Recent Advances and New Directions in Cancer Therapy”
10th Annual California Cancer Consortium Conference
"Recent Advances and New Directions in Cancer Therapy"
August 8-10, 2014
The Westin Pasadena Pasadena, CA
Presented by the California Cancer Consortium
University of California Davis Comprehensive Cancer Center, Sacramento, CA
City of Hope Comprehensive Cancer Center Duarte, CA
University of Southern California/ Norris Comprehensive Cancer Center
Los Angeles, CA
University of Pittsburgh Cancer Institute/UPMC Pittsburgh, PA
Barbara Ann Karmanos Comprehensive Cancer Center (Wayne State University), Detroit, MI
Penn State Hershey Cancer Institute (Penn State University), Hershey, PA
Program Chairs:
Primo Lara, Jr., M.D. | Edward Newman, Ph.D.
Steering Committee:
Chandra Belani, M.D. | Edward Chu, M.D. David Gandara, M.D. | Heinz-Josef Lenz, MD, Ph.D.
Patricia LoRusso, D.O. | Robert Morgan, M.D.
Sponsored by: THE MEDICAL EDUCATOR CONSORTIUM
Program Chairs
Primo Lara, Jr., M.D. Professor of Medicine University of California Davis School of Medicine Associate Director for Translational Research University of California Davis Comprehensive Cancer Center
Edward Newman, Ph.D. Associate Professor, Molecular Pharmacology Co-director, Analytical Pharmacology Core Facility City of Hope Comprehensive Cancer Center
Steering Committee
Chandra Belani, M.D. Miriam Beckner Distinguished Professor of Medicine Penn State Milton S. Hershey Medical Center Deputy Director Penn State Hershey Cancer Institute
Edward Chu, M.D. Professor and Chief of Hematology/ Oncology University of Pittsburgh School of Medicine Deputy Director, University of Pittsburgh Cancer Institute
David Gandara, M.D. Professor of Medicine University of California Davis School of Medicine Senior Advisor to the Director University of California Davis Comprehensive Cancer Center
Heinz-Josef Lenz, M.D., Ph.D. Professor of Medicine and Preventive Medicine, Section Head of GI Oncology University of Southern California, Keck School of Medicine Associate Director for Clinical Research, University of Southern California Norris Comprehensive Cancer Center
Patricia LoRusso, D.O. Professor of Medicine Wayne State University School of Medicine Director, Center for Experimental Therapeutics, Karmanos Cancer Institute
Robert Morgan, M.D. Professor of Medicine Co-director, Gynecological Cancers Program City of Hope Comprehensive Cancer Center
Distinguished Faculty
Leonard Appleman, M.D. Assistant Professor University of Pittsburgh School of Medicine University of Pittsburgh Cancer Institute
Chandra Belani, M.D. Miriam Beckner Distinguished Professor of Medicine Penn State Milton S. Hershey Medical Center Deputy Director Penn State Hershey Cancer Institute
Suzette Blanchard, Ph.D. Assistant Professor and Senior Biostatistician City of Hope Comprehensive Cancer Center
Alice Chen, M.D. Senior Investigator CTEP, National Cancer Institute
Helen Chew, M.D. Professor of Medicine University of California Davis School of Medicine
Diana Chingos, MS, MFA Patient Advocate University of Southern California and Young Survival Coalition
Tanya Dorff, M.D. Assistant Professor University of Southern California Keck School of Medicine Norris Comprehensive Cancer Center
Anthony El-Khoueiry, M.D. Assistant Professor University of Southern California Keck School of Medicine Norris Comprehensive Cancer Center
Stephen Forman, M.D. Francis and Kathleen McNamara Distinguished Chair in Hematology and Hematopoietic Cell Transplantation Co-leader, Hematologic Malignancies Program City of Hope Comprehensive Cancer Center
Paul Frankel, Ph.D. Senior Biostatistician, Division of Biostatistics, Department of Information Sciences Beckman Research Institute, City of Hope Comprehensive Cancer Center
Shirish Gadgeel, M.D. Leader, Thoracic Oncology Multidisciplinary Team, Barbara Ann Karmanos Cancer Center Associate Professor, Wayne State University School of Medicine
David Gandara, M.D. Professor of Medicine, University of California Davis School of Medicine Senior Advisor to the Director, University of California Davis Comprehensive Cancer Center
Susan Groshen, Ph.D. Professor of Medicine and Director, Biostatistics Core University Southern California Norris Comprehensive Cancer Center
Elisabeth Heath, M.D. Associate Professor of Oncology, Wayne State University School of Medicine Barbara Ann Karmanos Cancer Center
Brian Jonas, M.D., Ph.D. Assistant Professor, University of California Davis School of Medicine University of California Davis Comprehensive Cancer Center
Monica Joshi, M.D. Assistant Professor Penn State University Hershey School of Medicine, Penn State Hershey Cancer Institute
Karen Kelly, M.D. Professor of Medicine, University of California Davis School of Medicine Associate Director of Clinical Research, University of California Davis Comprehensive Cancer Center
Friedrich Knollman, M.D., Ph.D. Professor of Clinical Radiology, University of California Davis School of Medicine
Marianna Koczywas, M.D. Clinical Professor of Medicine City of Hope Comprehensive Cancer Center
Primo Lara, Jr., M.D. Professor of Medicine, University of California Davis School of Medicine Associate Director for Translational Research, University of California Davis Comprehensive Cancer Center
Heinz-Josef Lenz, M.D., Ph.D. Professor of Medicine and Preventive Medicine, Section Head of GI Oncology, University of Southern California, Keck School of Medicine Associate Director for Clinical Research University Southern California Norris Comprehensive Cancer Center
Tianhong Li, M.D., Ph.D. Assistant Professor, University of California Davis School of Medicine University of California Davis Comprehensive Cancer Center
Xin Liu, M.D. Assistant Professor Penn State University Hershey School of Medicine, Penn State Hershey Cancer Institute
Jeffrey Longmate, Ph.D. Professor and Director, Division of Biostatistics, Department of Information Sciences Beckman Research Institute, City of Hope Comprehensive Cancer Center
Patricia LoRusso, D.O. Professor of Medicine, Wayne State University School of Medicine Director, Center for Experimental Therapeutics Barbara Ann Karmanos Cancer Institute
Philip Mack, Ph.D. Associate Professor of Medicine, University of California Davis School of Medicine Director Cancer Molecular Pharmacology University of California Davis Comprehensive Cancer Center
Kim Margolin, M.D. Professor of Medicine University of Washington School of Medicine Fred Hutchinson Cancer Research Center Seattle Cancer Care Alliance
Robert Morgan, M.D. Professor of Medicine, Department of Medical Oncology and Therapeutics Research Co-director, Gynecological Cancers Program City of Hope Comprehensive Cancer Center
Edward Newman, Ph.D. Associate Professor, Molecular Pharmacology Co-director, Analytical Pharmacology Core Facility City of Hope Comprehensive Cancer Center
Amit Oza, M.D. Senior Staff Physician and Professor of Medicine Princess Margaret Hospital, University of Toronto School of Medicine
Sumanta Pal, M.D. Assistant Professor, Department of Medical Oncology and Therapeutics Research City of Hope Comprehensive Cancer Center
Philip Philip, M.D. Professor of Medicine, Wayne State University School of Medicine Clinical Professor of Oncology, Barbara Ann Karmanos Cancer Institute
Jacek Pinski, M.D, Ph.D. Associate Professor of Medicine Co-director, Prostate Cancer Research Program USC Norris Comprehensive Cancer Center
David Quinn, MBBS, Ph.D. Associate Professor and Head, Section of GU Medical Oncology, USC Keck School of Medicine Leader, Developmental Therapeutics Program University of Southern California Norris Comprehensive Cancer Center
Karen Reckamp, M.D. Co-director, Lung Cancer and Thoracic Oncology Program Associate Professor, Department of Medical Oncology and Therapeutics Research City of Hope Comprehensive Cancer Center
Jonathan Riess, M.D. Assistant Professor, University of California Davis School of Medicine University of California Davis Comprehensive Cancer Center
Lynda Roman, M.D. Associate Professor and Director Division of Obstetrics and Gynecology USC Keck School of Medicine USC Norris Comprehensive Cancer Center
Thomas Semrad, M.D. Assistant Professor, UC Davis School of Medicine University of California Davis Comprehensive Cancer Center,
Tanya Siddiqi, M.D. Assistant Professor, Department of Hematology & Hematopoietic Cell Transplantation City of Hope Comprehensive Cancer Center
George Somlo, M.D. Professor, Department of Medical Oncology and Therapeutics Research City of Hope Comprehensive Cancer Center
Timothy Synold, PharmD Co-director, Analytical Pharmacology Core Facility Associate Professor, Molecular Pharmacology City of Hope Comprehensive Cancer Center
Ahmad Tarhini, M.D. Associate Professor of Medicine, Clinical and Translational Science University of Pittsburgh School of Medicine
Joseph Tuscano, M.D. Professor of Medicine, University of California Davis School of Medicine University of California Davis Comprehensive Cancer Center
Przemyslaw Twardowski, M.D. Associate Professor, Department of Medical Oncology and Therapeutics Research City of Hope Comprehensive Cancer Center
Ulka Vaishampayan, M.D. Associate Professor of Medicine Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute
10th Annual California Cancer Consortium Conference
"Recent Advances and New Directions in Cancer Therapy"
Course Description
This conference aims to provide up-to-date information to the clinician regarding new advances in cancer biology, diagnosis, and treatment. It will bring together respected opinion leaders, practicing clinicians and scientists engaged in clinical cancer research to discuss the latest cancer diagnostic and therapeutic advances. Topics focus on the major cancers and drug development areas, including signal transduction/ CDK inhibition, angiogenesis inhibition, PI3K/ mTOR inhibition, antibody-drug conjugates, and immunotherapy, among others. This annual conference also includes interactive roundtable discussion forums with participation of cancer care experts from the California Cancer Consortium, and features renowned professionals from academia, patient advocacy, government, payer, industry, and business realms of cancer care.
Educational Objectives
After participating in this educational activity, you should be able to:
? Identify signaling and immunotherapeutic pathways that are involved in the growth and metastases of many individual tumor types, and identify specific opportunities for therapeutic intervention.
? Describe recent advances in the molecular phenotyping of cancer and relate these to the optimal management of your patients with cancer.
? Based on recent clinical trials, assess the efficacy of novel therapeutic strategies in the treatment of your patients with cancer.
? Discuss the new and emerging clinical trial designs that can test and validate new therapeutic strategies for cancer patients.
Target Audience
This program will be of interest to medical oncologists, hematologists, surgical oncologists, radiation oncologists, diagnostic radiologists, pulmonologists, urologists, gastroenterologists, pathologists, fellow and resident trainees, advanced care practitioners, registered nurses, physician assistants, clinical research coordinators, biostatisticians, and others involved in oncologic drug development and clinical care.
Needs Assessment
This course was developed in cooperation with the academic faculty and scientists belonging to the California Cancer Consortium to provide an annual in-depth exposure and review of new advances in cancer drug development, biology,
biomarkers, diagnosis, and therapy. The agenda and format was specifically designed to address knowledge gaps identified from prior course participant evaluations and unsolicited comments from practicing oncologists (from private practice, academia) as well as scientists involved in cancer clinical trials. This area of knowledge will be best addressed by an in-depth conference on systemic therapy of malignancies (both solid and hematologic), with ample time provided for interaction by attendees with expert faculty. It is expected that this course will enhance the clinical competence of clinicians in managing the care of the cancer patient, and subsequently improve patient outcomes.
ACCREDITATION
The Medical Educator Consortium is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
CREDIT HOURS The Medical Educator Consortium designates this educational activity for a maximum of 15 AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
DISCLOSURE The Medical Educator Consortium (MEC) adheres to the ACCME Standards for Commercial Support. All persons that will be in a position to control the content of the CME Activity are required to disclose all relevant financial relationships. Faculty disclosure forms outlining this information will be made available to all participants prior to educational activity. MEC has also implemented a mechanism to identify and resolve all conflicts of interest prior to the education activity being delivered to learners. The source of all support from commercial interests will also be disclosed to learners prior to the beginning of the educational activity.
Nursing Continuing Medical Education
Continuing Medical Education is acceptable for meeting RN continuing education requirements, as long as the course is AMA PRA Category 1 CreditsTM, and has been taken within the appropriate time frames.
CONFERENCE AGENDA
10th Annual California Cancer Consortium Conference
"Recent Advances and New Directions in Cancer Therapy"
Friday, August 8th, 2014
9:30 am - 12:30 pm 2:00 pm 3:30 pm 3:35 pm
Industry Advisory Board Block (by invitation only) Registration & Visit Exhibits Welcome and Introductions Pre-session Survey
Session 1: Inhibition of Signal Transduction and Angiogenesis Pathways Chairs: Primo Lara Jr., M.D., (UC Davis) and Edward Newman, Ph.D., (City of Hope)
3:40 pm
3:50 pm 3:55 pm
4:05 pm 4:10 pm
4:20 pm 4:25 pm
4:35 pm 4:40 pm
4:50 pm 5:00 pm
EGFR and Met Inhibitors: State of the Art Karen Reckamp, M.D., City of Hope Question-and-Answer Session PI3K/Akt and Related Pathways: Novel Therapeutics Leonard Appleman, University of Pittsburgh Question-and-Answer Session FGF and FGFR as Therapeutic Targets Thomas Semrad, M.D., UC Davis Question-and-Answer Session New Vascular/Angiogenesis -Targeted Therapies Tanya Dorff, M.D., USC Question-and-Answer Session mTOR inhibitors: Latest and Greatest Sumanta Pal, M.D., City of Hope Question-and-Answer Session Refreshment Break & Visit Exhibits
Session 2: Clinical Trial Design Chairs: Jeffrey Longmate, Ph.D., (City of Hope) and Paul Frankel, Ph.D., (City of Hope)
5:15 pm
5:25 pm 5:35 pm
5:45 pm 5:55 pm
6:05 pm 6:10 pm
6:20 pm 6:25 pm
Integration of New Clinical Trial Designs for Early Drug Development Suzette Blanchard, Ph.D., City of Hope Question-and-Answer Session Statistical Designs for Biomarker Development Susan Groshen, Ph.D., USC Question-and-Answer Session Rebiopsies and Serial Biopsies in Clinical Trials Diana Chingos, MS, MFA, USC Question-and-Answer Session Cancer Imaging in the Molecular-Targeted Era Friedrich Knollman, M.D., Ph.D. (UC Davis) Question-and-Answer Session Roundtable Discussion: Novel Paradigms in Early Drug Development Moderator: Jeffrey Longmate, Ph.D., City of Hope
Participants: Edward Newman, Ph.D.
Paul Frankel, Ph.D., Suzette Blanchard, Ph.D.
Susan Groshen, Ph.D., David Gandara, M.D.
Themes: (1) Phase 0 Trials
(2) Molecular Enrichment Strategies
(3) Cytostatic Therapy
Assessment
6:45 pm
Question-and-Answer Session
6:50 pm
Post-session Survey
7:00 pm - 9:00 pm
Wine and Cheese Welcome Reception & Visit Exhibits
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