ࡱ> _aZ[\]^q` L3bjbjqPqP ::)V t t t t X ```XDX Q$L^nnnH_QaQaQaQaQaQaQ$ThlVQ "Qt t nncQ^ t 8n n_Q_Q^5  O?n `nY9`;h@LQ0Q_<WWO?O?W c?eR_TeeeQQg^eeeQX X X ıDX X X X X X t t t t t t   Aspects of Conscious/Sedation Analgesia Compiled by Terry Rudd, RN, MSN  INCLUDEPICTURE "http://bp0.blogger.com/_S2XAwLyKepY/R_aFqlbCkTI/AAAAAAAAAkQ/xXQJLWbJwmY/s320/versed.jpg" \* MERGEFORMATINET  4.0 Contact Hours California Board of Registered Nursing CEP#15122 Compiled by Terry Rudd RN, MSN, CCRN Key Medical Resources, Inc. 6896 Song Sparrow Rd, Corona, Ca 92880 951 520-3116 FAX: 951 739-0378 Disclaimer: This packet is intended to provide information and is not a substitute for any facility policies or procedures or in-class training. Legal information provided here is for information only and is not intended to provide legal advice. Each state or facility may have different training requirements or regulations. Participants who practice the techniques do so voluntarily. Information has been compiled from various internet sources as indicated at the end of the packet. Updated 9/2009 Title: Aspects of Conscious/Sedation Analgesia 4.0 C0NTACT HOURS CEP #15122 70% is Passing Score Please note that C.N.A.s cannot receive continuing education hours for home study. Key Medical Resources, Inc. 6896 Song Sparrow Rd., Corona, CA 92880 Please print or type all information. Complete answers and return answer sheet with evaluation form via fax or email to Key Medical Resources, Inc. Email:  HYPERLINK "mailto:Educate100@aol.com" Educate100@aol.com FAX: 951 739-0378 Name: ________________________________ Date Completed: ______________ Score____ Email:_____________________________ Cell Phone: ( ) ______________ Certificate will be emailed to you. Address: _________________________________ City: _________________ Zip: _______ License # & Type: (i.e. RN 555555) _________________Place of Employment: ____________ Please place your answers on this form. _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ _____ My Signature indicates that I have completed this module on my own._____________________ (Signature) EVALUATION FORM Poor Excellent 1. The content of this program was: 1 2 3 4 5 6 7 8 9 10 2. The program was easy to understand: 1 2 3 4 5 6 7 8 9 10 3. The objectives were clear: 1 2 3 4 5 6 7 8 9 10 4. This program applies to my work: 1 2 3 4 5 6 7 8 9 10 5. I learned something from this course: 1 2 3 4 5 6 7 8 9 10 6. Would you recommend this program to others? Yes No 7. The cost of this program was: High OK Low Other Comments: Title: Aspects of Conscious/Sedation Analgesia Self Study Exam 4.0 C0NTACT HOURS Choose the Single Best Answer for the Following Questions and Place Answers on Form: All of the following describe Sedation Analgesia except: Allows protective reflexes to be maintained A medically controlled state of depressed Consciousness or unconscious- ness from which the patient is not easily aroused and is unable to respond purposefully to physical stimulation or verbal command Retains the patient's ability to maintain a patent airway independently and continuously Permits appropriate response by the patient to physical stimulation or verbal command (e.g:open your eyes") The drugs, doses and techniques are not intended to produce a loss of consciousness. Moderate or Sedation Analgesia and general anesthesia are the same: True False A 55-year-old woman has a history of hypertension which is well controlled. She is scheduled for a colonoscopy. This patient is an ASA Physical Classification of ASA I ASA II ASA III ASA IV ASA V Prior to performing a procedure with Sedation Analgesia the physician must perform or provide the following: A brief medical history and physical exam A signed consent form An ASA Patient Classification Status Verify the patient's NPO status All of the above Patient assessment pre procedure includes: Level of consciousness. NPO status. Completion of a consent. All of the above. Which agent (usually preferred) used in Sedation Analgesia is a short acting benzodiazepine? Midazolam (Versed) Chloral Hydrate Fentanyl (Sublimaze) Naloxone (Narcan) Monitoring parameters during the procedure include: Heart rate, blood pressure, respirations Heart rate, blood pressure, and oxygen saturation Heart rate & rhythm, blood pressure, respirations, oxygen saturation and level of consciousness Heart rate & rhythm, blood pressure, oxygen saturation and respirations Heart rate, blood pressure, respirations, and oxygen saturation During the procedure the vital signs should be taken and documented: Pre and post procedure only Every 5 minutes Every 10 minutes Every 15 minutes As the physician feels necessary You are assisting with a colonoscopy on a patient. You position the patient on their stomach. The patient has been complaining of pain and you are instructed to give more Versed. Within a few minutes the oxygen saturation begins to drop. You should immediately: Arouse the patient Check the patient's respirations Turn the patient over All of the above The above patient's oxygen saturation continues to drop. You should: Leave the room to find an anesthesiologist Quickly finish the procedure so you can get the patient to the PACU Support the patient's airway and if necessary give oxygen by an Ambu-bag (manual resuscitation) and face-mask Have the nurse give naloxone (Narcan) The RN monitoring the patient receiving Sedation Analgesia: May also circulate in the room and get equipment from the hallway May not be engaged in any other activity during this period May not apply oxygen if needed Should do the preoperative history and physical prior to the procedure Naloxone (Narcan) can be used to reverse all of the following except: Midazolam (Versed) Meperidine (Demerol) Morphine What information is not needed in the history for a patient undergoing Sedation Analgesia: Allergies Past experiences with anesthetic drugs Pregnancy or menstrual history Last meal All of the above are necessary in the history All of the following are considered clear liquids except: Plain coffee or tea Breast milk Orange juice Apple juice Water Complications of Sedation Analgesia include: Respiratory depression. Hypotension Cardiac dysrhythmias All of the above. Discharge Criteria is best determined by which of the following? The ability of the patient to respond verbally. An Aldrete score of 8-10 or return to presedation level. When an hour has passed. Vital signs that are stable for 2 hours. The initial dose of Versed should be given over: a. 20 seconds b. 2 minutes c. 5 minutes d. 1 minute The preferred drug for anxiolysis in sedation analgesia is: a. Demerol b. Versed c. Morphine d. Romazicon Which of the following drugs DOES NOT have a side effect of respiratory depression? a. Demer;ol b. Versed c. Morphine d. Narcan Romazicon is indicated to reverse the effects of Benzodiazepine overdose: a. True b. False The purest opiod antagonist is _______ . a. Narcan b. Romazicon c. Activated charcoal d. Kayexelate The American Society of Anesthesiologists Classification of a patient with a severe systemic disturbance would be considered a ____________ patient: a. Class I b. Class II c. Class III d. Class IV e. Class V Personnel who administer or monitor patients receiving Sedation Analgesia/Moderate sedation must be able to perform which of the following: Demonstrate knowledge of the adverse reactions associated with drugs used for Sedation Analgesia/Moderate sedation Recognize an airway obstruction Assess heart rate and rhythm. All of the above Patients receiving Sedation Analgesia/Moderate sedation must have IV access established prior to the beginning of a Sedation Analgesia/Moderate sedation technique. a. TRUE b. FALSE When using "short acting" medication to achieve a Moderate Sedation/Analgesia technique, there is no need to monitor the patient beyond the procedure as the clinical effects of the medications used will end rapidly. a. TRUE b. FALSE Versed is useful for Sedation Analgesia/Moderate sedation when relief of anxiety and diminished recall of events associated with such procedures is desired. a. TRUE b. FALSE Romazicon has not been established as an effective treatment for hypoventilation due to benzodiazepine administration. a. TRUE b. FALSE Title: Aspects of Conscious/Sedation Analgesia Self Study Exam 4.0 C0NTACT HOURS Please note that C.N.A.s in California cannot receive continuing education hours for home study. Objectives At the completion of this program, the learners will be able to: Recognize indications and contraindications of Sedation Analgesia State appropriate monitoring techniques and requirements for patients experiencing Sedation Analgesia as stated in the hospital's policy on Sedation Analgesia. State necessity for baseline and frequent assessments of patients experiencing Sedation Analgesia. Identify medications frequently used for Sedation Analgesia, administration guidelines, and potential complications/side-effects. Evaluate and manage expected and unexpected outcomes of Sedation Analgesia. Completes module questions at 70% competency. Introduction Diagnostic and surgical procedures are being performed in a variety of settings throughout the hospital. Procedural Sedation involves all levels of sedation. This self-study program has been developed to increase your awareness and reinforce your understanding of the use of conscious or Sedation Analgesia for both adult and pediatric patients. This guide includes indications/contraindications for Sedation Analgesia, accepted medications, administration guidelines, and the hospital's Sedation Policy. Completion of this self-study packet includes learning the following material, satisfactory completion of the post-test and returning the post-test to the education department mailbox or your manager. Upon satisfactory completion of this self-study material, the participant will receive 2 hours of continuing education credit. SEDATION ANALGESIA The proliferation of new and improved technology and the diversification of medical practice, there has been an increase in the number of procedures done outside of the OR setting that do not require regional or general anesthesia but do require some degree of comfort and cooperation from the patient. This has resulted in increasing expertise and challenges for the Registered Nurse that includes learning the medications, techniques and safe practice of administering Sedation Analgesia. In keeping with this standardization, the Joint Commission has required there be documented evidence of competence and that it be reviewed on a periodic basis. Acquaintance with these standards and good practice will reduce your personal risk if a legal action might occur. Standards of training reduce risk. LIP = Licensed Independent Practitioner. DEFINITION Sedation Analgesia describes a state that allows patients to tolerate unpleasant procedures while maintaining adequate cardio-respiratory function and the ability to respond purposefully to verbal commands and/or tactile stimuli. Protective reflexes are maintained. The objectives of sedation are mood alteration, maintenance of consciousness and cooperation, elevation of the pain threshold with minimal changes in the vital signs, partial amnesia and a prompt safe return to the activities of daily living. This policy applies to all patients receiving in any setting for any purpose by any route moderate or deep sedation as defined in this policy. The organization currently defines four (4) levels of sedation and anesthesia, including the following: Minimal sedation or anxiolysis a drug induced state during which patients respond normally to verbal commands. Although cognitive function and coordination may be impaired, ventilation and cardiovascular functions are unaffected. Moderate sedation/analgesia a drug induced depression of consciousness during which patients respond purposefully to verbal commands either alone or accompanied by light tactile stimulation. No interventions are required to maintain a patent airway and spontaneous ventilation is adequate. Cardiovascular function is usually maintained. Deep sedation/analgesia a drug induced depression of consciousness during which patients cannot be easily aroused but respond purposefully following repeated or painful stimulation. The ability to independently maintain respiratory function may be impaired. Patients may require assistance in maintaining a patent airway and spontaneous ventilation may be inadequate. Cardiovascular function is usually maintained. Anesthesia consists of general anesthesia and spinal or major regional anesthesia and does not include local anesthesia. General anesthesia is a drug- induced loss of consciousness during which patients are not arousable even by painful stimuli. The ability to independently maintain respiratory function is often impaired. Patients often require assistance in maintaining a patent airway and positive pressure ventilation may be required because of depressed spontaneous ventilation or drug-induced depression of neuromuscular function. Cardiovascular function may be impaired. DIFFERENCES WITH I.V. SEDATION ANALGESIA & DEEP SEDATIONSedation AnalgesiaDeep SedationMood alteration Patient cooperative Protective reflexes intact Vital signs stable Local anesthesia provides analgesia Amnesia may be present Short recovery stay Perioperative complications infrequent Uncooperative or mentally handicapped patients cannot always be managed.Patient unconscious Patient unable to cooperate Protective reflexes obtunded Vital signs labile Pain eliminated centrally Amnesia always present Occasional prolonged recovery Perioperative complications reported in 25% - 75% of cases Useful in managing difficult or mentally handicapped patients. CALIFORNIA BRN CONSCIOUS SEDATION SCOPE OF PRACTICE Summarized from the BRN website 2/2002 It is within the scope of practice of registered nurses to administer medications for the purpose of induction of Conscious Sedation for short-term therapeutic, diagnostic or surgical procedures. In administering medications to induce Conscious Sedation, the RN is required to have the same knowledge and skills as for any other medication the nurse administers. This knowledge base includes but is not limited to: effects of medication; potential side effects of the medication; contraindications for the administration of the medication; the amount of the medication to be administered. The requisite skills include the ability to: competently and safely administer the medication by the specified route; anticipate and recognized potential complications of the medicine; recognized emergency situations and institute emergency procedures. Thus the RN would b held accountable for knowledge of the medication and for ensuring that the proper safety measures are followed. The registered nurse administering agents to render Conscious Sedation would conduct a nursing assessment to determine that administration of the drug is the patients best interest. The RN would also ensure that all safety measures are in force, including back-up personnel skilled and trained in airway management, resuscitation, and emergency intubation, should complications occur. RNs managing the care of patients receiving Sedation Analgesia shall not leave the patient unattended or engage in tasks that would compromise continuous monitoring of the patient by the registered nursed. Registered nurse functions as described in this policy may not be assigned to unlicensed assistive personnel. The RN is held accountable for any act of nursing provided to a client. The RN has the right and obligation to act as the clients advocated by refusing to administer or continue to administer any medication not in the clients best interest; this includes medications which would render the clients level of sedation to deep sedation and/or loss of consciousness. The institution should have in place a process for evaluating and documenting the RNs demonstration of the knowledge, skills, and abilities for the management of clients receiving agents to render Sedation Analgesia. Evaluation and documentation of competency should occur on a periodic basis. Addendum, Conscious Sedation As of 1995, safety considerations for Conscious Sedation include continuous monitoring of oxygen saturation, cardiac rate ad rhythm, blood pressure, respiratory rate, and level of consciousness, as specified in national guidelines or standards. Immediate availability of an emergency cart, which contains resuscitative and antagonist medication, airway and ventilatory adjunct equipment, defibrillator, suction, and a source for administration of 100% oxygen are commonly included in national standards for inducing Sedation Analgesia. HOSPITAL LOCATIONS The conscious sedation guidelines apply to all locations in the hospital where conscious sedation is administered. These locations include: G.I. and Bronchoscopy Procedure Room Intensive Care Unit Emergency Department Radiology Department - MRI and CT Scanner Operating Room and PACU Inpatient Rooms Respiratory Therapy Day Surgery PATIENT CRITERIA Sedation Analgesia/Moderate Sedation is used to minimize patient discomfort associated with invasive procedures where local or no anesthesia might produce unacceptable patient pain or anxiety. A second reason to select Sedation Analgesia would be the avoidance of general anesthesia or major conduction anesthesia with the associated increased patient risk. Monitored anesthesia care would be selected when a general or regional anesthetic is not chosen, and the patient's hemodynamics, physiologic parameters, and airway management merit continuous attention by an airway management specialist. It should be emphasized the transition between Sedation Analgesia/Moderate Sedation and an intravenous general anesthetic can be achieved with only small incremental doses of medications. PATIENT WHO MAY NOT BE SUITABLE FOR Sedation Analgesia/Moderate Sedation Certain patients may be at risk for developing complications related to Sedation Analgesia/Analgesia. These include: Uncooperative patients Mentally handicapped patients Patients with severe cardiac, pulmonary, hepatic, renal or central nervous disease Morbidity obese patients Pregnant patients Patients with alcohol or drug abuse Patients with history of sleep apnea Because of the possibility of the need for positive pressure ventilation, with or without endotracheal intubation, patients with atypical airway anatomy may also be at greater risk. Some factors associated with a difficult airway management include: History Previous problems with anesthesia or sedation Stridor, snoring, or sleep apnea Sysmorphic facial features (e.g., Pierre-Robin syndrome, trisomy 21) Advanced rheumatoid arthritis Physical Examination Habitus: Significant obesity (especially involving the neck and facial structures: Head & Neck: Short neck, limited neck extension, decreased hyoidmental distance (<3 cm in an adult). Mouth: Small opening (<3 inch an adult); edentulous, protruding incisors; loose or capped teeth; high, arched palate; macroglossia; tonsillar hypertrophy; non-visible uvula. Whenever possible, appropriate medical specialist should be consulted prior to administration of sedation/analgesia to patients with significant underlying conditions. The choice of specialist depends on the nature of the underlying condition and the urgency of the situation. For significantly compromised patients (e.g. severe chronic obstructive pulmonary disease, coronary artery disease, or congestive heart failure), or it if appears likely that sedation to the point of unresponsiveness or general anesthesia will be necessary to obtain adequate conditions, practitioners who are to specifically qualified to provide these modalities should consult an anesthesiologist. MEDICATIONS MEDICATIONS USED FOR Moderate sedation/analgesia: 1. Diazepam IV 2. Midazolam IV/IM/PO/Intranasal 3. Fentanyl IV Morphine IV/IM Meperdine IV/IM 6. Chloral Hydrate PO 7. Droperidol IV/IM (Adults Only) MEDICATIONS USED FOR Deep sedation/analgesia: 1 Etomidate IV 2 Ketamine IV/IM 3 Propofol IV 4 Methohexital IV A vast number of medications in the hospital formulary have the potential to produce a loss of airway reflexes. Medications administered for Sedation Analgesia/Analgesia and general anesthesia frequently differ by only a small amount. There often is no absolute quantity of medication that a patient can receive and Sedation Analgesia/Analgesia definitely is stated to be occurring. Only recommendations exist. It is incumbent upon the anesthesia care team to be vigilant and avoid this transition. Opiates All opiates given at equal anesthetic levels create with few exceptions - similar side effects. That is to say, if a nurse administers an equianalgesic dose of codeine and meperidine, the respiratory depression will be similar. Therefore, side effects - nausea and vomiting, constipation, biliary colic, and urinary retention - are equally likely to occur providing an equivalent dose of narcotics has been administered. The opiates do differ in their metabolism, duration of action, method of accumulation, and active metabolites. A few will have side effects that differ from the general effects listed above. Those not described above will be listed under morphine sulfate, which is the opiate to which all narcotics should be compared. MORPHINE General Morphine is the oldest and most widely used of all opiates. It remains the standard to which all other narcotics are compared. Morphine causes analgesia, sedation, and mood alteration. Analgesia can occur without loss of consciousness, although in large doses morphine produces obtundation and coma. When therapeutic doses are given to a patient in pain, pain relief or analgesia is reported. When an identical dose is administered to a pain-free individual, nausea and vomiting are common. Furthermore, the patient may experience an inability to concentrate with drowsiness or euphoria occurring as well. Cardiovascular System (CVS) Morphine has no direct effect on myocardial contractility. Large doses in healthy, supine normovolemic patients rarely produce hypotension. However, upon standing, about forty (40%) percent of healthy patients may demonstrate orthostatic hypotension. Hypotension is produced primarily through histamine release, although some can be attributed to a reduction in sympathetic tone. Bradycardia occasionally develops from direct vagal nucleus stimulation. Ventilation and Respiration Morphine (as other opioids) causes a dose - dependent depression of respiratory centers and elevation of resting pC02. Further, the brain stem becomes less responsive to carbon dioxide. A decrease in respiratory rate and increase in tidal volume occurs. The alteration of pulmonary volumes is insufficient to prevent the development of hyprcapnia. Death from opiate overdose is almost always associated with respiratory depression. If the patient is able to remain conscious, however, he will be able to initiate ventilation when asked. Morphine may cause bronchoconstriction that is mediated through a histamine release mechanism. Central Nervous System Effects Morphine in the absence of hypoventilation causes decreased cerebral blood flow. Opioids should be used with caution in head injured patients because of alteration of wakefulness and mental status. Elevation of pC02 by effecting the respiratory center may increase cerebral blood flow and elevate intracranial pressure. Other Side Effects Biliary spasm of smooth muscle may be confused with angina pectoris. Other GI effects include decreased peristalsis and increased pyloric sphincter tone. Opiates directly stimulate the chemotrigger zone within the brain stem and produce nausea and vomiting. Because of these events and pyloric and esophageal sphincter tone changes, patients receiving opiates should be considered to have "full stomachs". Additional problems include prolonged post-operative somnolence, respiratory depression, and incomplete intraoperative amnesia. These side effects are common to all opiates. Also, and subsequent respiratory depression. MEPERIDINE (DEMEROL) General Meperidine is a synthetic opiate developed in the 1930's as an atropine-like agent. While exhibiting opiate-like properties, it is chemically dissimilar. Meperidine is about one tenth (1/10) as potent as morphine with a shorter duration of action of about 2-3 hours. Meperidine is available in an oral form. Cardiovascular System (CVS) Meperidine has more side effects compared to morphine, including a negative inotropic effect when used in high doses. Because of its chemical similarity to atropine it can cause tachycardia. Ventilation and Respiration Meperidine's effects on ventilation and respiration are similar to morphine as it slows the respiratory rate and moderate effects on tidal volume. Central Nervous System Effects Large doses can produce tremors, muscles twitching, and seizures. This is largely thought to be secondary to an active metabolite (normeperidine) whose accumulation can cause seizures. 3. FENTANYL (Sublimaze) General Fentanyl (Sublimaze) is more rapid in onset (about thirty to sixty seconds) than morphine and is of much shorter duration. It is about 100 times more potent than morphine. Analgesic effect occurs within two (2) minutes of IV administration and lasts 30-60 minutes. Fentanyl in low doses (1-2 mcg/kg) is used for analgesia; in moderate doses (2-10 mcg/kg) as adjunct for the volatile anesthetics; and in high doses (50-150 mcg/kg) as a sole anesthetic. It is generally not used alone, but in combination with a benzocazepine. Available in 100mcg/2cc ampules. Cardiovascular System (CVS) High dose Fentanyl lacks a direct myocardial depressant effect, lacks histamine release, and is effective in suppressing the stress response associated with surgery. High dose fentanyl requires less intraoperative fluid replacement compared to morphine. Ventilation and Respiratory Fentanyl and its analogs when given rapidly intravenously in moderate or high doses produce skeletal muscle rigidity, especially in the truncal area. This "stiff chest syndrome" is occasionally so severe that adequate lung ventilation is not possible. In that case, rapid paralysis with succinylcholine or other muscle relaxant may be required. Rapid fentanyl injection speed increases the incidence of rigidity. B. BENZODIAZEPINES Benzodiazepines are some of the most widely used agents employed for IV Sedation Analgesia/Analgesia. While several dozen are presently being or have been marketed, only diazepam (Valium) and midazolam (Versed) will be discussed. A benzodiazepine antagonist flumazenil (Romazicon) is now available. Benzodiazepines have similar effects. Their use is more a reflection in the method of their study and marketing rather than specialized pharmacologic properties. Given in equipotent doses benzodiazepines have comparable effects. A major difference is the method of metabolism. Benzodiazepine IndicationsAmnestic, Anxiolytic, Anesthesia, Anticonvulsant, Hypnosis (sleep), Muscle relaxant Benzodiazepines have rapid onset and short duration of action. They lack analgesic (pain relief) properties. Benzodiazepines are rapidly taken into the brain and other highly perfused organs. Benzodiazepines and opiates have a synergistic effect. The most noteworthy is an increased incidence of airway obstruction and apnea when these medications are used together. All benzodiazepines undergo hepatic biotransformation. For this reason, benzodiazepines clinical presentation may differ when age and disease states such as cirrhosis are present. Furthermore, if hepatic blood flow is changed (cimetidine), or microsomal oxidase system effected by other metabolites (propranolol or alcohol), distinct changes may occur in the patient's pharmacodynamic presentation. DIAZEPAM (Valium) Diazepam is a longer acting benzodiazepine compared to midazolam. Diazepam undergoes extensive hepatic metabolism. Two major metabolites of diazepam, demethyldiazepam and oxazepam both have pharmacologic activity and contribute to diazepam's long duration of action. In the geriatric patient, the half-life may be up to 96 hours. Cardiovascular System (CVS) Diazepam administered intravenously in doses of 0.5 mg - 1.0 mg/kg results in mild reductions in blood pressure, peripheral vascular resistance and cardiac output. Occasionally hypotension will occur after even small doses of diazepam. Respiratory Diazepam causes depression of the slope of the ventilatory response to carbon dioxide, but the C02 response curve is not shifted to the right as it is after opioids. Occasionally small doses of diazepam may result in apnea. Depression of ventilation is exaggerated in the presence of other central nervous system depressant or in COPD. Other Diazepam reduces skeletal muscle tone via a spinal cord effect. It does not affect the neuromuscular junction. No interaction with paralytic muscle relaxants is present. Diazepam (0.1 mg/kg) has anticonvulsant activity and abolishes seizure activity in patients in status epilepticus or alcohol withdrawal although the effect is short lived. Drug Interactions Use of alcohol or opiates with diazepam increases central nervous system depressant effects. Cimetidine, by impaining hepatic metabolism increases the elimination half-life of diazepam. Diazepam crosses the placenta easily. An increased risk of congenital malformations has been associated with the use of diazepam during pregnancy. Adverse Effects Because diazepam is not water soluble, it has a much higher incidence of venous thrombosis and phlebitis. Choose an injection port as close to the vein as possible. Avoid injecting into small veins such as those of the hand or wrist. Other contraindications include known hypersensitivity and despite the fact that diazepam lowers intro-ocular pressure, glaucoma. MIDAZOLAM (Versed) Midazolam is a shorter acting water-soluble benzodiazepine that is twice as potent as diazepam. It has an elimination half time of 2.5 hours (range 2.1 - 3.4 hours) which increases to 5.6 to 9.0 hours in the elderly and 8.4 hours in obese patients. ILike diazepam, midazolam has sedative, anxiolytic, amnestic and anticonvulsant properties. Because of its shorter half-life and lack of active metabolites, Versed is the preferred drug for anxiolysis in Sedation Analgesia/Analgesia. Cardiovascular System (CVS) Midazolam when used as a sole anesthetic induction agent may produce reduction of cardiac index comparable to thiopental. Midazolam increases the heart rate and lowers blood pressure. The reason appears to be increased venous capacitance and decreased venous resistance. Other benzodiazepines including diazepam produce little reduction in myocardial hemodynamic parameters. However, both diazepam and midazolam are associated with stable cardiac function at induction. The proposed reason for this stability is maintenance of the baroreceptor reflexors. Ventilation and Respiration Benzodiazepines produce a dose - related depression central respiratory system depression Ventilation is depressed by 0.15 mg/kg midazolam, especially in those patients with COPD. Clinical hypoxemia and hemoglobin desaturation may be noted in patients receiving one-tenth this dose. Peak decrease in minute ventilation is nearly identical after administering equipotent quantities of midazolam and diazepam. The peak effect of midazolam - induced respiratory depression occurs at three minutes following injection and remains for approximately fifteen minutes. Respiratory depression is more pronounced in geriatric and COPD patients. Apnea occurred in 20% of 1,130 patients given midazolam and 27% of patients given thiopental for induction. Reves and Glass feel that a synergistic effect of the benzodiazepines and opiates may occur by acting at different receptors. Central Nervous System Effects Compared to the barbiturates, benzodiazepines have similar but lesser effects on cerebral metabolism, cerebral vascular resistance, cerebral perfusion pressure and intraocular pressure. Maximal CNS effects occur approximately three to five minutes after injection. Benzodiazepines like barbiturates, also produce either no analgesia or cause a slight hyperalgesia (increased pain). Benzodiazepines produce a consistent amnestic effect compared to the barbiturates. The amnesia may be anterograde (lack of recall) and postoperative. In both cases amnesia is greater than the barbiturates. Dose related decreases of cerebral blood flow and oxygen consumption are observed. Other Side Effects Untreated glaucoma (narrow angle) and hypersensitivity are also known contraindications to its use. Midazolam crosses the placenta, although the effects are not known. COMPLICATIONS OF BENZ0DIZEPINES Benzodiazepine has few side effects. The incidence of anaphylactic reactions is extremely low. The major complication with diazepam appears to be pain upon IV injection. Midazolam, due its greater potency, after first appearing on the market produced significant episodes of respiratory side effects related to apnea. With increased physician awareness, doses have been reduced and this problem seems to have declines. ANTAGONISTS USED IN SEDATION ANALGESIA Reversal Agents Example of Reversal agents needed are (Narcan and Romazicon) NALOXONE (Narcan) Naloxone is one of several opiate antagonists presently on the market. Naloxone acts as the opiate receptor by displacing opioid antagonists. Naloxone binds to opiate receptors but does not actuate them so antagonism occurs. It is considered among the "purest" of opioid antagonists. It antagonizes opioid effects mediated by all receptor types but has a higher affinity for muscle receptors compared to kappa receptors. Naloxone has a very short plasma half-life. Its entry and decline in brain tissue is very rapid. Naloxone's duration of clinical effect is frequently less than of the opioid agonist, so patients must be monitored carefully for signs of re-narcotization. Indications Naloxone's primary use is the reversal of respiratory depression. It also produces a parallel reversal of analgesia. Some feel it is possible to carefully titrate naloxone to reverse respiratory depression leaving analgesia unaffected. This has proved extremely difficult in the clinical setting. Side Effects Large boluses of naloxone have been reported to cause hypertension, pulmonary edema, ruptured cerebral aneurysms, cardiac arrest, and death in narcotized patients. The postulated mechanism of massive cardiovascular stimulation after reversal has been abrupt awakening and pain causing a massive sympathetic response. Instances of hypertension, hypotension, ventricular tachycardia, and ventricular fibrillation have been reported in patients who had pre-existing cardiovascular disorders. Naloxone also may unmask physical dependence, precipitate acute withdrawal syndrome, and elevate catecholamines. FLUMAZENIL (Romazicon) Mechanism of Action Benzodiazepines produce sedation by stimulation of a subunit of the GABA receptor. Flumazenil blocks benzodiazepine agonists from this stimulation making the patient more alert. Flumazenil is an antagonist for such drugs as Valium and Versed. Indications Flumazenil is indicated to reverse the effect of benzodiazepine overdosage. Side Effects At present, the benzodiazepine antagonist flumazenil appears to have few side effects in the average patient. Adverse effects such as dizziness, headache, nausea and vomiting, sweating, flushing, pain at injection site have been reported in patients who are dependent on benzodiazepines. The possibility exists of inducing seizures in patients who use benzodiazepines for seizure control. DRUG ADMINISTRATION AND I.V. THERAPY GUIDELINES Note: Please see your facility policy and procedures. Patient Instruction that conscious awareness of activity will be limited to anticipate drowsiness/sleepiness lasting a short period that ability to hear, especially instructions, will remain that BP cuff and pulse ox probe will remain in place during sedation/procedure that recovery period will be relatively short (30-60 minutes) that any necessary ambulation during recovery MUST be supervised that a responsible person should drive outpatient home and be available for the day Administration Administer initial dose, then titrate medication to desired effect. Recommended initial IV doses for drugs most commonly used are:  Adult PediatricDiazepam (Valium)2 mg to 10 mg0.25 mg/kgLorazepam0.05 mg/kg0.03 - 0.05 mg/kgMidazolam (Versed) 0.07 mg to 0.08 mg/kg (maximum dose 2.5 mg) 0.035 mg/kgMorphine0.025 to 0.2 mg/kg0.05 to 0.2 mg/kgMeperidine (Demerol)  1 to 1.5 mg/kg 1 to 2 mg/kgFentanyl1 mcg to 2 mcg/kg1 mcg to 2 mcg/kgSufentinil0.1 to 0.2 mcg/kg0.1 to 0.2 APPENDIX A SEDATION / ANALGESIA : GUIDELINES FOR MEDICATION From the internet link: http://classes.kumc.edu/general/hospital/cseducation/appendixa.htm Narcotics- For pain control only. Not appropriate for sedation, amnesia, or relief of anxiety. Drug Age Route Dose/Titration Peak Onset Duration Side Effects/Precautions Morphine (Various brands) Adults PO 10-30mg PO: 60 minutes IV: <20 minutesPO/IV: 7 hours T1/2 = 2-4 hours Dose dependent-Respiratory depression, orthostatic hypotension, nausea, itching, painful injection. Decrease dosages in hepatic and renal insufficiency, and elderly, debilitated patients. PR 10-20mg IV 2.5 mg given slowly initially 5-20mg Children PO/PR 0.2-0.5mg/kg. Max of 15mg IV 0.05 - 0.1 mg/kg 5 minutes prior. Max of 15mg Fentanyl (Various brands) Adults IV 1 - 2 m g/kg in 25 m g increments, slowly titrated over 1-2 minutes PO: <20 minutes IV: 1 - 3 minutes PO/IV: <60 minutes T1/2 = 2-4 hours Respiratory depression, apnea, hypotension, bradycardia, dizziness, nausea. Decrease dosages in hepatic and renal insufficiency and elderly, debilitated patients. Children IV 1-2mcg/kg every 30-60 minutes Meperidine (Demerol ) * For GI & endoscopy procedures* Adults IV 0.5 -1.0 mg/kg Given in 25 mg increments slow injection IV: 1 - 5 minutes PO/IV: 2-4 hours T1/2 = 3-5 hours Respiratory depression, apnea, hypotension, tachycardia, bradycardia, dizziness, nausea. Decrease dosages in hepatic and renal insufficiency, and elderly, debilitated patients. Children IV 1-2mg/kg 30-60 minutes prior to procedure Narcotic Reversal Agent Drug Age Route Dose/Titration Peak Onset Duration Side Effects/Precautions Naloxone (Narcan ) Adults & Children IV Dilute in 10mls and titrate to effect. Max of 2mg in adults and 0.01mg/kg in children. 1-2 minutes 1-4 hours T = 1.5 hours Pulmonary edema, nausea, sweating, tachycardia. Benzodiazepines- For sedation, amnesia, and relief of anxiety only. Not for pain control. Drug Age Route Dose/Titration Peak Onset Duration Side Effects/Precautions Midazolam (Versed ) Adults IV 1-5mg, given in 1 mg increments over 2 minutes titrated to effect PO: 30-60 minutes IV: 1-5 minutes PO/IV: 2-6 hours T1/2 = 1-4 hours Respiratory depression, hypotension, bradycardia, hiccups, apnea. Decrease dosages in hepatic and renal insufficiency, and elderly, debilitated patients. Children PO (inj) 0.2-0.4mg/kg 30-45 minutes prior to procedure IV 0.05mg/kg 3 minutes prior to procedure. Max of 0.2mg/kg or 2.5mg Benzodiazepine Reversal Agent Drug Age Route Dose/Titration Peak Onset Duration Side Effects/Precautions Flumazenil (Romazicon ) Adults IV 0.2 mg / min in incremental doses up to 1 mg IV: 1- 3 minutes 45-90 minutes T1/2 = 30-90 minutes Hypoventilation, may precipitate seizure. Children 0.01-0.2mg/kg/min initially, 0.005mg/kg incremental doses up to 0.2mg total Other Agents Drug Age Route Dose/Titration Peak Onset Duration Side Effects/Precautions Chloral Hydrate (Various Brands) Adults PO 500 - 1000mg 30 min prior to procedure 0.5-1 hours 4-8 hours T1/2 = 8-11 hours GI irritation, nausea, vomiting, diarrhea, disorientation, drowsiness. Decrease doses in renally insufficient patients and avoid in hepatic impairment. Children Hypnotic-50mg/kg up to 1000mg 30 minutes prior to procedure Sedative-25mg/kg up to 500 mg 20 minutes prior to procedure  ASA PHYSICAL STATUS AND ANESTHETIC ASSESSMENT One of the new requirements of anesthesia care mandated by regulatory agencies and the Joint Commission is assessment by non-anesthesia providers of the American Society of Anesthesiologists physical status categorization system. The reasons for this requirement ultimately relate to a desire to determine and accumulate hospital specific morbidity and mortality data like currently being released for other procedures such as coronary bypass surgery. While many factors influence anesthesia morbidity and mortality, one important consideration is the patient's overall physical condition. In the ASA physical assessment system, patients are assigned a numeric score ranging between one and five based upon pre-existing medical conditions. One is a completely healthy patient with no medical problems. A five is a moribund patient not expected to survive with or without surgery. An E for emergency procedure may also be assigned this classification system. The classification system and examples of representative medical conditions are reproduced in tabular form in the following section. Presently the responsibility for assigning physical status resides with the physician. AMERICAN SOCIETY OF ANESTHESIOLOGIST (ASA) PHYSICAL STATUS CLASSIFICATION SYSTEMCLASSASA CRITERIAEXAMPLE1A Normal Healthy Adult No organic, physiologic, biochemical or psychiatric disturbance. A healthy patient without medical problems Patients without shock, blood loss or systemic signs of injury are present in an individual who otherwise fall into Class 1. Congenital deformities unless they are causing a systemic disturbance2A patient with mild systemic Disease which may or may not be related to reason for surgery. (Examples: hypertension, diabetes mellitus)Anemic Chronic bronchitis Essential hypertension with medication Medically controlled diabetic with p.o. meds3Patient with severe systemic Disease (Examples: heart disease, poorly controlled hypertension)Insulin controlled diabetic. Immunosuppressed. Moderate degree of pulmonary insufficiency. Stable coronary artery disease. Asthma under treatment. Extreme obesity.4Patient with severe systemic disease that is a constant threat to life. (Examples: Congestive hart failure, persistent angina pectoris).Organic heart disease showing marked signs of cardiac insufficiency. Persistent anginal syndrome. Active myocarditis. Advanced degree of pulmonary, hepatic, renal or endocrine insufficiency. 5Moribund patient who is not expected to survive without the operation. Surgery is the last resort. (Example: uncontrolled bleeding, ruptured AAA) Criteria for monitored anesthesia care includes, but is not limited to: Patients over 70 years of age. Patients with underlying cardiorespiratory risks. Patients receiving IV conscious sedation medications greater than the drug dosage guidelines for nurse administration. Pregnant in 1st trimester. Sedation ScoreCriteriaDefinitions 1 2 3 4 5 6 Awake Anxious and/or agitated, baseline agitated state Cooperative, oriented and tranquil. Responsive to commands Asleep Quiet, asleep, with brisk response to light glabellar tap (tactile stimulus) or loud auditory stimulus. Sluggish response to light glabellar tap (tactile stimulus) or loud auditory response. Little or no response to stimuli. IV SEDATION ANALGESIA PROTOCOL ALDRETE SCORING GUIDE ALDRETE SCORING GUIDEOn ArrivalOn DischargeAble to move 4 extremities voluntarily or on command = 2 Able to move 2 extremities voluntarily or on command = 1 Able to move 0 1 extremity voluntarily or on command = 0ActivityDeep Breathing and Cough = 2 Dyspnea or limited breathing = 1 Apneic = 0RespirationBP = 20 mm of Preanesthetic level = 2 BP = 20-50 mm of Preanesthetic level = 1 BP = 50 mm of Preanesthetic level = 0CirculationFully awake = 2 Arousable on calling = 1 Not responding = 0ConsciousnessPink or normal skin color = 2 Pale, dusky, blotchy, jaundiced, other = 1 Cyanotic = 0ColorTOTALS Patient Assessment All patients require a documented history and physical on the chart prior to receiving Sedation Analgesia. The assessment should include, but is not limited to, NPO status, baseline vital signs, weight, airway status, current medications, allergies, pertinent medical & anesthetic history, mental status, and lab studies per hospital policy. Elderly patients, very young patients, those with kidney or liver metabolism problems, and psychologically immature or developmentally disabled patients may need alternative methods of sedation and/or anesthesia. It should also be determined when the patient last ate and drank. The recommendation is: no solid food or full liquids for at least 6-8 hours and no clear liquids for at least 3-4 hours prior to the sedation. In cases where sedation is part of an emergency procedure, careful clinical judgment is required to determine an appropriate level of sedation that does not place the patient at an unacceptable risk for regurgitation and aspiration. The procedure and sedation may be delayed until the risk is diminished. In cases where the procedure can not be delayed without causing further harm to the patient, practitioners should follow guidelines to prevent aspiration as outlined in the hospital's policy on Procedural sedation. Example of Sedation Analgesia Overview PRE-SEDATIONASSESSMENT ON ALL AGES Pre-conscious sedation assessment to be performed by the registered nurse shall include: Baseline vital signs including heart rate, cardiac rhythm, blood pressure Respiratory rate and O2 saturation. Level of consciousness: Mental status NPO status 2.0 Pre-Conscious Sedation Patient Evaluation. A. An appropriate patient assessment must be performed by a credentialed practitioner prior to the administration of conscious sedation. The pre-conscious sedation assessment must include: Patient interview Relevant history including past anesthetic history, current medications, allergies, alcohol and other substance abuse history and smoking history Physical assessment including an assessment of at least airway, heart and lungs Review of the results of relevant diagnostic testing. Choice of anesthetic agents to be utilized Anesthetic plan Informed consent for Conscious Sedation/anesthesia B. If a practitioner is also performing a procedure, then informed consent for the procedure must also be obtained. Informed consent for the sedation/analgesia and any procedures to be performed are to be documented by the physician in the medical record C. The patient must be re-evaluated by an appropriately credentialed practitioner immediately before conscious sedation use to ensure that the patient is still a suitable candidate for the anesthetic plan that has been proposed. 3.0 There must be a hospital consent signed by the patient/agent that verifies informed consent for conscious sedation and any procedures to be performed unless there is documentation in the medical record that an emergency exists. 4.0 Intravenous access should be secured in all adult patients and all pediatric patients receiving intravenous medications. For pediatric patients receiving conscious sedation through routes other than intravenously, the patients physician may determine if intravenous access is necessary. If it is determined that intravenous access is not necessary, then skilled personnel and equipment necessary to start and intravenous line should be immediately available. Equipment and Supplies Prior to sedating the patient the health care practitioner needs to assure that all monitoring equipment required for Sedation Analgesia (see TABLE 2) is present and functioning. Since Sedation Analgesia depresses the level of Moderate or Conscious ness while allowing the patient to maintain their airway independently, the physician and nurse's responsibility must focus on assessing parameters that may be impacted by sedating medications. Observation of the patient before, during and after the period of sedation is crucial. Discrete changes in patient status are often observed before noticeable changes in vital signs and other parameters occur. Consistent with the ABC's of resuscitation - Airway, Breathing, and Circulation - the ability to positionally maintain an open airway should be assessed and documented by determining the level of consciousness and arousability of the patient. Baseline level of Consciousness prior to the sedation should also be assessed and documented. Breathing should be assessed through the use continuous pulse oximetry and observation of respiratory rate, depth and effort. Circulation should be assured through blood pressure, pulse and cardiac rhythm monitoring. Hypoxemia from any cause is often reflected by cardiac dysrhythmias (especially bradycardia), necessitating the need for continuous heart monitoring throughout the period of sedation and recovery. Hemodynamic changes can reflect physiological alterations such as circulating volume changes, vasoconstriction, vasodilatation and other effects of sedation and/or the accompanying procedure. A patent, operational intravenous site should be established and maintained throughout the recovery stage of sedation. Resuscitation equipment and personnel skilled in advanced life support including airway management should also be available. NPO Status The following NPO guidelines apply for otherwise health patients. Variations in these guidelines may be indicated because of the patients clinical presentation. 1. Patients less than 2 years old - may take clear liquids up to 2 hours before procedure and may take solids up to 6 hours before procedure. 2. Patient greater than 2 years old - may take clear liquids up to 4 hours before procedure and may take solid up to 6 hours before procedure. Procedural Sedation Overview Equipment needed for conscious sedation includes: A. Cardiac Monitor B. Pulse oximeter C. Noninvasive Blood Pressure Monitor D O2 and suction at bedside E. Emergency crash cart with defibrillator including all emergency drugs F. Ambu bag and mask ventilation apparatus G. Appropriate oral and nasal airways H. Reversal agents including: Naloxone and Flumazemil I. Intubation tray J. IV supplies and equipment K. Electrical outlet with emergency power L. Telephone Emergency Resuscitative EquipmentOxygenSystem capable of delivering 100% at 10 L/min for at least 30 minutesSuctionApparatus capable of producing continuous negative pressure of 150 torrAirway ManagementFace masks (all sizes) Oral and Nasal airways Endotracheal Tubes LaryngoscopesMonitorsPulse Oximeter with both visible and audible displays Cardiac Monitor Automated Blood Pressure DeviceResuscitative Equipment/MedicationsAmbu -Bag Defibrillator with EKG recorder capabilities Emergency Drugs including Naloxone (Narcan), Flumazenil (Mazicon), Ephedrine and Epinephrine ACLS Protocols MONITORS The intent of monitoring for Sedation Analgesia/Analgesia is to have equivalent monitoring to that performed in the operating room. Monitors such as EKG, pulse oximetry and frequent blood pressure monitoring are now mandated rather than suggested by regulatory agencies such as the JCAHO and DHS. In addition, equipment once thought desirable is now required if routinely employed in the operating room. Patient monitoring is the primary ongoing responsibility of the nurse administering Sedation Analgesia/Analgesia. The nurse who will be performing this duty is responsible for assessment and teaching. The RN should connect the patient to monitors listed below, obtain and record a baseline assessment. After this baseline, the administration of sedative medications may begin. This nurse should have no other responsibilities during the procedure. Below is a list of equipment and monitors that must be placed prior to the commencement of Sedation Analgesia/Analgesia. The nurse should be familiar with the operation of function of monitors. IV access Pulse oximeter Automated or manual blood pressure device Cardiac monitor Oxygen source with positive pressure ventilation capabilities Suction equipment in room Crash cart Selection of laryngoscope blades with handle and endotracheal tubes (intubation tray) Narcan (Naloxone) and Romazicon (flumazenil) shall be immediately available The eyes, ears and sensorium of a well-trained nurse familiar with the medications and procedure may be the best monitor of all. The nurse will provide continuous observation with frequent recording of vital signs. Baseline vital signs, oxygen saturation level, heart rhythm, and level of consciousness are the minimum assessment parameters obtained and documented prior to sedation. During the medication administration, the sedating period and the recovery phase, these parameters should be monitored and documented at least every five minutes. The nurse should immediately report to the physician any variations from baseline such as: +20 % in BP or pulse, cardiac dysrhythmias (continuous), >5 % below baseline of oxygen saturation (continuous monitoring), dyspnea, apnea, or hypoventilation, diaphoresis, inability to arouse the patient, the need to maintain the patient's airway mechanically, or other undesired or unexpected patient responses. Use of the Aldrete scoring system is a helpful adjunct in determining the patient's ability to follow commands, respiratory effort, circulatory status, level of consciousness and ventilatory status. Timeline for Monitoring Continuous monitoring of Pulse Oximeter, Cardiac Monitor, BP, P, and Respiration. Before MedicationMedicationProcedure StartProcedure EndDischarge Criteria MetObtain baseline vital signs, LOCVital signs, LOC Q 5 minutesVital signs, LOC Q 5 minutesVital signs, LOC Q 5 minutes x 3 then q 15 min until discharge. Nursing Responsibilities Responsibilities of the RN include: Knowledge of the goals and objectives of IV Sedation Analgesia Patient assessment Administration of medications per physician's orders Uninterrupted observation and monitoring of the patient from time of Sedation Analgesia until time of discharge Documentation (as described below) Provision of appropriate emergency intervention as necessary Physician Responsibilities Responsibilities of the physician include: Responsibilities of the Physician include: Completion of history and physical Completion of informed consent Ordering of the medication, dosage and route of administration Directing and providing of emergency interventions as necessary Dictation of operative note immediately after completion of procedure (as per hospital policy) Documentation Documentation should include: Dosages, route, time and effect of all drugs used Type and amount of fluids administered, including blood and blood products, monitoring devices or equipment used Heart rate, rhythm, blood pressure, respiratory rate, oxygen saturation, and level of consciousness. Interventions and the patients response to the interventions Untoward or significant patient reactions and their resolution or outcome Patient Monitoring The patient must be continuously monitored from the start of Sedation Analgesia until the time discharge criteria are met. Baseline vital signs, oxygen saturation level, heart rate, rhythm, and level of consciousness are the minimum assessment parameters obtained and documented prior to sedation. The patient should be monitored at 5-minute intervals during the procedure, and at 5-15 minute intervals during the recovery phase, and at any significant event in either phase. THE RN MONITORING THE PATIENT MAY NOT BE ENGAGED IN ANY OTHER ACTIVITY DURING THE PERIOD OF SEDATION ANALGESIA! The nurse should immediately report any unexpected response by the patient to the physician. These include, but are not limited to variations from baseline +20 % in BP or pulse; cardiac dysrhythmias (continuous); > 5 % below baseline of oxygen saturation (continuous monitoring); dyspnea, apnea, or hypoventilation; diaphoresis (may signify myocardial ischemia); inability to arouse the patient; or the need to maintain the patients airway mechanically. Once the patient's vital signs are at pre-sedation levels or at least 30 minutes have passed since the last sedating medication, monitoring of physiological parameters may be increased to every 15 minutes until the patient returns to pre-sedation level of consciousness and stability. Procedural Sedation Overview Intra-Conscious Sedation and Procedure Treatment, Monitoring and Documentation: Supplemental oxygen automatically given to prevent hypoxia B. The objective of monitoring the patient during conscious sedation is to ensure the adequacy of ventilation, oxygenation, and circulatory function. The following guidelines for monitoring are considered a minimum standard, which is required for any patient receiving conscious sedation. Departments may develop their own specific guidelines that delineate requirements for monitoring of special patient populations that exceed the minimum standards set below. 1. Cardiac rhythm will be monitored continuously and documented at least every fifteen (15) minutes. 2. Oxygen saturation will be monitored continuously and documented at least every fifteen (15) minutes. 3. Document vital signs, pain level, and level of consciousness every (5) minutes. When respirations cannot be monitored, the oxygen saturation will be used to evaluate. Oxygen saturation will be the only monitoring during an MRI. Procedural Documentation 1. Procedure performed (as relevant) 2. Start and end times 3. Personnel involved 4. Name and dose of all drugs used including oxygen (time, route, and patient response) 5. Type and amount of IV fluids administered 6. Record of all vital signs, including pain assessment 7. Patient status at the end of the procedure 8. Post-procedure diagnosis 9. Unusual events or interventions Significant changes to be reported immediately by the registered nurse to the attending practitioner: 1. Heart rate < 50 or > 120 beats per minute 2. Cardiac rhythm changes 3. Oxygen saturation changes: a. Adult 10% drop or saturation < 90 b. Pediatric 5% drop or saturation < 90 4. Level of consciousness changes: a. Change in which the patient cannot communicate verbally or appropriately for age Sedation score > 2 (Attachment B) 5. Tissue perfusion changes with cyanosis, mottled skin or clamminess.  PROCEDURE MONITORING Baseline vital signs are obtained prior to the initiation of the procedure. While monitoring is continuously performed during the procedure, it is required that vital signs be recorded with the frequency listed below: BP monitored continuously and recorded at least every 5 minutes or more frequently if necessary. RR monitored continuously and recorded at least every 5 minutes or more frequently if necessary Pulse monitored continuously and recorded at least every 5 minutes or more frequently if necessary Continuous oxygen saturation monitored continuously and recorded every 15 minutes Continuous cardiac rhythm monitored continuously and recorded every 15 minutes End tidal carbon dioxide monitored continuously and recorded every 15 minutes if the patient is intubated. PULSE OXIMETRY One of the more important monitors for Sedation Analgesia/Analgesia is pulse oximetry. The pulse oximeter was developed in the early 1980's and measures the amount of oxygen carried on hemoglobin in the arterial blood. This monitor promptly and reliably identifies hypoxemia far better than clinical signs such as cyanosis or disorientation. Early identification of hypoxemia should avoid extreme situations and lead to improve outcomes. It is important to emphasize that pulse oximeters measure oxygen saturation of hemoglobin, while blood gases measure the amount of dissolved oxygen in plasma. These values are by no means identical; oxygen saturation does not equal PaO2. The relationship between these two values (SaO2 and Pa O2) must be understood, so they are not mistaken for each other. The oxyhemoglobin dissociation curve is what compares this relationship, and gives us the following approximate values: SaO2 = hemoglobin saturation of arterial blood PaO2 = partial pressure of oxygen measured in ABG's SaO2PaO295%80mm Hg90%60mm Hg85%50mm Hg Pulse oximetry does have limitations. Clinical situations may reduce its accuracy. Measuring only oxygenation does not measure the patient's ventilation nor does it detect carbon dioxide accumulation or excretion. Additionally, supplemental O2, by delaying the onset of hypoxemia, may delay the detection of apnea by pulse oximetry. Pulse Oximetry Factors that May Lead to an Unreliable Reading EQUIPMENT FACTORSMotion at sensor site Ambient light inaccurate SpO2 readings have been reported from surgical lamps, infrared lights and fiberoptic surgical units.PATIENT FACTORSAbnormal hemoglobin's to include Met Hemoglobin, Carboxyhemoglobin and possibly sickle cell anemia IV dyes - methylene blue, indocyanine green Vasoconstriction, e.g. with hypothermia or vasopressors Hypotension Rapid or erratic heart rates where the pulse pressure does not correlate with heart rate Anemia: Hematocrit is less than 10% may cause underestimation of oxygen saturation Nail polish: green, blue or maroon nail polish, artificial nails Skin pigments: In a few very deeply pigment individuals, pulse oximetry is not possible because red light cannot be transmitted. Emergency Interventions Overdose or adverse drug reactions may cause respiratory depression, hypotension, and impaired cardiac function. The Physician and the RN must be ready to intervene if these complications arise. Emergency interventions include, but are not limited to, airway management, reversal of sedating medications and other measures such basic life and advanced cardiac life support. Respiratory Depression and Hypoventilation Decreased or shallow respirations and decreased oxygen saturation demonstrate respiratory depression. Respiratory depression should be treated with oxygen and airway management. The most effective way to open the airway is the head tilt-jaw lift. Often this maneuver alone is enough to improve ventilation and 02 saturation. Every patient should have oxygen via nasal cannula throughout the procedure. If the patient is breathing and the oxygen saturation is low, the flow of the nasal cannula 02 may be increased. Encourage the patient to take deep breaths. If the patient is breathing but the oxygen saturation remains low, change the nasal oxygen to a 100% non-rebreathing facemask. If efforts remain unsuccessful, bag the patient by connecting the facemask to an Ambu-bag. Continue to bag the patient until the oxygen saturation improves. If the condition does not improve, intubate the patient. If the patient is breathing and has adequate oxygen saturation but cannot maintain his or her own airway, an artificial airway is indicated. A nasal or oral airway may be used. The nasal airway may be more tolerable than an oral airway for a conscious patient. The appropriate size nasal airway should be selected by measuring the distance from the tip of the patient's nose to the earlobe. Apply lubricant and insert into one nostril. If resistance is encountered, slight rotation of the tube will facilitate insertion. The oral airway size is determined by measuring the distance from the corner of the patient's mouth to the earlobe. The airway is inserted with the point towards the roof of the mouth and then inverted as the pharynx is reached. Respiratory depression can progress to respiratory arrest. If the patient is not breathing, begin artificial respirations immediately intubate the patient. Cardiac Complications and Hypotension Hypotension is another complication of Sedation Analgesia. Hypotension may be easily corrected by placing the patient in "Trendelenburg" (head-down) position and giving IV fluids. If this intervention does not improve the blood pressure, more aggressive drug therapy is needed. Call for help STAT before the situation gets worse. Another potentially lethal complication of Sedation Analgesia is cardiac arrhythmias. Cardiac arrhythmias must be recognized and treated quickly for positive patient outcomes. REMEMBER: IF YOU ARE IN DOUBT IT IS SAFER TO CALL FOR HELP! However, if you patient arrests, begin CPR immediately and page Code Blue. Procedural Sedation Overview POST-PROCEDURE ASSESSMENT AND INTERVENTIONS 1.0 Post-Conscious Sedation and procedure (if relevant) Monitoring and Recovery Vital signs including blood pressure, pulse, respirations, oxygen saturation, and pain assessment recorded upon arrival in the recovery area and at least every 15 minutes until discharge criteria met. Continuous EKG monitoring with cardiac rhythm documented every 15 minutes. The physician relevant to further monitoring and recovery will evaluate patients with an Aldrete score of less than 8. Level of consciousness recorded every 15 minutes until discharge criteria met. A written record to be maintained which describes the following: 1. IV fluids administered and time IV discontinued 2. Name and dosage of all drugs used including oxygen (time, route, patient response and administered by whom). 3. PO fluids or nourishment Unusual events Record of Vital Signs Disposition of patient Mode of transportation Discharge instructions and documentation of patient understanding Person responsible for patient at discharge Protocol to continue until patient meets criteria that allows for discontinuing conscious sedation protocol. F. O2 saturation to be done on admission to the unit and prior to discontinuing conscious sedation protocol. Discharge Criteria Patients who have received Sedation Analgesia must go to a recovery area with comparable monitoring capabilities post procedure. Monitoring will be continued at 5-15 minute intervals. The patient must meet specific discharge criteria for the recovery area before moving to another location such as, Lounge Recovery (for outpatients), the floor (for inpatients), or home (as in the case of the Emergency Department). Meeting these criteria ensures that the patient has returned to a safe physiological level of functioning. The Aldrete scoring scale for determination of patient status. Use of the Aldrete scoring system is a helpful adjunct in determining the patient's ability to follow commands, respiratory effort, circulatory status, level of consciousness and ventilatory status. The nurse is responsible for patient advocacy, patient and family education, medication administration, documentation, preparedness, evaluation and the overall monitoring of the patient pre-, during, and post-sedation. Variances from the expected sedation level (loss of ability to maintain own airway, etc.) will be documented, reported and evaluated. Adherence to the hospital policy on Sedation Analgesia provides the nurse with a framework and guidelines to accomplish these tasks. Transfer/Discharge Criteria 1.0 Discontinuation of Monitoring Protocol and Transfer Criteria for transfer to another hospital Unit O2 saturation of 95% or > on room air or return to pre-conscious sedation level Last dose of narcotic antagonist (Naloxone) or Benzodiazipine antagonist (Flumazenil) at least 30 minutes prior to transfer. C. Aldrete scoring of at least 8 or return to pre-conscious sedation level D. Activity score of at least 2 E. Respiratory score of at least 2 F. Cardiovascular score of at least 1 G. Color score of at least 2 H. Consciousness score of at least 1 A. 2.0 Discharge Criteria If a A A. Patient is to be discharged from the hospital following conscious sedation, the patient must be discharged following evaluation by a physician, or by a RN following the standardized procedure. B. In addition to the transfer criteria described above, if a patient is to be discharged by a registered nurse following the standardized procedure then the following criteria must be met: 1. Last dose of depressant drug administered at least 15 minutes prior to discontinuing protocol or discharge from the hospital if IV and 30 minutes if IM. Last dose of Benzodiazipine administered at least 30 minutes prior to discontinuing protocol or discharge from hospital. Last dose of Valium given at least 60 minutes prior to discontinuing protocol or discharge from hospital. 4. Last dose of narcotic antagonist (Naloxone) or Benzodiazipine antagonist(Flumazenil) administered at least 45 minutes prior to discontinuing protocol or discharge from hospital. 5. Discharge instructions given to patient and/or patients family, including instructions regarding pain management. General Principles and Guidelines for Pediatric Sedation Analgesia Sedation Analgesia for Pediatric Patient Please refer to hospital guidelines. The definition for Sedation Analgesia for pediatric patients (under 18 years old, not neonates) is the same as for adult patients: a depressed level of consciousness with the ability to independently and continuously maintain a patent airway and respond appropriately to physical stimulation. As with the adult patient, pediatric patients may need to be sedated for surgical or diagnostic procedures. These patients will need to be evaluated for past medical history, ability to cooperate, psychological or developmental disabilities, potential for unpredictable reactions to medication, NPO status, and ability to communicate. Informed consent must be obtained from the parent or guardian of the child prior to medication administration. Education about Sedation Analgesia and follow up care of the child needs to include both the child and the adults accompanying the child. The general guidelines for NPO status of pediatric patients are as follows: AgeSolid and non-clear liquidsClear LiquidsChildren > 36 months6 hours2 hours6-36 months6 hours2 hours< 6 months4 hours2 hours It is recognized that certain emergency procedures may be performed with a sub-optimal NPO status. Careful clinical judgment is required to determine an appropriate level of sedation that does not place the patient at an unacceptable risk of regurgitation and aspiration of gastric contents. Monitoring for the sedated child is similar to that of the adults. The equipment should be appropriate to the age and size of the child. The ABC's (airway, breathing, and circulation) must be monitored and the nurse should be ready with the knowledge and equipment that may be needed for emergency resuscitation. (Pediatric Code Cart) Medication dosage is extremely important and is usually calculated on weight so an accurate weight must be obtained prior to medication administration. The physician must adhere to medication administration and monitoring guidelines. Pre-procedure, intra-procedure and post-procedure care of the child should be documented in the nursing notes and on the sedation flow record. Post-procedure care of the sedated child should include monitoring according to policy, as well as follow up instructions to the adults with the child. If the child is to be discharged, the adults should be aware of the duration of the sedation and any untoward side effects that may occur. Sedation Analgesia for the pediatric patient should be a safe and effective treatment modality. Knowledge, preparation and clinical competency are key elements in the success of Sedation Analgesia. CONSCIOUS/SEDATION ANALGESIA COMPETENCY ASSESSMENT May be used to add a competency to the self-study module learning. Name________________________________ Title ___________________ (Please Print) I have completed the skills that apply:_______________________ Employee Signature Employee has completed skills: _____________________________ Manager or Educator Signature Method of Observation: E=Exam O=Observation V=Verbal Response R=Return Demo COMPETENCY CHECKLIST Optional to Take to Your Facility . Method of Observation V = Verbal O = Direct Observation E = Test COMPETENCYObservation MethodDATEPreceptor InitialAirway ManagementIdentifies Signs and Symptoms of Impaired Airway.VDemonstrates Use of Manual Resuscitation Bag ODemonstrates use of Pulse Oximeter. VCardiac ManagementA. Identifies normal versus abnormal cardiac rhythmOB. When given a case scenario is able to identify rhythm that warrants calling a code blue.OC. For those that apply, correctly demonstrates use of the defibrillatorOEquipment ManagementA. Verbalizes necessary equipment for ProcedureVB. Demonstrates procedure for attaching electrodes from crash cart monitor.OC. Demonstrates correct placement of pulse oximeterOProcedureA. Verbalizes proper pre-procedure assessmentVB. Verbalizes correct patient assessment parameters.VC. Verbalizes proper sequencing and timing of vital signs during the procedure.VD. Verbalizes proper sequencing and timing of vital signs after the procedure.VE. Given a scenario, correctly utilizes the Aldrete Scoring System.OMedicationsA. Is able to discuss the most commonly used medications during the procedure.VB. When given a scenario, is able to identify the correct reversal agent.OWritten CompetencyA. Completes the post test at 70% competency. Remediated to 100% competency.E Procedure Completed with Competency: _____________________________________ Educator/Preceptor Signature Comments: Remediation if Needed: ReferencesAdapted over many years from various sources including: Sedation and Analgesia Protocol:  HYPERLINK "http://www.wlm-web.com/hcnet/TXFiles/tx009p.pdf" http://www.wlm-web.com/hcnet/TXFiles/tx009p.pdf http://classes.kumc.edu/general/hospital/cseducation/appendixa.htm Chino Valley Medical Center Sedation Analgesia Competency Module Coast Plaza Doctors Hospital Sedation Analgesia Module. East Valley Hospital Medical Center Conscious Sedation Guidelines. Internet Source, Author Chet I. Wyman, M.D. ,Franklin Square Hospital Center,vClinical Instructor, University of Maryland School of Medicine, Baltimore, MD. Copyright Status Some of the information in this packet is in the public domain. Unless stated otherwise, documents and files on NIH web servers can be freely downloaded and reproduced. Most documents are sponsored by the NIH; however, you may encounter documents that were sponsored along with private companies and other organizations. Accordingly, other parties may retain all rights to publish or reproduce these documents or to allow others to do so. Some documents available from this server may be protected under the United States and foreign copyright laws. Permission to reproduce may be required. This is the end of the module: Please complete the evaluation and answer sheet and fax (951) 739-0378 or email to  HYPERLINK "mailto:Educate100@aol.com" Educate100@aol.com Key Medical Resources, Inc.     PAGE  PAGE 2 PAGE  PAGE 3 PAGE  PAGE 17 NOTE: Chloral Hydrate in a total dose of (50mg/kg is considered to be minimally sedating, and anxiolytic, therefore this policy regarding conscious sedation does not apply. 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