ࡱ> RVQ 7bjbj 4.xx 1 -----AAA8y4<A{:>(: : : : : : :<[? :- :--5:F--::$24p&o@AF^2 :K:0{: 3oAoA444noA-4 : :{:oA : Possible Side Effects of FOLFIRINOX (Leucovorin, 5-Fluorouracil, Irinotecan, and Oxaliplatin) (Table Version Date: November 14, 2016) COMMON, SOME MAY BE SERIOUS In 100 people receiving FOLFIRINOX (Leucovorin, 5-Fluorouracil, Irinotecan, and Oxaliplatin), more than 20 and up to 100 may have:Hair loss Redness, pain or peeling of palms and soles Rash, increased risk of sunburn, itching Severe diarrhea, nausea, vomiting, constipation, loss of appetite, weight loss Difficulty swallowing Sores in mouth Heartburn Infection, especially when white blood cell count is low Anemia which may require a blood transfusion Bruising, bleeding Headache Tiredness, weakness, dizziness Numbness, tingling or pain, "pins and needles" of the hands, feet, arms and legs Tingling or a loss of feeling in your hands, feet, nose, or tightness in throat or jaw, or difficulty swallowing or breathing which may be made worse by exposure to cold Cough, shortness of breath Fever, pain OCCASIONAL, SOME MAY BE SERIOUS In 100 people receiving FOLFIRINOX (Leucovorin, 5-Fluorouracil, Irinotecan, and Oxaliplatin), from 4 to 20 may have:Chest pain Abnormal heartbeat which may cause fainting Swelling and redness at the site of the medication injection Hives Skin changes Weight gain, belly pain Internal bleeding which may cause black tarry stool, blood in vomit or urine, or coughing up blood Changes in taste Blood clot which may cause swelling, pain, shortness of breath Bleeding from multiple sites including vaginal bleeding, bleeding of the testis, or bleeding of the brain Liver damage which may cause yellowing of eyes and skin Allergic reaction which may cause rash, low blood pressure, wheezing, shortness of breath, swelling of the face or throat Change in voice Confusion Inability to move shoulder or turn head Blurred vision, watering eyes Discomfort from light Abnormal body movement including the eye and eyelid Difficulty walking, using your hands, opening mouth, talking, with balance and hearing, smelling, eating, sleeping, emptying the bladder Hearing loss Swelling of the body which may cause shortness of breath Kidney damage which may require dialysis Scarring of the lungs Blockage of the airway which may cause shortness of breath, cough, wheezing Dehydration RARE, AND SERIOUS In 100 people receiving FOLFIRINOX (Leucovorin, 5-Fluorouracil, Irinotecan, and Oxaliplatin), 3 or fewer may have:Damage to the heart which may cause shortness of breath A new cancer resulting from treatment of a prior cancer Redness, pain or peeling of palms and soles     Page  PAGE 1 of  NUMPAGES 2 #%1AQ^mr{~  $ ;͎~o`QBh]=hH PCJOJQJaJh]=hZoCJOJQJaJh]=hi7CJOJQJaJhtI?htI?CJOJQJaJh]=hH5CJOJQJaJh]=h0Jh]=hzd_CJOJQJaJh|/CJOJQJaJh(UCJOJQJaJh]=h(UCJOJQJaJh]=h}eCJOJQJaJ h]=hb' h]=hIFhURmH sH  h]=hi7 h]=h}e^ % & 0 \ nVVVV$ & FL$If^`La$gdaskd$$Ifl44T*) t0644 la f4p ytq $$Ifa$gdg^gdIF^gdIN $ % & D E F ѶћsdUF7dh]=htI?CJOJQJaJhtI?htI?CJOJQJaJh]=huCJOJQJaJh]=h}eCJOJQJaJh]=hH5CJOJQJaJh]=h0Jh]=h-)CJOJQJaJh]=hG;CJOJQJaJhCJOJQJaJhhCJOJQJaJh]&CJOJQJaJh]=haCJOJQJaJh]=hQCJOJQJaJh]=haJh]=hdCJOJQJaJh]=h|L,CJOJQJaJh>lCJOJQJaJh]=hi7CJOJQJaJhdCJOJQJaJhdhdCJOJQJaJh]=hQCJOJQJaJh]=haJh97h8hxrh8CJaJhxrh8CJOJQJaJ$h-Z*5CJOJQJaJmHnHu(jhxrh85CJOJQJUaJhxrh85CJOJQJaJ21:pQ/ =!"#$%` $$If !vh5)#v):V l44 t065)a f4p ytq $$If !vh5)#v):V l t065)a ytg$$If !vh5)#v):V l44 t065)a f4p ytq $$If !vh5)#v):V l t065)a ytg$$If !vh5)#v):V l44 t065)a f4p ytq $$If !vh5)#v):V l t065)a ytgj  666666666vvvvvvvvv66666>666666666666666666666666666666666666666666666666hH666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ OJPJQJ_HmH nH sH tH J`J VNormal$a$OJPJQJ_HmH sH tH N`N }e Heading 1@&CJOJQJaJmHsHtHDA D Default Paragraph FontRi@R 0 Table Normal4 l4a (k ( 0No List :) : V Page Number CJOJQJ@ @ VHeader ! mHsHtHF/F V Header CharCJOJPJQJ^JaJ@ `"@ V0Footer ! mHsHtHF/1F V0 Footer CharCJOJPJQJ^JaJR^@BR V Normal (Web)dd[$\$a$ CJOJQJRRR V List Paragraph ^a$m$CJOJQJaJjcj Q Table Grid7:V0P rP Q0 Balloon TextCJOJQJaJmHsHtHR/R Q0Balloon Text CharCJOJPJQJ^JaJB' B 10Comment ReferenceCJaJ@ @ 10 Comment Text mHsHtHR/R 10Comment Text CharCJOJPJQJ^JaJ@j @ 10Comment Subject5\^/^ 10Comment Subject Char5CJOJPJQJ\^JaJH/H }eHeading 1 CharCJOJPJQJaJ8W`8 2!5`Strong5CJOJQJaJPK![Content_Types].xmlj0Eжr(΢Iw},-j4 wP-t#bΙ{UTU^hd}㨫)*1P' ^W0)T9<l#$yi};~@(Hu* Dנz/0ǰ $ X3aZ,D0j~3߶b~i>3\`?/[G\!-Rk.sԻ..a濭?PK!֧6 _rels/.relsj0 }Q%v/C/}(h"O = C?hv=Ʌ%[xp{۵_Pѣ<1H0ORBdJE4b$q_6LR7`0̞O,En7Lib/SeеPK!kytheme/theme/themeManager.xml M @}w7c(EbˮCAǠҟ7՛K Y, e.|,H,lxɴIsQ}#Ր ֵ+!,^$j=GW)E+& 8PK!Ptheme/theme/theme1.xmlYOo6w toc'vuر-MniP@I}úama[إ4:lЯGRX^6؊>$ !)O^rC$y@/yH*񄴽)޵߻UDb`}"qۋJחX^)I`nEp)liV[]1M<OP6r=zgbIguSebORD۫qu gZo~ٺlAplxpT0+[}`jzAV2Fi@qv֬5\|ʜ̭NleXdsjcs7f W+Ն7`g ȘJj|h(KD- dXiJ؇(x$( :;˹! I_TS 1?E??ZBΪmU/?~xY'y5g&΋/ɋ>GMGeD3Vq%'#q$8K)fw9:ĵ x}rxwr:\TZaG*y8IjbRc|XŻǿI u3KGnD1NIBs RuK>V.EL+M2#'fi ~V vl{u8zH *:(W☕ ~JTe\O*tHGHY}KNP*ݾ˦TѼ9/#A7qZ$*c?qUnwN%Oi4 =3ڗP 1Pm \\9Mؓ2aD];Yt\[x]}Wr|]g- eW )6-rCSj id DЇAΜIqbJ#x꺃 6k#ASh&ʌt(Q%p%m&]caSl=X\P1Mh9MVdDAaVB[݈fJíP|8 քAV^f Hn- "d>znNJ ة>b&2vKyϼD:,AGm\nziÙ.uχYC6OMf3or$5NHT[XF64T,ќM0E)`#5XY`פ;%1U٥m;R>QD DcpU'&LE/pm%]8firS4d 7y\`JnίI R3U~7+׸#m qBiDi*L69mY&iHE=(K&N!V.KeLDĕ{D vEꦚdeNƟe(MN9ߜR6&3(a/DUz<{ˊYȳV)9Z[4^n5!J?Q3eBoCM m<.vpIYfZY_p[=al-Y}Nc͙ŋ4vfavl'SA8|*u{-ߟ0%M07%<ҍPK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 +_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!Ptheme/theme/theme1.xmlPK-! ѐ' theme/theme/_rels/themeManager.xml.relsPK] 7 . 0003$ F EQ7  ^ 7 +-3!L# @0(  B S  ?      5 8 ]       $ 5 8 #AQm{&EFG_ O P Q g     $ 3 8  dt~u 8[rx6K€ 1%QM+QDRkXpR.Xjt=6QyxxT ^`OJQJo(^`OJQJ^Jo(o p^p`OJQJo( @ ^@ `OJQJo(^`OJQJ^Jo(o ^`OJQJo( ^`OJQJo(^`OJQJ^Jo(o P^P`OJQJo( ^`OJQJo(^`OJQJ^Jo(o p^p`OJQJo( @ ^@ `OJQJo(^`OJQJ^Jo(o ^`OJQJo( ^`OJQJo(^`OJQJ^Jo(o P^P`OJQJo( ^`OJQJo(^`OJQJ^Jo(o p^p`OJQJo( @ ^@ `OJQJo(^`OJQJ^Jo(o ^`OJQJo( ^`OJQJo(^`OJQJ^Jo(o P^P`OJQJo( ^`OJQJo(^`OJQJ^Jo(o p^p`OJQJo( @ ^@ `OJQJo(^`OJQJ^Jo(o ^`OJQJo( ^`OJQJo(^`OJQJ^Jo(o P^P`OJQJo( ^`OJQJo(^`OJQJ^Jo(o pp^p`OJQJo( @ @ ^@ `OJQJo(^`OJQJ^Jo(o ^`OJQJo( ^`OJQJo(^`OJQJ^Jo(o PP^P`OJQJo( ^`OJQJo(^`OJQJ^Jo(o p^p`OJQJo( @ ^@ `OJQJo(^`OJQJ^Jo(o ^`OJQJo( ^`OJQJo(^`OJQJ^Jo(o P^P`OJQJo( ^`OJQJo(^`OJQJ^Jo(o p^p`OJQJo( @ ^@ `OJQJo(^`OJQJ^Jo(o ^`OJQJo( ^`OJQJo(^`OJQJ^Jo(o P^P`OJQJo( ^`OJQJo(^`OJQJ^Jo(o p^p`OJQJo( @ ^@ `OJQJo(^`OJQJ^Jo(o ^`OJQJo( ^`OJQJo(^`OJQJ^Jo(o P^P`OJQJo( |^`|OJQJo(^`OJQJ^Jo(o p^p`OJQJo( @ ^@ `OJQJo(^`OJQJ^Jo(o ^`OJQJo( ^`OJQJo(^`OJQJ^Jo(o P^P`OJQJo( ^`OJQJo(^`OJQJ^Jo(o p^p`OJQJo( @ ^@ `OJQJo(^`OJQJ^Jo(o ^`OJQJo( ^`OJQJo(^`OJQJ^Jo(o P^P`OJQJo( 1%Qtu rdRR.X+QQy6K                                                                         g                 5tQW1dM$>`L*Z3E>|IFWuB0Oa9oU  q z ! fM x {  <O))bd>kw W J-^BSbg`W7y{7^p* * `; y <!gtI?y?k@p@W(AB[0C`2CCC1EFGFI"J?GKMiNOH PiQHRPR]RSSl0S;`S;/T&U/UUXlfYK)Z&[#l]{i^i^zd_t_&3`eaEma;Zc= d"de ee}evf@[ghii;j#lll4l>l@l$mw.mnOnUn"dnoo#oZo xd}XI|/Z59zzl!)3=KE~=4xpd[ wG{clVZTf%6?HNzgs ,41fQzP <1IF9+Dhi-J RMKU5]&KWzR-'$xfjDnVeZ Jb'I~ Y`\IN-E/`  @7 x@Unknown G*Ax Times New Roman5Symbol3. *Cx Arial7.@Calibri[BookmanBookman Old Style5. .[`)Tahoma?= *Cx Courier New;WingdingsA$BCambria Math" hsK'nK "_;;_;;!r0  3qHP  $PV2!xxIPossible Side Effects of FOLFOX (Leucovorin, 5-Fluorouracil, Oxaliplatin)IPossible Side Effects of FOLFOX (Leucovorin, 5-Fluorouracil, Oxaliplatin)MPossible Side Effects, FOLFOX (Leucovorin, 5-Fluorouracil, Oxaliplatin), 5-FU HHS/DCTD/CTEP Jean Zhao4         Oh+'0T@X     (4<DLLPossible Side Effects of FOLFOX (Leucovorin, 5-Fluorouracil, Oxaliplatin)LPossible Side Effects of FOLFOX (Leucovorin, 5-Fluorouracil, Oxaliplatin)HHS/DCTD/CTEPPPossible Side Effects, FOLFOX (Leucovorin, 5-Fluorouracil, Oxaliplatin), 5-FU Normal.dotm Jean Zhao13Microsoft Office Word@L@FoU@n>@DO@_՜.+,D՜.+,L px  . Document;;  JPossible Side Effects of FOLFOX (Leucovorin, 5-Fluorouracil, Oxaliplatin) TitleP 5= LanguageEnglish !"#$%&'()*+,-./0123456789:;<=>?@BCDEFGHJKLMNOPSTUcXYZ[\]^_`abRoot Entry FPf4o@WData 1Table AWordDocument4.SummaryInformation(ADocumentSummaryInformation8IMsoDataStore o@p&o@CFEWXIQQRY3==2o@#o@Item  Properties7m5IUROO50FGB==2 o@p&o@Item  EPropertiesIO004VNEJBHMVRA==2o@p&o@Item OPropertiesSU  !"#$%&'()*+,-./012345689:;<=>?@ABCDFGHJKLMNPQRTUVWXZ This value indicates the number of saves or revisions. The application is responsible for updating this value after each revision. DocumentLibraryFormDocumentLibraryFormDocumentLibraryForm   F'Microsoft Office Word 97-2003 Document MSWordDocWord.Document.89qCompObjYy