kiguli S, Lang T: Use of deferred consent for severely ill children in a multi-centre phase III trial. Trials 2011, 12:90. 95. Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T et al: Mortality after fluid bolus in African children with severe infection. The New England journal of medicine 2011, 364(26):2483-2495. 96. Maitland K, Akech SO, Russell EC: Mortality after Fluid Bolus in African Children with Sepsis: Reply. The New England journal of medicine 2011, 365(14):1348-1353. 97. Maitland K: Imaging in severe malaria. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2011, 12(2):237-238. 98. Lubell Y, Staedke SG, Greenwood BM, Kamya MR, Molyneux M, Newton PN, Reyburn H, Snow RW, D'Alessandro U, English M et al: Likely health outcomes for untreated acute febrile illness in the tropics in decision and economic models; a Delphi survey. PloS one 2011, 6(2):e17439. 99. Abubakar A, Holding P, Mwangome M, Maitland K: Maternal perceptions of factors contributing to severe under-nutrition among children in a rural African setting. Rural and remote health 2011, 11:1423. 100. Yacoub S, Lang HJ, Shebbe M, Timbwa M, Ohuma E, Tulloh R, Maitland K: Cardiac function and hemodynamics in Kenyan children with severe malaria. Critical care medicine 2010, 38(3):940-945. 101. Thuo N, Ohuma E, Karisa J, Talbert A, Berkley JA, Maitland K: The prognostic value of dipstick urinalysis in children admitted to hospital with severe malnutrition. Archives of disease in childhood 2010, 95(6):422-426. 102. Pedro R, Akech S, Fegan G, Maitland K: Changing trends in blood transfusion in children and neonates admitted in Kilifi District Hospital, Kenya. Malaria journal 2010, 9:307. 103. Ogetii GN, Akech S, Jemutai J, Boga M, Kivaya E, Fegan G, Maitland K: Hypoglycaemia in severe malaria, clinical associations and relationship to quinine dosage. BMC infectious diseases 2010, 10:334. 104. Maitland K: Antimicrobials in children admitted to hospital in malaria endemic areas. BMJ 2010, 340:c1818. 105. Khor CC, Vannberg FO, Chapman SJ, Guo H, Wong SH, Walley AJ, Vukcevic D, Rautanen A, Mills TC, Chang KC et al: CISH and susceptibility to infectious diseases. The New England journal of medicine 2010, 362(22):2092-2101. 106. Idro R, Gwer S, Williams TN, Otieno T, Uyoga S, Fegan G, Kager PA, Maitland K, Kirkham F, Neville BG et al: Iron deficiency and acute seizures: results from children living in rural Kenya and a meta-analysis. PloS one 2010, 5(11):e14001. 107. Hassall O, Maitland K, Fegan G, Thitiri J, Pole L, Mwakesi R, Denje D, Wambua K, Mandaliya K, Bates I: The quality of stored umbilical cord and adult-donated whole blood in Mombasa, Kenya. Transfusion 2010, 50(3):611-616. 108. Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A, Chhaganlal KD, Bojang K, Olaosebikan R, Anunobi N, Maitland K et al: Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet 2010, 376(9753):1647-1657. 109. Akech SO, Karisa J, Nakamya P, Boga M, Maitland K: Phase II trial of isotonic fluid resuscitation in Kenyan children with severe malnutrition and hypovolaemia. BMC pediatrics 2010, 10:71. 110. Akech SO, Jemutai J, Timbwa M, Kivaya E, Boga M, Fegan G, Maitland K: Phase II trial on the use of Dextran 70 or starch for supportive therapy in Kenyan children with severe malaria. Critical care medicine 2010, 38(8):1630-1636. 111. Akech S, Ledermann H, Maitland K: Choice of fluids for resuscitation in children with severe infection and shock: systematic review. BMJ 2010, 341:c4416. 112. Talbert A, Atkinson S, Karisa J, Ignas J, Chesaro C, Maitland K: Hypothermia in children with severe malnutrition: low prevalence on the tropical coast of Kenya. Journal of tropical pediatrics 2009, 55(6):413-416. 113. Schloss PD, Westcott SL, Ryabin T, Hall JR, Hartmann M, Hollister EB, Lesniewski RA, Oakley BB, Parks DH, Robinson CJ et al: Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol 2009, 75(23):7537-7541. 114. Olotu A, Ndiritu M, Ismael M, Mohammed S, Mithwani S, Maitland K, Newton CR: Characteristics and outcome of cardiopulmonary resuscitation in hospitalised African children. Resuscitation 2009, 80(1):69-72. 115. Mwaniki MK, Nokes DJ, Ignas J, Munywoki P, Ngama M, Newton CR, Maitland K, Berkley JA: Emergency triage assessment for hypoxaemia in neonates and young children in a Kenyan hospital: an observational study. Bulletin of the World Health Organization 2009, 87(4):263-270. 116. Maitland K: Joint BAPEN and Nutrition Society Symposium on 'Feeding size 0: the science of starvation'. Severe malnutrition: therapeutic challenges and treatment of hypovolaemic shock. The Proceedings of the Nutrition Society 2009, 68(3):274-280. 117. Hassall O, Maitland K, Pole L, Mwarumba S, Denje D, Wambua K, Lowe B, Parry C, Mandaliya K, Bates I: Bacterial contamination of pediatric whole blood transfusions in a Kenyan hospital. Transfusion 2009, 49(12):2594-2598. 118. Berkley JA, Bejon P, Mwangi T, Gwer S, Maitland K, Williams TN, Mohammed S, Osier F, Kinyanjui S, Fegan G et al: HIV infection, malnutrition, and invasive bacterial infection among children with severe malaria. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009, 49(3):336-343. 119. Audran R, Lurati-Ruiz F, Genton B, Blythman HE, Ofori-Anyinam O, Reymond C, Corradin G, Spertini F: The synthetic Plasmodium falciparum circumsporozoite peptide PfCS102 as a malaria vaccine candidate: a randomized controlled phase I trial. PloS one 2009, 4(10):e7304. 120. Nokes DJ, Abwao J, Pamba A, Peenze I, Dewar J, Maghenda JK, Gatakaa H, Bauni E, Scott JA, Maitland K et al: Incidence and clinical characteristics of group A rotavirus infections among children admitted to hospital in Kilifi, Kenya. PLoS medicine 2008, 5(7):e153. 121. Idro R, Williams TN, Gwer S, Uyoga S, Macharia A, Opi H, Atkinson S, Maitland K, Kager PA, Kwiatkowski D et al: Haptoglobin HP2-2 genotype, alpha-thalassaemia and acute seizures in children living in a malaria-endemic area. Epilepsy research 2008, 81(2-3):114-118. 122. Idro R, Gwer S, Kahindi M, Gatakaa H, Kazungu T, Ndiritu M, Maitland K, Neville BG, Kager PA, Newton CR: The incidence, aetiology and outcome of acute seizures in children admitted to a rural Kenyan district hospital. BMC pediatrics 2008, 8:5. 123. Heikens GT, Bunn J, Amadi B, Manary M, Chhagan M, Berkley JA, Rollins N, Kelly P, Adamczick C, Maitland K et al: Case management of HIV-infected severely malnourished children: challenges in the area of highest prevalence. Lancet 2008, 371(9620):1305-1307. 124. Hassall O, Ngina L, Kongo W, Othigo J, Mandaliya K, Maitland K, Bates I: The acceptability to women in Mombasa, Kenya, of the donation and transfusion of umbilical cord blood for severe anaemia in young children. Vox sanguinis 2008, 94(2):125-131. 125. Bejon P, Mohammed S, Mwangi I, Atkinson SH, Osier F, Peshu N, Newton CR, Maitland K, Berkley JA: Fraction of all hospital admissions and deaths attributable to malnutrition among children in rural Kenya. The American journal of clinical nutrition 2008, 88(6):1626-1631. 126. Akech SO, Hassall O, Pamba A, Idro R, Williams TN, Newton CR, Maitland K: Survival and haematological recovery of children with severe malaria transfused in accordance to WHO guidelines in Kilifi, Kenya. Malaria journal 2008, 7:256. 127. Seaton C, Ignas J, Muchohi S, Kokwaro G, Maitland K, Thomson AH: Population pharmacokinetics of a single daily intramuscular dose of gentamicin in children with severe malnutrition. The Journal of antimicrobial chemotherapy 2007, 59(4):681-689. 128. Maitland K, Akech S, Gwer S, Idro R, Fegan G, Eziefula AC, Levin M, Newton CR: Phase III trials required to resolve clinical equipoise over optimal fluid management in children with severe malaria. PLoS clinical trials 2007, 2(2):e2. 129. Khor CC, Vannberg FO, Chapman SJ, Walley A, Aucan C, Loke H, White NJ, Peto T, Khor LK, Kwiatkowski D et al: Positive replication and linkage disequilibrium mapping of the chromosome 21q22.1 malaria susceptibility locus. Genes and immunity 2007, 8(7):570-576. 130. Khor CC, Chapman SJ, Vannberg FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley AJ, Kyrieleis O, Khan A et al: A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nature genetics 2007, 39(4):523-528. 131. Idro R, Ndiritu M, Ogutu B, Mithwani S, Maitland K, Berkley J, Crawley J, Fegan G, Bauni E, Peshu N et al: Burden, features, and outcome of neurological involvement in acute falciparum malaria in Kenyan children. JAMA : the journal of the American Medical Association 2007, 297(20):2232-2240. 132. Bejon P, Berkley JA, Mwangi T, Ogada E, Mwangi I, Maitland K, Williams T, Scott JA, English M, Lowe BS et al: Defining childhood severe falciparum malaria for intervention studies. PLoS medicine 2007, 4(8):e251. 133. Maitland K, Berkley JA, Shebbe M, Peshu N, English M, Newton CR: Children with severe malnutrition: can those at highest risk of death be identified with the WHO protocol? PLoS medicine 2006, 3(12):e500. 134. Maitland K: How do we treat children with severe malaria? Advances in experimental medicine and biology 2006, 582:9-21. 135. Maitland K: Severe malaria: lessons learned from the management of critical illness in children. Trends in parasitology 2006, 22(10):457-462. 136. Idro R, Aketch S, Gwer S, Newton CR, Maitland K: Research priorities in the management of severe Plasmodium falciparum malaria in children. Annals of tropical medicine and parasitology 2006, 100(2):95-108. 137. Casals-Pascual C, Kai O, Lowe B, English M, Williams TN, Maitland K, Newton CR, Peshu N, Roberts DJ: Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12. Malaria journal 2006, 5:101. 138. Casals-Pascual C, Kai O, Cheung JO, Williams S, Lowe B, Nyanoti M, Williams TN, Maitland K, Molyneux M, Newton CR et al: Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo. Blood 2006, 108(8):2569-2577. 139. Bates I, Maitland K: Are laboratory services coming of age in sub-Saharan Africa? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006, 42(3):383-384. 140. Akech S, Gwer S, Idro R, Fegan G, Eziefula AC, Newton CR, Levin M, Maitland K: Volume expansion with albumin compared to gelofusine in children with severe malaria: results of a controlled trial. PLoS clinical trials 2006, 1(5):e21. 141. Williams TN, Wambua S, Uyoga S, Macharia A, Mwacharo JK, Newton CR, Maitland K: Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya. Blood 2005, 106(1):368-371. 142. Scott JA, Mwarumba S, Ngetsa C, Njenga S, Lowe BS, Slack MP, Berkley JA, Mwangi I, Maitland K, English M et al: Progressive increase in antimicrobial resistance among invasive isolates of Haemophilus influenzae obtained from children admitted to a hospital in Kilifi, Kenya, from 1994 to 2002. Antimicrobial agents and chemotherapy 2005, 49(7):3021-3024. 143. Molyneux EM, Maitland K: Intravenous fluids--getting the balance right. The New England journal of medicine 2005, 353(9):941-944. 144. Maitland K, Pamba A, Fegan G, Njuguna P, Nadel S, Newton CR, Lowe B: Perturbations in electrolyte levels in kenyan children with severe malaria complicated by acidosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005, 40(1):9-16. 145. Maitland K, Pamba A, English M, Peshu N, Marsh K, Newton C, Levin M: Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005, 40(4):538-545. 146. Maitland K, Pamba A, English M, Peshu N, Levin M, Marsh K, Newton CR: Pre-transfusion management of children with severe malarial anaemia: a randomised controlled trial of intravascular volume expansion. British journal of haematology 2005, 128(3):393-400. 147. Maitland K, Newton CR: Acidosis of severe falciparum malaria: heading for a shock? Trends in parasitology 2005, 21(1):11-16. 148. Maitland K, Newton C, Marsh K, Levin M: Volume status in severe malaria: no evidence provided for the degree of filling of the intravascular compartment. PLoS medicine 2005, 2(1):e27; author reply e32. 149. Maitland K, Nadel S, Pollard AJ, Williams TN, Newton CR, Levin M: Management of severe malaria in children: proposed guidelines for the United Kingdom. BMJ 2005, 331(7512):337-343. 150. Idro R, Otieno G, White S, Kahindi A, Fegan G, Ogutu B, Mithwani S, Maitland K, Neville BG, Newton CR: Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malaria. Malaria journal 2005, 4:57. 151. Berkley JA, Maitland K, Mwangi I, Ngetsa C, Mwarumba S, Lowe BS, Newton CR, Marsh K, Scott JA, English M: Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study. BMJ 2005, 330(7498):995. 152. Berkley JA, Lowe BS, Mwangi I, Williams T, Bauni E, Mwarumba S, Ngetsa C, Slack MP, Njenga S, Hart CA et al: Bacteremia among children admitted to a rural hospital in Kenya. The New England journal of medicine 2005, 352(1):39-47. 153. Berkley J, Mwangi I, Griffiths K, Ahmed I, Mithwani S, English M, Newton C, Maitland K: Assessment of severe malnutrition among hospitalized children in rural Kenya: comparison of weight for height and mid upper arm circumference. JAMA : the journal of the American Medical Association 2005, 294(5):591-597. 154. Bejon P, Mwangi I, Ngetsa C, Mwarumba S, Berkley JA, Lowe BS, Maitland K, Marsh K, English M, Scott JA: Invasive Gram-negative bacilli are frequently resistant to standard antibiotics for children admitted to hospital in Kilifi, Kenya. The Journal of antimicrobial chemotherapy 2005, 56(1):232-235. 155. Pamba A, Maitland K: Fluid management of severe falciparum malaria in African children. Tropical doctor 2004, 34(2):67-70. 156. Pamba A, Maitland K: Capillary refill: prognostic value in Kenyan children. Archives of disease in childhood 2004, 89(10):950-955. 157. Otieno H, Were E, Ahmed I, Charo E, Brent A, Maitland K: Are bedside features of shock reproducible between different observers? Archives of disease in childhood 2004, 89(10):977-979. 158. Musumba CO, Pamba AO, Sasi PA, English M, Maitland K: Salicylate poisoning in children: report of three cases. East African medical journal 2004, 81(3):159-163. 159. Maitland K, Pamba A, Newton CR, Lowe B, Levin M: Hypokalemia in children with severe falciparum malaria. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2004, 5(1):81-85. 160. Maitland K, Newton C, English M: Intravenous fluids for seriously ill children. Lancet 2004, 363(9404):242-243. 161. Maitland K, Molyneux M: Malaria. Advances in experimental medicine and biology 2004, 549:125-134. 162. Maitland K, Marsh K: Pathophysiology of severe malaria in children. Acta tropica 2004, 90(2):131-140. 163. Maitland K, Makanga M, Williams TN: Falciparum malaria: current therapeutic challenges. Current opinion in infectious diseases 2004, 17(5):405-412. 164. Maitland K, Bunce M, Harding RM, Barnardo MC, Clegg JB, Welsh K, Bowden DK, Williams TN: HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia. Tissue antigens 2004, 64(6):678-686. 165. Berkley JA, Brent A, Mwangi I, English M, Maitland K, Marsh K, Peshu N, Newton CR: Mortality among Kenyan children admitted to a rural district hospital on weekends as compared with weekdays. Pediatrics 2004, 114(6):1737-1738; author reply 1738. 166. Maitland K, Pamba A, Newton CR, Levin M: Response to volume resuscitation in children with severe malaria. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2003, 4(4):426-431. 167. Maitland K, Levin M, English M, Mithwani S, Peshu N, Marsh K, Newton CR: Severe P. falciparum malaria in Kenyan children: evidence for hypovolaemia. QJM : monthly journal of the Association of Physicians 2003, 96(6):427-434. 168. Maitland K, Bejon P, Newton CR: Malaria. Current opinion in infectious diseases 2003, 16(5):389-395. 169. Goodman A, Williams TN, Maitland K: Ciguatera poisoning in Vanuatu. The American journal of tropical medicine and hygiene 2003, 68(2):263-266. 170. Maitland K, Kyes S, Williams TN, Newbold CI: Genetic restriction of Plasmodium falciparum in an area of stable transmission: an example of island evolution? Parasitology 2000, 120 ( Pt 4):335-343. 171. Maitland K: Temporal association of chickenpox and meningococcal disease in children: a report of three cases. Acta Paediatr 2000, 89(6):744-745. 172. Williams TN, Maitland K, Rees DC, Peto TE, Bowden DK, Weatherall DJ, Clegg JB: Reduced soluble transferrin receptor concentrations in acute malaria in Vanuatu. The American journal of tropical medicine and hygiene 1999, 60(5):875-878. 173. Williams TN, Maitland K: Reply from williams and maitland. Parasitol Today 1999, 15(4):167-168. 174. Williams TN, Maitland K, Martin PM, Weatherall DJ, Clegg JB: Splenic size in homozygous alpha+ thalassaemia. British journal of haematology 1998, 100(3):611-612. 175. Rees DC, Williams TN, Maitland K, Clegg JB, Weatherall DJ: Alpha thalassaemia is associated with increased soluble transferrin receptor levels. British journal of haematology 1998, 103(2):365-369. 176. Maitland K, Williams TN: Malaria mortality: the pacific enigma. Parasitol Today 1998, 14(7):258-259. 177. Maitland K, Williams T: Reply. Parasitol Today 1998, 14(7):293. 178. Barnardo MC, Welsh KI, Vilches C, Maitland K, Bunce M: Allele-specific HLA-B*15 typing by PCR-SSP and its application to four distinct ethnic populations. Tissue antigens 1998, 51(3):293-300. 179. Williams TN, Maitland K, Phelps L, Bennett S, Peto TE, Viji J, Timothy R, Clegg JB, Weatherall DJ, Bowden DK: Plasmodium vivax: a cause of malnutrition in young children. QJM : monthly journal of the Association of Physicians 1997, 90(12):751-757. 180. Maitland K, Williams TN, Peto TE, Day KP, Clegg JB, Weatherall DJ, Bowden DK: Absence of malaria-specific mortality in children in an area of hyperendemic malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 1997, 91(5):562-566. 181. Maitland K, Williams TN, Newbold CI: Plasmodium vIvax and P. falciparum: Biological interactions and the possibility of cross-species immunity. Parasitol Today 1997, 13(6):227-231. 182. Maitland K, Williams TN, Kotecka BM, Edstein MD, Rieckmann KH: Plasma chloroquine concentrations in young and older malaria patients treated with chloroquine. Acta tropica 1997, 66(3):155-161. 183. Williams TN, Maitland K, Ganczakowski M, Peto TE, Clegg JB, Weatherall DJ, Bowden DK: Red blood cell phenotypes in the alpha + thalassaemias from early childhood to maturity. British journal of haematology 1996, 95(2):266-272. 184. Williams TN, Maitland K, Bennett S, Ganczakowski M, Peto TE, Newbold CI, Bowden DK, Weatherall DJ, Clegg JB: High incidence of malaria in alpha-thalassaemic children. Nature 1996, 383(6600):522-525. 185. Maitland K, Williams TN, Bennett S, Newbold CI, Peto TE, Viji J, Timothy R, Clegg JB, Weatherall DJ, Bowden DK: The interaction between Plasmodium falciparum and P. vivax in children on Espiritu Santo island, Vanuatu. Transactions of the Royal Society of Tropical Medicine and Hygiene 1996, 90(6):614-620. 186. Bryan JH, Burwell C, Maitland K, Williams T: Culicine mosquitoes (Diptera: Culicidae) attracted to humans on Espiritu Santo, Vanuatu. Medical and veterinary entomology 1996, 10(1):101-102. 187. 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"""0"6"8"""" #&#(#S#s#u##### $ $+$1$4$$$$$$$)%N%P%`%f%h%%%%%%%%X&Z&j&p&r&&-'/'f'h'_h'_5mHnHuh'_h'_mHnHuh'_h'_6mHnHuU%&|'}(7))*+,-h]hgdY^T &`#$gdY^TgdY^Tgd* "0^`0gd'_f'l'n''#(%(h(n(p(())")()*){))))))X******W++++++&,,,,,,-q-s-----]_~~ hD.h?|@CJOJQJ^JaJ)jhD.hBCJOJQJU^JaJUh'_h'_6mHnHuh'_h'_5mHnHuh'_h'_mHnHuBMalaria sporozoite rates for Anopheles farauti s.s. Laveran (Diptera: culicidae) from Vanuatu. Annals of tropical medicine and parasitology 1995, 89(3):305-307. 188. Ganczakowski M, Bowden DK, Maitland K, Williams TN, O'Shaughnessy D, Viji J, Lucassen A, Clegg JB, Weatherall DJ: Thalassaemia in Vanuatu, south-west Pacific: frequency and haematological phenotypes of young children. British journal of haematology 1995, 89(3):485-495. 189. Brindle PM, Maitland K, Williams TN, Ganczakowski ME: A survey for the rare blood group antigen variants, En(a-), Gerbich negative and Duffy negative on Espiritu Santo, Vanuatu in the South Pacific. Human heredity 1995, 45(4):211-214.      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Department of Infectious Diseases, Imperial College, London, UK.Plasma Plasmodium falciparum Histidine-Rich Protein-2 concentrations in children with malaria infections of differing severity in Kilifi, KenyaClin Infect DisClin Infect DisClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020/08/11Plasmodium falciparum Histidine-Rich Protein-2MalariaPfHRP2parasite biomasssequestration2020Aug 91537-6591 (Electronic) 1058-4838 (Linking)32772115https://www.ncbi.nlm.nih.gov/pubmed/3277211510.1093/cid/ciaa1141Olupot-Olupot202070870870817Olupot-Olupot, P.Wabwire, H.Ndila, C.Adong, R.Ochen, L.Amorut, D.Abongo, G.Okalebo, C. B.Akello, S. R.Oketcho, J. B.Okiror, W.Asio, S.Odiit, A.Alaroker, F.Nyutu, G.Maitland, K.Williams, T. N.Mbale Clinical Research Institute, Mbale, Uganda. Faculty of Health Sciences, Busitema University, Mbale, Uganda. Soroti Regional Referral Hospital, Soroti, Uganda. Atutur District Hospital, Atutur, Uganda. 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Department of Neurological Surgery, University of Pittsburgh, PA, USA. Department of Electrical and Computer Engineering, University of Alabama, Tuscaloosa, AL, USA. Department of Foods and Nutrition, University of Georgia, Athens, GA, USA. KEMRI Wellcome Trust Programme, Kilifi, Kenya. Department of Nutrition and Food Science, University of Ghana, Legon-Accra, Ghana. Department of Pediatrics, Section of Endocrinology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. Mbale Clinical Research Institute, Mbale Regional Referral and Teaching Hospital, Mbale, Uganda.Development and Validation of an Objective, Passive Dietary Assessment Method for Estimating Food and Nutrient Intake in Households in Low- and Middle-Income Countries: A Study ProtocolCurr Dev NutrCurr Dev Nutrnzaa020422020/02/27assessmentcameradevicesdietaryfoodhouseholdintakenutrientundernutritionwearable2020Feb2475-2991 (Electronic) 2475-2991 (Linking)32099953https://www.ncbi.nlm.nih.gov/pubmed/32099953PMC703120710.1093/cdn/nzaa020Alhazzani202070370370317Alhazzani, W.Moller, M. H.Arabi, Y. M.Loeb, M.Gong, M. N.Fan, E.Oczkowski, S.Levy, M. M.Derde, L.Dzierba, A.Du, B.Aboodi, M.Wunsch, H.Cecconi, M.Koh, Y.Chertow, D. S.Maitland, K.Alshamsi, F.Belley-Cote, E.Greco, M.Laundy, M.Morgan, J. S.Kesecioglu, J.McGeer, A.Mermel, L.Mammen, M. J.Alexander, P. E.Arrington, A.Centofanti, J. E.Citerio, G.Baw, B.Memish, Z. A.Hammond, N.Hayden, F. G.Evans, L.Rhodes, A.Department of Medicine, McMaster University, Hamilton, Canada. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada. Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, 4131, Copenhagen, Denmark. Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI), Copenhagen, Denmark. Intensive Care Department, Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi Arabia. Division of Critical Care Medicine, Division of Pulmonary Medicine, Department of Medicine, Montefiore Healthcare System/Albert Einstein College of Medicine, Bronx, NY, USA. Interdepartmental Division of Critical Care Medicine, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada. Warren Alpert School of Medicine, Brown University, Providence, RI, USA. Rhode Island Hospital, Providence, RI, USA. Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands. Department of Pharmacy, NewYork-Presbyterian Hospital, Columbia University Irving Medical Center, New York, NY, USA. Medical ICU, Peking Union Medical College Hospital, 1 Shuai Fu Yuan, Beijing, 100730, China. Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. Department of Anesthesia and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. Department of Anesthesia and Intensive Care, Humanitas Clinical and Research Center, Rozzano, Milan, Italy. Department of Biomedical Science, Humanitas University, Pieve Emanuele, Milan, Italy. Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Critical Care Medicine Department, National Institutes of Health Clinical Center and Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Baltimore, USA. Faculty of Medicine, Imperial College, London, UK. Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates. Population Health Research Institute, Hamilton, Canada. Microbiology and Infection Control, St George's University Hospitals NHS Foundation Trust & St George's University of London, London, UK. Emory University Hospital, Atlanta, USA. Division of Infectious Diseases, University of Toronto, Toronto, Canada. Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, USA. GUIDE Research Methods Group, Hamilton, Canada. Houston Children's Hospital, Baylor College of Medicine, Houston, USA. Department of Anesthesia, McMaster University, Hamilton, Canada. Department of Medicine and Surgery, Milano-Bicocca University, Milan, Italy. ASST-Monza, Desio and San Gerardo Hospital, Monza, Italy. Department of Emergency Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia. Director, Research and Innovation Centre, King Saud Medical City, Ministry of Health, Riyadh, Kingdom of Saudi Arabia. Critical Care Division, The George Institute for Global Health and UNSW, Sydney, Australia. Malcolm Fisher Department of Intensive Care, Royal North Shore Hospital, Sydney, Australia. Division of Infectious Diseases and International Health, Department of Medicine, University, of Virginia, School of Medicine, Charlottesville, VA, USA. Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, USA. 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Center for Tropical Medicine & Global Health, University of Oxford, Oxford, UK.Mortality after inpatient treatment for diarrhea in children: a cohort studyBMC MedBMC Med201712019/01/29Child, PreschoolCohort StudiesDeveloping CountriesDiarrhea/etiology/*mortalityFemaleHospitalizationHumansInfantInpatientsKenya/epidemiologyMalePatient DischargePneumonia/mortalityRetrospective StudiesRisk Factors*Africa*Children*Diarrhea*Inpatient*Kenya*Mortality*Post-discharge2019Jan 281741-7015 (Electronic) 1741-7015 (Linking)30686268https://www.ncbi.nlm.nih.gov/pubmed/30686268PMC634864010.1186/s12916-019-1258-0Silaba201965265265217Silaba, M.Ooko, M.Bottomley, C.Sande, J.Benamore, R.Park, K.Ignas, J.Maitland, K.Mturi, N.Makumi, A.Otiende, M.Kagwanja, S.Safari, S.Ochola, V.Bwanaali, T.Bauni, E.Gleeson, F.Deloria Knoll, M.Adetifa, I.Marsh, K.Williams, T. N.Kamau, T.Sharif, S.Levine, O. S.Hammitt, L. L.Scott, J. A. G.KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. Aga Khan University Hospital, Nairobi, Kenya. Oxford University Hospitals NHS Foundation Trust, Oxford, UK. KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Imperial College, London, UK. KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Kilifi County Hospital, Kilifi, Kenya. Kilifi County Hospital, Kilifi, Kenya. KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Oxford University, Oxford, UK. Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Oxford University, Oxford, UK. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA. KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Imperial College, London, UK; INDEPTH Network, Accra, Ghana. Ministry of Health, Nairobi, Kenya. The Bill & Melinda Gates Foundation, Seattle, WA, USA. KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA. KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK; Oxford University, Oxford, UK; INDEPTH Network, Accra, Ghana. Electronic address: anthony.scott@lshtm.ac.uk.Effect of 10-valent pneumococcal conjugate vaccine on the incidence of radiologically-confirmed pneumonia and clinically-defined pneumonia in Kenyan children: an interrupted time-series analysisLancet Glob HealthLancet Glob Healthe337-e346732019/02/212019Mar2214-109X (Electronic) 2214-109X (Linking)30784634https://www.ncbi.nlm.nih.gov/pubmed/30784634PMC637982310.1016/S2214-109X(18)30491-1Passmore201965365365317Passmore, M. R.Obonyo, N. G.Byrne, L.Boon, A. C.Diab, S. D.Dunster, K. R.Fung, Y. L.Spanevello, M. M.Fauzi, M. H.Pedersen, S. E.Simonova, G.Anstey, C. M.Shekar, K.Tung, J. P.Maitland, K.Fraser, J. F.Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia; University of Queensland, Brisbane, Australia. Electronic address: M.Passmore@uq.edu.au. Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia; KEMRI-Wellcome Trust Research Programme, Kenya. Electronic address: gnchafatso@gmail.com. Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia; Intensive Care Unit, The Canberra Hospital, Canberra, Australia. Electronic address: liambyrne.syd@gmail.com. Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia; University of Queensland, Brisbane, Australia. Electronic address: c.boon0207@gmail.com. Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia. Electronic address: sara_diab5@hotmail.com. Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia; Queensland University of Technology, Brisbane, Australia. Electronic address: Kimble.Dunster@health.qld.gov.au. Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia; School of Health and Sport Sciences, University of the Sunshine Coast, Sippy Downs, Australia. Electronic address: ylfung@usc.edu.au. University of Queensland, Brisbane, Australia; Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, Australia. Electronic address: mmspanevello@gmail.com. School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia. Electronic address: hashairi@usm.my. Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia. Electronic address: sanne.pedersen.work@gmail.com. Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia; University of Queensland, Brisbane, Australia; Research and Development, Australian Red Cross Blood Service, Brisbane, Australia. Electronic address: GSimonova@redcrossblood.org.au. Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia; Sunshine Coast University Hospital Intensive Care, Birtinya, Australia. Electronic address: Chris.Anstey@health.qld.gov.au. Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia. Electronic address: kiran.shekar@health.qld.gov.au. Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia; Research and Development, Australian Red Cross Blood Service, Brisbane, Australia. Electronic address: JTung@redcrossblood.org.au. KEMRI-Wellcome Trust Research Programme, Kenya; Wellcome Trust Centre for Clinical Tropical Medicine and Department of Paediatrics, Faculty of Medicine, Imperial College, London, UK. Electronic address: kathryn.maitland@gmail.com. Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia; University of Queensland, Brisbane, Australia. Electronic address: j.fraser@uq.edu.au.Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shockThromb ResThromb Res39-451762019/02/19CoagulationCoagulation factorsFibrinogenSepsisThromboelastometry2019Apr1879-2472 (Electronic) 0049-3848 (Linking)30776686https://www.ncbi.nlm.nih.gov/pubmed/3077668610.1016/j.thromres.2019.02.015Obonyo201964464464417Obonyo, N. G.Byrne, L.Tung, J. P.Simonova, G.Diab, S. D.Dunster, K. R.Passmore, M. R.Boon, A. C.See Hoe, L.Engkilde-Pedersen, S.Esguerra-Lallen, A.Fauzi, M. H.Pimenta, L. P.Millar, J. E.Fanning, J. P.Van Haren, F.Anstey, C. M.Cullen, L.Suen, J.Shekar, K.Maitland, K.Fraser, J. F.Critical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia. IDeAL/KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. The Canberra Hospital Intensive Care, Garran, ACT, Australia. Australia National University, Canberra, ACT, Australia. Australian Red Cross Blood Service, Kelvin Grove, Brisbane, Queensland, Australia. University of Queensland, Brisbane, QLD, Australia. Queensland University of Technology, Brisbane City, QLD Australia. School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia. The University of Canberra, Bruce, ACT, Australia. Sunshine Coast University Hospital Intensive Care, Birtinya, Qld, Australia. Royal Brisbane and Women's Hospital, Herston, QLD, Australia. Adult Intensive Care, The Prince Charles Hospital, Chermside, Brisbane, QLD, Australia. Department of Paediatrics, Faculty of Medicine, Imperial College London, United Kingdom.Pre-clinical study protocol: Blood transfusion in endotoxaemic shockMethodsXMethodsX1124-113262019/06/14Blood transfusionEndotoxaemic shockGuidelinesHaemoglobin thresholdPacked red blood cells (PRBCs)SepsisStorage duration20192215-0161 (Print) 2215-0161 (Linking)31193460https://www.ncbi.nlm.nih.gov/pubmed/31193460PMC652971310.1016/j.mex.2019.05.005Njuguna201963763763717Njuguna, P.Maitland, K.Nyaguara, A.Mwanga, D.Mogeni, P.Mturi, N.Mohammed, S.Mwambingu, G.Ngetsa, C.Awuondo, K.Lowe, B.Adetifa, I.Scott, J. A. G.Williams, T. N.Atkinson, S.Osier, F.Snow, R. W.Marsh, K.Tsofa, B.Peshu, N.Hamaluba, M.Berkley, J. A.Newton, C. R. J.Fondo, J.Omar, A.Bejon, P.KEMRI-Wellcome Trust Research Programme, CGMR-C, KEMRI, PO Box 230, Kilifi, Kenya. Department of Paediatrics, Faculty of Medicine, Imperial College, London, UK. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. London School of Hygiene and Tropical Medicine, London, UK. Department of Paediatrics, University of Oxford, Oxford, UK. Department of Psychiatry, University of Oxford, Oxford, UK. Kilifi County Department of Health, Kilifi, Kenya. KEMRI-Wellcome Trust Research Programme, CGMR-C, KEMRI, PO Box 230, Kilifi, Kenya. pbejon@kemri-wellcome.org.Observational study: 27 years of severe malaria surveillance in Kilifi, KenyaBMC MedBMC Med1241712019/07/10AfricaLongitudinal surveillanceMortalitySecular trendSevere malaria2019Jul 81741-7015 (Electronic) 1741-7015 (Linking)31280724https://www.ncbi.nlm.nih.gov/pubmed/31280724PMC661325510.1186/s12916-019-1359-9Maitland201966366366317Maitland, K.Olupot-Olupot, P.Kiguli, S.Chagaluka, G.Alaroker, F.Opoka, R. O.Mpoya, A.Walsh, K.Engoru, C.Nteziyaremye, J.Mallewa, M.Kennedy, N.Nakuya, M.Namayanja, C.Kayaga, J.Nabawanuka, E.Sennyondo, T.Aromut, D.Kumwenda, F.Musika, C. W.Thomason, M. J.Bates, I.von Hensbroek, M. B.Evans, J. A.Uyoga, S.Williams, T. N.Frost, G.George, E. C.Gibb, D. M.Walker, A. S.Tract trial groupDepartment of Medicine, Imperial College London, London, UK; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya. Electronic address: k.maitland@imperial.ac.uk. Busitema University Faculty of Health Sciences, Mbale Campus and Mbale Regional Referral Hospital Mbale, Mbale, Uganda. Department of Paediatrics, Makerere University and Mulago Hospital, Kampala, Uganda. College of Medicine, and Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi. Soroti Regional Referral Hospital, Soroti, Uganda. Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya. Nutrition Research Section, Imperial College London, London, UK. College of Medicine, and Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; School of Medicine, Dentistry and Biomedical Science, Queen's University, Belfast, UK. Medical Research Council Clinical Trials Unit at University College London. Liverpool School of Tropical Medicine and Hygiene, Liverpool, UK. Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands. Department of Paediatrics, University Hospital of Wales, Cardiff, UK. Department of Medicine, Imperial College London, London, UK; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trialLancet Glob HealthLancet Glob Healthe1435-e14477102019/09/21*AnemiaChildDietary SupplementsHumansInfantMalawiPatient Discharge*Trimethoprim, Sulfamethoxazole Drug CombinationUganda2019Oct2214-109X (Electronic) 2214-109X (Linking)31537373https://www.ncbi.nlm.nih.gov/pubmed/31537373PMC702499910.1016/S2214-109X(19)30345-6Maitland201964064064017Maitland, K.Olupot-Olupot, P.Kiguli, S.Chagaluka, G.Alaroker, F.Opoka, R. O.Mpoya, A.Engoru, C.Nteziyaremye, J.Mallewa, M.Kennedy, N.Nakuya, M.Namayanja, C.Kayaga, J.Uyoga, S.Kyeyune Byabazaire, D.M'Baya, B.Wabwire, B.Frost, G.Bates, I.Evans, J. A.Williams, T. N.Saramago Goncalves, P.George, E. C.Gibb, D. M.Walker, A. S.Tract GroupFrom the Department of Medicine (K.M., T.N.W.) and Nutrition Research Section (G.F.), Imperial College London, and the Medical Research Council Clinical Trials Unit at University College London (E.C.G., D.M.G., A.S.W.), London, the School of Medicine, Dentistry, and Biomedical Science, Queen's University, Belfast (N.K.), the Liverpool School of Tropical Medicine and Hygiene, Liverpool (I.B.), the Department of Pediatrics, University Hospital of Wales, Cardiff (J.A.E.), and the Centre for Health Economics, University of York, York (P.S.G.) - all in the United Kingdom; Busitema University Faculty of Health Sciences, Mbale Campus, Mbale Regional Referral Hospital (P.O.-O., J.N., C.N.), and the Mbale Blood Transfusion Services (B.W.), Mbale, the Department of Pediatrics, Makerere University and Mulago Hospital (S.K., R.O.O., J.K.), and the Uganda Blood Transfusion Services, National Blood Transfusion Services (D.K.B.), Kampala, and Soroti Regional Referral Hospital, Soroti (F.A., C.E., M.N.) - all in Uganda; the Kenya Medical Research Institute-Wellcome Trust Research Program, Kilifi (K.M., A.M., S.U., T.N.W.); and the College of Medicine and the Malawi-Liverpool-Wellcome Trust Clinical Research Program (G.C., M.M., N.K.) and the Malawi Blood Transfusion Services (B.M.) - all in Blantyre, Malawi.Transfusion Volume for Children with Severe Anemia in AfricaN Engl J MedN Engl J MedThe New England journal of medicine420-43138152019/08/01Anemia/complications/mortality/*therapy*Blood Transfusion/economicsChildChild, PreschoolCost-Benefit AnalysisFemaleFever/complicationsFollow-Up StudiesHealth Care CostsHemoglobins/*analysisHumansInfantLength of Stay/economicsMalaria/complicationsMalawi/epidemiologyMalePatient Readmission/statistics & numerical dataTransfusion Reaction/epidemiologyUganda/epidemiology2019Aug 11533-4406 (Electronic) 0028-4793 (Linking)31365800https://www.ncbi.nlm.nih.gov/pubmed/3136580010.1056/NEJMoa1900100Maitland201966066066017Maitland, KathrynOhuma, Eric OMpoya, AyubUyoga, SophieHassall, OliverWilliams, Thomas NInforming thresholds for paediatric transfusion in Africa: the need for a trialWellcome Open ResearchWellcome Open Research42019Maitland201964164164117Maitland, K.Kiguli, S.Olupot-Olupot, P.Engoru, C.Mallewa, M.Saramago Goncalves, P.Opoka, R. O.Mpoya, A.Alaroker, F.Nteziyaremye, J.Chagaluka, G.Kennedy, N.Nabawanuka, E.Nakuya, M.Namayanja, C.Uyoga, S.Kyeyune Byabazaire, D.M'Baya, B.Wabwire, B.Frost, G.Bates, I.Evans, J. A.Williams, T. N.George, E. C.Gibb, D. M.Walker, A. S.Tract GroupFrom the Department of Pediatrics (K.M., T.N.W.) and Nutrition Research Section (G.F.), Imperial College London, and the Medical Research Council Clinical Trials Unit at University College London (E.C.G., D.M.G., A.S.W.), London, the Centre for Health Economics, University of York, York (P.S.G.), the School of Medicine, Dentistry, and Biomedical Science, Queen's University, Belfast (N.K.), Liverpool School of Tropical Medicine and Hygiene, Liverpool (I.B.), and the Department of Pediatrics, University Hospital of Wales, Cardiff (J.A.E.) - all in the United Kingdom; the Department of Pediatrics, Makerere University and Mulago Hospital (S.K., R.O.O., E.N.), and the Uganda Blood Transfusion Services (BTS), National BTS (D.K.B.), Kampala, Busitema University Faculty of Health Sciences, Mbale Campus and Mbale Regional Referral Hospital (P.O.-O., J.N., C.N.), and Mbale BTS (B.W.), Mbale, and the Soroti Regional Referral Hospital, Soroti (C.E., F.A., M.N.) - all in Uganda; the College of Medicine and Malawi-Liverpool-Wellcome Trust Clinical Research Program (M.M., G.C.). and Malawi BTS (B.M.), Blantyre, Malawi; and the Kenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya (K.M., A.M. S.U., T.N.W.).Immediate Transfusion in African Children with Uncomplicated Severe AnemiaN Engl J MedN Engl J MedThe New England journal of medicine407-41938152019/08/01Anemia/complications/mortality/*therapy*Blood Transfusion/economicsChildChild, PreschoolCost-Benefit AnalysisFemaleFollow-Up StudiesHealth Care CostsHemoglobins/*analysisHumansInfantLength of Stay/economicsMalaria/complicationsMalawi/epidemiologyMalePatient Readmission/statistics & numerical data*Time-to-TreatmentTransfusion Reaction/epidemiologyUganda/epidemiology2019Aug 11533-4406 (Electronic) 0028-4793 (Linking)31365799https://www.ncbi.nlm.nih.gov/pubmed/3136579910.1056/NEJMoa1900105Maitland201966266266217Maitland, K.Gibb, D. M.Babiker, A.Feast trial teamDepartment of Medicine, Imperial College London, St Mary's Campus, London W2 1PG, UK. Electronic address: k.maitland@imperial.ac.uk. Medical Research Council Clinical Trials Unit at University College London, London, UK.Secondary re-analysis of the FEAST trialLancet Respir MedLancet Respir Mede297102019/09/27*Albumins2019Oct2213-2619 (Electronic) 2213-2600 (Linking)31556398https://www.ncbi.nlm.nih.gov/pubmed/3155639810.1016/S2213-2600(19)30272-3Maitland201965665665617Maitland, K.Department of Paediatrics, Faculty of Medicine, Imperial College London, London, UK. Clinical Trial Facility, KEMRI Wellcome Trust Research Programme, Kilifi, Kenya.Emergency fluid bolus therapy studies: first do no harmArch Dis ChildArch Dis ChildArchives of disease in childhood409-41010452018/09/30clinical trialsevidence based medicinepaediatric practicetropical paediatrics2019May1468-2044 (Electronic) 0003-9888 (Linking)30266877https://www.ncbi.nlm.nih.gov/pubmed/3026687710.1136/archdischild-2018-315885Houston201964364364317Houston, K. A.Gibb, J.Olupot-Olupot, P.Obonyo, N.Mpoya, A.Nakuya, M.Muhindo, R.Uyoga, S.Evans, J. A.Connon, R.Gibb, D. M.George, E. C.Maitland, K.Department of Paediatrics, Faculty of Medicine, St Mary's Campus, Norfolk Place, Imperial College, London, W2 1PG, UK. KEMRI-Wellcome Trust Research Programme, PO Box 230, Kilifi, Kenya. Mbale Clinical Research Institute, Pallisa Road, PO Box 291, Mbale, Uganda. Mbale Regional Referral Hospital, Pallisa Road, PO Box 291, Mbale, Uganda. Soroti Regional Referral Hospital, PO Box 289, Soroti, Uganda. Department of Paediatrics, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, Wales, UK. MRC Clinical Trials Unit at UCL 90 High Holborn, 2nd Floor, London, WC1V 6LJ, UK. Department of Paediatrics, Faculty of Medicine, St Mary's Campus, Norfolk Place, Imperial College, London, W2 1PG, UK. K.maitland@imperial.ac.uk. KEMRI-Wellcome Trust Research Programme, PO Box 230, Kilifi, Kenya. K.maitland@imperial.ac.uk.Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydrationBMC MedBMC Med1221712019/07/02African childrenClinical trialIntravenous fluidsRehydrationSevere dehydration2019Jul 11741-7015 (Electronic) 1741-7015 (Linking)31256761https://www.ncbi.nlm.nih.gov/pubmed/31256761PMC660088410.1186/s12916-019-1356-zGeorge201969169169117George, E. C.Kiguli, S.Olupot, P. O.Opoka, R. O.Engoru, C.Akech, S. O.Nyeko, R.Mtove, G.Mpoya, A.Thomason, M. J.Crawley, J.Evans, J. A.Gibb, D. M.Babiker, A. G.Maitland, K.Walker, A. S.Medical Research Council Clinical Trials Unit (MRC CTU) at UCL, Institute of Clinical Trials and Methodology, UCL, London, UK. elizabeth.george@ucl.ac.uk. Department of Paediatrics, Mulago Hospital, Makerere University, Kampala, Uganda. Mbale Clinical Research Institute, Mbale, Uganda. Kilifi Clinical Trials Facility, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. Department of Paediatrics, St Mary's Hospital, Lacor, Gulu, Uganda. Department of Paediatrics, Joint Malaria Programme, Teule Hospital, Teule, Tanzania. Medical Research Council Clinical Trials Unit (MRC CTU) at UCL, Institute of Clinical Trials and Methodology, UCL, London, UK. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Department of Paediatrics, University Hospital of Wales, Cardiff, UK. Department of Paediatrics, Faculty of Medicine, Imperial College, Kensington, London, UK.Mortality risk over time after early fluid resuscitation in African childrenCrit CareCrit Care3772312019/11/30Child*Fluid TherapyHumans*InfectionsResuscitationRetrospective StudiesTime*Africa*Fluid resuscitation*Mortality risk*Paediatric shock*Parametric models2019Nov 271466-609X (Electronic) 1364-8535 (Linking)31775837https://www.ncbi.nlm.nih.gov/pubmed/31775837PMC688219910.1186/s13054-019-2619-yDauncey201964564564517Dauncey, J. W.Olupot-Olupot, P.Maitland, K.Wellcome Trust Centre for Clinical Tropical Medicine and Department of Paediatrics, Faculty of Medicine, Imperial College, London, W2 1PG, UK. jdauncey@nhs.net. Department of Paediatrics, Mbale Regional Referral Hospital, Pallisa Road, PO Box 291, Mbale, Uganda. Mbale Clinical Research Institute (MCRI), Plot 29-33 Pallisa Rd, P.O. Box 1966, Mbale, Uganda. Wellcome Trust Centre for Clinical Tropical Medicine and Department of Paediatrics, Faculty of Medicine, Imperial College, London, W2 1PG, UK. KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, PO Box 230, Kilifi, Kenya.Healthcare-provider perceptions of barriers to oxygen therapy for paediatric patients in three government-funded eastern Ugandan hospitals; a qualitative studyBMC Health Serv ResBMC Health Serv ResBMC health services research3351912019/05/28*Attitude of Health PersonnelChild*Health Personnel/educationHealth Services Research*Hospitals, DistrictHumansInterviews as Topic*Oxygen Inhalation Therapy*Pediatrics/educationQualitative ResearchQuality ImprovementSurveys and QuestionnairesUgandaAfricaOxygenPaediatrics2019May 241472-6963 (Electronic) 1472-6963 (Linking)31126269https://www.ncbi.nlm.nih.gov/pubmed/31126269PMC653484710.1186/s12913-019-4129-7Brent201964964964917Brent, B.Obonyo, N.Akech, S.Shebbe, M.Mpoya, A.Mturi, N.Berkley, J. A.Tulloh, R. M. R.Maitland, K.Kenya Medical Research Institute Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya. Department of Paediatrics, Faculty of Medicine, St Mary's Campus, Imperial College, London, United Kingdom. Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. Bristol Royal Hospital for Children, Bristol, United Kingdom.Assessment of Myocardial Function in Kenyan Children With Severe, Acute Malnutrition: The Cardiac Physiology in Malnutrition (CAPMAL) StudyJAMA Netw OpenJAMA Netw Opene191054232019/03/232019Mar 12574-3805 (Electronic) 2574-3805 (Linking)30901050https://www.ncbi.nlm.nih.gov/pubmed/30901050PMC658328110.1001/jamanetworkopen.2019.1054Walsh201858858858817Walsh, K.Calder, N.Olupot-Olupot, P.Ssenyondo, T.Okiror, W.Okalebo, C. B.Muhindo, R.Mpoya, A.Holmes, E.Marchesi, J.Delamare de la Villenaise de Chenevarin, G.Frost, G.Maitland, K.Department of Paediatrics, Imperial College, London, W2 1PG, UK. Section for Nutrition Research, Department of Medicine, Imperial College, London, W12 ONN, UK. Department of Paediatrics, Mbale Regional Referral Hospital, Mbale, PO Box 1966, Uganda. Mbale Clinical Research Institute, Mbale, PO Box 1966, Uganda. Clinical Trials Facility, KEMRI-Wellcome Trust Research Programme, Kilifi, PO Box 230, Kenya. Division of Computational and Systems Medicine, Imperial College, London, SW7 2AZ, UK. Centre for Digestive and Gut Health, Imperial College, London, W2 1NY, UK. Production and Processing Research Department, Campden BRI Group, Chipping Campden, GL55 6LD, UK.Modifying Intestinal Integrity and Micro Biome in Severe Malnutrition with Legume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trialWellcome Open ResWellcome Open Res9532018/10/23African childrenUgandagut-barrier dysfunctionlegume-based fermentable carbohydrates F75 F100 clinical trialnutritional feedssevere malnutrition20182398-502X (Print) 2398-502X (Linking)30345381https://www.ncbi.nlm.nih.gov/pubmed/30345381PMC617155210.12688/wellcomeopenres.14706.1Taylor201856756756717Taylor, W. R.Naw, H. K.Maitland, K.Williams, T. N.Kapulu, M.D'Alessandro, U.Berkley, J. A.Bejon, P.Okebe, J.Achan, J.Amambua, A. N.Affara, M.Nwakanma, D.van Geertruyden, J. P.Mavoko, M.Lutumba, P.Matangila, J.Brasseur, P.Piola, P.Randremanana, R.Lasry, E.Fanello, C.Onyamboko, M.Schramm, B.Yah, Z.Jones, J.Fairhurst, R. M.Diakite, M.Malenga, G.Molyneux, M.Rwagacondo, C.Obonyo, C.Gadisa, E.Aseffa, A.Loolpapit, M.Henry, M. C.Dorsey, G.John, C.Sirima, S. B.Barnes, K. I.Kremsner, P.Day, N. P.White, N. J.Mukaka, M.Mahidol Oxford Tropical Medicine Research Unit (MORU), Mahidol University, 420/6 Rajvithi Road, Rajthevee, Bangkok, 10400, Thailand. bob@tropmedres.ac. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. bob@tropmedres.ac. Division of Tropical and Humanitarian Medicine, University Hospitals of Geneva, Geneva, Switzerland. bob@tropmedres.ac. Mahidol Oxford Tropical Medicine Research Unit (MORU), Mahidol University, 420/6 Rajvithi Road, Rajthevee, Bangkok, 10400, Thailand. KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya. Wellcome Trust Centre for Clinical Tropical Medicine and Department of Paediatrics, Faculty of Medicine, Imperial College, London, UK. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. MRC Unit, Fajara, Banjul, The Gambia. Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK. Global Health Institute, University of Antwerp, Antwerp, Belgium. Department of Tropical Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo. Unite Mixte de Recherche 198, URMITE, IRD, Dakar, Senegal. Institut Pasteur de Madagascar, BP 1274, Antananarivo, Madagascar. Medecins Sans Frontieres, Paris, France. Kinshasa Mahidol Oxford Research Unit, Kinshasa, Democratic Republic of Congo. Kinshasa School of Public Health, Kinshasa, Democratic Republic of Congo. Epicentre, Paris, France. National Malaria Control Programme, Monrovia, Sierra Leone. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. Malaria Research and Training Centre, USTTB, Bamako, Mali. Queen Elizabeth Hospital, Blantyre, Malawi. Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi. National Malaria Control Programme, Kigali, Rwanda. Kenya Medical Research Institute, Kisumu, Kenya. Armauer Hansen Research Institute, Addis Ababa, Ethiopia. Amref Health Africa in Kenya, Nairobi, Kenya. Centre de Recherche Entomologique de Cotonou, Cotonou, Benin. Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Department of Pediatrics, Indiana University, Indianapolis, IN, USA. Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso. Groupe de Recherche Action en Sante (GRAS), Ouagadougou, Burkina Faso. Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa. Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany.Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan AfricaBMC MedBMC Med111612018/01/20AdolescentAdultAfrica South of the SaharaAge FactorsAgedAged, 80 and overAntimalarials/administration & dosage/adverse effects/*therapeutic useChildChild, PreschoolClinical ProtocolsDose-Response Relationship, DrugFemaleGlucosephosphate Dehydrogenase DeficiencyHumansInfantMalaria, Falciparum/drug therapy/*prevention & control/transmissionMaleMiddle AgedPlasmodium falciparumPrimaquine/administration & dosage/adverse effects/*therapeutic useYoung Adult*Age-based dosing*Malaria*Plasmodium falciparum*Primaquine*Transmission blocking2018Jan 181741-7015 (Electronic) 1741-7015 (Linking)29347975https://www.ncbi.nlm.nih.gov/pubmed/29347975PMC577403210.1186/s12916-017-0990-6Siika201868868868817Siika, A.McCabe, L.Bwakura-Dangarembizi, M.Kityo, C.Mallewa, J.Berkley, J.Maitland, K.Griffiths, A.Baleeta, K.Mudzingwa, S.Abach, J.Nathoo, K.Thomason, M. J.Prendergast, A. J.Walker, A. S.Gibb, D. M.Reality Trial TeamMoi University School of Medicine, Eldoret, Kenya. Medical Research Council Clinical Trials Unit at University College London, United Kingdom. University of Zimbabwe Clinical Research Centre, Harare. Joint Clinical Research Centre, Kampala, Uganda. Department/College of Medicine and Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre. Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi. Joint Clinical Research Centre, Mbale. Joint Clinical Research Centre, Gulu, Uganda. Queen Mary University of London, United Kingdom.Late Presentation With HIV in Africa: Phenotypes, Risk, and Risk Stratification in the REALITY TrialClin Infect DisClin Infect DisClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaS140-S14666suppl_22018/03/08AIDS-Related Opportunistic Infections/*drug therapy/*mortalityAdolescentAdultAfrica South of the Sahara/epidemiologyAge FactorsAnti-HIV Agents/therapeutic useAntiretroviral Therapy, Highly Active/*statistics & numerical dataCD4 Lymphocyte Count/statistics & numerical dataChildChild, PreschoolFemaleHivHIV Infections/*drug therapy/*mortalityHumansImmunocompromised HostMalePhenotypeRisk AssessmentRisk Factors2018Mar 41537-6591 (Electronic) 1058-4838 (Linking)29514235https://www.ncbi.nlm.nih.gov/pubmed/29514235PMC585054710.1093/cid/cix1142Post201868968968917Post, F. A.Szubert, A. J.Prendergast, A. J.Johnston, V.Lyall, H.Fitzgerald, F.Musiime, V.Musoro, G.Chepkorir, P.Agutu, C.Mallewa, J.Rajapakse, C.Wilkes, H.Hakim, J.Mugyenyi, P.Walker, A. S.Gibb, D. M.Pett, S. L.Reduction of, EArly mortaLITY in H. I. V. infected adultschildren starting antiretroviral therapy Trial, TeamKing's College Hospital NHS Foundation Trust, London. Medical Research Council Clinical Trials Unit at University College London. Queen Mary University of London. London School of Hygiene and Tropical Medicine. Imperial College Healthcare NHS Trust, London. University College London Great Ormond Street Institute of Child Health, United Kingdom. Joint Clinical Research Centre, Kampala, Uganda. University of Zimbabwe, Harare. Moi University School of Medicine, Eldoret. Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi. Department of Medicine, College of Medicine and Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre. Institute for Global Health, University College London, United Kingdom. Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia.Causes and Timing of Mortality and Morbidity Among Late Presenters Starting Antiretroviral Therapy in the REALITY TrialClin Infect DisClin Infect DisClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaS132-S13966suppl_22018/03/08AIDS-Related Opportunistic Infections/drug therapyAdolescentAdultAfrica South of the Sahara/epidemiologyAgedAnti-Bacterial Agents/administration & dosageAnti-HIV Agents/therapeutic useAnti-Infective Agents/administration & dosage*Antibiotic ProphylaxisAntiretroviral Therapy, Highly Active/*statistics & numerical dataChildChild, PreschoolCryptococcosis/drug therapy/mortalityFemaleHIV Infections/*drug therapy/epidemiology/*mortalityHumansIncidenceMaleMiddle AgedMorbidityTrimethoprim, Sulfamethoxazole Drug Combination/administration & dosageYoung Adult2018Mar 41537-6591 (Electronic) 1058-4838 (Linking)29514234https://www.ncbi.nlm.nih.gov/pubmed/29514234PMC585043010.1093/cid/cix1141Opi201856356356317Opi, D. H.Swann, O.Macharia, A.Uyoga, S.Band, G.Ndila, C. M.Harrison, E. M.Thera, M. A.Kone, A. K.Diallo, D. A.Doumbo, O. K.Lyke, K. E.Plowe, C. V.Moulds, J. M.Shebbe, M.Mturi, N.Peshu, N.Maitland, K.Raza, A.Kwiatkowski, D. P.Rockett, K. A.Williams, T. N.Rowe, J. A.Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya. Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. Centre for Medical Infomatics, Usher Insitute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom. Malaria Research and Training Centre, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali. Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, United States. Lifeshare Blood Centers, Shreveport, United States. Department of Medicine, Imperial College, London, United Kingdom. Wellcome Trust Sanger Institute, Cambridge, United Kingdom.Two complement receptor one alleles have opposing associations with cerebral malaria and interact with alpha(+)thalassaemiaElifeElife72018/04/25AdolescentCase-Control StudiesChildChild, PreschoolFemaleGene FrequencyGenetic Association StudiesHumansInfantInfant, NewbornKenyaMalaria, Cerebral/*genetics/*pathologyMaleMaliModels, Statistical*Polymorphism, GeneticReceptors, Complement 3b/*geneticsalpha-Thalassemia/*genetics*<i>p. falciparum</i>*Alpha thalassaemia*Cerebral malaria*Complement receptor 1*Knops blood group*epidemiology*global health*human*infectious disease*microbiologyKR, TW, JR No competing interests declared2018Apr 252050-084X (Electronic) 2050-084X (Linking)29690995https://www.ncbi.nlm.nih.gov/pubmed/29690995PMC595354110.7554/eLife.31579Ominde201858258258217Ominde, M.Sande, J.Ooko, M.Bottomley, C.Benamore, R.Park, K.Ignas, J.Maitland, K.Bwanaali, T.Gleeson, F.Scott, A.KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. Aga Khan University Hospital, Nairobi, Kenya. Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. Oxford University Hospitals Foundation NHS Trust, Oxford, United Kingdom. Imperial College, London, United Kingdom. Oxford University, Oxford, United Kingdom.Reliability and validity of the World Health Organization reading standards for paediatric chest radiographs used in the field in an impact study of Pneumococcal Conjugate Vaccine in Kilifi, KenyaPLoS OnePLoS OnePloS onee02007151372018/07/26ChildChild, PreschoolFemaleHumansIncidenceInfantKenya/epidemiologyLung/*diagnostic imagingMaleMass Chest X-Ray/methods/*standardsObserver VariationPneumococcal Vaccines/*therapeutic usePneumonia, Pneumococcal/diagnostic imaging/epidemiology/*prevention & controlRadiologists/education/*standardsReproducibility of ResultsSensitivity and SpecificityTreatment OutcomeVaccines, Conjugate/therapeutic useWorld Health Organization20181932-6203 (Electronic) 1932-6203 (Linking)30044834https://www.ncbi.nlm.nih.gov/pubmed/30044834PMC605945910.1371/journal.pone.0200715Olupot-Olupot201864864864817Olupot-Olupot, P.Prevatt, N.Engoru, C.Nteziyaremye, J.Amorut, D.Chebet, M.Senyondo, T.Ongodia, P.Ndila, C. M.Williams, T. N.Maitland, K.Faculty of Medicine, Imperial College London, London, W2 1PG, UK. Department of Paediatric, Busitema University Faculty of Health Sciences, Mbale Campus, Uganda. Mbale Clinical Research Institute, Mbale, Uganda. London School of Tropical Medicine and Hygiene, London, UK. Department of Paediatrics, Soroti Regional Referral Hospital, Soroti, Uganda. Department of Paediatrics, Mbale Regional Referral Hospital, Mbale, Uganda. KEMRI Wellcome Trust Research Programme, Kilifi, PO Box 230, Kenya.Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalised children in Eastern UgandaWellcome Open ResWellcome Open Res13032019/04/02AfricaAnaemiaChildhaemoglobin measurementinterD|D-observer variationmalaria endemicprevalencesensitivity and specificity20182398-502X (Print) 2398-502X (Linking)30854471https://www.ncbi.nlm.nih.gov/pubmed/30854471PMC6402076.210.12688/wellcomeopenres.14801.2Ndila201858358358317Ndila, C. M.Uyoga, S.Macharia, A. W.Nyutu, G.Peshu, N.Ojal, J.Shebe, M.Awuondo, K. O.Mturi, N.Tsofa, B.Sepulveda, N.Clark, T. G.Band, G.Clarke, G.Rowlands, K.Hubbart, C.Jeffreys, A.Kariuki, S.Marsh, K.Mackinnon, M.Maitland, K.Kwiatkowski, D. P.Rockett, K. A.Williams, T. N.Malaria, G. E. N. ConsortiumKEMRI/Wellcome Trust Research Programme, Kilifi, Kenya; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya. London School of Hygiene & Tropical Medicine, London, UK; Centro de Estatistica e Aplicacoes da Universidade de Lisboa, Lisbon, Portugal. London School of Hygiene & Tropical Medicine, London, UK. Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya; Wellcome Sanger Institute, Cambridge, UK. unaffiliated researcher [ResearcherID: L-3155-2013]. KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya; Department of Medicine, Imperial College, St Mary's Hospital, London, UK. Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK; Big Data Institute, University of Oxford, Oxford, UK; Wellcome Sanger Institute, Cambridge, UK. KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya; Department of Medicine, Imperial College, St Mary's Hospital, London, UK. Electronic address: tom.williams@imperial.ac.uk.Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association studyLancet HaematolLancet Haematole333-e345582018/07/24Case-Control StudiesChildChild, PreschoolFemaleGene FrequencyGenetic Predisposition to Disease/*geneticsHumansKenyaMalaria/*geneticsMale*Polymorphism, Genetic2018Aug2352-3026 (Electronic) 2352-3026 (Linking)30033078https://www.ncbi.nlm.nih.gov/pubmed/30033078PMC606967510.1016/S2352-3026(18)30107-8Mallewa201868768768717Mallewa, J.Szubert, A. J.Mugyenyi, P.Chidziva, E.Thomason, M. J.Chepkorir, P.Abongomera, G.Baleeta, K.Etyang, A.Warambwa, C.Melly, B.Mudzingwa, S.Kelly, C.Agutu, C.Wilkes, H.Nkomani, S.Musiime, V.Lugemwa, A.Pett, S. L.Bwakura-Dangarembizi, M.Prendergast, A. J.Gibb, D. M.Walker, A. S.Berkley, J. A.Reality trial teamDepartment/College of Medicine and Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi. Medical Research Council Clinical Trials Unit at University College London, London, UK. Joint Clinical Research Centre, Kampala, Uganda. University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe. Moi University School of Medicine, Eldoret, Kenya. Joint Clinical Research Centre, Gulu, Uganda. Joint Clinical Research Centre, Mbale, Uganda. KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya. Joint Clinical Research Centre, Mbarara, Uganda. Medical Research Council Clinical Trials Unit at University College London, London, UK; The Kirby Institute, University of New South Wales, Sydney, Australia. Queen Mary University of London, London, UK. Medical Research Council Clinical Trials Unit at University College London, London, UK. Electronic address: diana.gibb@ucl.ac.uk. Medical Research Council Clinical Trials Unit at University College London, London, UK. Electronic address: rmjlasw@ucl.ac.uk.Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trialLancet HIVLancet HIVe231-e240552018/04/15AdolescentAdultAfrica South of the SaharaAgedAnti-Infective Agents/administration & dosageAnti-Retroviral Agents/*administration & dosageArachisBody Mass IndexBody WeightChildChild, PreschoolDiet Therapy/*methodsFemaleHIV Infections/*mortality/*therapyHumansMaleMicronutrients/administration & dosageMiddle AgedRaltegravir Potassium/administration & dosageSurvival AnalysisTreatment OutcomeYoung Adult2018May2352-3018 (Electronic) 2352-3018 (Linking)29653915https://www.ncbi.nlm.nih.gov/pubmed/29653915PMC593219010.1016/S2352-3018(18)30038-9Maitland201852752752717Maitland, KathrynKiguli, SarahOpoka, Robert O.Olupot-Olupot, PeterEngoru, CharlesNjuguna, PatriciaBandika, VictorMpoya, AyubBush, AndrewWilliams, Thomas N.Grieve, RichardSadique, ZiaFraser, JohnHarrison, DavidRowan, KathyChildren’s Oxygen Administration Strategies Trial (COAST):  A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumoniaWellcome Open ResearchWellcome Open Research1002201809/01/20182398-502X10.12688/wellcomeopenres.12747.2Macharia201853453453417Macharia, A. W.Mochamah, G.Uyoga, S.Ndila, C. M.Nyutu, G.Makale, J.Tendwa, M.Nyatichi, E.Ojal, J.Shebe, M.Awuondo, K. O.Mturi, N.Peshu, N.Tsofa, B.Scott, J. A. G.Maitland, K.Williams, T. N.KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya. London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom. INDEPTH Network, Accra, Ghana. Faculty of Medicine, Imperial College, St Mary's Hospital, London, W21NY, United Kingdom.The clinical epidemiology of sickle cell anemia In AfricaAm J HematolAm J Hematol363-3709332018Mar1096-8652 (Electronic) 0361-8609 (Linking)29168218https://www.ncbi.nlm.nih.gov/pubmed/2916821810.1002/ajh.24986Lipson201856556556517Lipson, M.Skoglund, P.Spriggs, M.Valentin, F.Bedford, S.Shing, R.Buckley, H.Phillip, I.Ward, G. K.Mallick, S.Rohland, N.Broomandkhoshbacht, N.Cheronet, O.Ferry, M.Harper, T. K.Michel, M.Oppenheimer, J.Sirak, K.Stewardson, K.Auckland, K.Hill, A. V. S.Maitland, K.Oppenheimer, S. J.Parks, T.Robson, K.Williams, T. N.Kennett, D. J.Mentzer, A. J.Pinhasi, R.Reich, D.Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: mlipson@genetics.med.harvard.edu. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; The Francis Crick Institute, London NW1 1AT, UK. School of Archaeology and Anthropology, College of Arts and Social Sciences, The Australian National University, Canberra, ACT 2601, Australia; Vanuatu National Museum, Vanuatu Cultural Centre, P.O. Box 184, Port Vila, Vanuatu. Maison de l'Archeologie et de l'Ethnologie, CNRS, UMR 7041, 92023 Nanterre, France. Vanuatu National Museum, Vanuatu Cultural Centre, P.O. Box 184, Port Vila, Vanuatu; Department of Archaeology and Natural History, College of Asia-Pacific, The Australian National University, Canberra, ACT 2601, Australia. Vanuatu National Museum, Vanuatu Cultural Centre, P.O. Box 184, Port Vila, Vanuatu. Department of Anatomy, Otago Global Health Institute, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand. Department of Archaeology and Natural History, College of Asia-Pacific, The Australian National University, Canberra, ACT 2601, Australia. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA. Department of Anthropology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria; Earth Institute, University College Dublin, Dublin 4, Ireland. Department of Anthropology and Institute for Energy and the Environment, The Pennsylvania State University, University Park, PA 16802, USA. Earth Institute, University College Dublin, Dublin 4, Ireland; Department of Anthropology, Emory University, Atlanta, GA, USA. Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Department of Paediatrics, Faculty of Medicine, Imperial College, St Mary's Hospital, Norfolk Place, Paddington, London W2 1PG, UK. School of Anthropology and Museum Ethnography, University of Oxford, Oxford OX2 6PE, UK. MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Max Planck-Harvard Research Center for the Archaeoscience of the Ancient Mediterranean, Cambridge, MA 02138, USA. Electronic address: reich@genetics.med.harvard.edu.Population Turnover in Remote Oceania Shortly after Initial SettlementCurr BiolCurr Biol1157-1165 e7287LapitaNear OceaniaPacific IslandersRemote Oceaniaancient DNAmigration2018Apr 21879-0445 (Electronic) 0960-9822 (Linking)29501328https://www.ncbi.nlm.nih.gov/pubmed/29501328PMC588256210.1016/j.cub.2018.02.051Kotlyar201853353353317Kotlyar, S.Olupot-Olupot, P.Nteziyaremye, J.Akech, S. O.Uyoga, S.Muhindo, R.Moore, C. L.Maitland, K.Department of Emergency Medicine, Yale School of Medicine, New Haven, CT. London School of Hygiene and Tropical Medicine, London, United Kingdom. Mbale Clinical Research Institute, Mbale Regional Referral Hospital, Mbale, Uganda. Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya. Department of Pediatrics, Faculty of Medicine, Wellcome Trust Centre for Global Health, Imperial College, London, United Kingdom.Assessment of Myocardial Function and Injury by Echocardiography and Cardiac Biomarkers in African Children With Severe Plasmodium falciparum MalariaPediatr Crit Care MedPediatr Crit Care MedPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies179-1851932018Mar1529-7535 (Print) 1529-7535 (Linking)29206727https://www.ncbi.nlm.nih.gov/pubmed/29206727PMC583535910.1097/PCC.0000000000001411Kityo201868668668617Kityo, C.Szubert, A. J.Siika, A.Heyderman, R.Bwakura-Dangarembizi, M.Lugemwa, A.Mwaringa, S.Griffiths, A.Nkanya, I.Kabahenda, S.Wachira, S.Musoro, G.Rajapakse, C.Etyang, T.Abach, J.Spyer, M. J.Wavamunno, P.Nyondo-Mipando, L.Chidziva, E.Nathoo, K.Klein, N.Hakim, J.Gibb, D. M.Walker, A. S.Pett, S. L.Reality trial teamJoint Clinical Research Centre, Kampala, Uganda. Medical Research Council Clinical Trials Unit at University College London, University College London, London, United Kingdom. Moi University School of Medicine, Eldoret, Kenya. Department/College of Medicine, University of Malawi, and Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi. Division of Infection and Immunity, University College London, London, United Kingdom. University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe. Joint Clinical Research Centre, Mbarara, Uganda. KEMRI Wellcome Trust Research Programme, Kilifi, Kenya. Joint Clinical Research Centre, Fort Portal, Uganda. Joint Clinical Research Centre, Gulu, Uganda. University College London Great Ormond Street Institute of Child Health, University College London, London, United Kingdom. Institute for Global Health, University College London, London, United Kingdom. Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia.Raltegravir-intensified initial antiretroviral therapy in advanced HIV disease in Africa: A randomised controlled trialPLoS MedPLoS MedPLoS medicinee100270615122018/12/05AdolescentAdultAfrica/epidemiologyAnti-HIV Agents/*administration & dosageAnti-Retroviral Agents/*administration & dosageChildChild, Preschool*Disease ProgressionDrug Administration ScheduleFemaleFollow-Up StudiesHIV Infections/diagnostic imaging/*drug therapy/*epidemiologyHealth Services Accessibility/trendsHumansKenya/epidemiologyMalawi/epidemiologyMaleRaltegravir Potassium/*administration & dosageUganda/epidemiologyYoung AdultZimbabwe/epidemiology2018Dec1549-1676 (Electronic) 1549-1277 (Linking)30513108https://www.ncbi.nlm.nih.gov/pubmed/30513108PMC6279020 following competing interests: the institution of ASW has received funding from Janssen and Gilead Sciences for DSMB membership and lectures; JH has received funding for advisory board membership from Mylan Pharmaceuticals; all other authors have no other relationships or activities that could appear to have influenced the submitted work.10.1371/journal.pmed.1002706Iro201854654654617Iro, M. A.Sell, T.Brown, N.Maitland, K.Oxford Vaccine Group, Department of Paediatrics and the NIHR Biomedical Research Centre, University of Oxford, Headington, Oxford, OX3 7LE, UK. Department of Paediatrics, Salisbury District Hospital, Salisbury, SP2 8BJ, UK. Department of Child Health, Aga Khan University, Karachi, Pakistan. Department of Paediatrics, Faculty of Medicine, Wellcome Trust Centre for Clinical Tropical Medicine, Imperial College, W2 1PG, London, UK. K.maitland@imperial.ac.uk. Clinical Trials Facility, KEMRI Wellcome Trust Research Programme, PO Box 230, Kilifi, Kenya. K.maitland@imperial.ac.uk.Rapid intravenous rehydration of children with acute gastroenteritis and dehydration: a systematic review and meta-analysisBMC PediatrBMC PediatrBMC pediatrics44181*Acute gastroenteritis*Africa*Asia*Dehydration*Emergency care*Intravenous rehydration*Systematic review2018Feb 91471-2431 (Electronic) 1471-2431 (Linking)29426307https://www.ncbi.nlm.nih.gov/pubmed/29426307PMC580775810.1186/s12887-018-1006-1Houston201856256256217Houston, K. A.George, E. C.Maitland, K.Wellcome Trust Centre for Clinical Tropical Medicine and Department of Paediatrics, Faculty of Medicine, Imperial College, London, W2 1PG, UK. KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, PO Box 230, Kilifi, Kenya. Medical Research Council Clinical Trials Unit (MRC CTU) at University College London (UCL), 90 High Holborn, 2nd Floor, London, WC1V 6XX, UK. Wellcome Trust Centre for Clinical Tropical Medicine and Department of Paediatrics, Faculty of Medicine, Imperial College, London, W2 1PG, UK. k.maitland@imperial.ac.uk. KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, PO Box 230, Kilifi, Kenya. k.maitland@imperial.ac.uk.Implications for paediatric shock management in resource-limited settings: a perspective from the FEAST trialCrit CareCrit Care119221HypotensionIntravenous fluidsPaediatricShockTachycardiaWorld Health Organization (WHO)2018May 41466-609X (Electronic) 1364-8535 (Linking)29728116https://www.ncbi.nlm.nih.gov/pubmed/29728116PMC593602410.1186/s13054-018-1966-4Byrne201857157157117Byrne, L.Obonyo, N. G.Diab, S. D.Dunster, K. R.Passmore, M. R.Boon, A. C.See Hoe, L.Pedersen, S.Hashairi Fauzi, M.Pretti Pimenta, L.Van Haren, F.Anstey, C. M.Cullen, L.Tung, J. P.Shekar, K.Maitland, K.Fraser, J. F.Canberra Hospital, 34381, Intensive Care, Canberra, Australian Capital Territory, Australia. Australian national university, Medical school, Canberra, Australian Capital Territory, Australia ; liambyrne.syd@gmail.com. The Critical care research group, Brisbane, Queensland, Australia. University of Queensland, Medicine, Brisbane, Queensland, Australia. Lady Cilento Children's Hospital, 67568, South Brisbane, Queensland, Australia. University of Queensland, 1974, Northside Clinical Faculty, Brisbane, Queensland, Australia. Critical Care Research Group, Brisbane, Queensland, Australia. Hospital Universiti Sains Malaysia, 69847, Kota Bahru, Kelantan, Malaysia. The Canberra Hospital, Intensive Care Unit, Woden (Canberra) , Australian Capital Territory, Australia. Nambour General Hospital, Critical Care Medicine, Nambour, Queensland, Australia. Royal Brisbane and Women's Hospital, 3883, Emergency department, Herston, Queensland, Australia. Australian Red Cross Blood Service, Research and Development, Brisbane, Queensland, Australia. Imperial College, London, United Kingdom of Great Britain and Northern Ireland. University of Queensland, Critical Care Research Group, Brisbane, Queensland, Australia.Unintended Consequences; Fluid Resuscitation Worsens Shock in an Ovine Model of EndotoxemiaAm J Respir Crit Care MedAm J Respir Crit Care MedAmerican journal of respiratory and critical care medicineendotoxemiaresuscitationsepsisshock2018Jun 81535-4970 (Electronic) 1073-449X (Linking)29882682https://www.ncbi.nlm.nih.gov/pubmed/2988268210.1164/rccm.201801-0064OCByrne201853053053017Byrne, L.Obonyo, N. G.Diab, S.Dunster, K.Passmore, M.Boon, A. C.Hoe, L. S.Hay, K.Van Haren, F.Tung, J. P.Cullen, L.Shekar, K.Maitland, K.Fraser, J. F.The Critical Care Research Group, Chermside, Brisbane, Australia. Australian National University, Canberra, ACT, Australia. The Canberra Hospital Yamba Dr, Garran, ACT, Australia. Queensland University of Technology, Brisbane City, Australia. University of Queensland, St Lucia, Australia. 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Medical Research Council Clinical Trials Unit (MRC CTU) at UCL, 125 Aviation House, Kingsway, London, WC2B 6NH, UK. Department of Paediatrics, Mulago Hospital, Makerere College of Health Sciences, PO Box 7072, Kampala, Uganda. Department of Paediatrics, Mbale Regional Referral Hospital, Pallisa Road, PO Box 291, Mbale, Uganda. Mbale Clinical Research Institute (MCRI), Plot 29-33 Pallisa Rd, PO Box 1966, Mbale, Uganda. Department of Paediatrics, Soroti Regional Referral Hospital, PO Box 289, Soroti, Uganda. Kilifi Clinical Trials Facility, KEMRI-Wellcome Trust Research Programme, PO Box 203, Nairobi, Kenya. St Mary's Hospital, Lacor, PO Box 180, Gulu, Uganda. Teule Hospital, PO Box 81, Muheza, Tanzania. Kilifi Clinical Trials Facility, KEMRI-Wellcome Trust Research Programme, PO Box 203, Nairobi, Kenya. k.maitland@imperial.ac.uk. 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Faculty of Medicine, Imperial College, London, United Kingdom.High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern UgandaClin Infect DisClin Infect DisClinical infectious diseases : an official publication of the Infectious Diseases Society of America939-946647Age FactorsBiomarkersBlackwater Fever/complications/*diagnosis/*epidemiology/parasitologyChild, PreschoolErythrocytes/metabolism/parasitologyFemaleGlucosephosphate Dehydrogenase/geneticsHemoglobinopathies/complications/geneticsHumansInfantMaleMutationPatient Outcome AssessmentPhenotypePolymorphism, GeneticPrevalenceSeverity of Illness IndexSymptom AssessmentUganda/epidemiologyUrinalysisAfrican childblackwater feverhaemoglobinopathieshemoglobinuriamalaria2017Apr 11537-6591 (Electronic) 1058-4838 (Linking)28362936https://www.ncbi.nlm.nih.gov/pubmed/28362936PMC584822910.1093/cid/cix003Obonyo201747847847817Obonyo, N.Brent, B.Olupot-Olupot, P.Boele van Hensbroek, M.Kuipers, I.Wong, S.Shiino, K.Chan, J.Fraser, J.van Woensel, J. 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Wellcome Trust Centre for Clinical Tropical Medicine and Department of Paediatrics, Faculty of Medicine, Imperial College, London, W2 1PG, UK. k.maitland@imperial.ac.uk.Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study)Crit CareCrit Care103211AfricanChildrenEchocardiographyFluid resuscitationGastroenteritisHypovolaemic shockMortalityMyocardial functionRingers lactateSevere malnutrition2017May 31466-609X (Electronic) 1364-8535 (Linking)28468633https://www.ncbi.nlm.nih.gov/pubmed/28468633PMC541574710.1186/s13054-017-1679-0Mehta201747047047017Mehta, S.Burns, K. E. A.Machado, F. R.Fox-Robichaud, A. E.Cook, D. J.Calfee, C. S.Ware, L. B.Burnham, E. L.Kissoon, N.Marshall, J. C.Mancebo, J.Finfer, S.Hartog, C.Reinhart, K.Maitland, K.Stapleton, R. D.Kwizera, A.Amin, P.Abroug, F.Smith, O.Laake, J. H.Shrestha, G. S.Herridge, M. S.1 Department of Medicine. 2 Interdepartmental Division of Critical Care Medicine. 3 Sinai Health System. 4 Canadian Critical Care Society, Markham, Ontario, Canada. 5 Interdepartmental Division of Critical Care Medicine and. 6 Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada. 7 Anesthesiology, Pain, and Intensive Care Department, Federal University of Sao Paulo, Sao Paulo, Brazil. 8 Hamilton Health Sciences, Thrombosis and Atherosclerosis Research Institute. 9 Department of Medicine. 10 Clinical Epidemiology and Biostatistics, and. 11 Critical Care Medicine, McMaster University, Hamilton, Ontario, Canada. 12 Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine and. 13 Cardiovascular Research Institute, University of California, San Francisco, California. 14 Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee. 15 Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado. 16 Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. 17 Department of Surgery, St. Michael's Hospital, Toronto, Ontario, Canada. 18 University of Montreal Hospital Center and. 19 Division of Intensive Care, University of Montreal, Montreal, Quebec, Canada. 20 Division of Critical Care and Trauma, The George Institute for Global Health, Sydney, Australia. 21 University of Sydney, Sydney, Australia. 22 Department of Anesthesiology and Intensive Care, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany. 23 Global Sepsis Alliance, Jena, Germany. 24 Wellcome Trust Centre for Clinical Tropical Medicine, Department of Paediatrics, Imperial College London, London, United Kingdom. 25 Division of Pulmonary and Critical Care Medicine, University of Vermont, Burlington, Vermont. 26 Department of Anesthesia and Critical Care, Makerere University, Kampala, Uganda. 27 Department of Critical Care Medicine, Bombay Hospital Institute of Medical Sciences, Mumbai, India. 28 Centre Hospitalo-Universitaire Fattouma Bourguiba, Monastir, Tunisia. 29 Lawrence S. Bloomberg Faculty of Nursing, and. 30 Scandinavian Society of Anaesthesiology and Intensive Care Medicine. 31 Department of Anaesthesiology, Oslo University Hospital, Oslo, Norway; and. 32 Department of Anaesthesiology, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal. 33 University Health Network, University of Toronto, Toronto, Ontario, Canada.Gender Parity in Critical Care MedicineAm J Respir Crit Care MedAm J Respir Crit Care MedAmerican journal of respiratory and critical care medicine425-4291964*Critical CareFemaleHumans*Interprofessional RelationsMale*Practice Guidelines as TopicSex DistributionSexism/*prevention & controlcritical carediversitygenderinterprofessional2017Aug 151535-4970 (Electronic) 1073-449X (Linking)28240961https://www.ncbi.nlm.nih.gov/pubmed/2824096110.1164/rccm.201701-0076CPMaitland201750350350317Maitland, K.Kiguli, S.Opoka, R. O.Olupot-Olupot, P.Engoru, C.Njuguna, P.Bandika, V.Mpoya, A.Bush, A.Williams, T. 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A pilot rehydration study for severe dehydration: WHO plan C versus slower rehydrationWellcome Open ResWellcome Open Res62262WHOacute gastroenteritischildrendehydrationintravenous fluids201710th August 20172398-502X (Print) 2398-502X (Linking)28905004https://www.ncbi.nlm.nih.gov/pubmed/28905004PMC557188810.12688/wellcomeopenres.12261.1Houston201752452452417Houston, K. A.Gibb, J. G.Maitland, K.Department of Paediatrics, Faculty of Medicine, Imperial College, London, W2 1PG, UK. KEMRI-Wellcome Trust Research Programme, Kilifi, 80108, Kenya.Oral rehydration of malnourished children with diarrhoea and dehydration: A systematic reviewWellcome Open ResWellcome Open Res662*Africa*Asia*dehydration*gastroenteritis*malnutrition*oral rehydration solution*rehydration*systematic review201718th August 20172398-502X (Print) 2398-502X (Linking)29090271https://www.ncbi.nlm.nih.gov/pubmed/29090271PMC565721910.12688/wellcomeopenres.12357.3Houston201748748748717Houston, K. A.Gibb, J. G.Maitland, K.Department of Paediatrics, Faculty of Medicine, Imperial College, London, W2 1PG, UK. KEMRI-Wellcome Trust Research Programme, Kilifi, 80108, Kenya.Intravenous rehydration of malnourished children with acute gastroenteritis and severe dehydration: A systematic reviewWellcome Open ResWellcome Open Res65265AfricaAsiadehydrationgastroenteritismalnutritionrehydrationsystematic review201718th August 20172398-502X (Print) 2398-502X (Linking)28944301https://www.ncbi.nlm.nih.gov/pubmed/28944301PMC559008210.12688/wellcomeopenres.12346.1Hakim201769069069017Hakim, J.Musiime, V.Szubert, A. J.Mallewa, J.Siika, A.Agutu, C.Walker, S.Pett, S. L.Bwakura-Dangarembizi, M.Lugemwa, A.Kaunda, S.Karoney, M.Musoro, G.Kabahenda, S.Nathoo, K.Maitland, K.Griffiths, A.Thomason, M. J.Kityo, C.Mugyenyi, P.Prendergast, A. J.Walker, A. S.Gibb, D. M.Reality Trial TeamFrom the University of Zimbabwe Clinical Research Center, Harare, Zimbabwe (J.H., M.B.-D., G.M., K.N.); Joint Clinical Research Center, Kampala (V.M., C.K., P.M.), Mbarara (A.L.), and Fort Portal (S. Kabahenda) - all in Uganda; Medical Research Council Clinical Trials Unit at University College London (A.J.S., S.L.P., A.G., M.J.T., A.S.W., D.M.G.), Wellcome Trust Centre for Clinical Tropical Medicine and Department of Paediatrics, Imperial College (K.M.), and Queen Mary University of London (A.J.P.), London, and the Centre for Health Economics, University of York, York (S.W.) - all in the United Kingdom; the Department of Medicine and Malawi-Liverpool-Wellcome Trust Clinical Research Program, Blantyre, Malawi (J.M., S. Kaunda); and Moi University School of Medicine, Eldoret (A.S., M.K.), and the Kenya Medical Research Institute (KEMRI) Wellcome Trust Research Program, Kilifi (C.A., K.M.) - both in Kenya.Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in AfricaN Engl J MedN Engl J MedThe New England journal of medicine233-24537732017/07/21AIDS-Related Opportunistic Infections/*prevention & controlAdolescentAdultAfrica South of the Sahara/epidemiologyAgedAnti-Infective Agents/adverse effects/*therapeutic useAnti-Retroviral Agents/adverse effects/*therapeutic useCD4 Lymphocyte CountChildDrug Therapy, CombinationFemaleHIV Infections/*drug therapy/mortalityHumansIsoniazid/therapeutic useKaplan-Meier EstimateMaleMiddle AgedPyridoxine/therapeutic useTrimethoprim, Sulfamethoxazole Drug Combination/therapeutic useYoung Adult2017Jul 201533-4406 (Electronic) 0028-4793 (Linking)28723333https://www.ncbi.nlm.nih.gov/pubmed/28723333PMC560326910.1056/NEJMoa1615822Obonyo201647147147117Obonyo, N. 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School of Medicine, University of Queensland, Brisbane, Queensland, Australia. fraserjohn001@gmail.com.Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic reviewIntensive Care Med ExpIntensive Care Med Exp3841Fluid resuscitationIntravital fluorescence microscopyLaser Doppler flowmetryLaser speckle imagingLipopolysaccharideMicrocirculationOxygen extractionSepsisSeptic shockSidestream dark-field videomicroscopy2016Dec2197-425X (Linking)27873263https://www.ncbi.nlm.nih.gov/pubmed/27873263PMC511837710.1186/s40635-016-0112-3Nightingale201646646646617Nightingale, H.Walsh, K. J.Olupot-Olupot, P.Engoru, C.Ssenyondo, T.Nteziyaremye, J.Amorut, D.Nakuya, M.Arimi, M.Frost, G.Maitland, K.Faculty of Medicine, Nutrition and Dietetic Research Group, Division of Diabetes, Endocrinology and Metabolism, Department of Investigative Medicine, Imperial College London, Hammersmith Campus, London W12 0NN, UK. Busitema University Faculty of Health Sciences (BUFHS), Mbale Campus, Uganda; Mbale Regional Referral Hospital Clinical Research Unit (MCRU), Mbale, Uganda. Department of Paediatrics, Soroti Regional Referral Hospital, Soroti, Uganda. Mbale Regional Referral Hospital Clinical Research Unit (MCRU), Mbale, Uganda. Kilifi Clinical Trials Facility, KEMRI-Wellcome Trust Research Programme, PO Box 230, Kilifi, Kenya; Wellcome Trust Centre for Clinical Tropical Medicine, and Department of Paediatrics, Faculty of Medicine, Imperial College, London, W2 1PG, UK.Validation of triple pass 24-hour dietary recall in Ugandan children by simultaneous weighed food assessmentBMC NutrBMC Nutr2Ugandachildrendietary assessmentportion size estimationundernutritionvalidation2016Aug 242055-0928 (Linking)27795836https://www.ncbi.nlm.nih.gov/pubmed/27795836PMC508109310.1186/s40795-016-0092-4Nabwera201646446446417Nabwera, H. M.Fegan, G.Shavadia, J.Denje, D.Mandaliya, K.Bates, I.Maitland, K.Hassall, O. W.Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya. hnabwera@doctors.org.uk. Liverpool School of Tropical Medicine, Liverpool, UK. hnabwera@doctors.org.uk. Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya. Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK. Swansea Trials Unit, Swansea University Medical School, Swansea, UK. The Aga Khan University Hospital, Nairobi, Kenya. Coast Provincial General Hospital, Mombasa, Kenya. Regional Blood Transfusion Centre, Mombasa, Kenya. Liverpool School of Tropical Medicine, Liverpool, UK. Department of Medicine, Imperial College, London, UK. Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.Pediatric blood transfusion practices at a regional referral hospital in KenyaTransfusionTransfusionTransfusion2016Sep 091537-2995 (Electronic) 0041-1132 (Linking)27611471https://www.ncbi.nlm.nih.gov/pubmed/27611471PMC511158810.1111/trf.13774Maitland201646546546517Maitland, K.From the Wellcome Centre for Clinical Tropical Medicine, Imperial College, London.SevD|��D���������������������������������������������������������������ere Malaria in African Children - The Need for Continuing InvestmentN Engl J MedN Engl J MedThe New England journal of medicine2416-241737525Africa South of the Sahara/epidemiologyAntimalarials/therapeutic useArtemisinins/therapeutic useChild*Clinical Trials as TopicFluid Therapy/adverse effectsHumansMalaria/mortality/*therapy2016Dec 221533-4406 (Electronic) 0028-4793 (Linking)28002698https://www.ncbi.nlm.nih.gov/pubmed/2800269810.1056/NEJMp1613528Church201646246246217Church, J. A.Nyamako, L.Olupot-Olupot, P.Maitland, K.Urban, B. C.Centre for Paediatrics, Blizard Institute, Queen Mary University of London, London, UK. j.church@qmul.ac.uk. KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. j.church@qmul.ac.uk. KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. LNyamako@kemri-wellcome.org. Mbale Regional Referral Hospital Clinical Research Unit (MCRU), Mbale, Uganda. polupotolupot@yahoo.com. Busitema University Faculty of Health Sciences, Mbale Campus, Mbale, Uganda. polupotolupot@yahoo.com. KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. k.maitland@imperial.ac.uk. Wellcome Centre for Clinical Tropical Medicine, Imperial College, London, UK. k.maitland@imperial.ac.uk. KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. britta.urban@lstmed.ac.uk. Parasitology Department, Liverpool School of Tropical Medicine, Liverpool, UK. britta.urban@lstmed.ac.uk.Increased adhesion of Plasmodium falciparum infected erythrocytes to ICAM-1 in children with acute intestinal injuryMalar JMalar JMalaria journal5415120161475-2875 (Electronic) 1475-2875 (Linking)26830671http://www.ncbi.nlm.nih.gov/pubmed/26830671PMC473623610.1186/s12936-016-1110-3Mpoya201545845845817Mpoya, A.Kiguli, S.Olupot-Olupot, P.Opoka, R. O.Engoru, C.Mallewa, M.Chimalizeni, Y.Kennedy, N.Kyeyune, D.Wabwire, B.M'Baya, B.Bates, I.Urban, B.von Hensbroek, M. B.Heyderman, R.Thomason, M. J.Uyoga, S.Williams, T. N.Gibb, D. M.George, E. C.Walker, A. S.Maitland, K.KEMRI-Wellcome Trust Research Programme, PO Box 230, Kilifi, Kenya. AMpoya@kemri-wellcome.org. Department of Paediatrics, Mulago Hospital, Makerere University, PO Box 7072, Kampala, Uganda. skwalube@yahoo.co.uk. Department of Paediatrics, Mbale Regional Referral Hospital Pallisa Road Zone, PO Box 921, Mbale, Uganda. polupotolupot@yahoo.com. Department of Paediatrics, Mulago Hospital, Makerere University, PO Box 7072, Kampala, Uganda. opokabob@yahoo.com. Department of Paediatrics, Soroti Regional Referral Hospital, PO Box 289, Soroti, Uganda. charlesengoru@yahoo.co.uk. College of Medicine, Department of Paediatrics and Child Health, University of Malawi, P/Bag 360, Chichiri, Blantyre 3, Malawi. mmallewa@mlw.medcol.mw. College of Medicine, Department of Paediatrics and Child Health, University of Malawi, P/Bag 360, Chichiri, Blantyre 3, Malawi. gaveta3@yahoo.com. College of Medicine, Department of Paediatrics and Child Health, University of Malawi, P/Bag 360, Chichiri, Blantyre 3, Malawi. nkennedy@medcol.mw. Uganda Blood Transfusion Service, PO Box 1772, Kampala, Uganda. kyeyunedorothy@yahoo.com. Mbale Regional Blood Bank, PO Box 284, Mbale, Uganda. benjaminwabwire@yahoo.com. Malawi Blood Transfusion Service, PO Box 2681, Blantyre, Malawi. mbayab@yahoo.com. Malawi-Liverpool-Wellcome Trust Clinical Research Programme, PO Box 30096, Chichiri, Blantyre 3, Malawi. Imelda.Bates@lstmed.ac.uk. Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. Imelda.Bates@lstmed.ac.uk. Malawi-Liverpool-Wellcome Trust Clinical Research Programme, PO Box 30096, Chichiri, Blantyre 3, Malawi. Britta.Urban@lstmed.ac.uk. Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. Britta.Urban@lstmed.ac.uk. Global Child Health Group, Emma Children's Hospital Academic Medical Centre, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands. m.boele@amc.uva.nl. Malawi-Liverpool-Wellcome Trust Clinical Research Programme, PO Box 30096, Chichiri, Blantyre 3, Malawi. r.heyderman@ucl.ac.uk. Division of Infection and Immunity, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK. r.heyderman@ucl.ac.uk. 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R.Mortality among Kenyan children admitted to a rural district hospital on weekends as compared with weekdaysPediatricsPediatricsPediatricsPediatricsPediatricsPediatrics1737-8; author reply 173811462004/12/03Child*Hospital MortalityHospitals, RuralHumansKenyaPatient AdmissionPrognosisTime Factors2004Dec1098-4275 (Electronic) 0031-4005 (Linking)15574646Comment Letterhttp://www.ncbi.nlm.nih.gov/pubmed/1557464610.1542/peds.2004-1263engMaitland200393939317Maitland, K.Pamba, A.Newton, C. R.Levin, M.Centre for Geographic Medicine Research-Coast, Kenya Medical Research Institute, Kilifi, Kenya.Response to volume resuscitation in children with severe malariaPediatr Crit Care MedPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care SocietiesPediatr Crit Care MedPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care SocietiesPediatr Crit Care MedPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies426-31442003/10/04Acidosis/*complications/physiopathology/therapyChild, PreschoolHemodynamics/physiologyHumansHypovolemia/*etiology/physiopathology/*therapyInfantMalaria, Falciparum/*complications/physiopathology/*therapyMonitoring, PhysiologicPlasma Substitutes/*therapeutic useProspective StudiesSeverity of Illness Index2003Oct1529-7535 (Print) 1529-7535 (Linking)14525636Clinical Trial Clinical Trial, Phase I Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/1452563610.1097/01.PCC.0000090293.32810.4EengMaitland200395959517Maitland, K.Levin, M.English, M.Mithwani, S.Peshu, N.Marsh, K.Newton, C. R.Centre for Geographic Medicine Research, Coast, KEMRI/Wellcome Trust Unit, P.O. Box 230, Kilifi, Kenya. kmaitland@kilifi.mimcom.netSevere P. falciparum malaria in Kenyan children: evidence for hypovolaemiaQJMQJM : monthly journal of the Association of PhysiciansQJMQJM : monthly journal of the Association of PhysiciansQJMQJM : monthly journal of the Association of Physicians427-349662003/06/06Acidosis/*drug therapy/*etiologyBlood Transfusion/methodsChildChild, PreschoolFemaleFluid Therapy/methodsHumansHypovolemia/*complications/*drug therapyInfantInfant, NewbornKenya/epidemiologyMalaria, Falciparum/*complications/mortalityMaleRetrospective StudiesSurvival Rate2003Jun1460-2725 (Print) 1460-2393 (Linking)12788961Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/12788961engMaitland200394949417Maitland, K.Bejon, P.Newton, C. R.The Centre for Geographic Medicine Research, Coast, KEMRI, Kilifi, Kenya. kmaitland@kilifi.mimcom.netMalariaCurr Opin Infect DisCurrent opinion in infectious diseasesCurr Opin Infect DisCurrent opinion in infectious diseasesCurr Opin Infect DisCurrent opinion in infectious diseases389-951652003/09/23Acidosis/complications/prevention & controlAntimalarials/therapeutic useClinical Trials as TopicHumansMalaria/complications/*epidemiology/*prevention & controlMalaria VaccinesWorld Health2003Oct0951-7375 (Print) 0951-7375 (Linking)14501990Reviewhttp://www.ncbi.nlm.nih.gov/pubmed/1450199010.1097/01.qco.0000092809.64370.b3engGoodman200396969617Goodman, A.Williams, T. N.Maitland, K.Department of Paediatrics, St. Mary's Hospital, Imperial College, London, United Kingdom.Ciguatera poisoning in VanuatuAm J Trop Med HygThe American journal of tropical medicine and hygieneAm J Trop Med HygThe American journal of tropical medicine and hygieneAm J Trop Med HygThe American journal of tropical medicine and hygiene263-66822003/03/19AdolescentAdultAge DistributionAgedAnimalsChildChild, PreschoolCiguatera Poisoning/*epidemiology/etiologyFemale*FishesHumansInfantInfant, NewbornMaleMedical RecordsMiddle AgedPacific Islands/epidemiologyRetrospective StudiesSeasonsSex Factors2003Feb0002-9637 (Print) 0002-9637 (Linking)12641423Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/12641423engMaitland200010110110117Maitland, K.Kyes, S.Williams, T. N.Newbold, C. I.Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK. kmaitland@hammer.imm.ox.ac.ukGenetic restriction of Plasmodium falciparum in an area of stable transmission: an example of island evolution?ParasitologyParasitologyParasitologyParasitologyParasitologyParasitology335-43120 ( Pt 4)2000/05/16AdolescentAdultAllelesAnimalsAntigens, Protozoan/*geneticsAntigens, Surface/*geneticsChildChild, PreschoolGenetic VariationGenotypeHumansMalaria, Falciparum/*genetics/*transmissionMerozoite Surface Protein 1/*geneticsMiddle AgedPlasmodium falciparum/*geneticsPolymorphism, GeneticProtozoan Proteins/*geneticsVanuatu2000Apr0031-1820 (Print) 0031-1820 (Linking)10811274Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/10811274engMaitland200010010010017Maitland, K.Temporal association of chickenpox and meningococcal disease in children: a report of three casesActa PaediatrActa Paediatr744-58962000/07/29Chickenpox/*complicationsFemaleHumansImmunocompromised HostInfantMaleMeningococcal Infections/*etiologyRisk Factors2000Jun0803-5253 (Print) 0803-5253 (Linking)10914977Case Reports Letterhttp://www.ncbi.nlm.nih.gov/pubmed/10914977engWilliams199910210210217Williams, T. N.Maitland, K.Rees, D. C.Peto, T. E.Bowden, D. K.Weatherall, D. J.Clegg, J. B.Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom.Reduced soluble transferrin receptor concentrations in acute malaria in VanuatuAm J Trop Med HygThe American journal of tropical medicine and hygieneAm J Trop Med HygThe American journal of tropical medicine and hygieneAm J Trop Med HygThe American journal of tropical medicine and hygiene875-86051999/05/27AdolescentAdultAnemia/*diagnosis/etiologyChildChild, PreschoolFemaleFerritins/bloodHumansInfantInfant, NewbornMalaria, Falciparum/*blood/complicationsMalaria, Vivax/*blood/complicationsMaleReceptors, Transferrin/*bloodSolubilityVanuatu1999May0002-9637 (Print) 0002-9637 (Linking)10344669Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/10344669engWilliams199910310310317Williams, T. N.Maitland, K.Molecular Parasitology Group Institute of Molecular Medicine John Radcliffe Hospital, Oxford, UK OX3 9DS.Reply from williams and maitlandParasitol TodayParasitol Today167-81541999/05/141999Apr0169-4758 (Print) 0169-4758 (Linking)10323752http://www.ncbi.nlm.nih.gov/pubmed/10323752EngWilliams199810710710717Williams, T. N.Maitland, K.Martin, P. M.Weatherall, D. J.Clegg, J. B.Splenic size in homozygous alpha+ thalassaemiaBr J HaematolBritish journal of haematologyBr J HaematolBritish journal of haematologyBr J HaematolBritish journal of haematology611-210031998/03/21ChildHomozygoteHumansSpleen/pathologySplenomegaly/*pathologyalpha-Thalassemia/*pathology1998Mar0007-1048 (Print) 0007-1048 (Linking)9504656Letter Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/9504656engRees199810410410417Rees, D. C.Williams, T. N.Maitland, K.Clegg, J. B.Weatherall, D. J.MRC Molecular Haematology Unit, Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital.Alpha thalassaemia is associated with increased soluble transferrin receptor levelsBr J HaematolBritish journal of haematologyBr J HaematolBritish journal of haematologyBr J HaematolBritish journal of haematology365-910321998/11/25AdolescentAdultAge FactorsChildChild, PreschoolErythropoiesisFemaleFerritins/bloodGenotypeGlobins/geneticsHumansInfantInfant, NewbornMaleReceptors, Transferrin/*bloodSex FactorsSolubilityalpha-Thalassemia/*blood/genetics1998Nov0007-1048 (Print) 0007-1048 (Linking)9827906Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/9827906engMaitland199812712712717Maitland, K.Williams, T. N.Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK OX3 9DS.Malaria mortality: the pacific enigmaParasitol TodayParasitol Today258-91472006/10/171998Jul0169-4758 (Print) 0169-4758 (Linking)17040778http://www.ncbi.nlm.nih.gov/pubmed/17040778engMaitland199854545417Maitland, K.Williams, T.Institute of Molecular Medicine, John Radcliffe Hospital, Oxford UK OX1 3PS.ReplyParasitol TodayParasitol Today2931472006/10/171998Jul0169-4758 (Print) 0169-4758 (Linking)17040788http://www.ncbi.nlm.nih.gov/pubmed/17040788engBarnardo199810510510517Barnardo, M. C.Welsh, K. I.Vilches, C.Maitland, K.Bunce, M.Transplantation Immunology, Oxford Transplant Centre, Churchill Hospital, United Kingdom. mbarnard@hgmp.mrc.ac.ukAllele-specific HLA-B*15 typing by PCR-SSP and its application to four distinct ethnic populationsTissue AntigensTissue antigensTissue AntigensTissue antigensTissue AntigensTissue antigens293-3005131998/04/29*AllelesDNA PrimersEthnic Groups/*geneticsHLA-B Antigens/*geneticsHLA-B15 AntigenHistocompatibility TestingHumansPolymerase Chain Reaction/*methods1998Mar0001-2815 (Print) 0001-2815 (Linking)9550331Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/9550331engWilliams199710610610617Williams, T. N.Maitland, K.Phelps, L.Bennett, S.Peto, T. E.Viji, J.Timothy, R.Clegg, J. B.Weatherall, D. J.Bowden, D. K.Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK. tom.williams@imm.ox.ac.ukPlasmodium vivax: a cause of malnutrition in young childrenQJMQJM : monthly journal of the Association of PhysiciansQJMQJM : monthly journal of the Association of PhysiciansQJMQJM : monthly journal of the Association of Physicians751-790121998/04/16Age FactorsAnthropometryBody WeightChildChild, PreschoolCohort StudiesFemaleHumansInfantLogistic ModelsMalaria, Falciparum/complicationsMalaria, Vivax/*complicationsMaleMelanesiaNutrition Disorders/*etiologyRisk Factorschildren under 10 years of age living in 13 villages in the island of EspirituSanto, Vanuatu, where malaria is endemic. 18% of children under 5 years wereunderweight, 5% were wasted, and 20% were stunted. The mean weight-for-age Zscore for the 1114 children resident in hyperendemic villages was significantlylower (-0.99) than that of the 397 children living in the mesoendemic area(-0.77). According to multiple logistic regression analysis, the only factorssignificantly associated with wasting in the hyperendemic area were age under 5years (odds ratio (OR), 1.895% confidence interval (CI), 1.2-2.9) and 1 or moreepisodes of clinical Plasmodium vivax malaria in the 6 months precedingnutritional assessment (OR, 2.495% CI, 1.3-4.4). Only male sex and low birthweight were significantly associated with stunting. The incidence of P. vivaxinfection in the 6 months preceding the survey was significantly higher inunderweight compared to non-underweight children (relative risk (RR), 2.695%CI, 1.5-4.4). The incidence of P. falciparum malaria was not significantlydifferent between groups, suggesting that this is not a major cause ofmalnutrition on the island. Wasting neither predisposed to nor protected againstmalaria of either species. Although P. vivax malaria is generally regarded asbenign, it may produce substantial global mortality through malnutrition.1997Dec1460-2725 (Print) 1460-2393 (Linking)9536339Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/9536339engMaitland199710810810817Maitland, K.Williams, T. N.Peto, T. E.Day, K. P.Clegg, J. B.Weatherall, D. J.Bowden, D. K.Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.Absence of malaria-specific mortality in children in an area of hyperendemic malariaTrans R Soc Trop Med HygTransactions of the Royal Society of Tropical Medicine and HygieneTrans R Soc Trop Med HygTransactions of the Royal Society of Tropical Medicine and HygieneTrans R Soc Trop Med HygTransactions of the Royal Society of Tropical Medicine and Hygiene562-69151998/02/17AdolescentAdultAgedChildChild, PreschoolCohort StudiesCross-Sectional Studies*Endemic DiseasesFemaleFollow-Up StudiesHumansIncidenceInfantInfant, NewbornMalaria, Falciparum/*epidemiology/mortalityMalaria, Vivax/*epidemiology/mortalityMaleMiddle AgedPrevalenceProspective StudiesVanuatu/epidemiology1997Sep-Oct0035-9203 (Print) 0035-9203 (Linking)9463668Case Reports Research Support, Non-U.S. Gov'thttps://www.ncbi.nlm.nih.gov/pubmed/9463668engMaitland199711011011017Maitland, K.Williams, T. N.Newbold, C. I.Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK. kmaitland@immads2.jr2.ox.ac.ukPlasmodium vIvax and P. falciparum: Biological interactions and the possibility of cross-species immunityParasitol TodayParasitology todayParasitol Today227-311361997/06/011997Jun0169-4758 (Print) 0169-4758 (Linking)15275075http://www.ncbi.nlm.nih.gov/pubmed/15275075engMaitland199710910910917Maitland, K.Williams, T. N.Kotecka, B. M.Edstein, M. D.Rieckmann, K. H.Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.Plasma chloroquine concentrations in young and older malaria patients treated with chloroquineActa TropActa tropicaActa TropActa tropicaActa TropActa tropica155-616631997/09/10AdolescentAdultAntimalarials/*bloodChildChild, PreschoolChloroquine/*blood/therapeutic useDrug ResistanceHumansInfantInfant, NewbornMiddle Aged1997Sep 100001-706X (Print) 0001-706X (Linking)9210966Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/9210966engWilliams199611211211217Williams, T. N.Maitland, K.Ganczakowski, M.Peto, T. E.Clegg, J. B.Weatherall, D. J.Bowden, D. K.Institute of Molecular Medicine, John Radcliffe Hospital, Oxford.Red blood cell phenotypes in the alpha + thalassaemias from early childhood to maturityBr J HaematolBritish journal of haematologyBr J HaematolBritish journal of haematologyBr J HaematolBritish journal of haematology266-729521996/11/01AdolescentAdultAgedAged, 80 and over*Blood CellsChildChild, PreschoolErythrocyte CountFemaleGene DeletionHemoglobins/analysisHeterozygoteHomozygoteHumansMaleMiddle AgedPhenotypealpha-Thalassemia/*blood/genetics1996Nov0007-1048 (Print) 0007-1048 (Linking)8904880Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/8904880engWilliams199611311311317Williams, T. N.Maitland, K.Bennett, S.Ganczakowski, M.Peto, T. E.Newbold, C. I.Bowden, D. K.Weatherall, D. J.Clegg, J. B.Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.High incidence of malaria in alpha-thalassaemic childrenNatureNatureNatureNatureNatureNature522-538366001996/10/10AnimalsChildChild, PreschoolCohort StudiesGenetic Predisposition to DiseaseHeterozygoteHomozygoteHumansImmunityIncidenceInfantInfant, NewbornMalaria/*complications/*epidemiology/immunologyMalaria, Falciparum/*complications/epidemiology/immunologyMalaria, Vivax/immunologyPlasmodium vivaxPrevalenceProspective StudiesSelection, GeneticSplenomegaly/epidemiology/etiologyVanuatu/epidemiologyalpha-Thalassemia/*complications/epidemiology/genetics1996Oct 100028-0836 (Print) 0028-0836 (Linking)8849722Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/884972210.1038/383522a0engMaitland199611111111117Maitland, K.Williams, T. N.Bennett, S.Newbold, C. I.Peto, T. E.Viji, J.Timothy, R.Clegg, J. B.Weatherall, D. J.Bowden, D. K.Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.The interaction between Plasmodium falciparum and P. vivax in children on Espiritu Santo island, VanuatuTrans R Soc Trop Med HygTransactions of the Royal Society of Tropical Medicine and HygieneTrans R Soc Trop Med HygTransactions of the Royal Society of Tropical Medicine and HygieneTrans R Soc Trop Med HygTransactions of the Royal Society of Tropical Medicine and Hygiene614-209061996/11/01AnimalsAnopheles/classificationChildChild, PreschoolCohort StudiesCross-Sectional StudiesFemaleFever/complications/epidemiologyHemoglobins/analysisHumansIncidenceInfantInfant, NewbornLogistic ModelsLongitudinal StudiesMalaria, Falciparum/complications/*epidemiologyMalaria, Vivax/complications/*epidemiologyMaleMorbidityParasitemia/epidemiologyPrevalenceSeasonsSplenomegaly/complicationsVanuatu/epidemiology1996Nov-Dec0035-9203 (Print) 0035-9203 (Linking)9015495Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/9015495engBryan199611411411417Bryan, J. H.Burwell, C.Maitland, K.Williams, T.Tropical Health Program and Department of Entomology, University of Queensland, Australia.Culicine mosquitoes (Diptera: Culicidae) attracted to humans on Espiritu Santo, VanuatuMed Vet EntomolMedical and veterinary entomologyMed Vet EntomolMedical and veterinary entomologyMed Vet EntomolMedical and veterinary entomology101-21011996/01/01Aedes/*classificationAnimalsCulex/*classificationCulicidaeHumansVanuatu1996Jan0269-283X (Print) 0269-283X (Linking)8834750http://www.ncbi.nlm.nih.gov/pubmed/8834750engWilliams199511611611617Williams, T. N.Maitland, K.Foley, D. H.Northern District Hospital, Espiritu Santo, Vanuatu.Malaria sporozoite rates for Anopheles farauti s.s. Laveran (Diptera: culicidae) from VanuatuAnn Trop Med ParasitolAnnals of tropical medicine and parasitologyAnn Trop Med ParasitolAnnals of tropical medicine and parasitologyAnn Trop Med ParasitolAnnals of tropical medicine and parasitology305-78931995/06/01AnimalsAnopheles/*parasitologyPlasmodium falciparum/*isolation & purificationVanuatu1995Jun0003-4983 (Print) 0003-4983 (Linking)7668922Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/7668922engGanczakowski199511711711717Ganczakowski, M.Bowden, D. K.Maitland, K.Williams, T. N.O'Shaughnessy, D.Viji, J.Lucassen, A.Clegg, J. B.Weatherall, D. J.Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, U.K.Thalassaemia in Vanuatu, south-west Pacific: frequency and haematological phenotypes of young childrenBr J HaematolBritish journal of haematologyBr J HaematolBritish journal of haematologyBr J HaematolBritish journal of haematology485-958931995/03/01Child, PreschoolCross-Sectional StudiesErythrocyte CountErythrocyte IndicesFollow-Up StudiesGene DeletionGenotypeGlobins/geneticsHemoglobins/metabolismHemoglobins, Abnormal/analysisHumansInfantInfant, NewbornMalaria/complicationsPhenotypeSpleen/pathologyVanuatu/epidemiologyalpha-Thalassemia/*blood/*epidemiology/genetics1995Mar0007-1048 (Print) 0007-1048 (Linking)7734345Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/7734345engBrindle199511511511517Brindle, P. M.Maitland, K.Williams, T. N.Ganczakowski, M. E.Faculty of Medicine, University of Bristol, UK.A survey for the rare blood group antigen variants, En(a-), Gerbich negative and Duffy negative on Espiritu Santo, Vanuatu in the South PacificHum HeredHuman heredityHum HeredHuman heredityHum HeredHuman heredity211-44541995/07/01African Continental Ancestry Group/*geneticsAntigenic VariationBlood Group Antigens/*geneticsBlood Grouping and CrossmatchingChildChild, PreschoolFemaleHumansInfantInfant, NewbornMalaria/bloodMalePregnancyVanuatu1995Jul-Aug0001-5652 (Print) 0001-5652 (Linking)7558053Research Support, Non-U.S. Gov'thttp://www.ncbi.nlm.nih.gov/pubmed/7558053engsDyK  _ENREF_18w666666666vvvvvvvvv66666>6666666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@_HmH nH sH tH @`@ ` NormalCJ_HaJmH sH tH l@l / Heading 1)$$ 7 @&^ `a$5>*CJOJQJ^J`@`  Heading 2$$ 7@&a$5>*CJOJQJ\^Jn@n  Heading 3,$$ 7[@&^`[a$5CJOJQJ\^JJ@J  Heading 4$@&5CJOJQJ\^J:@:  Heading 5$@&5\^@^  Heading 6$$dh@&^a$5CJOJQJ\^JB@B 6 Heading 7@&CJOJQJaJR@R  Heading 8$dh@&OJQJ^JaJmH sH DA`D Default Paragraph FontVi@V 0 Table Normal :V 44 la (k`( 0No List 8>@8 Title$a$ 5CJ aJJ@ Subtitleh$ S $d%d&d'd-DM NOPQa$5CJOJQJ^JaJXOX AchievementP%dOCJaJmH sH PB@"P  Body TextdhOJQJ\^JaJmH sH DP@2D  Body Text 25\aJmH sH hR@Bh Body Text Indent 2$dh*$^a$OJQJ^JaJLC@RL Body Text Indent *$^aJ`S@b` Body Text Indent 3`^``CJOJQJ^Jborb Default 7$8$H$-B*CJOJQJ^J_HaJmH phsH tH H@H {0 Balloon TextCJOJQJ^JaJV/V {0Balloon Text CharCJOJQJ^JaJmH sH ^o^ 4Q Hoofdtekst A)B*CJOJPJQJ_HmHphsHtH 6U`6 ]0 Hyperlink >*B*ph4 @4 Y^T0Footer  !6/6 Y^T0 Footer CharCJaJ.)`. 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