ࡱ> VTW#` (bjbj *H TH$!x6v$#  $n#h%x   (F  :e,l $x] !~!RN&N&N&79<777  777!P P  THE JOURNAL OF PEDIATRICS Childrens Hospital Medical Center, MLC-3021 3333 Burnet Ave. Cincinnati, OH 45229-3039 513-636-7140 FAX: 513-636-7141 PRESS RELEASE For Immediate Release For more information, contact: Brigid Huey, 513-636-7140,  HYPERLINK "mailto:journal.pediatrics@chmcc.org" journal.pediatrics@cchmc.org Pediatricians Call for a Cohesive Definition of Metabolic Syndrome in Children Cincinnati, OH, January 10, 2008 Metabolic syndrome in children represents a potentially serious threat to health in adulthood, yet many parents and caregivers do not have a clear idea of what metabolic syndrome is and why it is dangerous. Metabolic syndrome is a group of cardiovascular risk factors, including obesity, hypertension, prediabetes, and reduced HDL (good) cholesterol. Because it is difficult to know when a child is at risk for metabolic syndrome, some doctors fear that children may not be properly diagnosed as a result. The February 2008 issue of The Journal of Pediatrics focuses on this issue by publishing a series of articles in an attempt to work toward a cohesive definition of metabolic syndrome in children. Five articles of the series were completed by researchers from the Pediatric Metabolic Syndrome Working Group (PMSWG), a team of researchers from various institutions across the United States. The members of the PMSWG explored the potential for a unified and cohesive definition for metabolic syndrome. The researchers evaluated how current definitions relate to the number of children diagnosed with metabolic syndrome. They found that because of the variety of definitions used by pediatricians, it is difficult to estimate the prevalence of the syndrome among children and adolescents. Additionally, the researchers looked at how well each metabolic risk factor predicts future health issues. According to Dr. Terry Huang, these papers represent summaries of the current state of knowledge for factors related to metabolic syndrome. By gathering this information, the PMSWG hopes to provide a frame of reference for pediatricians working with metabolic syndrome. Dr. John Morrison and colleagues from Cincinnati Childrens Medical Center, Cincinnati Jewish Hospital, and Maryland Medical Research Institute collected data from a 25-30 year study concerning cardiovascular risk factors. They found that metabolic syndrome in children may have a direct link to type 2 diabetes in adulthood. In a related article, Dr. Claudio Maffeis and colleagues from The Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology used body mass index (BMI), waist circumference, and weight to height ratios to determine obesity in a group of 974 children. They found that evaluating waist circumference and weight to height ratio measurements may be more accurate in determining metabolic risk than using body mass index alone. These articles demonstrate that symptoms of adult metabolic syndrome begin in childhood and may be directly related to obesity. They also illustrate the need for a clear definition of metabolic syndrome in children. According to Dr. Reginald Washington, once this definition exists, medical providers who care for children will know what to look for in order to identify children who are at risk to develop adult metabolic syndrome. Such a definition could lead to better treatment of childhood metabolic syndrome, which could positively impact the growing obesity epidemic. These studies are reported in the following:  HYPERLINK "http://www.jpeds.com/webfiles/images/journals/ympd/2941.pdf" Finding Thresholds of Risk for Components of the Pediatric Metabolic Syndrome, by Terry T-K Huang, PhD, MPH HYPERLINK "http://www.jpeds.com/article/PIIS0022347607005628/abstract"Metabolic Syndrome Rates in United States Adolescents, from the National Health and Nutrition Examination Survey, 1999-2002 by Stephen Cook, MD, Peggy Auinger, MS, Chaoyang Li, MD, PhD, and Earl S. Ford, MD, MPH HYPERLINK "http://www.jpeds.com/article/PIIS0022347607007731/abstract"Examining Metabolic Syndrome Definitions in Overweight Hispanic Youth: A Focus on Insulin Resistance by Gabriel Q. Shaibi, PhD, PT, and Michael I. Goran, PhD HYPERLINK "http://www.jpeds.com/article/PIIS0022347607007494/abstract"Comparison of Different Definitions of Pediatric Metabolic Syndrome: Relation to Abdominal Adiposity, Insulin Resistance, Adiponectin, and Inflammatory Biomarkers by SoJung Lee, PhD, Fida Bacha, MD, Neslihan Gungor, MD, and Silva Arslanian, MD HYPERLINK "http://www.jpeds.com/article/PIIS0022347607007548/abstract"Defining the Metabolic Syndrome in Children and Adolescents: Will the Real Definition Please Stand Up? by Earl S. Ford, MD, MPH, and Chaoyang Li, MD, PhD HYPERLINK "http://www.jpeds.com/article/PIIS0022347607007706/abstract"Sensitivity, Specificity, and Predictive Values of Pediatric Metabolic Syndrome Components in Relation to Adult Metabolic Syndrome: The Princeton LRC Follow-up Study by Terry T-K Huang, PhD, MPH, Tonya R. Nansel, PhD, Allen R. Belsheim, MA, and John A. Morrison, PhD HYPERLINK "http://www.jpeds.com/article/PIIS0022347607007524/abstract"Childhood Obesity Predicts Adult Metabolic Syndrome: The Fels Longitudinal Study by Shumei S. Sun, PhD, Ruohong Liang, MS, Terry T-K Huang, PhD, MPH, Stephen R. Daniels, MD, PhD, Silva Arslanian, MD, Kiang Liu, PhD, Gilman D. Grave, MD, and Roger M. Siervogel, PhD HYPERLINK "http://www.jpeds.com/article/PIIS0022347607008566/abstract"Metabolic Syndrome in Childhood Predicts Adult Metabolic Syndrome and Type 2 Diabetes Mellitus 25 to 30 Years Later by John A. Morrison, PhD, Lisa Aronson Friedman, ScM, Ping Wang, PhD, and Charles J. Glueck, MD HYPERLINK "http://www.jpeds.com/article/PIIS0022347607008773/abstract"Waist-to-Height Ratio, a Useful Index to Identify High Metabolic Risk in Overweight Children by Claudio Maffeis, MD, Claudia Banzato, MD, and Giorgio Talamini, MD, on behalf of The Obesity Study Group of The Italian Society of Pediatric Endocrinology and Diabetology. The articles appear in The Journal of Pediatrics, Volume 152 Number 2 (February 2008), published by Elsevier. To obtain full text of the articles or author contact information contact Brigid Huey, 513-636-7140,  HYPERLINK "mailto:journal.pediatrics@chmcc.org" journal.pediatrics@cchmc.org. The Journal of Pediatrics is a primary reference for the science and practice of pediatrics and its subspecialties. This authoritative resource of original, peer-reviewed articles oriented toward clinical practice helps physicians stay abreast of the latest and ever-changing developments in pediatric medicine. The Journal of Pediatrics ranks 4th of 74 pediatric journals receiving the most citations (Science Citation Index). URL:  HYPERLINK "http://www.jpeds.com" www.jpeds.com About Elsevier Elsevier is a world-leading publisher of scientific, technical and medical information products and services. Working in partnership with the global science and health communities, Elseviers 7,000 employees in over 70 offices worldwide publish more than 2,000 journals and 1,900 new books per year, in addition to offering a suite of innovative electronic products, such as ScienceDirect ( HYPERLINK "http://www.sciencedirect.com/" http://www.sciencedirect.com/), MD Consult ( HYPERLINK "http://www.mdconsult.com/" http://www.mdconsult.com/), Scopus ( HYPERLINK "http://www.info.scopus.com/" http://www.info.scopus.com/), bibliographic databases, and online reference works. Elsevier ( HYPERLINK "http://www.reedelsevier.com/" http://www.elsevier.com/) is a global business headquartered in Amsterdam, The Netherlands and has offices worldwide. Elsevier is part of Reed Elsevier Group plc ( HYPERLINK "http://www.reedelsevier.com/" http://www.reedelsevier.com/), a world-leading publisher and information provider. Operating in the science and medical, legal, education and business-to-business sectors, Reed Elsevier provides high-quality and flexible information solutions to users, with increasing emphasis on the Internet as a means of delivery. Reed Elsevier's ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange). ### z/ ˼ubOb:) hbh ~CJOJQJ^JaJ)jhbh ~CJOJQJU^JaJ$hbhD >@CJOJQJ^JaJ$hbh ~@CJOJQJ^JaJ$hbhb@CJOJQJ^JaJ'hbh%5@CJOJQJ^JaJhbhx<5@OJQJ^Jhbh ~>*@OJQJ^Jhbh ~B*CJ^Jphhbh ~5@CJ^Jhbh ~5@OJQJ^Jh ~5@CJ4h ~5@CJ4OJQJzP Q R [\ dh`gdbdhgdx<$a$gd ~gd ~   *$gd ~$ & 0P !$`'0*-/2a$gd ~ $*$a$gd ~(/ 0 1 M N Q R  ҿҬuuh[NA4AhNhhbhbOJQJ^Jhbh OJQJ^Jhbhg@OJQJ^Jhbhq9OJQJ^Jhbh ~OJQJ^J'hbh ~5@CJOJQJ^JaJ'hbh5@CJOJQJ^JaJhbh ~@OJQJ^J$hbh ~@CJOJQJ^JaJ$hbh ~0JCJOJQJ^JaJ)jhbh ~CJOJQJU^JaJ/jhbh ~CJOJQJU^JaJ    ) x \ p T^IJZ[\"*v{ٿٱٿ̤٤ٗٗ٤يٿٿٿٿٿ}phbhvOJQJ^Jhbhx<OJQJ^Jhbh8OJQJ^Jhbh%OJQJ^Jhbhg@OJQJ^Jhbh ~6OJQJ^JhbhD >OJQJ^Jhbh OJQJ^Jhbh ~OJQJ^Jhbhq9OJQJ^Jhbh!OJQJ^J,mnYYYYL & FdhEƀlCFgdvMdhEƀlCF`gd% dh`gdx< +,-ij}~WXĵ񨛨vbSFhbhwOJQJ^Jh ch ~0JOJQJ^J'jhFhFOJQJU^JhFOJQJ^Jjh cOJQJU^JhbhvOJQJ^JhbhOJQJ^Jhbh ~OJQJ^Jh0;hx<0JOJQJ^Jh0;h ~0JOJQJ^J'jh0;h0;OJQJU^Jh0;OJQJ^Jjh0;OJQJU^Jkl12񷪷爜yl_lQ='jWhFhFOJQJU^Jjh5OJQJU^JhbhwOJQJ^Jhbh.nnOJQJ^Jhgh ~0JOJQJ^J'jphFhFOJQJU^JjhgOJQJU^JhbhvOJQJ^Jhbh ~OJQJ^Jh[U8h ~0JOJQJ^J'jhFhFOJQJU^JhFOJQJ^Jjh[U8OJQJU^J23'()*pqrȻխqdVBV'j%hFhFOJQJU^Jjh OJQJU^JhbhLOJQJ^Jh7 hL0JOJQJ^Jh7 h.nn0JOJQJ^J'j>hFhFOJQJU^JhFOJQJ^Jjh7 OJQJU^Jhbh%OJQJ^JhbhvOJQJ^Jhbh.nnOJQJ^Jh5h.nn0JOJQJ^Jjh5OJQJU^J(~eeeeL & FdhEƀlCFgdvL & FdhEƀlCFgd%r#&-^~;<ּ֢֔vg֢YEY'jhFhFOJQJU^JjhOJQJU^Jh;h.nn0JOJQJ^J'j hFhFOJQJU^JhFOJQJ^Jjh;OJQJU^JhbhvOJQJ^JhbhOJQJ^Jhbh;E'OJQJ^JhbhLOJQJ^Jhbh.nnOJQJ^Jjh OJQJU^Jh h.nn0JOJQJ^JDE   ( 1 L f g ɼɯɡɔɊ}s}dXG}!jhbhbOJQJU^Jhb@OJQJ^Jhbhb@OJQJ^JhbOJQJ^JhbhbOJQJ^Jhx<OJQJ^Jhbh;E'OJQJ^Jhbh ~5OJQJ^JhbhwOJQJ^JhbhvOJQJ^Jhbh ~OJQJ^Jhbh.nnOJQJ^JjhOJQJU^Jhh.nn0JOJQJ^Jf g ! !##%%(((((}{dgd ~gd ~ $dha$gdx< $%dhgdx< dhgdx<dhgdx<IdhEƀlCFgdv !!! !9!X"q"y"{""""""""#####$ھs_PsE<hbh ~^Jhbh ~0J^Jhbh ~0JOJQJ^J'j hbh ~OJQJU^J!hbh ~B* OJQJ^Jph!jhbh ~OJQJU^Jhbh ~H*OJQJ^Jhbh ~OJQJ^Jhbh ~5OJQJ^JhbhbOJQJ^Jhbhb0JOJQJ^J!jhbhbOJQJU^J'jhbhbOJQJU^J$$$$$$$$$$ %!%:%;%F%G%p%q%r%%%%%%%%%%&&&&&&&&((hbh ~OJQJ^Jhbh ~PJ^JjP hbh ~U^Jhbh ~0J^Jjhbh ~U^Jhbh ~^Jhbhb^J%(/ =!"#`$% DyK yK Hmailto:journal.pediatrics@chmcc.orgDyK yK xhttp://www.jpeds.com/webfiles/images/journals/ympd/2941.pdfDyK yK vhttp://www.jpeds.com/article/PIIS0022347607005628/abstractDyK yK vhttp://www.jpeds.com/article/PIIS0022347607007731/abstractDyK yK vhttp://www.jpeds.com/article/PIIS0022347607007494/abstractDyK yK vhttp://www.jpeds.com/article/PIIS0022347607007548/abstractDyK yK vhttp://www.jpeds.com/article/PIIS0022347607007706/abstractDyK yK vhttp://www.jpeds.com/article/PIIS0022347607007524/abstractDyK yK vhttp://www.jpeds.com/article/PIIS0022347607008566/abstractDyK yK vhttp://www.jpeds.com/article/PIIS0022347607008773/abstractDyK yK Hmailto:journal.pediatrics@chmcc.orgDyK www.jpeds.comyK ,http://www.jpeds.com/DyK http://www.info.scopus.com/yK 8http://www.info.scopus.com/8@8  ~Normal_HmH sH tH DA@D Default Paragraph FontRiR  Table Normal4 l4a (k(No List HOH ~Style0CJOJQJ_HhmH sH tH 8+@8  ~ Endnote TextCJ0U@0 ~ Hyperlink>*B*D^@"D ~ Normal (Web) ddOJQJ*W@1*  ~Strong5\H@BH x< Balloon TextCJOJQJ^JaJ@OQ@ x< Char CharCJOJQJ^JaJFV@aF 5FollowedHyperlink >*B* ph HzPQR[\ m n (~fg  00000000000000000000000 0 0 0 0 0 0 0 0 00000000000000zPQR[\ m n (~fg  00000000000000000000000 0 0 0 0 0 0 0 0 00000000000000/  2r $( "#(!(0M ,}Wk2)q;D :Fq XXXXXXXXXXXXXtXtXXtXt8@0(  B S  ? _Hlt188849944 _Hlt188849945 _Hlt123980255 _Hlt123980256!! @@@@"" &u9'u94j@(u9?)u9@*u9>@+u9dD,u9@-u9C.u9D/u9@0u9>      -5<<hlxxLLGG    =*urn:schemas-microsoft-com:office:smarttags PlaceType=*urn:schemas-microsoft-com:office:smarttags PlaceNameB*urn:schemas-microsoft-com:office:smarttagscountry-region> *urn:schemas-microsoft-com:office:smarttags PostalCode9 *urn:schemas-microsoft-com:office:smarttagsState8*urn:schemas-microsoft-com:office:smarttagsCity9*urn:schemas-microsoft-com:office:smarttagsplace  c  mx X 3 ~Xl)<E  bx*@>~ ~nP=h^`OJQJo(hHhpp^p`OJQJ^Jo(hHoh@ @ ^@ `OJQJo(hHh^`OJQJo(hHh^`OJQJ^Jo(hHoh^`OJQJo(hHh^`OJQJo(hHhPP^P`OJQJ^Jo(hHoh  ^ `OJQJo(hHhhh^h`OJQJo(hHh88^8`OJQJ^Jo(hHoh^`OJQJo(hHh  ^ `OJQJo(hHh  ^ `OJQJ^Jo(hHohxx^x`OJQJo(hHhHH^H`OJQJo(hHh^`OJQJ^Jo(hHoh^`OJQJo(hH~ ~bx*                  '&q9'g7 L;%;E'5V5[U8E<x<D >g@fTU cmj.nn!q]@|tg]՜.+,D՜.+,H hp  CCHMC;  THE JOURNAL OF PEDIATRICS Title  8@ _PID_HLINKSA fMW0http://www.reedelsevier.com/s MW-http://www.reedelsevier.com/s yd*http://www.info.scopus.com/s D'http://www.mdconsult.com/s L$http://www.sciencedirect.com/s Y!http://www.jpeds.com/s x $mailto:journal.pediatrics@chmcc.orgs hv;http://www.jpeds.com/article/PIIS0022347607008773/abstracts ow;http://www.jpeds.com/article/PIIS0022347607008566/abstracts m|;http://www.jpeds.com/article/PIIS0022347607007524/abstracts m~;http://www.jpeds.com/article/PIIS0022347607007706/abstracts az;http://www.jpeds.com/article/PIIS0022347607007548/abstracts lw ;http://www.jpeds.com/article/PIIS0022347607007494/abstracts j} ;http://www.jpeds.com/article/PIIS0022347607007731/abstracts b~;http://www.jpeds.com/article/PIIS0022347607005628/abstracts %a<http://www.jpeds.com/webfiles/images/journals/ympd/2941.pdfs x $mailto:journal.pediatrics@chmcc.orgs   !"#$&'()*+,./0123456789:;<=>?@BCDEFGHJKLMNOPSRoot Entry F5x]UData %1Table-b&WordDocument*HSummaryInformation(ADocumentSummaryInformation8ICompObjq  FMicrosoft Office Word Document MSWordDocWord.Document.89qRoot Entry F@Wu]UData %1Table-b&WordDocument*H  !"#$&'()*+,./0123456789:;<=>?@BCDEFGH`YZ[\]^_՜.+,D՜.+,H hp  CCHMC;  THE JOURNAL OF PEDIATRICS Title  8@ _PID_HLINKSA fMW0http://www.reedelsevier.com/s MW-http://www.reedelsevier.com/s yd*http://www.info.scopus.com/s D'http://www.mdconsult.com/s L$http://www.sciencedirect.com/s Y!http://www.jpeds.com/s x $mailto:journal.pediatrics@chmcc.orgs hv;http://www.jpeds.com/article/PIIS0022347607008773/abstracts ow;http://www.jpeds.com/article/PIIS0022347607008566/abstracts m|;http://www.jpeds.com/article/PIIS0022347607007524/abstracts m~;http://www.jpeds.com/article/PIIS0022347607007706/abstracts az;http://www.jpeds.com/article/PIIS0022347607007548/abstracts lw ;http://www.jpeds.com/article/PIIS0022347607007494/abstracts j} ;http://www.jpeds.com/article/PIIS0022347607007731/abstracts b~;http://www.jpeds.com/article/PIIS0022347607005628/abstracts %a<http://www.jpeds.com/webfiles/images/journals/ympd/2941.pdfs x $mailto:journal.pediatrics@chmcc.orgs SummaryInformation(ADocumentSummaryInformation8XCompObjq