ࡱ>  bjbj &jjl*-----|*b/b/b/b/b/-1-1-1lnnnnnn$ -10@-1-1-12b/b/222-1b/b/l2-1l226b/V/ @*(- 2 022 N-Acetyl-L-Cysteine Hazardous Substances Policy - Assessment CHEMICAL HAZARD AND RISK ASSESSMENT School of Biosciences Name of supervisorDr. C. SweetAssessment Number*1863 SignatureAssessorMr. E.W.A. BrydonDate of Assessment07.09.01 Signature Notes A School COSHH form in Word is available on the School Server. Available from the Health and Safety Unit. Guidance on making an assessment is given in Making a Chemical Hazard and Risk Assessment. Guidance is also available from Guidance on Completing the Chemical Hazard and Risk Assessment Form. Use a continuation sheet to expand any section of this form in hard copy version. 1LOCATION OF THE WORK ACTIVITYS105, S106B 2PERSONS WHO MAY BE AT RISKList names where possibleAll members of Dr. C. Sweets group present and future; currently Mr. E. W. A. Brydon, Dr. S. J. Morris, Miss. I. Y. Pappworth, Miss K. Baluch, Dr. M. Kirby, Miss K.. Ball and Mr . N. Sharif, and future M.Res. or 3rd year project students. 3ACTIVITY ASSESSEDN-Acetyl-L-Cysteine inhibition of virus-induced apoptosis. 4MATERIALS INVOLVEDAttach copies of data sheet(s)NAMEAMOUNT max/storedHAZARDRISK PHRASESHAZDAT NO***BIOSCIENCESNO***N-Acetyl-L-Cysteine10gCautionCaution: Avoid contact and inhalation. 5INTENDED USE**Give brief details and attach protocol/instructionsTo be used as a tissue culture medium supplement, pre- and post virus incubation, on cell monolayers in order to inhibit apoptosis. Weighed amounts will be diluted to concentrations under 1M in tissue culture medium in the class 2 safety cabinet. 6RISKS to HEALTH and SAFETY from INTENDED USEFrom personal exposure or hazardous reactions. Refer to OELs, flash points, etc., as appropriate. Are pregnant women, breast-feeding mothers especially at risk?May cause: skin irritation, eye irritation, irritation to mucous membranes and the upper respiratory tract;May be harmful if: absorbed through the skin, inhaled or swallowed.To the best of the manufacturers knowledge (Sigma-Aldrich) the chemical, physical and toxicological properties have not been thoroughly investigated but the data sheet quotes no toxicological values below 400mg/kg.OEL = MAKStability stableIncompatibilities strong oxidising agentsHazardous combustion or decomposition products carbon monoxide, carbon dioxide, nitrogen oxides.Hazardous polymerisation will not occur. 7CONCLUSIONS ABOUT RISKSIs level of risk acceptable? Can risk be prevented or reduced by change of substance/procedure? Are control measures necessary?Risk level is low and acceptable. 8CONTROL MEASURESAdditional to Good Chemical PracticeWear compatible chemically-resistant gloves and lab coat when weighing out in a closed microbalance. Make dilutions in class 2 safety cabinet. 9INSTRUCTION/TRAININGSpecify course(s) and/or special arrangements.None.  10MONITORINGPerformance of control measures, None Personal exposureHealth SurveillanceNone  11WASTE DISPOSAL PROCEDURE See School Server for Approved Procedure Document on specific Chemical Waste Disposal.Pour off aqueous solutions and autoclave with the rest of the tissue culture waste. 12REVIEWEnter the date or circumstances for review of assessment (maximum review interval 5 years)5 years. 13EMERGENCY ACTIONTO CONTROL HAZARDSTo stabilize situation eg spread absorbant on liquid spill; eliminate sources of ignition, etc.Max spillage equates to 10g therefore for spillage wear lab coat and rubber gloves. Sweep up, place in a bagand hold for waste disposal avoiding the raising of dust. Ventilate area and wash spill site after material pick up.For dissolved liquid spills absorb onto paper towelling and dispose of for autoclaving. Ventilate area and washspill site after material pick up.TO PROTECT PERSONNELEvacuation, protection for personnel involved in clean-up, Special First AidAvoid inhalation, contact with eyes, skin or clothing.If swallowed, wash out mouth with water provided the person is conscious, call a physician.If inhaled, remove to fresh air. If breathing becomes difficult call a physician.In case of contact, immediately wash skin with soap and copious amounts of water.In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.TO RENDER SITE OF EMERGENCY SAFEClean-up/decontaminationSee section 13. CONTACT PHONE 10.10.00 * Prefix T is used for Teaching Assessment Number. ** Please include amount of chemicals used and how. *** Hazdat No is the UNICOSHH datasheet report number. Biosciences No is the Biosciences data sheet number. 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