ࡱ> ] 5bjbjjj 7")b)b:C &&&&&:::8rT:RJRRhhhC.q iHkHkHkHkHkHkH$LNH}&-CC--H&&hh JCCC-b &h&hiHC-iHCCChfy/9CUH"J0RJCPO<POCC&PO&-C(&!dC&).HH @RJ----PO B : Curriculum Vitae Timothy R. Hoover Contact Information current address: Department of Microbiology University of Georgia Athens, Georgia 30602 phone number (706) 542-2675 FAX number (706) 542-2674 e-mail address trhoover@uga.edu Education B.A. (Biology), 1978-1982, graduated magna cum laude, Susquehanna University, Selinsgrove, PA Ph.D. (Biochemistry), 1982-1988, University of Wisconsin-Madison (research advisor, Paul W. Ludden) post-doctoral fellow, 1988-1991, University of California at Berkeley (research advisor, Sydney G. Kustu) Awards Proctor & Gamble Fellowship, Department of Biochemistry, University of Wisconsin, 1984-1985 Post-doctoral Fellowship from the Burroughs-Wellcome Fund, Life Sciences Research Foundation, Baltimore, Maryland, 1989-1991 Faculty Undergraduate Advisor Award, 2007 CURO Excellence in Undergraduate Research Mentoring Award, Master Level Faculty Award, 2007 Positions Held Head, 2012-present, Department of Microbiology, University of Georgia Professor, 2010-present, Department of Microbiology, University of Georgia Associate Head, 2001-2012, Department of Microbiology, University of Georgia Undergraduate Coordinator, 1998-2012, Department of Microbiology, University of Georgia Associate Professor, 1998-2010, Department of Microbiology, University of Georgia Assistant Professor, 1991-1998, Department of Microbiology, University of Georgia Post-doctoral Associate, 1988-91, Department of Microbiology and Immunology, and Department of Plant Pathology, University of California at Berkeley Research Assistant, 1982-88, Department of Biochemistry, University of Wisconsin Bibliography I. Research articles 1. Hoover, T. R. and P. W. Ludden. 1984. Derepression of nitrogenase by addition of malate to cultures of Rhodospirillum rubrum grown with glutamate as the carbon and nitrogen source. J. Bacteriol. 159: 400-403. 2. Hoover, T. R., V. K. Shah, G. P. Roberts, and P. W. Ludden. 1986. NifV-dependent, low-molecular-weight factor required for in vitro synthesis of the iron-molybdenum cofactor of nitrogenase. J. Bacteriol. 167: 999-1003. 3. Hoover, T. R., A. D. Robertson, R. L. Cerny, R. N. Hayes, J. Imperial, V. K. Shah, and P. W. Ludden. 1987. Identification of the V factor needed for synthesis of the iron-molybdenum cofactor of nitrogenase as homocitrate. Nature (London) 329: 855-857. 4. Hoover, T. R., J. Imperial, P. W. Ludden, and V. K. Shah. 1988. Homocitrate cures the NifV- phenotype in Klebsiella pneumoniae. J. Bacteriol. 170: 1978-1979. 5. Hoover, T. R., J. Imperial, J. Liang, P. W. Ludden, and V. K. Shah. 1988. Dinitrogenase with altered substrate specificity results from the use of homocitrate analogues for in vitro synthesis of the iron-molybdenum cofactor. Biochemistry 27: 3647-3652. 6. Hoover, T. R., J. Imperial, P. W. Ludden, and V. K. Shah. 1989. Homocitrate is a component of the iron-molybdenum cofactor of nitrogenase. Biochemistry 28: 2768-2771. 7. Imperial, J., T. R. Hoover, M. S. Madden, P. W. Ludden, and V. K. Shah. 1989. Substrate reduction properties of dinitrogenase activated in vitro are dependent upon the presence of homocitrate or its analogues during iron-molybdenum cofactor synthesis. Biochemistry 28: 7796-7799. 8. Santero, E., T. Hoover, J. Keener, and S. Kustu. 1989. In vitro activity of the nitrogen fixation regulatory protein NIFA. Proc. Natl. Acad. Sci. USA 86: 7346-7350. 9. Hoover, T. R., E. Santero, S. Porter, and S. Kustu. 1990. The integration host factor stimulates interaction of RNA polymerase with NIFA, the transcriptional activator for nitrogen fixation operons. Cell 63: 11-22. 10. Santero, E., T. R. Hoover, A. K. North, D. K. Berger, S. Porter, and S. Kustu. 1992. Role of integration host factor in stimulating transcription from the s54-dependent nifH promoter. J. Mol. Biol. 227: 602-620. 11. Gu, B., J. H. Lee, T. R. Hoover, D. Scholl, and B. T. Nixon. 1994. Rhizobium meliloti DctD, a s54-dependent transcriptional activator, may be negatively controlled by a subdomain in the C-terminal end of its two-component receiver module. Mol. Microbiol. 13: 51-66. 12. Lee, J. H., D. Scholl, B. T. Nixon, and T. R. Hoover. 1994. Constitutive ATP hydrolysis and transcription activation by a stable, truncated form of Rhizobium meliloti DCTD, a s54-dependent transcriptional activator. J. Biol. Chem. 269: 20401-20409. 13. Lee, J. H. and T. R. Hoover. 1995. Protein crosslinking studies suggest that Rhizobium meliloti C4-dicarboxylic acid transport protein D, a s54-dependent transcriptional activator, interacts with s54 and b subunits of RNA polymerase. Proc. Natl. Acad. Sci. USA 92: 9702-9706. 14. Ashraf, S., M. Kelly, Y.-K. Wang, and T. R. Hoover. 1997. Genetic analysis of the Rhizobium meliloti nifH promoter, using the P22 challenge phage system. J. Bacteriol. 179: 2356-2362. 15. Wang, Y.-K. and T. R. Hoover. 1997. Alterations within the activation domain of the s54-dependent activator DctD that prevent transcriptional activation. J. Bacteriol. 179: 5812-5819. 16. Wang, Y.-K., J. H. Lee, J. M. Brewer, and T. R. Hoover. 1997. A conserved region in the s54-dependent activator DctD is involved in both binding to RNA polymerase and coupling ATP hydrolysis to activation. Mol. Microbiol. 26: 373-386. 17. Gao, Y., Y.-K. Wang, and T. R. Hoover. 1998. Mutational analysis of the phosphate-binding loop of Rhizobium meliloti DctD, a s54-dependent activator. J. Bacteriol. 180: 2792-2795 18. Leary, B. A., N. Ward-Rainey, and T. R. Hoover. 1998. Cloning and characterization of Planctomyces limnophilus rpoN: complementation of a Salmonella typhimurium rpoN mutant strain. Gene 221: 151-157. 19. Kelly, M. T. and T. R. Hoover. 1999. Mutant forms of Salmonella typhimurium s54 defective in transcription initiation but not promoter binding activity. J. Bacteriol. 181: 3351-3357. 20. Sojda, J., III, B. Gu, J. Lee, T. R. Hoover, and B. T. Nixon. 1999. A rhizobial homolog of IHF stimulates transcription of dctA in Rhizobium leguminosarum but not in Sinorhizobium meliloti. Gene 238: 489-500. 21. Kelly, M. T. and T. R. Hoover. 2000. The amino-terminus of Salmonella enterica serovar typhimurium s54 is required for interaction with an enhancer-binding protein and binding to fork junction DNA. J. Bacteriol. 182: 513-517. *22. Kelly, M. T., ! J. A. Ferguson, III, and T. R. Hoover. 2000. Transcription initiation-defective forms of s54 that differ in activity from a heteroduplex DNA template. J. Bacteriol. 182: 6503-6508. 23. Bundy, B. M., L. S. Collier, T. R. Hoover, and E. L. Neidle. 2002. Synergistic transcriptional activation by a single regulatory protein in response to two distinct metabolites. Proc. Natl. Acad. Sci. USA 99: 7693-7698. 24. Wang, Y.-K., S. Park, B. T. Nixon, and T. R. Hoover. 2003. Nucleotide-dependent conformational changes in the s54-dependent activator DctD. J. Bacteriol. 185: 6503-6508. 25. Xu, H., B. Gu, B. T. Nixon, and T. R. Hoover. 2004. Purification and characterization of the AAA+ domain of Sinorhizobium meliloti DctD a s54-dependent activator. J. Bacteriol. 186: 3499-3507. 26. Brahmachary, P., M. Dashti, J. Olson, and T. R. Hoover. 2004. Helicobacter pylori FlgR is an enhancer-independent activator of s54-RNA polymerase holoenzyme. J. Bacteriol. 186: 4535-4542. *27. Xu, H., M. T. Kelly, B. T. Nixon, and T. R. Hoover. 2004. Novel substitutions in the s54-dependent activator DctD that increase dependence on upstream activation sequences or uncouple ATP hydrolysis from transcriptional activation. Mol. Microbiol. 54: 32-44. 28. Pereira, L. and T. R. Hoover. 2005. Stable accumulation of s54 in Helicobacter pylori requires the novel protein HP0958. J. Bacteriol. 187: 4463-4469. 29. Pereira, L., P. Brahmachary, and T. R. Hoover. 2006. Characterization of Helicobacter pylori s54 promoter-binding activity. FEMS Microbiol. Lett. 259: 20-26. 30. De Carlo, S., B. Chen, T. R. Hoover, E. Kondrashkina, E. Nogales, and B. T. Nixon. 2006. The structural basis for regulated assembly and function of the transcriptional activator NtrC. Genes & Dev. 20: 1485-1495. 31. Badger, J. H., T. R. Hoover, Y. V. Brun, R. M. Weiner, M. T. Laub, G. Alexandre, J. Mrzek, Q. Ren, I. T. Paulsen, K. E. Nelson, H. M. Khouri, D. Radune, J. Sosa, R. J. Dodson, S. A. Sullivan, M. J. Rosovitz, R. Madupu, L. M. Brinkac, A. S. Durkin, S. C. Daugherty, S. P. Kothari, M. G. Giglio, L. Zhou, D. H. Haft, J. D. Selengut, T. M. Davidsen, Q. Yang, N. Zafar, and N. L. Ward. 2006. Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentus. J. Bacteriol. 188: 6841-6850. 32. Chen, B., M. Doucleff, D. E. Wemmer, S. De Carlo, H. H. Huang, E. Nogales, T. R. Hoover, E. Kondrashkina, L. Guo, and B. T. Nixon. 2007. ATP ground- and transition-states of bacterial enhancer binding AAA+ ATPases support complex formation with their target protein, s54. Stucture 15: 429-440. 33. Smith, T. G., J.-M. Lim, M. V. Weinberg, L. Wells, and T. R. Hoover. 2007. Direct analysis of the extracellular proteome of two strains of Helicobacter pylori. Proteomics 7: 2240-2245. 34. Burtnick, M. N., J. S. Downey, P. J. Brett, J. A. Boylan, J. G. Frye, T. R. Hoover, and F. C. Gherardini. 2007. Insights into the complex regulation of rpoS in Borrelia burgdorferi. Mol. Microbiol. 65: 277-293. 35. Brahmachary, P., G. Wang, S. L. Benoit, M. V. Weinberg, R. J. Maier, and T. R. Hoover. 2008. The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize mice. BMC Microbiol. 8:14. 36. Bagwell, C., S. Bhat, G. M. Hawkins, B. W. Smith, T. Biswas, T. R. Hoover, E. Saunders, C. S. Han, O. Tsodikov, and L. J. Shimkets. 2008. Survival in nuclear waste, extreme resistance, and potential applications gleaned from the genome sequence of Kineococcus radiotolerans SRS30216. PLoS ONE 3(12):e3878. 37. Smith, T. G., L. Pereira and T. R. Hoover. 2009. Helicobacter pylori FlhB processing-deficient variants affect flagellar assembly but not flagellar gene expression. Microbiology 155: 1170-1180. 38. McBride, M. J., G. Xie, E. C. Martens, A. Lapidus, B. Henrissat, R. G. Rhodes, E. Goltsman, W. Wang, J. Xu, D. W. Hunnicutt, A. M. Staroscik, T. R. Hoover, Y.-Q. Cheng, and J. L. Stein. 2009. Novel features of the polysaccharide-digesting gliding bacterium Flavobacterium johnsoniae revealed by genome sequence analysis. Appl. Environ. Microbiol. 75: 6864-6875. 39. Pereira, L., J. Tsang, J. Mrzek, and T. R. Hoover. 2011. The zinc-ribbon domain of Helicobacter pylori HP0958: requirement for RpoN accumulation and possible roles of homologs in other bacteria. Microbial Informatics Exp. 1: 8. 40. Tsang, J., T. G. Smith, L. E. Pereira, and T. R. Hoover. 2013. Insertion mutations in Helicobacter pylori flhA reveal strain differences in RpoN-dependent gene expression. Microbiology 159: 58-67. *41. Miller, K. A., R. S. Phillips, J. Mrzek, and T. R. Hoover. 2013. Salmonella utilizes D-glucosaminate via a mannose family phosphotransferase system permease and associated enzymes. J. Bacteriol. 195: 4057-4066. 42. Boehm, M., I. Haenel, B. Hoy, L. Brondsted, T. G. Smith, T. Hoover, S. Wessler, and N. Tegtmeyer. 2013. Extracellular secretion of protease HtrA from Campylobacter jejuni is highly efficient and independent of its protease activity and flagellum. Eur. J. Microbiol. Immunol. 3: 163-173. 43. Samuels, D. J., J. G. Frye, S. Porwollik, M. McClelland, J. Mrzek, T. R. Hoover, and A. C. Karls. 2013. Use of a promiscuous, constitutively-active bacterial enhancer-binding protein to define the s54 (RpoN) regulon of Salmonella Typhimurium LT2. BMC Genomics 14: 602. 44. Tsang, J. and T. R. Hoover. 2014. Requirement of the flagellar protein export apparatus component FliO for optimal expression of flagellar genes in Helicobacter pylori. J. Bacteriol. 196: 2709-2717. 45. Tsang, J., T. Hirano, T. R. Hoover, and J. L. McMurry. 2015. Helicobacter pylori FlhA binds the sensor kinase and flagellar gene regulatory protein FlgS with high affinity. J. Bacteriol. 197: 1886-1892. This paper was selected as an Article of Significant Interest by the Editors. 46. Tsang, J. and T. R. Hoover. 2015. Basal body structures differentially affect transcription of RpoN- and FliA-dependent flagellar genes in Helicobacter pylori. J. Bacteriol. 197: 1921-1930. 47. Miller, K. A., R. S. Phillips, P. B. Kilgore, G. L. Smith, and T. R. Hoover. 2015. A mannose family phosphotransferase system permease and associated enzymes are required for utilization of fructoselysine and glucoselysine in Salmonella enterica serovar Typhimurium. J. Bacteriol. 197: 2831-2839. This paper was featured in Atlas of Science (Salmonella savors flavors, December 15, 2015, http://atlasofscience.org/salmonella-savors-flavors/). 48. Martinez, L. E., J. M. Hardcastle, J. Wang, Z. Pincus, J. Tsang, T. R. Hoover, R. Bansil, and N. R. Salama. 2016. Helicobacter pylori strains vary cell shape and flagellum number to maintain robust motility in viscous environments. Mol. Microbiol. 99: 88-110. 49. Phillips, R. S., P. Poteh, K. A. Miller, and T. R. Hoover. 2017. STM2360 encodes a novel D-lysine/D-ornithine decarboxylase in Salmonella enterica serovar Typhimurium. Arch. Biochem. Biophys. 634: 83-87. 50. Phillips, R. S., S. C. Ting, A. B Tetsadijo, K. L. Anderson, K. M. Friez, K. A. Miller, and T. R. Hoover. 2017. Properties and mechanism of D-Glucosaminate-6-phosphate ammonia-lyase: an aminotransferase family enzyme with D-amino acid specificity. Biochim. Biophys. Acta - Proteins Proteomics doi: 10.1016/j.bbapap.2017.12.006. II. Book chapters 1. Shah, V. K., T. R. Hoover, J. Imperial, T. D. Paustian, G. P. Roberts, and P. W. Ludden. 1988. Role of nif gene products and homocitrate in the biosynthesis of iron-molybdenum cofactor. In Proceedings of the VIIth International Congress on Nitrogen Fixation, H. Boethe and W. E. Newton, eds. (Fischer-Verlag, Stuttgart), pp. 115-120. 2. Santero, E., T. Hoover, and S. Kustu. 1990. Mechanism of transcription from nif promoters: involvement of IHF. In Nitrogen Fixation: Achievements and Objectives, P. M. Gresshoff, L. E. Roth, G. Stacey, and W. E. Newton, eds. (Chapman and Hall, New York), pp. 459-466. 3. Weiss, D. S., K. E. Klose, T. R. Hoover, A. K. North, S. C. Porter, A. B. Wedel, and S. Kustu. 1992. Prokaryotic enhancers. In Transcriptional Regulation, S. L. McKnight and K. R. Yamamoto, eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.), pp. 667-694. 4. Hoover, T. R. 2000. Control of nitrogen fixation genes in Klebsiella pneumoniae. In Prokayotic Nitrogen Fixation: A Model System for the Analysis of a Biological Process, E. Triplett, ed., (Horizon Scientific Press, Wymondham, UK). 5. Hoover, T. R. 2001. Bacterial transcription factors. In Encyclopedia of Genetics, S. Brenner and J. Miller, editors-in-chief (Academic Press, London, UK), pp. 163-165. 6. Smith, T. G. and T. R. Hoover. 2009. Deciphering bacterial flagellar gene regulatory networks in the genomic era. In Advances in Applied Microbiology, A. I. Laskin, S. Sariaslani and G. M. Gadd, eds. (Academic Press, San Diego), vol. 67, pp. 257-295. 7. Miller, K. A. and T. R. Hoover. 2015. Role of Salmonella metabolic genes in colonization of food animals. In Salmonella: Prevalence, Risk Factors and Treatment Options. C. B. Hackett, ed. (Nova Science Publishers, Hauppauge, NY), pp. 137-158. ISBN:978-1-63463-651-3. III. Invited Reviews 1. Hoover, T. R., J. Imperial, P. W. Ludden, and V. K. Shah. 1988. Biosynthesis of the iron-molybdenum cofactor of nitrogenase. BioFactors 1: 199-205. 2. Hoover, T. R. and P. W. Ludden. 1988. Biosynthesis and maturation of the nitrogenase enzyme complex. Comments Agric. and Food Chemistry 1: 265-287. 3. Kelly, M. T. and T. R. Hoover. 1999. Bacterial enhancers function at a distance. ASM News 65: 484-489. 4. Xu, H. and T. R. Hoover. 2001. Transcriptional activation at a distance in bacteria. Curr. Opin. Microbiol. 4: 138-144. 5. Beck, L. L., T. G. Smith, and T. R. Hoover. 2007. Look, no hands! Unconventional transcriptional activators in bacteria. Trends Microbiol. 15: 530-537. 6. Anderson, J. K., T. G. Smith, and T. R. Hoover. 2010. Sense and sensibility: flagellum-mediated gene regulation. Trends Microbiol. 18: 30-37. 7. Buck, M. and T. R. Hoover. 2010. An ATPase R-finger leaves its print on transcriptional activation. Structure 18: 1391-1392. 8. Tsang, J. and T. R. Hoover. 2014. Themes and variations: Regulation of RpoN-dependent flagellar genes across diverse bacterial species. Scientifica 2014, doi: 10.1155/2014/681754. Denotes co-author who was a graduate student in my lab. Denotes co-author who was an undergraduate student in my lab. *Denote publications in which the contributions of undergraduates in my lab were acknowledged. Grants Complete: "Transcriptional Activation at the Dicarboxylic Acid Transport (dctA) Gene of Rhizobium", University of Georgia Research Foundation Junior Faculty Research Grant; $7,000; January 1, 1992 - December 31, 1992 "Transcriptional Activation at the Dicarboxylate Transport Gene of Rhizobium", United States Department of Agriculture, $250,000; September 15, 1992 - August 31, 1996; (Competitive renewal began 9/15/94); principal investigator Cell Envelope Proteins of Planctomycetes, University of Georgia Research Foundation Junior Faculty Research Grant; $7,000; January 2, 1997 - December 31, 1997 "Transcriptional Activation by Rhizobium meliloti DCTD", National Science Foundation, $682,076; September 15, 1995 - August 31, 1999; principal investigator "Prokayotic Diversity - An Organismal Approach" (Research Training Grant), National Science Foundation, $2,030,782; October 1, 1994 - September 30, 1999; one of twenty-five participants Metal Regulation in Host Colonization by B. burgdorferi, National Institutes of Health, $611,051; March 1, 1999 February 28, 2002; role: PI (grant originally awarded to Frank Gherardini) Transcriptional Activation with Sigma54-Holoenzyme, National Science Foundation, $320,000; September 1, 1999 - August 31, 2002; role: PI Acetone Metabolism in Helicobacter pylori, National Institutes of Health, $147,200; June 1, 2003 May 31, 2005; role: PI REU Site: Research in Prokaryotic Biology, National Science Foundation, $209,892; May 1, 2002 April 30, 2005; role: co-PI (Ellen Neidle, PI) REU Site: Research in Prokaryotic Biology, National Science Foundation, $225,045; 04/01/05-03/31/08; role: PI (Wendy Dustman, co-PI) Microbial Genome Sequencing: Genome Sequence of the Budding Bacterium Hyphomonas neptunium, National Science Foundation, $325,000; September 1, 2002 August 31, 2004 (no cost extension until 8/31/05); role: PI (Yves Brun and Naomi Ward, co-PIs) Transcriptional Control of the Helicobacter pylori RpoN Regulon, National Institutes of Health (AI080923), $145,000; December 15, 2008 December 14, 2010 (no-cost extension until 12/14/2011); role: PI REU Site: Research in Prokaryotic Biology, National Science Foundation (DBI-1062589), $300,000; May 27, 2011 May 26, 2014; role: PI Genome-wide analysis of the Salmonella RpoN Regulon, National Science Foundation (MCB-1051175), $682,664; February 1, 2011 January 31, 2014 (no cost extension until 1/31/2016); role: PI Collaborative RUI: Regulation of flagellar biogenesis in Helicobacter pylori, National Science Foundation (MCB-1244242), $238,615; August 1, 2013 July 31, 2016 (no cost extension until 7/31/2017); role: PI Former and Current Graduate Students Former graduate students Shovon Ashraf; M.S. 1995; Thesis title: "Analysis of s54-Dependent Promoters using P22 Challenge Phage"; Present position: Technical Specialist, Sterne, Kessler, Goldstein & Fox, P.L.L.C., Washington, D.C. Joon H. Lee; Ph.D. 1996; Thesis title: "In Vitro Study of DCTD, a s54-Dependent Transcriptional Activator"; Present position: Research Scientist, Department of Ophthalmology, Yonsei University, Korea Ying-Kai Wang; Ph.D. 1997; Thesis title:  Genetic and Biochemical Characterization of Rhizobium meliloti DctD, a s54-Dependent Activator ; Present position: Research Scientist, Bristol-Meyer-Squibb, New Haven, Connecticut Yan Gao; M.S. 1998; Thesis title:  Mutational Analysis of the Phosphate-Binding Loop of Rhizobium meliloti DctD, a s54-Dependent Activator ; Present position: Research Scientist, Syngenta, Research Triangle Park, North Carolina Beth Leary; M.S. 1998; Thesis title:  Preliminary Molecular and Ultrastructural Analyses of Planctomyces limnophilus; Present position: unknown Mary T. Kelly, Ph.D. 1999; Thesis title: Mutational analysis of a sigma factor that functions with bacterial enhancer-binding proteins; Present position: Deputy Vice-Chancellor (Research, Development and Industry), Charles Sturt University, Canberra, Australia Mona Dashti, Ph.D. 2001; Thesis title: An unusual s54-dependent activator from Helicobacter pylori and its role in flagellar biogenesis ; Present position: Assistant Professor, Department of Microbiology, Kuwait University, Kuwait Andrea Polacchini de Oliveira, M.S. 2003; Thesis title:  Characterization of SisK and SisR, an NtrB/C-type regulatory system in the Lyme disease spirochete ; Present position: Research Technician, University of Pennsylvania Hao Xu, Ph.D. 2003; Thesis title:  Characterization of the AAA+ domain of the Sinorhizobium meliloti s54-dependent activator DctD; Present position: Research Scientist, Synageva BioPharma, San Diego, California Priyanka Brahmachary, Ph.D. 2004; Thesis title: Novel aspects of flagellar biogenesis and virulence in Helicobacter pylori; Present position: at home with children Jennifer Treglown, Ph.D. 2004; Thesis title: Responses to environmental stress triggers differential expression and cellular damage in Borrelia burgdorferi; Present position: Validation Associate III, Baxter Bioscience James Warren, III, Ph.D. 2004; Thesis title: A molecular genetic approach to stabilizing bioactive peptides via protein-based motifs; Present position: unknown Lara Pereira, Ph.D. 2005; Thesis title: Control of the RpoN flagellar regulon in Helicobacter pylori; Present position: Senior Service Fellow, Centers for Disease Control, Atlanta, GA Todd G. Smith, Ph.D. 2009; Thesis title: Regulation of the Helicobacter pylori RpoN regulon by the flagellar protein export apparatus; Present position: Microbiologist, Solution One Industries (Centers for Disease Control, Atlanta, GA) Jennifer Tsang, Ph.D. 2014; Thesis title: Influence of the flagellar basal body on transcription of the RpoN regulon in Helicobacter pylori; Present position: Scientific Content Editor, Journal of Visualized Experiments, Cambridge, MA Katherine Miller, Ph.D. 2015; Thesis title: Identifying functions of RpoN-dependent genes in Salmonella, Present position: Business Development Manager, Food Safety Net Services, Columbus, OH Current graduate students Bowen Meng, Ph.D. candidate Joshua Chu, Ph.D. candidate Katherine Haney, Ph.D. student Invited Talks and Presentations University of Georgia, Division of Biological Sciences, Athens, GA, March 1992 Southeastern Branch of American Society for Microbiology, Clearwater Beach, FL, November 1993 Gordon Conference on Nitrogen Fixation, New London, NH, June 1996 FASEB Conference on Transcription Initiation in Prokaryotes, Saxtons River, VT, July 1997 98th General Meeting of American Society for Microbiology, session on Transcription Regulation by Response Regulators, Atlanta, GA, May 1998 University of Georgia, Department of Biochemistry and Molecular Biology, May 1998 National Institutes of Health, Rocky Mountain Labs, Hamilton, MT, August 1999 University of California-Irvine, Department of Microbiology and Molecular Genetics, Irvine, CA, March 2002 University of California-Los Angeles, Department of Chemistry and Biochemistry, Los Angeles, CA, March 2002 Georgia State University BIOTECH Symposium, Atlanta, GA, September 2006 University of Florida, Department of Cell Biology and Microbiology, Gainesville, FL, October 2006 Southeastern Branch Meeting of the American Society for Microbiology, Auburn, AL, November 2007 Georgia State University, Department of Biology, Atlanta, GA, January 2013 Uniformed Services University, Department of Microbiology, Bethesda, MD, February 2013 University of Liverpool, Institute of Integrative Biology, Liverpool, UK, May 2013 Imperial College, Division of Cell & Molecular Biology, London, UK, May 2013 University of Iowa Carver School of Medicine, Department of Microbiology, Iowa City, IA, December 2016 University of Georgia, Department of Microbiology, Athens, GA, October 2017 Resident Instruction Courses of Instruction Experimental Microbiology Laboratory (MIBO 4600L/6600L). Laboratory techniques used for the basic study of bacterial metabolism and physiology, including methods for monitoring cell growth, enzyme induction, protein purification, and isolation of specific groups of bacteria. Revised the course and taught 100% of course: 1998 2001; Taught 50% of course: 2002-present. Principles of Biology II (BIOL 1108). Introductory biology course for students majoring in biological sciences and related fields. Course focuses on microbial diversity and physiology; plant and animal diversity, growth, reproduction and physiology; and ecology. Taught 25% of course: 2011. Microbes from the Old Testament to the New York Times (FRES 1010). Freshman survey of microorganisms and their impact on society. Taught 100% of course: 2001, 2002 and 2003. Reading Biomedical Research Literature for Dummies (FYOS 1001). Seminar course for first-year students to introduce students to various types of biomedical research literature; strategies for reading scientific papers and graphed data; and how to a curriculum vitae and prepare personal statement. Taught 100% of the course: 2011. Microbe Fiction (FYOS 1001). Seminar course for first-year students that uses popular novels to introduce topics relevant to microbiology, including biomedical ethics, responsible conduct of research, pathogenesis, epidemiology and bioterrorism. Taught 100% of the course: 2012, 2014. Microbe Hunters (FYOS 1001). Seminar course for first-year students that examines biographies of microbiologists using the book Microbe Hunters by Paul de Kruif. Taught 100% of the course: 2015, 2016. My Microbiome and Me (FYOS 1001). Seminar course for first-year students that explores recent microbiome research findings using the book I Contain Multitudes: The Microbes Within Us and a Grander View of Life by Ed Yong. Taught 100% of the course: 2017. Microbial Genetics (MIBO 4450/6650). Basic principles gene regulation in bacteria with emphasis on mechanisms of transcriptional, post-transcriptional, translational and post-translation control. Computer lab component focuses on methods used for genomic analysis. Taught 17% of course: 2005 2010; helped revise the course. Fundamentals of Microbiology (MIB 409/609). Basic principles and techniques of general microbiology, with emphasis on growth, nutrition, inheritance, ultrastructure, and physiology of representative types of microorganisms. Taught 50% of course: 1992 - 1998, twice per year Microbiology and Health Care (MIB 250). Microbiology course designed for nursing students. Taught 100% of course: 1992, 1995 Advanced Microbial Physiology (MIB 861). Graduate level course on bacterial metabolism, including fermentative processes, respiration, photosynthesis, methanogenesis, and nitrogen and sulfur metabolism. Taught 30% of course: 1992 - 1998 Seminar in Microbiology (MIB 816; MIBO 8160). Techniques involved in effective seminar presentation, including preparation of visual aids, logical development of topic, and delivery. Each student presents a practice session to the class, as well as a formal seminar to the department. Taught 50% of course: 1993 1995; 2014 (taught 100% of course) Seminar in Prokaryotic Diversity (MIB 817). Examination of selected topics in microbial metabolism and genetics through review of literature, student presentations, and invited speakers. Taught 50% of course: 1996, 1997; Helped to develop the course. Public and University Service Public Service Judge for Georgia Science and Engineering Fair, 1993-2004 Mentor for Howard Hughes Summer Undergraduate Research Program, 1994 Mentor for Chancellors Initiative Summer Research Program for Minority Undergraduate Students, 1997 Mentor for Peach State Louis Stokes Alliance for Minority Participation, 2007 Advisory Committee for Georgia Performance Standards in Microbiology (recommended curriculum standards for high school microbiology courses), 2008 Editorial Board for Journal of Bacteriology, 2000 - 2010 Ad hoc reviewer for research proposals from: National Science Foundation Science Foundation Ireland United States Department of Agriculture Utah State University Office of Research The Marsden Fund of the Royal Society of New Zealand The Israel Science Foundation #%8 . 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$L^La$gdHgdH $L^La$gd)s ?HJKx~ˉq||obbbbUhy{hL6>OJQJ^Jhy{heOJQJ^Jhy{h6QOJQJ^Jhy{h<AOJQJ^JhHOJQJ^Jh<AOJQJ^JhnNOJQJ^JhKOJQJ^JhSyOJQJ^JhxOOJQJ^Jhy{h/OJQJ^Jhy{hLOJQJ^JhHOJQJ^Jhy{hHOJQJ^JhLOJQJ^J!͎ώގǏԐݐ-JLtxh[NAhy{h5sOJQJ^Jhy{h,(OJQJ^Jhy{hUpOJQJ^Jhy{he6OJQJ]^Jhy{h9SOJQJ^Jhy{hL>OJQJ^Jhy{hXOJQJ^Jhy{h OJQJ^Jhy{hJOJQJ^J$hy{he56OJQJ\]^Jhy{he5OJQJ\^JhHhHOJQJ^Jh OJQJ^Jhy{heOJQJ^Jh-Jt֑Hj)?V}$E^E`a$gd<A $E^Ea$gdCH$E^E`a$gdCH$E^E`a$gd9S $`a$gd9Stv֑ؑ6GHJXi&@AV׽栓sscVch06OJQJ]^Jhy{h'r}6OJQJ]^Jhy{he6OJQJ]^Jhy{h 6OJQJ]^Jh<A6OJQJ]^Jhy{hX6OJQJ]^Jhy{h'r}OJQJ^Jhy{hynJOJQJ^Jhy{h^ [OJQJ^Jhy{h-OJQJ^JUhy{heOJQJ^Jhy{hXOJQJ^JBiotechnology and Biological Sciences Research Council (United Kingdom) Wellcome Trust (United Kingdom) United States Civilian Research and Development Foundation Fondazione Cariplo (Italy) Swiss National Science Foundation National Sciences and Engineering Research Council of Canada Ad hoc reviewer for: ACS Chemical Biology Applied and Environmental Microbiology Archives of Biochemistry and Biophysics Archives of Microbiology Biochemistry and Cell Biology BMC Genomics BMC Microbiology Current Microbiology EMBO Journal EMBO Reports Eukaryotic Cell FEBS Letters FEMS Microbiology Letters FEMS Microbiology Reviews Frontiers in Anti-Infective Drug Discovery (book chapter) Gene Helicobacter Infection and Immunity Journal of Bacteriology Journal of Basic Microbiology Journal of Industrial Microbiology and Biotechnology Journal of Medical Microbiology Journal of Molecular Biology Journal of Proteome Research Microbiology Microbiology and Molecular Biology Reviews Molecular Microbiology Molecular Plant-Microbe Interactions Nucleic Acids Research PLoS Genetics PLoS ONE Proceedings of the National Academy of Science, USA Protein Science Pseudomonas (book chapter review) Research in Microbiology Structure The Desk Encyclopedia of Microbiology (book proposal review) The Open Biomedical Engineering Journal The FEBS Journal Trends in Microbiology Guest Editor, Proceedings of the National Academy of Science, USA, 2015 Review panel for Nitrogen Fixation/Nitrogen Metabolism Program of USDA, 1995 Ad hoc member of review panel for Microbial Physiology Program of NIH, February, 1997 Review panel for NSF/USDA Microbial Genomes, 2003; 2006; 2007 Review panel for Science Foundation Ireland, March, 2005; February, 2006 Organizing Committee for the 1997 Steenbock Symposium, University of Wisconsin-Madison, Madison, Wisconsin, June 11-14, 1997 Review panel for World Class University International, Korean Science and Engineering Foundation, November 2008; November, 2010 Review panel for National Science Foundation, April, 2013; March 2015 External Advisory Board for the University of Florida STEP Program: A STEP Up for the Life Sciences, August 2012-present Advisory Board for the Department of Microbiology and Cell Biology, University of Florida, January 2018-present Service to the University Undergraduate academic advisor - Microbiology majors, 1993 - present Search Committee, Department of Microbiology, 1993, 2000 Safety Representative, Department of Microbiology, 1993 - 1998 Departmental Representative to the Faculty Senate of Franklin College of Arts and Sciences, 1994 - 1997 Professional Concerns Committee of the Faculty Senate, 1994 - 1996 Committee on Committees of Faculty Senate, June 1996 - May, 1997 Steering Committee of the Faculty Senate, 1996-1997 Graduate Affairs Committee, Department of Microbiology, 1994 - 1998 Undergraduate Affairs Committee, Department of Microbiology, 1996 - 2012 Undergraduate Coordinator, Department of Microbiology, 1998 - 2012 Co-organizer, seminar series in Department of Microbiology, 1994 - 1998 Seminar Committee for Research Training Grant ("Prokayotic Diversity - An Organismal Approach"), 1995 1999 Instructor for Summer Workshop in Microbial Physiology for Research Training Grant in Prokaryotic Diversity An Organismal Approach, 1999 Mentor, Honors Program, 2000 - 2009 Associate Department Head, Department of Microbiology, 2001 - 2012 Co-Director, Summer Research Experience for Undergraduates in Prokaryotic Biology, Department of Microbiology, University of Georgia, 2001 2004 Director, Summer Research Experience for Undergraduates in Prokaryotic Biology, Department of Microbiology, University of Georgia, 2004 - 2007 Member, Biomedical and Health Sciences Institute, University of Georgia, 2002 - present Curriculum Committee for Molecular Medicine, Biomedical and Health Sciences Institute, University of Georgia, 2002 2004 Office of Vice-President for Research special committee to investigate a potential ethics violation, 2007 Search Committee, Lecturer in Biology at UGA Griffin campus, 2007 Awards Committee, Department of Microbiology, 2007-2012 Life Sciences Area Committee for Appointment and Reappointment to the Graduate Faculty, University of Georgia, 2007-2010 Outstanding Undergraduate Academic Advisor Award Selection Committee, University of Georgia, 2008 Center for Undergraduate Research Opportunities (CURO) Excellence in Undergraduate Research Mentoring Award Selection Committee, University of Georgia, 2008 and 2009 Five-year Review Committee for the University of Georgia Cancer Center, 2008 Member of Pre-medicine Curriculum Committee, 2010 - 2011 CURO Faculty Torchbearer, University of Georgia, 2010 - 2011 CURO Council, University of Georgia, 2010 2011 Reviewer, CURO Best Paper Award, University of Georgia, 2011 University Review Committee, Life Sciences (Promotion and Tenure Committee), University of Georgia, 2011 Reviewer, CURO Summer Research Fellowships, University of Georgia, 2012 Department Head, Department of Microbiology, University of Georgia, 2012 present Chair, Review Committee for University of Georgia Center for Metalloenzymes, 2014 Member of University of Georgia Biology Curriculum Committee, 2014 present Chair, Review Committee for UGA Department of Plant Biology, 2014 Member, Franklin College of Arts and Sciences Task Force on Experiential Learning, 2015 Chair, Marine Sciences Head Search Committee, University of Georgia, 2015 Member, UGA Institutional Biosafety Committee, 2017 - present     PAGE 12 curriculum vitae for Timothy R. 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