ࡱ> ~}@ #jbjbܡܡ W_l$$$$8\p$u!2!4!4!4!4!4!4!,# 5%`!K@`!|2!""2!y! }_$$ !u!u! %%!3c[iv]: 20th Century: Human Genome Student Resource Sheet 2a: Genetically Good Enough Person? Activity One 4 minutes Cut out the ten descriptions [Student Resource Sheet 2b] of qualities that may have a genetic component, and then discard one of these. On your own, sort them into a diamond shape with the one quality you think you would most like in a human being down to the one you would least like with two cards on the second row and three on the third row. This will make a diamond pattern like the one below. As you do this think about the reasons you have for why you choose to put each card where you do.  Most strongly agree with agree with agree with No strong view No strong view No strong view disagree with disagree with Strongly disagree Activity Two 10 minutes Get together with two or three other people. Do the same activity again as a group. Try to agree a diamond pattern between the whole group. You will find that you disagree over the order that the cards should go in. Listen carefully to each others reasons for the order they believe in and try and find out why people think what they do. Listening to each others reasons is as important as agreeing on the pattern of cards in the diamond. As you listen to each other try and work out what other people believe about whether there is an ideal human being, whether certain qualities should be eliminated, whether we have a right to interfere, what makes someone really human and how religious views are affecting their decision? As you listen you may find the order you want to put the cards in changes. Activity Three 6 Minutes On your own think back over your discussion and answer the following questions. Do you think society/ individual parents should select positively for any of these qualities in the babies they allow to be born? If so, which ones? Why? Do you think society/ individual parents should seek to eliminate any of these qualities in the babies they allow to be born? Why? What are the implications of taking the course of action you suggest for the way people define what a person is and what their worth is? How would the religious view (or none) of an individual affect their view of the rights and wrongs of selecting traits in their offspring? Helpful information Whether a person will have blue eyes, cystic fibrosis or haemophilia is determined by their genetic information. The other qualities listed may have a genetic element or component but are not solely determined by genetic information. Environmental and choice factors play a much bigger role in these qualities. Cystic Fibrosis: Cystic Fibrosis is the UK's most common life-threatening, inherited disease and affects more than 7500 babies, children and young adults. It affects a number of organs in the body (especially the lungs and pancreas) by clogging them with thick, sticky mucus. Symptoms can include poor weight gain, coughs and repeated chest infections. At present there is no cure for CF. Until the 1930s, the life expectancy of a baby with CF was only a few months. Today the average life expectancy for someone with CF is around 31 years. (Information taken from the cystic fibrosis trust website.) Parkinsons: Parkinson's disease (PD) is a common neurological disorder which affects 1-2% of the elderly in the UK. The disease starts slowly and gradually and the symptoms include muscle tremor, stiffness, or clumsiness, usually involving one side. Sufferers have difficulty walking, fatigue, depression, or limb discomfort. The person may have a blank, mask-like facial expression, a reduction in the spontaneous blink rate, and a soft monotonous voice. As walking becomes more difficult the person may shuffle and fall. The resting tremor of Parkinson's is present in 70-80% of cases. It is worsened by stress, and generally decreases or disappears with action. Drugs can be used to control some of the symptoms of the disease but there is currently no cure. A gene linked to Parkinsons disease has been identified on chromosome 4. (information from the Parkinsons disease website and the Department of Clinical Neurosciences website). Schizophrenia A person suffering from Schizophrenia has distortions of thinking and perception. They may not have a clear sense of their own individuality so that they believe that their private thoughts are known by others or that supernatural forces are influencing their actions in ways that are often bizarre. The individual may be unaware that there is anything wrong with his or her mental state. Common problems include hearing voices, strange beliefs, problems concentrating, coping with daily activities, social interactions, work or studies. No single factor causes schizophrenia, but several factors contribute to the condition. A person's genetic make-up is important in that it may make a person more likely to develop schizophrenia. This makes a person more vulnerable to stresses in life than is usual. Stresses that can have an impact include severe infections, drugs, painful life events such as bereavement, major life changes, overcrowding or homelessness or a family environment where there is poor communication. About 1 in 100 people are believed to suffer from schizophrenia at some point in their life. In families where one member has schizophrenia then other family members are ten times more likely to suffer from it than the general population. Further evidence for a genetic link comes from the findings that the identical twin of a person with schizophrenia is much more likely to develop schizophrenia than a non-identical twin. (Information taken from the NHS electronic library for Health) Haemophilia Haemophilia is a blood condition in which an essential clotting factor is either partly or completely missing. This causes a person with haemophilia to bleed for longer than normal. Cuts and grazes are not great problems as a little pressure and a plaster are usually enough to stop bleeding. The main problem is internal bleeding into joints, muscles and soft tissues. If left untreated these bleeds cause acute pain and severe joint damage leading to disability. Bleeding episodes have in the past caused difficulties with education and employment, as well as mobility problems for many who have been crippled by the effects of regular bleeding into joints. Haemophilia is a lifelong inherited genetic condition, which affects females as carriers and males who inherit the condition. Treatment for haemophilia is usually by injections to provide replacement of the missing clotting factor. There is no permanent way of replacing or increasing the clotting factor level. Before 1986, much of the clotting factor derived from donated blood had been contaminated. The haemophilia community in the UK has been severely affected by contamination of blood products leading to widespread infection of HIV and Hepatitis C. Approximately 1,200 people have been infected with HIV. More than 4,800 people have been infected with Hepatitis C. This disease affects the functioning of the liver. Nobody with haemophilia has contracted HIV or Hepatitis C from blood products since 1986 as heat treated and recombinant products now prevent contamination. (Information taken from the website of the Haemophilia society.) 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