Advances in Systemic Cancer Therapy Alex A. Adjei

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Advances in Systemic Cancer Therapy

Alex A. Adjei

ESMO Summit Africa

February 13, 2017 Cape Town, RSA

?2016 MFMER | slide-1

No conflicts of interest

?2016 MFMER | slide-2

Cancer Cells Adapt to Stress

?2016 MFMER | slide-3

Strategies for Targeting Hallmarks of Cancer

?2016 MFMER | slide-4

Novel Therapeutics

? Targets - multiple

? Methods of Inhibiting Targets ? limited

? Chemical therapy ? Small molecule inhibitors ? Monoclonal Antibodies ? Chimeric Antibodies ? Antibody Drug Conjugates ? Vaccines ? Adoptive T cell transfer ? Chimeric Antigen Receptor T-cells ? RNAi ? Gene Therapy ? Viral Therapies ? Clustered regularly interspaced short palindromic

repeats (CRISPR)

?2016 MFMER | slide-5

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