ࡱ>  bjbj Hxx, ########87$+%#Q%&&&&'' 'PQQQQQQ$YUW$Q]#-''--$Q##&&Q`2`2`2-~#&#&P`2-P`2`2NI110). Most relevant to the current application Jennewein M, Lewis MA, Zhao D, Tsyganov T, Slavine N, He J, Watkins L, Kodibagkar VD, OKelly S, Kulkarni P, Antich PP, Hermanne A, Rsch F, Mason RP and Thorpe PE: Vascular imaging of solid tumors in rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserine, Clin. Cancer Res., 2008; 14: 1377-1385. PMID: 18316558 Mason RP, Zhao D, Pacheco-Torres J, Cui W, Kodibagkar VD, Gulaka PK, Hao G, Thorpe P, Hahn EW: Peschke P: Multimodality imaging of hypoxia in preclinical settings, QJ Nucl. Med. Mol. Imaging 54(3):259-80 2010 Liu L and Mason RP: Imaging (-galactosidase activity in human tumor xenografts and transgenic mice using a chemiluminescent substrate, PloS ONE Online August 6, 2010 PMCID: PMC2917367 A Perspective on Vascular Disrupting Agents that Interact with Tubulin: Preclinical Tumor Imaging and Biological Assessment, R. P. Mason, D. Zhao, L. Liu, M. L. Trawick, and K. G. Pinney, Integr. Biol., 3, 375-387, 2011 DOI: 10.1039/C0IB00135J; PMID: 21321746 Dual 19F/1H MR gene reporter molecules for in vivo detection of -galactosidase J.-X. Yu, V. D. Kodibagkar, R. R. Hallac, L. Liu, and R. P. Mason, Bioconjugate Chem., 23, 596"603 (2012), DOI: 10.1021/bc200647q Additional recent publications of importance to the field (in chronological order) Zhou H, Luby-Phelps K. Mickey BE, Habib A, Mason RP, Zhao D, Dynamic near-infrared optical imaging of 2-deoxyglucose uptake by intracranial glioma of athymic mice, PloS ONE, 2009. PMCID: PMC2778127 Xie D, Gore C, Liu J, Pong R-C, Mason R, Hao G, Long M, Kabbani W, Yu L, Zhang H, Chen H, Sun X, Boothman D, Min W, Hsieh J-T: The role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis, PNAS (USA),  HYPERLINK "http://www.pnas.org/cgi/doi/0908133107/pnas.0908133107 online early edition 2010" 2010. PMID: 20080667 Karam JA, Huang S, Fan J, Stanfield J, Schultz RA, Pong RC, Sun X, Mason RP, Xie XJ, Niu G, Chen X, Frenkel EP, Sagalowsky AI, Hsieh JT,  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/20734393" Upregulation of TRAG3 gene in urothelial carcinoma of the bladder. Int. J. Cancer. 2010 Aug 23. [Epub ahead of print] PMID: 20734393 Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketonic hypoglycemic death B. Kucejova, N. Sunny, A. D. Nguyen, R. Hallac, X. Fu, S. Pea-Llopis, R. P. Mason, R. DeBerardinis, X.-J. Xie, R. DeBose-Boyd, V. Kodibagkar, S. Burgess, and J. Brugarolas, Oncogene, 1-14, 2011 PMID: 21217781  HYPERLINK "http://www.nature.com/onc/journal/vaop/ncurrent/pdf/onc2010587a.pdf" http://www.nature.com/onc/journal/vaop/ncurrent/pdf/onc2010587a.pdf In vivo near-infrared spectroscopy and MRI monitoring of tumor response to Combretastatin A4 phosphate correlated with therapeutic outcome D. Zhao, C.-H. Chang J. G. Kim., H. Liu., R. P. Mason, Int. J. Radiat. Oncol. Biol. Phys.,  HYPERLINK "http://www.redjournal.org/issues?issue_key=S0360-3016(11)X0005-6"  80, (2) , 574-581 (2011) epub doi:10.1016/j.ijrobp.2010.12.028; PMID: 21345614  Novel Fe3+-Based 1H MRI -Galactosidase Reporter Molecules, J.-X. Yu, P. K. Gulaka, L. Liu, V. D. Kodibagkar, R. P. Mason, ChemPlusChem., 77 (5), 370-378 (2012) DOI: 10.1002/cplu.201100072 Oxygenation in Cervical Cancer and Normal Uterine Cervix assessed using BOLD MRI at 3 T R. R. Hallac, Y. Ding, Q. Yuan, R. W. McColl, J. Lea, R. D. Sims, P. T. Weatherall, and R. P. Mason, NMRBiomed, accepted 2012 epub DOI:10.1002/nbm.2804 Tubulin-Destabilizing Agent BPR0L075 Induces Vascular-Disruption in Human Breast Cancer Mammary Fat Pad Xenografts L. Liu, H. Beck, X. Wang, H.-P. Hsieh, R. P. Mason, and X. Liu, PlosOne accepted 2012  HYPERLINK "http://pubs.acs.org/doi/abs/10.1021/jm300520q" 6-Trifluoromethyl Pyridoxine: Novel 19F-NMR pH Indicator for In Vivo Detection J.-X. Yu, W. Cui, V. A Bourke, and R. P. Mason, Bioconjugate Chem. (Web): July 9, 2012 DOI: 10.1021/jm300520q Serial non-invasive monitoring of renal disease following immune-mediated injury using near-infrared optical imaging Y. Du, S. An, L. Liu, , L. Li, X. J. Zhou, R. P. Mason , C. Mohan, PlosOne accepted 2012 D. Research Support Current RP120670-P3 Mason (PI) 06/12 04/17 CPRIT P3: Effects of Hypoxia (Main PI Timmerman) Major Goal: To evaluate tumor oxygenation in pre-clinical models and translate measurements to human lung cancer patients. Assess the ability to determine hypoxia, modulate hypoxia and enhance radiation response. RP110441-C1 Mason (PI) 06/11 04/16 CPRIT C1: In Vivo Imaging Core (Main PI Ward) Major Goal: To engineer enhanced antibodies for improved targeting of tumor associated phosphatidylserine- the core is responsible for pharmacokinetics and imaging. P30 CA142543-01 Willson (PI) 08/10 07/15 NIH/NCI Cancer Center Support Grant Major Goal: Provide Infrastructure support Role: Small animal imaging Resource director 1 R01 CA140674-01 (Pinney; Mason UTSW PI) 06/10 03/15 NIH/NCI subcontract w/ Baylor University Discovery and Development of Improved Chemotherapeutic Agents with Enhanced Selectivity for the Tumor Microenvironment Major Goal: Evaluation of novel vasculature disrupting agents R01 CA139043-01A1 Mason (PI) 01/10 12/14 NIH/NCI Hypoxia and Radiotherapy: Evaluation and Mitigation in Tumors Major Goal: Develop a prognostic test to reveal tumor hypoxia Role: Principal Investigator U24CA126608A SAIRP Mason (PI) 04/07-03/13 NIH/National Cancer Institute UT Southwestern Small Animal Imaging Resource Major Goal: Oversight of multi-modality imaging resource Role: Principal Investigator Recently Completed R21 EB009795-01 Yang; Mason (PI) 08/09 07/12 NIH/NIBIB- subcontract w/UT Arlington Enabling Aliphatic Biodegradable Photoluminescent Polymeric Biomaterials Major Goal: Develop in vivo applications of novel polymeric materials. Role: Principal Investigator of subcontract PC074348 Timmerman (PI) 05/08-05/11 US Department of Defense Stereotactic Body Radiation Therapy for Underserved Populations of Men with Low- and Intermediate-Risk Prostate Cancer Major Goal: Assess predictive factors influencing radiotherapy of human prostate tumors Role: Co-Investigator PC081501 Thorpe (PI) 04/09-03/11 US Department of Defense Targeting Phosphatidylserine to Improve Hormone Therapy of Prostate Cancer Major Goal: To develop a new drug (1N11) that will improve the effectiveness of traditional hormone therapy for prostate cancer that has metastasized to the lymph nodes and lungs of mice bearing implanted and spontaneous prostate tumors Role: Co-Investigator 1R21 CA132096-01A1 Kodibagkar (PI) 03/09-02/11 NIH, NCI 1H MRI Based Nanosensors for Imaging Tumor Oxygenation Major Goal: Develop HMDSO based nanoemulsions as proton MRI pO2 reporter nanoprobes and to use them to explore the tumor micro environmental response to combination chemotherapy Role: Co-Investigator 1R21CA120774-01A1 Mason (PI) 04/07-11/10 NIH/National Cancer Institute MAGIC Magnetic Resonance Assessment of Gene Imaging Constructs Major Goal: Design, synthesize, and evaluate novel 1H MRI gene reporters Role: Principal Investigator BC051255 - W81XWH-06-1-0475 Mason (PI) 04/06-06/10 DOD Breast Cancer Initiative: IDEA Development Award (no cost extension) Breast Tumor Detection and Treatment Using Tarvacin Labeled with Arsenic Radionuclides Role: Principal Investigator 1S10RR02564801 Mason (PI) 05/09 - 04/10 ARRA-NIH Small Animal Ultrasound System (VisualSonics Vevo 770) Role: Principle Investigator 081-07 Mason (PI) 08/07-02/10 The Mary Kay Ash Charitable Foundation Predicting Treatment Response for Cervical Cancer: Non-Invasive Assessment Using BOLD MRI Develop two new MRI methods sensitive to tumor oxygen concentrations Role: Principal Investigator PC050766 - W81XWH-06-1-0149 Mason (PI) 09/05-12/09 DOD Prostate Cancer Initiative: IDEA 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