ࡱ> %` %wbjbj"x"x @@%o"""""""`D((((\$ &L)<e *&,&,&,&,&,&,&$(h++rP&"   P&""e&""" ""*&" *&""%""% @yձ(!%*&{&0&%,+f".+%+"%TA"l3P&P&" &     ( (6r\"""""" Case study: Lyonel Childs  When he was young, Lyonel Childs was somewhat isolated, even from his two brothers and his sister. He seemed almost suspicious if other children talked to him. He seldom seemed to feel at ease, even with those he had known since nursery. He never smiled or showed much emotion, so that by the time he was 10, even his siblings thought he was peculiar. Adults said he was "nervous." For a few months during his early teens, he was interested in magic and the occult; he read extensively about witchcraft and casting spells. Later he decided he would like to become a minister. He spent long hours in his room learning Bible passages by heart. Lyonel had never been interested much in sex, but at age 24, while studying a mature student, he was attracted to a girl in his poetry class. Mary had blonde hair and dark blue eyes. She always said "Hello" and smiled when they met. He didn't want to betray too great an interest, so he waited until an evening several weeks later to ask her to a New Year's Eve party. She refused him, politely but firmly. As Lyonel mentioned to an interviewer months later, he thought that this seemed strange. During the day Mary was friendly and open with him, but when he ran into her at night, she was reserved. He knew there was a message in this that eluded him, and it made him feel shy and indecisive. He also noticed his thoughts had speeded up so that he couldn't sort them out. "I noticed that my mental energy has lessened," he told the interviewer, "so I went to see the doctor. I told him I had gas forming in my intestines, and I thought it was giving me erections. And my muscles seemed all flabby. He asked me if I used drugs or was feeling depressed. I told him neither one. He game me prescription for some tranquilizers but I just threw them away." Lyonel's skin was pasty white and he was abnormally thin, even for someone so slightly built. He sat quietly without fidgeting during the interview, and his casual clothing seemed quite ordinary. His speech was entirely ordinary; one thought flowed normally into the next, and there were no made-up words. By summer, he had become convinced that Mary was thinking about him. He decided that something must be keeping them apart. Whenever he had this feeling, his thoughts became so "loud" that he felt sure other people must know what he is thinking. He neglected to look for a summer job that year and moved back into his parents' house, where he kept his room, brooding. He wrote long letters to Mary, most of which he destroyed. In the fall, Lyonel realized that his relatives were trying to help him. Although they would wink an eye or tap a finger to let him know when she was near, it did not good. She continued to elude him, sometimes only by minutes. Sometimes there was a ringing in his right ear, which caused him to wonder if he was becoming deaf. His suspicion seemed confirmed by what he privately called "a clear sign." One day while driving he noticed, as if for the first time, the control button for his rear window defroster. It was labeled REAR-DEF which to him meant "right-ear deafness." When winter deepened and the holidays approached, Lyonel knew that he would have to take action. He drove off to Mary's house to have it out with her. As he crossed town, people he passed nodded and winked at him to signal that they understood and approved. A woman's voice, speaking clearly to him from just behind him in the back seat said, "Turn right" and "Atta boy!" Evaluation of Lyonel Childs Lyonel was psychotic. Two of the five symptoms listed above (the "A" symptoms) must be present for a diagnosis of Schizophrenia, and two was the number Lyonel had. His symptoms (hallucinations and delusions) were those that are most often encountered in Schizophrenia. The hallucinations of Schizophrenia are usually auditory. Visual hallucinations often indicate a Substance-Induced Psychotic Disorder or Psychotic Disorder Due to a General Medical Condition; they can also occur in dementia or delerium. Hallucinations of sense or smell are more commonly experienced by a person whose psychosis is due to a medical factor, but they would not rule out Schizophrenia. Like Lyonel's, auditory hallucinations are typically clear and loud; often patients will agree with the examiner who asks, "Is it as loud as my voice is right now?" Although the voices may seem to come from within the patient's head, often they are reported as coming from the hallway, an appliance, or a family pet. The special messages that Lyonel received (finger tapping, eye winking) are called delusions of reference. Patients with Schizophrenia may also experience other sorts of delusions; these have been listed be in the  HYPERLINK "http://www.zacharyodette.com/schizophrenia.shtml" schizophrenia page. Many of these are to some extent persecutory (the patient feels in some way pursued or interfered with). None of Lyonel's delusional ideas were so far from normal experience as to deserve the term bizarre. (If they were, he would need only that one psychotic symptom for the diagnosis of Schizophrenia.) Lyonel did not have disorganized speech, disorganized behavior, or negative symptoms, but other Schizophrenia patients often have these psychotic symptoms. His illness significantly interfered with his work (he didn't get a summer job) and relationships with others (he stayed in his room and brooded). In each of these areas, he functioned much less well than before he became ill. Although Lyonel had heard voices for only a short time, he had been delusional for several months. The prodromal symptoms (his beliefs about internal gas and reduced mental energy) had begun a year or more earlier. He easily fulfilled the requirement of a total duration (prodrome, active symptoms, and residual period) of at least six months. (Many relapses of psychosis occur without appreciable prodromal symptoms. When they do occur, high levels of prodromal symptoms predict high levels of subsequent psychotic symptoms.) The doctor Lyonel consulted found no evidence of a general medical condition. Auditory hallucinations that may exactly mimic the Paranoid Type of Schizophrenia (see below) can occur in Alcohol-Induced Psychotic Disorder. People who are withdrawing from amphetamines may even harm themselves as they attempt to escape terrifying persecutory delusions. Either of these disorders would be suspected if Lyonel had recently used substances. Lyonel also denied feeling depressed. Major Depressive Disorder With Psychotic Features can produce delusions or hallucinations, but often these are mood-congruent (they center about feelings of guilt or deserved punishment). Schizoaffective Disorder could be excluded because he had no prominent mood symptoms (depressive or manic). From the duration of his symptoms, we know that Lyonel could not have Schizophreniform Disorder. The next section presents Lyonel's subtype diagnosis and the course criteria for this diagnosis. Schizophrenia, Paranoid Type Patients with schizophrenia, paranoid type, often appear the most "normal" among schizophrenia patients--despite their obviously psychotic ideas, their behavior and physical appearance remain relatively unaffected. They are usually also better able to take care of their own day-to-day needs, even when they are at their sickest. This relative preservation of social (and, at times, school or work) functioning also sets them quite apart from those with other forms of schizophrenia. These patients have a relatively late age of onset (some studies report) an average of 35 years), whereas most other schizophrenia patients become ill in their 20's. Criteria:  INCLUDEPICTURE "http://www.zacharyodette.com/images/circle.gif" \* MERGEFORMATINET  The patient meets the basic criteria for schizophrenia.  INCLUDEPICTURE "http://www.zacharyodette.com/images/circle.gif" \* MERGEFORMATINET  The patient is preoccupied with delusions or frequent auditory hallucinations.  INCLUDEPICTURE "http://www.zacharyodette.com/images/circle.gif" \* MERGEFORMATINET  None of these symptoms is prominent. - Disorganized speech - Disorganized behavior - Inappropriate or flat affect - Catatonic behavior Further Evaluation of Lyonel Child's In addition to the basic Schizophrenia criteria, a diagnosis of Schizophrenia Paranoid Type, requires the absence of features typical of the Disorganized and Catatonic Types (see below). Paranoid patients do not have speech that is incoherent or affect that is blunted or inappropriate. Lyonel's speech and affect were both typically well preserved. He also had no abnormal or disorganized motor behaviors, which would be typical of the Catatonic Type. As is generally true in the Paranoid Type, Lyonel's hallucinations were related to the topics of his delusions. It is worth noting here that Schizophrenia patients do not necessarily remain true to one subtype or another. A patient may appear Paranoid during one acute episode and subsequently show Disorganized features. Many patients with Schizophrenia also have an abnormal premorbid personality. Often, this takes the form of Schizoid or Schizotypal Personality Disorder. These included constricted affect, no close friends, odd beliefs (interest in the occult), peculiar appearance (as judged by peers), and suspiciousness of other children. Throughout his current episode, Lyonel had had no change of symptoms that might suggest anything other than a continuous course. (Of course, he had no negative symptoms.) All case studies taken from: www.zacharyodette.com/examples.shtml Case study: Bob Naples As his sister told it, Bob Naples was always quiet when he was a kid, but not what you'd call peculiar or strange. Nothing like this had ever happened in their family before. Bob sat in a tiny consulting room down the hall. His lips moved soundlessly, and one bare leg dangled across the arm of his chair. His sole article of clothing was a red-and-white-striped pyjama top. An attendant tried to drape a green sheet across his lap, but he giggled and flung it to the floor. It was hard for his sister, Sharon to say when Bob first began to change. He was never very sociable, even a loner. He hardly ever laughed and always seemed rather distant, almost cold; he never appeared to enjoy anything he did very much. In the five years since he'd finished school, he had lived at their house while he worked in her husband's machine shop, but he never really lived with them. He had never had a girlfriend, or a boyfriend, for that matter, though he sometimes used to talk with a couple of school classmates if they dropped around. About a year and a half ago, Bob had completely stopped going out and wouldn't even return phone calls. When Sharon asked him why, he said he had better do things to do. But all he did when he wasn't working was stay in his room. Sharon's husband had told her that at work, Bob stayed at his lathe during breaks and talked even less than before. "Sometimes Dave would hear Bob giggling to himself. When he'd ask what as funny, Bob would just kind of shrug and just turn away, back to his work." For over a year, things didn't change much. Then, about two months earlier, Bob had started staying up at night. The family would hear him thumping around his room, banging drawers, occasionally throwing things. Sometimes it sounded like he was talking to someone, but his bedroom was on the second floor and he had no phone. He stopped going in to work. "Of course, Dave'd never fire him," Sharon continued." But he was sleepy from being up all night, and he kept nodding off at the lathe. Sometimes he'd just leave it spinning and wander over to stare out the window. Dave was relieved when he stopped coming in. In the last several weeks, all Bob would say was "Gilgamesh." One Sharon asked what it meant and he answered, "It's no red shoe on the backspace." This astonished her so much that she wrote it down. After that, she gave up trying to ask him for explanations. Sharon wasn't sure how Bob got into the hospital. When she'd come home from the supermarket a few hours earlier, he was gone. Then the phone rang and it was the police, saying that they were bringing him in. A security guard down at the precinct had taken him into custody. He was babbling something about Gilgamesh and wearing nothing but a pyjama top. Sharon blotted the corner of her eye with the cuff of her sleeve. "They aren't even his pyjamas, they belong to my daughter." Evaluation of Bob Naples Bob fully met the criteria for Schizophrenia. He had several psychotic symptoms. Besides his badly disorganized speech and behavior, he had the negative symptoms of inappropriate affect and lack of volition (he just stopped going to work). However, even with these typical features it is difficult to rule in the Disorganized Type of Schizophrenia during a first interview, because of the several exclusions that must first be met. Bob would say only one word when he was admitted, so it could not be determined whether he had cognitive deficit, as would be the case in Delirium Due to a General Medical Condition or in a Substance-Induced Psychotic Disorder caused by amphetamines or PCP. Only after treatment was begun might be known for sure. Other evidence of gross brain disease could be sought with skull X-rays, MRI, and blood tests as appropriate. Bipolar I patients can show gross defect of judgment by refusing to remain clothed, but Bob did not have any of the other typical features of mania, such as euphoric mood, hyperactivity, or pressured speech. The absence of prominent mood symptoms would rule out Major Depressive Episode and Schizoaffective Disorder. Over a year earlier, Bob had been found giggling to himself at his lathe, so the early manifestations of Bob's illness had been present for far longer than the six-month minimum for Schizophrenia. This would rule out Schizophreniform Disorder. What about other forms of Schizophrenia? Bob has none of the disorders of motion characteristics of Schizophrenia, Catatonic Type. He did have each of the three symptoms required for a diagnosis of Schizophrenia, Disorganized Type. His affect was inappropriate (he laughed without apparent cause), though reduced lability (termed flat or blunted) would also qualify. By the time of his evaluation, his speech had been reduced to a single word, but earlier it had been incoherent (and peculiar enough that his sister even wrote some of it down). Finally, there was loss of volition (the will to do things): He had stopped going to work and spent most of his time in his room, apparently accomplishing nothing. Of course, his symptoms had been continuous for a longer than a year and included prominent negative symptoms. All case studies taken from: www.zacharyodette.com/examples.shtml Case study: Edward Clapham  Edward Clapham, a 43-year-old, single man, was admitted to the university hospital's mental health service. He gave no chief complaint; he was entirely mute. For the past eight years, he had not communicated by speech or writing. Edward had been previously treated at another hospital but had been transferred for further treatment. He had received neuroleptic medication during his entire hospitalization, though none of these medications had helped him. He reportedly spent the entire day every day lying on his back, toes pointing towards the foot of this bed, fists clenched and turned inward. From years of maintaining this position, he had developed severe muscle contractures at both ankles and both wrists. Most of the time he could be spoon-fed, but occasionally he refused to swallow and had to be fed by nasogastric tube. This had often been the case during the past six months; despite the tube feedings, he had lost about 30 pounds. Very little was known about Edward's background. He had been reared in the Midwest, the second child of a farm family. He may have attended some college, and he had worked for approximately 10 years as tractor salesman. On admission, his mental status examination read as follows: Mr. Clapham lies flat on his back in bed. He is totally mute, so nothing can be learned of his thought content or flow of thought. Similarly, his cognitive processes, insight, and judgment cannot be assessed. His toes point down and his fists are rotated inward. There is a noticeable tremor of his feet and hands; he contracts the muscles of his arms and legs so strongly that they actually shake. Besides being mute, he shows other signs symptoms: When he is approached from one side, he gradually turns his head so that he gazes in the opposite direction. When a limb is placed in any position (for instance, raise high above his head), he will maintain that position for several minutes, even if told that he cannot drop his hand. Any attempt to bend his arm at the elbow, where there are no contractures, is met with resistance. It is evident that the biceps and triceps muscles are contracting together, causing motion at the joint to feel as if one were bending a rod made of wax or some other stiff substance. Every four or five minutes, he wrinkles his nose and purses his lips. This expression lasts for 10 or 15 seconds, then relaxes. There is no apparent purpose to these motions, and they are not accompanied by any motions of the tongue or other indications or tardive dyskinesia. Evaluation of Edward Clapham: Edward fulfilled the generic criteria for Schizophrenia. His illness had lasted far longer than the minimum of six months; it is hard to imagine how it could have had a greater effect on every aspect of his life. Nonetheless, on admission to the mental health unit, he was given as Axis I diagnosis of 298.9 (Psychotic Disorder Not Otherwise Specified). This provisional diagnosis was given because the clinician could not be sure from the initial presentation whether the symptoms were due to the effects of his dehydration and loss of weight (a general medical condition), Schizophrenia, or another cause such as a mood disorder, which is perhaps the most frequent cause of a catatonic syndrome. This list of general medical conditions that can produce catatonic behavior includes liver disease, strokes, epilepsy, and uncommon disorders such as Wilson's disease (a defect of copper metabolism). These possibilities should be vigorously pursued with neurological and medical consultation and with appropriate laboratory and X-ray studies. Urine or blood screens for toxic substances or drugs of abuse should be considered a part of every such patient's workup. Any patient who presents with a first episode of catatonia should probably have an MRI. For patients who have catatonic excitement, mania should be carefully considered. Many patients who have been diagnosed as having Schizophrenia, Catatonic Type, really have a manic phase of Axis I Bipolar Disorder. On the other hand, a patient with severe psychomotor retardation should be considered for a diagnosis of Major Depressive Disorder With Melancholic Features. Although patients with Somatization Disorder are occasionally mute or have abnormalmotor activity, such episodes are usually short-lived, lasting only a few hours or days, not years. Edward's symptoms were classic for Schizophrenia, Catatonic Type. He demonstrated grimacing, muteness, waxy flexibility, and catalepsy. He could not be called stuporous because he was alert enough to turn away from approaching stimulus (negativism). His behavior did not include enough range to show other typical catatonic behaviors. After a careful review of the options, Edward was given a course of electroconvulsive therapy (ECT). Although the first three bilateral ECT sessions produced no noticeable effect, after the fourth he asked for a glass of water. After a total of 10 sessions, he was conversing with others on the ward, feeding himself, and walking always on tiptoe because of the severe contractures at his ankles. Although he continued to show residual symptoms of his disease, he lost all of his catatonic symptoms and eventually left the hospital, whereupon he was lost to follow-up. All case studies taken from: www.zacharyodette.com/examples.shtml Case study: Natasha Oblamov Natasha was an artist. She specialized in oil-on-canvas copies of the photographs she took of the countryside near her home. Although she had had a one-woman exhibition in a local art gallery two years earlier, she still had never earned a dollar from her art work. She had a room in her father's apartment, where the two lived on his retirement income. Her brother lived on a back ward of the state mental hospital. The signs had first been there about 10 months ago, when Natasha stopped attending class at the art institute and gave up her two or three drawing pupils. Mostly she stayed in her room, even at mealtimes; she spent much of her time sketching. Her father brought Natasha for evaluation because she kept opening the door. Perhaps six weeks earlier she had begun emerging from her room several times each evening, standing uncertainly in the hallway for several moments, then opening the front door. After peering up and down the hallway, she would retreat to her own room. In the past week, she had reenacted this ritual a dozen times each evening. Once or twice, her father thought he heard her mutter something about "Jason." When he asked her who Jason was, she only looked blank, and turned away. Natasha was a slender woman with a round face and watery blue eyes that never seemed to focus. Although she volunteered almost nothing, she answered every question clearly and logically, if briefly. She was fully oriented and had no suicidal ideas or other problems with impulse control. Her affect was as flat as one of her canvases. She would describe her most frightening experiences with no more emotion than if she was making a bed. Jason was an instructor at the art institute. Some months earlier, one afternoon when her father was out, he had come to the apartment to help her with "some special stroking techniques," as she put it (referring to her brush). Although they had ended up naked together on the kitchen floor, she had spent most of the time explaining why she felt she should put her clothes back on. He left unrequited, and she never returned to the art institute. Not long afterward, Natasha "realized" that Jason was hanging about, trying to see her again. She would sense his presence just outside her door, but each time she opened it, he vanished. This puzzled her, but she couldn't say that she felt depressed, angry, or anxious. Within a few weeks she started to hear a voice quite a bit like Jason's, which seemed to be speaking to her from the photographic enlarger she had set up in the tiny second bathroom. "It usually just said the 'C' word," she explained in response to a question. "The 'C' word?" "You know, the place on a woman's body where you do the 'F' word." Unblinking and calm, Natasha sat with her hands folded in her lap. Several times in the past several weeks, Jason had slipped through her window at night and climbed into her bed while she slept. She had awakened to feel the pressure of his body on hers; it was especially intense in her groin area. By the time she had fully awakened, he would be gone. The previous week when she went in to use the bathroom, the head of an eel, or perhaps it was a large snake, emerged from the toilet bowl and lunged at her. She lowered the lid on the animal's neck and it disappeared. Since then, she had only used the toilet in the hall bathroom. Evaluation of Natasha Oblamov Natasha had a variety of psychotic symptoms. They included hallucinations (visual in this case--the eel in the toilet) and a non-bizarre delusions about Jason. She also had the negative symptom of flat affect (she talked about eels in her toilet without showing any emotion at all). Although her active symptoms had been evident for only a few months, the prodromal symptom of staying in her room had been present for about 10 months. Her disorder obviously interfered with her ability to complete a canvas, though she did not suffer from lack of volition. Nothing in Natasha's history would suggest a general medical condition. However, a certain amount of time of routine lab testing might be ordered initially: complete blood count, routine blood chemistries, urinalysis. No evidence is given in the vignette to suggest that she had a Substance-Induced Psychotic Disorder, and her affect, though flat, was pleasant and nothing like the severely depressed mood of Major Depressive Disorder With Psychotic Features. Furthermore, she had never had suicidal ideas. There was nothing to suggest that she had ever had a Manic Episode. The gradual onset of illness that persisted for longer than six months would rule out Schizophreniform Disorder and Brief Psychotic Disorder. Finally, her brother had Schizophrenia. About 10% of the first-degree relatives (parents, siblings, children) of patients with Schizophrenia also develop this condition. The subtype of Natasha's disease is easily settled. She had no motor symptoms that would qualify her for a diagnosis of Catatonic Type; her flat affect would rule out Paranoid Type. Her affect suggested Disorganized Type, but she did not have the other symptoms (disorganization of speech and behavior) for this diagnosis. By the process of elimination, then, she had Undifferentiated Type, Continuous. Although she not fulfill the criteria for Disorganized Type, she did have fairly prominent flat affect; the clinician who interviewed Natasha added a specifier to her diagnosis to reflect this symptom. Other might not. All case studies taken from: www.zacharyodette.com/examples.shtml Case Study: Ramona Kelt When she was 20 and had been married only a few months, Ramona Kelt was hospitalized for the first time. According to records, her mood had been silly and inappropriate, her speech disjointed and hard to follow. She had been admitted after putting coffee grounds and orange peels on her head. She talked about television cameras in her closet that spied upon her whenever she had sex. Since then she had several additional episodes, widely scattered across 25 years. Whenever she fell ill, her symptoms were the same. Each time she recovered enough to return home to her husband. Every morning Ramon's husband had to prepare a list that spelled out her day's activities, even including meal planning and cooking. Without it, he might arrive home to find that she had accomplished nothing that day. The couple had no children and few friends. Ramona's most recent evaluation was prompted by a change in medical care plans. Her new clinician noted that she was still taking neuroleptics; each morning her husband carefully counted them out onto her plate and watched her swallow them. During the interview she winked and smiled when it did not seem appropriate. She said that it had been several years since television cameras had bothered her, but she wondered whether her closet "might be haunted." Evaluation of Ramona Kelt Although the information contained in the vignette is sketchy, there is enough to support a strong presumption of Schizophrenia. Ramona had been ill for many years with symptoms that included disorganized behavior and a delusion about television cameras. Early on she had been diagnosed as Disorganized Type (hebephrenic) would seem warranted from her inappropriate affect and her bizarre speech and behavior. However, she did not now meet the basic criteria for Schizophrenia. Between episodes (during the most recent interview), she continued to show peculiarities or affect (winking) and ideation (the closet might be haunted) that suggested attenuated psychotic symptoms. She also has a serious negative symptom, avolition: If her husband didn't plan her day for her, she would accomplish nothing. Of course, to have any type of Schizophrenia, Ramona would have to have none of the exclusions (general medical conditions, Substance-Induced Psychotic Disorder, mood disorders, Schizoaffective Disorder). 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