Research Explorer | The University of Manchester



PRACTICE GUIDELINES FOR THE DIAGNOSIS AND MANAGEMENT OF ASPERGILLOSIS: 2016 UPDATE BY THE INFECTIOUS DISEASES SOCIETY OF AMERICA§Thomas F. Patterson1+*, George R. Thompson III2, David W. Denning3, Jay A. Fishman4, Susan Hadley5, Raoul Herbrecht6, Dimitrios P. Kontoyiannis7, Kieren A. Marr8, Vicki A. Morrison9, M. Hong Nguyen10, Brahm H. Segal11, William J. Steinbach12, David A. Stevens13, Thomas J. Walsh14, John R. Wingard15, Jo-Anne H. Young9, John E. Bennett16+Dedication: The panel dedicates these guidelines to the memory of our dear friend Susan Hadley MD, a core member of the Mycoses Study Group, caring physician, and wonderful colleague.1The University of Texas Health Science Center at San Antonio and South Texas Veterans Health Care System, San Antonio, TX2Departments of Medicine/Division of Infectious Diseases and Medical Microbiology and Immunology, University of California, Davis, CA3National Aspergillosis Centre, University Hospital of South Manchester, University of Manchester, United Kingdom.4Massachusetts General Hospital and Harvard Medical School, Boston, MA.5Department of Medicine Tufts Medical Center Boston, MA.§ It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient’s individual circumstances.6Department of Oncology and Hematology, Hautepierre Hospital, University of Strasbourg, Strasbourg, France7Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M.D. Anderson Cancer Center, Houston, TX8Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD9Department of Medicine/Division of Infectious Diseases, University of Minnesota, Minneapolis, MN 10Department of Medicine and Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA11Department of Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, and Departments of Medicine and Immunology, Roswell Park Cancer Institute, Buffalo, NY12Department of Pediatrics/Division of Pediatric Infectious Diseases, Department of Molecular Genetics and Microbiology, Duke University Medical Center Durham, NC13 California Institute for Medical Research, San Jose, CA14Departments of Medicine, Pediatrics, and Microbiology and Immunology, New York-Presbyterian Hospital -Weill Cornell Medical Center, New York15Department of Medicine, University of Florida, Gainesville, FL16Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MDRunning head: IDSA guidelines for aspergillosis+Thomas F. Patterson and John E. Bennett served as co-chairs for the IDSA Aspergillus Guidelines Committee*Corresponding Author:Thomas F. Patterson, MD, FACP, FIDSADivision of Infectious DiseasesProfessor of MedicineDirector, San Antonio Center for Medical MycologyThe University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive -- MSC 7881San Antonio TX 78229-3900Email: patterson@uthscsa.eduEXECUTIVE SUMMARYBackgroundAspergillus species continue to be an important cause of life-threatening infection in immunocompromised patients. This at-risk population is comprised of patients with prolonged neutropenia, allogeneic hematopoietic stem cell transplantation (HSCT), solid-organ transplantation, inherited or acquired immunodeficiencies, corticosteroid use, and others. This document constitutes the Guidelines of the Infectious Diseases Society of America (IDSA) for treatment of aspergillosis and replaces the Practice Guidelines for Aspergillus published in 2008. Since that publication, clinical studies evaluating new and existing therapies including combination therapy for the management of Aspergillus infection have been conducted and the data on use of non-culture-based biomarkers for diagnosing infection has been expanded. The objective of these Guidelines is to summarize the current evidence for treatment of different forms of aspergillosis. This document reviews guidelines for management of the three major forms of aspergillosis: invasive aspergillosis (IA); chronic (and saprophytic) forms of aspergillosis; and allergic forms of aspergillosis. Given the clinical importance of IA, emphasis is placed upon the diagnosis, treatment, and prevention of the different forms of invasive aspergillosis, including invasive pulmonary aspergillosis (IPA), Aspergillus sinusitis, disseminated aspergillosis, and several types of single organ IA. Summarized below are the 2016 recommendations for the management of aspergillosis. Due to the guidelines relevance to pediatrics, the guideline has been reviewed and endorsed by the Pediatric Infectious Diseases Society (PIDS). The panel followed a guideline development process that has been adopted by IDSA, which includes use of the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system, a systematic method of grading both the strength of the recommendation (weak or strong) and the quality of evidence (very low, low, moderate, and high) (Figure 1). The guidelines are not intended to replace clinical judgment in the management of individual patients. A detailed description of the methods, background, and evidence summaries that support each recommendation can be found in the full text of the guideline.EPIDEMIOLOGY AND RISK FACTORS FOR INFECTIONI. How can the most susceptible patients be protected from aspergillosis and which patients are most susceptible? What are sources of exposure to Aspergillus and how can exposure be decreased? Is environmental surveillance useful?Recommendations1.Hospitalized allogeneic HSCT recipients should be placed in a protected environment to reduce mould exposure (Strong Recommendation; Low Quality Evidence). 2.These precautions can be reasonably applied to other highly immunocompromised patients at increased risk for IA, such as patients receiving induction/re-induction regimens for acute leukemia (Strong Recommendation; Low Quality Evidence). 3.In hospitals in which a protected environment is not available, we recommend admission to a private room, no connection to construction sites, and not allowing plants or cut flowers to be brought into the patient’s room (Strong Recommendation; Low Quality Evidence:).4.We recommend reasonable precautions to reduce mould exposure among outpatients at high risk for IA, including avoidance of gardening, spreading mulch (compost) or close exposure to construction or renovation (Strong Recommendation; Low Quality Evidence). 5.Leukemia and transplant centers should perform regular surveillance of cases of invasive mould infection. An increase in incidence over baseline or the occurrence of invasive mould infections in patients who are not at high risk for such infections should prompt evaluation for a hospital source (Strong Recommendation; Low Quality Evidence). DIAGNOSIS OF ASPERGILLOSIS II. How can a diagnosis of IA be established?How should Aspergillus be identified and how does this influence management? Recommendation6.Until molecular tools are more widely used in clinical laboratories, we recommend that tissue and fluid specimens be submitted in adequate quantities for simultaneous histopathologic/cytologic and culture examination. In the case of isolates with atypical growth or concerns for resistance, species identification by molecular methods should be employed. (Strong Recommendation; High Quality Evidence).What is the diagnostic value of nucleic acid testing in clinical specimens?Recommendations7.There was debate among the committee members regarding the clinical utility of blood-based PCR in diagnosing IA and experts were not in agreement.? One group favored recommendations for PCR testing, based on publications validating its?role when used in conjunction with other tests such as antigen detection assays to diagnose IA and/or reduce pre-emptive antifungal usage.? The other group felt that PCR assays are promising, but could not be recommended for routine use in clinical practice at present due to the lack of conclusive validation for commercially available assays, the variety of?methodologies in the literature, and questions about the extent to which results assisted diagnosis.???8.As research in the area continues, we recommend that clinicians?choosing to?use PCR assays employ them carefully in the management of individual patients on a case-by-case basis.? Clinicians should be aware of the methodologies and performance?characteristics of the specific assay used, and interpret results accordingly.?When PCR assays are used, results should be considered in conjunction with other diagnostic tests and the clinical context (Strong Recommendation; Moderate Quality Evidence).?How should galactomannan (GM) and (1→3)-β-D-glucan be used for the diagnosis of aspergillosis? Recommendations9.Serum and BAL GM is recommended as an accurate marker for the diagnosis of IA in adult and pediatric patients when used in certain patient subpopulations (hematologic malignancy, HSCT) (Strong Recommendation; High Quality Evidence). 10.GM is not recommended for routine blood screening in patients receiving mould-active antifungal therapy or prophylaxis, but can be applied to bronchoscopy specimens from those patients (Strong Recommendation; High Quality Evidence). 11.GM is not recommended for screening in solid organ transplant recipients or patients with chronic granulomatous disease (CGD) (Strong Recommendation; High Quality Evidence). 12.Serum assays for (1→3)-β-D-glucan are recommended for diagnosing IA in high risk patients (hematologic malignancy, allogeneic HSCT), but are not specific for Aspergillus (Strong Recommendation; Moderate Quality Evidence).What is the approach to the radiographic diagnosis of IPA?Recommendations13.We recommend performing a chest computed tomographic (CT) scan whenever there is a clinical suspicion for IPA regardless of chest radiograph results (Strong Recommendation; High Quality Evidence). 14.Routine use of contrast during a chest CT scan for a suspicion of IPA is not recommended (Strong Recommendation; Moderate Quality Evidence). Contrast is recommended when a nodule or a mass is close to a large vessel (Strong Recommendation; Moderate Quality Evidence). 15.We suggest a follow-up chest CT-scan to assess the response of IPA to treatment after a minimum of two weeks of treatment; earlier assessment is indicated if the patient clinically deteriorates (Weak Recommendation; Low Quality Evidence). When a nodule is close to a large vessel, more frequent monitoring may be required (Weak Recommendation; Low Quality Evidence).What is the role of bronchoscopy in the diagnosis of IPA? Recommendation16.We recommend performing a bronchoscopy with bronchoalveolar lavage (BAL) in patients with a suspicion of IPA (Strong Recommendation; Moderate Quality Evidence) Significant comorbidities such as severe hypoxemia, bleeding, and platelet transfusion-refractory thrombocytopenia may preclude BAL. The yield of BAL is low for peripheral nodular lesions, so that percutaneous or endobronchial lung biopsy should be considered. We recommend the use of a standardized BAL procedure and sending the BAL sample for routine culture and cytology as well as non-culture-based methods (e.g. GM) (Strong Recommendation; Moderate Quality Evidence). III. What antifungal agents are available for the treatment and prophylaxis of IA including pharmacologic considerations and what is the role for susceptibility testing? Amphotericin B (AmB)Recommendations17.AmB deoxycholate and its lipid derivatives are appropriate options for initial and salvage therapy of Aspergillus infections when voriconazole cannot be administered. However, AmB deoxycholate should be reserved for use in resource-limited settings in which no alternative agents are available. Lipid formulations of AmB should be considered in settings in which azoles are contraindicated or not tolerated (Strong Recommendation; Moderate Quality Evidence).18.Aerosolized formulations of AmB may be considered as prophylaxis in patients with prolonged neutropenia (patients receiving induction/re-induction therapy for acute leukemia and allogeneic HSCT recipients following conditioning or during treatment of Graft versus Host Disease [GVHD]) and in lung transplant recipients (Weak Recommendation; Low Quality Evidence).EchinocandinsRecommendation19.Echinocandins are effective in salvage therapy (either alone or in combination) against IA, but we do not recommend their routine use as monotherapy for the primary treatment of IA (Strong Recommendation; Moderate Quality Evidence). TriazolesRecommendations20.Triazoles are preferred agents for treatment and prevention of IA in most patients (Strong Recommendation; High Quality Evidence). 21.For patients receiving triazole-based therapy for IA, prolonged azole prophylaxis, or other therapies for which drug interactions with azoles are anticipated, the committee recommends therapeutic drug monitoring (TDM) once the steady state has been reached. A moderate amount of data for itraconazole, voriconazole, and posaconazole suspension suggests this approach may be valuable in enhancing therapeutic efficacy, in evaluating therapeutic failures attributable to suboptimal drug exposures, and to minimize toxicities potentially attributable to the azoles. (Strong Recommendation; Moderate Quality Evidence). Further studies are needed to address whether TDM is helpful or necessary with the extended release or intravenous formulations of posaconazole or for isavuconazole.22.Clinicians should obtain serum trough drug levels for azole antifungal agents (itraconazole, voriconazole, posaconazole, and possibly isavuconazole) and for potentially interacting drugs such as cyclosporine, tacrolimus, and sirolimus (and other CYP450 3A4 substrates such as tyrosine kinase inhibitors) to optimize therapeutic efficacy and to avoid potential toxicities of both groups of agents (Strong Recommendation; Moderate Quality Evidence). Preclinical and Laboratory Assessment of Combination antifungal binations of polyenes or azoles with echinocandins suggest additive or synergistic effects in some pre-clinical studies.? However, variable test designs and conflicting results of preclinical and in vitro testing have led to uncertainty as to how to interpret the findings.? (Weak Recommendation; Low Quality Evidence).When should antifungal susceptibility testing be performed and how should results be interpreted and affect management?Recommendation24.Routine antifungal susceptibility testing of isolates recovered during initial infection is not recommended. Antifungal susceptibility testing of Aspergillus isolates using a reference method is reserved for patients suspected to have an azole resistant isolate, who are unresponsive to antifungal agents, or for epidemiological purposes (Strong Recommendation; Moderate Quality Evidence).INVASIVE SYNDROMES OF ASPERGILLUSIV. What are the recommended treatment regimens and adjunctive treatment measures for the various clinical presentation of IA?How should IPA be treated?Recommendations25.We recommend primary treatment with voriconazole (Strong Recommendation; High Quality Evidence). 26.Early initiation of antifungal therapy in patients with strongly suspected IPA is warranted while a diagnostic evaluation is conducted (Strong Recommendation; High Quality Evidence)27.Alternative therapies include liposomal AmB (Strong Recommendation; Moderate Quality Evidence), isavuconazole (Strong Recommendation; Moderate Quality Evidence), or other lipid formulations of AmB (Weak Recommendation; Low Quality Evidence). bination antifungal therapy with voriconazole and an echinocandin may be considered in select patients with documented IPA (Weak Recommendation; Moderate Quality Evidence).29.Primary therapy with an echinocandin is not recommended (Strong Recommendation; Moderate Quality Evidence). Echinocandins (micafungin or caspofungin) can be used in settings in which azole and polyene antifungals are contraindicated (Weak Recommendation; Moderate Quality Evidence).30.We recommend that treatment of IPA be continued for a minimum of 6-12 weeks, largely dependent on the degree and duration of immunosuppression, site of disease, and evidence of disease improvement (Strong Recommendation; Low Quality Evidence). 31.For patients with successfully treated IPA who require subsequent immunosuppression, secondary prophylaxis should be initiated to prevent recurrence (Strong Recommendation; Moderate Quality Evidence). Adjunctive measures and immunomodulation: When should withdrawal of immunosuppressive agents, or addition of colony stimulating factors (CSFs) or granulocyte transfusions be considered in the treatment of IA?Recommendations32.Reducing doses of, or eliminating altogether, immunosuppressive agents, when feasible, is advised as a component of anti-Aspergillus therapy (Strong Recommendation; Low Quality Evidence).33.Colony stimulating factors may be considered in neutropenic patients with diagnosed or suspected IA (Weak Recommendation; Low Quality Evidence). There is insufficient evidence regarding the value of G-CSF versus GM-CSF in this setting.34.Granulocyte transfusions can be considered for neutropenic patients with IA that is refractory or are unlikely to respond to standard therapy, and for an anticipated duration of more than one week (Weak Recommendation; Low Quality Evidence). 35.Recombinant interferon- is recommended as prophylaxis in CGD patients (Strong Recommendation; High Quality Evidence). Its benefit as adjunctive therapy for IA is unknown.36.Surgery for aspergillosis should be considered for localized disease that is easily accessible to debridement (e.g., invasive fungal sinusitis or localized cutaneous disease) (Strong Recommendation; Low Quality Evidence). The benefit for IA in other settings such as in the treatment of endocarditis, osteomyelitis or focal central nervous system (CNS) disease appears rational. Other indications are less clear and require consideration of the patient’s immune status, co-morbidities, confirmation of a single focus, and the risks of surgery.When is it safe to proceed with chemotherapy or transplantation in a patient with IA?Recommendations37.IA is not an absolute contraindication to additional chemotherapy or HSCT (Strong Recommendation; Moderate Quality Evidence).38.Decisions about when to proceed with additional chemotherapy or HSCT following the diagnosis of aspergillosis should involve both Infectious Diseases specialists and Hematologists/Oncologists. These decisions must consider the risk of progressive aspergillosis during periods of subsequent anti-neoplastic treatment versus the risk of death from the underlying malignancy if this treatment is delayed (Strong Recommendation; Low Quality Evidence).What approaches are needed for refractory or progressive aspergillosis (salvage therapy)?Recommendations39.We recommend an individualized approach that takes into consideration the rapidity, severity, extent of infection, patient co-morbidities, and to exclude the emergence of a new pathogen (Strong Recommendation; Low Quality Evidence). The general strategies for salvage therapy typically include, (i) changing the class of antifungal; (ii) tapering or reversal of underlying immunosuppression when feasible, and (iii) surgical resection of necrotic lesions in selected cases.40. In the context of salvage therapy, an additional antifungal agent may be added to current therapy, or combination antifungal drugs from different classes other than those in the initial regimen may be used (Weak Recommendation; Moderate Quality Evidence).41.In patients currently receiving an antifungal and exhibiting an adverse event attributable to this agent, we recommend changing to an alternative class of antifungal, or the use of an alternative agent with a non-overlapping side-effect profile (Strong Recommendation; Low Quality Evidence).42.For salvage therapy, agents include lipid formulations of AmB, micafungin, caspofungin, posaconazole or itraconazole. The use of a triazole as salvage therapy should take into account prior antifungal therapy, host factors, pharmacokinetic considerations, and possible antifungal resistance (Strong Recommendation; Moderate Quality Evidence).How can biomarkers be used to assess patient response to therapy?Recommendations43.Serial monitoring of serum GM can be used in the appropriate patient subpopulations (hematologic malignancy, HSCT) who have an elevated GM at baseline to monitor disease progression, therapeutic response, and predict outcome (Strong Recommendation; Moderate Quality Evidence). 44.(1→3)-β-D-glucan has not been extensively studied in IA to predict outcome (Weak Recommendation; Low Quality Evidence).What are the recommended treatments for pediatric patients with aspergillosis?Recommendation45.Treatment of aspergillosis in children uses the same recommended therapies as in adult patients, however the dosing is different and for some antifungals is unknown (Strong Recommendation; High Quality Evidence).What are treatment options for aspergillosis of the airways in transplant and nontransplant recipients and how does it differ from IPA?Recommendations46.Saprophytic forms of tracheobronchial aspergillosis (TBA) do not require antifungal treatment except for symptomatic or immunosuppressed patients. Treatment includes bronchoscopic removal of mucoid impaction. Mould-active triazole agents are recommended for immunocompromised patients in whom the possibility of invasive disease cannot be eliminated (Strong Recommendation; Moderate Quality Evidence) 47.Bronchocentric granulomatosis is treated in the same fashion as allergic bronchopulmonary aspergillosis (ABPA) (Strong Recommendation; Low Quality Evidence). 48.Invasive forms of TBA are treated with a mould-active triazole or intravenous lipid formulations of AmB (Strong Recommendation; Moderate Quality Evidence). We also recommend minimization or reversal of underlying immunosuppression when feasible, and bronchoscopic debridement of airway lesions in selected cases (Strong Recommendation; Low Quality Evidence).49.In lung transplant recipients, we recommend treatment with a systemic anti-mould antifungal for TBA, including saprophytic forms. We also recommend adjunctive inhaled AmB in the setting of TBA associated with anastomotic endobronchial ischemia or ischemic reperfusion injury due to airway ischemia associated with lung transplantation (Strong Recommendation; Moderate Quality Evidence). Duration of antifungal therapy is at least 3 months or until TBA is completely resolved, whichever is longer. MANAGEMENT OF EXTRAPULMONARY ASPERGILLOSISWhat are the treatment considerations for CNS aspergillosis?Recommendation50.We recommend voriconazole as primary therapy for CNS aspergillosis (Strong Recommendation; Moderate Quality Evidence). Lipid formulations of AmB are reserved for those intolerant or refractory to voriconazole (Strong Recommendation; Moderate Quality Evidence).How is Aspergillus endophthalmitis treated?Recommendation51.We recommend that Aspergillus endophthalmitis be treated with systemic oral or intravenous voriconazole plus intravitreal voriconazole or intravitreal AmB deoxycholate (Strong Recommendation; Weak Quality Evidence).What is the role of surgery in aspergillosis of the paranasal sinuses?Recommendation52.We recommend that both surgery and either systemic voriconazole or a lipid formulation of AmB be used in invasive Aspergillus fungal sinusitis but that surgical removal alone can be used to treat Aspergillus fungal ball of the paranasal sinus. Enlargement of the sinus ostomy may be needed to improve drainage and prevent recurrence (Strong Recommendation; Moderate Quality Evidence). What are the treatment recommendations for Aspergillus endocarditis, pericarditis, and myocarditis?Recommendation53.In Aspergillus endocarditis, we recommend early surgical intervention combined with antifungal therapy in attempts to prevent embolic complications and valvular decompensation (Strong Recommendation; Moderate Quality Evidence). Voriconazole or a lipid formulation of AmB is recommended as initial therapy (Strong Recommendation; Low Quality Evidence). Following surgical replacement of an infected valve, lifelong antifungal therapy should be considered (Strong Recommendation; Low Quality Evidence).What are the treatment recommendations for Aspergillus osteomyelitis and septic arthritis?Recommendation54.Surgical intervention is recommended, where feasible, for management of Aspergillus osteomyelitis and arthritis, combined with voriconazole (Strong Recommendation; Moderate Quality Evidence).What are the treatment recommendations for cutaneous aspergillosis? Recommendations55.As cutaneous lesions may reflect disseminated infection, we recommend treatment with voriconazole in addition to evaluation for a primary focus of infection (Strong Recommendation; Low Quality Evidence). 56.In cases of aspergillosis in burns or massive soft tissue wounds, surgical debridement is recommended, in addition to antifungal therapy (Strong Recommendation; Moderate Quality Evidence). What are the treatment recommendations for Aspergillus peritonitis?Recommendation57.We recommend prompt peritoneal dialysis catheter removal accompanied by systemic antifungal therapy with voriconazole (Strong Recommendation; Weak Quality Evidence). What are the treatment recommendations for esophageal, gastrointestinal, and hepatic aspergillosis?Recommendations58.We suggest voriconazole and surgical consultation in attempts to prevent complications of hemorrhage, perforation, obstruction or infarction (Weak Recommendation; Low Quality Evidence). 59.We suggest antifungal therapy with voriconazole or a lipid formulation of AmB as initial therapy for hepatic aspergillosis. For extrahepatic or perihepatic biliary obstruction, or localized lesions that are refractory to medical therapy, surgical intervention is should be considered (Weak Recommendation; Low Quality Evidence). What are the treatment recommendations for renal aspergillosis?Recommendation60.We suggest a combined approach of medical and urologic management for renal aspergillosis. Obstruction of one or both ureters should be managed with decompression if possible and local instillation of AmB deoxycholate. Parenchymal disease is best treated with voriconazole (Weak Recommendation; Low Quality Evidence).What are the treatment regimens for Aspergillus ear infections?Recommendations61.Noninvasive Aspergillus otitis externa, also called otomycosis, is treated by thorough mechanical cleansing of the external auditory canal followed by topical antifungals or boric acid (Strong Recommendation; Moderate Quality Evidence).62.We recommend that clinicians treat IA of the ear with a prolonged course of systemic voriconazole, usually combined with surgery (Strong Recommendation; Low Quality Evidence). What are the treatment recommendations for Aspergillus keratitis?Recommendation63.We recommend that clinicians treat Aspergillus keratitis with topical natamycin 5% ophthalmic suspension or topical voriconazole (Strong Recommendation; Moderate Quality Evidence).How should Aspergillus bronchitis be diagnosed and treated in the non-transplant population?Recommendations64.We suggest the diagnosis of aspergillus bronchitis in non-transplant patients be confirmed by detection of Aspergillus spp. in respiratory secretions, usually sputum, with both PCR and GM on respiratory samples being much more sensitive than culture (Weak Recommendation; Low Quality Evidence).65.??? We suggest treatment with oral itraconazole or voriconazole with therapeutic drug monitoring (Weak Recommendation; Low Quality Evidence).V. What are the recommended prophylactic regimens: who should receive them and how should breakthrough infection be managed?PROPHYLAXIS OF IAIn what patients should antifungal prophylaxis against aspergillosis be used? Recommendation66.We recommend prophylaxis with posaconazole (Strong Recommendation; High Quality Evidence), voriconazole (Strong Recommendation; Moderate Quality Evidence), and/or micafungin (Weak Recommendation; Low Quality Evidence) during prolonged neutropenia for those who are at high risk for IA (Strong Recommendation; High Quality Evidence). Prophylaxis with caspofungin is also probably effective (Weak Recommendation; Low Quality Evidence). Prophylaxis with itraconazole is effective, but therapy may be limited by absorption and tolerability (Strong Recommendation; Moderate Quality Evidence). Triazoles should not be co-administered with other agents known to have potentially toxic levels with concurrent triazole coadministration (such as vinca alkaloids, and others) (Strong Recommendation; Moderate Quality Evidence).What are the recommended prophylactic regimens for patients with GVHD? Recommendations67.We recommend prophylaxis with posaconazole for allogeneic HSCT recipients with GVHD who are at high risk for IA (Strong Recommendation; High Quality Evidence). Prophylaxis with other mould-active azoles is also effective. Voriconazole is commonly used for prophylaxis against IA in high risk patients but did not show improved survival in clinical trials (Strong Recommendation; Moderate Quality Evidence). Prophylaxis with itraconazole is limited by tolerability and absorption (Strong Recommendation; High Quality Evidence). 68.We recommend continuation of antifungal prophylaxis throughout the duration of immunosuppression in patients with chronic immunosuppression associated with GVHD (corticosteroid equivalent of >1 mg/kg/day of prednisone for >2 weeks and/or the use of other anti-GVHD therapies, such as lymphocyte depleting agents, or tumor necrosis factor α (TNF-α) inhibition, for refractory GVHD) (Strong Recommendation; High Quality Evidence).What are the recommendations for antifungal prophylaxis in lung transplant patients?Recommendations69.We recommend antifungal prophylaxis with either a systemic triazole such as voriconazole or itraconazole or an inhaled AmB product for 3 to 4 months after lung transplant (Strong Recommendation; Moderate Quality Evidence).70.Systemic voriconazole or itraconazole is suggested over inhaled amphotericin B for lung transplant recipients with mould colonization pre- or post- lung transplantation, mould infections found in explanted lungs, fungal infections in the sinus, and single lung transplant recipients. (Weak Recommendation; Low Quality Evidence).71.We recommend reinitiating antifungal prophylaxis for lung transplant recipients receiving immunosuppression augmentation with either thymoglobulin, alemtuzumab, or high dose corticosteroids (Strong Recommendation; Moderate Quality Evidence).What are the recommendations for antifungal prophylaxis in non-lung solid organ transplant recipients?Recommendation72.We recommend prophylactic strategies in solid organ transplant recipients based on the institutional epidemiology of infection and assessment of individual risk factors (Strong Recommendation; Low Quality Evidence).? Prospective trials are lacking to address the need for routine anti-Aspergillus prophylaxis other than for lung transplant recipients.? Individual risk factors have been identified in cardiac (pre-transplant colonization, reoperation, cytomegalovirus (CMV) infection, renal dysfunction, institutional outbreak), liver (fulminant hepatic failure, reoperation, retransplantation or renal failure), and others with institutional outbreaks or prolonged or high-dose corticosteroid use.? In such patients, the optimal duration of prophylaxis is not known.? MANAGEMENT OF BREAKTHROUGH INFECTION How should breakthrough aspergillosis be managed?Recommendation73.We suggest an individualized approach that takes into consideration the rapidity and severity of infection and local epidemiology. As principles, we recommend an aggressive and prompt attempt to establish a specific diagnosis with bronchoscopy and/or CT-guided biopsy for peripheral lung lesions. Documentation of serum azole levels should be verified if TDM is available for patients receiving mould-active triazoles. Antifungal therapy should be empirically changed to an alternative class of antifungal with Aspergillus activity. Other considerations include reduction of underlying immunosuppression if feasible, and susceptibility testing of any Aspergillus isolates recovered from the patient (Weak Recommendation; Moderate Quality Evidence).VI. When should patients be treated empirically?What strategies are recommended for empirical and pre-emptive strategies in allogeneic HSCT recipients and patients treated for acute myelogenous leukemia (AML)? Recommendations74.Empirical antifungal therapy is recommended for high-risk patients with prolonged neutropenia who remain persistently febrile despite broad-spectrum antibiotic therapy. Antifungal options include a lipid formulation of AmB (Strong Recommendation; High Quality Evidence), an echinocandin (caspofungin or micafungin) (Strong Recommendation; High Quality Evidence), or voriconazole (Strong Recommendation; Moderate Quality Evidence). 75.Empirical antifungal therapy is not recommended for patients who are anticipated to have short durations of neutropenia (duration of neutropenia <10 days), unless other findings indicate a suspected invasive fungal infection (Strong Recommendation; Moderate Quality Evidence).76.The use of serum or BAL fungal biomarkers such as GM or (1→3)-β-D-glucan to guide antifungal therapy in asymptomatic or febrile high risk patients (often referred to as pre-emptive or biomarker-driven antifungal therapy) can reduce unnecessary antifungal therapy. The pre-emptive approach can result in more documented cases of invasive aspergillosis without compromise in survival and can be used as an alternative to empirical antifungal therapy (Strong Recommendation; Moderate Quality Evidence).77.Early initiation of antifungal therapy in patients with strongly suspected IPA is warranted while a diagnostic evaluation is conducted (Strong Recommendation; Moderate Quality Evidence). 78.Management of suspected or documented breakthrough IPA in the context of mould-active azole prophylaxis or empirical suppressive therapy is not defined by clinical trial data but a switch to another drug class is suggested (Weak Recommendation; Low Quality Evidence). How do lung transplant recipients differ from other immunosuppressed patients in management of suspected IPA?Recommendations79.In lung transplant recipients not on anti-mould prophylaxis, we suggest pre-emptive therapy with an anti-mould antifungal for asymptomatic patients with Aspergillus colonization of the airways within 6 months of lung transplantation or within 3 months of receiving immunosuppression augmentation for rejection (Weak Recommendation; Moderate Quality Evidence).80.Six months after lung transplantation and in the absence of recent immunosuppression augmentation for rejection, it may be prudent to withhold antifungal therapy for Aspergillus airway colonization (i.e., Aspergillus respiratory cultures in the absence of clinical features that suggest disease, such as compatible symptoms, or bronchoscopic, histopathologic and/or radiographic findings) (Weak Recommendation; Low Quality Evidence).CHRONIC AND SAPROPHYTIC SYNDROMES OF ASPERGILLUSVII. How should chronic aspergillosis, allergic or non-invasive syndromes be managed?How can chronic cavitary pulmonary aspergillosis (CCPA) be diagnosed and treated?Recommendations81.??The diagnosis of CCPA requires: (1) 3 months of chronic pulmonary symptoms or chronic illness or progressive radiographic abnormalities, with cavitation, pleural thickening, peri-cavitary infiltrates and sometimes a fungal ball; (2) Aspergillus IgG antibody elevated or other microbiological data; and (3) no or minimal immunocompromise, usually with one or more underlying pulmonary disorders. The Aspergillus IgG antibody test is the most sensitive microbiological test (Strong Recommendation; Moderate Quality Evidence). Sputum Aspergillus PCR testing is more sensitive than culture (Weak Recommendation; Moderate Quality Evidence).82.Patients with CCPA without pulmonary symptoms, weight loss or significant fatigue, and those without major impairment of pulmonary function or gradual loss of pulmonary function may be observed without antifungal therapy and followed every 3-6 months (Weak Recommendation; Low Quality Evidence).83. Patients with CCPA and either pulmonary or general symptoms or progressive loss of lung function or radiographic progression should be treated with a minimum of 6 months of antifungal therapy (Strong Recommendation; Low Quality Evidence).84. Oral itraconazole and voriconazole are the preferred oral antifungal agents (Strong Recommendation; High Quality Evidence); posaconazole is a useful third-line agent for those with adverse events or clinical failure (Strong Recommendation; Moderate Quality Evidence).85.Hemoptysis may be managed with oral tranexamic acid (Weak Recommendation; Low Quality Evidence), bronchial artery embolization (Strong Recommendation; Moderate Quality Evidence) or antifungal therapy to prevent recurrence (Strong Recommendation; Low Quality Evidence). Patients failing these measures may require surgical resection (Weak Recommendation; Moderate Quality Evidence). 86.In those who fail therapy, who develop triazole resistance and/or have adverse events, intravenous micafungin (Weak Recommendation; Low Quality Evidence), caspofungin (Weak Recommendation; Low Quality Evidence), or amphotericin B (Weak Recommendation; Low Quality Evidence) yield some responses. Treatment may need to be prolonged.87.Surgical resection is an option for some patients with localized disease, unresponsive to medical therapy, including those with pan-azole resistant A. fumigatus infection or persistent hemoptysis despite bronchial artery embolization (Strong Recommendation; Moderate Quality Evidence). The outcomes from surgery are less favorable than those with single aspergilloma, and a careful risk assessment prior to surgical intervention is required. 88.In those with progressive disease, long term, even life-long antifungal therapy may be required to control disease (Weak Recommendation; Low Quality Evidence), with continual monitoring for toxicity and resistance.What are the management options for an Aspergillus fungal ball of the lung (aspergilloma)?Recommendations89.Asymptomatic patients with a single aspergilloma and no progression of the cavity size over 6-24 months should continue to be observed (Strong Recommendation; Moderate Quality Evidence).90.Patients with symptoms, especially significant hemoptysis, with a single aspergilloma, should have it resected, assuming that there are no contraindications (Strong Recommendation; Moderate Quality Evidence).91.Peri/post-operative antifungal therapy is not routinely required, but if the risk of surgical spillage of the aspergilloma is moderate (related to location and morphology of the cavity) antifungal therapy with voriconazole (or another mould active azole) or an echinocandin is suggested to prevent Aspergillus empyema (Weak Recommendation; Low Quality Evidence). ALLERGIC SYNDROMES OF ASPERGILLUSHow is ABPA identified and managed, in patients with asthma and cystic fibrosis (CF)?Recommendations92.Elevated Aspergillus IgE and total IgE are recommended to establish the diagnosis and are useful for screening (Strong Recommendation; High Quality Evidence).93.We suggest treating symptomatic asthmatic patients with bronchiectasis or mucoid impaction, despite oral or inhaled corticosteroid therapy, with oral itraconazole therapy with therapeutic drug monitoring (Weak Recommendation; Low Quality Evidence).94.In CF patients with frequent exacerbations and/or falling FEV1, we suggest treating with oral itraconazole to minimize corticosteroid use with therapeutic drug monitoring, and consideration of other mould-active azole therapy if therapeutic levels cannot be achieved. (Weak Recommendation; Low Quality Evidence).What is the medical management of allergic fungal rhinosinusitis caused by Aspergillus spp.?Recommendations95.We recommend establishing the diagnosis of allergic fungal rhinosinusitis (AFRS) in patients with nasal polyposis and thick eosinophilic mucin by visualizing hyphae in mucus, which is supported by a positive anti-Aspergillus IgE serum antibody assay or skin prick test (where available) (Strong Recommendation; Moderate Quality Evidence). 96.We recommend polypectomy and sinus washout as the optimal means of symptom control and inducing remission, however relapse is frequent (Strong Recommendation; Moderate Quality Evidence).97.We recommend the use of topical nasal steroids to reduce symptoms and increase time to relapse, especially if given after surgery (Strong Recommendation; Moderate Quality Evidence).98.We suggest oral antifungal therapy using mould-active triazoles for refractory infection and/or rapidly relapsing disease, although this approach is only partially effective (Weak Recommendation; Low Quality Evidence).INTRODUCTIONIA remains a major cause of morbidity and mortality in high risk immunocompromised patients. Additionally, chronic and allergic syndromes due to Aspergillus are recognized to affect an even greater number of additional patients. In recent years, the clinical evidence for the diagnosis and management of patients with Aspergillus syndromes has vastly increased. New agents and formulations along with studies for the use of older agents are available for treating patients with these infections, and new diagnostic tools have increased the ability to diagnose these infections in a timely manner. This document constitutes the Guidelines of the Infectious Diseases Society of America (IDSA) for treatment of aspergillosis. These guidelines replace the Practice Guidelines for Aspergillus published in 2008 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYWxzaDwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl

Y051bT4xNzE8L1JlY051bT48RGlzcGxheVRleHQ+WzFdPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjE3MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDEy

MjAzOTg1Ij4xNzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPldhbHNo

LCBULiBKLjwvYXV0aG9yPjxhdXRob3I+QW5haXNzaWUsIEUuIEouPC9hdXRob3I+PGF1dGhvcj5E

ZW5uaW5nLCBELiBXLjwvYXV0aG9yPjxhdXRob3I+SGVyYnJlY2h0LCBSLjwvYXV0aG9yPjxhdXRo

b3I+S29udG95aWFubmlzLCBELiBQLjwvYXV0aG9yPjxhdXRob3I+TWFyciwgSy4gQS48L2F1dGhv

cj48YXV0aG9yPk1vcnJpc29uLCBWLiBBLjwvYXV0aG9yPjxhdXRob3I+U2VnYWwsIEIuIEguPC9h

dXRob3I+PGF1dGhvcj5TdGVpbmJhY2gsIFcuIEouPC9hdXRob3I+PGF1dGhvcj5TdGV2ZW5zLCBE

LiBBLjwvYXV0aG9yPjxhdXRob3I+dmFuIEJ1cmlrLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+V2lu

Z2FyZCwgSi4gUi48L2F1dGhvcj48YXV0aG9yPlBhdHRlcnNvbiwgVC4gRi48L2F1dGhvcj48YXV0

aG9yPkluZmVjdGlvdXMgRGlzZWFzZXMgU29jaWV0eSBvZiwgQW1lcmljYTwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlBlZGlhdHJpYyBPbmNvbG9neSBCcmFu

Y2gsIE5hdGlvbmFsIENhbmNlciBJbnN0aXR1dGUsIEJldGhlc2RhLCBNYXJ5bGFuZCwgVVNBLjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlRyZWF0bWVudCBvZiBhc3BlcmdpbGxvc2lzOiBj

bGluaWNhbCBwcmFjdGljZSBndWlkZWxpbmVzIG9mIHRoZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNv

Y2lldHkgb2YgQW1lcmljYTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluIEluZmVjdCBEaXM8

L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGluZmVjdGlvdXMgZGlzZWFzZXMg

OiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlvbiBvZiB0aGUgSW5mZWN0aW91cyBEaXNlYXNlcyBTb2Np

ZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRs

ZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2xpbi4g

SW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5DbGluIEluZmVjdCBEaXM8L2FiYnItMj48L3Bl

cmlvZGljYWw+PHBhZ2VzPjMyNy02MDwvcGFnZXM+PHZvbHVtZT40Njwvdm9sdW1lPjxudW1iZXI+

MzwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy90aGVyYXBldXRp

YyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kcnVnIHRoZXJhcHkvbWljcm9i

aW9sb2d5Lyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMsIEFsbGVyZ2lj

IEJyb25jaG9wdWxtb25hcnkvZHJ1ZyB0aGVyYXB5L21pY3JvYmlvbG9neS8qdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBEaXNlYXNlcywgRnVu

Z2FsL2RydWcgdGhlcmFweS9taWNyb2Jpb2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MjAwODwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAxPC9kYXRlPjwv

cHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00

ODM4IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xODE3NzIyNTwvYWNjZXNzaW9uLW51

bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1

Ym1lZC8xODE3NzIyNTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTA4Ni81MjUyNTg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3Jk

PjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYWxzaDwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl

Y051bT4xNzE8L1JlY051bT48RGlzcGxheVRleHQ+WzFdPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjE3MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDEy

MjAzOTg1Ij4xNzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPldhbHNo

LCBULiBKLjwvYXV0aG9yPjxhdXRob3I+QW5haXNzaWUsIEUuIEouPC9hdXRob3I+PGF1dGhvcj5E

ZW5uaW5nLCBELiBXLjwvYXV0aG9yPjxhdXRob3I+SGVyYnJlY2h0LCBSLjwvYXV0aG9yPjxhdXRo

b3I+S29udG95aWFubmlzLCBELiBQLjwvYXV0aG9yPjxhdXRob3I+TWFyciwgSy4gQS48L2F1dGhv

cj48YXV0aG9yPk1vcnJpc29uLCBWLiBBLjwvYXV0aG9yPjxhdXRob3I+U2VnYWwsIEIuIEguPC9h

dXRob3I+PGF1dGhvcj5TdGVpbmJhY2gsIFcuIEouPC9hdXRob3I+PGF1dGhvcj5TdGV2ZW5zLCBE

LiBBLjwvYXV0aG9yPjxhdXRob3I+dmFuIEJ1cmlrLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+V2lu

Z2FyZCwgSi4gUi48L2F1dGhvcj48YXV0aG9yPlBhdHRlcnNvbiwgVC4gRi48L2F1dGhvcj48YXV0

aG9yPkluZmVjdGlvdXMgRGlzZWFzZXMgU29jaWV0eSBvZiwgQW1lcmljYTwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlBlZGlhdHJpYyBPbmNvbG9neSBCcmFu

Y2gsIE5hdGlvbmFsIENhbmNlciBJbnN0aXR1dGUsIEJldGhlc2RhLCBNYXJ5bGFuZCwgVVNBLjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlRyZWF0bWVudCBvZiBhc3BlcmdpbGxvc2lzOiBj

bGluaWNhbCBwcmFjdGljZSBndWlkZWxpbmVzIG9mIHRoZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNv

Y2lldHkgb2YgQW1lcmljYTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluIEluZmVjdCBEaXM8

L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGluZmVjdGlvdXMgZGlzZWFzZXMg

OiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlvbiBvZiB0aGUgSW5mZWN0aW91cyBEaXNlYXNlcyBTb2Np

ZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRs

ZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2xpbi4g

SW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5DbGluIEluZmVjdCBEaXM8L2FiYnItMj48L3Bl

cmlvZGljYWw+PHBhZ2VzPjMyNy02MDwvcGFnZXM+PHZvbHVtZT40Njwvdm9sdW1lPjxudW1iZXI+

MzwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy90aGVyYXBldXRp

YyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kcnVnIHRoZXJhcHkvbWljcm9i

aW9sb2d5Lyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMsIEFsbGVyZ2lj

IEJyb25jaG9wdWxtb25hcnkvZHJ1ZyB0aGVyYXB5L21pY3JvYmlvbG9neS8qdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBEaXNlYXNlcywgRnVu

Z2FsL2RydWcgdGhlcmFweS9taWNyb2Jpb2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MjAwODwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAxPC9kYXRlPjwv

cHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00

ODM4IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xODE3NzIyNTwvYWNjZXNzaW9uLW51

bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1

Ym1lZC8xODE3NzIyNTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTA4Ni81MjUyNTg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3Jk

PjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA [1] and incorporate new clinical evidence in the recommendations. The objective of these Guidelines is to summarize the current evidence for treatment of different forms of aspergillosis. The panel followed the GRADE framework as adopted by the IDSA. In the recommendation section which follows, the panel answered a series of broad questions for managing syndromes of aspergillosis and the background and evidence for the recommendations are presented: I. How can the most susceptible patients be protected from aspergillosis and which patients are most susceptible? II. How can a diagnosis of IA be established?III. What antifungal agents are available for the treatment and prophylaxis of IA including pharmacologic considerations and role for susceptibility testing?IV. What are the recommended treatment regimens and adjunctive treatment measures for the various clinical presentations of IA?V. What are the recommended prophylactic regimens: who should receive them and how should breakthrough infection be managed?VI. When should patients be treated empirically?VII. How should chronic aspergillosis, allergic or non-invasive syndromes be managed?METHODOLOGYPanel CompositionThe most recent version of the IDSA guidelines on the management of patients with aspergillosis was published in 2008 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYWxzaDwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl

Y051bT4xNzE8L1JlY051bT48RGlzcGxheVRleHQ+WzFdPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjE3MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDEy

MjAzOTg1Ij4xNzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPldhbHNo

LCBULiBKLjwvYXV0aG9yPjxhdXRob3I+QW5haXNzaWUsIEUuIEouPC9hdXRob3I+PGF1dGhvcj5E

ZW5uaW5nLCBELiBXLjwvYXV0aG9yPjxhdXRob3I+SGVyYnJlY2h0LCBSLjwvYXV0aG9yPjxhdXRo

b3I+S29udG95aWFubmlzLCBELiBQLjwvYXV0aG9yPjxhdXRob3I+TWFyciwgSy4gQS48L2F1dGhv

cj48YXV0aG9yPk1vcnJpc29uLCBWLiBBLjwvYXV0aG9yPjxhdXRob3I+U2VnYWwsIEIuIEguPC9h

dXRob3I+PGF1dGhvcj5TdGVpbmJhY2gsIFcuIEouPC9hdXRob3I+PGF1dGhvcj5TdGV2ZW5zLCBE

LiBBLjwvYXV0aG9yPjxhdXRob3I+dmFuIEJ1cmlrLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+V2lu

Z2FyZCwgSi4gUi48L2F1dGhvcj48YXV0aG9yPlBhdHRlcnNvbiwgVC4gRi48L2F1dGhvcj48YXV0

aG9yPkluZmVjdGlvdXMgRGlzZWFzZXMgU29jaWV0eSBvZiwgQW1lcmljYTwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlBlZGlhdHJpYyBPbmNvbG9neSBCcmFu

Y2gsIE5hdGlvbmFsIENhbmNlciBJbnN0aXR1dGUsIEJldGhlc2RhLCBNYXJ5bGFuZCwgVVNBLjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlRyZWF0bWVudCBvZiBhc3BlcmdpbGxvc2lzOiBj

bGluaWNhbCBwcmFjdGljZSBndWlkZWxpbmVzIG9mIHRoZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNv

Y2lldHkgb2YgQW1lcmljYTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluIEluZmVjdCBEaXM8

L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGluZmVjdGlvdXMgZGlzZWFzZXMg

OiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlvbiBvZiB0aGUgSW5mZWN0aW91cyBEaXNlYXNlcyBTb2Np

ZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRs

ZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2xpbi4g

SW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5DbGluIEluZmVjdCBEaXM8L2FiYnItMj48L3Bl

cmlvZGljYWw+PHBhZ2VzPjMyNy02MDwvcGFnZXM+PHZvbHVtZT40Njwvdm9sdW1lPjxudW1iZXI+

MzwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy90aGVyYXBldXRp

YyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kcnVnIHRoZXJhcHkvbWljcm9i

aW9sb2d5Lyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMsIEFsbGVyZ2lj

IEJyb25jaG9wdWxtb25hcnkvZHJ1ZyB0aGVyYXB5L21pY3JvYmlvbG9neS8qdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBEaXNlYXNlcywgRnVu

Z2FsL2RydWcgdGhlcmFweS9taWNyb2Jpb2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MjAwODwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAxPC9kYXRlPjwv

cHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00

ODM4IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xODE3NzIyNTwvYWNjZXNzaW9uLW51

bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1

Ym1lZC8xODE3NzIyNTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTA4Ni81MjUyNTg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3Jk

PjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYWxzaDwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl

Y051bT4xNzE8L1JlY051bT48RGlzcGxheVRleHQ+WzFdPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjE3MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDEy

MjAzOTg1Ij4xNzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPldhbHNo

LCBULiBKLjwvYXV0aG9yPjxhdXRob3I+QW5haXNzaWUsIEUuIEouPC9hdXRob3I+PGF1dGhvcj5E

ZW5uaW5nLCBELiBXLjwvYXV0aG9yPjxhdXRob3I+SGVyYnJlY2h0LCBSLjwvYXV0aG9yPjxhdXRo

b3I+S29udG95aWFubmlzLCBELiBQLjwvYXV0aG9yPjxhdXRob3I+TWFyciwgSy4gQS48L2F1dGhv

cj48YXV0aG9yPk1vcnJpc29uLCBWLiBBLjwvYXV0aG9yPjxhdXRob3I+U2VnYWwsIEIuIEguPC9h

dXRob3I+PGF1dGhvcj5TdGVpbmJhY2gsIFcuIEouPC9hdXRob3I+PGF1dGhvcj5TdGV2ZW5zLCBE

LiBBLjwvYXV0aG9yPjxhdXRob3I+dmFuIEJ1cmlrLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+V2lu

Z2FyZCwgSi4gUi48L2F1dGhvcj48YXV0aG9yPlBhdHRlcnNvbiwgVC4gRi48L2F1dGhvcj48YXV0

aG9yPkluZmVjdGlvdXMgRGlzZWFzZXMgU29jaWV0eSBvZiwgQW1lcmljYTwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlBlZGlhdHJpYyBPbmNvbG9neSBCcmFu

Y2gsIE5hdGlvbmFsIENhbmNlciBJbnN0aXR1dGUsIEJldGhlc2RhLCBNYXJ5bGFuZCwgVVNBLjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlRyZWF0bWVudCBvZiBhc3BlcmdpbGxvc2lzOiBj

bGluaWNhbCBwcmFjdGljZSBndWlkZWxpbmVzIG9mIHRoZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNv

Y2lldHkgb2YgQW1lcmljYTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluIEluZmVjdCBEaXM8

L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGluZmVjdGlvdXMgZGlzZWFzZXMg

OiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlvbiBvZiB0aGUgSW5mZWN0aW91cyBEaXNlYXNlcyBTb2Np

ZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRs

ZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2xpbi4g

SW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5DbGluIEluZmVjdCBEaXM8L2FiYnItMj48L3Bl

cmlvZGljYWw+PHBhZ2VzPjMyNy02MDwvcGFnZXM+PHZvbHVtZT40Njwvdm9sdW1lPjxudW1iZXI+

MzwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy90aGVyYXBldXRp

YyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kcnVnIHRoZXJhcHkvbWljcm9i

aW9sb2d5Lyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMsIEFsbGVyZ2lj

IEJyb25jaG9wdWxtb25hcnkvZHJ1ZyB0aGVyYXB5L21pY3JvYmlvbG9neS8qdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBEaXNlYXNlcywgRnVu

Z2FsL2RydWcgdGhlcmFweS9taWNyb2Jpb2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MjAwODwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAxPC9kYXRlPjwv

cHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00

ODM4IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xODE3NzIyNTwvYWNjZXNzaW9uLW51

bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1

Ym1lZC8xODE3NzIyNTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTA4Ni81MjUyNTg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3Jk

PjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA [1]. For this update, the IDSA Standards and Practice Guidelines Committee convened a multidisciplinary panel of 17 experts in the management of patients with aspergillosis. The panel consisted of 17 members of the IDSA, and included 16 adult infectious diseases physicians and 1 pediatric infectious diseases physician. All panel members were selected on the basis of their expertise in clinical and/or laboratory mycology with a focus on aspergillosis.Evidence Review - The GRADE Method GRADE is a systematic approach to guideline development that has been described in detail elsewhere PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HdXlhdHQ8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+Nzg5PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsyLCAzXTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj43ODk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0i

MTQ1NDM1OTM4MiI+Nzg5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5H

dXlhdHQsIEcuIEguPC9hdXRob3I+PGF1dGhvcj5PeG1hbiwgQS4gRC48L2F1dGhvcj48YXV0aG9y

PlZpc3QsIEcuIEUuPC9hdXRob3I+PGF1dGhvcj5LdW56LCBSLjwvYXV0aG9yPjxhdXRob3I+RmFs

Y2stWXR0ZXIsIFkuPC9hdXRob3I+PGF1dGhvcj5BbG9uc28tQ29lbGxvLCBQLjwvYXV0aG9yPjxh

dXRob3I+U2NodW5lbWFubiwgSC4gSi48L2F1dGhvcj48YXV0aG9yPkdyYWRlIFdvcmtpbmcgR3Jv

dXA8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRt

ZW50IG9mIENsaW5pY2FsIEVwaWRlbWlvbG9neSBhbmQgQmlvc3RhdGlzdGljcywgTWNNYXN0ZXIg

VW5pdmVyc2l0eSwgSGFtaWx0b24sIE9OLCBDYW5hZGEgTDhOIDNaNS4gZ3V5YXR0QG1jbWFzdGVy

LmNhPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R1JBREU6IGFuIGVtZXJnaW5nIGNvbnNl

bnN1cyBvbiByYXRpbmcgcXVhbGl0eSBvZiBldmlkZW5jZSBhbmQgc3RyZW5ndGggb2YgcmVjb21t

ZW5kYXRpb25zPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJNSjwvc2Vjb25kYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJNSjwvZnVsbC10aXRsZT48YWJici0xPkJN

SjwvYWJici0xPjxhYmJyLTI+Qk1KPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz45MjQtNjwv

cGFnZXM+PHZvbHVtZT4zMzY8L3ZvbHVtZT48bnVtYmVyPjc2NTA8L251bWJlcj48a2V5d29yZHM+

PGtleXdvcmQ+Q29uc2Vuc3VzPC9rZXl3b3JkPjxrZXl3b3JkPkRlY2lzaW9uIE1ha2luZzwva2V5

d29yZD48a2V5d29yZD5FdmlkZW5jZS1CYXNlZCBNZWRpY2luZS9zdGFuZGFyZHM8L2tleXdvcmQ+

PGtleXdvcmQ+UHJhY3RpY2UgR3VpZGVsaW5lcyBhcyBUb3BpYy8qc3RhbmRhcmRzPC9rZXl3b3Jk

PjxrZXl3b3JkPlF1YWxpdHkgSW5kaWNhdG9ycywgSGVhbHRoIENhcmU8L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAwODwveWVhcj48cHViLWRhdGVzPjxkYXRlPkFwciAyNjwvZGF0

ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE3NTYtMTgzMyAoRWxlY3Ryb25pYykmI3hEOzA5

NTktNTM1WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTg0MzY5NDg8L2FjY2Vzc2lv

bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMTg0MzY5NDg8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1D

MjMzNTI2MTwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTEzNi9ibWouMzk0

ODkuNDcwMzQ3LkFEPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENp

dGU+PEF1dGhvcj5HdXlhdHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxSZWNOdW0+MTc4PC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xNzg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSJ0ZWZmc3Y5cHNldnZlaWVkZnozNXR0dGxmOXR6NWVzMmR3dHAi

PjE3ODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi

PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R3V5YXR0LCBHLiBI

LjwvYXV0aG9yPjxhdXRob3I+T3htYW4sIEEuIEQuPC9hdXRob3I+PGF1dGhvcj5TY2h1bmVtYW5u

LCBILiBKLjwvYXV0aG9yPjxhdXRob3I+VHVnd2VsbCwgUC48L2F1dGhvcj48YXV0aG9yPktub3R0

bmVydXMsIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+

RGVwYXJ0bWVudCBvZiBDbGluaWNhbCBFcGlkZW1pb2xvZ3kgYW5kIEJpb3N0YXRpc3RpY3MsIE1j

TWFzdGVyIFVuaXZlcnNpdHksIEhhbWlsdG9uLCBPbnRhcmlvIEw4TiAzWjUsIENhbmFkYS4gZ3V5

YXR0QG1jbWFzdGVyLmNhPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R1JBREUgZ3VpZGVs

aW5lczogYSBuZXcgc2VyaWVzIG9mIGFydGljbGVzIGluIHRoZSBKb3VybmFsIG9mIENsaW5pY2Fs

IEVwaWRlbWlvbG9neTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Kb3VybmFsIG9mIGNsaW5pY2Fs

IGVwaWRlbWlvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SiBDbGluIEVwaWRlbWlv

bDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2Yg

Y2xpbmljYWwgZXBpZGVtaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBDbGluIEVwaWRlbWlv

bDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5h

bCBvZiBjbGluaWNhbCBlcGlkZW1pb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIENsaW4gRXBp

ZGVtaW9sPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MzgwLTI8L3BhZ2VzPjx2b2x1

bWU+NjQ8L3ZvbHVtZT48bnVtYmVyPjQ8L251bWJlcj48ZWRpdGlvbj4yMDEwLzEyLzI4PC9lZGl0

aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5FdmlkZW5jZS1CYXNlZCBNZWRpY2luZS8qc3RhbmRhcmRz

PC9rZXl3b3JkPjxrZXl3b3JkPkd1aWRlbGluZSBBZGhlcmVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+

SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPlBlcmlvZGljYWxzIGFzIFRvcGljL3N0YW5kYXJkczwv

a2V5d29yZD48a2V5d29yZD5QcmFjdGljZSBHdWlkZWxpbmVzIGFzIFRvcGljL3N0YW5kYXJkczwv

a2V5d29yZD48a2V5d29yZD5QdWJsaWNhdGlvbiBCaWFzPC9rZXl3b3JkPjxrZXl3b3JkPlF1YWxp

dHkgQXNzdXJhbmNlLCBIZWFsdGggQ2FyZS8qc3RhbmRhcmRzPC9rZXl3b3JkPjwva2V5d29yZHM+

PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHI8L2RhdGU+PC9wdWIt

ZGF0ZXM+PC9kYXRlcz48aXNibj4xODc4LTU5MjEgKEVsZWN0cm9uaWMpJiN4RDswODk1LTQzNTYg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxMTg1NjkzPC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVk

LzIxMTg1NjkzPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNl

LW51bT4xMC4xMDE2L2ouamNsaW5lcGkuMjAxMC4wOS4wMTE8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HdXlhdHQ8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+Nzg5PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsyLCAzXTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj43ODk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0i

MTQ1NDM1OTM4MiI+Nzg5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5H

dXlhdHQsIEcuIEguPC9hdXRob3I+PGF1dGhvcj5PeG1hbiwgQS4gRC48L2F1dGhvcj48YXV0aG9y

PlZpc3QsIEcuIEUuPC9hdXRob3I+PGF1dGhvcj5LdW56LCBSLjwvYXV0aG9yPjxhdXRob3I+RmFs

Y2stWXR0ZXIsIFkuPC9hdXRob3I+PGF1dGhvcj5BbG9uc28tQ29lbGxvLCBQLjwvYXV0aG9yPjxh

dXRob3I+U2NodW5lbWFubiwgSC4gSi48L2F1dGhvcj48YXV0aG9yPkdyYWRlIFdvcmtpbmcgR3Jv

dXA8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRt

ZW50IG9mIENsaW5pY2FsIEVwaWRlbWlvbG9neSBhbmQgQmlvc3RhdGlzdGljcywgTWNNYXN0ZXIg

VW5pdmVyc2l0eSwgSGFtaWx0b24sIE9OLCBDYW5hZGEgTDhOIDNaNS4gZ3V5YXR0QG1jbWFzdGVy

LmNhPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R1JBREU6IGFuIGVtZXJnaW5nIGNvbnNl

bnN1cyBvbiByYXRpbmcgcXVhbGl0eSBvZiBldmlkZW5jZSBhbmQgc3RyZW5ndGggb2YgcmVjb21t

ZW5kYXRpb25zPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJNSjwvc2Vjb25kYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJNSjwvZnVsbC10aXRsZT48YWJici0xPkJN

SjwvYWJici0xPjxhYmJyLTI+Qk1KPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz45MjQtNjwv

cGFnZXM+PHZvbHVtZT4zMzY8L3ZvbHVtZT48bnVtYmVyPjc2NTA8L251bWJlcj48a2V5d29yZHM+

PGtleXdvcmQ+Q29uc2Vuc3VzPC9rZXl3b3JkPjxrZXl3b3JkPkRlY2lzaW9uIE1ha2luZzwva2V5

d29yZD48a2V5d29yZD5FdmlkZW5jZS1CYXNlZCBNZWRpY2luZS9zdGFuZGFyZHM8L2tleXdvcmQ+

PGtleXdvcmQ+UHJhY3RpY2UgR3VpZGVsaW5lcyBhcyBUb3BpYy8qc3RhbmRhcmRzPC9rZXl3b3Jk

PjxrZXl3b3JkPlF1YWxpdHkgSW5kaWNhdG9ycywgSGVhbHRoIENhcmU8L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAwODwveWVhcj48cHViLWRhdGVzPjxkYXRlPkFwciAyNjwvZGF0

ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE3NTYtMTgzMyAoRWxlY3Ryb25pYykmI3hEOzA5

NTktNTM1WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTg0MzY5NDg8L2FjY2Vzc2lv

bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMTg0MzY5NDg8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1D

MjMzNTI2MTwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTEzNi9ibWouMzk0

ODkuNDcwMzQ3LkFEPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENp

dGU+PEF1dGhvcj5HdXlhdHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxSZWNOdW0+MTc4PC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xNzg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSJ0ZWZmc3Y5cHNldnZlaWVkZnozNXR0dGxmOXR6NWVzMmR3dHAi

PjE3ODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi

PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R3V5YXR0LCBHLiBI

LjwvYXV0aG9yPjxhdXRob3I+T3htYW4sIEEuIEQuPC9hdXRob3I+PGF1dGhvcj5TY2h1bmVtYW5u

LCBILiBKLjwvYXV0aG9yPjxhdXRob3I+VHVnd2VsbCwgUC48L2F1dGhvcj48YXV0aG9yPktub3R0

bmVydXMsIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+

RGVwYXJ0bWVudCBvZiBDbGluaWNhbCBFcGlkZW1pb2xvZ3kgYW5kIEJpb3N0YXRpc3RpY3MsIE1j

TWFzdGVyIFVuaXZlcnNpdHksIEhhbWlsdG9uLCBPbnRhcmlvIEw4TiAzWjUsIENhbmFkYS4gZ3V5

YXR0QG1jbWFzdGVyLmNhPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R1JBREUgZ3VpZGVs

aW5lczogYSBuZXcgc2VyaWVzIG9mIGFydGljbGVzIGluIHRoZSBKb3VybmFsIG9mIENsaW5pY2Fs

IEVwaWRlbWlvbG9neTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Kb3VybmFsIG9mIGNsaW5pY2Fs

IGVwaWRlbWlvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SiBDbGluIEVwaWRlbWlv

bDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2Yg

Y2xpbmljYWwgZXBpZGVtaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBDbGluIEVwaWRlbWlv

bDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5h

bCBvZiBjbGluaWNhbCBlcGlkZW1pb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIENsaW4gRXBp

ZGVtaW9sPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MzgwLTI8L3BhZ2VzPjx2b2x1

bWU+NjQ8L3ZvbHVtZT48bnVtYmVyPjQ8L251bWJlcj48ZWRpdGlvbj4yMDEwLzEyLzI4PC9lZGl0

aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5FdmlkZW5jZS1CYXNlZCBNZWRpY2luZS8qc3RhbmRhcmRz

PC9rZXl3b3JkPjxrZXl3b3JkPkd1aWRlbGluZSBBZGhlcmVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+

SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPlBlcmlvZGljYWxzIGFzIFRvcGljL3N0YW5kYXJkczwv

a2V5d29yZD48a2V5d29yZD5QcmFjdGljZSBHdWlkZWxpbmVzIGFzIFRvcGljL3N0YW5kYXJkczwv

a2V5d29yZD48a2V5d29yZD5QdWJsaWNhdGlvbiBCaWFzPC9rZXl3b3JkPjxrZXl3b3JkPlF1YWxp

dHkgQXNzdXJhbmNlLCBIZWFsdGggQ2FyZS8qc3RhbmRhcmRzPC9rZXl3b3JkPjwva2V5d29yZHM+

PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHI8L2RhdGU+PC9wdWIt

ZGF0ZXM+PC9kYXRlcz48aXNibj4xODc4LTU5MjEgKEVsZWN0cm9uaWMpJiN4RDswODk1LTQzNTYg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxMTg1NjkzPC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVk

LzIxMTg1NjkzPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNl

LW51bT4xMC4xMDE2L2ouamNsaW5lcGkuMjAxMC4wOS4wMTE8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [2, 3]. The IDSA/HIV Medicine Association (HIVMA) adopted GRADE in 2008. In the GRADE system, the guideline panel assigns each recommendation with separate ratings for the underlying quality of evidence supporting the recommendation and for the strength with which the recommendation is made (Figure 1) ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>1113</RecNum><DisplayText>[4]</DisplayText><record><rec-number>1113</rec-number><foreign-keys><key app="EN" db-id="25ws99rfnw2zfmert5rxzapsprpa5wr2efdr" timestamp="1461689151">1113</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>U.S. GRADE Network. Approach and implications to rating the quality of evidence and strength of recommendations using the GRADE methodology. Available at: . Accessed April, 2016</title></titles><dates></dates><urls></urls></record></Cite></EndNote>[4]. Data from randomized controlled trials begin as “high” quality, and data from observational studies begin as “low” quality. However, the panel may judge that specific features of the data warrant decreasing or increasing the quality of evidence rating, and GRADE provides guidance on how such factors should be weighed ADDIN EN.CITE <EndNote><Cite><Author>Guyatt</Author><Year>2011</Year><RecNum>178</RecNum><DisplayText>[3]</DisplayText><record><rec-number>178</rec-number><foreign-keys><key app="EN" db-id="teffsv9psevveiedfz35tttlf9tz5es2dwtp">178</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Guyatt, G. H.</author><author>Oxman, A. D.</author><author>Schunemann, H. J.</author><author>Tugwell, P.</author><author>Knottnerus, A.</author></authors></contributors><auth-address>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 3Z5, Canada. guyatt@mcmaster.ca</auth-address><titles><title>GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology</title><secondary-title>Journal of clinical epidemiology</secondary-title><alt-title>J Clin Epidemiol</alt-title></titles><periodical><full-title>Journal of clinical epidemiology</full-title><abbr-1>J Clin Epidemiol</abbr-1></periodical><alt-periodical><full-title>Journal of clinical epidemiology</full-title><abbr-1>J Clin Epidemiol</abbr-1></alt-periodical><pages>380-2</pages><volume>64</volume><number>4</number><edition>2010/12/28</edition><keywords><keyword>Evidence-Based Medicine/*standards</keyword><keyword>Guideline Adherence</keyword><keyword>Humans</keyword><keyword>Periodicals as Topic/standards</keyword><keyword>Practice Guidelines as Topic/standards</keyword><keyword>Publication Bias</keyword><keyword>Quality Assurance, Health Care/*standards</keyword></keywords><dates><year>2011</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>1878-5921 (Electronic)&#xD;0895-4356 (Linking)</isbn><accession-num>21185693</accession-num><urls><related-urls><url>;[3]. The strength assigned to a recommendation reflects the panel’s confidence that the benefits of following the recommendation are likely to outweigh potential harms. While the quality of evidence is an important factor in choosing recommendation strength, it is not prescriptive. Process Overview Panel members were each assigned to review the recent literature for at least one topic, evaluate the evidence, determine the strength of recommendations and develop written evidence in support of these recommendations. The panel met face-to-face once and conducted a series of conference calls over a 10-month period. The panel reviewed and discussed all recommendations, their strength, and the quality of evidence. Discrepancies were discussed and resolved, and all final recommendations represent a consensus opinion of the entire panel. For the final version of these guidelines, the panel as a group reviewed all individual sections. Panel subgroups generated a list of keywords that were used by librarians at the Health Sciences Library—University of Pittsburg (with grateful acknowledgement to Michele Klein-Fedyshin and Charles B. Wessel) to develop PICO (population, intervention, comparison, outcomes) search strings for use in PubMed and results were returned to each primary author and the chairs for review. Searches were restricted to English language publications and covered the period of January, 2008 (when the last guideline was published) through December, 2014. Abstracts presented at international conferences within the past two years were also reviewed for inclusion. Systematic reviews of relevant topics were identified using PubMed and the Cochrane library. Each primary topic author was responsible for reviewing the literature relevant to their section, and drafting recommendations and evidence summaries for review and discussion by the full panel.Conflicts of InterestsThe expert panel complied with the IDSA policy on conflicts of interest, which requires disclosure of any financial or other interest that may be construed as constituting an actual, potential, or apparent conflict. Panel members were provided IDSA's conflicts of interest disclosure statement and were asked to identify ties to companies developing products that may be affected by promulgation of the guideline. Information was requested regarding employment, consultancies, stock ownership, honoraria, research funding, expert testimony, and membership on company advisory committees. Decisions were made on a case-by-case basis as to whether an individual's role should be limited as a result of a conflict. Potential conflicts of interests are listed in the Acknowledgments section. Review and Approval Process The panel obtained feedback from two external peer reviewers. The guidelines were reviewed and endorsed by the Pediatric Infectious Diseases Society (PIDS). The guideline was reviewed and approved by the IDSA Standards and Practice Guidelines Committee and the IDSA Board of Directors prior to dissemination.Future Guideline RevisionsAt annual intervals, the panel chairs will be asked for their input on the need to update the guideline based on an examination of the current literature. The Standards and Practice Guidelines Committee of the IDSA will consider this input and determine the necessity and timing of an update. If warranted, the entire panel or a subset thereof will be convened to discuss potential changes. EPIDEMIOLOGY AND RISK FACTORS FOR INFECTIONI. How can the most susceptible patients be protected from aspergillosis and which patients are most susceptible? What are sources of exposure to Aspergillus and how can exposure be decreased? Is environmental surveillance useful?Recommendations1.Hospitalized allogeneic HSCT recipients should be placed in a protected environment to reduce mould exposure (Strong Recommendation; Low Quality Evidence). 2.These precautions can be reasonably applied to other highly immunocompromised patients at increased risk for IA, such as patients receiving induction/re-induction regimens for acute leukemia (Strong Recommendation; Low Quality Evidence). 3.In hospitals in which a protected environment is not available, we recommend admission to a private room, no connection to construction sites, and not allowing plants or cut flowers to be brought into the patient’s room (Strong Recommendation; Low Quality Evidence).4.We recommend reasonable precautions to reduce mould exposure among outpatients at high risk for IA, including avoidance of gardening, spreading mulch (compost) or close exposure to construction or renovation (Strong Recommendation; Low Quality Evidence). 5.Leukemia and transplant centers should perform regular surveillance of cases of invasive mould infection. An increase in incidence over baseline or the occurrence of invasive mould infections in patients who are not at high risk for such infections should prompt evaluation for a hospital source (Strong Recommendation; Low Quality Evidence). Evidence summaryAspergillus species and other filamentous fungi are ubiquitous in the environment. The risks of exposure vary both temporally and geographically and are dependent on precipitation patterns, humidity, temperature, and wind conditions PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5hY2thbDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT4yNTMwMjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNV08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MjUzMDI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI1MzAyPC9r

ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl

Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5QYW5hY2thbCwgQS4gQS48L2F1

dGhvcj48YXV0aG9yPkxpLCBILjwvYXV0aG9yPjxhdXRob3I+S29udG95aWFubmlzLCBELiBQLjwv

YXV0aG9yPjxhdXRob3I+TW9yaSwgTS48L2F1dGhvcj48YXV0aG9yPlBlcmVnbywgQy4gQS48L2F1

dGhvcj48YXV0aG9yPkJvZWNraCwgTS48L2F1dGhvcj48YXV0aG9yPk1hcnIsIEsuIEEuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+SGFydmFyZCBTY2hvb2wg

b2YgUHVibGljIEhlYWx0aCwgQm9zdG9uLCBNYXNzYWNodXNldHRzLCBVU0EuPC9hdXRoLWFkZHJl

c3M+PHRpdGxlcz48dGl0bGU+R2VvY2xpbWF0aWMgaW5mbHVlbmNlcyBvbiBpbnZhc2l2ZSBhc3Bl

cmdpbGxvc2lzIGFmdGVyIGhlbWF0b3BvaWV0aWMgc3RlbSBjZWxsIHRyYW5zcGxhbnRhdGlvbjwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48

YWx0LXRpdGxlPkNsaW5pY2FsIGluZmVjdGlvdXMgZGlzZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJs

aWNhdGlvbiBvZiB0aGUgSW5mZWN0aW91cyBEaXNlYXNlcyBTb2NpZXR5IG9mIEFtZXJpY2E8L2Fs

dC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DbGluIEluZmVjdCBEaXM8

L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4xNTg4LTk3PC9wYWdlcz48dm9sdW1lPjUw

PC92b2x1bWU+PG51bWJlcj4xMjwvbnVtYmVyPjxlZGl0aW9uPjIwMTAvMDUvMTE8L2VkaXRpb24+

PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tl

eXdvcmQ+PGtleXdvcmQ+QWlyIE1pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5Bc3Blcmdp

bGxvc2lzLyplcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvaXNvbGF0

aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5FbnZpcm9ubWVudGFsIE1v

bml0b3Jpbmc8L2tleXdvcmQ+PGtleXdvcmQ+RXBpZGVtaW9sb2dpY2FsIE1vbml0b3Jpbmc8L2tl

eXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPipIZW1hdG9wb2lldGljIFN0

ZW0gQ2VsbCBUcmFuc3BsYW50YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3Jk

PjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtl

eXdvcmQ+U2Vhc29uczwva2V5d29yZD48a2V5d29yZD5TcG9yZXMvaXNvbGF0aW9uICZhbXA7IHB1

cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5UZXhhcy9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+V2FzaGluZ3Rvbi9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+V2VhdGhl

cjwva2V5d29yZD48a2V5d29yZD5Zb3VuZyBBZHVsdDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDEwPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuIDE1PC9kYXRlPjwvcHViLWRh

dGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00ODM4IChM

aW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMDQ1MDQxNDwvYWNjZXNzaW9uLW51bT48d29y

ay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJhbCYjeEQ7UmVzZWFyY2gg

U3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIwNDUwNDE0PC91cmw+

PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPjMwMjQwMDk8L2N1c3RvbTI+PGVsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjEwLjEwODYvNjUyNzYxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48

bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5hY2thbDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT4yNTMwMjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNV08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MjUzMDI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI1MzAyPC9r

ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl

Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5QYW5hY2thbCwgQS4gQS48L2F1

dGhvcj48YXV0aG9yPkxpLCBILjwvYXV0aG9yPjxhdXRob3I+S29udG95aWFubmlzLCBELiBQLjwv

YXV0aG9yPjxhdXRob3I+TW9yaSwgTS48L2F1dGhvcj48YXV0aG9yPlBlcmVnbywgQy4gQS48L2F1

dGhvcj48YXV0aG9yPkJvZWNraCwgTS48L2F1dGhvcj48YXV0aG9yPk1hcnIsIEsuIEEuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+SGFydmFyZCBTY2hvb2wg

b2YgUHVibGljIEhlYWx0aCwgQm9zdG9uLCBNYXNzYWNodXNldHRzLCBVU0EuPC9hdXRoLWFkZHJl

c3M+PHRpdGxlcz48dGl0bGU+R2VvY2xpbWF0aWMgaW5mbHVlbmNlcyBvbiBpbnZhc2l2ZSBhc3Bl

cmdpbGxvc2lzIGFmdGVyIGhlbWF0b3BvaWV0aWMgc3RlbSBjZWxsIHRyYW5zcGxhbnRhdGlvbjwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48

YWx0LXRpdGxlPkNsaW5pY2FsIGluZmVjdGlvdXMgZGlzZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJs

aWNhdGlvbiBvZiB0aGUgSW5mZWN0aW91cyBEaXNlYXNlcyBTb2NpZXR5IG9mIEFtZXJpY2E8L2Fs

dC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DbGluIEluZmVjdCBEaXM8

L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4xNTg4LTk3PC9wYWdlcz48dm9sdW1lPjUw

PC92b2x1bWU+PG51bWJlcj4xMjwvbnVtYmVyPjxlZGl0aW9uPjIwMTAvMDUvMTE8L2VkaXRpb24+

PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tl

eXdvcmQ+PGtleXdvcmQ+QWlyIE1pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5Bc3Blcmdp

bGxvc2lzLyplcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvaXNvbGF0

aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5FbnZpcm9ubWVudGFsIE1v

bml0b3Jpbmc8L2tleXdvcmQ+PGtleXdvcmQ+RXBpZGVtaW9sb2dpY2FsIE1vbml0b3Jpbmc8L2tl

eXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPipIZW1hdG9wb2lldGljIFN0

ZW0gQ2VsbCBUcmFuc3BsYW50YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3Jk

PjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtl

eXdvcmQ+U2Vhc29uczwva2V5d29yZD48a2V5d29yZD5TcG9yZXMvaXNvbGF0aW9uICZhbXA7IHB1

cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5UZXhhcy9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+V2FzaGluZ3Rvbi9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+V2VhdGhl

cjwva2V5d29yZD48a2V5d29yZD5Zb3VuZyBBZHVsdDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDEwPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuIDE1PC9kYXRlPjwvcHViLWRh

dGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00ODM4IChM

aW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMDQ1MDQxNDwvYWNjZXNzaW9uLW51bT48d29y

ay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJhbCYjeEQ7UmVzZWFyY2gg

U3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIwNDUwNDE0PC91cmw+

PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPjMwMjQwMDk8L2N1c3RvbTI+PGVsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjEwLjEwODYvNjUyNzYxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48

bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [5]. Inhalation of fungal spores is the most common portal of entry, with sinopulmonary disease the most frequent clinical manifestation. Mould exposure also may occur following the consumption or inhalation of products contaminated with fungal spores PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbGl2ZXI8L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxS

ZWNOdW0+MjU4Njg8L1JlY051bT48RGlzcGxheVRleHQ+WzYsIDddPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjI1ODY4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNTg2ODwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+T2xpdmVyLCBNLiBSLjwvYXV0

aG9yPjxhdXRob3I+VmFuIFZvb3JoaXMsIFcuIEMuPC9hdXRob3I+PGF1dGhvcj5Cb2Vja2gsIE0u

PC9hdXRob3I+PGF1dGhvcj5NYXR0c29uLCBELjwvYXV0aG9yPjxhdXRob3I+Qm93ZGVuLCBSLiBB

LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1l

bnQgb2YgTWVkaWNpbmUsIFVuaXZlcnNpdHkgb2YgV2FzaGluZ3RvbiBNZWRpY2FsIENlbnRlciwg

U2VhdHRsZSwgV2FzaGluZ3RvbiwgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkhl

cGF0aWMgbXVjb3JteWNvc2lzIGluIGEgYm9uZSBtYXJyb3cgdHJhbnNwbGFudCByZWNpcGllbnQg

d2hvIGluZ2VzdGVkIG5hdHVyb3BhdGhpYyBtZWRpY2luZTwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5DbGluIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGlu

ZmVjdGlvdXMgZGlzZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlvbiBvZiB0aGUgSW5mZWN0

aW91cyBEaXNlYXNlcyBTb2NpZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5DbGluIEluZmVjdCBEaXM8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp

Y2FsPjxwYWdlcz41MjEtNDwvcGFnZXM+PHZvbHVtZT4yMjwvdm9sdW1lPjxudW1iZXI+MzwvbnVt

YmVyPjxlZGl0aW9uPjE5OTYvMDMvMDE8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0

PC9rZXl3b3JkPjxrZXl3b3JkPkJhc2UgU2VxdWVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+Qm9uZSBN

YXJyb3cgVHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPipETkEsIEZ1bmdhbDwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TGl2ZXIvKm1pY3JvYmlvbG9n

eS9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TGl2ZXIgRGlzZWFzZXMvKm1pY3JvYmlvbG9n

eS9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5Nb2xl

Y3VsYXIgU2VxdWVuY2UgRGF0YTwva2V5d29yZD48a2V5d29yZD5NdWNvci8qZ2VuZXRpY3MvaXNv

bGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5NdWNvcm15Y29zaXMv

Km1pY3JvYmlvbG9neS9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Kk5hdHVyb3BhdGh5PC9r

ZXl3b3JkPjxrZXl3b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb248L2tleXdvcmQ+PGtleXdv

cmQ+VG9tb2dyYXBoeSBTY2FubmVycywgWC1SYXkgQ29tcHV0ZWQ8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MTk5NjwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1hcjwvZGF0ZT48L3B1

Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwNTgtNDgzOCAoUHJpbnQpJiN4RDsxMDU4LTQ4MzggKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjg4NTI5NzM8L2FjY2Vzc2lvbi1udW0+PHdvcmst

dHlwZT5DYXNlIFJlcG9ydHMmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9z

O3QmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIFUuUy4gR292JmFwb3M7dCwgUC5ILlMuPC93b3JrLXR5

cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9w

dWJtZWQvODg1Mjk3MzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48bGFuZ3VhZ2U+ZW5nPC9s

YW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5UaG9tcHNvbjwvQXV0aG9yPjxZ

ZWFyPjIwMTQ8L1llYXI+PFJlY051bT41MDY8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjUw

NjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjI1d3M5OXJm

bncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDMyNjU5MDk5Ij41MDY8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlRob21wc29uLCBHLiBSLiwg

M3JkPC9hdXRob3I+PGF1dGhvcj5UdXNjYW5vLCBKLiBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5BZHZlcnNlIGhlYWx0aCBlZmZlY3RzIG9mIG1hcmlq

dWFuYSB1c2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TiBFbmdsIEogTWVkPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5UaGUgTmV3IEVuZ2xhbmQgam91cm5hbCBvZiBtZWRpY2luZTwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJu

YWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5OLiBFbmdsLiBKLiBNZWQuPC9hYmJy

LTE+PGFiYnItMj5OIEVuZ2wgSiBNZWQ8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjg3OC05

PC9wYWdlcz48dm9sdW1lPjM3MTwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxrZXl3b3Jkcz48

a2V5d29yZD5DYW5uYWJpbm9pZHMvKnRoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5I

dW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFyaWp1YW5hIFNtb2tpbmcvKmFkdmVyc2UgZWZmZWN0

czwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjxwdWItZGF0ZXM+

PGRhdGU+QXVnIDI4PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzMy00NDA2IChF

bGVjdHJvbmljKSYjeEQ7MDAyOC00NzkzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4y

NTE2MjkwMTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3

dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yNTE2MjkwMTwvdXJsPjwvcmVsYXRlZC11cmxzPjwv

dXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA1Ni9ORUpNYzE0MDc5MjgjU0EyPC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbGl2ZXI8L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxS

ZWNOdW0+MjU4Njg8L1JlY051bT48RGlzcGxheVRleHQ+WzYsIDddPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjI1ODY4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNTg2ODwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+T2xpdmVyLCBNLiBSLjwvYXV0

aG9yPjxhdXRob3I+VmFuIFZvb3JoaXMsIFcuIEMuPC9hdXRob3I+PGF1dGhvcj5Cb2Vja2gsIE0u

PC9hdXRob3I+PGF1dGhvcj5NYXR0c29uLCBELjwvYXV0aG9yPjxhdXRob3I+Qm93ZGVuLCBSLiBB

LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1l

bnQgb2YgTWVkaWNpbmUsIFVuaXZlcnNpdHkgb2YgV2FzaGluZ3RvbiBNZWRpY2FsIENlbnRlciwg

U2VhdHRsZSwgV2FzaGluZ3RvbiwgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkhl

cGF0aWMgbXVjb3JteWNvc2lzIGluIGEgYm9uZSBtYXJyb3cgdHJhbnNwbGFudCByZWNpcGllbnQg

d2hvIGluZ2VzdGVkIG5hdHVyb3BhdGhpYyBtZWRpY2luZTwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5DbGluIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGlu

ZmVjdGlvdXMgZGlzZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlvbiBvZiB0aGUgSW5mZWN0

aW91cyBEaXNlYXNlcyBTb2NpZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5DbGluIEluZmVjdCBEaXM8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp

Y2FsPjxwYWdlcz41MjEtNDwvcGFnZXM+PHZvbHVtZT4yMjwvdm9sdW1lPjxudW1iZXI+MzwvbnVt

YmVyPjxlZGl0aW9uPjE5OTYvMDMvMDE8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0

PC9rZXl3b3JkPjxrZXl3b3JkPkJhc2UgU2VxdWVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+Qm9uZSBN

YXJyb3cgVHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPipETkEsIEZ1bmdhbDwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TGl2ZXIvKm1pY3JvYmlvbG9n

eS9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TGl2ZXIgRGlzZWFzZXMvKm1pY3JvYmlvbG9n

eS9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5Nb2xl

Y3VsYXIgU2VxdWVuY2UgRGF0YTwva2V5d29yZD48a2V5d29yZD5NdWNvci8qZ2VuZXRpY3MvaXNv

bGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5NdWNvcm15Y29zaXMv

Km1pY3JvYmlvbG9neS9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Kk5hdHVyb3BhdGh5PC9r

ZXl3b3JkPjxrZXl3b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb248L2tleXdvcmQ+PGtleXdv

cmQ+VG9tb2dyYXBoeSBTY2FubmVycywgWC1SYXkgQ29tcHV0ZWQ8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MTk5NjwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1hcjwvZGF0ZT48L3B1

Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwNTgtNDgzOCAoUHJpbnQpJiN4RDsxMDU4LTQ4MzggKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjg4NTI5NzM8L2FjY2Vzc2lvbi1udW0+PHdvcmst

dHlwZT5DYXNlIFJlcG9ydHMmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9z

O3QmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIFUuUy4gR292JmFwb3M7dCwgUC5ILlMuPC93b3JrLXR5

cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9w

dWJtZWQvODg1Mjk3MzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48bGFuZ3VhZ2U+ZW5nPC9s

YW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5UaG9tcHNvbjwvQXV0aG9yPjxZ

ZWFyPjIwMTQ8L1llYXI+PFJlY051bT41MDY8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjUw

NjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjI1d3M5OXJm

bncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDMyNjU5MDk5Ij41MDY8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlRob21wc29uLCBHLiBSLiwg

M3JkPC9hdXRob3I+PGF1dGhvcj5UdXNjYW5vLCBKLiBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5BZHZlcnNlIGhlYWx0aCBlZmZlY3RzIG9mIG1hcmlq

dWFuYSB1c2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TiBFbmdsIEogTWVkPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5UaGUgTmV3IEVuZ2xhbmQgam91cm5hbCBvZiBtZWRpY2luZTwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJu

YWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5OLiBFbmdsLiBKLiBNZWQuPC9hYmJy

LTE+PGFiYnItMj5OIEVuZ2wgSiBNZWQ8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjg3OC05

PC9wYWdlcz48dm9sdW1lPjM3MTwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxrZXl3b3Jkcz48

a2V5d29yZD5DYW5uYWJpbm9pZHMvKnRoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5I

dW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFyaWp1YW5hIFNtb2tpbmcvKmFkdmVyc2UgZWZmZWN0

czwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjxwdWItZGF0ZXM+

PGRhdGU+QXVnIDI4PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzMy00NDA2IChF

bGVjdHJvbmljKSYjeEQ7MDAyOC00NzkzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4y

NTE2MjkwMTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3

dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yNTE2MjkwMTwvdXJsPjwvcmVsYXRlZC11cmxzPjwv

dXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA1Ni9ORUpNYzE0MDc5MjgjU0EyPC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [6, 7]. Primary cutaneous aspergillosis has been reported in patients with a breach in the normal protective barrier of the skin – such as in burn victims and near vascular sites in neonates PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXBvdWxpPC9BdXRob3I+PFllYXI+MTk5NjwvWWVhcj48

UmVjTnVtPjI1ODg0PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls4LTExXTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4yNTg4NDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+MjU4ODQ8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlBhcG91bGksIE0uPC9hdXRo

b3I+PGF1dGhvcj5Sb2lsaWRlcywgRS48L2F1dGhvcj48YXV0aG9yPkJpYmFzaGksIEUuPC9hdXRo

b3I+PGF1dGhvcj5BbmRyZW91LCBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgTmVvbmF0b2xvZ3ksIEhpcHBva3JhdGlvbiBIb3Nw

aXRhbCBUaGVzc2Fsb25pa2ksIEdyZWVjZS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Q

cmltYXJ5IGN1dGFuZW91cyBhc3BlcmdpbGxvc2lzIGluIG5lb25hdGVzOiBjYXNlIHJlcG9ydCBh

bmQgcmV2aWV3PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW4gSW5mZWN0IERpczwvc2Vjb25k

YXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwgaW5mZWN0aW91cyBkaXNlYXNlcyA6IGFuIG9m

ZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNvY2lldHkgb2Yg

QW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW4g

SW5mZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjExMDItNDwvcGFnZXM+

PHZvbHVtZT4yMjwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxlZGl0aW9uPjE5OTYvMDYvMDE8

L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFtcGhvdGVyaWNpbiBCL3RoZXJhcGV1dGljIHVz

ZTwva2V5d29yZD48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy90aGVyYXBldXRpYyB1c2U8L2tl

eXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzL2RydWcgdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD4qQXNwZXJnaWxsdXMgZnVtaWdhdHVzL2lzb2xhdGlvbiAmYW1wOyBwdXJp

ZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+RGVybWF0b215Y29zZXMvZGlhZ25vc2lzL2RydWcg

dGhlcmFweS8qbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48

a2V5d29yZD5JbmZhbnQsIE5ld2Jvcm48L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48

L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk2PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuPC9k

YXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA1OC00ODM4IChQcmludCkmI3hEOzEwNTgt

NDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+ODc4MzcyMTwvYWNjZXNzaW9uLW51

bT48d29yay10eXBlPkNhc2UgUmVwb3J0cyYjeEQ7UmV2aWV3PC93b3JrLXR5cGU+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvODc4Mzcy

MTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3Jl

Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj52YW4gQnVyaWs8L0F1dGhvcj48WWVhcj4xOTk4PC9Z

ZWFyPjxSZWNOdW0+NzkwPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj43OTA8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVy

eHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM1OTc4MCI+NzkwPC9rZXk+PC9mb3Jl

aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj

b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj52YW4gQnVyaWssIEouIEEuPC9hdXRob3I+PGF1

dGhvcj5Db2x2ZW4sIFIuPC9hdXRob3I+PGF1dGhvcj5TcGFjaCwgRC4gSC48L2F1dGhvcj48L2F1

dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIE1lZGljaW5l

LCBEaXZpc2lvbiBvZiBBbGxlcmd5IGFuZCBJbmZlY3Rpb3VzIERpc2Vhc2VzLCBTZWF0dGxlLCBX

YXNoaW5ndG9uLCBVU0EuIGp2YW5idXJpQGZoY3JjLm9yZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+

PHRpdGxlPkN1dGFuZW91cyBhc3BlcmdpbGxvc2lzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkog

Q2xpbiBNaWNyb2Jpb2w8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE1pY3JvYmlvbG9neTwvZnVsbC10aXRsZT48YWJi

ci0xPkouIENsaW4uIE1pY3JvYmlvbC48L2FiYnItMT48YWJici0yPkogQ2xpbiBNaWNyb2Jpb2w8

L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjMxMTUtMjE8L3BhZ2VzPjx2b2x1bWU+MzY8L3Zv

bHVtZT48bnVtYmVyPjExPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFJRFMtUmVsYXRlZCBP

cHBvcnR1bmlzdGljIEluZmVjdGlvbnMvZGlhZ25vc2lzL2V0aW9sb2d5L3RoZXJhcHk8L2tleXdv

cmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kaWFnbm9zaXMvKmV0aW9sb2d5L3RoZXJhcHk8L2tl

eXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwv

a2V5d29yZD48a2V5d29yZD5Cb25lIE1hcnJvdyBUcmFuc3BsYW50YXRpb24vYWR2ZXJzZSBlZmZl

Y3RzPC9rZXl3b3JkPjxrZXl3b3JkPkJ1cm5zL2NvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdv

cmQ+RGVybWF0b215Y29zZXMvZGlhZ25vc2lzLypldGlvbG9neS90aGVyYXB5PC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbmZhbnQsIE5ld2Jvcm48L2tleXdvcmQ+

PGtleXdvcmQ+TmVvcGxhc21zL2NvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+T3JnYW4g

VHJhbnNwbGFudGF0aW9uL2FkdmVyc2UgZWZmZWN0czwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4xOTk4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+Tm92PC9kYXRlPjwvcHViLWRhdGVz

PjwvZGF0ZXM+PGlzYm4+MDA5NS0xMTM3IChQcmludCkmI3hEOzAwOTUtMTEzNyAoTGlua2luZyk8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+OTc3NDU0OTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC85Nzc0NTQ5PC91

cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzEwNTI4NTwvY3VzdG9tMj48L3Jl

Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5FdGllbm5lPC9BdXRob3I+PFllYXI+MjAxMTwvWWVh

cj48UmVjTnVtPjc5MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NzkxPC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6

YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9IjE0NTQzNjAzMTAiPjc5MTwva2V5PjwvZm9yZWln

bi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29u

dHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RXRpZW5uZSwgSy4gQS48L2F1dGhvcj48YXV0aG9y

PlN1YnVkaGksIEMuIFAuPC9hdXRob3I+PGF1dGhvcj5DaGFkd2ljaywgUC4gUi48L2F1dGhvcj48

YXV0aG9yPlNldHRsZSwgUC48L2F1dGhvcj48YXV0aG9yPk1vaXNlLCBKLjwvYXV0aG9yPjxhdXRo

b3I+TWFnaWxsLCBTLiBTLjwvYXV0aG9yPjxhdXRob3I+Q2hpbGxlciwgVC48L2F1dGhvcj48YXV0

aG9yPkJhbGFqZWUsIFMuIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+TXljb3RpYyBEaXNlYXNlIEJyYW5jaCwgQ2VudGVycyBmb3IgRGlzZWFzZSBDb250

cm9sIGFuZCBQcmV2ZW50aW9uLCBBdGxhbnRhLCBHQSAzMDMzMywgVVNBLjwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPkludmVzdGlnYXRpb24gb2YgYSBjbHVzdGVyIG9mIGN1dGFuZW91cyBh

c3BlcmdpbGxvc2lzIGluIGEgbmVvbmF0YWwgaW50ZW5zaXZlIGNhcmUgdW5pdDwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5KIEhvc3AgSW5mZWN0PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBIb3NwaXRhbCBJbmZlY3Rpb248L2Z1bGwt

dGl0bGU+PGFiYnItMT5KLiBIb3NwLiBJbmZlY3QuPC9hYmJyLTE+PGFiYnItMj5KIEhvc3AgSW5m

ZWN0PC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz4zNDQtODwvcGFnZXM+PHZvbHVtZT43OTwv

dm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbnRpZnVuZ2FsIEFn

ZW50cy9hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2U8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJn

aWxsb3Npcy8qZXBpZGVtaW9sb2d5L21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5Bc3Bl

cmdpbGx1cyBmdW1pZ2F0dXMvY2xhc3NpZmljYXRpb24vZ2VuZXRpY3MvKmlzb2xhdGlvbiAmYW1w

OyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+KkNsdXN0ZXIgQW5hbHlzaXM8L2tleXdv

cmQ+PGtleXdvcmQ+Q3Jvc3MgSW5mZWN0aW9uLyplcGlkZW1pb2xvZ3kvbWljcm9iaW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPkROQSwgQmFjdGVyaWFsL2NoZW1pc3RyeS9nZW5ldGljczwva2V5d29y

ZD48a2V5d29yZD5EZXJtYXRvbXljb3Nlcy8qZXBpZGVtaW9sb2d5L21pY3JvYmlvbG9neTwva2V5

d29yZD48a2V5d29yZD5FbnZpcm9ubWVudGFsIE1pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29y

ZD5HcmVhdCBCcml0YWluL2VwaWRlbWlvbG9neTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+SW5mYW50LCBOZXdib3JuPC9rZXl3b3JkPjxrZXl3b3JkPkludGVuc2l2

ZSBDYXJlIFVuaXRzLCBOZW9uYXRhbDwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxr

ZXl3b3JkPk1vbGVjdWxhciBUeXBpbmc8L2tleXdvcmQ+PGtleXdvcmQ+U2VxdWVuY2UgQW5hbHlz

aXMsIEROQTwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5

d29yZD5UdWJ1bGluL2dlbmV0aWNzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIw

MTE8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48

aXNibj4xNTMyLTI5MzkgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY3MDEgKExpbmtpbmcpPC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjIxODQwMDg0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIxODQwMDg0PC91cmw+

PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ou

amhpbi4yMDExLjA2LjAxMjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRl

PjxDaXRlPjxBdXRob3I+QnJ5Y2U8L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxSZWNOdW0+Nzky

PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj43OTI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5

cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVm

ZHIiIHRpbWVzdGFtcD0iMTQ1NDM2MDgyNCI+NzkyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10

eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1

dGhvcnM+PGF1dGhvcj5CcnljZSwgRS4gQS48L2F1dGhvcj48YXV0aG9yPldhbGtlciwgTS48L2F1

dGhvcj48YXV0aG9yPlNjaGFyZiwgUy48L2F1dGhvcj48YXV0aG9yPkxpbSwgQS4gVC48L2F1dGhv

cj48YXV0aG9yPldhbHNoLCBBLjwvYXV0aG9yPjxhdXRob3I+U2hhcnAsIE4uPC9hdXRob3I+PGF1

dGhvcj5TbWl0aCwgSi4gQS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt

YWRkcmVzcz5EaXZpc2lvbiBvZiBNZWRpY2FsIE1pY3JvYmlvbG9neSwgVmFuY291dmVyIEhvc3Bp

dGFsLCBCcml0aXNoIENvbHVtYmlhLCBDYW5hZGEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0

bGU+QW4gb3V0YnJlYWsgb2YgY3V0YW5lb3VzIGFzcGVyZ2lsbG9zaXMgaW4gYSB0ZXJ0aWFyeS1j

YXJlIGhvc3BpdGFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkluZmVjdCBDb250cm9sIEhvc3Ag

RXBpZGVtaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0

bGU+SW5mZWN0aW9uIENvbnRyb2wgYW5kIEhvc3BpdGFsIEVwaWRlbWlvbG9neTwvZnVsbC10aXRs

ZT48YWJici0xPkluZmVjdC4gQ29udHJvbCBIb3NwLiBFcGlkZW1pb2wuPC9hYmJyLTE+PGFiYnIt

Mj5JbmZlY3QgQ29udHJvbCBIb3NwIEVwaWRlbWlvbDwvYWJici0yPjxhYmJyLTM+SW5mZWN0aW9u

IENvbnRyb2wgJmFtcDsgSG9zcGl0YWwgRXBpZGVtaW9sb2d5PC9hYmJyLTM+PC9wZXJpb2RpY2Fs

PjxwYWdlcz4xNzAtMjwvcGFnZXM+PHZvbHVtZT4xNzwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVy

PjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lz

LyplcGlkZW1pb2xvZ3kvcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxrZXl3b3Jk

PkJhbmRhZ2VzPC9rZXl3b3JkPjxrZXl3b3JkPkJyaXRpc2ggQ29sdW1iaWEvZXBpZGVtaW9sb2d5

PC9rZXl3b3JkPjxrZXl3b3JkPkRlcm1hdG9teWNvc2VzLyplcGlkZW1pb2xvZ3kvcHJldmVudGlv

biAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxrZXl3b3JkPkRpc2Vhc2UgT3V0YnJlYWtzLypwcmV2

ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+RmFjaWxpdHkgRGVzaWduIGFu

ZCBDb25zdHJ1Y3Rpb248L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWxzL3N0YXRpc3RpY3MgJmFt

cDsgbnVtZXJpY2FsIGRhdGE8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3

b3JkPlBvcHVsYXRpb24gU3VydmVpbGxhbmNlL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+UHJv

ZHVjdCBQYWNrYWdpbmc8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9r

ZXl3b3JkPjxrZXl3b3JkPldvdW5kIEluZmVjdGlvbi8qZXBpZGVtaW9sb2d5L3ByZXZlbnRpb24g

JmFtcDsgY29udHJvbDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk2PC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDg5

OS04MjNYIChQcmludCkmI3hEOzA4OTktODIzWCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+ODcwODM1NjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC84NzA4MzU2PC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXBvdWxpPC9BdXRob3I+PFllYXI+MTk5NjwvWWVhcj48

UmVjTnVtPjI1ODg0PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls4LTExXTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4yNTg4NDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+MjU4ODQ8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlBhcG91bGksIE0uPC9hdXRo

b3I+PGF1dGhvcj5Sb2lsaWRlcywgRS48L2F1dGhvcj48YXV0aG9yPkJpYmFzaGksIEUuPC9hdXRo

b3I+PGF1dGhvcj5BbmRyZW91LCBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgTmVvbmF0b2xvZ3ksIEhpcHBva3JhdGlvbiBIb3Nw

aXRhbCBUaGVzc2Fsb25pa2ksIEdyZWVjZS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Q

cmltYXJ5IGN1dGFuZW91cyBhc3BlcmdpbGxvc2lzIGluIG5lb25hdGVzOiBjYXNlIHJlcG9ydCBh

bmQgcmV2aWV3PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW4gSW5mZWN0IERpczwvc2Vjb25k

YXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwgaW5mZWN0aW91cyBkaXNlYXNlcyA6IGFuIG9m

ZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNvY2lldHkgb2Yg

QW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW4g

SW5mZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjExMDItNDwvcGFnZXM+

PHZvbHVtZT4yMjwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxlZGl0aW9uPjE5OTYvMDYvMDE8

L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFtcGhvdGVyaWNpbiBCL3RoZXJhcGV1dGljIHVz

ZTwva2V5d29yZD48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy90aGVyYXBldXRpYyB1c2U8L2tl

eXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzL2RydWcgdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD4qQXNwZXJnaWxsdXMgZnVtaWdhdHVzL2lzb2xhdGlvbiAmYW1wOyBwdXJp

ZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+RGVybWF0b215Y29zZXMvZGlhZ25vc2lzL2RydWcg

dGhlcmFweS8qbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48

a2V5d29yZD5JbmZhbnQsIE5ld2Jvcm48L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48

L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk2PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuPC9k

YXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA1OC00ODM4IChQcmludCkmI3hEOzEwNTgt

NDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+ODc4MzcyMTwvYWNjZXNzaW9uLW51

bT48d29yay10eXBlPkNhc2UgUmVwb3J0cyYjeEQ7UmV2aWV3PC93b3JrLXR5cGU+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvODc4Mzcy

MTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3Jl

Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj52YW4gQnVyaWs8L0F1dGhvcj48WWVhcj4xOTk4PC9Z

ZWFyPjxSZWNOdW0+NzkwPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj43OTA8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVy

eHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM1OTc4MCI+NzkwPC9rZXk+PC9mb3Jl

aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj

b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj52YW4gQnVyaWssIEouIEEuPC9hdXRob3I+PGF1

dGhvcj5Db2x2ZW4sIFIuPC9hdXRob3I+PGF1dGhvcj5TcGFjaCwgRC4gSC48L2F1dGhvcj48L2F1

dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIE1lZGljaW5l

LCBEaXZpc2lvbiBvZiBBbGxlcmd5IGFuZCBJbmZlY3Rpb3VzIERpc2Vhc2VzLCBTZWF0dGxlLCBX

YXNoaW5ndG9uLCBVU0EuIGp2YW5idXJpQGZoY3JjLm9yZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+

PHRpdGxlPkN1dGFuZW91cyBhc3BlcmdpbGxvc2lzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkog

Q2xpbiBNaWNyb2Jpb2w8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE1pY3JvYmlvbG9neTwvZnVsbC10aXRsZT48YWJi

ci0xPkouIENsaW4uIE1pY3JvYmlvbC48L2FiYnItMT48YWJici0yPkogQ2xpbiBNaWNyb2Jpb2w8

L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjMxMTUtMjE8L3BhZ2VzPjx2b2x1bWU+MzY8L3Zv

bHVtZT48bnVtYmVyPjExPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFJRFMtUmVsYXRlZCBP

cHBvcnR1bmlzdGljIEluZmVjdGlvbnMvZGlhZ25vc2lzL2V0aW9sb2d5L3RoZXJhcHk8L2tleXdv

cmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kaWFnbm9zaXMvKmV0aW9sb2d5L3RoZXJhcHk8L2tl

eXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwv

a2V5d29yZD48a2V5d29yZD5Cb25lIE1hcnJvdyBUcmFuc3BsYW50YXRpb24vYWR2ZXJzZSBlZmZl

Y3RzPC9rZXl3b3JkPjxrZXl3b3JkPkJ1cm5zL2NvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdv

cmQ+RGVybWF0b215Y29zZXMvZGlhZ25vc2lzLypldGlvbG9neS90aGVyYXB5PC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbmZhbnQsIE5ld2Jvcm48L2tleXdvcmQ+

PGtleXdvcmQ+TmVvcGxhc21zL2NvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+T3JnYW4g

VHJhbnNwbGFudGF0aW9uL2FkdmVyc2UgZWZmZWN0czwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4xOTk4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+Tm92PC9kYXRlPjwvcHViLWRhdGVz

PjwvZGF0ZXM+PGlzYm4+MDA5NS0xMTM3IChQcmludCkmI3hEOzAwOTUtMTEzNyAoTGlua2luZyk8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+OTc3NDU0OTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC85Nzc0NTQ5PC91

cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzEwNTI4NTwvY3VzdG9tMj48L3Jl

Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5FdGllbm5lPC9BdXRob3I+PFllYXI+MjAxMTwvWWVh

cj48UmVjTnVtPjc5MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NzkxPC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6

YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9IjE0NTQzNjAzMTAiPjc5MTwva2V5PjwvZm9yZWln

bi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29u

dHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RXRpZW5uZSwgSy4gQS48L2F1dGhvcj48YXV0aG9y

PlN1YnVkaGksIEMuIFAuPC9hdXRob3I+PGF1dGhvcj5DaGFkd2ljaywgUC4gUi48L2F1dGhvcj48

YXV0aG9yPlNldHRsZSwgUC48L2F1dGhvcj48YXV0aG9yPk1vaXNlLCBKLjwvYXV0aG9yPjxhdXRo

b3I+TWFnaWxsLCBTLiBTLjwvYXV0aG9yPjxhdXRob3I+Q2hpbGxlciwgVC48L2F1dGhvcj48YXV0

aG9yPkJhbGFqZWUsIFMuIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+TXljb3RpYyBEaXNlYXNlIEJyYW5jaCwgQ2VudGVycyBmb3IgRGlzZWFzZSBDb250

cm9sIGFuZCBQcmV2ZW50aW9uLCBBdGxhbnRhLCBHQSAzMDMzMywgVVNBLjwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPkludmVzdGlnYXRpb24gb2YgYSBjbHVzdGVyIG9mIGN1dGFuZW91cyBh

c3BlcmdpbGxvc2lzIGluIGEgbmVvbmF0YWwgaW50ZW5zaXZlIGNhcmUgdW5pdDwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5KIEhvc3AgSW5mZWN0PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBIb3NwaXRhbCBJbmZlY3Rpb248L2Z1bGwt

dGl0bGU+PGFiYnItMT5KLiBIb3NwLiBJbmZlY3QuPC9hYmJyLTE+PGFiYnItMj5KIEhvc3AgSW5m

ZWN0PC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz4zNDQtODwvcGFnZXM+PHZvbHVtZT43OTwv

dm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbnRpZnVuZ2FsIEFn

ZW50cy9hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2U8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJn

aWxsb3Npcy8qZXBpZGVtaW9sb2d5L21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5Bc3Bl

cmdpbGx1cyBmdW1pZ2F0dXMvY2xhc3NpZmljYXRpb24vZ2VuZXRpY3MvKmlzb2xhdGlvbiAmYW1w

OyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+KkNsdXN0ZXIgQW5hbHlzaXM8L2tleXdv

cmQ+PGtleXdvcmQ+Q3Jvc3MgSW5mZWN0aW9uLyplcGlkZW1pb2xvZ3kvbWljcm9iaW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPkROQSwgQmFjdGVyaWFsL2NoZW1pc3RyeS9nZW5ldGljczwva2V5d29y

ZD48a2V5d29yZD5EZXJtYXRvbXljb3Nlcy8qZXBpZGVtaW9sb2d5L21pY3JvYmlvbG9neTwva2V5

d29yZD48a2V5d29yZD5FbnZpcm9ubWVudGFsIE1pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29y

ZD5HcmVhdCBCcml0YWluL2VwaWRlbWlvbG9neTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+SW5mYW50LCBOZXdib3JuPC9rZXl3b3JkPjxrZXl3b3JkPkludGVuc2l2

ZSBDYXJlIFVuaXRzLCBOZW9uYXRhbDwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxr

ZXl3b3JkPk1vbGVjdWxhciBUeXBpbmc8L2tleXdvcmQ+PGtleXdvcmQ+U2VxdWVuY2UgQW5hbHlz

aXMsIEROQTwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5

d29yZD5UdWJ1bGluL2dlbmV0aWNzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIw

MTE8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48

aXNibj4xNTMyLTI5MzkgKEVsZWN0cm9uaWMpJiN4RDswMTk1LTY3MDEgKExpbmtpbmcpPC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjIxODQwMDg0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIxODQwMDg0PC91cmw+

PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ou

amhpbi4yMDExLjA2LjAxMjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRl

PjxDaXRlPjxBdXRob3I+QnJ5Y2U8L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxSZWNOdW0+Nzky

PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj43OTI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5

cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVm

ZHIiIHRpbWVzdGFtcD0iMTQ1NDM2MDgyNCI+NzkyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10

eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1

dGhvcnM+PGF1dGhvcj5CcnljZSwgRS4gQS48L2F1dGhvcj48YXV0aG9yPldhbGtlciwgTS48L2F1

dGhvcj48YXV0aG9yPlNjaGFyZiwgUy48L2F1dGhvcj48YXV0aG9yPkxpbSwgQS4gVC48L2F1dGhv

cj48YXV0aG9yPldhbHNoLCBBLjwvYXV0aG9yPjxhdXRob3I+U2hhcnAsIE4uPC9hdXRob3I+PGF1

dGhvcj5TbWl0aCwgSi4gQS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt

YWRkcmVzcz5EaXZpc2lvbiBvZiBNZWRpY2FsIE1pY3JvYmlvbG9neSwgVmFuY291dmVyIEhvc3Bp

dGFsLCBCcml0aXNoIENvbHVtYmlhLCBDYW5hZGEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0

bGU+QW4gb3V0YnJlYWsgb2YgY3V0YW5lb3VzIGFzcGVyZ2lsbG9zaXMgaW4gYSB0ZXJ0aWFyeS1j

YXJlIGhvc3BpdGFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkluZmVjdCBDb250cm9sIEhvc3Ag

RXBpZGVtaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0

bGU+SW5mZWN0aW9uIENvbnRyb2wgYW5kIEhvc3BpdGFsIEVwaWRlbWlvbG9neTwvZnVsbC10aXRs

ZT48YWJici0xPkluZmVjdC4gQ29udHJvbCBIb3NwLiBFcGlkZW1pb2wuPC9hYmJyLTE+PGFiYnIt

Mj5JbmZlY3QgQ29udHJvbCBIb3NwIEVwaWRlbWlvbDwvYWJici0yPjxhYmJyLTM+SW5mZWN0aW9u

IENvbnRyb2wgJmFtcDsgSG9zcGl0YWwgRXBpZGVtaW9sb2d5PC9hYmJyLTM+PC9wZXJpb2RpY2Fs

PjxwYWdlcz4xNzAtMjwvcGFnZXM+PHZvbHVtZT4xNzwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVy

PjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lz

LyplcGlkZW1pb2xvZ3kvcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxrZXl3b3Jk

PkJhbmRhZ2VzPC9rZXl3b3JkPjxrZXl3b3JkPkJyaXRpc2ggQ29sdW1iaWEvZXBpZGVtaW9sb2d5

PC9rZXl3b3JkPjxrZXl3b3JkPkRlcm1hdG9teWNvc2VzLyplcGlkZW1pb2xvZ3kvcHJldmVudGlv

biAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxrZXl3b3JkPkRpc2Vhc2UgT3V0YnJlYWtzLypwcmV2

ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+RmFjaWxpdHkgRGVzaWduIGFu

ZCBDb25zdHJ1Y3Rpb248L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWxzL3N0YXRpc3RpY3MgJmFt

cDsgbnVtZXJpY2FsIGRhdGE8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3

b3JkPlBvcHVsYXRpb24gU3VydmVpbGxhbmNlL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+UHJv

ZHVjdCBQYWNrYWdpbmc8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9r

ZXl3b3JkPjxrZXl3b3JkPldvdW5kIEluZmVjdGlvbi8qZXBpZGVtaW9sb2d5L3ByZXZlbnRpb24g

JmFtcDsgY29udHJvbDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk2PC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDg5

OS04MjNYIChQcmludCkmI3hEOzA4OTktODIzWCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+ODcwODM1NjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC84NzA4MzU2PC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA [8-11]. Contamination of water systems has also been considered a source of nosocomial aspergillosis and other mould infections PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbmFpc3NpZTwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+

PFJlY051bT4yNTI3MzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTItMTddPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjI1MjczPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNTI3

Mzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3

PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QW5haXNzaWUsIEUuIEou

PC9hdXRob3I+PGF1dGhvcj5TdHJhdHRvbiwgUy4gTC48L2F1dGhvcj48YXV0aG9yPkRpZ25hbmks

IE0uIEMuPC9hdXRob3I+PGF1dGhvcj5MZWUsIEMuIEsuPC9hdXRob3I+PGF1dGhvcj5NYWhmb3V6

LCBULiBILjwvYXV0aG9yPjxhdXRob3I+UmV4LCBKLiBILjwvYXV0aG9yPjxhdXRob3I+U3VtbWVy

YmVsbCwgUi4gQy48L2F1dGhvcj48YXV0aG9yPldhbHNoLCBULiBKLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPk15ZWxvbWEgSW5zdGl0dXRlIGZvciBSZXNl

YXJjaCBhbmQgVHJlYXRtZW50LCBBcmthbnNhcyBDYW5jZXIgUmVzZWFyY2ggQ2VudGVyLCBVbml2

ZXJzaXR5IG9mIEFya2Fuc2FzIGZvciBNZWRpY2FsIFNjaWVuY2VzLCBMaXR0bGUgUm9jaywgQVIg

NzIyMDUsIFVTQS4gZWxpYXMxMTRAYW9sLmNvbTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PkNsZWFuaW5nIHBhdGllbnQgc2hvd2VyIGZhY2lsaXRpZXM6IGEgbm92ZWwgYXBwcm9hY2ggdG8g

cmVkdWNpbmcgcGF0aWVudCBleHBvc3VyZSB0byBhZXJvc29saXplZCBBc3BlcmdpbGx1cyBzcGVj

aWVzIGFuZCBvdGhlciBvcHBvcnR1bmlzdGljIG1vbGRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl

PkNsaW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwgaW5m

ZWN0aW91cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZlY3Rp

b3VzIERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkNsaW4gSW5mZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGlj

YWw+PHBhZ2VzPkU4Ni04PC9wYWdlcz48dm9sdW1lPjM1PC92b2x1bWU+PG51bWJlcj44PC9udW1i

ZXI+PGVkaXRpb24+MjAwMi8xMC8wMjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QXNwZXJn

aWxsb3Npcy9taWNyb2Jpb2xvZ3kvKnByZXZlbnRpb24gJmFtcDsgY29udHJvbDwva2V5d29yZD48

a2V5d29yZD4qQXNwZXJnaWxsdXM8L2tleXdvcmQ+PGtleXdvcmQ+RGlzaW5mZWN0aW9uPC9rZXl3

b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5PcHBvcnR1bmlzdGljIEluZmVj

dGlvbnMvbWljcm9iaW9sb2d5LypwcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtl

eXdvcmQ+KlNhbml0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+V2F0ZXIgTWljcm9iaW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPldhdGVyIFN1cHBseTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48

eWVhcj4yMDAyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+T2N0IDE1PC9kYXRlPjwvcHViLWRhdGVz

PjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00ODM4IChMaW5r

aW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMjM1NTM5NzwvYWNjZXNzaW9uLW51bT48dXJscz48

cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xMjM1

NTM5NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTA4Ni8zNDIzMDU8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xh

bmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkFuYWlzc2llPC9BdXRob3I+PFll

YXI+MjAwMjwvWWVhcj48UmVjTnVtPjExMDgzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4x

MTA4MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6

ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+MTEwODM8L2tleT48L2ZvcmVpZ24ta2V5

cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1

dG9ycz48YXV0aG9ycz48YXV0aG9yPkFuYWlzc2llLCBFLiBKLjwvYXV0aG9yPjxhdXRob3I+U3Ry

YXR0b24sIFMuIEwuPC9hdXRob3I+PGF1dGhvcj5EaWduYW5pLCBNLiBDLjwvYXV0aG9yPjxhdXRo

b3I+U3VtbWVyYmVsbCwgUi4gQy48L2F1dGhvcj48YXV0aG9yPlJleCwgSi4gSC48L2F1dGhvcj48

YXV0aG9yPk1vbnNvbiwgVC4gUC48L2F1dGhvcj48YXV0aG9yPlNwZW5jZXIsIFQuPC9hdXRob3I+

PGF1dGhvcj5LYXNhaSwgTS48L2F1dGhvcj48YXV0aG9yPkZyYW5jZXNjb25pLCBBLjwvYXV0aG9y

PjxhdXRob3I+V2Fsc2gsIFQuIEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxh

dXRoLWFkZHJlc3M+TXllbG9tYSBhbmQgVHJhbnNwbGFudGF0aW9uIFJlc2VhcmNoIENlbnRlciwg

QXJrYW5zYXMgQ2FuY2VyIFJlc2VhcmNoIENlbnRlciwgVW5pdmVyc2l0eSBvZiBBcmthbnNhcyBm

b3IgTWVkaWNhbCBTY2llbmNlcywgTGl0dGxlIFJvY2ssIEFSLCA3MjIwNSwgVVNBLiBhbmFpc3Np

ZWVsaWFzakB1YW1zLmVkdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlBhdGhvZ2VuaWMg

QXNwZXJnaWxsdXMgc3BlY2llcyByZWNvdmVyZWQgZnJvbSBhIGhvc3BpdGFsIHdhdGVyIHN5c3Rl

bTogYSAzLXllYXIgcHJvc3BlY3RpdmUgc3R1ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2xp

biBJbmZlY3QgRGlzPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+Q2xpbiBJbmZlY3QgRGlzPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+Nzgw

LTk8L3BhZ2VzPjx2b2x1bWU+MzQ8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48ZWRpdGlvbj4y

MDAyLzAyLzE5PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BaXIgUG9sbHV0aW9uPC9rZXl3

b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvZXBpZGVtaW9sb2d5L21pY3JvYmlvbG9neTwva2V5

d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwv

a2V5d29yZD48a2V5d29yZD5Dcm9zcyBJbmZlY3Rpb24vZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxr

ZXl3b3JkPkhvc3BpdGFsczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv

cmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Q

cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPipXYXRlciBNaWNyb2Jpb2xvZ3k8

L2tleXdvcmQ+PGtleXdvcmQ+KldhdGVyIFBvbGx1dGlvbjwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDAyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyIDE1PC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00ODM4

IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMTg1MDg2MTwvYWNjZXNzaW9uLW51bT48

dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L2VudHJl

ei9xdWVyeS5mY2dpP2NtZD1SZXRyaWV2ZSZhbXA7ZGI9UHViTWVkJmFtcDtkb3B0PUNpdGF0aW9u

JmFtcDtsaXN0X3VpZHM9MTE4NTA4NjE8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0

cm9uaWMtcmVzb3VyY2UtbnVtPkNJRDAxMDY1MSBbcGlpXSYjeEQ7MTAuMTA4Ni8zMzg5NTg8L2Vs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkFuYWlzc2llPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48UmVj

TnVtPjI1MzA3PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yNTMwNzwvcmVjLW51bWJlcj48

Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5

aDkwcHcyZHh6cHRlcCI+MjUzMDc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPkFuYWlzc2llLCBFLiBKLjwvYXV0aG9yPjxhdXRob3I+U3RyYXR0b24sIFMuIEwuPC9hdXRo

b3I+PGF1dGhvcj5EaWduYW5pLCBNLiBDLjwvYXV0aG9yPjxhdXRob3I+TGVlLCBDLiBLLjwvYXV0

aG9yPjxhdXRob3I+U3VtbWVyYmVsbCwgUi4gQy48L2F1dGhvcj48YXV0aG9yPlJleCwgSi4gSC48

L2F1dGhvcj48YXV0aG9yPk1vbnNvbiwgVC4gUC48L2F1dGhvcj48YXV0aG9yPldhbHNoLCBULiBK

LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPk15ZWxvbWEg

SW5zdGl0dXRlIGZvciBSZXNlYXJjaCBhbmQgVHJlYXRtZW50LCBVbml2ZXJzaXR5IG9mIEFya2Fu

c2FzIGZvciBNZWRpY2FsIFNjaWVuY2VzLCBMaXR0bGUgUm9jayA3MjIwNSwgVVNBLiBlbGlhczEx

NEBhb2wuY29tPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UGF0aG9nZW5pYyBtb2xkcyAo

aW5jbHVkaW5nIEFzcGVyZ2lsbHVzIHNwZWNpZXMpIGluIGhvc3BpdGFsIHdhdGVyIGRpc3RyaWJ1

dGlvbiBzeXN0ZW1zOiBhIDMteWVhciBwcm9zcGVjdGl2ZSBzdHVkeSBhbmQgY2xpbmljYWwgaW1w

bGljYXRpb25zIGZvciBwYXRpZW50cyB3aXRoIGhlbWF0b2xvZ2ljIG1hbGlnbmFuY2llczwvdGl0

bGU+PHNlY29uZGFyeS10aXRsZT5CbG9vZDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Qmxv

b2Q8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CbG9vZDwvZnVs

bC10aXRsZT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJsb29kPC9m

dWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjI1NDItNjwvcGFnZXM+PHZvbHVtZT4x

MDE8L3ZvbHVtZT48bnVtYmVyPjc8L251bWJlcj48ZWRpdGlvbj4yMDAyLzEyLzA3PC9lZGl0aW9u

PjxrZXl3b3Jkcz48a2V5d29yZD5BaXIgTWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFz

cGVyZ2lsbHVzL2lzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb24vcGF0aG9nZW5pY2l0eTwva2V5

d29yZD48a2V5d29yZD5Cb25lIE1hcnJvdyBUcmFuc3BsYW50YXRpb24vYWR2ZXJzZSBlZmZlY3Rz

PC9rZXl3b3JkPjxrZXl3b3JkPkNobG9yaW5lL2FuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkZ1

bmdpLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uL3BhdGhvZ2VuaWNpdHk8L2tleXdvcmQ+

PGtleXdvcmQ+SGVtYXRvbG9naWMgTmVvcGxhc21zLypjb21wbGljYXRpb25zPC9rZXl3b3JkPjxr

ZXl3b3JkPkhvc3BpdGFscy8qc3RhbmRhcmRzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5

d29yZD48a2V5d29yZD5JbW11bm9jb21wcm9taXNlZCBIb3N0PC9rZXl3b3JkPjxrZXl3b3JkPk15

Y29zZXMvZXRpb2xvZ3kvKnRyYW5zbWlzc2lvbjwva2V5d29yZD48a2V5d29yZD5PcHBvcnR1bmlz

dGljIEluZmVjdGlvbnMvdHJhbnNtaXNzaW9uPC9rZXl3b3JkPjxrZXl3b3JkPipXYXRlciBNaWNy

b2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+V2F0ZXIgU3VwcGx5L3N0YW5kYXJkczwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXBy

IDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDA2LTQ5NzEgKFByaW50KSYjeEQ7

MDAwNi00OTcxIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMjQ2ODQzNzwvYWNjZXNz

aW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWgu

Z292L3B1Ym1lZC8xMjQ2ODQzNzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25p

Yy1yZXNvdXJjZS1udW0+MTAuMTE4Mi9ibG9vZC0yMDAyLTAyLTA1MzA8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48

QXV0aG9yPkFuYWlzc2llPC9BdXRob3I+PFllYXI+MjAwMTwvWWVhcj48UmVjTnVtPjExMDg1PC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMTA4NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRl

cCI+MTEwODU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRp

Y2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkFuYWlzc2ll

LCBFLiBKLjwvYXV0aG9yPjxhdXRob3I+S3VjaGFyLCBSLiBULjwvYXV0aG9yPjxhdXRob3I+UmV4

LCBKLiBILjwvYXV0aG9yPjxhdXRob3I+RnJhbmNlc2NvbmksIEEuPC9hdXRob3I+PGF1dGhvcj5L

YXNhaSwgTS48L2F1dGhvcj48YXV0aG9yPk11bGxlciwgRi4gTS48L2F1dGhvcj48YXV0aG9yPkxv

emFuby1DaGl1LCBNLjwvYXV0aG9yPjxhdXRob3I+U3VtbWVyYmVsbCwgUi4gQy48L2F1dGhvcj48

YXV0aG9yPkRpZ25hbmksIE0uIEMuPC9hdXRob3I+PGF1dGhvcj5DaGFub2NrLCBTLiBKLjwvYXV0

aG9yPjxhdXRob3I+V2Fsc2gsIFQuIEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+TXllbG9tYSBhbmQgVHJhbnNwbGFudGF0aW9uIFJlc2VhcmNoIENlbnRl

ciwgVW5pdmVyc2l0eSBvZiBBcmthbnNhcyBmb3IgTWVkaWNhbCBTY2llbmNlcywgTGl0dGxlIFJv

Y2ssIEFSIDcyMjA1LCBVU0EuIGFuYWlzc2llZWxpYXNqQGV4Y2hhbmdlLnVhbXMuZWR1PC9hdXRo

LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RnVzYXJpb3NpcyBhc3NvY2lhdGVkIHdpdGggcGF0aG9n

ZW5pYyBmdXNhcml1bSBzcGVjaWVzIGNvbG9uaXphdGlvbiBvZiBhIGhvc3BpdGFsIHdhdGVyIHN5

c3RlbTogYSBuZXcgcGFyYWRpZ20gZm9yIHRoZSBlcGlkZW1pb2xvZ3kgb2Ygb3Bwb3J0dW5pc3Rp

YyBtb2xkIGluZmVjdGlvbnM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2xpbiBJbmZlY3QgRGlz

PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2xpbiBJ

bmZlY3QgRGlzPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MTg3MS04PC9wYWdlcz48

dm9sdW1lPjMzPC92b2x1bWU+PG51bWJlcj4xMTwvbnVtYmVyPjxlZGl0aW9uPjIwMDEvMTEvMDM8

L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFpciBNaWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtl

eXdvcmQ+Q3Jvc3MgSW5mZWN0aW9uLyplcGlkZW1pb2xvZ3kvbWljcm9iaW9sb2d5PC9rZXl3b3Jk

PjxrZXl3b3JkPkROQSwgQmFjdGVyaWFsL2FuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkZ1c2Fy

aXVtL2dlbmV0aWNzLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3JkPjxrZXl3

b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NeWNvc2VzLyplcGlkZW1pb2xvZ3kvbWljcm9i

aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPk9wcG9ydHVuaXN0aWMgSW5mZWN0aW9ucy8qZXBpZGVt

aW9sb2d5L21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD4qV2F0ZXIgTWljcm9iaW9sb2d5

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDE8L3llYXI+PHB1Yi1kYXRlcz48

ZGF0ZT5EZWMgMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzctNjU5MSAoRWxl

Y3Ryb25pYykmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTE2

OTIyOTk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9lbnRyZXovcXVlcnkuZmNnaT9jbWQ9UmV0cmlldmUmYW1wO2RiPVB1

Yk1lZCZhbXA7ZG9wdD1DaXRhdGlvbiZhbXA7bGlzdF91aWRzPTExNjkyMjk5PC91cmw+PC9yZWxh

dGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5DSUQwMTAzNDMgW3BpaV0m

I3hEOzEwLjEwODYvMzI0NTAxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5n

PC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NZXNxdWl0YS1Sb2NoYTwv

QXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051bT4yNTMxNTwvUmVjTnVtPjxyZWNvcmQ+PHJl

Yy1udW1iZXI+MjUzMTU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI1MzE1PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NZXNxdWl0YS1Sb2NoYSwgUy48L2F1dGhv

cj48YXV0aG9yPkdvZG95LU1hcnRpbmV6LCBQLiBDLjwvYXV0aG9yPjxhdXRob3I+R29uY2FsdmVz

LCBTLiBTLjwvYXV0aG9yPjxhdXRob3I+VXJydXRpYSwgTS4gRC48L2F1dGhvcj48YXV0aG9yPkNh

cmxlc3NlLCBGLjwvYXV0aG9yPjxhdXRob3I+U2ViZXIsIEEuPC9hdXRob3I+PGF1dGhvcj5TaWx2

YSwgTS4gQS48L2F1dGhvcj48YXV0aG9yPlBldHJpbGxpLCBBLiBTLjwvYXV0aG9yPjxhdXRob3I+

Q29sb21ibywgQS4gTC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48

dGl0bGU+VGhlIHdhdGVyIHN1cHBseSBzeXN0ZW0gYXMgYSBwb3RlbnRpYWwgc291cmNlIG9mIGZ1

bmdhbCBpbmZlY3Rpb24gaW4gcGFlZGlhdHJpYyBoYWVtYXRvcG9pZXRpYyBzdGVtIGNlbGwgdW5p

dHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qk1DIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPkJNQyBpbmZlY3Rpb3VzIGRpc2Vhc2VzPC9hbHQtdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Qk1DIEluZmVjdCBEaXM8L2Z1bGwtdGl0bGU+PC9wZXJp

b2RpY2FsPjxwYWdlcz4yODk8L3BhZ2VzPjx2b2x1bWU+MTM8L3ZvbHVtZT48ZWRpdGlvbj4yMDEz

LzA2LzI4PC9lZGl0aW9uPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTQ3

MS0yMzM0IChFbGVjdHJvbmljKSYjeEQ7MTQ3MS0yMzM0IChMaW5raW5nKTwvaXNibj48YWNjZXNz

aW9uLW51bT4yMzgwMjg2MjwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJlc2VhcmNoIFN1cHBv

cnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1

cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMzgwMjg2MjwvdXJsPjwvcmVs

YXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj4zNzA4NzY5PC9jdXN0b20yPjxlbGVjdHJvbmljLXJl

c291cmNlLW51bT4xMC4xMTg2LzE0NzEtMjMzNC0xMy0yODk8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9y

PldhcnJpczwvQXV0aG9yPjxZZWFyPjIwMDM8L1llYXI+PFJlY051bT4yNTMyMjwvUmVjTnVtPjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MjUzMjI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI1MzIy

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5XYXJyaXMsIEEuPC9hdXRo

b3I+PGF1dGhvcj5LbGFhc3NlbiwgQy4gSC48L2F1dGhvcj48YXV0aG9yPk1laXMsIEouIEYuPC9h

dXRob3I+PGF1dGhvcj5EZSBSdWl0ZXIsIE0uIFQuPC9hdXRob3I+PGF1dGhvcj5EZSBWYWxrLCBI

LiBBLjwvYXV0aG9yPjxhdXRob3I+QWJyYWhhbXNlbiwgVC4gRy48L2F1dGhvcj48YXV0aG9yPkdh

dXN0YWQsIFAuPC9hdXRob3I+PGF1dGhvcj5WZXJ3ZWlqLCBQLiBFLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgUGVkaWF0cmljcywg

VW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciBTdC4gUmFkYm91ZCwgTmlqbWVnZW4sIFRoZSBOZXRo

ZXJsYW5kcy4gQS5XYXJyaXNAZXJhc211c21jLm5sPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0

bGU+TW9sZWN1bGFyIGVwaWRlbWlvbG9neSBvZiBBc3BlcmdpbGx1cyBmdW1pZ2F0dXMgaXNvbGF0

ZXMgcmVjb3ZlcmVkIGZyb20gd2F0ZXIsIGFpciwgYW5kIHBhdGllbnRzIHNob3dzIHR3byBjbHVz

dGVycyBvZiBnZW5ldGljYWxseSBkaXN0aW5jdCBzdHJhaW5zPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkogQ2xpbiBNaWNyb2Jpb2w8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkpvdXJuYWwg

b2YgY2xpbmljYWwgbWljcm9iaW9sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+SiBDbGluIE1pY3JvYmlvbDwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBh

Z2VzPjQxMDEtNjwvcGFnZXM+PHZvbHVtZT40MTwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxl

ZGl0aW9uPjIwMDMvMDkvMDY8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3

b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+KkFpciBNaWNyb2Jpb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3

b3JkPkFzcGVyZ2lsbHVzIGZ1bWlnYXR1cy9jbGFzc2lmaWNhdGlvbi8qZ2VuZXRpY3MvaXNvbGF0

aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5ETkEgRmluZ2VycHJpbnRp

bmc8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2Vk

PC9rZXl3b3JkPjxrZXl3b3JkPipXYXRlciBNaWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MjAwMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPlNlcDwvZGF0ZT48L3B1

Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwOTUtMTEzNyAoUHJpbnQpJiN4RDswMDk1LTExMzcgKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEyOTU4MjMyPC9hY2Nlc3Npb24tbnVtPjx3b3Jr

LXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1

cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVk

LzEyOTU4MjMyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPjE5Mzc5MjwvY3Vz

dG9tMj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbmFpc3NpZTwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+

PFJlY051bT4yNTI3MzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTItMTddPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjI1MjczPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNTI3

Mzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3

PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QW5haXNzaWUsIEUuIEou

PC9hdXRob3I+PGF1dGhvcj5TdHJhdHRvbiwgUy4gTC48L2F1dGhvcj48YXV0aG9yPkRpZ25hbmks

IE0uIEMuPC9hdXRob3I+PGF1dGhvcj5MZWUsIEMuIEsuPC9hdXRob3I+PGF1dGhvcj5NYWhmb3V6

LCBULiBILjwvYXV0aG9yPjxhdXRob3I+UmV4LCBKLiBILjwvYXV0aG9yPjxhdXRob3I+U3VtbWVy

YmVsbCwgUi4gQy48L2F1dGhvcj48YXV0aG9yPldhbHNoLCBULiBKLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPk15ZWxvbWEgSW5zdGl0dXRlIGZvciBSZXNl

YXJjaCBhbmQgVHJlYXRtZW50LCBBcmthbnNhcyBDYW5jZXIgUmVzZWFyY2ggQ2VudGVyLCBVbml2

ZXJzaXR5IG9mIEFya2Fuc2FzIGZvciBNZWRpY2FsIFNjaWVuY2VzLCBMaXR0bGUgUm9jaywgQVIg

NzIyMDUsIFVTQS4gZWxpYXMxMTRAYW9sLmNvbTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PkNsZWFuaW5nIHBhdGllbnQgc2hvd2VyIGZhY2lsaXRpZXM6IGEgbm92ZWwgYXBwcm9hY2ggdG8g

cmVkdWNpbmcgcGF0aWVudCBleHBvc3VyZSB0byBhZXJvc29saXplZCBBc3BlcmdpbGx1cyBzcGVj

aWVzIGFuZCBvdGhlciBvcHBvcnR1bmlzdGljIG1vbGRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl

PkNsaW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwgaW5m

ZWN0aW91cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZlY3Rp

b3VzIERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkNsaW4gSW5mZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGlj

YWw+PHBhZ2VzPkU4Ni04PC9wYWdlcz48dm9sdW1lPjM1PC92b2x1bWU+PG51bWJlcj44PC9udW1i

ZXI+PGVkaXRpb24+MjAwMi8xMC8wMjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QXNwZXJn

aWxsb3Npcy9taWNyb2Jpb2xvZ3kvKnByZXZlbnRpb24gJmFtcDsgY29udHJvbDwva2V5d29yZD48

a2V5d29yZD4qQXNwZXJnaWxsdXM8L2tleXdvcmQ+PGtleXdvcmQ+RGlzaW5mZWN0aW9uPC9rZXl3

b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5PcHBvcnR1bmlzdGljIEluZmVj

dGlvbnMvbWljcm9iaW9sb2d5LypwcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtl

eXdvcmQ+KlNhbml0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+V2F0ZXIgTWljcm9iaW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPldhdGVyIFN1cHBseTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48

eWVhcj4yMDAyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+T2N0IDE1PC9kYXRlPjwvcHViLWRhdGVz

PjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00ODM4IChMaW5r

aW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMjM1NTM5NzwvYWNjZXNzaW9uLW51bT48dXJscz48

cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xMjM1

NTM5NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTA4Ni8zNDIzMDU8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xh

bmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkFuYWlzc2llPC9BdXRob3I+PFll

YXI+MjAwMjwvWWVhcj48UmVjTnVtPjExMDgzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4x

MTA4MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6

ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+MTEwODM8L2tleT48L2ZvcmVpZ24ta2V5

cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1

dG9ycz48YXV0aG9ycz48YXV0aG9yPkFuYWlzc2llLCBFLiBKLjwvYXV0aG9yPjxhdXRob3I+U3Ry

YXR0b24sIFMuIEwuPC9hdXRob3I+PGF1dGhvcj5EaWduYW5pLCBNLiBDLjwvYXV0aG9yPjxhdXRo

b3I+U3VtbWVyYmVsbCwgUi4gQy48L2F1dGhvcj48YXV0aG9yPlJleCwgSi4gSC48L2F1dGhvcj48

YXV0aG9yPk1vbnNvbiwgVC4gUC48L2F1dGhvcj48YXV0aG9yPlNwZW5jZXIsIFQuPC9hdXRob3I+

PGF1dGhvcj5LYXNhaSwgTS48L2F1dGhvcj48YXV0aG9yPkZyYW5jZXNjb25pLCBBLjwvYXV0aG9y

PjxhdXRob3I+V2Fsc2gsIFQuIEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxh

dXRoLWFkZHJlc3M+TXllbG9tYSBhbmQgVHJhbnNwbGFudGF0aW9uIFJlc2VhcmNoIENlbnRlciwg

QXJrYW5zYXMgQ2FuY2VyIFJlc2VhcmNoIENlbnRlciwgVW5pdmVyc2l0eSBvZiBBcmthbnNhcyBm

b3IgTWVkaWNhbCBTY2llbmNlcywgTGl0dGxlIFJvY2ssIEFSLCA3MjIwNSwgVVNBLiBhbmFpc3Np

ZWVsaWFzakB1YW1zLmVkdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlBhdGhvZ2VuaWMg

QXNwZXJnaWxsdXMgc3BlY2llcyByZWNvdmVyZWQgZnJvbSBhIGhvc3BpdGFsIHdhdGVyIHN5c3Rl

bTogYSAzLXllYXIgcHJvc3BlY3RpdmUgc3R1ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2xp

biBJbmZlY3QgRGlzPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+Q2xpbiBJbmZlY3QgRGlzPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+Nzgw

LTk8L3BhZ2VzPjx2b2x1bWU+MzQ8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48ZWRpdGlvbj4y

MDAyLzAyLzE5PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BaXIgUG9sbHV0aW9uPC9rZXl3

b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvZXBpZGVtaW9sb2d5L21pY3JvYmlvbG9neTwva2V5

d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwv

a2V5d29yZD48a2V5d29yZD5Dcm9zcyBJbmZlY3Rpb24vZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxr

ZXl3b3JkPkhvc3BpdGFsczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv

cmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Q

cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPipXYXRlciBNaWNyb2Jpb2xvZ3k8

L2tleXdvcmQ+PGtleXdvcmQ+KldhdGVyIFBvbGx1dGlvbjwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDAyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyIDE1PC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00ODM4

IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMTg1MDg2MTwvYWNjZXNzaW9uLW51bT48

dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L2VudHJl

ei9xdWVyeS5mY2dpP2NtZD1SZXRyaWV2ZSZhbXA7ZGI9UHViTWVkJmFtcDtkb3B0PUNpdGF0aW9u

JmFtcDtsaXN0X3VpZHM9MTE4NTA4NjE8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0

cm9uaWMtcmVzb3VyY2UtbnVtPkNJRDAxMDY1MSBbcGlpXSYjeEQ7MTAuMTA4Ni8zMzg5NTg8L2Vs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkFuYWlzc2llPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48UmVj

TnVtPjI1MzA3PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yNTMwNzwvcmVjLW51bWJlcj48

Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5

aDkwcHcyZHh6cHRlcCI+MjUzMDc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPkFuYWlzc2llLCBFLiBKLjwvYXV0aG9yPjxhdXRob3I+U3RyYXR0b24sIFMuIEwuPC9hdXRo

b3I+PGF1dGhvcj5EaWduYW5pLCBNLiBDLjwvYXV0aG9yPjxhdXRob3I+TGVlLCBDLiBLLjwvYXV0

aG9yPjxhdXRob3I+U3VtbWVyYmVsbCwgUi4gQy48L2F1dGhvcj48YXV0aG9yPlJleCwgSi4gSC48

L2F1dGhvcj48YXV0aG9yPk1vbnNvbiwgVC4gUC48L2F1dGhvcj48YXV0aG9yPldhbHNoLCBULiBK

LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPk15ZWxvbWEg

SW5zdGl0dXRlIGZvciBSZXNlYXJjaCBhbmQgVHJlYXRtZW50LCBVbml2ZXJzaXR5IG9mIEFya2Fu

c2FzIGZvciBNZWRpY2FsIFNjaWVuY2VzLCBMaXR0bGUgUm9jayA3MjIwNSwgVVNBLiBlbGlhczEx

NEBhb2wuY29tPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UGF0aG9nZW5pYyBtb2xkcyAo

aW5jbHVkaW5nIEFzcGVyZ2lsbHVzIHNwZWNpZXMpIGluIGhvc3BpdGFsIHdhdGVyIGRpc3RyaWJ1

dGlvbiBzeXN0ZW1zOiBhIDMteWVhciBwcm9zcGVjdGl2ZSBzdHVkeSBhbmQgY2xpbmljYWwgaW1w

bGljYXRpb25zIGZvciBwYXRpZW50cyB3aXRoIGhlbWF0b2xvZ2ljIG1hbGlnbmFuY2llczwvdGl0

bGU+PHNlY29uZGFyeS10aXRsZT5CbG9vZDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Qmxv

b2Q8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CbG9vZDwvZnVs

bC10aXRsZT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJsb29kPC9m

dWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjI1NDItNjwvcGFnZXM+PHZvbHVtZT4x

MDE8L3ZvbHVtZT48bnVtYmVyPjc8L251bWJlcj48ZWRpdGlvbj4yMDAyLzEyLzA3PC9lZGl0aW9u

PjxrZXl3b3Jkcz48a2V5d29yZD5BaXIgTWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFz

cGVyZ2lsbHVzL2lzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb24vcGF0aG9nZW5pY2l0eTwva2V5

d29yZD48a2V5d29yZD5Cb25lIE1hcnJvdyBUcmFuc3BsYW50YXRpb24vYWR2ZXJzZSBlZmZlY3Rz

PC9rZXl3b3JkPjxrZXl3b3JkPkNobG9yaW5lL2FuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkZ1

bmdpLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uL3BhdGhvZ2VuaWNpdHk8L2tleXdvcmQ+

PGtleXdvcmQ+SGVtYXRvbG9naWMgTmVvcGxhc21zLypjb21wbGljYXRpb25zPC9rZXl3b3JkPjxr

ZXl3b3JkPkhvc3BpdGFscy8qc3RhbmRhcmRzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5

d29yZD48a2V5d29yZD5JbW11bm9jb21wcm9taXNlZCBIb3N0PC9rZXl3b3JkPjxrZXl3b3JkPk15

Y29zZXMvZXRpb2xvZ3kvKnRyYW5zbWlzc2lvbjwva2V5d29yZD48a2V5d29yZD5PcHBvcnR1bmlz

dGljIEluZmVjdGlvbnMvdHJhbnNtaXNzaW9uPC9rZXl3b3JkPjxrZXl3b3JkPipXYXRlciBNaWNy

b2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+V2F0ZXIgU3VwcGx5L3N0YW5kYXJkczwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXBy

IDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDA2LTQ5NzEgKFByaW50KSYjeEQ7

MDAwNi00OTcxIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMjQ2ODQzNzwvYWNjZXNz

aW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWgu

Z292L3B1Ym1lZC8xMjQ2ODQzNzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25p

Yy1yZXNvdXJjZS1udW0+MTAuMTE4Mi9ibG9vZC0yMDAyLTAyLTA1MzA8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48

QXV0aG9yPkFuYWlzc2llPC9BdXRob3I+PFllYXI+MjAwMTwvWWVhcj48UmVjTnVtPjExMDg1PC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMTA4NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRl

cCI+MTEwODU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRp

Y2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkFuYWlzc2ll

LCBFLiBKLjwvYXV0aG9yPjxhdXRob3I+S3VjaGFyLCBSLiBULjwvYXV0aG9yPjxhdXRob3I+UmV4

LCBKLiBILjwvYXV0aG9yPjxhdXRob3I+RnJhbmNlc2NvbmksIEEuPC9hdXRob3I+PGF1dGhvcj5L

YXNhaSwgTS48L2F1dGhvcj48YXV0aG9yPk11bGxlciwgRi4gTS48L2F1dGhvcj48YXV0aG9yPkxv

emFuby1DaGl1LCBNLjwvYXV0aG9yPjxhdXRob3I+U3VtbWVyYmVsbCwgUi4gQy48L2F1dGhvcj48

YXV0aG9yPkRpZ25hbmksIE0uIEMuPC9hdXRob3I+PGF1dGhvcj5DaGFub2NrLCBTLiBKLjwvYXV0

aG9yPjxhdXRob3I+V2Fsc2gsIFQuIEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+TXllbG9tYSBhbmQgVHJhbnNwbGFudGF0aW9uIFJlc2VhcmNoIENlbnRl

ciwgVW5pdmVyc2l0eSBvZiBBcmthbnNhcyBmb3IgTWVkaWNhbCBTY2llbmNlcywgTGl0dGxlIFJv

Y2ssIEFSIDcyMjA1LCBVU0EuIGFuYWlzc2llZWxpYXNqQGV4Y2hhbmdlLnVhbXMuZWR1PC9hdXRo

LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RnVzYXJpb3NpcyBhc3NvY2lhdGVkIHdpdGggcGF0aG9n

ZW5pYyBmdXNhcml1bSBzcGVjaWVzIGNvbG9uaXphdGlvbiBvZiBhIGhvc3BpdGFsIHdhdGVyIHN5

c3RlbTogYSBuZXcgcGFyYWRpZ20gZm9yIHRoZSBlcGlkZW1pb2xvZ3kgb2Ygb3Bwb3J0dW5pc3Rp

YyBtb2xkIGluZmVjdGlvbnM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2xpbiBJbmZlY3QgRGlz

PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2xpbiBJ

bmZlY3QgRGlzPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MTg3MS04PC9wYWdlcz48

dm9sdW1lPjMzPC92b2x1bWU+PG51bWJlcj4xMTwvbnVtYmVyPjxlZGl0aW9uPjIwMDEvMTEvMDM8

L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFpciBNaWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtl

eXdvcmQ+Q3Jvc3MgSW5mZWN0aW9uLyplcGlkZW1pb2xvZ3kvbWljcm9iaW9sb2d5PC9rZXl3b3Jk

PjxrZXl3b3JkPkROQSwgQmFjdGVyaWFsL2FuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkZ1c2Fy

aXVtL2dlbmV0aWNzLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3JkPjxrZXl3

b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NeWNvc2VzLyplcGlkZW1pb2xvZ3kvbWljcm9i

aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPk9wcG9ydHVuaXN0aWMgSW5mZWN0aW9ucy8qZXBpZGVt

aW9sb2d5L21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD4qV2F0ZXIgTWljcm9iaW9sb2d5

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDE8L3llYXI+PHB1Yi1kYXRlcz48

ZGF0ZT5EZWMgMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzctNjU5MSAoRWxl

Y3Ryb25pYykmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTE2

OTIyOTk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9lbnRyZXovcXVlcnkuZmNnaT9jbWQ9UmV0cmlldmUmYW1wO2RiPVB1

Yk1lZCZhbXA7ZG9wdD1DaXRhdGlvbiZhbXA7bGlzdF91aWRzPTExNjkyMjk5PC91cmw+PC9yZWxh

dGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5DSUQwMTAzNDMgW3BpaV0m

I3hEOzEwLjEwODYvMzI0NTAxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5n

PC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NZXNxdWl0YS1Sb2NoYTwv

QXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051bT4yNTMxNTwvUmVjTnVtPjxyZWNvcmQ+PHJl

Yy1udW1iZXI+MjUzMTU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI1MzE1PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NZXNxdWl0YS1Sb2NoYSwgUy48L2F1dGhv

cj48YXV0aG9yPkdvZG95LU1hcnRpbmV6LCBQLiBDLjwvYXV0aG9yPjxhdXRob3I+R29uY2FsdmVz

LCBTLiBTLjwvYXV0aG9yPjxhdXRob3I+VXJydXRpYSwgTS4gRC48L2F1dGhvcj48YXV0aG9yPkNh

cmxlc3NlLCBGLjwvYXV0aG9yPjxhdXRob3I+U2ViZXIsIEEuPC9hdXRob3I+PGF1dGhvcj5TaWx2

YSwgTS4gQS48L2F1dGhvcj48YXV0aG9yPlBldHJpbGxpLCBBLiBTLjwvYXV0aG9yPjxhdXRob3I+

Q29sb21ibywgQS4gTC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48

dGl0bGU+VGhlIHdhdGVyIHN1cHBseSBzeXN0ZW0gYXMgYSBwb3RlbnRpYWwgc291cmNlIG9mIGZ1

bmdhbCBpbmZlY3Rpb24gaW4gcGFlZGlhdHJpYyBoYWVtYXRvcG9pZXRpYyBzdGVtIGNlbGwgdW5p

dHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qk1DIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPkJNQyBpbmZlY3Rpb3VzIGRpc2Vhc2VzPC9hbHQtdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Qk1DIEluZmVjdCBEaXM8L2Z1bGwtdGl0bGU+PC9wZXJp

b2RpY2FsPjxwYWdlcz4yODk8L3BhZ2VzPjx2b2x1bWU+MTM8L3ZvbHVtZT48ZWRpdGlvbj4yMDEz

LzA2LzI4PC9lZGl0aW9uPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTQ3

MS0yMzM0IChFbGVjdHJvbmljKSYjeEQ7MTQ3MS0yMzM0IChMaW5raW5nKTwvaXNibj48YWNjZXNz

aW9uLW51bT4yMzgwMjg2MjwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJlc2VhcmNoIFN1cHBv

cnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1

cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMzgwMjg2MjwvdXJsPjwvcmVs

YXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj4zNzA4NzY5PC9jdXN0b20yPjxlbGVjdHJvbmljLXJl

c291cmNlLW51bT4xMC4xMTg2LzE0NzEtMjMzNC0xMy0yODk8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9y

PldhcnJpczwvQXV0aG9yPjxZZWFyPjIwMDM8L1llYXI+PFJlY051bT4yNTMyMjwvUmVjTnVtPjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MjUzMjI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI1MzIy

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5XYXJyaXMsIEEuPC9hdXRo

b3I+PGF1dGhvcj5LbGFhc3NlbiwgQy4gSC48L2F1dGhvcj48YXV0aG9yPk1laXMsIEouIEYuPC9h

dXRob3I+PGF1dGhvcj5EZSBSdWl0ZXIsIE0uIFQuPC9hdXRob3I+PGF1dGhvcj5EZSBWYWxrLCBI

LiBBLjwvYXV0aG9yPjxhdXRob3I+QWJyYWhhbXNlbiwgVC4gRy48L2F1dGhvcj48YXV0aG9yPkdh

dXN0YWQsIFAuPC9hdXRob3I+PGF1dGhvcj5WZXJ3ZWlqLCBQLiBFLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgUGVkaWF0cmljcywg

VW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciBTdC4gUmFkYm91ZCwgTmlqbWVnZW4sIFRoZSBOZXRo

ZXJsYW5kcy4gQS5XYXJyaXNAZXJhc211c21jLm5sPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0

bGU+TW9sZWN1bGFyIGVwaWRlbWlvbG9neSBvZiBBc3BlcmdpbGx1cyBmdW1pZ2F0dXMgaXNvbGF0

ZXMgcmVjb3ZlcmVkIGZyb20gd2F0ZXIsIGFpciwgYW5kIHBhdGllbnRzIHNob3dzIHR3byBjbHVz

dGVycyBvZiBnZW5ldGljYWxseSBkaXN0aW5jdCBzdHJhaW5zPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkogQ2xpbiBNaWNyb2Jpb2w8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkpvdXJuYWwg

b2YgY2xpbmljYWwgbWljcm9iaW9sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+SiBDbGluIE1pY3JvYmlvbDwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBh

Z2VzPjQxMDEtNjwvcGFnZXM+PHZvbHVtZT40MTwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxl

ZGl0aW9uPjIwMDMvMDkvMDY8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3

b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+KkFpciBNaWNyb2Jpb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3

b3JkPkFzcGVyZ2lsbHVzIGZ1bWlnYXR1cy9jbGFzc2lmaWNhdGlvbi8qZ2VuZXRpY3MvaXNvbGF0

aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5ETkEgRmluZ2VycHJpbnRp

bmc8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2Vk

PC9rZXl3b3JkPjxrZXl3b3JkPipXYXRlciBNaWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MjAwMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPlNlcDwvZGF0ZT48L3B1

Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwOTUtMTEzNyAoUHJpbnQpJiN4RDswMDk1LTExMzcgKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEyOTU4MjMyPC9hY2Nlc3Npb24tbnVtPjx3b3Jr

LXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1

cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVk

LzEyOTU4MjMyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPjE5Mzc5MjwvY3Vz

dG9tMj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [12-17].Since there are numerous sources of mould in the environment, reasonable efforts should be made to decrease exposure to fungal spores in highly immunocompromised patients. Detailed guidelines have been published regarding hospital room design and ventilation to reduce mould exposure among allogeneic HSCT recipients PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub21ibHluPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48

UmVjTnVtPjc4MjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMThdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjc4MjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIx

NDUyMTIzNDU0Ij43ODI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlRv

bWJseW4sIE0uPC9hdXRob3I+PGF1dGhvcj5DaGlsbGVyLCBULjwvYXV0aG9yPjxhdXRob3I+RWlu

c2VsZSwgSC48L2F1dGhvcj48YXV0aG9yPkdyZXNzLCBSLjwvYXV0aG9yPjxhdXRob3I+U2Vwa293

aXR6LCBLLjwvYXV0aG9yPjxhdXRob3I+U3RvcmVrLCBKLjwvYXV0aG9yPjxhdXRob3I+V2luZ2Fy

ZCwgSi4gUi48L2F1dGhvcj48YXV0aG9yPllvdW5nLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+Qm9l

Y2toLCBNLiBKLjwvYXV0aG9yPjxhdXRob3I+Q2VudGVyIGZvciBJbnRlcm5hdGlvbmFsLCBCbG9v

ZDwvYXV0aG9yPjxhdXRob3I+TWFycm93LCBSZXNlYXJjaDwvYXV0aG9yPjxhdXRob3I+TmF0aW9u

YWwgTWFycm93IERvbm9yLCBwcm9ncmFtPC9hdXRob3I+PGF1dGhvcj5FdXJvcGVhbiwgQmxvb2Q8

L2F1dGhvcj48YXV0aG9yPk1hcnJvd1RyYW5zcGxhbnQsIEdyb3VwPC9hdXRob3I+PGF1dGhvcj5B

bWVyaWNhbiBTb2NpZXR5IG9mLCBCbG9vZDwvYXV0aG9yPjxhdXRob3I+TWFycm93LCBUcmFuc3Bs

YW50YXRpb248L2F1dGhvcj48YXV0aG9yPkNhbmFkaWFuLCBCbG9vZDwvYXV0aG9yPjxhdXRob3I+

TWFycm93IFRyYW5zcGxhbnQsIEdyb3VwPC9hdXRob3I+PGF1dGhvcj5JbmZlY3Rpb3VzIERpc2Vh

c2VzIFNvY2lldHkgb2YsIEFtZXJpY2E8L2F1dGhvcj48YXV0aG9yPlNvY2lldHkgZm9yIEhlYWx0

aGNhcmUgRXBpZGVtaW9sb2d5IG9mLCBBbWVyaWNhPC9hdXRob3I+PGF1dGhvcj5Bc3NvY2lhdGlv

biBvZiBNZWRpY2FsLCBNaWNyb2Jpb2xvZ3k8L2F1dGhvcj48YXV0aG9yPkluZmVjdGlvdXMgRGlz

ZWFzZSwgQ2FuYWRhPC9hdXRob3I+PGF1dGhvcj5DZW50ZXJzIGZvciBEaXNlYXNlLCBDb250cm9s

PC9hdXRob3I+PGF1dGhvcj5QcmV2ZW50aW9uLDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPlVuaXZlcnNpdHkgb2YgTWlubmVzb3RhLCBNaW5uZWFwb2xpcywg

TU4sIFVTQS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5HdWlkZWxpbmVzIGZvciBwcmV2

ZW50aW5nIGluZmVjdGlvdXMgY29tcGxpY2F0aW9ucyBhbW9uZyBoZW1hdG9wb2lldGljIGNlbGwg

dHJhbnNwbGFudGF0aW9uIHJlY2lwaWVudHM6IGEgZ2xvYmFsIHBlcnNwZWN0aXZlPC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkJpb2wgQmxvb2QgTWFycm93IFRyYW5zcGxhbnQ8L3NlY29uZGFyeS10

aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CaW9sb2d5IG9mIEJsb29kIGFu

ZCBNYXJyb3cgVHJhbnNwbGFudGF0aW9uPC9mdWxsLXRpdGxlPjxhYmJyLTE+QmlvbC4gQmxvb2Qg

TWFycm93IFRyYW5zcGxhbnQuPC9hYmJyLTE+PGFiYnItMj5CaW9sIEJsb29kIE1hcnJvdyBUcmFu

c3BsYW50PC9hYmJyLTI+PGFiYnItMz5CaW9sb2d5IG9mIEJsb29kICZhbXA7IE1hcnJvdyBUcmFu

c3BsYW50YXRpb248L2FiYnItMz48L3BlcmlvZGljYWw+PHBhZ2VzPjExNDMtMjM4PC9wYWdlcz48

dm9sdW1lPjE1PC92b2x1bWU+PG51bWJlcj4xMDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD4q

SGVtYXRvcG9pZXRpYyBTdGVtIENlbGwgVHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3Jk

Pkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW5mZWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPklu

ZmVjdGlvbiBDb250cm9sLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlRyYW5zcGxhbnRhdGlv

biwgQXV0b2xvZ291czwva2V5d29yZD48a2V5d29yZD5UcmFuc3BsYW50YXRpb24sIEhvbW9sb2dv

dXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48cHViLWRhdGVz

PjxkYXRlPk9jdDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjMtNjUzNiAoRWxl

Y3Ryb25pYykmI3hEOzEwODMtODc5MSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTk3

NDc2Mjk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTk3NDc2Mjk8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy

bHM+PGN1c3RvbTI+UE1DMzEwMzI5NjwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTAxNi9qLmJibXQuMjAwOS4wNi4wMTk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVj

b3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub21ibHluPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48

UmVjTnVtPjc4MjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMThdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjc4MjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIx

NDUyMTIzNDU0Ij43ODI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlRv

bWJseW4sIE0uPC9hdXRob3I+PGF1dGhvcj5DaGlsbGVyLCBULjwvYXV0aG9yPjxhdXRob3I+RWlu

c2VsZSwgSC48L2F1dGhvcj48YXV0aG9yPkdyZXNzLCBSLjwvYXV0aG9yPjxhdXRob3I+U2Vwa293

aXR6LCBLLjwvYXV0aG9yPjxhdXRob3I+U3RvcmVrLCBKLjwvYXV0aG9yPjxhdXRob3I+V2luZ2Fy

ZCwgSi4gUi48L2F1dGhvcj48YXV0aG9yPllvdW5nLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+Qm9l

Y2toLCBNLiBKLjwvYXV0aG9yPjxhdXRob3I+Q2VudGVyIGZvciBJbnRlcm5hdGlvbmFsLCBCbG9v

ZDwvYXV0aG9yPjxhdXRob3I+TWFycm93LCBSZXNlYXJjaDwvYXV0aG9yPjxhdXRob3I+TmF0aW9u

YWwgTWFycm93IERvbm9yLCBwcm9ncmFtPC9hdXRob3I+PGF1dGhvcj5FdXJvcGVhbiwgQmxvb2Q8

L2F1dGhvcj48YXV0aG9yPk1hcnJvd1RyYW5zcGxhbnQsIEdyb3VwPC9hdXRob3I+PGF1dGhvcj5B

bWVyaWNhbiBTb2NpZXR5IG9mLCBCbG9vZDwvYXV0aG9yPjxhdXRob3I+TWFycm93LCBUcmFuc3Bs

YW50YXRpb248L2F1dGhvcj48YXV0aG9yPkNhbmFkaWFuLCBCbG9vZDwvYXV0aG9yPjxhdXRob3I+

TWFycm93IFRyYW5zcGxhbnQsIEdyb3VwPC9hdXRob3I+PGF1dGhvcj5JbmZlY3Rpb3VzIERpc2Vh

c2VzIFNvY2lldHkgb2YsIEFtZXJpY2E8L2F1dGhvcj48YXV0aG9yPlNvY2lldHkgZm9yIEhlYWx0

aGNhcmUgRXBpZGVtaW9sb2d5IG9mLCBBbWVyaWNhPC9hdXRob3I+PGF1dGhvcj5Bc3NvY2lhdGlv

biBvZiBNZWRpY2FsLCBNaWNyb2Jpb2xvZ3k8L2F1dGhvcj48YXV0aG9yPkluZmVjdGlvdXMgRGlz

ZWFzZSwgQ2FuYWRhPC9hdXRob3I+PGF1dGhvcj5DZW50ZXJzIGZvciBEaXNlYXNlLCBDb250cm9s

PC9hdXRob3I+PGF1dGhvcj5QcmV2ZW50aW9uLDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPlVuaXZlcnNpdHkgb2YgTWlubmVzb3RhLCBNaW5uZWFwb2xpcywg

TU4sIFVTQS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5HdWlkZWxpbmVzIGZvciBwcmV2

ZW50aW5nIGluZmVjdGlvdXMgY29tcGxpY2F0aW9ucyBhbW9uZyBoZW1hdG9wb2lldGljIGNlbGwg

dHJhbnNwbGFudGF0aW9uIHJlY2lwaWVudHM6IGEgZ2xvYmFsIHBlcnNwZWN0aXZlPC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkJpb2wgQmxvb2QgTWFycm93IFRyYW5zcGxhbnQ8L3NlY29uZGFyeS10

aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CaW9sb2d5IG9mIEJsb29kIGFu

ZCBNYXJyb3cgVHJhbnNwbGFudGF0aW9uPC9mdWxsLXRpdGxlPjxhYmJyLTE+QmlvbC4gQmxvb2Qg

TWFycm93IFRyYW5zcGxhbnQuPC9hYmJyLTE+PGFiYnItMj5CaW9sIEJsb29kIE1hcnJvdyBUcmFu

c3BsYW50PC9hYmJyLTI+PGFiYnItMz5CaW9sb2d5IG9mIEJsb29kICZhbXA7IE1hcnJvdyBUcmFu

c3BsYW50YXRpb248L2FiYnItMz48L3BlcmlvZGljYWw+PHBhZ2VzPjExNDMtMjM4PC9wYWdlcz48

dm9sdW1lPjE1PC92b2x1bWU+PG51bWJlcj4xMDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD4q

SGVtYXRvcG9pZXRpYyBTdGVtIENlbGwgVHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3Jk

Pkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW5mZWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPklu

ZmVjdGlvbiBDb250cm9sLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlRyYW5zcGxhbnRhdGlv

biwgQXV0b2xvZ291czwva2V5d29yZD48a2V5d29yZD5UcmFuc3BsYW50YXRpb24sIEhvbW9sb2dv

dXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48cHViLWRhdGVz

PjxkYXRlPk9jdDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjMtNjUzNiAoRWxl

Y3Ryb25pYykmI3hEOzEwODMtODc5MSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTk3

NDc2Mjk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTk3NDc2Mjk8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy

bHM+PGN1c3RvbTI+UE1DMzEwMzI5NjwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTAxNi9qLmJibXQuMjAwOS4wNi4wMTk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVj

b3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA [18]. A “protected environment” is recommended, which includes high efficiency particulate air (HEPA) filtration (and/or laminar airflow), maintenance of positive pressure rooms, and a minimum number of air exchanges per hour. Other at risk groups such as solid organ transplant and burn patients are often also placed in HEPA filtered rooms. Additional guidelines are provided to minimize mould exposure during hospital construction, renovation, and building PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJ0cmlkZ2UtSGluY2tsZXk8L0F1dGhvcj48WWVhcj4y

MDA5PC9ZZWFyPjxSZWNOdW0+NDk2PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxOV08L0Rpc3BsYXlU

ZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDk2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0

aW1lc3RhbXA9IjE0MzA1MDA5ODEiPjQ5Njwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBu

YW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3Jz

PjxhdXRob3I+UGFydHJpZGdlLUhpbmNrbGV5LCBLLjwvYXV0aG9yPjxhdXRob3I+TGlkZGVsbCwg

Ry4gTS48L2F1dGhvcj48YXV0aG9yPkFsbXlyb3VkaXMsIE4uIEcuPC9hdXRob3I+PGF1dGhvcj5T

ZWdhbCwgQi4gSC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5EaXZpc2lvbiBvZiBJbmZlY3Rpb24gQ29udHJvbCwgUm9zd2VsbCBQYXJrIENhbmNlciBJbnN0

aXR1dGUsIEVsbSAmYW1wOyBDYXJsdG9uIFN0cmVldHMsIEJ1ZmZhbG8sIE5ZIDE0MjYzLCBVU0Eu

IGtpbWJlcmx5LmhpbmNrbGV5QHJvc3dlbGxwYXJrLm9yZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+

PHRpdGxlPkluZmVjdGlvbiBjb250cm9sIG1lYXN1cmVzIHRvIHByZXZlbnQgaW52YXNpdmUgbW91

bGQgZGlzZWFzZXMgaW4gaGVtYXRvcG9pZXRpYyBzdGVtIGNlbGwgdHJhbnNwbGFudCByZWNpcGll

bnRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk15Y29wYXRob2xvZ2lhPC9zZWNvbmRhcnktdGl0

bGU+PGFsdC10aXRsZT5NeWNvcGF0aG9sb2dpYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPk15Y29wYXRob2xvZ2lhPC9mdWxsLXRpdGxlPjxhYmJyLTE+TXljb3Bh

dGhvbG9naWE8L2FiYnItMT48YWJici0yPk15Y29wYXRob2xvZ2lhPC9hYmJyLTI+PC9wZXJpb2Rp

Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5NeWNvcGF0aG9sb2dpYTwvZnVsbC10aXRs

ZT48YWJici0xPk15Y29wYXRob2xvZ2lhPC9hYmJyLTE+PGFiYnItMj5NeWNvcGF0aG9sb2dpYTwv

YWJici0yPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjMyOS0zNzwvcGFnZXM+PHZvbHVtZT4xNjg8

L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QW50aWZ1bmdhbCBB

Z2VudHMvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvZXBp

ZGVtaW9sb2d5L2V0aW9sb2d5LypwcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtl

eXdvcmQ+QXNwZXJnaWxsdXMvZHJ1ZyBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW11bml0

eS1BY3F1aXJlZCBJbmZlY3Rpb25zL2V0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkNyb3NzIElu

ZmVjdGlvbi9ldGlvbG9neTwva2V5d29yZD48a2V5d29yZD5FbnZpcm9ubWVudGFsIEV4cG9zdXJl

PC9rZXl3b3JkPjxrZXl3b3JkPkhlbWF0b3BvaWV0aWMgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlv

bi8qYWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5

d29yZD4qSW5mZWN0aW9uIENvbnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+UHJlbWVkaWNhdGlvbjwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA5PC95ZWFyPjxwdWItZGF0ZXM+PGRh

dGU+RGVjPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU3My0wODMyIChFbGVjdHJv

bmljKSYjeEQ7MDMwMS00ODZYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xOTg1OTgy

NTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2Jp

Lm5sbS5uaWguZ292L3B1Ym1lZC8xOTg1OTgyNTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48

ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAwNy9zMTEwNDYtMDA5LTkyNDctejwvZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJ0cmlkZ2UtSGluY2tsZXk8L0F1dGhvcj48WWVhcj4y

MDA5PC9ZZWFyPjxSZWNOdW0+NDk2PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxOV08L0Rpc3BsYXlU

ZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDk2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0

aW1lc3RhbXA9IjE0MzA1MDA5ODEiPjQ5Njwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBu

YW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3Jz

PjxhdXRob3I+UGFydHJpZGdlLUhpbmNrbGV5LCBLLjwvYXV0aG9yPjxhdXRob3I+TGlkZGVsbCwg

Ry4gTS48L2F1dGhvcj48YXV0aG9yPkFsbXlyb3VkaXMsIE4uIEcuPC9hdXRob3I+PGF1dGhvcj5T

ZWdhbCwgQi4gSC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5EaXZpc2lvbiBvZiBJbmZlY3Rpb24gQ29udHJvbCwgUm9zd2VsbCBQYXJrIENhbmNlciBJbnN0

aXR1dGUsIEVsbSAmYW1wOyBDYXJsdG9uIFN0cmVldHMsIEJ1ZmZhbG8sIE5ZIDE0MjYzLCBVU0Eu

IGtpbWJlcmx5LmhpbmNrbGV5QHJvc3dlbGxwYXJrLm9yZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+

PHRpdGxlPkluZmVjdGlvbiBjb250cm9sIG1lYXN1cmVzIHRvIHByZXZlbnQgaW52YXNpdmUgbW91

bGQgZGlzZWFzZXMgaW4gaGVtYXRvcG9pZXRpYyBzdGVtIGNlbGwgdHJhbnNwbGFudCByZWNpcGll

bnRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk15Y29wYXRob2xvZ2lhPC9zZWNvbmRhcnktdGl0

bGU+PGFsdC10aXRsZT5NeWNvcGF0aG9sb2dpYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPk15Y29wYXRob2xvZ2lhPC9mdWxsLXRpdGxlPjxhYmJyLTE+TXljb3Bh

dGhvbG9naWE8L2FiYnItMT48YWJici0yPk15Y29wYXRob2xvZ2lhPC9hYmJyLTI+PC9wZXJpb2Rp

Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5NeWNvcGF0aG9sb2dpYTwvZnVsbC10aXRs

ZT48YWJici0xPk15Y29wYXRob2xvZ2lhPC9hYmJyLTE+PGFiYnItMj5NeWNvcGF0aG9sb2dpYTwv

YWJici0yPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjMyOS0zNzwvcGFnZXM+PHZvbHVtZT4xNjg8

L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QW50aWZ1bmdhbCBB

Z2VudHMvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvZXBp

ZGVtaW9sb2d5L2V0aW9sb2d5LypwcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtl

eXdvcmQ+QXNwZXJnaWxsdXMvZHJ1ZyBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW11bml0

eS1BY3F1aXJlZCBJbmZlY3Rpb25zL2V0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkNyb3NzIElu

ZmVjdGlvbi9ldGlvbG9neTwva2V5d29yZD48a2V5d29yZD5FbnZpcm9ubWVudGFsIEV4cG9zdXJl

PC9rZXl3b3JkPjxrZXl3b3JkPkhlbWF0b3BvaWV0aWMgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlv

bi8qYWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5

d29yZD4qSW5mZWN0aW9uIENvbnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+UHJlbWVkaWNhdGlvbjwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA5PC95ZWFyPjxwdWItZGF0ZXM+PGRh

dGU+RGVjPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU3My0wODMyIChFbGVjdHJv

bmljKSYjeEQ7MDMwMS00ODZYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xOTg1OTgy

NTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2Jp

Lm5sbS5uaWguZ292L3B1Ym1lZC8xOTg1OTgyNTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48

ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAwNy9zMTEwNDYtMDA5LTkyNDctejwvZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA [19]. These guidelines can reasonably be applied to other highly immunocompromised patients, such as those receiving induction/re-induction chemotherapy for acute leukemia. We are in agreement with these guidelines, but note that they are consensus criteria rather than evidence-based. We recognize that highly immunocompromised patients may be admitted to hospitals that lack the engineering standards providing for a “protected environment”. In these settings, reasonable standards include admission to a private room without connection to construction sites, and not allowing plants/cut flowers to be brought into the patient’s room. Patients at risk for mould infections are commonly managed as outpatients where engineering standards are not comparable to the “protected” environment of inpatients. We advise reasonable precautions to reduce mould exposure, including the avoidance of gardening, spreading mulch, or close exposure to construction or renovation. The effectiveness of masks (surgical or N95) to protect against mould infections associated with these exposures is unknown. The majority of cases of invasive mould infections are sporadic, although outbreaks are well-recognized PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UaGlvPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj

TnVtPjc5NDwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMjAtMjNdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjc5NDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIx

NDU0MzYxNTY5Ij43OTQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlRo

aW8sIEMuIEwuPC9hdXRob3I+PGF1dGhvcj5TbWl0aCwgRC48L2F1dGhvcj48YXV0aG9yPk1lcnos

IFcuIEcuPC9hdXRob3I+PGF1dGhvcj5TdHJlaWZlbCwgQS4gSi48L2F1dGhvcj48YXV0aG9yPkJv

dmEsIEcuPC9hdXRob3I+PGF1dGhvcj5HYXksIEwuPC9hdXRob3I+PGF1dGhvcj5NaWxsZXIsIEMu

IEIuPC9hdXRob3I+PGF1dGhvcj5QZXJsLCBULiBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlzaW9uIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIEpv

aG5zIEhvcGtpbnMgU2Nob29sIG9mIE1lZGljaW5lLCBCYWx0aW1vcmUsIE1hcnlsYW5kLCBVU0Eu

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UmVmaW5lbWVudHMgb2YgZW52aXJvbm1lbnRh

bCBhc3Nlc3NtZW50IGR1cmluZyBhbiBvdXRicmVhayBpbnZlc3RpZ2F0aW9uIG9mIGludmFzaXZl

IGFzcGVyZ2lsbG9zaXMgaW4gYSBsZXVrZW1pYSBhbmQgYm9uZSBtYXJyb3cgdHJhbnNwbGFudCB1

bml0PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkluZmVjdCBDb250cm9sIEhvc3AgRXBpZGVtaW9s

PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SW5mZWN0

aW9uIENvbnRyb2wgYW5kIEhvc3BpdGFsIEVwaWRlbWlvbG9neTwvZnVsbC10aXRsZT48YWJici0x

PkluZmVjdC4gQ29udHJvbCBIb3NwLiBFcGlkZW1pb2wuPC9hYmJyLTE+PGFiYnItMj5JbmZlY3Qg

Q29udHJvbCBIb3NwIEVwaWRlbWlvbDwvYWJici0yPjxhYmJyLTM+SW5mZWN0aW9uIENvbnRyb2wg

JmFtcDsgSG9zcGl0YWwgRXBpZGVtaW9sb2d5PC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxwYWdlcz4x

OC0yMzwvcGFnZXM+PHZvbHVtZT4yMTwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxrZXl3b3Jk

cz48a2V5d29yZD5BbmFseXNpcyBvZiBWYXJpYW5jZTwva2V5d29yZD48a2V5d29yZD5Bc3Blcmdp

bGxvc2lzL2VwaWRlbWlvbG9neS8qcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxr

ZXl3b3JkPkJhbHRpbW9yZS9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Qm9uZSBNYXJy

b3cgVHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkNhc2UtQ29udHJvbCBTdHVkaWVz

PC9rZXl3b3JkPjxrZXl3b3JkPkRpc2Vhc2UgT3V0YnJlYWtzLypwcmV2ZW50aW9uICZhbXA7IGNv

bnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+RW52aXJvbm1lbnRhbCBNb25pdG9yaW5nLyptZXRob2Rz

PC9rZXl3b3JkPjxrZXl3b3JkPkVwaWRlbWlvbG9naWNhbCBNb25pdG9yaW5nPC9rZXl3b3JkPjxr

ZXl3b3JkPkZhY2lsaXR5IERlc2lnbiBhbmQgQ29uc3RydWN0aW9uPC9rZXl3b3JkPjxrZXl3b3Jk

PkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5mZWN0

aW9uIENvbnRyb2wvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+TGV1a2VtaWEvKm1pY3JvYmlv

bG9neS90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkxvZ2lzdGljIE1vZGVsczwva2V5d29yZD48

a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3

b3JkPk9kZHMgUmF0aW88L2tleXdvcmQ+PGtleXdvcmQ+UmlzayBGYWN0b3JzPC9rZXl3b3JkPjxr

ZXl3b3JkPlZlbnRpbGF0aW9uPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDA8

L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KYW48L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNi

bj4wODk5LTgyM1ggKFByaW50KSYjeEQ7MDg5OS04MjNYIChMaW5raW5nKTwvaXNibj48YWNjZXNz

aW9uLW51bT4xMDY1NjM0OTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xMDY1NjM0OTwvdXJsPjwvcmVsYXRl

ZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA4Ni81MDE2OTE8L2Vs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhhaG48

L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxSZWNOdW0+Nzk1PC9SZWNOdW0+PHJlY29yZD48cmVj

LW51bWJlcj43OTU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlk

PSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM2

MjA0OCI+Nzk1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IYWhuLCBU

LjwvYXV0aG9yPjxhdXRob3I+Q3VtbWluZ3MsIEsuIE0uPC9hdXRob3I+PGF1dGhvcj5NaWNoYWxl

aywgQS4gTS48L2F1dGhvcj48YXV0aG9yPkxpcG1hbiwgQi4gSi48L2F1dGhvcj48YXV0aG9yPlNl

Z2FsLCBCLiBILjwvYXV0aG9yPjxhdXRob3I+TWNDYXJ0aHksIFAuIEwuLCBKci48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIE1lZGlj

aW5lLCBSb3N3ZWxsIFBhcmsgQ2FuY2VyIEluc3RpdHV0ZSwgQnVmZmFsbywgTmV3IFlvcmsgMTQy

NjMsIFVTQS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5FZmZpY2FjeSBvZiBoaWdoLWVm

ZmljaWVuY3kgcGFydGljdWxhdGUgYWlyIGZpbHRyYXRpb24gaW4gcHJldmVudGluZyBhc3Blcmdp

bGxvc2lzIGluIGltbXVub2NvbXByb21pc2VkIHBhdGllbnRzIHdpdGggaGVtYXRvbG9naWMgbWFs

aWduYW5jaWVzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkluZmVjdCBDb250cm9sIEhvc3AgRXBp

ZGVtaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

SW5mZWN0aW9uIENvbnRyb2wgYW5kIEhvc3BpdGFsIEVwaWRlbWlvbG9neTwvZnVsbC10aXRsZT48

YWJici0xPkluZmVjdC4gQ29udHJvbCBIb3NwLiBFcGlkZW1pb2wuPC9hYmJyLTE+PGFiYnItMj5J

bmZlY3QgQ29udHJvbCBIb3NwIEVwaWRlbWlvbDwvYWJici0yPjxhYmJyLTM+SW5mZWN0aW9uIENv

bnRyb2wgJmFtcDsgSG9zcGl0YWwgRXBpZGVtaW9sb2d5PC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxw

YWdlcz41MjUtMzE8L3BhZ2VzPjx2b2x1bWU+MjM8L3ZvbHVtZT48bnVtYmVyPjk8L251bWJlcj48

a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5

d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9r

ZXl3b3JkPjxrZXl3b3JkPkFpciBDb25kaXRpb25pbmcvKm1ldGhvZHMvc3RhbmRhcmRzPC9rZXl3

b3JkPjxrZXl3b3JkPipBaXIgTWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2ls

bG9zaXMvZXRpb2xvZ3kvKnByZXZlbnRpb24gJmFtcDsgY29udHJvbC90cmFuc21pc3Npb248L2tl

eXdvcmQ+PGtleXdvcmQ+KkFzcGVyZ2lsbHVzIGZsYXZ1czwva2V5d29yZD48a2V5d29yZD5DYW5j

ZXIgQ2FyZSBGYWNpbGl0aWVzPC9rZXl3b3JkPjxrZXl3b3JkPkNyb3NzIEluZmVjdGlvbi9ldGlv

bG9neS8qcHJldmVudGlvbiAmYW1wOyBjb250cm9sL3RyYW5zbWlzc2lvbjwva2V5d29yZD48a2V5

d29yZD5EaXNlYXNlIE91dGJyZWFrcy9wcmV2ZW50aW9uICZhbXA7IGNvbnRyb2wvc3RhdGlzdGlj

cyAmYW1wOyBudW1lcmljYWwgZGF0YTwva2V5d29yZD48a2V5d29yZD5FbnZpcm9ubWVudGFsIE1v

bml0b3Jpbmc8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZpbHRy

YXRpb24vKm1ldGhvZHMvc3RhbmRhcmRzPC9rZXl3b3JkPjxrZXl3b3JkPkhlbWF0b2xvZ2ljIE5l

b3BsYXNtcy8qY29tcGxpY2F0aW9uczwva2V5d29yZD48a2V5d29yZD5Ib3NwaXRhbCBEZXNpZ24g

YW5kIENvbnN0cnVjdGlvbjwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv

cmQ+KkltbXVub2NvbXByb21pc2VkIEhvc3Q8L2tleXdvcmQ+PGtleXdvcmQ+SW5mZWN0aW9uIENv

bnRyb2wvKm1ldGhvZHMvc3RhbmRhcmRzPC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcgRGlzZWFzZXMs

IEZ1bmdhbC9ldGlvbG9neS8qcHJldmVudGlvbiAmYW1wOyBjb250cm9sL3RyYW5zbWlzc2lvbjwv

a2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPk5ldyBZb3JrPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1

ZGllczwva2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48

ZGF0ZXM+PHllYXI+MjAwMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPlNlcDwvZGF0ZT48L3B1Yi1k

YXRlcz48L2RhdGVzPjxpc2JuPjA4OTktODIzWCAoUHJpbnQpJiN4RDswODk5LTgyM1ggKExpbmtp

bmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEyMjY5NDUxPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxy

ZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzEyMjY5

NDUxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4x

MC4xMDg2LzUwMjEwMTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxD

aXRlPjxBdXRob3I+UmF2aXY8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxSZWNOdW0+Nzk2PC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj43OTY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIi

IHRpbWVzdGFtcD0iMTQ1NDM2MjA5MiI+Nzk2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBl

IG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhv

cnM+PGF1dGhvcj5SYXZpdiwgWS48L2F1dGhvcj48YXV0aG9yPktyYW1lciwgTS4gUi48L2F1dGhv

cj48YXV0aG9yPkFtaXRhbCwgQS48L2F1dGhvcj48YXV0aG9yPlJ1Ymlub3ZpdGNoLCBCLjwvYXV0

aG9yPjxhdXRob3I+QmlzaGFyYSwgSi48L2F1dGhvcj48YXV0aG9yPlNoaXRyaXQsIEQuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+UHVsbW9uYXJ5IEluc3Rp

dHV0ZSwgUmFiaW4gTWVkaWNhbCBDZW50ZXIsIFNhY2tsZXIgU2Nob29sIG9mIE1lZGljaW5lLCBU

ZWwtQXZpdiwgSXNyYWVsLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk91dGJyZWFrIG9m

IGFzcGVyZ2lsbG9zaXMgaW5mZWN0aW9ucyBhbW9uZyBsdW5nIHRyYW5zcGxhbnQgcmVjaXBpZW50

czwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5UcmFuc3BsIEludDwvc2Vjb25kYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlRyYW5zcGxhbnQgSW50ZXJuYXRpb25hbDwv

ZnVsbC10aXRsZT48YWJici0xPlRyYW5zcGwuIEludC48L2FiYnItMT48YWJici0yPlRyYW5zcGwg

SW50PC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz4xMzUtNDA8L3BhZ2VzPjx2b2x1bWU+MjA8

L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdv

cmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2NvbXBsaWNh

dGlvbnMvZXBpZGVtaW9sb2d5LypldGlvbG9neTwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIE91

dGJyZWFrczwva2V5d29yZD48a2V5d29yZD5FbnZpcm9ubWVudGFsIEV4cG9zdXJlLyphZHZlcnNl

IGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+RmFjaWxpdHkgRGVzaWduIGFuZCBDb25zdHJ1Y3Rp

b248L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5

d29yZD48a2V5d29yZD5MdW5nIERpc2Vhc2VzLCBGdW5nYWwvY29tcGxpY2F0aW9ucy9lcGlkZW1p

b2xvZ3kvKmV0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcgVHJhbnNwbGFudGF0aW9uLyph

ZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5N

aWRkbGUgQWdlZDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA3PC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+RmViPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDkzNC0w

ODc0IChQcmludCkmI3hEOzA5MzQtMDg3NCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+

MTcyMzkwMjE8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93

d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTcyMzkwMjE8L3VybD48L3JlbGF0ZWQtdXJscz48

L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMTEvai4xNDMyLTIyNzcuMjAwNi4w

MDQxMS54PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1

dGhvcj5QZWxhZXo8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNOdW0+MjUzNTc8L1JlY051

bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI1MzU3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4y

NTM1Nzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi

PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UGVsYWV6LCBULjwv

YXV0aG9yPjxhdXRob3I+TXVub3osIFAuPC9hdXRob3I+PGF1dGhvcj5HdWluZWEsIEouPC9hdXRo

b3I+PGF1dGhvcj5WYWxlcmlvLCBNLjwvYXV0aG9yPjxhdXRob3I+R2lhbm5lbGxhLCBNLjwvYXV0

aG9yPjxhdXRob3I+S2xhYXNzZW4sIEMuIEguPC9hdXRob3I+PGF1dGhvcj5Cb3V6YSwgRS48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9m

IENsaW5pY2FsIE1pY3JvYmlvbG9neSBhbmQgSW5mZWN0aW91cyBEaXNlYXNlcywgSG9zcGl0YWwg

R2VuZXJhbCBVbml2ZXJzaXRhcmlvIEdyZWdvcmlvIE1hcmFub24sIE1hZHJpZCwgU3BhaW4uPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+T3V0YnJlYWsgb2YgaW52YXNpdmUgYXNwZXJnaWxs

b3NpcyBhZnRlciBtYWpvciBoZWFydCBzdXJnZXJ5IGNhdXNlZCBieSBzcG9yZXMgaW4gdGhlIGFp

ciBvZiB0aGUgaW50ZW5zaXZlIGNhcmUgdW5pdDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGlu

IEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGluZmVjdGlv

dXMgZGlzZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlvbiBvZiB0aGUgSW5mZWN0aW91cyBE

aXNlYXNlcyBTb2NpZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5DbGluIEluZmVjdCBEaXM8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxw

YWdlcz5lMjQtMzE8L3BhZ2VzPjx2b2x1bWU+NTQ8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48

ZWRpdGlvbj4yMDEyLzAxLzE3PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkLCA4MCBh

bmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD4qQWlyIE1pY3JvYmlvbG9neTwva2V5d29yZD48a2V5

d29yZD5BbnRpZnVuZ2FsIEFnZW50cy90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+

QXNwZXJnaWxsb3Npcy9kcnVnIHRoZXJhcHkvZXBpZGVtaW9sb2d5LypldGlvbG9neTwva2V5d29y

ZD48a2V5d29yZD5Bc3BlcmdpbGx1cy8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5

d29yZD48a2V5d29yZD5DYXJkaWFjIFN1cmdpY2FsIFByb2NlZHVyZXMvKmFkdmVyc2UgZWZmZWN0

czwva2V5d29yZD48a2V5d29yZD4qQ29yb25hcnkgQ2FyZSBVbml0czwva2V5d29yZD48a2V5d29y

ZD4qRGlzZWFzZSBPdXRicmVha3M8L2tleXdvcmQ+PGtleXdvcmQ+RWNoaW5vY2FuZGlucy90aGVy

YXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1

bWFuczwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwv

a2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5QeXJpbWlkaW5l

cy90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+U3BvcmVzLCBGdW5nYWwvaXNvbGF0

aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5Ucmlhem9sZXMvdGhlcmFw

ZXV0aWMgdXNlPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTI8L3llYXI+PHB1

Yi1kYXRlcz48ZGF0ZT5GZWIgMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1Mzct

NjU5MSAoRWxlY3Ryb25pYykmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MjIyNDczMDc8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0

LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjIyNDczMDc8L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvY2lkL2Npcjc3

MTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNv

cmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UaGlvPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj

TnVtPjc5NDwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMjAtMjNdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjc5NDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIx

NDU0MzYxNTY5Ij43OTQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlRo

aW8sIEMuIEwuPC9hdXRob3I+PGF1dGhvcj5TbWl0aCwgRC48L2F1dGhvcj48YXV0aG9yPk1lcnos

IFcuIEcuPC9hdXRob3I+PGF1dGhvcj5TdHJlaWZlbCwgQS4gSi48L2F1dGhvcj48YXV0aG9yPkJv

dmEsIEcuPC9hdXRob3I+PGF1dGhvcj5HYXksIEwuPC9hdXRob3I+PGF1dGhvcj5NaWxsZXIsIEMu

IEIuPC9hdXRob3I+PGF1dGhvcj5QZXJsLCBULiBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlzaW9uIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIEpv

aG5zIEhvcGtpbnMgU2Nob29sIG9mIE1lZGljaW5lLCBCYWx0aW1vcmUsIE1hcnlsYW5kLCBVU0Eu

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UmVmaW5lbWVudHMgb2YgZW52aXJvbm1lbnRh

bCBhc3Nlc3NtZW50IGR1cmluZyBhbiBvdXRicmVhayBpbnZlc3RpZ2F0aW9uIG9mIGludmFzaXZl

IGFzcGVyZ2lsbG9zaXMgaW4gYSBsZXVrZW1pYSBhbmQgYm9uZSBtYXJyb3cgdHJhbnNwbGFudCB1

bml0PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkluZmVjdCBDb250cm9sIEhvc3AgRXBpZGVtaW9s

PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SW5mZWN0

aW9uIENvbnRyb2wgYW5kIEhvc3BpdGFsIEVwaWRlbWlvbG9neTwvZnVsbC10aXRsZT48YWJici0x

PkluZmVjdC4gQ29udHJvbCBIb3NwLiBFcGlkZW1pb2wuPC9hYmJyLTE+PGFiYnItMj5JbmZlY3Qg

Q29udHJvbCBIb3NwIEVwaWRlbWlvbDwvYWJici0yPjxhYmJyLTM+SW5mZWN0aW9uIENvbnRyb2wg

JmFtcDsgSG9zcGl0YWwgRXBpZGVtaW9sb2d5PC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxwYWdlcz4x

OC0yMzwvcGFnZXM+PHZvbHVtZT4yMTwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxrZXl3b3Jk

cz48a2V5d29yZD5BbmFseXNpcyBvZiBWYXJpYW5jZTwva2V5d29yZD48a2V5d29yZD5Bc3Blcmdp

bGxvc2lzL2VwaWRlbWlvbG9neS8qcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxr

ZXl3b3JkPkJhbHRpbW9yZS9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Qm9uZSBNYXJy

b3cgVHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkNhc2UtQ29udHJvbCBTdHVkaWVz

PC9rZXl3b3JkPjxrZXl3b3JkPkRpc2Vhc2UgT3V0YnJlYWtzLypwcmV2ZW50aW9uICZhbXA7IGNv

bnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+RW52aXJvbm1lbnRhbCBNb25pdG9yaW5nLyptZXRob2Rz

PC9rZXl3b3JkPjxrZXl3b3JkPkVwaWRlbWlvbG9naWNhbCBNb25pdG9yaW5nPC9rZXl3b3JkPjxr

ZXl3b3JkPkZhY2lsaXR5IERlc2lnbiBhbmQgQ29uc3RydWN0aW9uPC9rZXl3b3JkPjxrZXl3b3Jk

PkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5mZWN0

aW9uIENvbnRyb2wvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+TGV1a2VtaWEvKm1pY3JvYmlv

bG9neS90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkxvZ2lzdGljIE1vZGVsczwva2V5d29yZD48

a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3

b3JkPk9kZHMgUmF0aW88L2tleXdvcmQ+PGtleXdvcmQ+UmlzayBGYWN0b3JzPC9rZXl3b3JkPjxr

ZXl3b3JkPlZlbnRpbGF0aW9uPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDA8

L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KYW48L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNi

bj4wODk5LTgyM1ggKFByaW50KSYjeEQ7MDg5OS04MjNYIChMaW5raW5nKTwvaXNibj48YWNjZXNz

aW9uLW51bT4xMDY1NjM0OTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xMDY1NjM0OTwvdXJsPjwvcmVsYXRl

ZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA4Ni81MDE2OTE8L2Vs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhhaG48

L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxSZWNOdW0+Nzk1PC9SZWNOdW0+PHJlY29yZD48cmVj

LW51bWJlcj43OTU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlk

PSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM2

MjA0OCI+Nzk1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IYWhuLCBU

LjwvYXV0aG9yPjxhdXRob3I+Q3VtbWluZ3MsIEsuIE0uPC9hdXRob3I+PGF1dGhvcj5NaWNoYWxl

aywgQS4gTS48L2F1dGhvcj48YXV0aG9yPkxpcG1hbiwgQi4gSi48L2F1dGhvcj48YXV0aG9yPlNl

Z2FsLCBCLiBILjwvYXV0aG9yPjxhdXRob3I+TWNDYXJ0aHksIFAuIEwuLCBKci48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIE1lZGlj

aW5lLCBSb3N3ZWxsIFBhcmsgQ2FuY2VyIEluc3RpdHV0ZSwgQnVmZmFsbywgTmV3IFlvcmsgMTQy

NjMsIFVTQS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5FZmZpY2FjeSBvZiBoaWdoLWVm

ZmljaWVuY3kgcGFydGljdWxhdGUgYWlyIGZpbHRyYXRpb24gaW4gcHJldmVudGluZyBhc3Blcmdp

bGxvc2lzIGluIGltbXVub2NvbXByb21pc2VkIHBhdGllbnRzIHdpdGggaGVtYXRvbG9naWMgbWFs

aWduYW5jaWVzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkluZmVjdCBDb250cm9sIEhvc3AgRXBp

ZGVtaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

SW5mZWN0aW9uIENvbnRyb2wgYW5kIEhvc3BpdGFsIEVwaWRlbWlvbG9neTwvZnVsbC10aXRsZT48

YWJici0xPkluZmVjdC4gQ29udHJvbCBIb3NwLiBFcGlkZW1pb2wuPC9hYmJyLTE+PGFiYnItMj5J

bmZlY3QgQ29udHJvbCBIb3NwIEVwaWRlbWlvbDwvYWJici0yPjxhYmJyLTM+SW5mZWN0aW9uIENv

bnRyb2wgJmFtcDsgSG9zcGl0YWwgRXBpZGVtaW9sb2d5PC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxw

YWdlcz41MjUtMzE8L3BhZ2VzPjx2b2x1bWU+MjM8L3ZvbHVtZT48bnVtYmVyPjk8L251bWJlcj48

a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5

d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9r

ZXl3b3JkPjxrZXl3b3JkPkFpciBDb25kaXRpb25pbmcvKm1ldGhvZHMvc3RhbmRhcmRzPC9rZXl3

b3JkPjxrZXl3b3JkPipBaXIgTWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2ls

bG9zaXMvZXRpb2xvZ3kvKnByZXZlbnRpb24gJmFtcDsgY29udHJvbC90cmFuc21pc3Npb248L2tl

eXdvcmQ+PGtleXdvcmQ+KkFzcGVyZ2lsbHVzIGZsYXZ1czwva2V5d29yZD48a2V5d29yZD5DYW5j

ZXIgQ2FyZSBGYWNpbGl0aWVzPC9rZXl3b3JkPjxrZXl3b3JkPkNyb3NzIEluZmVjdGlvbi9ldGlv

bG9neS8qcHJldmVudGlvbiAmYW1wOyBjb250cm9sL3RyYW5zbWlzc2lvbjwva2V5d29yZD48a2V5

d29yZD5EaXNlYXNlIE91dGJyZWFrcy9wcmV2ZW50aW9uICZhbXA7IGNvbnRyb2wvc3RhdGlzdGlj

cyAmYW1wOyBudW1lcmljYWwgZGF0YTwva2V5d29yZD48a2V5d29yZD5FbnZpcm9ubWVudGFsIE1v

bml0b3Jpbmc8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZpbHRy

YXRpb24vKm1ldGhvZHMvc3RhbmRhcmRzPC9rZXl3b3JkPjxrZXl3b3JkPkhlbWF0b2xvZ2ljIE5l

b3BsYXNtcy8qY29tcGxpY2F0aW9uczwva2V5d29yZD48a2V5d29yZD5Ib3NwaXRhbCBEZXNpZ24g

YW5kIENvbnN0cnVjdGlvbjwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv

cmQ+KkltbXVub2NvbXByb21pc2VkIEhvc3Q8L2tleXdvcmQ+PGtleXdvcmQ+SW5mZWN0aW9uIENv

bnRyb2wvKm1ldGhvZHMvc3RhbmRhcmRzPC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcgRGlzZWFzZXMs

IEZ1bmdhbC9ldGlvbG9neS8qcHJldmVudGlvbiAmYW1wOyBjb250cm9sL3RyYW5zbWlzc2lvbjwv

a2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPk5ldyBZb3JrPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1

ZGllczwva2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48

ZGF0ZXM+PHllYXI+MjAwMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPlNlcDwvZGF0ZT48L3B1Yi1k

YXRlcz48L2RhdGVzPjxpc2JuPjA4OTktODIzWCAoUHJpbnQpJiN4RDswODk5LTgyM1ggKExpbmtp

bmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEyMjY5NDUxPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxy

ZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzEyMjY5

NDUxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4x

MC4xMDg2LzUwMjEwMTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxD

aXRlPjxBdXRob3I+UmF2aXY8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxSZWNOdW0+Nzk2PC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj43OTY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIi

IHRpbWVzdGFtcD0iMTQ1NDM2MjA5MiI+Nzk2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBl

IG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhv

cnM+PGF1dGhvcj5SYXZpdiwgWS48L2F1dGhvcj48YXV0aG9yPktyYW1lciwgTS4gUi48L2F1dGhv

cj48YXV0aG9yPkFtaXRhbCwgQS48L2F1dGhvcj48YXV0aG9yPlJ1Ymlub3ZpdGNoLCBCLjwvYXV0

aG9yPjxhdXRob3I+QmlzaGFyYSwgSi48L2F1dGhvcj48YXV0aG9yPlNoaXRyaXQsIEQuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+UHVsbW9uYXJ5IEluc3Rp

dHV0ZSwgUmFiaW4gTWVkaWNhbCBDZW50ZXIsIFNhY2tsZXIgU2Nob29sIG9mIE1lZGljaW5lLCBU

ZWwtQXZpdiwgSXNyYWVsLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk91dGJyZWFrIG9m

IGFzcGVyZ2lsbG9zaXMgaW5mZWN0aW9ucyBhbW9uZyBsdW5nIHRyYW5zcGxhbnQgcmVjaXBpZW50

czwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5UcmFuc3BsIEludDwvc2Vjb25kYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlRyYW5zcGxhbnQgSW50ZXJuYXRpb25hbDwv

ZnVsbC10aXRsZT48YWJici0xPlRyYW5zcGwuIEludC48L2FiYnItMT48YWJici0yPlRyYW5zcGwg

SW50PC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz4xMzUtNDA8L3BhZ2VzPjx2b2x1bWU+MjA8

L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdv

cmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2NvbXBsaWNh

dGlvbnMvZXBpZGVtaW9sb2d5LypldGlvbG9neTwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIE91

dGJyZWFrczwva2V5d29yZD48a2V5d29yZD5FbnZpcm9ubWVudGFsIEV4cG9zdXJlLyphZHZlcnNl

IGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+RmFjaWxpdHkgRGVzaWduIGFuZCBDb25zdHJ1Y3Rp

b248L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5

d29yZD48a2V5d29yZD5MdW5nIERpc2Vhc2VzLCBGdW5nYWwvY29tcGxpY2F0aW9ucy9lcGlkZW1p

b2xvZ3kvKmV0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcgVHJhbnNwbGFudGF0aW9uLyph

ZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5N

aWRkbGUgQWdlZDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA3PC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+RmViPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDkzNC0w

ODc0IChQcmludCkmI3hEOzA5MzQtMDg3NCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+

MTcyMzkwMjE8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93

d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTcyMzkwMjE8L3VybD48L3JlbGF0ZWQtdXJscz48

L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMTEvai4xNDMyLTIyNzcuMjAwNi4w

MDQxMS54PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1

dGhvcj5QZWxhZXo8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNOdW0+MjUzNTc8L1JlY051

bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI1MzU3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4y

NTM1Nzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi

PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UGVsYWV6LCBULjwv

YXV0aG9yPjxhdXRob3I+TXVub3osIFAuPC9hdXRob3I+PGF1dGhvcj5HdWluZWEsIEouPC9hdXRo

b3I+PGF1dGhvcj5WYWxlcmlvLCBNLjwvYXV0aG9yPjxhdXRob3I+R2lhbm5lbGxhLCBNLjwvYXV0

aG9yPjxhdXRob3I+S2xhYXNzZW4sIEMuIEguPC9hdXRob3I+PGF1dGhvcj5Cb3V6YSwgRS48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9m

IENsaW5pY2FsIE1pY3JvYmlvbG9neSBhbmQgSW5mZWN0aW91cyBEaXNlYXNlcywgSG9zcGl0YWwg

R2VuZXJhbCBVbml2ZXJzaXRhcmlvIEdyZWdvcmlvIE1hcmFub24sIE1hZHJpZCwgU3BhaW4uPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+T3V0YnJlYWsgb2YgaW52YXNpdmUgYXNwZXJnaWxs

b3NpcyBhZnRlciBtYWpvciBoZWFydCBzdXJnZXJ5IGNhdXNlZCBieSBzcG9yZXMgaW4gdGhlIGFp

ciBvZiB0aGUgaW50ZW5zaXZlIGNhcmUgdW5pdDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGlu

IEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGluZmVjdGlv

dXMgZGlzZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlvbiBvZiB0aGUgSW5mZWN0aW91cyBE

aXNlYXNlcyBTb2NpZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5DbGluIEluZmVjdCBEaXM8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxw

YWdlcz5lMjQtMzE8L3BhZ2VzPjx2b2x1bWU+NTQ8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48

ZWRpdGlvbj4yMDEyLzAxLzE3PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkLCA4MCBh

bmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD4qQWlyIE1pY3JvYmlvbG9neTwva2V5d29yZD48a2V5

d29yZD5BbnRpZnVuZ2FsIEFnZW50cy90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+

QXNwZXJnaWxsb3Npcy9kcnVnIHRoZXJhcHkvZXBpZGVtaW9sb2d5LypldGlvbG9neTwva2V5d29y

ZD48a2V5d29yZD5Bc3BlcmdpbGx1cy8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5

d29yZD48a2V5d29yZD5DYXJkaWFjIFN1cmdpY2FsIFByb2NlZHVyZXMvKmFkdmVyc2UgZWZmZWN0

czwva2V5d29yZD48a2V5d29yZD4qQ29yb25hcnkgQ2FyZSBVbml0czwva2V5d29yZD48a2V5d29y

ZD4qRGlzZWFzZSBPdXRicmVha3M8L2tleXdvcmQ+PGtleXdvcmQ+RWNoaW5vY2FuZGlucy90aGVy

YXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1

bWFuczwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwv

a2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5QeXJpbWlkaW5l

cy90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+U3BvcmVzLCBGdW5nYWwvaXNvbGF0

aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5Ucmlhem9sZXMvdGhlcmFw

ZXV0aWMgdXNlPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTI8L3llYXI+PHB1

Yi1kYXRlcz48ZGF0ZT5GZWIgMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1Mzct

NjU5MSAoRWxlY3Ryb25pYykmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MjIyNDczMDc8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0

LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjIyNDczMDc8L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvY2lkL2Npcjc3

MTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNv

cmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA [20-23]. Cases of invasive mould disease with onset of symptoms 7 days or more after hospital admission are more likely to be nosocomial PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Zb2tvZTwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl

Y051bT42MzQ8L1JlY051bT48RGlzcGxheVRleHQ+WzI0XTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj42MzQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQz

OTMxMzc0NCI+NjM0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Zb2tv

ZSwgRC48L2F1dGhvcj48YXV0aG9yPkNhc3BlciwgQy48L2F1dGhvcj48YXV0aG9yPkR1YmJlcmtl

LCBFLjwvYXV0aG9yPjxhdXRob3I+TGVlLCBHLjwvYXV0aG9yPjxhdXRob3I+TXVub3osIFAuPC9h

dXRob3I+PGF1dGhvcj5QYWxtb3JlLCBULjwvYXV0aG9yPjxhdXRob3I+U2Vwa293aXR6LCBLLjwv

YXV0aG9yPjxhdXRob3I+WW91bmcsIEouIEEuPC9hdXRob3I+PGF1dGhvcj5Eb25uZWxseSwgSi4g

UC48L2F1dGhvcj48YXV0aG9yPkNlbnRlciBmb3IgSW50ZXJuYXRpb25hbCwgQmxvb2Q8L2F1dGhv

cj48YXV0aG9yPk1hcnJvdyBUcmFuc3BsYW50LCBSZXNlYXJjaDwvYXV0aG9yPjxhdXRob3I+TmF0

aW9uYWwgTWFycm93IERvbm9yLCBQcm9ncmFtPC9hdXRob3I+PGF1dGhvcj5FdXJvcGVhbiwgQmxv

b2Q8L2F1dGhvcj48YXV0aG9yPk1hcnJvdyBUcmFuc3BsYW50LCBHcm91cDwvYXV0aG9yPjxhdXRo

b3I+QW1lcmljYW4gU29jaWV0eSBvZiwgQmxvb2Q8L2F1dGhvcj48YXV0aG9yPk1hcnJvdywgVHJh

bnNwbGFudGF0aW9uPC9hdXRob3I+PGF1dGhvcj5DYW5hZGlhbiwgQmxvb2Q8L2F1dGhvcj48YXV0

aG9yPk1hcnJvdyBUcmFuc3BsYW50LCBHcm91cDwvYXV0aG9yPjxhdXRob3I+SW5mZWN0aW91cyBE

aXNlYXNlIFNvY2lldHkgb2YsIEFtZXJpY2E8L2F1dGhvcj48YXV0aG9yPlNvY2lldHkgZm9yIEhl

YWx0aGNhcmUgRXBpZGVtaW9sb2d5IG9mLCBBbWVyaWNhPC9hdXRob3I+PGF1dGhvcj5Bc3NvY2lh

dGlvbiBvZiBNZWRpY2FsLCBNaWNyb2Jpb2xvZ3k8L2F1dGhvcj48YXV0aG9yPkluZmVjdGlvdXMg

RGlzZWFzZXMsIENhbmFkYTwvYXV0aG9yPjxhdXRob3I+Q2VudGVycyBmb3IgRGlzZWFzZSwgQ29u

dHJvbDwvYXV0aG9yPjxhdXRob3I+UHJldmVudGlvbiw8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250

cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5CcmlnaGFtICZhbXA7IFdvbWVuJmFwb3M7cyBIb3NwaXRh

bCBhbmQgRGFuYS1GYXJiZXIgQ2FuY2VyIEluc3RpdHV0ZSwgQm9zdG9uLCBNQSAwMjExNSwgVVNB

LiBkZWJvcmFoLnlva29lQGNoYW5uaW5nLmhhcnZhcmQuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+SW5mZWN0aW9uIHByZXZlbnRpb24gYW5kIGNvbnRyb2wgaW4gaGVhbHRoLWNhcmUg

ZmFjaWxpdGllcyBpbiB3aGljaCBoZW1hdG9wb2lldGljIGNlbGwgdHJhbnNwbGFudCByZWNpcGll

bnRzIGFyZSB0cmVhdGVkPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJvbmUgTWFycm93IFRyYW5z

cGxhbnQ8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5C

b25lIE1hcnJvdyBUcmFuc3BsYW50YXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5Cb25lIE1hcnJv

dyBUcmFuc3BsYW50LjwvYWJici0xPjxhYmJyLTI+Qm9uZSBNYXJyb3cgVHJhbnNwbGFudDwvYWJi

ci0yPjwvcGVyaW9kaWNhbD48cGFnZXM+NDk1LTUwNzwvcGFnZXM+PHZvbHVtZT40NDwvdm9sdW1l

PjxudW1iZXI+ODwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD4qSGVtYXRvcG9pZXRpYyBTdGVt

IENlbGwgVHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48

a2V5d29yZD4qSW1tdW5vY29tcHJvbWlzZWQgSG9zdDwva2V5d29yZD48a2V5d29yZD5JbmZlY3Rp

b24gQ29udHJvbC8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5PcHBvcnR1bmlzdGljIEluZmVj

dGlvbnMvaW1tdW5vbG9neS8qcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxrZXl3

b3JkPlZhY2NpbmVzL2NvbnRyYWluZGljYXRpb25zPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVz

Pjx5ZWFyPjIwMDk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5PY3Q8L2RhdGU+PC9wdWItZGF0ZXM+

PC9kYXRlcz48aXNibj4xNDc2LTUzNjUgKEVsZWN0cm9uaWMpJiN4RDswMjY4LTMzNjkgKExpbmtp

bmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE5ODYxOTg0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxy

ZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzE5ODYx

OTg0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4x

MC4xMDM4L2JtdC4yMDA5LjI2MTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9D

aXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Zb2tvZTwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl

Y051bT42MzQ8L1JlY051bT48RGlzcGxheVRleHQ+WzI0XTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj42MzQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQz

OTMxMzc0NCI+NjM0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Zb2tv

ZSwgRC48L2F1dGhvcj48YXV0aG9yPkNhc3BlciwgQy48L2F1dGhvcj48YXV0aG9yPkR1YmJlcmtl

LCBFLjwvYXV0aG9yPjxhdXRob3I+TGVlLCBHLjwvYXV0aG9yPjxhdXRob3I+TXVub3osIFAuPC9h

dXRob3I+PGF1dGhvcj5QYWxtb3JlLCBULjwvYXV0aG9yPjxhdXRob3I+U2Vwa293aXR6LCBLLjwv

YXV0aG9yPjxhdXRob3I+WW91bmcsIEouIEEuPC9hdXRob3I+PGF1dGhvcj5Eb25uZWxseSwgSi4g

UC48L2F1dGhvcj48YXV0aG9yPkNlbnRlciBmb3IgSW50ZXJuYXRpb25hbCwgQmxvb2Q8L2F1dGhv

cj48YXV0aG9yPk1hcnJvdyBUcmFuc3BsYW50LCBSZXNlYXJjaDwvYXV0aG9yPjxhdXRob3I+TmF0

aW9uYWwgTWFycm93IERvbm9yLCBQcm9ncmFtPC9hdXRob3I+PGF1dGhvcj5FdXJvcGVhbiwgQmxv

b2Q8L2F1dGhvcj48YXV0aG9yPk1hcnJvdyBUcmFuc3BsYW50LCBHcm91cDwvYXV0aG9yPjxhdXRo

b3I+QW1lcmljYW4gU29jaWV0eSBvZiwgQmxvb2Q8L2F1dGhvcj48YXV0aG9yPk1hcnJvdywgVHJh

bnNwbGFudGF0aW9uPC9hdXRob3I+PGF1dGhvcj5DYW5hZGlhbiwgQmxvb2Q8L2F1dGhvcj48YXV0

aG9yPk1hcnJvdyBUcmFuc3BsYW50LCBHcm91cDwvYXV0aG9yPjxhdXRob3I+SW5mZWN0aW91cyBE

aXNlYXNlIFNvY2lldHkgb2YsIEFtZXJpY2E8L2F1dGhvcj48YXV0aG9yPlNvY2lldHkgZm9yIEhl

YWx0aGNhcmUgRXBpZGVtaW9sb2d5IG9mLCBBbWVyaWNhPC9hdXRob3I+PGF1dGhvcj5Bc3NvY2lh

dGlvbiBvZiBNZWRpY2FsLCBNaWNyb2Jpb2xvZ3k8L2F1dGhvcj48YXV0aG9yPkluZmVjdGlvdXMg

RGlzZWFzZXMsIENhbmFkYTwvYXV0aG9yPjxhdXRob3I+Q2VudGVycyBmb3IgRGlzZWFzZSwgQ29u

dHJvbDwvYXV0aG9yPjxhdXRob3I+UHJldmVudGlvbiw8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250

cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5CcmlnaGFtICZhbXA7IFdvbWVuJmFwb3M7cyBIb3NwaXRh

bCBhbmQgRGFuYS1GYXJiZXIgQ2FuY2VyIEluc3RpdHV0ZSwgQm9zdG9uLCBNQSAwMjExNSwgVVNB

LiBkZWJvcmFoLnlva29lQGNoYW5uaW5nLmhhcnZhcmQuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+SW5mZWN0aW9uIHByZXZlbnRpb24gYW5kIGNvbnRyb2wgaW4gaGVhbHRoLWNhcmUg

ZmFjaWxpdGllcyBpbiB3aGljaCBoZW1hdG9wb2lldGljIGNlbGwgdHJhbnNwbGFudCByZWNpcGll

bnRzIGFyZSB0cmVhdGVkPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJvbmUgTWFycm93IFRyYW5z

cGxhbnQ8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5C

b25lIE1hcnJvdyBUcmFuc3BsYW50YXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5Cb25lIE1hcnJv

dyBUcmFuc3BsYW50LjwvYWJici0xPjxhYmJyLTI+Qm9uZSBNYXJyb3cgVHJhbnNwbGFudDwvYWJi

ci0yPjwvcGVyaW9kaWNhbD48cGFnZXM+NDk1LTUwNzwvcGFnZXM+PHZvbHVtZT40NDwvdm9sdW1l

PjxudW1iZXI+ODwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD4qSGVtYXRvcG9pZXRpYyBTdGVt

IENlbGwgVHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48

a2V5d29yZD4qSW1tdW5vY29tcHJvbWlzZWQgSG9zdDwva2V5d29yZD48a2V5d29yZD5JbmZlY3Rp

b24gQ29udHJvbC8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5PcHBvcnR1bmlzdGljIEluZmVj

dGlvbnMvaW1tdW5vbG9neS8qcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxrZXl3

b3JkPlZhY2NpbmVzL2NvbnRyYWluZGljYXRpb25zPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVz

Pjx5ZWFyPjIwMDk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5PY3Q8L2RhdGU+PC9wdWItZGF0ZXM+

PC9kYXRlcz48aXNibj4xNDc2LTUzNjUgKEVsZWN0cm9uaWMpJiN4RDswMjY4LTMzNjkgKExpbmtp

bmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE5ODYxOTg0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxy

ZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzE5ODYx

OTg0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4x

MC4xMDM4L2JtdC4yMDA5LjI2MTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9D

aXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA [24]. In the absence of an outbreak with an identified environmental source (e.g. a contaminated air vent) or molecular analysis that demonstrates clustering of fungal isolates, it is not possible to reliably distinguish community-acquired from nosocomial aspergillosis. As a quality control measure, leukemia and transplant centers should perform regular surveillance (e.g. every 3 months) documenting the number of invasive mould infections within their institution. Due to the paucity of culture confirmed cases of IA and lack of autopsy data in most medical centers, surveillance using case definitions for moulds including GM and radiographic evidence of infection such as the revised European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) criteria is reasonable. An increase in incidence over baseline or the occurrence of invasive mould infections in patients who are not considered high-risk for such infections should prompt evaluation for a hospital source. Environmental sampling can provide important insight about sources of aspergillosis, including the spread of azole-resistant strains PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVyIExpbmRlbjwvQXV0aG9yPjxZZWFyPjIwMTM8

L1llYXI+PFJlY051bT4yMjA5ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTcsIDI1XTwvRGlzcGxh

eVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4yMjA5ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRl

cCI+MjIwOTg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRp

Y2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPnZhbiBkZXIg

TGluZGVuLCBKLiBXLjwvYXV0aG9yPjxhdXRob3I+Q2FtcHMsIFMuIE0uPC9hdXRob3I+PGF1dGhv

cj5LYW1waW5nYSwgRy4gQS48L2F1dGhvcj48YXV0aG9yPkFyZW5kcywgSi4gUC48L2F1dGhvcj48

YXV0aG9yPkRlYmV0cy1Pc3NlbmtvcHAsIFkuIEouPC9hdXRob3I+PGF1dGhvcj5IYWFzLCBQLiBK

LjwvYXV0aG9yPjxhdXRob3I+UmlqbmRlcnMsIEIuIEouPC9hdXRob3I+PGF1dGhvcj5LdWlqcGVy

LCBFLiBKLjwvYXV0aG9yPjxhdXRob3I+dmFuIFRpZWwsIEYuIEguPC9hdXRob3I+PGF1dGhvcj5W

YXJnYSwgSi48L2F1dGhvcj48YXV0aG9yPkthcmF3YWpjenlrLCBBLjwvYXV0aG9yPjxhdXRob3I+

Wm9sbCwgSi48L2F1dGhvcj48YXV0aG9yPk1lbGNoZXJzLCBXLiBKLjwvYXV0aG9yPjxhdXRob3I+

VmVyd2VpaiwgUC4gRS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRk

cmVzcz5EZXBhcnRtZW50IG9mIE1lZGljYWwgTWljcm9iaW9sb2d5LCBSYWRib3VkIFVuaXZlcnNp

dHkgTmlqbWVnZW4gTWVkaWNhbCBDZW50cmUsIE5pam1lZ2VuLCBUaGUgTmV0aGVybGFuZHMuPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QXNwZXJnaWxsb3NpcyBkdWUgdG8gdm9yaWNvbmF6

b2xlIGhpZ2hseSByZXNpc3RhbnQgQXNwZXJnaWxsdXMgZnVtaWdhdHVzIGFuZCByZWNvdmVyeSBv

ZiBnZW5ldGljYWxseSByZWxhdGVkIHJlc2lzdGFudCBpc29sYXRlcyBmcm9tIGRvbWljaWxlczwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48

YWx0LXRpdGxlPkNsaW5pY2FsIGluZmVjdGlvdXMgZGlzZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJs

aWNhdGlvbiBvZiB0aGUgSW5mZWN0aW91cyBEaXNlYXNlcyBTb2NpZXR5IG9mIEFtZXJpY2E8L2Fs

dC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DbGluIEluZmVjdCBEaXM8

L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz41MTMtMjA8L3BhZ2VzPjx2b2x1bWU+NTc8

L3ZvbHVtZT48bnVtYmVyPjQ8L251bWJlcj48ZWRpdGlvbj4yMDEzLzA1LzE1PC9lZGl0aW9uPjxr

ZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPipBaXIgTWljcm9iaW9sb2d5

PC9rZXl3b3JkPjxrZXl3b3JkPkFudGlmdW5nYWwgQWdlbnRzL3BoYXJtYWNvbG9neS90aGVyYXBl

dXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzL2RydWcg

dGhlcmFweS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMgZnVtaWdh

dHVzL2NsYXNzaWZpY2F0aW9uL2RydWcgZWZmZWN0cy9nZW5ldGljcy8qaXNvbGF0aW9uICZhbXA7

PC9rZXl3b3JkPjxrZXl3b3JkPnB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5DaGlsZDwv

a2V5d29yZD48a2V5d29yZD4qRHJ1ZyBSZXNpc3RhbmNlLCBGdW5nYWw8L2tleXdvcmQ+PGtleXdv

cmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkdlbmVzLCBGdW5nYWw8L2tleXdvcmQ+PGtleXdv

cmQ+R2Vub3R5cGU8L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWxzPC9rZXl3b3JkPjxrZXl3b3Jk

Pkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBB

Z2VkPC9rZXl3b3JkPjxrZXl3b3JkPipNb2xlY3VsYXIgVHlwaW5nPC9rZXl3b3JkPjxrZXl3b3Jk

Pk15Y29sb2dpY2FsIFR5cGluZyBUZWNobmlxdWVzPC9rZXl3b3JkPjxrZXl3b3JkPk5ldGhlcmxh

bmRzPC9rZXl3b3JkPjxrZXl3b3JkPlB5cmltaWRpbmVzLypwaGFybWFjb2xvZ3kvdGhlcmFwZXV0

aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPlF1ZXN0aW9ubmFpcmVzPC9rZXl3b3JkPjxrZXl3b3Jk

PipSZXNpZGVuY2UgQ2hhcmFjdGVyaXN0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPlNlbGVjdGlvbiwg

R2VuZXRpYzwva2V5d29yZD48a2V5d29yZD5TZXF1ZW5jZSBBbmFseXNpcywgRE5BPC9rZXl3b3Jk

PjxrZXl3b3JkPlRyZWF0bWVudCBGYWlsdXJlPC9rZXl3b3JkPjxrZXl3b3JkPlRyaWF6b2xlcy8q

cGhhcm1hY29sb2d5L3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Zb3VuZyBBZHVs

dDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjxwdWItZGF0ZXM+

PGRhdGU+QXVnPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVj

dHJvbmljKSYjeEQ7MTA1OC00ODM4IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMzY2

NzI2MzwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMu

IEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3

dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMzY2NzI2MzwvdXJsPjwvcmVsYXRlZC11cmxzPjwv

dXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9jaWQvY2l0MzIwPC9lbGVjdHJv

bmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+

PENpdGU+PEF1dGhvcj5XYXJyaXM8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxSZWNOdW0+MjUz

MjI8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI1MzIyPC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJk

eHpwdGVwIj4yNTMyMjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+V2Fy

cmlzLCBBLjwvYXV0aG9yPjxhdXRob3I+S2xhYXNzZW4sIEMuIEguPC9hdXRob3I+PGF1dGhvcj5N

ZWlzLCBKLiBGLjwvYXV0aG9yPjxhdXRob3I+RGUgUnVpdGVyLCBNLiBULjwvYXV0aG9yPjxhdXRo

b3I+RGUgVmFsaywgSC4gQS48L2F1dGhvcj48YXV0aG9yPkFicmFoYW1zZW4sIFQuIEcuPC9hdXRo

b3I+PGF1dGhvcj5HYXVzdGFkLCBQLjwvYXV0aG9yPjxhdXRob3I+VmVyd2VpaiwgUC4gRS48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9m

IFBlZGlhdHJpY3MsIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIgU3QuIFJhZGJvdWQsIE5pam1l

Z2VuLCBUaGUgTmV0aGVybGFuZHMuIEEuV2FycmlzQGVyYXNtdXNtYy5ubDwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPk1vbGVjdWxhciBlcGlkZW1pb2xvZ3kgb2YgQXNwZXJnaWxsdXMgZnVt

aWdhdHVzIGlzb2xhdGVzIHJlY292ZXJlZCBmcm9tIHdhdGVyLCBhaXIsIGFuZCBwYXRpZW50cyBz

aG93cyB0d28gY2x1c3RlcnMgb2YgZ2VuZXRpY2FsbHkgZGlzdGluY3Qgc3RyYWluczwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5KIENsaW4gTWljcm9iaW9sPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10

aXRsZT5Kb3VybmFsIG9mIGNsaW5pY2FsIG1pY3JvYmlvbG9neTwvYWx0LXRpdGxlPjwvdGl0bGVz

PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQ2xpbiBNaWNyb2Jpb2w8L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxwYWdlcz40MTAxLTY8L3BhZ2VzPjx2b2x1bWU+NDE8L3ZvbHVtZT48bnVtYmVy

Pjk8L251bWJlcj48ZWRpdGlvbj4yMDAzLzA5LzA2PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29y

ZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPipBaXIgTWlj

cm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvKm1pY3JvYmlvbG9neTwv

a2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cyBmdW1pZ2F0dXMvY2xhc3NpZmljYXRpb24vKmdl

bmV0aWNzL2lzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+RE5B

IEZpbmdlcnByaW50aW5nPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29y

ZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD4qV2F0ZXIgTWljcm9iaW9sb2d5PC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDM8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5T

ZXA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDk1LTExMzcgKFByaW50KSYjeEQ7

MDA5NS0xMTM3IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMjk1ODIzMjwvYWNjZXNz

aW9uLW51bT48d29yay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8

L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5u

aWguZ292L3B1Ym1lZC8xMjk1ODIzMjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9t

Mj4xOTM3OTI8L2N1c3RvbTI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVyIExpbmRlbjwvQXV0aG9yPjxZZWFyPjIwMTM8

L1llYXI+PFJlY051bT4yMjA5ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTcsIDI1XTwvRGlzcGxh

eVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4yMjA5ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRl

cCI+MjIwOTg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRp

Y2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPnZhbiBkZXIg

TGluZGVuLCBKLiBXLjwvYXV0aG9yPjxhdXRob3I+Q2FtcHMsIFMuIE0uPC9hdXRob3I+PGF1dGhv

cj5LYW1waW5nYSwgRy4gQS48L2F1dGhvcj48YXV0aG9yPkFyZW5kcywgSi4gUC48L2F1dGhvcj48

YXV0aG9yPkRlYmV0cy1Pc3NlbmtvcHAsIFkuIEouPC9hdXRob3I+PGF1dGhvcj5IYWFzLCBQLiBK

LjwvYXV0aG9yPjxhdXRob3I+UmlqbmRlcnMsIEIuIEouPC9hdXRob3I+PGF1dGhvcj5LdWlqcGVy

LCBFLiBKLjwvYXV0aG9yPjxhdXRob3I+dmFuIFRpZWwsIEYuIEguPC9hdXRob3I+PGF1dGhvcj5W

YXJnYSwgSi48L2F1dGhvcj48YXV0aG9yPkthcmF3YWpjenlrLCBBLjwvYXV0aG9yPjxhdXRob3I+

Wm9sbCwgSi48L2F1dGhvcj48YXV0aG9yPk1lbGNoZXJzLCBXLiBKLjwvYXV0aG9yPjxhdXRob3I+

VmVyd2VpaiwgUC4gRS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRk

cmVzcz5EZXBhcnRtZW50IG9mIE1lZGljYWwgTWljcm9iaW9sb2d5LCBSYWRib3VkIFVuaXZlcnNp

dHkgTmlqbWVnZW4gTWVkaWNhbCBDZW50cmUsIE5pam1lZ2VuLCBUaGUgTmV0aGVybGFuZHMuPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QXNwZXJnaWxsb3NpcyBkdWUgdG8gdm9yaWNvbmF6

b2xlIGhpZ2hseSByZXNpc3RhbnQgQXNwZXJnaWxsdXMgZnVtaWdhdHVzIGFuZCByZWNvdmVyeSBv

ZiBnZW5ldGljYWxseSByZWxhdGVkIHJlc2lzdGFudCBpc29sYXRlcyBmcm9tIGRvbWljaWxlczwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48

YWx0LXRpdGxlPkNsaW5pY2FsIGluZmVjdGlvdXMgZGlzZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJs

aWNhdGlvbiBvZiB0aGUgSW5mZWN0aW91cyBEaXNlYXNlcyBTb2NpZXR5IG9mIEFtZXJpY2E8L2Fs

dC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DbGluIEluZmVjdCBEaXM8

L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz41MTMtMjA8L3BhZ2VzPjx2b2x1bWU+NTc8

L3ZvbHVtZT48bnVtYmVyPjQ8L251bWJlcj48ZWRpdGlvbj4yMDEzLzA1LzE1PC9lZGl0aW9uPjxr

ZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPipBaXIgTWljcm9iaW9sb2d5

PC9rZXl3b3JkPjxrZXl3b3JkPkFudGlmdW5nYWwgQWdlbnRzL3BoYXJtYWNvbG9neS90aGVyYXBl

dXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzL2RydWcg

dGhlcmFweS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMgZnVtaWdh

dHVzL2NsYXNzaWZpY2F0aW9uL2RydWcgZWZmZWN0cy9nZW5ldGljcy8qaXNvbGF0aW9uICZhbXA7

PC9rZXl3b3JkPjxrZXl3b3JkPnB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5DaGlsZDwv

a2V5d29yZD48a2V5d29yZD4qRHJ1ZyBSZXNpc3RhbmNlLCBGdW5nYWw8L2tleXdvcmQ+PGtleXdv

cmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkdlbmVzLCBGdW5nYWw8L2tleXdvcmQ+PGtleXdv

cmQ+R2Vub3R5cGU8L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWxzPC9rZXl3b3JkPjxrZXl3b3Jk

Pkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBB

Z2VkPC9rZXl3b3JkPjxrZXl3b3JkPipNb2xlY3VsYXIgVHlwaW5nPC9rZXl3b3JkPjxrZXl3b3Jk

Pk15Y29sb2dpY2FsIFR5cGluZyBUZWNobmlxdWVzPC9rZXl3b3JkPjxrZXl3b3JkPk5ldGhlcmxh

bmRzPC9rZXl3b3JkPjxrZXl3b3JkPlB5cmltaWRpbmVzLypwaGFybWFjb2xvZ3kvdGhlcmFwZXV0

aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPlF1ZXN0aW9ubmFpcmVzPC9rZXl3b3JkPjxrZXl3b3Jk

PipSZXNpZGVuY2UgQ2hhcmFjdGVyaXN0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPlNlbGVjdGlvbiwg

R2VuZXRpYzwva2V5d29yZD48a2V5d29yZD5TZXF1ZW5jZSBBbmFseXNpcywgRE5BPC9rZXl3b3Jk

PjxrZXl3b3JkPlRyZWF0bWVudCBGYWlsdXJlPC9rZXl3b3JkPjxrZXl3b3JkPlRyaWF6b2xlcy8q

cGhhcm1hY29sb2d5L3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Zb3VuZyBBZHVs

dDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjxwdWItZGF0ZXM+

PGRhdGU+QXVnPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVj

dHJvbmljKSYjeEQ7MTA1OC00ODM4IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMzY2

NzI2MzwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMu

IEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3

dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMzY2NzI2MzwvdXJsPjwvcmVsYXRlZC11cmxzPjwv

dXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9jaWQvY2l0MzIwPC9lbGVjdHJv

bmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+

PENpdGU+PEF1dGhvcj5XYXJyaXM8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxSZWNOdW0+MjUz

MjI8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI1MzIyPC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJk

eHpwdGVwIj4yNTMyMjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+V2Fy

cmlzLCBBLjwvYXV0aG9yPjxhdXRob3I+S2xhYXNzZW4sIEMuIEguPC9hdXRob3I+PGF1dGhvcj5N

ZWlzLCBKLiBGLjwvYXV0aG9yPjxhdXRob3I+RGUgUnVpdGVyLCBNLiBULjwvYXV0aG9yPjxhdXRo

b3I+RGUgVmFsaywgSC4gQS48L2F1dGhvcj48YXV0aG9yPkFicmFoYW1zZW4sIFQuIEcuPC9hdXRo

b3I+PGF1dGhvcj5HYXVzdGFkLCBQLjwvYXV0aG9yPjxhdXRob3I+VmVyd2VpaiwgUC4gRS48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9m

IFBlZGlhdHJpY3MsIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIgU3QuIFJhZGJvdWQsIE5pam1l

Z2VuLCBUaGUgTmV0aGVybGFuZHMuIEEuV2FycmlzQGVyYXNtdXNtYy5ubDwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPk1vbGVjdWxhciBlcGlkZW1pb2xvZ3kgb2YgQXNwZXJnaWxsdXMgZnVt

aWdhdHVzIGlzb2xhdGVzIHJlY292ZXJlZCBmcm9tIHdhdGVyLCBhaXIsIGFuZCBwYXRpZW50cyBz

aG93cyB0d28gY2x1c3RlcnMgb2YgZ2VuZXRpY2FsbHkgZGlzdGluY3Qgc3RyYWluczwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5KIENsaW4gTWljcm9iaW9sPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10

aXRsZT5Kb3VybmFsIG9mIGNsaW5pY2FsIG1pY3JvYmlvbG9neTwvYWx0LXRpdGxlPjwvdGl0bGVz

PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQ2xpbiBNaWNyb2Jpb2w8L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxwYWdlcz40MTAxLTY8L3BhZ2VzPjx2b2x1bWU+NDE8L3ZvbHVtZT48bnVtYmVy

Pjk8L251bWJlcj48ZWRpdGlvbj4yMDAzLzA5LzA2PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29y

ZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPipBaXIgTWlj

cm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvKm1pY3JvYmlvbG9neTwv

a2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cyBmdW1pZ2F0dXMvY2xhc3NpZmljYXRpb24vKmdl

bmV0aWNzL2lzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+RE5B

IEZpbmdlcnByaW50aW5nPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29y

ZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD4qV2F0ZXIgTWljcm9iaW9sb2d5PC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDM8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5T

ZXA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDk1LTExMzcgKFByaW50KSYjeEQ7

MDA5NS0xMTM3IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMjk1ODIzMjwvYWNjZXNz

aW9uLW51bT48d29yay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8

L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5u

aWguZ292L3B1Ym1lZC8xMjk1ODIzMjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9t

Mj4xOTM3OTI8L2N1c3RvbTI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA [17, 25] although there is debate whether such surveillance is of value for routine patient care PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYW5nbmV1eDwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+

PFJlY051bT4yNTIyNTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMjYsIDI3XTwvRGlzcGxheVRleHQ+

PHJlY29yZD48cmVjLW51bWJlcj4yNTIyNTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+MjUy

MjU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x

NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkdhbmduZXV4LCBKLiBQ

LjwvYXV0aG9yPjxhdXRob3I+QnJldGFnbmUsIFMuPC9hdXRob3I+PGF1dGhvcj5Db3Jkb25uaWVy

LCBDLjwvYXV0aG9yPjxhdXRob3I+RGF0cnksIEEuPC9hdXRob3I+PGF1dGhvcj5EZXJvdWluLCBG

LjwvYXV0aG9yPjxhdXRob3I+R3JpbGxvdCwgUi48L2F1dGhvcj48YXV0aG9yPkthdWZmbWFubi1M

YWNyb2l4LCBDLjwvYXV0aG9yPjxhdXRob3I+TGViZWF1LCBCLjwvYXV0aG9yPjxhdXRob3I+TW9y

aW4sIE8uPC9hdXRob3I+PGF1dGhvcj5OaWNvbGxlLCBNLiBDLjwvYXV0aG9yPjxhdXRob3I+UGll

bnMsIE0uIEEuPC9hdXRob3I+PGF1dGhvcj5Qb2lyb3QsIEouIEwuPC9hdXRob3I+PC9hdXRob3Jz

PjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPlByZXZlbnRpb24gb2Ygbm9zb2NvbWlhbCBm

dW5nYWwgaW5mZWN0aW9uOiB0aGUgRnJlbmNoIGFwcHJvYWNoPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkNsaW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwg

aW5mZWN0aW91cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZl

Y3Rpb3VzIERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW4gSW5mZWN0IERpczwvZnVsbC10aXRsZT48L3Blcmlv

ZGljYWw+PHBhZ2VzPjM0My02PC9wYWdlcz48dm9sdW1lPjM1PC92b2x1bWU+PG51bWJlcj4zPC9u

dW1iZXI+PGVkaXRpb24+MjAwMi8wNy8xMzwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWly

IFBvbGx1dGlvbiwgSW5kb29yPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvKnByZXZl

bnRpb24gJmFtcDsgY29udHJvbDwva2V5d29yZD48a2V5d29yZD5Dcm9zcyBJbmZlY3Rpb24vbWlj

cm9iaW9sb2d5LypwcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+RnJh

bmNlL2VwaWRlbWlvbG9neTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv

cmQ+UHJpbWFyeSBQcmV2ZW50aW9uLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlNwb3Jlcywg

RnVuZ2FsPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDI8L3llYXI+PHB1Yi1k

YXRlcz48ZGF0ZT5BdWcgMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzctNjU5

MSAoRWxlY3Ryb25pYykmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+MTIxMTUxMDY8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5Db21tZW50JiN4RDtMZXR0ZXI8

L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5u

aWguZ292L3B1Ym1lZC8xMjExNTEwNjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+MTAuMTA4Ni8zNDEzMTg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt

PjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhh

amplaDwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+PFJlY051bT4yNTI3OTwvUmVjTnVtPjxyZWNv

cmQ+PHJlYy1udW1iZXI+MjUyNzk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI1Mjc5PC9r

ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl

Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IYWpqZWgsIFIuIEEuPC9hdXRo

b3I+PGF1dGhvcj5XYXJub2NrLCBELiBXLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPk15Y290aWMgRGlzZWFzZXMgQnJhbmNoLCBEaXZpc2lvbiBvZiBCYWN0

ZXJpYWwgYW5kIE15Y290aWMgRGlzZWFzZXMsIE5hdGlvbmFsIENlbnRlciBmb3IgSW5mZWN0aW91

cyBEaXNlYXNlcywgQ2VudGVycyBmb3IgRGlzZWFzZSBDb250cm9sIGFuZCBQcmV2ZW50aW9uLCBB

dGxhbnRhLCBHQSAzMDMzMywgVVNBLiByaGFqamVoQGNkYy5nb3Y8L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5Db3VudGVycG9pbnQ6IGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgYW5kIHRoZSBl

bnZpcm9ubWVudC0tcmV0aGlua2luZyBvdXIgYXBwcm9hY2ggdG8gcHJldmVudGlvbjwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5DbGluIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRp

dGxlPkNsaW5pY2FsIGluZmVjdGlvdXMgZGlzZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlv

biBvZiB0aGUgSW5mZWN0aW91cyBEaXNlYXNlcyBTb2NpZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRs

ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DbGluIEluZmVjdCBEaXM8L2Z1bGwt

dGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4xNTQ5LTUyPC9wYWdlcz48dm9sdW1lPjMzPC92b2x1

bWU+PG51bWJlcj45PC9udW1iZXI+PGVkaXRpb24+MjAwMS8wOS8yNTwvZWRpdGlvbj48a2V5d29y

ZHM+PGtleXdvcmQ+QWlyPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvKmVwaWRlbWlv

bG9neS9wcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxs

dXM8L2tleXdvcmQ+PGtleXdvcmQ+Q3Jvc3MgSW5mZWN0aW9uLyplcGlkZW1pb2xvZ3kvcHJldmVu

dGlvbiAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxrZXl3b3JkPipFbnZpcm9ubWVudGFsIEV4cG9z

dXJlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5XYXRlciBTdXBw

bHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMTwveWVhcj48cHViLWRhdGVz

PjxkYXRlPk5vdiAxPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA1OC00ODM4IChQ

cmludCkmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTE1Njg4

NTQ8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5Db21tZW50JiN4RDtSZXZpZXc8L3dvcmstdHlw

ZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1

Ym1lZC8xMTU2ODg1NDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTA4Ni8zMjI5NzA8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFn

ZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYW5nbmV1eDwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+

PFJlY051bT4yNTIyNTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMjYsIDI3XTwvRGlzcGxheVRleHQ+

PHJlY29yZD48cmVjLW51bWJlcj4yNTIyNTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+MjUy

MjU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x

NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkdhbmduZXV4LCBKLiBQ

LjwvYXV0aG9yPjxhdXRob3I+QnJldGFnbmUsIFMuPC9hdXRob3I+PGF1dGhvcj5Db3Jkb25uaWVy

LCBDLjwvYXV0aG9yPjxhdXRob3I+RGF0cnksIEEuPC9hdXRob3I+PGF1dGhvcj5EZXJvdWluLCBG

LjwvYXV0aG9yPjxhdXRob3I+R3JpbGxvdCwgUi48L2F1dGhvcj48YXV0aG9yPkthdWZmbWFubi1M

YWNyb2l4LCBDLjwvYXV0aG9yPjxhdXRob3I+TGViZWF1LCBCLjwvYXV0aG9yPjxhdXRob3I+TW9y

aW4sIE8uPC9hdXRob3I+PGF1dGhvcj5OaWNvbGxlLCBNLiBDLjwvYXV0aG9yPjxhdXRob3I+UGll

bnMsIE0uIEEuPC9hdXRob3I+PGF1dGhvcj5Qb2lyb3QsIEouIEwuPC9hdXRob3I+PC9hdXRob3Jz

PjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPlByZXZlbnRpb24gb2Ygbm9zb2NvbWlhbCBm

dW5nYWwgaW5mZWN0aW9uOiB0aGUgRnJlbmNoIGFwcHJvYWNoPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkNsaW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwg

aW5mZWN0aW91cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZl

Y3Rpb3VzIERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW4gSW5mZWN0IERpczwvZnVsbC10aXRsZT48L3Blcmlv

ZGljYWw+PHBhZ2VzPjM0My02PC9wYWdlcz48dm9sdW1lPjM1PC92b2x1bWU+PG51bWJlcj4zPC9u

dW1iZXI+PGVkaXRpb24+MjAwMi8wNy8xMzwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWly

IFBvbGx1dGlvbiwgSW5kb29yPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvKnByZXZl

bnRpb24gJmFtcDsgY29udHJvbDwva2V5d29yZD48a2V5d29yZD5Dcm9zcyBJbmZlY3Rpb24vbWlj

cm9iaW9sb2d5LypwcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+RnJh

bmNlL2VwaWRlbWlvbG9neTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv

cmQ+UHJpbWFyeSBQcmV2ZW50aW9uLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlNwb3Jlcywg

RnVuZ2FsPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDI8L3llYXI+PHB1Yi1k

YXRlcz48ZGF0ZT5BdWcgMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzctNjU5

MSAoRWxlY3Ryb25pYykmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+MTIxMTUxMDY8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5Db21tZW50JiN4RDtMZXR0ZXI8

L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5u

aWguZ292L3B1Ym1lZC8xMjExNTEwNjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+MTAuMTA4Ni8zNDEzMTg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt

PjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhh

amplaDwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+PFJlY051bT4yNTI3OTwvUmVjTnVtPjxyZWNv

cmQ+PHJlYy1udW1iZXI+MjUyNzk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI1Mjc5PC9r

ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl

Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IYWpqZWgsIFIuIEEuPC9hdXRo

b3I+PGF1dGhvcj5XYXJub2NrLCBELiBXLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPk15Y290aWMgRGlzZWFzZXMgQnJhbmNoLCBEaXZpc2lvbiBvZiBCYWN0

ZXJpYWwgYW5kIE15Y290aWMgRGlzZWFzZXMsIE5hdGlvbmFsIENlbnRlciBmb3IgSW5mZWN0aW91

cyBEaXNlYXNlcywgQ2VudGVycyBmb3IgRGlzZWFzZSBDb250cm9sIGFuZCBQcmV2ZW50aW9uLCBB

dGxhbnRhLCBHQSAzMDMzMywgVVNBLiByaGFqamVoQGNkYy5nb3Y8L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5Db3VudGVycG9pbnQ6IGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgYW5kIHRoZSBl

bnZpcm9ubWVudC0tcmV0aGlua2luZyBvdXIgYXBwcm9hY2ggdG8gcHJldmVudGlvbjwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5DbGluIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRp

dGxlPkNsaW5pY2FsIGluZmVjdGlvdXMgZGlzZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlv

biBvZiB0aGUgSW5mZWN0aW91cyBEaXNlYXNlcyBTb2NpZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRs

ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DbGluIEluZmVjdCBEaXM8L2Z1bGwt

dGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4xNTQ5LTUyPC9wYWdlcz48dm9sdW1lPjMzPC92b2x1

bWU+PG51bWJlcj45PC9udW1iZXI+PGVkaXRpb24+MjAwMS8wOS8yNTwvZWRpdGlvbj48a2V5d29y

ZHM+PGtleXdvcmQ+QWlyPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvKmVwaWRlbWlv

bG9neS9wcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxs

dXM8L2tleXdvcmQ+PGtleXdvcmQ+Q3Jvc3MgSW5mZWN0aW9uLyplcGlkZW1pb2xvZ3kvcHJldmVu

dGlvbiAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxrZXl3b3JkPipFbnZpcm9ubWVudGFsIEV4cG9z

dXJlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5XYXRlciBTdXBw

bHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMTwveWVhcj48cHViLWRhdGVz

PjxkYXRlPk5vdiAxPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA1OC00ODM4IChQ

cmludCkmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTE1Njg4

NTQ8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5Db21tZW50JiN4RDtSZXZpZXc8L3dvcmstdHlw

ZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1

Ym1lZC8xMTU2ODg1NDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTA4Ni8zMjI5NzA8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFn

ZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA [26, 27]. In the absence of an outbreak, there is insufficient evidence that environmental sampling of fungal spores is of value. In the setting of a documented or suspected nosocomial outbreak, a number of measures should be undertaken, including evaluation of the ventilation system to ensure adequate filtration, air flow, maintenance of positive pressure, and consideration of environmental sampling e.g., air vents and water system.What acquired or inherited defects in host immunity increase the risk of aspergillosis? Patients at risk for IA include those with prolonged neutropenia, allogeneic HSCT recipients, solid organ transplant recipients, patients receiving corticosteroids, advanced acquired immunodeficiency syndrome (AIDS), and CGD. In patients with hematologic malignancies, myelodysplastic syndrome, and other diseases associated with marrow failure (e.g., aplastic anemia), the intensity and duration of neutropenia predict the risk of IA PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XZWluYmVyZ2VyPC9BdXRob3I+PFllYXI+MTk5MjwvWWVh

cj48UmVjTnVtPjI2MDYwPC9SZWNOdW0+PERpc3BsYXlUZXh0PlsyOCwgMjldPC9EaXNwbGF5VGV4

dD48cmVjb3JkPjxyZWMtbnVtYmVyPjI2MDYwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4y

NjA2MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi

PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+V2VpbmJlcmdlciwg

TS48L2F1dGhvcj48YXV0aG9yPkVsYXR0YXIsIEkuPC9hdXRob3I+PGF1dGhvcj5NYXJzaGFsbCwg

RC48L2F1dGhvcj48YXV0aG9yPlN0ZWluYmVyZywgUy4gTS48L2F1dGhvcj48YXV0aG9yPlJlZG5l

ciwgUi4gTC48L2F1dGhvcj48YXV0aG9yPllvdW5nLCBOLiBTLjwvYXV0aG9yPjxhdXRob3I+UGl6

em8sIFAuIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+

SW5mZWN0aW91cyBEaXNlYXNlIFNlY3Rpb24sIE5hdGlvbmFsIENhbmNlciBJbnN0aXR1dGUsIE5h

dGlvbmFsIEluc3RpdHV0ZXMgb2YgSGVhbHRoLCBCZXRoZXNkYSwgTWFyeWxhbmQgMjA4OTIuPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UGF0dGVybnMgb2YgaW5mZWN0aW9uIGluIHBhdGll

bnRzIHdpdGggYXBsYXN0aWMgYW5lbWlhIGFuZCB0aGUgZW1lcmdlbmNlIG9mIEFzcGVyZ2lsbHVz

IGFzIGEgbWFqb3IgY2F1c2Ugb2YgZGVhdGg8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TWVkaWNp

bmUgKEJhbHRpbW9yZSk8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPk1lZGljaW5lPC9hbHQt

dGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TWVkaWNpbmUgKEJhbHRpbW9y

ZSk8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4yNC00MzwvcGFnZXM+PHZvbHVtZT43

MTwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxlZGl0aW9uPjE5OTIvMDEvMDE8L2VkaXRpb24+

PGtleXdvcmRzPjxrZXl3b3JkPkFnZSBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPkFuZW1pYSwg

QXBsYXN0aWMvKmNvbXBsaWNhdGlvbnMvbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVy

Z2lsbG9zaXMvZXBpZGVtaW9sb2d5L2V0aW9sb2d5Lyptb3J0YWxpdHk8L2tleXdvcmQ+PGtleXdv

cmQ+Q2F1c2Ugb2YgRGVhdGg8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpLVNxdWFyZSBEaXN0cmlidXRp

b248L2tleXdvcmQ+PGtleXdvcmQ+Q3Jvc3MgSW5mZWN0aW9uL2VwaWRlbWlvbG9neS9ldGlvbG9n

eS8qbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkZldmVyL2VwaWRlbWlvbG9neS9ldGlvbG9n

eTwva2V5d29yZD48a2V5d29yZD5GZXZlciBvZiBVbmtub3duIE9yaWdpbi9lcGlkZW1pb2xvZ3kv

ZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluY2lk

ZW5jZTwva2V5d29yZD48a2V5d29yZD5OYXRpb25hbCBJbnN0aXR1dGVzIG9mIEhlYWx0aCAoVS5T

Lik8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3

b3JkPlVuaXRlZCBTdGF0ZXMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVz

Pjx5ZWFyPjE5OTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KYW48L2RhdGU+PC9wdWItZGF0ZXM+

PC9kYXRlcz48aXNibj4wMDI1LTc5NzQgKFByaW50KSYjeEQ7MDAyNS03OTc0IChMaW5raW5nKTwv

aXNibj48YWNjZXNzaW9uLW51bT4xNTQ5MDU3PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q29t

cGFyYXRpdmUgU3R1ZHk8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xNTQ5MDU3PC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0

aG9yPkdlcnNvbjwvQXV0aG9yPjxZZWFyPjE5ODQ8L1llYXI+PFJlY051bT4yNjA3ODwvUmVjTnVt

PjxyZWNvcmQ+PHJlYy1udW1iZXI+MjYwNzg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5

IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI2

MDc4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5HZXJzb24sIFMuIEwu

PC9hdXRob3I+PGF1dGhvcj5UYWxib3QsIEcuIEguPC9hdXRob3I+PGF1dGhvcj5IdXJ3aXR6LCBT

LjwvYXV0aG9yPjxhdXRob3I+U3Ryb20sIEIuIEwuPC9hdXRob3I+PGF1dGhvcj5MdXNrLCBFLiBK

LjwvYXV0aG9yPjxhdXRob3I+Q2Fzc2lsZXRoLCBQLiBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5Qcm9sb25nZWQgZ3JhbnVsb2N5dG9wZW5pYTogdGhl

IG1ham9yIHJpc2sgZmFjdG9yIGZvciBpbnZhc2l2ZSBwdWxtb25hcnkgYXNwZXJnaWxsb3NpcyBp

biBwYXRpZW50cyB3aXRoIGFjdXRlIGxldWtlbWlhPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFu

biBJbnRlcm4gTWVkPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Bbm5hbHMgb2YgaW50ZXJu

YWwgbWVkaWNpbmU8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5B

bm4gSW50ZXJuIE1lZDwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjM0NS01MTwvcGFn

ZXM+PHZvbHVtZT4xMDA8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48ZWRpdGlvbj4xOTg0LzAz

LzAxPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BY3V0ZSBEaXNlYXNlPC9rZXl3b3JkPjxr

ZXl3b3JkPkFncmFudWxvY3l0b3Npcy9jaGVtaWNhbGx5IGluZHVjZWQvKmNvbXBsaWNhdGlvbnM8

L2tleXdvcmQ+PGtleXdvcmQ+QW50aW5lb3BsYXN0aWMgQWdlbnRzL2FkdmVyc2UgZWZmZWN0czwv

a2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzLypldGlvbG9neTwva2V5d29yZD48a2V5d29y

ZD5CbG9vZCBUcmFuc2Z1c2lvbi9hZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+RXBp

ZGVtaW9sb2dpYyBNZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5

d29yZD5MZXVrZW1pYS9ibG9vZC8qY29tcGxpY2F0aW9ucy9kcnVnIHRoZXJhcHk8L2tleXdvcmQ+

PGtleXdvcmQ+THVuZyBEaXNlYXNlcywgRnVuZ2FsLypldGlvbG9neTwva2V5d29yZD48a2V5d29y

ZD5SaXNrPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48L2tleXdvcmRz

PjxkYXRlcz48eWVhcj4xOTg0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAwMy00ODE5IChQcmludCkmI3hEOzAwMDMtNDgxOSAoTGlu

a2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+NjY5NjM1NjwvYWNjZXNzaW9uLW51bT48d29yay10

eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3QmI3hEO1Jlc2VhcmNoIFN1

cHBvcnQsIFUuUy4gR292JmFwb3M7dCwgUC5ILlMuPC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQt

dXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvNjY5NjM1NjwvdXJs

PjwvcmVsYXRlZC11cmxzPjwvdXJscz48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48

L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XZWluYmVyZ2VyPC9BdXRob3I+PFllYXI+MTk5MjwvWWVh

cj48UmVjTnVtPjI2MDYwPC9SZWNOdW0+PERpc3BsYXlUZXh0PlsyOCwgMjldPC9EaXNwbGF5VGV4

dD48cmVjb3JkPjxyZWMtbnVtYmVyPjI2MDYwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4y

NjA2MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi

PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+V2VpbmJlcmdlciwg

TS48L2F1dGhvcj48YXV0aG9yPkVsYXR0YXIsIEkuPC9hdXRob3I+PGF1dGhvcj5NYXJzaGFsbCwg

RC48L2F1dGhvcj48YXV0aG9yPlN0ZWluYmVyZywgUy4gTS48L2F1dGhvcj48YXV0aG9yPlJlZG5l

ciwgUi4gTC48L2F1dGhvcj48YXV0aG9yPllvdW5nLCBOLiBTLjwvYXV0aG9yPjxhdXRob3I+UGl6

em8sIFAuIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+

SW5mZWN0aW91cyBEaXNlYXNlIFNlY3Rpb24sIE5hdGlvbmFsIENhbmNlciBJbnN0aXR1dGUsIE5h

dGlvbmFsIEluc3RpdHV0ZXMgb2YgSGVhbHRoLCBCZXRoZXNkYSwgTWFyeWxhbmQgMjA4OTIuPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UGF0dGVybnMgb2YgaW5mZWN0aW9uIGluIHBhdGll

bnRzIHdpdGggYXBsYXN0aWMgYW5lbWlhIGFuZCB0aGUgZW1lcmdlbmNlIG9mIEFzcGVyZ2lsbHVz

IGFzIGEgbWFqb3IgY2F1c2Ugb2YgZGVhdGg8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TWVkaWNp

bmUgKEJhbHRpbW9yZSk8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPk1lZGljaW5lPC9hbHQt

dGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TWVkaWNpbmUgKEJhbHRpbW9y

ZSk8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4yNC00MzwvcGFnZXM+PHZvbHVtZT43

MTwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxlZGl0aW9uPjE5OTIvMDEvMDE8L2VkaXRpb24+

PGtleXdvcmRzPjxrZXl3b3JkPkFnZSBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPkFuZW1pYSwg

QXBsYXN0aWMvKmNvbXBsaWNhdGlvbnMvbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVy

Z2lsbG9zaXMvZXBpZGVtaW9sb2d5L2V0aW9sb2d5Lyptb3J0YWxpdHk8L2tleXdvcmQ+PGtleXdv

cmQ+Q2F1c2Ugb2YgRGVhdGg8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpLVNxdWFyZSBEaXN0cmlidXRp

b248L2tleXdvcmQ+PGtleXdvcmQ+Q3Jvc3MgSW5mZWN0aW9uL2VwaWRlbWlvbG9neS9ldGlvbG9n

eS8qbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkZldmVyL2VwaWRlbWlvbG9neS9ldGlvbG9n

eTwva2V5d29yZD48a2V5d29yZD5GZXZlciBvZiBVbmtub3duIE9yaWdpbi9lcGlkZW1pb2xvZ3kv

ZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluY2lk

ZW5jZTwva2V5d29yZD48a2V5d29yZD5OYXRpb25hbCBJbnN0aXR1dGVzIG9mIEhlYWx0aCAoVS5T

Lik8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3

b3JkPlVuaXRlZCBTdGF0ZXMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVz

Pjx5ZWFyPjE5OTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KYW48L2RhdGU+PC9wdWItZGF0ZXM+

PC9kYXRlcz48aXNibj4wMDI1LTc5NzQgKFByaW50KSYjeEQ7MDAyNS03OTc0IChMaW5raW5nKTwv

aXNibj48YWNjZXNzaW9uLW51bT4xNTQ5MDU3PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q29t

cGFyYXRpdmUgU3R1ZHk8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xNTQ5MDU3PC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0

aG9yPkdlcnNvbjwvQXV0aG9yPjxZZWFyPjE5ODQ8L1llYXI+PFJlY051bT4yNjA3ODwvUmVjTnVt

PjxyZWNvcmQ+PHJlYy1udW1iZXI+MjYwNzg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5

IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI2

MDc4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5HZXJzb24sIFMuIEwu

PC9hdXRob3I+PGF1dGhvcj5UYWxib3QsIEcuIEguPC9hdXRob3I+PGF1dGhvcj5IdXJ3aXR6LCBT

LjwvYXV0aG9yPjxhdXRob3I+U3Ryb20sIEIuIEwuPC9hdXRob3I+PGF1dGhvcj5MdXNrLCBFLiBK

LjwvYXV0aG9yPjxhdXRob3I+Q2Fzc2lsZXRoLCBQLiBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5Qcm9sb25nZWQgZ3JhbnVsb2N5dG9wZW5pYTogdGhl

IG1ham9yIHJpc2sgZmFjdG9yIGZvciBpbnZhc2l2ZSBwdWxtb25hcnkgYXNwZXJnaWxsb3NpcyBp

biBwYXRpZW50cyB3aXRoIGFjdXRlIGxldWtlbWlhPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFu

biBJbnRlcm4gTWVkPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Bbm5hbHMgb2YgaW50ZXJu

YWwgbWVkaWNpbmU8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5B

bm4gSW50ZXJuIE1lZDwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjM0NS01MTwvcGFn

ZXM+PHZvbHVtZT4xMDA8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48ZWRpdGlvbj4xOTg0LzAz

LzAxPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BY3V0ZSBEaXNlYXNlPC9rZXl3b3JkPjxr

ZXl3b3JkPkFncmFudWxvY3l0b3Npcy9jaGVtaWNhbGx5IGluZHVjZWQvKmNvbXBsaWNhdGlvbnM8

L2tleXdvcmQ+PGtleXdvcmQ+QW50aW5lb3BsYXN0aWMgQWdlbnRzL2FkdmVyc2UgZWZmZWN0czwv

a2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzLypldGlvbG9neTwva2V5d29yZD48a2V5d29y

ZD5CbG9vZCBUcmFuc2Z1c2lvbi9hZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+RXBp

ZGVtaW9sb2dpYyBNZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5

d29yZD5MZXVrZW1pYS9ibG9vZC8qY29tcGxpY2F0aW9ucy9kcnVnIHRoZXJhcHk8L2tleXdvcmQ+

PGtleXdvcmQ+THVuZyBEaXNlYXNlcywgRnVuZ2FsLypldGlvbG9neTwva2V5d29yZD48a2V5d29y

ZD5SaXNrPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48L2tleXdvcmRz

PjxkYXRlcz48eWVhcj4xOTg0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAwMy00ODE5IChQcmludCkmI3hEOzAwMDMtNDgxOSAoTGlu

a2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+NjY5NjM1NjwvYWNjZXNzaW9uLW51bT48d29yay10

eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3QmI3hEO1Jlc2VhcmNoIFN1

cHBvcnQsIFUuUy4gR292JmFwb3M7dCwgUC5ILlMuPC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQt

dXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvNjY5NjM1NjwvdXJs

PjwvcmVsYXRlZC11cmxzPjwvdXJscz48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48

L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [28, 29]. Patients with refractory or relapsed acute leukemia treated with re-induction regimens are at particularly high risk for IA and other mould infections. Allogeneic HSCT recipients have a significantly higher risk of IA and other opportunistic infections compared to autologous HSCT recipients PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb250b3lpYW5uaXM8L0F1dGhvcj48WWVhcj4yMDEwPC9Z

ZWFyPjxSZWNOdW0+MTc5NTE8L1JlY051bT48RGlzcGxheVRleHQ+WzMwXTwvRGlzcGxheVRleHQ+

PHJlY29yZD48cmVjLW51bWJlcj4xNzk1MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+MTc5

NTE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x

NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPktvbnRveWlhbm5pcywg

RC4gUC48L2F1dGhvcj48YXV0aG9yPk1hcnIsIEsuIEEuPC9hdXRob3I+PGF1dGhvcj5QYXJrLCBC

LiBKLjwvYXV0aG9yPjxhdXRob3I+QWxleGFuZGVyLCBCLiBELjwvYXV0aG9yPjxhdXRob3I+QW5h

aXNzaWUsIEUuIEouPC9hdXRob3I+PGF1dGhvcj5XYWxzaCwgVC4gSi48L2F1dGhvcj48YXV0aG9y

Pkl0bywgSi48L2F1dGhvcj48YXV0aG9yPkFuZGVzLCBELiBSLjwvYXV0aG9yPjxhdXRob3I+QmFk

ZGxleSwgSi4gVy48L2F1dGhvcj48YXV0aG9yPkJyb3duLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+

QnJ1bWJsZSwgTC4gTS48L2F1dGhvcj48YXV0aG9yPkZyZWlmZWxkLCBBLiBHLjwvYXV0aG9yPjxh

dXRob3I+SGFkbGV5LCBTLjwvYXV0aG9yPjxhdXRob3I+SGVyd2FsZHQsIEwuIEEuPC9hdXRob3I+

PGF1dGhvcj5LYXVmZm1hbiwgQy4gQS48L2F1dGhvcj48YXV0aG9yPktuYXBwLCBLLjwvYXV0aG9y

PjxhdXRob3I+THlvbiwgRy4gTS48L2F1dGhvcj48YXV0aG9yPk1vcnJpc29uLCBWLiBBLjwvYXV0

aG9yPjxhdXRob3I+UGFwYW5pY29sYW91LCBHLjwvYXV0aG9yPjxhdXRob3I+UGF0dGVyc29uLCBU

LiBGLjwvYXV0aG9yPjxhdXRob3I+UGVybCwgVC4gTS48L2F1dGhvcj48YXV0aG9yPlNjaHVzdGVy

LCBNLiBHLjwvYXV0aG9yPjxhdXRob3I+V2Fsa2VyLCBSLjwvYXV0aG9yPjxhdXRob3I+V2FubmVt

dWVobGVyLCBLLiBBLjwvYXV0aG9yPjxhdXRob3I+V2luZ2FyZCwgSi4gUi48L2F1dGhvcj48YXV0

aG9yPkNoaWxsZXIsIFQuIE0uPC9hdXRob3I+PGF1dGhvcj5QYXBwYXMsIFAuIEcuPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VGhlIFVuaXZlcnNpdHkgb2Yg

VGV4YXMgTUQgQW5kZXJzb24gQ2FuY2VyIENlbnRlciwgSG91c3RvbiwgVGV4YXMsIFVTQS4gZGtv

bnRveWlAbWRhbmRlcnNvbi5vcmc8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Qcm9zcGVj

dGl2ZSBzdXJ2ZWlsbGFuY2UgZm9yIGludmFzaXZlIGZ1bmdhbCBpbmZlY3Rpb25zIGluIGhlbWF0

b3BvaWV0aWMgc3RlbSBjZWxsIHRyYW5zcGxhbnQgcmVjaXBpZW50cywgMjAwMS0yMDA2OiBvdmVy

dmlldyBvZiB0aGUgVHJhbnNwbGFudC1Bc3NvY2lhdGVkIEluZmVjdGlvbiBTdXJ2ZWlsbGFuY2Ug

TmV0d29yayAoVFJBTlNORVQpIERhdGFiYXNlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW4g

SW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwgaW5mZWN0aW91

cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZlY3Rpb3VzIERp

c2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkNsaW4gSW5mZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBh

Z2VzPjEwOTEtMTAwPC9wYWdlcz48dm9sdW1lPjUwPC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+

PGVkaXRpb24+MjAxMC8wMy8xMjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2Vu

dDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3Jk

PjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkLCBQcmVzY2hvb2w8L2tleXdv

cmQ+PGtleXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3

b3JkPjxrZXl3b3JkPkhlbWF0b3BvaWV0aWMgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbi8qYWR2

ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4q

SW1tdW5vY29tcHJvbWlzZWQgSG9zdDwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8L2tleXdv

cmQ+PGtleXdvcmQ+SW5mYW50PC9rZXl3b3JkPjxrZXl3b3JkPkluZmVjdGlvbiBDb250cm9sLypv

cmdhbml6YXRpb24gJmFtcDsgYWRtaW5pc3RyYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwv

a2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5NeWNvc2VzLypl

cGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29y

ZD48a2V5d29yZD4qU2VudGluZWwgU3VydmVpbGxhbmNlPC9rZXl3b3JkPjxrZXl3b3JkPlVuaXRl

ZCBTdGF0ZXMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPllvdW5nIEFkdWx0PC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5B

cHIgMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9u

aWMpJiN4RDsxMDU4LTQ4MzggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMjE4ODc3

PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgVS5TLiBHb3YmYXBv

czt0LCBQLkguUy48L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3

dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMDIxODg3NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwv

dXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA4Ni82NTEyNjM8L2VsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0Vu

ZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb250b3lpYW5uaXM8L0F1dGhvcj48WWVhcj4yMDEwPC9Z

ZWFyPjxSZWNOdW0+MTc5NTE8L1JlY051bT48RGlzcGxheVRleHQ+WzMwXTwvRGlzcGxheVRleHQ+

PHJlY29yZD48cmVjLW51bWJlcj4xNzk1MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+MTc5

NTE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x

NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPktvbnRveWlhbm5pcywg

RC4gUC48L2F1dGhvcj48YXV0aG9yPk1hcnIsIEsuIEEuPC9hdXRob3I+PGF1dGhvcj5QYXJrLCBC

LiBKLjwvYXV0aG9yPjxhdXRob3I+QWxleGFuZGVyLCBCLiBELjwvYXV0aG9yPjxhdXRob3I+QW5h

aXNzaWUsIEUuIEouPC9hdXRob3I+PGF1dGhvcj5XYWxzaCwgVC4gSi48L2F1dGhvcj48YXV0aG9y

Pkl0bywgSi48L2F1dGhvcj48YXV0aG9yPkFuZGVzLCBELiBSLjwvYXV0aG9yPjxhdXRob3I+QmFk

ZGxleSwgSi4gVy48L2F1dGhvcj48YXV0aG9yPkJyb3duLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+

QnJ1bWJsZSwgTC4gTS48L2F1dGhvcj48YXV0aG9yPkZyZWlmZWxkLCBBLiBHLjwvYXV0aG9yPjxh

dXRob3I+SGFkbGV5LCBTLjwvYXV0aG9yPjxhdXRob3I+SGVyd2FsZHQsIEwuIEEuPC9hdXRob3I+

PGF1dGhvcj5LYXVmZm1hbiwgQy4gQS48L2F1dGhvcj48YXV0aG9yPktuYXBwLCBLLjwvYXV0aG9y

PjxhdXRob3I+THlvbiwgRy4gTS48L2F1dGhvcj48YXV0aG9yPk1vcnJpc29uLCBWLiBBLjwvYXV0

aG9yPjxhdXRob3I+UGFwYW5pY29sYW91LCBHLjwvYXV0aG9yPjxhdXRob3I+UGF0dGVyc29uLCBU

LiBGLjwvYXV0aG9yPjxhdXRob3I+UGVybCwgVC4gTS48L2F1dGhvcj48YXV0aG9yPlNjaHVzdGVy

LCBNLiBHLjwvYXV0aG9yPjxhdXRob3I+V2Fsa2VyLCBSLjwvYXV0aG9yPjxhdXRob3I+V2FubmVt

dWVobGVyLCBLLiBBLjwvYXV0aG9yPjxhdXRob3I+V2luZ2FyZCwgSi4gUi48L2F1dGhvcj48YXV0

aG9yPkNoaWxsZXIsIFQuIE0uPC9hdXRob3I+PGF1dGhvcj5QYXBwYXMsIFAuIEcuPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VGhlIFVuaXZlcnNpdHkgb2Yg

VGV4YXMgTUQgQW5kZXJzb24gQ2FuY2VyIENlbnRlciwgSG91c3RvbiwgVGV4YXMsIFVTQS4gZGtv

bnRveWlAbWRhbmRlcnNvbi5vcmc8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Qcm9zcGVj

dGl2ZSBzdXJ2ZWlsbGFuY2UgZm9yIGludmFzaXZlIGZ1bmdhbCBpbmZlY3Rpb25zIGluIGhlbWF0

b3BvaWV0aWMgc3RlbSBjZWxsIHRyYW5zcGxhbnQgcmVjaXBpZW50cywgMjAwMS0yMDA2OiBvdmVy

dmlldyBvZiB0aGUgVHJhbnNwbGFudC1Bc3NvY2lhdGVkIEluZmVjdGlvbiBTdXJ2ZWlsbGFuY2Ug

TmV0d29yayAoVFJBTlNORVQpIERhdGFiYXNlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW4g

SW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwgaW5mZWN0aW91

cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZlY3Rpb3VzIERp

c2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkNsaW4gSW5mZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBh

Z2VzPjEwOTEtMTAwPC9wYWdlcz48dm9sdW1lPjUwPC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+

PGVkaXRpb24+MjAxMC8wMy8xMjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2Vu

dDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3Jk

PjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkLCBQcmVzY2hvb2w8L2tleXdv

cmQ+PGtleXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3

b3JkPjxrZXl3b3JkPkhlbWF0b3BvaWV0aWMgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbi8qYWR2

ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4q

SW1tdW5vY29tcHJvbWlzZWQgSG9zdDwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8L2tleXdv

cmQ+PGtleXdvcmQ+SW5mYW50PC9rZXl3b3JkPjxrZXl3b3JkPkluZmVjdGlvbiBDb250cm9sLypv

cmdhbml6YXRpb24gJmFtcDsgYWRtaW5pc3RyYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwv

a2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5NeWNvc2VzLypl

cGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29y

ZD48a2V5d29yZD4qU2VudGluZWwgU3VydmVpbGxhbmNlPC9rZXl3b3JkPjxrZXl3b3JkPlVuaXRl

ZCBTdGF0ZXMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPllvdW5nIEFkdWx0PC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5B

cHIgMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9u

aWMpJiN4RDsxMDU4LTQ4MzggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMjE4ODc3

PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgVS5TLiBHb3YmYXBv

czt0LCBQLkguUy48L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3

dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMDIxODg3NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwv

dXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA4Ni82NTEyNjM8L2VsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0Vu

ZE5vdGU+AG==

ADDIN EN.CITE.DATA [30]. In allogeneic HSCT recipients, three periods of risk for invasive mould disease occur: 1) neutropenia following the conditioning regimen; 2) exogenous immunosuppression for treatment of acute GVHD; and 3) exogenous immunosuppression for treatment of chronic GVHD (after day 100 of transplant). The level of allogeneic donor and recipient HLA disparity is the major determinant for GVHD severity and intensity of immunosuppression to control GVHD, which, in turn, is the major predisposing factor for opportunistic fungal infections PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb250b3lpYW5uaXM8L0F1dGhvcj48WWVhcj4yMDEwPC9Z

ZWFyPjxSZWNOdW0+MTc5NTE8L1JlY051bT48RGlzcGxheVRleHQ+WzMwLTMyXTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xNzk1MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+

MTc5NTE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl

Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPktvbnRveWlhbm5p

cywgRC4gUC48L2F1dGhvcj48YXV0aG9yPk1hcnIsIEsuIEEuPC9hdXRob3I+PGF1dGhvcj5QYXJr

LCBCLiBKLjwvYXV0aG9yPjxhdXRob3I+QWxleGFuZGVyLCBCLiBELjwvYXV0aG9yPjxhdXRob3I+

QW5haXNzaWUsIEUuIEouPC9hdXRob3I+PGF1dGhvcj5XYWxzaCwgVC4gSi48L2F1dGhvcj48YXV0

aG9yPkl0bywgSi48L2F1dGhvcj48YXV0aG9yPkFuZGVzLCBELiBSLjwvYXV0aG9yPjxhdXRob3I+

QmFkZGxleSwgSi4gVy48L2F1dGhvcj48YXV0aG9yPkJyb3duLCBKLiBNLjwvYXV0aG9yPjxhdXRo

b3I+QnJ1bWJsZSwgTC4gTS48L2F1dGhvcj48YXV0aG9yPkZyZWlmZWxkLCBBLiBHLjwvYXV0aG9y

PjxhdXRob3I+SGFkbGV5LCBTLjwvYXV0aG9yPjxhdXRob3I+SGVyd2FsZHQsIEwuIEEuPC9hdXRo

b3I+PGF1dGhvcj5LYXVmZm1hbiwgQy4gQS48L2F1dGhvcj48YXV0aG9yPktuYXBwLCBLLjwvYXV0

aG9yPjxhdXRob3I+THlvbiwgRy4gTS48L2F1dGhvcj48YXV0aG9yPk1vcnJpc29uLCBWLiBBLjwv

YXV0aG9yPjxhdXRob3I+UGFwYW5pY29sYW91LCBHLjwvYXV0aG9yPjxhdXRob3I+UGF0dGVyc29u

LCBULiBGLjwvYXV0aG9yPjxhdXRob3I+UGVybCwgVC4gTS48L2F1dGhvcj48YXV0aG9yPlNjaHVz

dGVyLCBNLiBHLjwvYXV0aG9yPjxhdXRob3I+V2Fsa2VyLCBSLjwvYXV0aG9yPjxhdXRob3I+V2Fu

bmVtdWVobGVyLCBLLiBBLjwvYXV0aG9yPjxhdXRob3I+V2luZ2FyZCwgSi4gUi48L2F1dGhvcj48

YXV0aG9yPkNoaWxsZXIsIFQuIE0uPC9hdXRob3I+PGF1dGhvcj5QYXBwYXMsIFAuIEcuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VGhlIFVuaXZlcnNpdHkg

b2YgVGV4YXMgTUQgQW5kZXJzb24gQ2FuY2VyIENlbnRlciwgSG91c3RvbiwgVGV4YXMsIFVTQS4g

ZGtvbnRveWlAbWRhbmRlcnNvbi5vcmc8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Qcm9z

cGVjdGl2ZSBzdXJ2ZWlsbGFuY2UgZm9yIGludmFzaXZlIGZ1bmdhbCBpbmZlY3Rpb25zIGluIGhl

bWF0b3BvaWV0aWMgc3RlbSBjZWxsIHRyYW5zcGxhbnQgcmVjaXBpZW50cywgMjAwMS0yMDA2OiBv

dmVydmlldyBvZiB0aGUgVHJhbnNwbGFudC1Bc3NvY2lhdGVkIEluZmVjdGlvbiBTdXJ2ZWlsbGFu

Y2UgTmV0d29yayAoVFJBTlNORVQpIERhdGFiYXNlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNs

aW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwgaW5mZWN0

aW91cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZlY3Rpb3Vz

IERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPkNsaW4gSW5mZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+

PHBhZ2VzPjEwOTEtMTAwPC9wYWdlcz48dm9sdW1lPjUwPC92b2x1bWU+PG51bWJlcj44PC9udW1i

ZXI+PGVkaXRpb24+MjAxMC8wMy8xMjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVz

Y2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkLCBQcmVzY2hvb2w8L2tl

eXdvcmQ+PGtleXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9r

ZXl3b3JkPjxrZXl3b3JkPkhlbWF0b3BvaWV0aWMgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbi8q

YWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29y

ZD4qSW1tdW5vY29tcHJvbWlzZWQgSG9zdDwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8L2tl

eXdvcmQ+PGtleXdvcmQ+SW5mYW50PC9rZXl3b3JkPjxrZXl3b3JkPkluZmVjdGlvbiBDb250cm9s

Lypvcmdhbml6YXRpb24gJmFtcDsgYWRtaW5pc3RyYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+TWFs

ZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5NeWNvc2Vz

LyplcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5

d29yZD48a2V5d29yZD4qU2VudGluZWwgU3VydmVpbGxhbmNlPC9rZXl3b3JkPjxrZXl3b3JkPlVu

aXRlZCBTdGF0ZXMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPllvdW5nIEFkdWx0PC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5BcHIgMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0

cm9uaWMpJiN4RDsxMDU4LTQ4MzggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMjE4

ODc3PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgVS5TLiBHb3Ym

YXBvczt0LCBQLkguUy48L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMDIxODg3NzwvdXJsPjwvcmVsYXRlZC11cmxz

PjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA4Ni82NTEyNjM8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48

Q2l0ZT48QXV0aG9yPkphbnR1bmVuPC9BdXRob3I+PFllYXI+MTk5NzwvWWVhcj48UmVjTnVtPjI2

MTg0PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yNjE4NDwvcmVjLW51bWJlcj48Zm9yZWln

bi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcy

ZHh6cHRlcCI+MjYxODQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkph

bnR1bmVuLCBFLjwvYXV0aG9yPjxhdXRob3I+UnV1dHUsIFAuPC9hdXRob3I+PGF1dGhvcj5OaXNr

YW5lbiwgTC48L2F1dGhvcj48YXV0aG9yPlZvbGluLCBMLjwvYXV0aG9yPjxhdXRob3I+UGFya2th

bGksIFQuPC9hdXRob3I+PGF1dGhvcj5Lb3VraWxhLUthaGtvbGEsIFAuPC9hdXRob3I+PGF1dGhv

cj5SdXV0dSwgVC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5EZXBhcnRtZW50IG9mIE1lZGljaW5lLCBIZWxzaW5raSBVbml2ZXJzaXR5IENlbnRyYWwgSG9z

cGl0YWwsIEZpbmxhbmQuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+SW5jaWRlbmNlIGFu

ZCByaXNrIGZhY3RvcnMgZm9yIGludmFzaXZlIGZ1bmdhbCBpbmZlY3Rpb25zIGluIGFsbG9nZW5l

aWMgQk1UIHJlY2lwaWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qm9uZSBNYXJyb3cgVHJh

bnNwbGFudDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Qm9uZSBtYXJyb3cgdHJhbnNwbGFu

dGF0aW9uPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Qm9uZSBN

YXJyb3cgVHJhbnNwbGFudDwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjgwMS04PC9w

YWdlcz48dm9sdW1lPjE5PC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PGVkaXRpb24+MTk5Ny8w

NC8wMTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWN1dGUgRGlzZWFzZTwva2V5d29yZD48

a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3

b3JkPkFzcGVyZ2lsbG9zaXMvZXBpZGVtaW9sb2d5L2V0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3Jk

PkJvbmUgTWFycm93IFRyYW5zcGxhbnRhdGlvbi8qYWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxr

ZXl3b3JkPkNocm9uaWMgRGlzZWFzZTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+

PGtleXdvcmQ+R3JhZnQgdnMgSG9zdCBEaXNlYXNlL2NvbXBsaWNhdGlvbnMvZHJ1ZyB0aGVyYXB5

L2V0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkhlbWF0b2xvZ2ljIERpc2Vhc2VzL3RoZXJhcHk8

L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub3N1cHByZXNz

aXZlIEFnZW50cy9hZHZlcnNlIGVmZmVjdHMvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3

b3JkPkxldWtlbWlhL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5

d29yZD5NZXRoeWxwcmVkbmlzb2xvbmUvYWR2ZXJzZSBlZmZlY3RzL3RoZXJhcGV1dGljIHVzZTwv

a2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5NeWNvc2VzL2Vw

aWRlbWlvbG9neS8qZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVk

aWVzPC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5UaXNz

dWUgRG9ub3JzPC9rZXl3b3JkPjxrZXl3b3JkPlRyYW5zcGxhbnRhdGlvbiwgSG9tb2xvZ291czwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk3PC95ZWFyPjxwdWItZGF0ZXM+PGRh

dGU+QXByPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDI2OC0zMzY5IChQcmludCkm

I3hEOzAyNjgtMzM2OSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+OTEzNDE3MjwvYWNj

ZXNzaW9uLW51bT48d29yay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9z

O3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5s

bS5uaWguZ292L3B1Ym1lZC85MTM0MTcyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVj

dHJvbmljLXJlc291cmNlLW51bT4xMC4xMDM4L3NqLmJtdC4xNzAwNzM3PC9lbGVjdHJvbmljLXJl

c291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+

PEF1dGhvcj5NYXJyPC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48UmVjTnVtPjI2MTkwPC9SZWNO

dW0+PHJlY29yZD48cmVjLW51bWJlcj4yNjE5MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+

MjYxOTA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl

Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1hcnIsIEsuIEEu

PC9hdXRob3I+PGF1dGhvcj5DYXJ0ZXIsIFIuIEEuPC9hdXRob3I+PGF1dGhvcj5Cb2Vja2gsIE0u

PC9hdXRob3I+PGF1dGhvcj5NYXJ0aW4sIFAuPC9hdXRob3I+PGF1dGhvcj5Db3JleSwgTC48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5GcmVkIEh1dGNoaW5z

b24gQ2FuY2VyIFJlc2VhcmNoIENlbnRlciBQcm9ncmFtcyBpbiBJbmZlY3Rpb3VzIERpc2Vhc2Vz

IGFuZCBMb25nLXRlcm0gRm9sbG93LXVwLCBTZWF0dGxlLCBXQSA5ODEwOSwgVVNBLiBrbWFyckBm

aGNyYy5vcmc8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnZhc2l2ZSBhc3BlcmdpbGxv

c2lzIGluIGFsbG9nZW5laWMgc3RlbSBjZWxsIHRyYW5zcGxhbnQgcmVjaXBpZW50czogY2hhbmdl

cyBpbiBlcGlkZW1pb2xvZ3kgYW5kIHJpc2sgZmFjdG9yczwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5CbG9vZDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Qmxvb2Q8L2FsdC10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CbG9vZDwvZnVsbC10aXRsZT48L3BlcmlvZGlj

YWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJsb29kPC9mdWxsLXRpdGxlPjwvYWx0LXBl

cmlvZGljYWw+PHBhZ2VzPjQzNTgtNjY8L3BhZ2VzPjx2b2x1bWU+MTAwPC92b2x1bWU+PG51bWJl

cj4xMzwvbnVtYmVyPjxlZGl0aW9uPjIwMDIvMTAvMjQ8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3

b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWRyZW5hbCBDb3J0ZXggSG9ybW9uZXMv

YWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkFnZSBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QXNw

ZXJnaWxsb3Npcy8qZXBpZGVtaW9sb2d5L2V0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkJvbmUg

TWFycm93IFRyYW5zcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+

Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29y

ZD5Db2hvcnQgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5DeXRvbWVnYWxvdmlydXMgSW5mZWN0

aW9ucy9lcGlkZW1pb2xvZ3kvZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3

b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkdyYWZ0IHZz

IEhvc3QgRGlzZWFzZS9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvbG9naWMg

TmVvcGxhc21zL2NvbXBsaWNhdGlvbnMvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+KkhlbWF0

b3BvaWV0aWMgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVjdHM8L2tleXdv

cmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub3N1cHByZXNzaW9uL2Fk

dmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5JbW11bm9zdXBwcmVzc2l2ZSBBZ2VudHMv

YWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkluY2lkZW5jZTwva2V5d29yZD48a2V5

d29yZD5JbmZhbnQ8L2tleXdvcmQ+PGtleXdvcmQ+TGlmZSBUYWJsZXM8L2tleXdvcmQ+PGtleXdv

cmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5O

ZXV0cm9wZW5pYS9jaGVtaWNhbGx5IGluZHVjZWQvY29tcGxpY2F0aW9uczwva2V5d29yZD48a2V5

d29yZD5QZXJpcGhlcmFsIEJsb29kIFN0ZW0gQ2VsbCBUcmFuc3BsYW50YXRpb24vYWR2ZXJzZSBl

ZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IFRyYWN0IEluZmVjdGlvbnMvZXBp

ZGVtaW9sb2d5L2V0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29y

ZD48a2V5d29yZD5TdXJ2aXZhbCBBbmFseXNpczwva2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3Rv

cnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJhbnNwbGFudGF0aW9uIENvbmRpdGlvbmluZy9hZHZlcnNl

IGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+VHJhbnNwbGFudGF0aW9uLCBIb21vbG9nb3VzPC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5EZWMgMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDA2LTQ5NzEgKFByaW50

KSYjeEQ7MDAwNi00OTcxIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMjM5MzQyNTwv

YWNjZXNzaW9uLW51bT48d29yay10eXBlPkNvbXBhcmF0aXZlIFN0dWR5JiN4RDtSZXNlYXJjaCBT

dXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0JiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBVLlMuIEdv

diZhcG9zO3QsIFAuSC5TLjwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRw

Oi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzEyMzkzNDI1PC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTgyL2Jsb29kLTIwMDItMDUt

MTQ5NjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9y

ZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb250b3lpYW5uaXM8L0F1dGhvcj48WWVhcj4yMDEwPC9Z

ZWFyPjxSZWNOdW0+MTc5NTE8L1JlY051bT48RGlzcGxheVRleHQ+WzMwLTMyXTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xNzk1MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+

MTc5NTE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl

Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPktvbnRveWlhbm5p

cywgRC4gUC48L2F1dGhvcj48YXV0aG9yPk1hcnIsIEsuIEEuPC9hdXRob3I+PGF1dGhvcj5QYXJr

LCBCLiBKLjwvYXV0aG9yPjxhdXRob3I+QWxleGFuZGVyLCBCLiBELjwvYXV0aG9yPjxhdXRob3I+

QW5haXNzaWUsIEUuIEouPC9hdXRob3I+PGF1dGhvcj5XYWxzaCwgVC4gSi48L2F1dGhvcj48YXV0

aG9yPkl0bywgSi48L2F1dGhvcj48YXV0aG9yPkFuZGVzLCBELiBSLjwvYXV0aG9yPjxhdXRob3I+

QmFkZGxleSwgSi4gVy48L2F1dGhvcj48YXV0aG9yPkJyb3duLCBKLiBNLjwvYXV0aG9yPjxhdXRo

b3I+QnJ1bWJsZSwgTC4gTS48L2F1dGhvcj48YXV0aG9yPkZyZWlmZWxkLCBBLiBHLjwvYXV0aG9y

PjxhdXRob3I+SGFkbGV5LCBTLjwvYXV0aG9yPjxhdXRob3I+SGVyd2FsZHQsIEwuIEEuPC9hdXRo

b3I+PGF1dGhvcj5LYXVmZm1hbiwgQy4gQS48L2F1dGhvcj48YXV0aG9yPktuYXBwLCBLLjwvYXV0

aG9yPjxhdXRob3I+THlvbiwgRy4gTS48L2F1dGhvcj48YXV0aG9yPk1vcnJpc29uLCBWLiBBLjwv

YXV0aG9yPjxhdXRob3I+UGFwYW5pY29sYW91LCBHLjwvYXV0aG9yPjxhdXRob3I+UGF0dGVyc29u

LCBULiBGLjwvYXV0aG9yPjxhdXRob3I+UGVybCwgVC4gTS48L2F1dGhvcj48YXV0aG9yPlNjaHVz

dGVyLCBNLiBHLjwvYXV0aG9yPjxhdXRob3I+V2Fsa2VyLCBSLjwvYXV0aG9yPjxhdXRob3I+V2Fu

bmVtdWVobGVyLCBLLiBBLjwvYXV0aG9yPjxhdXRob3I+V2luZ2FyZCwgSi4gUi48L2F1dGhvcj48

YXV0aG9yPkNoaWxsZXIsIFQuIE0uPC9hdXRob3I+PGF1dGhvcj5QYXBwYXMsIFAuIEcuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VGhlIFVuaXZlcnNpdHkg

b2YgVGV4YXMgTUQgQW5kZXJzb24gQ2FuY2VyIENlbnRlciwgSG91c3RvbiwgVGV4YXMsIFVTQS4g

ZGtvbnRveWlAbWRhbmRlcnNvbi5vcmc8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Qcm9z

cGVjdGl2ZSBzdXJ2ZWlsbGFuY2UgZm9yIGludmFzaXZlIGZ1bmdhbCBpbmZlY3Rpb25zIGluIGhl

bWF0b3BvaWV0aWMgc3RlbSBjZWxsIHRyYW5zcGxhbnQgcmVjaXBpZW50cywgMjAwMS0yMDA2OiBv

dmVydmlldyBvZiB0aGUgVHJhbnNwbGFudC1Bc3NvY2lhdGVkIEluZmVjdGlvbiBTdXJ2ZWlsbGFu

Y2UgTmV0d29yayAoVFJBTlNORVQpIERhdGFiYXNlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNs

aW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwgaW5mZWN0

aW91cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZlY3Rpb3Vz

IERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPkNsaW4gSW5mZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+

PHBhZ2VzPjEwOTEtMTAwPC9wYWdlcz48dm9sdW1lPjUwPC92b2x1bWU+PG51bWJlcj44PC9udW1i

ZXI+PGVkaXRpb24+MjAxMC8wMy8xMjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVz

Y2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkLCBQcmVzY2hvb2w8L2tl

eXdvcmQ+PGtleXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9r

ZXl3b3JkPjxrZXl3b3JkPkhlbWF0b3BvaWV0aWMgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbi8q

YWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29y

ZD4qSW1tdW5vY29tcHJvbWlzZWQgSG9zdDwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8L2tl

eXdvcmQ+PGtleXdvcmQ+SW5mYW50PC9rZXl3b3JkPjxrZXl3b3JkPkluZmVjdGlvbiBDb250cm9s

Lypvcmdhbml6YXRpb24gJmFtcDsgYWRtaW5pc3RyYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+TWFs

ZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5NeWNvc2Vz

LyplcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5

d29yZD48a2V5d29yZD4qU2VudGluZWwgU3VydmVpbGxhbmNlPC9rZXl3b3JkPjxrZXl3b3JkPlVu

aXRlZCBTdGF0ZXMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPllvdW5nIEFkdWx0PC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5BcHIgMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0

cm9uaWMpJiN4RDsxMDU4LTQ4MzggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMjE4

ODc3PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgVS5TLiBHb3Ym

YXBvczt0LCBQLkguUy48L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMDIxODg3NzwvdXJsPjwvcmVsYXRlZC11cmxz

PjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA4Ni82NTEyNjM8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48

Q2l0ZT48QXV0aG9yPkphbnR1bmVuPC9BdXRob3I+PFllYXI+MTk5NzwvWWVhcj48UmVjTnVtPjI2

MTg0PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yNjE4NDwvcmVjLW51bWJlcj48Zm9yZWln

bi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcy

ZHh6cHRlcCI+MjYxODQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkph

bnR1bmVuLCBFLjwvYXV0aG9yPjxhdXRob3I+UnV1dHUsIFAuPC9hdXRob3I+PGF1dGhvcj5OaXNr

YW5lbiwgTC48L2F1dGhvcj48YXV0aG9yPlZvbGluLCBMLjwvYXV0aG9yPjxhdXRob3I+UGFya2th

bGksIFQuPC9hdXRob3I+PGF1dGhvcj5Lb3VraWxhLUthaGtvbGEsIFAuPC9hdXRob3I+PGF1dGhv

cj5SdXV0dSwgVC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5EZXBhcnRtZW50IG9mIE1lZGljaW5lLCBIZWxzaW5raSBVbml2ZXJzaXR5IENlbnRyYWwgSG9z

cGl0YWwsIEZpbmxhbmQuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+SW5jaWRlbmNlIGFu

ZCByaXNrIGZhY3RvcnMgZm9yIGludmFzaXZlIGZ1bmdhbCBpbmZlY3Rpb25zIGluIGFsbG9nZW5l

aWMgQk1UIHJlY2lwaWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qm9uZSBNYXJyb3cgVHJh

bnNwbGFudDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Qm9uZSBtYXJyb3cgdHJhbnNwbGFu

dGF0aW9uPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Qm9uZSBN

YXJyb3cgVHJhbnNwbGFudDwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjgwMS04PC9w

YWdlcz48dm9sdW1lPjE5PC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PGVkaXRpb24+MTk5Ny8w

NC8wMTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWN1dGUgRGlzZWFzZTwva2V5d29yZD48

a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3

b3JkPkFzcGVyZ2lsbG9zaXMvZXBpZGVtaW9sb2d5L2V0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3Jk

PkJvbmUgTWFycm93IFRyYW5zcGxhbnRhdGlvbi8qYWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxr

ZXl3b3JkPkNocm9uaWMgRGlzZWFzZTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+

PGtleXdvcmQ+R3JhZnQgdnMgSG9zdCBEaXNlYXNlL2NvbXBsaWNhdGlvbnMvZHJ1ZyB0aGVyYXB5

L2V0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkhlbWF0b2xvZ2ljIERpc2Vhc2VzL3RoZXJhcHk8

L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub3N1cHByZXNz

aXZlIEFnZW50cy9hZHZlcnNlIGVmZmVjdHMvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3

b3JkPkxldWtlbWlhL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5

d29yZD5NZXRoeWxwcmVkbmlzb2xvbmUvYWR2ZXJzZSBlZmZlY3RzL3RoZXJhcGV1dGljIHVzZTwv

a2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5NeWNvc2VzL2Vw

aWRlbWlvbG9neS8qZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVk

aWVzPC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5UaXNz

dWUgRG9ub3JzPC9rZXl3b3JkPjxrZXl3b3JkPlRyYW5zcGxhbnRhdGlvbiwgSG9tb2xvZ291czwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk3PC95ZWFyPjxwdWItZGF0ZXM+PGRh

dGU+QXByPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDI2OC0zMzY5IChQcmludCkm

I3hEOzAyNjgtMzM2OSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+OTEzNDE3MjwvYWNj

ZXNzaW9uLW51bT48d29yay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9z

O3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5s

bS5uaWguZ292L3B1Ym1lZC85MTM0MTcyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVj

dHJvbmljLXJlc291cmNlLW51bT4xMC4xMDM4L3NqLmJtdC4xNzAwNzM3PC9lbGVjdHJvbmljLXJl

c291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+

PEF1dGhvcj5NYXJyPC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48UmVjTnVtPjI2MTkwPC9SZWNO

dW0+PHJlY29yZD48cmVjLW51bWJlcj4yNjE5MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+

MjYxOTA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl

Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1hcnIsIEsuIEEu

PC9hdXRob3I+PGF1dGhvcj5DYXJ0ZXIsIFIuIEEuPC9hdXRob3I+PGF1dGhvcj5Cb2Vja2gsIE0u

PC9hdXRob3I+PGF1dGhvcj5NYXJ0aW4sIFAuPC9hdXRob3I+PGF1dGhvcj5Db3JleSwgTC48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5GcmVkIEh1dGNoaW5z

b24gQ2FuY2VyIFJlc2VhcmNoIENlbnRlciBQcm9ncmFtcyBpbiBJbmZlY3Rpb3VzIERpc2Vhc2Vz

IGFuZCBMb25nLXRlcm0gRm9sbG93LXVwLCBTZWF0dGxlLCBXQSA5ODEwOSwgVVNBLiBrbWFyckBm

aGNyYy5vcmc8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnZhc2l2ZSBhc3BlcmdpbGxv

c2lzIGluIGFsbG9nZW5laWMgc3RlbSBjZWxsIHRyYW5zcGxhbnQgcmVjaXBpZW50czogY2hhbmdl

cyBpbiBlcGlkZW1pb2xvZ3kgYW5kIHJpc2sgZmFjdG9yczwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5CbG9vZDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Qmxvb2Q8L2FsdC10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CbG9vZDwvZnVsbC10aXRsZT48L3BlcmlvZGlj

YWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJsb29kPC9mdWxsLXRpdGxlPjwvYWx0LXBl

cmlvZGljYWw+PHBhZ2VzPjQzNTgtNjY8L3BhZ2VzPjx2b2x1bWU+MTAwPC92b2x1bWU+PG51bWJl

cj4xMzwvbnVtYmVyPjxlZGl0aW9uPjIwMDIvMTAvMjQ8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3

b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWRyZW5hbCBDb3J0ZXggSG9ybW9uZXMv

YWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkFnZSBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QXNw

ZXJnaWxsb3Npcy8qZXBpZGVtaW9sb2d5L2V0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkJvbmUg

TWFycm93IFRyYW5zcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+

Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29y

ZD5Db2hvcnQgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5DeXRvbWVnYWxvdmlydXMgSW5mZWN0

aW9ucy9lcGlkZW1pb2xvZ3kvZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3

b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkdyYWZ0IHZz

IEhvc3QgRGlzZWFzZS9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvbG9naWMg

TmVvcGxhc21zL2NvbXBsaWNhdGlvbnMvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+KkhlbWF0

b3BvaWV0aWMgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVjdHM8L2tleXdv

cmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub3N1cHByZXNzaW9uL2Fk

dmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5JbW11bm9zdXBwcmVzc2l2ZSBBZ2VudHMv

YWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkluY2lkZW5jZTwva2V5d29yZD48a2V5

d29yZD5JbmZhbnQ8L2tleXdvcmQ+PGtleXdvcmQ+TGlmZSBUYWJsZXM8L2tleXdvcmQ+PGtleXdv

cmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5O

ZXV0cm9wZW5pYS9jaGVtaWNhbGx5IGluZHVjZWQvY29tcGxpY2F0aW9uczwva2V5d29yZD48a2V5

d29yZD5QZXJpcGhlcmFsIEJsb29kIFN0ZW0gQ2VsbCBUcmFuc3BsYW50YXRpb24vYWR2ZXJzZSBl

ZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IFRyYWN0IEluZmVjdGlvbnMvZXBp

ZGVtaW9sb2d5L2V0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29y

ZD48a2V5d29yZD5TdXJ2aXZhbCBBbmFseXNpczwva2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3Rv

cnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJhbnNwbGFudGF0aW9uIENvbmRpdGlvbmluZy9hZHZlcnNl

IGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+VHJhbnNwbGFudGF0aW9uLCBIb21vbG9nb3VzPC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5EZWMgMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDA2LTQ5NzEgKFByaW50

KSYjeEQ7MDAwNi00OTcxIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMjM5MzQyNTwv

YWNjZXNzaW9uLW51bT48d29yay10eXBlPkNvbXBhcmF0aXZlIFN0dWR5JiN4RDtSZXNlYXJjaCBT

dXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0JiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBVLlMuIEdv

diZhcG9zO3QsIFAuSC5TLjwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRw

Oi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzEyMzkzNDI1PC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTgyL2Jsb29kLTIwMDItMDUt

MTQ5NjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9y

ZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA [30-32]. T cell-depleted or CD34-selected stem cell products can also increase the risk of invasive aspergillosis PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJyPC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48UmVj

TnVtPjI2MTkwPC9SZWNOdW0+PERpc3BsYXlUZXh0PlszMiwgMzNdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjI2MTkwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNjE5MDwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFyciwgSy4gQS48L2F1dGhv

cj48YXV0aG9yPkNhcnRlciwgUi4gQS48L2F1dGhvcj48YXV0aG9yPkJvZWNraCwgTS48L2F1dGhv

cj48YXV0aG9yPk1hcnRpbiwgUC48L2F1dGhvcj48YXV0aG9yPkNvcmV5LCBMLjwvYXV0aG9yPjwv

YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkZyZWQgSHV0Y2hpbnNvbiBDYW5j

ZXIgUmVzZWFyY2ggQ2VudGVyIFByb2dyYW1zIGluIEluZmVjdGlvdXMgRGlzZWFzZXMgYW5kIExv

bmctdGVybSBGb2xsb3ctdXAsIFNlYXR0bGUsIFdBIDk4MTA5LCBVU0EuIGttYXJyQGZoY3JjLm9y

ZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkludmFzaXZlIGFzcGVyZ2lsbG9zaXMgaW4g

YWxsb2dlbmVpYyBzdGVtIGNlbGwgdHJhbnNwbGFudCByZWNpcGllbnRzOiBjaGFuZ2VzIGluIGVw

aWRlbWlvbG9neSBhbmQgcmlzayBmYWN0b3JzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJsb29k

PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5CbG9vZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJsb29kPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48YWx0

LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Qmxvb2Q8L2Z1bGwtdGl0bGU+PC9hbHQtcGVyaW9kaWNh

bD48cGFnZXM+NDM1OC02NjwvcGFnZXM+PHZvbHVtZT4xMDA8L3ZvbHVtZT48bnVtYmVyPjEzPC9u

dW1iZXI+PGVkaXRpb24+MjAwMi8xMC8yNDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWRv

bGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHJlbmFsIENvcnRleCBIb3Jtb25lcy9hZHZlcnNl

IGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlIEZh

Y3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxv

c2lzLyplcGlkZW1pb2xvZ3kvZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Qm9uZSBNYXJyb3cg

VHJhbnNwbGFudGF0aW9uL2FkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5DaGlsZDwv

a2V5d29yZD48a2V5d29yZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3b3JkPjxrZXl3b3JkPkNvaG9y

dCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkN5dG9tZWdhbG92aXJ1cyBJbmZlY3Rpb25zL2Vw

aWRlbWlvbG9neS9ldGlvbG9neTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtl

eXdvcmQ+Rm9sbG93LVVwIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+R3JhZnQgdnMgSG9zdCBE

aXNlYXNlL2VwaWRlbWlvbG9neTwva2V5d29yZD48a2V5d29yZD5IZW1hdG9sb2dpYyBOZW9wbGFz

bXMvY29tcGxpY2F0aW9ucy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD4qSGVtYXRvcG9pZXRp

YyBTdGVtIENlbGwgVHJhbnNwbGFudGF0aW9uL2FkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5

d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vc3VwcHJlc3Npb24vYWR2ZXJzZSBl

ZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub3N1cHByZXNzaXZlIEFnZW50cy9hZHZlcnNl

IGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+SW5jaWRlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPklu

ZmFudDwva2V5d29yZD48a2V5d29yZD5MaWZlIFRhYmxlczwva2V5d29yZD48a2V5d29yZD5NYWxl

PC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk5ldXRyb3Bl

bmlhL2NoZW1pY2FsbHkgaW5kdWNlZC9jb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPlBl

cmlwaGVyYWwgQmxvb2QgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVjdHM8

L2tleXdvcmQ+PGtleXdvcmQ+UmVzcGlyYXRvcnkgVHJhY3QgSW5mZWN0aW9ucy9lcGlkZW1pb2xv

Z3kvZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UmlzayBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3

b3JkPlN1cnZpdmFsIEFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5

d29yZD48a2V5d29yZD5UcmFuc3BsYW50YXRpb24gQ29uZGl0aW9uaW5nL2FkdmVyc2UgZWZmZWN0

czwva2V5d29yZD48a2V5d29yZD5UcmFuc3BsYW50YXRpb24sIEhvbW9sb2dvdXM8L2tleXdvcmQ+

PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRlYyAx

NTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMDYtNDk3MSAoUHJpbnQpJiN4RDsw

MDA2LTQ5NzEgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEyMzkzNDI1PC9hY2Nlc3Np

b24tbnVtPjx3b3JrLXR5cGU+Q29tcGFyYXRpdmUgU3R1ZHkmI3hEO1Jlc2VhcmNoIFN1cHBvcnQs

IE5vbi1VLlMuIEdvdiZhcG9zO3QmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIFUuUy4gR292JmFwb3M7

dCwgUC5ILlMuPC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTIzOTM0MjU8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy

bHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExODIvYmxvb2QtMjAwMi0wNS0xNDk2PC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48

L0NpdGU+PENpdGU+PEF1dGhvcj52YW4gQnVyaWs8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS

ZWNOdW0+MjYxNjU8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI2MTY1PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0

ZjloOTBwdzJkeHpwdGVwIj4yNjE2NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l

PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh

dXRob3I+dmFuIEJ1cmlrLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+Q2FydGVyLCBTLiBMLjwvYXV0

aG9yPjxhdXRob3I+RnJlaWZlbGQsIEEuIEcuPC9hdXRob3I+PGF1dGhvcj5IaWdoLCBLLiBQLjwv

YXV0aG9yPjxhdXRob3I+R29kZGVyLCBLLiBULjwvYXV0aG9yPjxhdXRob3I+UGFwYW5pY29sYW91

LCBHLiBBLjwvYXV0aG9yPjxhdXRob3I+TWVuZGl6YWJhbCwgQS4gTS48L2F1dGhvcj48YXV0aG9y

PldhZ25lciwgSi4gRS48L2F1dGhvcj48YXV0aG9yPllhbm92aWNoLCBTLjwvYXV0aG9yPjxhdXRo

b3I+S2VybmFuLCBOLiBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1h

ZGRyZXNzPkRlcGFydG1lbnQgb2YgUGVkaWF0cmljcyBhbmQgTWVkaWNpbmUsIFVuaXZlcnNpdHkg

b2YgTWlubmVzb3RhLCBNaW5uZWFwb2xpcywgTWlubmVzb3RhLCBVU0EuIHZhbmJ1MDA0QHVtbi5l

ZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5IaWdoZXIgcmlzayBvZiBjeXRvbWVnYWxv

dmlydXMgYW5kIGFzcGVyZ2lsbHVzIGluZmVjdGlvbnMgaW4gcmVjaXBpZW50cyBvZiBUIGNlbGwt

ZGVwbGV0ZWQgdW5yZWxhdGVkIGJvbmUgbWFycm93OiBhbmFseXNpcyBvZiBpbmZlY3Rpb3VzIGNv

bXBsaWNhdGlvbnMgaW4gcGF0aWVudHMgdHJlYXRlZCB3aXRoIFQgY2VsbCBkZXBsZXRpb24gdmVy

c3VzIGltbXVub3N1cHByZXNzaXZlIHRoZXJhcHkgdG8gcHJldmVudCBncmFmdC12ZXJzdXMtaG9z

dCBkaXNlYXNlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJpb2wgQmxvb2QgTWFycm93IFRyYW5z

cGxhbnQ8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkJpb2xvZ3kgb2YgYmxvb2QgYW5kIG1h

cnJvdyB0cmFuc3BsYW50YXRpb24gOiBqb3VybmFsIG9mIHRoZSBBbWVyaWNhbiBTb2NpZXR5IGZv

ciBCbG9vZCBhbmQgTWFycm93IFRyYW5zcGxhbnRhdGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJpb2wgQmxvb2QgTWFycm93IFRyYW5zcGxhbnQ8L2Z1bGwt

dGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4xNDg3LTk4PC9wYWdlcz48dm9sdW1lPjEzPC92b2x1

bWU+PG51bWJlcj4xMjwvbnVtYmVyPjxlZGl0aW9uPjIwMDcvMTEvMjE8L2VkaXRpb24+PGtleXdv

cmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+

PGtleXdvcmQ+KkFzcGVyZ2lsbG9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+KkJvbmUgTWFycm93IFRy

YW5zcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVjdHMvbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5D

b2hvcnQgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5DeWNsb3Nwb3JpbmUvdGhlcmFwZXV0aWMg

dXNlPC9rZXl3b3JkPjxrZXl3b3JkPkN5dG9tZWdhbG92aXJ1cyBJbmZlY3Rpb25zLyplcGlkZW1p

b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkdyYWZ0IHZz

IEhvc3QgRGlzZWFzZS9jb21wbGljYXRpb25zL3ByZXZlbnRpb24gJmFtcDsgY29udHJvbDwva2V5

d29yZD48a2V5d29yZD4qSGVtYXRvcG9pZXRpYyBTdGVtIENlbGwgVHJhbnNwbGFudGF0aW9uL2Fk

dmVyc2UgZWZmZWN0cy9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48

a2V5d29yZD5JbW11bm9zdXBwcmVzc2lvbi9hZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdv

cmQ+SW1tdW5vc3VwcHJlc3NpdmUgQWdlbnRzL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5

d29yZD5JbmNpZGVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+THltcGhvY3l0ZSBEZXBsZXRpb24vKmFk

dmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1l

dGhvdHJleGF0ZS90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+T3Bwb3J0dW5pc3Rp

YyBJbmZlY3Rpb25zLyplcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2

ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlN1cnZpdmFsIEFuYWx5c2lzPC9rZXl3b3JkPjxr

ZXl3b3JkPlRyYW5zcGxhbnRhdGlvbiwgSG9tb2xvZ291cy9hZHZlcnNlIGVmZmVjdHM8L2tleXdv

cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRl

YzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwODMtODc5MSAoUHJpbnQpJiN4RDsx

MDgzLTg3OTEgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE4MDIyNTc5PC9hY2Nlc3Np

b24tbnVtPjx3b3JrLXR5cGU+TXVsdGljZW50ZXIgU3R1ZHkmI3hEO1JhbmRvbWl6ZWQgQ29udHJv

bGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRyYW11cmFsPC93b3Jr

LXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMTgwMjI1Nzk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPjEwLjEwMTYvai5iYm10LjIwMDcuMDguMDQ5PC9lbGVjdHJvbmljLXJlc291

cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3Rl

Pn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJyPC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48UmVj

TnVtPjI2MTkwPC9SZWNOdW0+PERpc3BsYXlUZXh0PlszMiwgMzNdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjI2MTkwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNjE5MDwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFyciwgSy4gQS48L2F1dGhv

cj48YXV0aG9yPkNhcnRlciwgUi4gQS48L2F1dGhvcj48YXV0aG9yPkJvZWNraCwgTS48L2F1dGhv

cj48YXV0aG9yPk1hcnRpbiwgUC48L2F1dGhvcj48YXV0aG9yPkNvcmV5LCBMLjwvYXV0aG9yPjwv

YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkZyZWQgSHV0Y2hpbnNvbiBDYW5j

ZXIgUmVzZWFyY2ggQ2VudGVyIFByb2dyYW1zIGluIEluZmVjdGlvdXMgRGlzZWFzZXMgYW5kIExv

bmctdGVybSBGb2xsb3ctdXAsIFNlYXR0bGUsIFdBIDk4MTA5LCBVU0EuIGttYXJyQGZoY3JjLm9y

ZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkludmFzaXZlIGFzcGVyZ2lsbG9zaXMgaW4g

YWxsb2dlbmVpYyBzdGVtIGNlbGwgdHJhbnNwbGFudCByZWNpcGllbnRzOiBjaGFuZ2VzIGluIGVw

aWRlbWlvbG9neSBhbmQgcmlzayBmYWN0b3JzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJsb29k

PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5CbG9vZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJsb29kPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48YWx0

LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Qmxvb2Q8L2Z1bGwtdGl0bGU+PC9hbHQtcGVyaW9kaWNh

bD48cGFnZXM+NDM1OC02NjwvcGFnZXM+PHZvbHVtZT4xMDA8L3ZvbHVtZT48bnVtYmVyPjEzPC9u

dW1iZXI+PGVkaXRpb24+MjAwMi8xMC8yNDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWRv

bGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHJlbmFsIENvcnRleCBIb3Jtb25lcy9hZHZlcnNl

IGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlIEZh

Y3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxv

c2lzLyplcGlkZW1pb2xvZ3kvZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Qm9uZSBNYXJyb3cg

VHJhbnNwbGFudGF0aW9uL2FkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5DaGlsZDwv

a2V5d29yZD48a2V5d29yZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3b3JkPjxrZXl3b3JkPkNvaG9y

dCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkN5dG9tZWdhbG92aXJ1cyBJbmZlY3Rpb25zL2Vw

aWRlbWlvbG9neS9ldGlvbG9neTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtl

eXdvcmQ+Rm9sbG93LVVwIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+R3JhZnQgdnMgSG9zdCBE

aXNlYXNlL2VwaWRlbWlvbG9neTwva2V5d29yZD48a2V5d29yZD5IZW1hdG9sb2dpYyBOZW9wbGFz

bXMvY29tcGxpY2F0aW9ucy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD4qSGVtYXRvcG9pZXRp

YyBTdGVtIENlbGwgVHJhbnNwbGFudGF0aW9uL2FkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5

d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vc3VwcHJlc3Npb24vYWR2ZXJzZSBl

ZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub3N1cHByZXNzaXZlIEFnZW50cy9hZHZlcnNl

IGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+SW5jaWRlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPklu

ZmFudDwva2V5d29yZD48a2V5d29yZD5MaWZlIFRhYmxlczwva2V5d29yZD48a2V5d29yZD5NYWxl

PC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk5ldXRyb3Bl

bmlhL2NoZW1pY2FsbHkgaW5kdWNlZC9jb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPlBl

cmlwaGVyYWwgQmxvb2QgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVjdHM8

L2tleXdvcmQ+PGtleXdvcmQ+UmVzcGlyYXRvcnkgVHJhY3QgSW5mZWN0aW9ucy9lcGlkZW1pb2xv

Z3kvZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UmlzayBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3

b3JkPlN1cnZpdmFsIEFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5

d29yZD48a2V5d29yZD5UcmFuc3BsYW50YXRpb24gQ29uZGl0aW9uaW5nL2FkdmVyc2UgZWZmZWN0

czwva2V5d29yZD48a2V5d29yZD5UcmFuc3BsYW50YXRpb24sIEhvbW9sb2dvdXM8L2tleXdvcmQ+

PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRlYyAx

NTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMDYtNDk3MSAoUHJpbnQpJiN4RDsw

MDA2LTQ5NzEgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEyMzkzNDI1PC9hY2Nlc3Np

b24tbnVtPjx3b3JrLXR5cGU+Q29tcGFyYXRpdmUgU3R1ZHkmI3hEO1Jlc2VhcmNoIFN1cHBvcnQs

IE5vbi1VLlMuIEdvdiZhcG9zO3QmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIFUuUy4gR292JmFwb3M7

dCwgUC5ILlMuPC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTIzOTM0MjU8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy

bHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExODIvYmxvb2QtMjAwMi0wNS0xNDk2PC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48

L0NpdGU+PENpdGU+PEF1dGhvcj52YW4gQnVyaWs8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS

ZWNOdW0+MjYxNjU8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI2MTY1PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0

ZjloOTBwdzJkeHpwdGVwIj4yNjE2NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l

PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh

dXRob3I+dmFuIEJ1cmlrLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+Q2FydGVyLCBTLiBMLjwvYXV0

aG9yPjxhdXRob3I+RnJlaWZlbGQsIEEuIEcuPC9hdXRob3I+PGF1dGhvcj5IaWdoLCBLLiBQLjwv

YXV0aG9yPjxhdXRob3I+R29kZGVyLCBLLiBULjwvYXV0aG9yPjxhdXRob3I+UGFwYW5pY29sYW91

LCBHLiBBLjwvYXV0aG9yPjxhdXRob3I+TWVuZGl6YWJhbCwgQS4gTS48L2F1dGhvcj48YXV0aG9y

PldhZ25lciwgSi4gRS48L2F1dGhvcj48YXV0aG9yPllhbm92aWNoLCBTLjwvYXV0aG9yPjxhdXRo

b3I+S2VybmFuLCBOLiBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1h

ZGRyZXNzPkRlcGFydG1lbnQgb2YgUGVkaWF0cmljcyBhbmQgTWVkaWNpbmUsIFVuaXZlcnNpdHkg

b2YgTWlubmVzb3RhLCBNaW5uZWFwb2xpcywgTWlubmVzb3RhLCBVU0EuIHZhbmJ1MDA0QHVtbi5l

ZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5IaWdoZXIgcmlzayBvZiBjeXRvbWVnYWxv

dmlydXMgYW5kIGFzcGVyZ2lsbHVzIGluZmVjdGlvbnMgaW4gcmVjaXBpZW50cyBvZiBUIGNlbGwt

ZGVwbGV0ZWQgdW5yZWxhdGVkIGJvbmUgbWFycm93OiBhbmFseXNpcyBvZiBpbmZlY3Rpb3VzIGNv

bXBsaWNhdGlvbnMgaW4gcGF0aWVudHMgdHJlYXRlZCB3aXRoIFQgY2VsbCBkZXBsZXRpb24gdmVy

c3VzIGltbXVub3N1cHByZXNzaXZlIHRoZXJhcHkgdG8gcHJldmVudCBncmFmdC12ZXJzdXMtaG9z

dCBkaXNlYXNlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJpb2wgQmxvb2QgTWFycm93IFRyYW5z

cGxhbnQ8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkJpb2xvZ3kgb2YgYmxvb2QgYW5kIG1h

cnJvdyB0cmFuc3BsYW50YXRpb24gOiBqb3VybmFsIG9mIHRoZSBBbWVyaWNhbiBTb2NpZXR5IGZv

ciBCbG9vZCBhbmQgTWFycm93IFRyYW5zcGxhbnRhdGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJpb2wgQmxvb2QgTWFycm93IFRyYW5zcGxhbnQ8L2Z1bGwt

dGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4xNDg3LTk4PC9wYWdlcz48dm9sdW1lPjEzPC92b2x1

bWU+PG51bWJlcj4xMjwvbnVtYmVyPjxlZGl0aW9uPjIwMDcvMTEvMjE8L2VkaXRpb24+PGtleXdv

cmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+

PGtleXdvcmQ+KkFzcGVyZ2lsbG9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+KkJvbmUgTWFycm93IFRy

YW5zcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVjdHMvbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5D

b2hvcnQgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5DeWNsb3Nwb3JpbmUvdGhlcmFwZXV0aWMg

dXNlPC9rZXl3b3JkPjxrZXl3b3JkPkN5dG9tZWdhbG92aXJ1cyBJbmZlY3Rpb25zLyplcGlkZW1p

b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkdyYWZ0IHZz

IEhvc3QgRGlzZWFzZS9jb21wbGljYXRpb25zL3ByZXZlbnRpb24gJmFtcDsgY29udHJvbDwva2V5

d29yZD48a2V5d29yZD4qSGVtYXRvcG9pZXRpYyBTdGVtIENlbGwgVHJhbnNwbGFudGF0aW9uL2Fk

dmVyc2UgZWZmZWN0cy9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48

a2V5d29yZD5JbW11bm9zdXBwcmVzc2lvbi9hZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdv

cmQ+SW1tdW5vc3VwcHJlc3NpdmUgQWdlbnRzL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5

d29yZD5JbmNpZGVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+THltcGhvY3l0ZSBEZXBsZXRpb24vKmFk

dmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1l

dGhvdHJleGF0ZS90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+T3Bwb3J0dW5pc3Rp

YyBJbmZlY3Rpb25zLyplcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2

ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlN1cnZpdmFsIEFuYWx5c2lzPC9rZXl3b3JkPjxr

ZXl3b3JkPlRyYW5zcGxhbnRhdGlvbiwgSG9tb2xvZ291cy9hZHZlcnNlIGVmZmVjdHM8L2tleXdv

cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRl

YzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwODMtODc5MSAoUHJpbnQpJiN4RDsx

MDgzLTg3OTEgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE4MDIyNTc5PC9hY2Nlc3Np

b24tbnVtPjx3b3JrLXR5cGU+TXVsdGljZW50ZXIgU3R1ZHkmI3hEO1JhbmRvbWl6ZWQgQ29udHJv

bGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRyYW11cmFsPC93b3Jr

LXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMTgwMjI1Nzk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPjEwLjEwMTYvai5iYm10LjIwMDcuMDguMDQ5PC9lbGVjdHJvbmljLXJlc291

cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3Rl

Pn==

ADDIN EN.CITE.DATA [32, 33]. Among allogeneic HSCT recipients, polymorphisms in specific host defense genes of the donor or recipient can also influence the risk of aspergillosis PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb2NodWQ8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+MjYyNjg8L1JlY051bT48RGlzcGxheVRleHQ+WzM0LTM3XTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4yNjI2ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+MjYyNjg8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJvY2h1ZCwgUC4gWS48L2F1

dGhvcj48YXV0aG9yPkNoaWVuLCBKLiBXLjwvYXV0aG9yPjxhdXRob3I+TWFyciwgSy4gQS48L2F1

dGhvcj48YXV0aG9yPkxlaXNlbnJpbmcsIFcuIE0uPC9hdXRob3I+PGF1dGhvcj5VcHRvbiwgQS48

L2F1dGhvcj48YXV0aG9yPkphbmVyLCBNLjwvYXV0aG9yPjxhdXRob3I+Um9kcmlndWVzLCBTLiBE

LjwvYXV0aG9yPjxhdXRob3I+TGksIFMuPC9hdXRob3I+PGF1dGhvcj5IYW5zZW4sIEouIEEuPC9h

dXRob3I+PGF1dGhvcj5aaGFvLCBMLiBQLjwvYXV0aG9yPjxhdXRob3I+QWRlcmVtLCBBLjwvYXV0

aG9yPjxhdXRob3I+Qm9lY2toLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

YXV0aC1hZGRyZXNzPkluc3RpdHV0ZSBmb3IgU3lzdGVtcyBCaW9sb2d5LCBGcmVkIEh1dGNoaW5z

b24gQ2FuY2VyIFJlc2VhcmNoIENlbnRlciwgU2VhdHRsZSwgV0EgOTgxMDksIFVTQS48L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Ub2xsLWxpa2UgcmVjZXB0b3IgNCBwb2x5bW9ycGhpc21z

IGFuZCBhc3BlcmdpbGxvc2lzIGluIHN0ZW0tY2VsbCB0cmFuc3BsYW50YXRpb248L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+TiBFbmdsIEogTWVkPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5U

aGUgTmV3IEVuZ2xhbmQgam91cm5hbCBvZiBtZWRpY2luZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk4gRW5nbCBKIE1lZDwvZnVsbC10aXRsZT48L3BlcmlvZGlj

YWw+PHBhZ2VzPjE3NjYtNzc8L3BhZ2VzPjx2b2x1bWU+MzU5PC92b2x1bWU+PG51bWJlcj4xNzwv

bnVtYmVyPjxlZGl0aW9uPjIwMDgvMTAvMjQ8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFk

dWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFuYWx5c2lzIG9mIFZhcmlhbmNlPC9rZXl3b3JkPjxrZXl3

b3JkPkFzcGVyZ2lsbG9zaXMvKmdlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVz

IGZ1bWlnYXR1czwva2V5d29yZD48a2V5d29yZD5DYXNlLUNvbnRyb2wgU3R1ZGllczwva2V5d29y

ZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+R2VuZXRpYyBQcmVkaXNwb3NpdGlv

biB0byBEaXNlYXNlPC9rZXl3b3JkPjxrZXl3b3JkPkhhcGxvdHlwZXM8L2tleXdvcmQ+PGtleXdv

cmQ+KkhlbWF0b3BvaWV0aWMgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVj

dHMvbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5J

bmNpZGVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+TGlua2FnZSBEaXNlcXVpbGlicml1bTwva2V5d29y

ZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxr

ZXl3b3JkPipQb2x5bW9ycGhpc20sIFNpbmdsZSBOdWNsZW90aWRlPC9rZXl3b3JkPjxrZXl3b3Jk

PlByb3BvcnRpb25hbCBIYXphcmRzIE1vZGVsczwva2V5d29yZD48a2V5d29yZD5SaXNrIEFzc2Vz

c21lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+VG9sbC1MaWtlIFJlY2VwdG9yIDQvKmdlbmV0aWNzPC9r

ZXl3b3JkPjxrZXl3b3JkPlRvbGwtTGlrZSBSZWNlcHRvcnMvZ2VuZXRpY3M8L2tleXdvcmQ+PGtl

eXdvcmQ+VHJhbnNwbGFudGF0aW9uLCBIb21vbG9nb3VzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMDg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5PY3QgMjM8L2RhdGU+PC9wdWIt

ZGF0ZXM+PC9kYXRlcz48aXNibj4xNTMzLTQ0MDYgKEVsZWN0cm9uaWMpJiN4RDswMDI4LTQ3OTMg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE4OTQ2MDYyPC9hY2Nlc3Npb24tbnVtPjx3

b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRyYW11cmFsJiN4RDtSZXNlYXJj

aCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0JiN4RDtWYWxpZGF0aW9uIFN0dWRpZXM8L3dv

cmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWgu

Z292L3B1Ym1lZC8xODk0NjA2MjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj4y

NjU2NjEwPC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDU2L05FSk1vYTA4

MDI2Mjk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlphYXM8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFy

PjxSZWNOdW0+MjYyODY8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI2Mjg2PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhy

bXh0ZjloOTBwdzJkeHpwdGVwIj4yNjI4Njwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBu

YW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3Jz

PjxhdXRob3I+WmFhcywgQS4gSy48L2F1dGhvcj48YXV0aG9yPkxpYW8sIEcuPC9hdXRob3I+PGF1

dGhvcj5DaGllbiwgSi4gVy48L2F1dGhvcj48YXV0aG9yPldlaW5iZXJnLCBDLjwvYXV0aG9yPjxh

dXRob3I+U2hvcmUsIEQuPC9hdXRob3I+PGF1dGhvcj5HaWxlcywgUy4gUy48L2F1dGhvcj48YXV0

aG9yPk1hcnIsIEsuIEEuPC9hdXRob3I+PGF1dGhvcj5Vc3VrYSwgSi48L2F1dGhvcj48YXV0aG9y

PkJ1cmNoLCBMLiBILjwvYXV0aG9yPjxhdXRob3I+UGVyZXJhLCBMLjwvYXV0aG9yPjxhdXRob3I+

UGVyZmVjdCwgSi4gUi48L2F1dGhvcj48YXV0aG9yPlBlbHR6LCBHLjwvYXV0aG9yPjxhdXRob3I+

U2Nod2FydHosIEQuIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFk

ZHJlc3M+RHVrZSBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBEdXJoYW0sIE5vcnRoIENhcm9s

aW5hLCBVbml0ZWQgU3RhdGVzIG9mIEFtZXJpY2EuIGFpbWVlLnphYXNAZHVrZS5lZHU8L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5QbGFzbWlub2dlbiBhbGxlbGVzIGluZmx1ZW5jZSBzdXNj

ZXB0aWJpbGl0eSB0byBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPlBMb1MgR2VuZXQ8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlBMb1MgZ2VuZXRpY3M8

L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QTG9TIEdlbmV0PC9m

dWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+ZTEwMDAxMDE8L3BhZ2VzPjx2b2x1bWU+NDwv

dm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxlZGl0aW9uPjIwMDgvMDYvMjE8L2VkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPipBbGxlbGVzPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdv

cmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qZ2VuZXRpY3MvKm1pY3JvYmlvbG9neS9tb3J0YWxp

dHkvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzIGZ1bWlnYXR1cy9pbW11

bm9sb2d5L3BhdGhvZ2VuaWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxr

ZXl3b3JkPipHZW5ldGljIFByZWRpc3Bvc2l0aW9uIHRvIERpc2Vhc2U8L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcgRGlzZWFzZXMsIEZ1bmdhbC8qZ2VuZXRp

Y3MvaW1tdW5vbG9neS8qbWljcm9iaW9sb2d5L21vcnRhbGl0eTwva2V5d29yZD48a2V5d29yZD5N

aWNlPC9rZXl3b3JkPjxrZXl3b3JkPk1pY2UsIEluYnJlZCBBPC9rZXl3b3JkPjxrZXl3b3JkPk1p

Y2UsIEluYnJlZCBBS1I8L2tleXdvcmQ+PGtleXdvcmQ+TWljZSwgSW5icmVkIEJBTEIgQzwva2V5

d29yZD48a2V5d29yZD5NaWNlLCBJbmJyZWQgQzNIPC9rZXl3b3JkPjxrZXl3b3JkPk1pY2UsIElu

YnJlZCBDNTdCTDwva2V5d29yZD48a2V5d29yZD5NaWNlLCBJbmJyZWQgREJBPC9rZXl3b3JkPjxr

ZXl3b3JkPk1pY2UsIEluYnJlZCBNUkwgbHByPC9rZXl3b3JkPjxrZXl3b3JkPk1pY2UsIEluYnJl

ZCBOWkI8L2tleXdvcmQ+PGtleXdvcmQ+TWljZSwgS25vY2tvdXQ8L2tleXdvcmQ+PGtleXdvcmQ+

UGxhc21pbm9nZW4vKmdlbmV0aWNzL3BoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+U2lnbmFs

IFRyYW5zZHVjdGlvbi8qZ2VuZXRpY3M8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAwODwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVz

Pjxpc2JuPjE1NTMtNzQwNCAoRWxlY3Ryb25pYykmI3hEOzE1NTMtNzM5MCAoTGlua2luZyk8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+MTg1NjY2NzI8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5Db21w

YXJhdGl2ZSBTdHVkeSYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRyYW11cmFsJiN4

RDtSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEludHJhbXVyYWw8L3dvcmstdHlwZT48dXJscz48

cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xODU2

NjY3MjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj4yNDIzNDg1PC9jdXN0b20y

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMzcxL2pvdXJuYWwucGdlbi4xMDAwMTAxPC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48

L0NpdGU+PENpdGU+PEF1dGhvcj5DdW5oYTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051

bT4yNjI5MjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjYyOTI8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5

MHB3MmR4enB0ZXAiPjI2MjkyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5DdW5oYSwgQy48L2F1dGhvcj48YXV0aG9yPkF2ZXJzYSwgRi48L2F1dGhvcj48YXV0aG9yPkxh

Y2VyZGEsIEouIEYuPC9hdXRob3I+PGF1dGhvcj5CdXNjYSwgQS48L2F1dGhvcj48YXV0aG9yPkt1

cnphaSwgTy48L2F1dGhvcj48YXV0aG9yPkdydWJlLCBNLjwvYXV0aG9yPjxhdXRob3I+TG9mZmxl

ciwgSi48L2F1dGhvcj48YXV0aG9yPk1hZXJ0ZW5zLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+QmVs

bCwgQS4gUy48L2F1dGhvcj48YXV0aG9yPkluZm9yemF0bywgQS48L2F1dGhvcj48YXV0aG9yPkJh

cmJhdGksIEUuPC9hdXRob3I+PGF1dGhvcj5BbG1laWRhLCBCLjwvYXV0aG9yPjxhdXRob3I+U2Fu

dG9zIGUgU291c2EsIFAuPC9hdXRob3I+PGF1dGhvcj5CYXJidWksIEEuPC9hdXRob3I+PGF1dGhv

cj5Qb3RlbnphLCBMLjwvYXV0aG9yPjxhdXRob3I+Q2FpcmEsIE0uPC9hdXRob3I+PGF1dGhvcj5S

b2RyaWd1ZXMsIEYuPC9hdXRob3I+PGF1dGhvcj5TYWx2YXRvcmksIEcuPC9hdXRob3I+PGF1dGhv

cj5QYWdhbm8sIEwuPC9hdXRob3I+PGF1dGhvcj5MdXBwaSwgTS48L2F1dGhvcj48YXV0aG9yPk1h

bnRvdmFuaSwgQS48L2F1dGhvcj48YXV0aG9yPlZlbGFyZGksIEEuPC9hdXRob3I+PGF1dGhvcj5S

b21hbmksIEwuPC9hdXRob3I+PGF1dGhvcj5DYXJ2YWxobywgQS48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5UaGUgYXV0aG9ycyZhcG9zOyBhZmZpbGlhdGlv

bnMgYXJlIGxpc3RlZCBpbiB0aGUgQXBwZW5kaXguPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0

bGU+R2VuZXRpYyBQVFgzIGRlZmljaWVuY3kgYW5kIGFzcGVyZ2lsbG9zaXMgaW4gc3RlbS1jZWxs

IHRyYW5zcGxhbnRhdGlvbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OIEVuZ2wgSiBNZWQ8L3Nl

Y29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlRoZSBOZXcgRW5nbGFuZCBqb3VybmFsIG9mIG1lZGlj

aW5lPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TiBFbmdsIEog

TWVkPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NDIxLTMyPC9wYWdlcz48dm9sdW1l

PjM3MDwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxlZGl0aW9uPjIwMTQvMDEvMzE8L2VkaXRp

b24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9z

aXMvKmdlbmV0aWNzL2ltbXVub2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Qy1SZWFjdGl2ZSBQcm90

ZWluLypkZWZpY2llbmN5L2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29y

ZD48a2V5d29yZD5HZW5ldGljIFByZWRpc3Bvc2l0aW9uIHRvIERpc2Vhc2U8L2tleXdvcmQ+PGtl

eXdvcmQ+SGFwbG90eXBlczwva2V5d29yZD48a2V5d29yZD4qSGVtYXRvcG9pZXRpYyBTdGVtIENl

bGwgVHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5

d29yZD5JbW11bml0eSwgSW5uYXRlLypnZW5ldGljczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9r

ZXl3b3JkPjxrZXl3b3JkPk5ldXRyb3BoaWxzLyppbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3Jk

PipQb2x5bW9ycGhpc20sIFNpbmdsZSBOdWNsZW90aWRlPC9rZXl3b3JkPjxrZXl3b3JkPlNlcnVt

IEFteWxvaWQgUC1Db21wb25lbnQvKmRlZmljaWVuY3kvZ2VuZXRpY3M8L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48cHViLWRhdGVzPjxkYXRlPkphbiAzMDwvZGF0

ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzMtNDQwNiAoRWxlY3Ryb25pYykmI3hEOzAw

MjgtNDc5MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjQ0NzY0MzI8L2FjY2Vzc2lv

bi1udW0+PHdvcmstdHlwZT5NdWx0aWNlbnRlciBTdHVkeSYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwg

Tm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o

dHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI0NDc2NDMyPC91cmw+PC9yZWxhdGVk

LXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDU2L05FSk1vYTEyMTEx

NjE8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVj

b3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkN1bmhhPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48

UmVjTnVtPjIyNDwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjI0PC9yZWMtbnVtYmVyPjxm

b3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBz

cHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9IjE0MTM4MzIzMjEiPjIyNDwva2V5PjwvZm9yZWlnbi1r

ZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJp

YnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Q3VuaGEsIEMuPC9hdXRob3I+PGF1dGhvcj5EaSBJYW5u

aSwgTS48L2F1dGhvcj48YXV0aG9yPkJvenphLCBTLjwvYXV0aG9yPjxhdXRob3I+R2lvdmFubmlu

aSwgRy48L2F1dGhvcj48YXV0aG9yPlphZ2FyZWxsYSwgUy48L2F1dGhvcj48YXV0aG9yPlplbGFu

dGUsIFQuPC9hdXRob3I+PGF1dGhvcj5EJmFwb3M7QW5nZWxvLCBDLjwvYXV0aG9yPjxhdXRob3I+

UGllcmluaSwgQS48L2F1dGhvcj48YXV0aG9yPlBpdHp1cnJhLCBMLjwvYXV0aG9yPjxhdXRob3I+

RmFsemV0dGksIEYuPC9hdXRob3I+PGF1dGhvcj5DYXJvdHRpLCBBLjwvYXV0aG9yPjxhdXRob3I+

UGVycnVjY2lvLCBLLjwvYXV0aG9yPjxhdXRob3I+TGF0Z2UsIEouIFAuPC9hdXRob3I+PGF1dGhv

cj5Sb2RyaWd1ZXMsIEYuPC9hdXRob3I+PGF1dGhvcj5WZWxhcmRpLCBBLjwvYXV0aG9yPjxhdXRo

b3I+QXZlcnNhLCBGLjwvYXV0aG9yPjxhdXRob3I+Um9tYW5pLCBMLjwvYXV0aG9yPjxhdXRob3I+

Q2FydmFsaG8sIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl

c3M+TWljcm9iaW9sb2d5IFNlY3Rpb24sIERlcGFydG1lbnQgb2YgRXhwZXJpbWVudGFsIE1lZGlj

aW5lIGFuZCBCaW9jaGVtaWNhbCBTY2llbmNlcywgVW5pdmVyc2l0eSBvZiBQZXJ1Z2lhLCBQZXJ1

Z2lhLCBJdGFseS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EZWN0aW4tMSBZMjM4WCBw

b2x5bW9ycGhpc20gYXNzb2NpYXRlcyB3aXRoIHN1c2NlcHRpYmlsaXR5IHRvIGludmFzaXZlIGFz

cGVyZ2lsbG9zaXMgaW4gaGVtYXRvcG9pZXRpYyB0cmFuc3BsYW50YXRpb24gdGhyb3VnaCBpbXBh

aXJtZW50IG9mIGJvdGggcmVjaXBpZW50LSBhbmQgZG9ub3ItZGVwZW5kZW50IG1lY2hhbmlzbXMg

b2YgYW50aWZ1bmdhbCBpbW11bml0eTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5CbG9vZDwvc2Vj

b25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Qmxvb2Q8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5CbG9vZDwvZnVsbC10aXRsZT48YWJici0xPkJsb29kPC9hYmJyLTE+

PGFiYnItMj5CbG9vZDwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+Qmxvb2Q8L2Z1bGwtdGl0bGU+PGFiYnItMT5CbG9vZDwvYWJici0xPjxhYmJyLTI+Qmxv

b2Q8L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz41Mzk0LTQwMjwvcGFnZXM+PHZvbHVt

ZT4xMTY8L3ZvbHVtZT48bnVtYmVyPjI0PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xl

c2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5

d29yZD48a2V5d29yZD5BbmltYWxzPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvKmV0

aW9sb2d5L2dlbmV0aWNzL2ltbXVub2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdv

cmQ+PGtleXdvcmQ+Q3l0b2tpbmVzL2Jpb3N5bnRoZXNpczwva2V5d29yZD48a2V5d29yZD5EaXNl

YXNlIFN1c2NlcHRpYmlsaXR5LypldGlvbG9neTwva2V5d29yZD48a2V5d29yZD5FcGl0aGVsaWFs

IENlbGxzL2ltbXVub2xvZ3kvbWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tl

eXdvcmQ+PGtleXdvcmQ+RnVuZ2kvaW1tdW5vbG9neTwva2V5d29yZD48a2V5d29yZD5IZW1hdG9w

b2lldGljIFN0ZW0gQ2VsbCBUcmFuc3BsYW50YXRpb24vKmFkdmVyc2UgZWZmZWN0czwva2V5d29y

ZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TGVjdGlucywgQy1UeXBlPC9rZXl3

b3JkPjxrZXl3b3JkPkxldWtvY3l0ZXMsIE1vbm9udWNsZWFyL2ltbXVub2xvZ3kvbWV0YWJvbGlz

bTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1lbWJyYW5lIFByb3Rl

aW5zL2RlZmljaWVuY3kvKmdlbmV0aWNzLyppbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPk1p

Y2U8L2tleXdvcmQ+PGtleXdvcmQ+TWljZSwgS25vY2tvdXQ8L2tleXdvcmQ+PGtleXdvcmQ+TWlk

ZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TmVydmUgVGlzc3VlIFByb3RlaW5zL2RlZmljaWVu

Y3kvKmdlbmV0aWNzLyppbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlBvbHltb3JwaGlzbSwg

R2VuZXRpYy8qaW1tdW5vbG9neTwva2V5d29yZD48a2V5d29yZD5Zb3VuZyBBZHVsdDwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RGVj

IDk8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTI4LTAwMjAgKEVsZWN0cm9uaWMp

JiN4RDswMDA2LTQ5NzEgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwODA3ODg2PC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzIwODA3ODg2PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVj

dHJvbmljLXJlc291cmNlLW51bT4xMC4xMTgyL2Jsb29kLTIwMTAtMDQtMjc5MzA3PC9lbGVjdHJv

bmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb2NodWQ8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+MjYyNjg8L1JlY051bT48RGlzcGxheVRleHQ+WzM0LTM3XTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4yNjI2ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+MjYyNjg8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJvY2h1ZCwgUC4gWS48L2F1

dGhvcj48YXV0aG9yPkNoaWVuLCBKLiBXLjwvYXV0aG9yPjxhdXRob3I+TWFyciwgSy4gQS48L2F1

dGhvcj48YXV0aG9yPkxlaXNlbnJpbmcsIFcuIE0uPC9hdXRob3I+PGF1dGhvcj5VcHRvbiwgQS48

L2F1dGhvcj48YXV0aG9yPkphbmVyLCBNLjwvYXV0aG9yPjxhdXRob3I+Um9kcmlndWVzLCBTLiBE

LjwvYXV0aG9yPjxhdXRob3I+TGksIFMuPC9hdXRob3I+PGF1dGhvcj5IYW5zZW4sIEouIEEuPC9h

dXRob3I+PGF1dGhvcj5aaGFvLCBMLiBQLjwvYXV0aG9yPjxhdXRob3I+QWRlcmVtLCBBLjwvYXV0

aG9yPjxhdXRob3I+Qm9lY2toLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

YXV0aC1hZGRyZXNzPkluc3RpdHV0ZSBmb3IgU3lzdGVtcyBCaW9sb2d5LCBGcmVkIEh1dGNoaW5z

b24gQ2FuY2VyIFJlc2VhcmNoIENlbnRlciwgU2VhdHRsZSwgV0EgOTgxMDksIFVTQS48L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Ub2xsLWxpa2UgcmVjZXB0b3IgNCBwb2x5bW9ycGhpc21z

IGFuZCBhc3BlcmdpbGxvc2lzIGluIHN0ZW0tY2VsbCB0cmFuc3BsYW50YXRpb248L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+TiBFbmdsIEogTWVkPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5U

aGUgTmV3IEVuZ2xhbmQgam91cm5hbCBvZiBtZWRpY2luZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk4gRW5nbCBKIE1lZDwvZnVsbC10aXRsZT48L3BlcmlvZGlj

YWw+PHBhZ2VzPjE3NjYtNzc8L3BhZ2VzPjx2b2x1bWU+MzU5PC92b2x1bWU+PG51bWJlcj4xNzwv

bnVtYmVyPjxlZGl0aW9uPjIwMDgvMTAvMjQ8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFk

dWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFuYWx5c2lzIG9mIFZhcmlhbmNlPC9rZXl3b3JkPjxrZXl3

b3JkPkFzcGVyZ2lsbG9zaXMvKmdlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVz

IGZ1bWlnYXR1czwva2V5d29yZD48a2V5d29yZD5DYXNlLUNvbnRyb2wgU3R1ZGllczwva2V5d29y

ZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+R2VuZXRpYyBQcmVkaXNwb3NpdGlv

biB0byBEaXNlYXNlPC9rZXl3b3JkPjxrZXl3b3JkPkhhcGxvdHlwZXM8L2tleXdvcmQ+PGtleXdv

cmQ+KkhlbWF0b3BvaWV0aWMgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVj

dHMvbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5J

bmNpZGVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+TGlua2FnZSBEaXNlcXVpbGlicml1bTwva2V5d29y

ZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxr

ZXl3b3JkPipQb2x5bW9ycGhpc20sIFNpbmdsZSBOdWNsZW90aWRlPC9rZXl3b3JkPjxrZXl3b3Jk

PlByb3BvcnRpb25hbCBIYXphcmRzIE1vZGVsczwva2V5d29yZD48a2V5d29yZD5SaXNrIEFzc2Vz

c21lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+VG9sbC1MaWtlIFJlY2VwdG9yIDQvKmdlbmV0aWNzPC9r

ZXl3b3JkPjxrZXl3b3JkPlRvbGwtTGlrZSBSZWNlcHRvcnMvZ2VuZXRpY3M8L2tleXdvcmQ+PGtl

eXdvcmQ+VHJhbnNwbGFudGF0aW9uLCBIb21vbG9nb3VzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMDg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5PY3QgMjM8L2RhdGU+PC9wdWIt

ZGF0ZXM+PC9kYXRlcz48aXNibj4xNTMzLTQ0MDYgKEVsZWN0cm9uaWMpJiN4RDswMDI4LTQ3OTMg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE4OTQ2MDYyPC9hY2Nlc3Npb24tbnVtPjx3

b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRyYW11cmFsJiN4RDtSZXNlYXJj

aCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0JiN4RDtWYWxpZGF0aW9uIFN0dWRpZXM8L3dv

cmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWgu

Z292L3B1Ym1lZC8xODk0NjA2MjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj4y

NjU2NjEwPC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDU2L05FSk1vYTA4

MDI2Mjk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlphYXM8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFy

PjxSZWNOdW0+MjYyODY8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI2Mjg2PC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhy

bXh0ZjloOTBwdzJkeHpwdGVwIj4yNjI4Njwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBu

YW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3Jz

PjxhdXRob3I+WmFhcywgQS4gSy48L2F1dGhvcj48YXV0aG9yPkxpYW8sIEcuPC9hdXRob3I+PGF1

dGhvcj5DaGllbiwgSi4gVy48L2F1dGhvcj48YXV0aG9yPldlaW5iZXJnLCBDLjwvYXV0aG9yPjxh

dXRob3I+U2hvcmUsIEQuPC9hdXRob3I+PGF1dGhvcj5HaWxlcywgUy4gUy48L2F1dGhvcj48YXV0

aG9yPk1hcnIsIEsuIEEuPC9hdXRob3I+PGF1dGhvcj5Vc3VrYSwgSi48L2F1dGhvcj48YXV0aG9y

PkJ1cmNoLCBMLiBILjwvYXV0aG9yPjxhdXRob3I+UGVyZXJhLCBMLjwvYXV0aG9yPjxhdXRob3I+

UGVyZmVjdCwgSi4gUi48L2F1dGhvcj48YXV0aG9yPlBlbHR6LCBHLjwvYXV0aG9yPjxhdXRob3I+

U2Nod2FydHosIEQuIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFk

ZHJlc3M+RHVrZSBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBEdXJoYW0sIE5vcnRoIENhcm9s

aW5hLCBVbml0ZWQgU3RhdGVzIG9mIEFtZXJpY2EuIGFpbWVlLnphYXNAZHVrZS5lZHU8L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5QbGFzbWlub2dlbiBhbGxlbGVzIGluZmx1ZW5jZSBzdXNj

ZXB0aWJpbGl0eSB0byBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPlBMb1MgR2VuZXQ8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlBMb1MgZ2VuZXRpY3M8

L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QTG9TIEdlbmV0PC9m

dWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+ZTEwMDAxMDE8L3BhZ2VzPjx2b2x1bWU+NDwv

dm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxlZGl0aW9uPjIwMDgvMDYvMjE8L2VkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPipBbGxlbGVzPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdv

cmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qZ2VuZXRpY3MvKm1pY3JvYmlvbG9neS9tb3J0YWxp

dHkvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzIGZ1bWlnYXR1cy9pbW11

bm9sb2d5L3BhdGhvZ2VuaWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxr

ZXl3b3JkPipHZW5ldGljIFByZWRpc3Bvc2l0aW9uIHRvIERpc2Vhc2U8L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcgRGlzZWFzZXMsIEZ1bmdhbC8qZ2VuZXRp

Y3MvaW1tdW5vbG9neS8qbWljcm9iaW9sb2d5L21vcnRhbGl0eTwva2V5d29yZD48a2V5d29yZD5N

aWNlPC9rZXl3b3JkPjxrZXl3b3JkPk1pY2UsIEluYnJlZCBBPC9rZXl3b3JkPjxrZXl3b3JkPk1p

Y2UsIEluYnJlZCBBS1I8L2tleXdvcmQ+PGtleXdvcmQ+TWljZSwgSW5icmVkIEJBTEIgQzwva2V5

d29yZD48a2V5d29yZD5NaWNlLCBJbmJyZWQgQzNIPC9rZXl3b3JkPjxrZXl3b3JkPk1pY2UsIElu

YnJlZCBDNTdCTDwva2V5d29yZD48a2V5d29yZD5NaWNlLCBJbmJyZWQgREJBPC9rZXl3b3JkPjxr

ZXl3b3JkPk1pY2UsIEluYnJlZCBNUkwgbHByPC9rZXl3b3JkPjxrZXl3b3JkPk1pY2UsIEluYnJl

ZCBOWkI8L2tleXdvcmQ+PGtleXdvcmQ+TWljZSwgS25vY2tvdXQ8L2tleXdvcmQ+PGtleXdvcmQ+

UGxhc21pbm9nZW4vKmdlbmV0aWNzL3BoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+U2lnbmFs

IFRyYW5zZHVjdGlvbi8qZ2VuZXRpY3M8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAwODwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVz

Pjxpc2JuPjE1NTMtNzQwNCAoRWxlY3Ryb25pYykmI3hEOzE1NTMtNzM5MCAoTGlua2luZyk8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+MTg1NjY2NzI8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5Db21w

YXJhdGl2ZSBTdHVkeSYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRyYW11cmFsJiN4

RDtSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEludHJhbXVyYWw8L3dvcmstdHlwZT48dXJscz48

cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xODU2

NjY3MjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj4yNDIzNDg1PC9jdXN0b20y

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMzcxL2pvdXJuYWwucGdlbi4xMDAwMTAxPC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48

L0NpdGU+PENpdGU+PEF1dGhvcj5DdW5oYTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051

bT4yNjI5MjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjYyOTI8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5

MHB3MmR4enB0ZXAiPjI2MjkyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5DdW5oYSwgQy48L2F1dGhvcj48YXV0aG9yPkF2ZXJzYSwgRi48L2F1dGhvcj48YXV0aG9yPkxh

Y2VyZGEsIEouIEYuPC9hdXRob3I+PGF1dGhvcj5CdXNjYSwgQS48L2F1dGhvcj48YXV0aG9yPkt1

cnphaSwgTy48L2F1dGhvcj48YXV0aG9yPkdydWJlLCBNLjwvYXV0aG9yPjxhdXRob3I+TG9mZmxl

ciwgSi48L2F1dGhvcj48YXV0aG9yPk1hZXJ0ZW5zLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+QmVs

bCwgQS4gUy48L2F1dGhvcj48YXV0aG9yPkluZm9yemF0bywgQS48L2F1dGhvcj48YXV0aG9yPkJh

cmJhdGksIEUuPC9hdXRob3I+PGF1dGhvcj5BbG1laWRhLCBCLjwvYXV0aG9yPjxhdXRob3I+U2Fu

dG9zIGUgU291c2EsIFAuPC9hdXRob3I+PGF1dGhvcj5CYXJidWksIEEuPC9hdXRob3I+PGF1dGhv

cj5Qb3RlbnphLCBMLjwvYXV0aG9yPjxhdXRob3I+Q2FpcmEsIE0uPC9hdXRob3I+PGF1dGhvcj5S

b2RyaWd1ZXMsIEYuPC9hdXRob3I+PGF1dGhvcj5TYWx2YXRvcmksIEcuPC9hdXRob3I+PGF1dGhv

cj5QYWdhbm8sIEwuPC9hdXRob3I+PGF1dGhvcj5MdXBwaSwgTS48L2F1dGhvcj48YXV0aG9yPk1h

bnRvdmFuaSwgQS48L2F1dGhvcj48YXV0aG9yPlZlbGFyZGksIEEuPC9hdXRob3I+PGF1dGhvcj5S

b21hbmksIEwuPC9hdXRob3I+PGF1dGhvcj5DYXJ2YWxobywgQS48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5UaGUgYXV0aG9ycyZhcG9zOyBhZmZpbGlhdGlv

bnMgYXJlIGxpc3RlZCBpbiB0aGUgQXBwZW5kaXguPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0

bGU+R2VuZXRpYyBQVFgzIGRlZmljaWVuY3kgYW5kIGFzcGVyZ2lsbG9zaXMgaW4gc3RlbS1jZWxs

IHRyYW5zcGxhbnRhdGlvbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OIEVuZ2wgSiBNZWQ8L3Nl

Y29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlRoZSBOZXcgRW5nbGFuZCBqb3VybmFsIG9mIG1lZGlj

aW5lPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TiBFbmdsIEog

TWVkPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NDIxLTMyPC9wYWdlcz48dm9sdW1l

PjM3MDwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxlZGl0aW9uPjIwMTQvMDEvMzE8L2VkaXRp

b24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9z

aXMvKmdlbmV0aWNzL2ltbXVub2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Qy1SZWFjdGl2ZSBQcm90

ZWluLypkZWZpY2llbmN5L2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29y

ZD48a2V5d29yZD5HZW5ldGljIFByZWRpc3Bvc2l0aW9uIHRvIERpc2Vhc2U8L2tleXdvcmQ+PGtl

eXdvcmQ+SGFwbG90eXBlczwva2V5d29yZD48a2V5d29yZD4qSGVtYXRvcG9pZXRpYyBTdGVtIENl

bGwgVHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5

d29yZD5JbW11bml0eSwgSW5uYXRlLypnZW5ldGljczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9r

ZXl3b3JkPjxrZXl3b3JkPk5ldXRyb3BoaWxzLyppbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3Jk

PipQb2x5bW9ycGhpc20sIFNpbmdsZSBOdWNsZW90aWRlPC9rZXl3b3JkPjxrZXl3b3JkPlNlcnVt

IEFteWxvaWQgUC1Db21wb25lbnQvKmRlZmljaWVuY3kvZ2VuZXRpY3M8L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48cHViLWRhdGVzPjxkYXRlPkphbiAzMDwvZGF0

ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzMtNDQwNiAoRWxlY3Ryb25pYykmI3hEOzAw

MjgtNDc5MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjQ0NzY0MzI8L2FjY2Vzc2lv

bi1udW0+PHdvcmstdHlwZT5NdWx0aWNlbnRlciBTdHVkeSYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwg

Tm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o

dHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI0NDc2NDMyPC91cmw+PC9yZWxhdGVk

LXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDU2L05FSk1vYTEyMTEx

NjE8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVj

b3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkN1bmhhPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48

UmVjTnVtPjIyNDwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjI0PC9yZWMtbnVtYmVyPjxm

b3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBz

cHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9IjE0MTM4MzIzMjEiPjIyNDwva2V5PjwvZm9yZWlnbi1r

ZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJp

YnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Q3VuaGEsIEMuPC9hdXRob3I+PGF1dGhvcj5EaSBJYW5u

aSwgTS48L2F1dGhvcj48YXV0aG9yPkJvenphLCBTLjwvYXV0aG9yPjxhdXRob3I+R2lvdmFubmlu

aSwgRy48L2F1dGhvcj48YXV0aG9yPlphZ2FyZWxsYSwgUy48L2F1dGhvcj48YXV0aG9yPlplbGFu

dGUsIFQuPC9hdXRob3I+PGF1dGhvcj5EJmFwb3M7QW5nZWxvLCBDLjwvYXV0aG9yPjxhdXRob3I+

UGllcmluaSwgQS48L2F1dGhvcj48YXV0aG9yPlBpdHp1cnJhLCBMLjwvYXV0aG9yPjxhdXRob3I+

RmFsemV0dGksIEYuPC9hdXRob3I+PGF1dGhvcj5DYXJvdHRpLCBBLjwvYXV0aG9yPjxhdXRob3I+

UGVycnVjY2lvLCBLLjwvYXV0aG9yPjxhdXRob3I+TGF0Z2UsIEouIFAuPC9hdXRob3I+PGF1dGhv

cj5Sb2RyaWd1ZXMsIEYuPC9hdXRob3I+PGF1dGhvcj5WZWxhcmRpLCBBLjwvYXV0aG9yPjxhdXRo

b3I+QXZlcnNhLCBGLjwvYXV0aG9yPjxhdXRob3I+Um9tYW5pLCBMLjwvYXV0aG9yPjxhdXRob3I+

Q2FydmFsaG8sIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl

c3M+TWljcm9iaW9sb2d5IFNlY3Rpb24sIERlcGFydG1lbnQgb2YgRXhwZXJpbWVudGFsIE1lZGlj

aW5lIGFuZCBCaW9jaGVtaWNhbCBTY2llbmNlcywgVW5pdmVyc2l0eSBvZiBQZXJ1Z2lhLCBQZXJ1

Z2lhLCBJdGFseS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EZWN0aW4tMSBZMjM4WCBw

b2x5bW9ycGhpc20gYXNzb2NpYXRlcyB3aXRoIHN1c2NlcHRpYmlsaXR5IHRvIGludmFzaXZlIGFz

cGVyZ2lsbG9zaXMgaW4gaGVtYXRvcG9pZXRpYyB0cmFuc3BsYW50YXRpb24gdGhyb3VnaCBpbXBh

aXJtZW50IG9mIGJvdGggcmVjaXBpZW50LSBhbmQgZG9ub3ItZGVwZW5kZW50IG1lY2hhbmlzbXMg

b2YgYW50aWZ1bmdhbCBpbW11bml0eTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5CbG9vZDwvc2Vj

b25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Qmxvb2Q8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5CbG9vZDwvZnVsbC10aXRsZT48YWJici0xPkJsb29kPC9hYmJyLTE+

PGFiYnItMj5CbG9vZDwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+Qmxvb2Q8L2Z1bGwtdGl0bGU+PGFiYnItMT5CbG9vZDwvYWJici0xPjxhYmJyLTI+Qmxv

b2Q8L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz41Mzk0LTQwMjwvcGFnZXM+PHZvbHVt

ZT4xMTY8L3ZvbHVtZT48bnVtYmVyPjI0PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xl

c2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5

d29yZD48a2V5d29yZD5BbmltYWxzPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvKmV0

aW9sb2d5L2dlbmV0aWNzL2ltbXVub2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdv

cmQ+PGtleXdvcmQ+Q3l0b2tpbmVzL2Jpb3N5bnRoZXNpczwva2V5d29yZD48a2V5d29yZD5EaXNl

YXNlIFN1c2NlcHRpYmlsaXR5LypldGlvbG9neTwva2V5d29yZD48a2V5d29yZD5FcGl0aGVsaWFs

IENlbGxzL2ltbXVub2xvZ3kvbWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tl

eXdvcmQ+PGtleXdvcmQ+RnVuZ2kvaW1tdW5vbG9neTwva2V5d29yZD48a2V5d29yZD5IZW1hdG9w

b2lldGljIFN0ZW0gQ2VsbCBUcmFuc3BsYW50YXRpb24vKmFkdmVyc2UgZWZmZWN0czwva2V5d29y

ZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TGVjdGlucywgQy1UeXBlPC9rZXl3

b3JkPjxrZXl3b3JkPkxldWtvY3l0ZXMsIE1vbm9udWNsZWFyL2ltbXVub2xvZ3kvbWV0YWJvbGlz

bTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1lbWJyYW5lIFByb3Rl

aW5zL2RlZmljaWVuY3kvKmdlbmV0aWNzLyppbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPk1p

Y2U8L2tleXdvcmQ+PGtleXdvcmQ+TWljZSwgS25vY2tvdXQ8L2tleXdvcmQ+PGtleXdvcmQ+TWlk

ZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TmVydmUgVGlzc3VlIFByb3RlaW5zL2RlZmljaWVu

Y3kvKmdlbmV0aWNzLyppbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlBvbHltb3JwaGlzbSwg

R2VuZXRpYy8qaW1tdW5vbG9neTwva2V5d29yZD48a2V5d29yZD5Zb3VuZyBBZHVsdDwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RGVj

IDk8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTI4LTAwMjAgKEVsZWN0cm9uaWMp

JiN4RDswMDA2LTQ5NzEgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwODA3ODg2PC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzIwODA3ODg2PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVj

dHJvbmljLXJlc291cmNlLW51bT4xMC4xMTgyL2Jsb29kLTIwMTAtMDQtMjc5MzA3PC9lbGVjdHJv

bmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [34-37].In solid organ transplant recipients, the intensity of immunosuppression to prevent or treat allograft rejection, colonization, and coinfection with CMV drive the risk of invasive aspergillosis. As in allogeneic HSCT recipients, polymorphisms in specific host defense genes in solid organ transplant recipients can also influence the risk of aspergillosis PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Xb2p0b3dpY3o8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy

PjxSZWNOdW0+NjM1PC9SZWNOdW0+PERpc3BsYXlUZXh0PlszOCwgMzldPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjYzNTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0

YW1wPSIxNDM5MzEzOTQzIj42MzU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPldvanRvd2ljeiwgQS48L2F1dGhvcj48YXV0aG9yPkxlY29tcHRlLCBULiBELjwvYXV0aG9y

PjxhdXRob3I+QmliZXJ0LCBTLjwvYXV0aG9yPjxhdXRob3I+TWFudWVsLCBPLjwvYXV0aG9yPjxh

dXRob3I+UnVlZ2VyLCBTLjwvYXV0aG9yPjxhdXRob3I+QmVyZ2VyLCBDLjwvYXV0aG9yPjxhdXRo

b3I+Qm9nZ2lhbiwgSy48L2F1dGhvcj48YXV0aG9yPkN1c2luaSwgQS48L2F1dGhvcj48YXV0aG9y

PkdhcnpvbmksIEMuPC9hdXRob3I+PGF1dGhvcj5IaXJzY2gsIEguPC9hdXRob3I+PGF1dGhvcj5L

aGFubmEsIE4uPC9hdXRob3I+PGF1dGhvcj5NdWVsbGVyLCBOLiBKLjwvYXV0aG9yPjxhdXRob3I+

TWV5bGFuLCBQLiBSLjwvYXV0aG9yPjxhdXRob3I+UGFzY3VhbCwgTS48L2F1dGhvcj48YXV0aG9y

PnZhbiBEZWxkZW4sIEMuPC9hdXRob3I+PGF1dGhvcj5Cb2NodWQsIFAuIFkuPC9hdXRob3I+PGF1

dGhvcj5Td2lzcyBUcmFuc3BsYW50IENvaG9ydCwgU3R1ZHk8L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5JbmZlY3Rpb3VzIERpc2Vhc2VzIFNlcnZpY2UsIFVu

aXZlcnNpdHkgSG9zcGl0YWwgYW5kIFVuaXZlcnNpdHkgb2YgTGF1c2FubmUuJiN4RDtTZXJ2aWNl

IG9mIFRyYW5zcGxhbnRhdGlvbiBhbmQgU2VydmljZSBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzLCBV

bml2ZXJzaXR5IEhvc3BpdGFscyBvZiBHZW5ldmEuJiN4RDtJbmZlY3Rpb3VzIERpc2Vhc2VzIFNl

cnZpY2UsIFVuaXZlcnNpdHkgSG9zcGl0YWwgYW5kIFVuaXZlcnNpdHkgb2YgTGF1c2FubmUgVHJh

bnNwbGFudGF0aW9uIENlbnRlciwgRGVwYXJ0bWVudCBvZiBTdXJnZXJ5LiYjeEQ7SW5zdGl0dXRl

IG9mIFNvY2lhbCBhbmQgUHJldmVudGl2ZSBNZWRpY2luZSwgVW5pdmVyc2l0eSBIb3NwaXRhbCBh

bmQgVW5pdmVyc2l0eSBvZiBMYXVzYW5uZSBTd2lzcyBJbnN0aXR1dGUgb2YgQmlvaW5mb3JtYXRp

Y3MsIExhdXNhbm5lLiYjeEQ7RGl2aXNpb24gb2YgSW5mZWN0aW91cyBEaXNlYXNlcyBhbmQgSG9z

cGl0YWwgRXBpZGVtaW9sb2d5LCBVbml2ZXJzaXR5IENoaWxkcmVuJmFwb3M7cyBIb3NwaXRhbCBa

dXJpY2guJiN4RDtEaXZpc2lvbiBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzIGFuZCBIb3NwaXRhbCBF

cGlkZW1pb2xvZ3ksIENhbnRvbmFsIEhvc3BpdGFsIFN0IEdhbGxlbi4mI3hEO0RlcGFydG1lbnQg

b2YgSW5mZWN0aW91cyBEaXNlYXNlcywgSW5zZWxzcGl0YWwsIEJlcm4gVW5pdmVyc2l0eSBIb3Nw

aXRhbCBhbmQgVW5pdmVyc2l0eSBvZiBCZXJuLiYjeEQ7RGVwYXJ0bWVudCBvZiBJbmZlY3Rpb3Vz

IERpc2Vhc2VzLCBJbnNlbHNwaXRhbCwgQmVybiBVbml2ZXJzaXR5IEhvc3BpdGFsIGFuZCBVbml2

ZXJzaXR5IG9mIEJlcm4gRGVwYXJ0bWVudHMgb2YgSW50ZXJuYWwgTWVkaWNpbmUgYW5kIEluZmVj

dGlvdXMgRGlzZWFzZSwgQ2xpbmljYSBMdWdhbmVzZSwgTHVnYW5vLiYjeEQ7RGl2aXNpb24gb2Yg

SW5mZWN0aW91cyBEaXNlYXNlcyBhbmQgSG9zcGl0YWwgRXBpZGVtaW9sb2d5LCBVbml2ZXJzaXR5

IEhvc3BpdGFsIG9mIEJhc2VsLiYjeEQ7RGl2aXNpb24gb2YgSW5mZWN0aW91cyBEaXNlYXNlcyBh

bmQgSG9zcGl0YWwgRXBpZGVtaW9sb2d5LCBVbml2ZXJzaXR5IEhvc3BpdGFsIFp1cmljaC4mI3hE

O0luZmVjdGlvdXMgRGlzZWFzZXMgU2VydmljZSwgVW5pdmVyc2l0eSBIb3NwaXRhbCBhbmQgVW5p

dmVyc2l0eSBvZiBMYXVzYW5uZSBJbnN0aXR1dGUgb2YgTWljcm9iaW9sb2d5LCBVbml2ZXJzaXR5

IEhvc3BpdGFsIGFuZCBVbml2ZXJzaXR5IG9mIExhdXNhbm5lLCBTd2l0emVybGFuZC4mI3hEO1Ry

YW5zcGxhbnRhdGlvbiBDZW50ZXIsIERlcGFydG1lbnQgb2YgU3VyZ2VyeS48L2F1dGgtYWRkcmVz

cz48dGl0bGVzPjx0aXRsZT5QVFgzIFBvbHltb3JwaGlzbXMgYW5kIEludmFzaXZlIE1vbGQgSW5m

ZWN0aW9ucyBBZnRlciBTb2xpZCBPcmdhbiBUcmFuc3BsYW50PC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkNsaW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFi

YnItMT5DbGluLiBJbmZlY3QuIERpcy48L2FiYnItMT48YWJici0yPkNsaW4gSW5mZWN0IERpczwv

YWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+NjE5LTIyPC9wYWdlcz48dm9sdW1lPjYxPC92b2x1

bWU+PG51bWJlcj40PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPlB0eDM8L2tleXdvcmQ+PGtl

eXdvcmQ+U25wPC9rZXl3b3JkPjxrZXl3b3JkPmdlbmV0aWMgc3VzY2VwdGliaWxpdHk8L2tleXdv

cmQ+PGtleXdvcmQ+aW5uYXRlIGltbXVuaXR5PC9rZXl3b3JkPjxrZXl3b3JkPnNvbGlkIG9yZ2Fu

IHRyYW5zcGxhbnQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48

cHViLWRhdGVzPjxkYXRlPkF1ZyAxNTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1

MzctNjU5MSAoRWxlY3Ryb25pYykmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MjU5NzcyNjg8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjU5NzcyNjg8L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvY2lkL2NpdjM4

NjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+

V29qdG93aWN6PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVjTnVtPjYzNjwvUmVjTnVtPjxy

ZWNvcmQ+PHJlYy1udW1iZXI+NjM2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3Rh

bXA9IjE0MzkzMTM5ODkiPjYzNjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK

b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo

b3I+V29qdG93aWN6LCBBLjwvYXV0aG9yPjxhdXRob3I+R3Jlc25pZ3QsIE0uIFMuPC9hdXRob3I+

PGF1dGhvcj5MZWNvbXB0ZSwgVC48L2F1dGhvcj48YXV0aG9yPkJpYmVydCwgUy48L2F1dGhvcj48

YXV0aG9yPk1hbnVlbCwgTy48L2F1dGhvcj48YXV0aG9yPkpvb3N0ZW4sIEwuIEEuPC9hdXRob3I+

PGF1dGhvcj5SdWVnZXIsIFMuPC9hdXRob3I+PGF1dGhvcj5CZXJnZXIsIEMuPC9hdXRob3I+PGF1

dGhvcj5Cb2dnaWFuLCBLLjwvYXV0aG9yPjxhdXRob3I+Q3VzaW5pLCBBLjwvYXV0aG9yPjxhdXRo

b3I+R2Fyem9uaSwgQy48L2F1dGhvcj48YXV0aG9yPkhpcnNjaCwgSC4gSC48L2F1dGhvcj48YXV0

aG9yPldlaXNzZXIsIE0uPC9hdXRob3I+PGF1dGhvcj5NdWVsbGVyLCBOLiBKLjwvYXV0aG9yPjxh

dXRob3I+TWV5bGFuLCBQLiBSLjwvYXV0aG9yPjxhdXRob3I+U3RlaWdlciwgSi48L2F1dGhvcj48

YXV0aG9yPkt1dGFsaWssIFouPC9hdXRob3I+PGF1dGhvcj5QYXNjdWFsLCBNLjwvYXV0aG9yPjxh

dXRob3I+dmFuIERlbGRlbiwgQy48L2F1dGhvcj48YXV0aG9yPnZhbiBkZSBWZWVyZG9uaywgRi4g

TC48L2F1dGhvcj48YXV0aG9yPkJvY2h1ZCwgUC4gWS48L2F1dGhvcj48YXV0aG9yPlN3aXNzIFRy

YW5zcGxhbnQgQ29ob3J0LCBTdHVkeTwvYXV0aG9yPjxhdXRob3I+U3dpc3MgVHJhbnNwbGFudCBD

b2hvcnQgU3R1ZHksIFN0Y3M8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt

YWRkcmVzcz5JbmZlY3Rpb3VzIERpc2Vhc2VzIFNlcnZpY2UuJiN4RDtEZXBhcnRtZW50IG9mIElu

dGVybmFsIE1lZGljaW5lLCBSYWRib3VkIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIsIE5pam1l

Z2VuLCBUaGUgTmV0aGVybGFuZHMuJiN4RDtTZXJ2aWNlIG9mIFRyYW5zcGxhbnRhdGlvbiBTZXJ2

aWNlIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIFVuaXZlcnNpdHkgSG9zcGl0YWxzIG9mIEdlbmV2

YS4mI3hEO0luZmVjdGlvdXMgRGlzZWFzZXMgU2VydmljZSBUcmFuc3BsYW50YXRpb24gQ2VudGVy

LCBEZXBhcnRtZW50IG9mIFN1cmdlcnkuJiN4RDtJbnN0aXR1dGUgb2YgU29jaWFsIGFuZCBQcmV2

ZW50aXZlIE1lZGljaW5lIFN3aXNzIEluc3RpdHV0ZSBvZiBCaW9pbmZvcm1hdGljcywgTGF1c2Fu

bmUuJiN4RDtEaXZpc2lvbiBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzIGFuZCBIb3NwaXRhbCBFcGlk

ZW1pb2xvZ3ksIFVuaXZlcnNpdHkgQ2hpbGRyZW4mYXBvcztzIEhvc3BpdGFsIFp1cmljaC4mI3hE

O0RpdmlzaW9uIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMgYW5kIEhvc3BpdGFsIEVwaWRlbWlvbG9n

eSwgQ2FudG9uYWwgSG9zcGl0YWwgU3QuIEdhbGxlbi4mI3hEO0RlcGFydG1lbnQgb2YgSW5mZWN0

aW91cyBEaXNlYXNlcywgSW5zZWxzcGl0YWwsIEJlcm4gVW5pdmVyc2l0eSBIb3NwaXRhbCBhbmQg

VW5pdmVyc2l0eSBvZiBCZXJuLiYjeEQ7RGVwYXJ0bWVudCBvZiBJbmZlY3Rpb3VzIERpc2Vhc2Vz

LCBJbnNlbHNwaXRhbCwgQmVybiBVbml2ZXJzaXR5IEhvc3BpdGFsIGFuZCBVbml2ZXJzaXR5IG9m

IEJlcm4gRGVwYXJ0bWVudCBvZiBJbnRlcm5hbCBNZWRpY2luZS4mI3hEO0RpdmlzaW9uIG9mIElu

ZmVjdGlvdXMgRGlzZWFzZXMgYW5kIEhvc3BpdGFsIEVwaWRlbWlvbG9neS4mI3hEO0RpdmlzaW9u

IG9mIEluZmVjdGlvdXMgRGlzZWFzZXMgYW5kIEhvc3BpdGFsIEVwaWRlbWlvbG9neSwgVW5pdmVy

c2l0eSBIb3NwaXRhbCBadXJpY2guJiN4RDtJbmZlY3Rpb3VzIERpc2Vhc2VzIFNlcnZpY2UgSW5z

dGl0dXRlIG9mIE1pY3JvYmlvbG9neSwgVW5pdmVyc2l0eSBIb3NwaXRhbCBhbmQgVW5pdmVyc2l0

eSBvZiBMYXVzYW5uZS4mI3hEO0NsaW5pYyBmb3IgVHJhbnNwbGFudGF0aW9uIEltbXVub2xvZ3kg

YW5kIE5lcGhyb2xvZ3ksIFVuaXZlcnNpdHkgSG9zcGl0YWwgb2YgQmFzZWwsIFN3aXR6ZXJsYW5k

LiYjeEQ7SW5mZWN0aW91cyBEaXNlYXNlcyBTZXJ2aWNlIFN3aXNzIEluc3RpdHV0ZSBvZiBCaW9p

bmZvcm1hdGljcywgTGF1c2FubmUuJiN4RDtUcmFuc3BsYW50YXRpb24gQ2VudGVyLCBEZXBhcnRt

ZW50IG9mIFN1cmdlcnkuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+SUwxQiBhbmQgREVG

QjEgUG9seW1vcnBoaXNtcyBJbmNyZWFzZSBTdXNjZXB0aWJpbGl0eSB0byBJbnZhc2l2ZSBNb2xk

IEluZmVjdGlvbiBBZnRlciBTb2xpZC1PcmdhbiBUcmFuc3BsYW50YXRpb248L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+SiBJbmZlY3QgRGlzPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRp

dGxlPjxhYmJyLTE+Si4gSW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5KIEluZmVjdCBEaXM8

L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjE2NDYtNTc8L3BhZ2VzPjx2b2x1bWU+MjExPC92

b2x1bWU+PG51bWJlcj4xMDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29y

ZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkNvaG9ydCBTdHVkaWVzPC9rZXl3b3Jk

PjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5GdW5naS8qaXNvbGF0aW9uICZhbXA7

IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5HZW5ldGljIEFzc29jaWF0aW9uIFN0dWRp

ZXM8L2tleXdvcmQ+PGtleXdvcmQ+KkdlbmV0aWMgUHJlZGlzcG9zaXRpb24gdG8gRGlzZWFzZTwv

a2V5d29yZD48a2V5d29yZD5HZW5vdHlwZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdv

cmQ+PGtleXdvcmQ+SW50ZXJsZXVraW4tMWJldGEvKmdlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3Jk

Pk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXlj

b3Nlcy8qZXBpZGVtaW9sb2d5L2dlbmV0aWNzL2ltbXVub2xvZ3kvbWljcm9iaW9sb2d5PC9rZXl3

b3JkPjxrZXl3b3JkPk9yZ2FuIFRyYW5zcGxhbnRhdGlvbi8qYWR2ZXJzZSBlZmZlY3RzPC9rZXl3

b3JkPjxrZXl3b3JkPipQb2x5bW9ycGhpc20sIFNpbmdsZSBOdWNsZW90aWRlPC9rZXl3b3JkPjxr

ZXl3b3JkPlRyYW5zcGxhbnQgUmVjaXBpZW50czwva2V5d29yZD48a2V5d29yZD5iZXRhLURlZmVu

c2lucy8qZ2VuZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+YXNwZXJnaWxsb3Npczwva2V5d29yZD48

a2V5d29yZD5nZW5ldGljIHN1c2NlcHRpYmlsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPmlubmF0ZSBp

bW11bml0eTwva2V5d29yZD48a2V5d29yZD5pbnRlcmxldWtpbi0xIGJldGE8L2tleXdvcmQ+PGtl

eXdvcmQ+aW52YXNpdmUgbW9sZCBpbmZlY3Rpb25zPC9rZXl3b3JkPjxrZXl3b3JkPnNpbmdsZSBu

dWNsZW90aWRlIHBvbHltb3JwaGlzbTwva2V5d29yZD48a2V5d29yZD5zb2xpZCBvcmdhbiB0cmFu

c3BsYW50PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1k

YXRlcz48ZGF0ZT5NYXkgMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY2

MTMgKEVsZWN0cm9uaWMpJiN4RDswMDIyLTE4OTkgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24t

bnVtPjI1Mzk4NDU2PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRw

Oi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI1Mzk4NDU2PC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkzL2luZmRpcy9qaXU2MzY8

L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Xb2p0b3dpY3o8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy

PjxSZWNOdW0+NjM1PC9SZWNOdW0+PERpc3BsYXlUZXh0PlszOCwgMzldPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjYzNTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0

YW1wPSIxNDM5MzEzOTQzIj42MzU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPldvanRvd2ljeiwgQS48L2F1dGhvcj48YXV0aG9yPkxlY29tcHRlLCBULiBELjwvYXV0aG9y

PjxhdXRob3I+QmliZXJ0LCBTLjwvYXV0aG9yPjxhdXRob3I+TWFudWVsLCBPLjwvYXV0aG9yPjxh

dXRob3I+UnVlZ2VyLCBTLjwvYXV0aG9yPjxhdXRob3I+QmVyZ2VyLCBDLjwvYXV0aG9yPjxhdXRo

b3I+Qm9nZ2lhbiwgSy48L2F1dGhvcj48YXV0aG9yPkN1c2luaSwgQS48L2F1dGhvcj48YXV0aG9y

PkdhcnpvbmksIEMuPC9hdXRob3I+PGF1dGhvcj5IaXJzY2gsIEguPC9hdXRob3I+PGF1dGhvcj5L

aGFubmEsIE4uPC9hdXRob3I+PGF1dGhvcj5NdWVsbGVyLCBOLiBKLjwvYXV0aG9yPjxhdXRob3I+

TWV5bGFuLCBQLiBSLjwvYXV0aG9yPjxhdXRob3I+UGFzY3VhbCwgTS48L2F1dGhvcj48YXV0aG9y

PnZhbiBEZWxkZW4sIEMuPC9hdXRob3I+PGF1dGhvcj5Cb2NodWQsIFAuIFkuPC9hdXRob3I+PGF1

dGhvcj5Td2lzcyBUcmFuc3BsYW50IENvaG9ydCwgU3R1ZHk8L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5JbmZlY3Rpb3VzIERpc2Vhc2VzIFNlcnZpY2UsIFVu

aXZlcnNpdHkgSG9zcGl0YWwgYW5kIFVuaXZlcnNpdHkgb2YgTGF1c2FubmUuJiN4RDtTZXJ2aWNl

IG9mIFRyYW5zcGxhbnRhdGlvbiBhbmQgU2VydmljZSBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzLCBV

bml2ZXJzaXR5IEhvc3BpdGFscyBvZiBHZW5ldmEuJiN4RDtJbmZlY3Rpb3VzIERpc2Vhc2VzIFNl

cnZpY2UsIFVuaXZlcnNpdHkgSG9zcGl0YWwgYW5kIFVuaXZlcnNpdHkgb2YgTGF1c2FubmUgVHJh

bnNwbGFudGF0aW9uIENlbnRlciwgRGVwYXJ0bWVudCBvZiBTdXJnZXJ5LiYjeEQ7SW5zdGl0dXRl

IG9mIFNvY2lhbCBhbmQgUHJldmVudGl2ZSBNZWRpY2luZSwgVW5pdmVyc2l0eSBIb3NwaXRhbCBh

bmQgVW5pdmVyc2l0eSBvZiBMYXVzYW5uZSBTd2lzcyBJbnN0aXR1dGUgb2YgQmlvaW5mb3JtYXRp

Y3MsIExhdXNhbm5lLiYjeEQ7RGl2aXNpb24gb2YgSW5mZWN0aW91cyBEaXNlYXNlcyBhbmQgSG9z

cGl0YWwgRXBpZGVtaW9sb2d5LCBVbml2ZXJzaXR5IENoaWxkcmVuJmFwb3M7cyBIb3NwaXRhbCBa

dXJpY2guJiN4RDtEaXZpc2lvbiBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzIGFuZCBIb3NwaXRhbCBF

cGlkZW1pb2xvZ3ksIENhbnRvbmFsIEhvc3BpdGFsIFN0IEdhbGxlbi4mI3hEO0RlcGFydG1lbnQg

b2YgSW5mZWN0aW91cyBEaXNlYXNlcywgSW5zZWxzcGl0YWwsIEJlcm4gVW5pdmVyc2l0eSBIb3Nw

aXRhbCBhbmQgVW5pdmVyc2l0eSBvZiBCZXJuLiYjeEQ7RGVwYXJ0bWVudCBvZiBJbmZlY3Rpb3Vz

IERpc2Vhc2VzLCBJbnNlbHNwaXRhbCwgQmVybiBVbml2ZXJzaXR5IEhvc3BpdGFsIGFuZCBVbml2

ZXJzaXR5IG9mIEJlcm4gRGVwYXJ0bWVudHMgb2YgSW50ZXJuYWwgTWVkaWNpbmUgYW5kIEluZmVj

dGlvdXMgRGlzZWFzZSwgQ2xpbmljYSBMdWdhbmVzZSwgTHVnYW5vLiYjeEQ7RGl2aXNpb24gb2Yg

SW5mZWN0aW91cyBEaXNlYXNlcyBhbmQgSG9zcGl0YWwgRXBpZGVtaW9sb2d5LCBVbml2ZXJzaXR5

IEhvc3BpdGFsIG9mIEJhc2VsLiYjeEQ7RGl2aXNpb24gb2YgSW5mZWN0aW91cyBEaXNlYXNlcyBh

bmQgSG9zcGl0YWwgRXBpZGVtaW9sb2d5LCBVbml2ZXJzaXR5IEhvc3BpdGFsIFp1cmljaC4mI3hE

O0luZmVjdGlvdXMgRGlzZWFzZXMgU2VydmljZSwgVW5pdmVyc2l0eSBIb3NwaXRhbCBhbmQgVW5p

dmVyc2l0eSBvZiBMYXVzYW5uZSBJbnN0aXR1dGUgb2YgTWljcm9iaW9sb2d5LCBVbml2ZXJzaXR5

IEhvc3BpdGFsIGFuZCBVbml2ZXJzaXR5IG9mIExhdXNhbm5lLCBTd2l0emVybGFuZC4mI3hEO1Ry

YW5zcGxhbnRhdGlvbiBDZW50ZXIsIERlcGFydG1lbnQgb2YgU3VyZ2VyeS48L2F1dGgtYWRkcmVz

cz48dGl0bGVzPjx0aXRsZT5QVFgzIFBvbHltb3JwaGlzbXMgYW5kIEludmFzaXZlIE1vbGQgSW5m

ZWN0aW9ucyBBZnRlciBTb2xpZCBPcmdhbiBUcmFuc3BsYW50PC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkNsaW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFi

YnItMT5DbGluLiBJbmZlY3QuIERpcy48L2FiYnItMT48YWJici0yPkNsaW4gSW5mZWN0IERpczwv

YWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+NjE5LTIyPC9wYWdlcz48dm9sdW1lPjYxPC92b2x1

bWU+PG51bWJlcj40PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPlB0eDM8L2tleXdvcmQ+PGtl

eXdvcmQ+U25wPC9rZXl3b3JkPjxrZXl3b3JkPmdlbmV0aWMgc3VzY2VwdGliaWxpdHk8L2tleXdv

cmQ+PGtleXdvcmQ+aW5uYXRlIGltbXVuaXR5PC9rZXl3b3JkPjxrZXl3b3JkPnNvbGlkIG9yZ2Fu

IHRyYW5zcGxhbnQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48

cHViLWRhdGVzPjxkYXRlPkF1ZyAxNTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1

MzctNjU5MSAoRWxlY3Ryb25pYykmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MjU5NzcyNjg8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjU5NzcyNjg8L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvY2lkL2NpdjM4

NjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+

V29qdG93aWN6PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVjTnVtPjYzNjwvUmVjTnVtPjxy

ZWNvcmQ+PHJlYy1udW1iZXI+NjM2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3Rh

bXA9IjE0MzkzMTM5ODkiPjYzNjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK

b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo

b3I+V29qdG93aWN6LCBBLjwvYXV0aG9yPjxhdXRob3I+R3Jlc25pZ3QsIE0uIFMuPC9hdXRob3I+

PGF1dGhvcj5MZWNvbXB0ZSwgVC48L2F1dGhvcj48YXV0aG9yPkJpYmVydCwgUy48L2F1dGhvcj48

YXV0aG9yPk1hbnVlbCwgTy48L2F1dGhvcj48YXV0aG9yPkpvb3N0ZW4sIEwuIEEuPC9hdXRob3I+

PGF1dGhvcj5SdWVnZXIsIFMuPC9hdXRob3I+PGF1dGhvcj5CZXJnZXIsIEMuPC9hdXRob3I+PGF1

dGhvcj5Cb2dnaWFuLCBLLjwvYXV0aG9yPjxhdXRob3I+Q3VzaW5pLCBBLjwvYXV0aG9yPjxhdXRo

b3I+R2Fyem9uaSwgQy48L2F1dGhvcj48YXV0aG9yPkhpcnNjaCwgSC4gSC48L2F1dGhvcj48YXV0

aG9yPldlaXNzZXIsIE0uPC9hdXRob3I+PGF1dGhvcj5NdWVsbGVyLCBOLiBKLjwvYXV0aG9yPjxh

dXRob3I+TWV5bGFuLCBQLiBSLjwvYXV0aG9yPjxhdXRob3I+U3RlaWdlciwgSi48L2F1dGhvcj48

YXV0aG9yPkt1dGFsaWssIFouPC9hdXRob3I+PGF1dGhvcj5QYXNjdWFsLCBNLjwvYXV0aG9yPjxh

dXRob3I+dmFuIERlbGRlbiwgQy48L2F1dGhvcj48YXV0aG9yPnZhbiBkZSBWZWVyZG9uaywgRi4g

TC48L2F1dGhvcj48YXV0aG9yPkJvY2h1ZCwgUC4gWS48L2F1dGhvcj48YXV0aG9yPlN3aXNzIFRy

YW5zcGxhbnQgQ29ob3J0LCBTdHVkeTwvYXV0aG9yPjxhdXRob3I+U3dpc3MgVHJhbnNwbGFudCBD

b2hvcnQgU3R1ZHksIFN0Y3M8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt

YWRkcmVzcz5JbmZlY3Rpb3VzIERpc2Vhc2VzIFNlcnZpY2UuJiN4RDtEZXBhcnRtZW50IG9mIElu

dGVybmFsIE1lZGljaW5lLCBSYWRib3VkIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIsIE5pam1l

Z2VuLCBUaGUgTmV0aGVybGFuZHMuJiN4RDtTZXJ2aWNlIG9mIFRyYW5zcGxhbnRhdGlvbiBTZXJ2

aWNlIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIFVuaXZlcnNpdHkgSG9zcGl0YWxzIG9mIEdlbmV2

YS4mI3hEO0luZmVjdGlvdXMgRGlzZWFzZXMgU2VydmljZSBUcmFuc3BsYW50YXRpb24gQ2VudGVy

LCBEZXBhcnRtZW50IG9mIFN1cmdlcnkuJiN4RDtJbnN0aXR1dGUgb2YgU29jaWFsIGFuZCBQcmV2

ZW50aXZlIE1lZGljaW5lIFN3aXNzIEluc3RpdHV0ZSBvZiBCaW9pbmZvcm1hdGljcywgTGF1c2Fu

bmUuJiN4RDtEaXZpc2lvbiBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzIGFuZCBIb3NwaXRhbCBFcGlk

ZW1pb2xvZ3ksIFVuaXZlcnNpdHkgQ2hpbGRyZW4mYXBvcztzIEhvc3BpdGFsIFp1cmljaC4mI3hE

O0RpdmlzaW9uIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMgYW5kIEhvc3BpdGFsIEVwaWRlbWlvbG9n

eSwgQ2FudG9uYWwgSG9zcGl0YWwgU3QuIEdhbGxlbi4mI3hEO0RlcGFydG1lbnQgb2YgSW5mZWN0

aW91cyBEaXNlYXNlcywgSW5zZWxzcGl0YWwsIEJlcm4gVW5pdmVyc2l0eSBIb3NwaXRhbCBhbmQg

VW5pdmVyc2l0eSBvZiBCZXJuLiYjeEQ7RGVwYXJ0bWVudCBvZiBJbmZlY3Rpb3VzIERpc2Vhc2Vz

LCBJbnNlbHNwaXRhbCwgQmVybiBVbml2ZXJzaXR5IEhvc3BpdGFsIGFuZCBVbml2ZXJzaXR5IG9m

IEJlcm4gRGVwYXJ0bWVudCBvZiBJbnRlcm5hbCBNZWRpY2luZS4mI3hEO0RpdmlzaW9uIG9mIElu

ZmVjdGlvdXMgRGlzZWFzZXMgYW5kIEhvc3BpdGFsIEVwaWRlbWlvbG9neS4mI3hEO0RpdmlzaW9u

IG9mIEluZmVjdGlvdXMgRGlzZWFzZXMgYW5kIEhvc3BpdGFsIEVwaWRlbWlvbG9neSwgVW5pdmVy

c2l0eSBIb3NwaXRhbCBadXJpY2guJiN4RDtJbmZlY3Rpb3VzIERpc2Vhc2VzIFNlcnZpY2UgSW5z

dGl0dXRlIG9mIE1pY3JvYmlvbG9neSwgVW5pdmVyc2l0eSBIb3NwaXRhbCBhbmQgVW5pdmVyc2l0

eSBvZiBMYXVzYW5uZS4mI3hEO0NsaW5pYyBmb3IgVHJhbnNwbGFudGF0aW9uIEltbXVub2xvZ3kg

YW5kIE5lcGhyb2xvZ3ksIFVuaXZlcnNpdHkgSG9zcGl0YWwgb2YgQmFzZWwsIFN3aXR6ZXJsYW5k

LiYjeEQ7SW5mZWN0aW91cyBEaXNlYXNlcyBTZXJ2aWNlIFN3aXNzIEluc3RpdHV0ZSBvZiBCaW9p

bmZvcm1hdGljcywgTGF1c2FubmUuJiN4RDtUcmFuc3BsYW50YXRpb24gQ2VudGVyLCBEZXBhcnRt

ZW50IG9mIFN1cmdlcnkuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+SUwxQiBhbmQgREVG

QjEgUG9seW1vcnBoaXNtcyBJbmNyZWFzZSBTdXNjZXB0aWJpbGl0eSB0byBJbnZhc2l2ZSBNb2xk

IEluZmVjdGlvbiBBZnRlciBTb2xpZC1PcmdhbiBUcmFuc3BsYW50YXRpb248L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+SiBJbmZlY3QgRGlzPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRp

dGxlPjxhYmJyLTE+Si4gSW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5KIEluZmVjdCBEaXM8

L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjE2NDYtNTc8L3BhZ2VzPjx2b2x1bWU+MjExPC92

b2x1bWU+PG51bWJlcj4xMDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29y

ZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkNvaG9ydCBTdHVkaWVzPC9rZXl3b3Jk

PjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5GdW5naS8qaXNvbGF0aW9uICZhbXA7

IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5HZW5ldGljIEFzc29jaWF0aW9uIFN0dWRp

ZXM8L2tleXdvcmQ+PGtleXdvcmQ+KkdlbmV0aWMgUHJlZGlzcG9zaXRpb24gdG8gRGlzZWFzZTwv

a2V5d29yZD48a2V5d29yZD5HZW5vdHlwZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdv

cmQ+PGtleXdvcmQ+SW50ZXJsZXVraW4tMWJldGEvKmdlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3Jk

Pk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXlj

b3Nlcy8qZXBpZGVtaW9sb2d5L2dlbmV0aWNzL2ltbXVub2xvZ3kvbWljcm9iaW9sb2d5PC9rZXl3

b3JkPjxrZXl3b3JkPk9yZ2FuIFRyYW5zcGxhbnRhdGlvbi8qYWR2ZXJzZSBlZmZlY3RzPC9rZXl3

b3JkPjxrZXl3b3JkPipQb2x5bW9ycGhpc20sIFNpbmdsZSBOdWNsZW90aWRlPC9rZXl3b3JkPjxr

ZXl3b3JkPlRyYW5zcGxhbnQgUmVjaXBpZW50czwva2V5d29yZD48a2V5d29yZD5iZXRhLURlZmVu

c2lucy8qZ2VuZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+YXNwZXJnaWxsb3Npczwva2V5d29yZD48

a2V5d29yZD5nZW5ldGljIHN1c2NlcHRpYmlsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPmlubmF0ZSBp

bW11bml0eTwva2V5d29yZD48a2V5d29yZD5pbnRlcmxldWtpbi0xIGJldGE8L2tleXdvcmQ+PGtl

eXdvcmQ+aW52YXNpdmUgbW9sZCBpbmZlY3Rpb25zPC9rZXl3b3JkPjxrZXl3b3JkPnNpbmdsZSBu

dWNsZW90aWRlIHBvbHltb3JwaGlzbTwva2V5d29yZD48a2V5d29yZD5zb2xpZCBvcmdhbiB0cmFu

c3BsYW50PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1k

YXRlcz48ZGF0ZT5NYXkgMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY2

MTMgKEVsZWN0cm9uaWMpJiN4RDswMDIyLTE4OTkgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24t

bnVtPjI1Mzk4NDU2PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRw

Oi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI1Mzk4NDU2PC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkzL2luZmRpcy9qaXU2MzY8

L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA [38, 39]. Lung transplant recipients have the highest risk of invasive aspergillosis PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXBwYXM8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS

ZWNOdW0+Njc0PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls0MC00Ml08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+Njc0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9

IjE0NDQ0MDgyODgiPjY3NDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

UGFwcGFzLCBQLiBHLjwvYXV0aG9yPjxhdXRob3I+QWxleGFuZGVyLCBCLiBELjwvYXV0aG9yPjxh

dXRob3I+QW5kZXMsIEQuIFIuPC9hdXRob3I+PGF1dGhvcj5IYWRsZXksIFMuPC9hdXRob3I+PGF1

dGhvcj5LYXVmZm1hbiwgQy4gQS48L2F1dGhvcj48YXV0aG9yPkZyZWlmZWxkLCBBLjwvYXV0aG9y

PjxhdXRob3I+QW5haXNzaWUsIEUuIEouPC9hdXRob3I+PGF1dGhvcj5CcnVtYmxlLCBMLiBNLjwv

YXV0aG9yPjxhdXRob3I+SGVyd2FsZHQsIEwuPC9hdXRob3I+PGF1dGhvcj5JdG8sIEouPC9hdXRo

b3I+PGF1dGhvcj5Lb250b3lpYW5uaXMsIEQuIFAuPC9hdXRob3I+PGF1dGhvcj5MeW9uLCBHLiBN

LjwvYXV0aG9yPjxhdXRob3I+TWFyciwgSy4gQS48L2F1dGhvcj48YXV0aG9yPk1vcnJpc29uLCBW

LiBBLjwvYXV0aG9yPjxhdXRob3I+UGFyaywgQi4gSi48L2F1dGhvcj48YXV0aG9yPlBhdHRlcnNv

biwgVC4gRi48L2F1dGhvcj48YXV0aG9yPlBlcmwsIFQuIE0uPC9hdXRob3I+PGF1dGhvcj5Pc3Rl

ciwgUi4gQS48L2F1dGhvcj48YXV0aG9yPlNjaHVzdGVyLCBNLiBHLjwvYXV0aG9yPjxhdXRob3I+

V2Fsa2VyLCBSLjwvYXV0aG9yPjxhdXRob3I+V2Fsc2gsIFQuIEouPC9hdXRob3I+PGF1dGhvcj5X

YW5uZW11ZWhsZXIsIEsuIEEuPC9hdXRob3I+PGF1dGhvcj5DaGlsbGVyLCBULiBNLjwvYXV0aG9y

PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlzaW9uIG9mIEluZmVj

dGlvdXMgRGlzZWFzZXMsIERlcGFydG1lbnQgb2YgTWVkaWNpbmUsIFVuaXZlcnNpdHkgb2YgQWxh

YmFtYSBhdCBCaXJtaW5naGFtIE1lZGljYWwgQ2VudGVyLCBCaXJtaW5naGFtLCBBbGFiYW1hIDM1

Mjk0LTAwMDYsIFVTQS4gcGFwcGFzQHVhYi5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRs

ZT5JbnZhc2l2ZSBmdW5nYWwgaW5mZWN0aW9ucyBhbW9uZyBvcmdhbiB0cmFuc3BsYW50IHJlY2lw

aWVudHM6IHJlc3VsdHMgb2YgdGhlIFRyYW5zcGxhbnQtQXNzb2NpYXRlZCBJbmZlY3Rpb24gU3Vy

dmVpbGxhbmNlIE5ldHdvcmsgKFRSQU5TTkVUKTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGlu

IEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2xp

bi4gSW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5DbGluIEluZmVjdCBEaXM8L2FiYnItMj48

L3BlcmlvZGljYWw+PHBhZ2VzPjExMDEtMTE8L3BhZ2VzPjx2b2x1bWU+NTA8L3ZvbHVtZT48bnVt

YmVyPjg8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5

d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQs

IDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNo

aWxkLCBQcmVzY2hvb2w8L2tleXdvcmQ+PGtleXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdvcmQ+

PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29y

ZD4qSW1tdW5vY29tcHJvbWlzZWQgSG9zdDwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8L2tl

eXdvcmQ+PGtleXdvcmQ+SW5mYW50PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtl

eXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXljb3Nlcy8qZXBpZGVtaW9sb2d5

PC9rZXl3b3JkPjxrZXl3b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+

KlNlbnRpbmVsIFN1cnZlaWxsYW5jZTwva2V5d29yZD48a2V5d29yZD5UcmFuc3BsYW50cy8qYWR2

ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPlVuaXRlZCBTdGF0ZXMvZXBpZGVtaW9sb2d5

PC9rZXl3b3JkPjxrZXl3b3JkPllvdW5nIEFkdWx0PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVz

Pjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHIgMTU8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU4LTQ4MzggKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMjE4ODc2PC9hY2Nlc3Npb24tbnVtPjx1cmxz

PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIw

MjE4ODc2PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51

bT4xMC4xMDg2LzY1MTI2MjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRl

PjxDaXRlPjxBdXRob3I+RG9saWdhbHNraTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051

bT4yNjAyMTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjYwMjE8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5

MHB3MmR4enB0ZXAiPjI2MDIxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5Eb2xpZ2Fsc2tpLCBDLiBULjwvYXV0aG9yPjxhdXRob3I+QmVuZWRpY3QsIEsuPC9hdXRob3I+

PGF1dGhvcj5DbGV2ZWxhbmQsIEEuIEEuPC9hdXRob3I+PGF1dGhvcj5QYXJrLCBCLjwvYXV0aG9y

PjxhdXRob3I+RGVyYWRvLCBHLjwvYXV0aG9yPjxhdXRob3I+UGFwcGFzLCBQLiBHLjwvYXV0aG9y

PjxhdXRob3I+QmFkZGxleSwgSi4gVy48L2F1dGhvcj48YXV0aG9yPlphYXMsIEQuIFcuPC9hdXRo

b3I+PGF1dGhvcj5IYXJyaXMsIE0uIFQuPC9hdXRob3I+PGF1dGhvcj5BbGV4YW5kZXIsIEIuIEQu

PC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVu

dCBvZiBQaGFybWFjeSwgVGFtcGEgR2VuZXJhbCBIb3NwaXRhbCwgVGFtcGEsIEZMLjwvYXV0aC1h

ZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVwaWRlbWlvbG9neSBvZiBpbnZhc2l2ZSBtb2xkIGluZmVj

dGlvbnMgaW4gbHVuZyB0cmFuc3BsYW50IHJlY2lwaWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QW0gSiBUcmFuc3BsYW50PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5BbWVyaWNhbiBq

b3VybmFsIG9mIHRyYW5zcGxhbnRhdGlvbiA6IG9mZmljaWFsIGpvdXJuYWwgb2YgdGhlIEFtZXJp

Y2FuIFNvY2lldHkgb2YgVHJhbnNwbGFudGF0aW9uIGFuZCB0aGUgQW1lcmljYW4gU29jaWV0eSBv

ZiBUcmFuc3BsYW50IFN1cmdlb25zPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+QW0gSiBUcmFuc3BsYW50PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+

MTMyOC0zMzwvcGFnZXM+PHZvbHVtZT4xNDwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxlZGl0

aW9uPjIwMTQvMDQvMTU8L2VkaXRpb24+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRl

cz48ZGF0ZT5KdW48L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNjAwLTYxNDMgKEVs

ZWN0cm9uaWMpJiN4RDsxNjAwLTYxMzUgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0

NzI2MDIwPC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkgu

LCBFeHRyYW11cmFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBVLlMuIEdvdiZhcG9zO3QsIFAuSC5T

Ljwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzI0NzI2MDIwPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0

b20yPjQxNTg3MTI8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMTEvYWp0

LjEyNjkxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48

L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5OZW9meXRvczwvQXV0aG9yPjxZZWFyPjIwMTA8

L1llYXI+PFJlY051bT4yNTkxOTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjU5MTk8L3Jl

Yy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBh

dmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI1OTE5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10

eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1

dGhvcnM+PGF1dGhvcj5OZW9meXRvcywgRC48L2F1dGhvcj48YXV0aG9yPkZpc2htYW4sIEouIEEu

PC9hdXRob3I+PGF1dGhvcj5Ib3JuLCBELjwvYXV0aG9yPjxhdXRob3I+QW5haXNzaWUsIEUuPC9h

dXRob3I+PGF1dGhvcj5DaGFuZywgQy4gSC48L2F1dGhvcj48YXV0aG9yPk9seWFlaSwgQS48L2F1

dGhvcj48YXV0aG9yPlBmYWxsZXIsIE0uPC9hdXRob3I+PGF1dGhvcj5TdGVpbmJhY2gsIFcuIEou

PC9hdXRob3I+PGF1dGhvcj5XZWJzdGVyLCBLLiBNLjwvYXV0aG9yPjxhdXRob3I+TWFyciwgSy4g

QS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5TY2hvb2wg

b2YgTWVkaWNpbmUsIERpdmlzaW9uIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIFRoZSBKb2hucyBI

b3BraW5zIFVuaXZlcnNpdHksIEJhbHRpbW9yZSwgTWFyeWxhbmQgMjEyMDUsIFVTQS4gZG5lb2Z5

dDFAamhtaS5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5FcGlkZW1pb2xvZ3kgYW5k

IG91dGNvbWUgb2YgaW52YXNpdmUgZnVuZ2FsIGluZmVjdGlvbnMgaW4gc29saWQgb3JnYW4gdHJh

bnNwbGFudCByZWNpcGllbnRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlRyYW5zcGwgSW5mZWN0

IERpczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+VHJhbnNwbGFudCBpbmZlY3Rpb3VzIGRp

c2Vhc2UgOiBhbiBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBUcmFuc3BsYW50YXRpb24gU29jaWV0

eTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlRyYW5zcGwgSW5m

ZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjIyMC05PC9wYWdlcz48dm9s

dW1lPjEyPC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGVkaXRpb24+MjAxMC8wMi8wMjwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5

d29yZD48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy9hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3Nh

Z2UvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvZHJ1ZyB0

aGVyYXB5L2VwaWRlbWlvbG9neS9taWNyb2Jpb2xvZ3kvbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3

b3JkPkFzcGVyZ2lsbHVzL2RydWcgZWZmZWN0cy9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9u

PC9rZXl3b3JkPjxrZXl3b3JkPkNhbmRpZGEvZHJ1ZyBlZmZlY3RzL2lzb2xhdGlvbiAmYW1wOyBw

dXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+Q2FuZGlkaWFzaXMvZHJ1ZyB0aGVyYXB5L2Vw

aWRlbWlvbG9neS9taWNyb2Jpb2xvZ3kvbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkNyeXB0

b2NvY2Nvc2lzL2RydWcgdGhlcmFweS9lcGlkZW1pb2xvZ3kvbWljcm9iaW9sb2d5L21vcnRhbGl0

eTwva2V5d29yZD48a2V5d29yZD5DcnlwdG9jb2NjdXMvZHJ1ZyBlZmZlY3RzL2lzb2xhdGlvbiAm

YW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3

b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRs

ZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk15Y29zZXMvZHJ1ZyB0aGVyYXB5LyplcGlkZW1pb2xv

Z3kvbWljcm9iaW9sb2d5Lyptb3J0YWxpdHk8L2tleXdvcmQ+PGtleXdvcmQ+T3JnYW4gVHJhbnNw

bGFudGF0aW9uLyphZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+U3Vydml2YWwgUmF0

ZTwva2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRt

ZW50IE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlcy9lcGlkZW1pb2xvZ3k8

L2tleXdvcmQ+PGtleXdvcmQ+WW91bmcgQWR1bHQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAxMDwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48

L2RhdGVzPjxpc2JuPjEzOTktMzA2MiAoRWxlY3Ryb25pYykmI3hEOzEzOTgtMjI3MyAoTGlua2lu

Zyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjAxMTM0NTk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjAxMTM0

NTk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw

LjExMTEvai4xMzk5LTMwNjIuMjAxMC4wMDQ5Mi54PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48

bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXBwYXM8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS

ZWNOdW0+Njc0PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls0MC00Ml08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+Njc0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9

IjE0NDQ0MDgyODgiPjY3NDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

UGFwcGFzLCBQLiBHLjwvYXV0aG9yPjxhdXRob3I+QWxleGFuZGVyLCBCLiBELjwvYXV0aG9yPjxh

dXRob3I+QW5kZXMsIEQuIFIuPC9hdXRob3I+PGF1dGhvcj5IYWRsZXksIFMuPC9hdXRob3I+PGF1

dGhvcj5LYXVmZm1hbiwgQy4gQS48L2F1dGhvcj48YXV0aG9yPkZyZWlmZWxkLCBBLjwvYXV0aG9y

PjxhdXRob3I+QW5haXNzaWUsIEUuIEouPC9hdXRob3I+PGF1dGhvcj5CcnVtYmxlLCBMLiBNLjwv

YXV0aG9yPjxhdXRob3I+SGVyd2FsZHQsIEwuPC9hdXRob3I+PGF1dGhvcj5JdG8sIEouPC9hdXRo

b3I+PGF1dGhvcj5Lb250b3lpYW5uaXMsIEQuIFAuPC9hdXRob3I+PGF1dGhvcj5MeW9uLCBHLiBN

LjwvYXV0aG9yPjxhdXRob3I+TWFyciwgSy4gQS48L2F1dGhvcj48YXV0aG9yPk1vcnJpc29uLCBW

LiBBLjwvYXV0aG9yPjxhdXRob3I+UGFyaywgQi4gSi48L2F1dGhvcj48YXV0aG9yPlBhdHRlcnNv

biwgVC4gRi48L2F1dGhvcj48YXV0aG9yPlBlcmwsIFQuIE0uPC9hdXRob3I+PGF1dGhvcj5Pc3Rl

ciwgUi4gQS48L2F1dGhvcj48YXV0aG9yPlNjaHVzdGVyLCBNLiBHLjwvYXV0aG9yPjxhdXRob3I+

V2Fsa2VyLCBSLjwvYXV0aG9yPjxhdXRob3I+V2Fsc2gsIFQuIEouPC9hdXRob3I+PGF1dGhvcj5X

YW5uZW11ZWhsZXIsIEsuIEEuPC9hdXRob3I+PGF1dGhvcj5DaGlsbGVyLCBULiBNLjwvYXV0aG9y

PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlzaW9uIG9mIEluZmVj

dGlvdXMgRGlzZWFzZXMsIERlcGFydG1lbnQgb2YgTWVkaWNpbmUsIFVuaXZlcnNpdHkgb2YgQWxh

YmFtYSBhdCBCaXJtaW5naGFtIE1lZGljYWwgQ2VudGVyLCBCaXJtaW5naGFtLCBBbGFiYW1hIDM1

Mjk0LTAwMDYsIFVTQS4gcGFwcGFzQHVhYi5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRs

ZT5JbnZhc2l2ZSBmdW5nYWwgaW5mZWN0aW9ucyBhbW9uZyBvcmdhbiB0cmFuc3BsYW50IHJlY2lw

aWVudHM6IHJlc3VsdHMgb2YgdGhlIFRyYW5zcGxhbnQtQXNzb2NpYXRlZCBJbmZlY3Rpb24gU3Vy

dmVpbGxhbmNlIE5ldHdvcmsgKFRSQU5TTkVUKTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGlu

IEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2xp

bi4gSW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5DbGluIEluZmVjdCBEaXM8L2FiYnItMj48

L3BlcmlvZGljYWw+PHBhZ2VzPjExMDEtMTE8L3BhZ2VzPjx2b2x1bWU+NTA8L3ZvbHVtZT48bnVt

YmVyPjg8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5

d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQs

IDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNo

aWxkLCBQcmVzY2hvb2w8L2tleXdvcmQ+PGtleXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdvcmQ+

PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29y

ZD4qSW1tdW5vY29tcHJvbWlzZWQgSG9zdDwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8L2tl

eXdvcmQ+PGtleXdvcmQ+SW5mYW50PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtl

eXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXljb3Nlcy8qZXBpZGVtaW9sb2d5

PC9rZXl3b3JkPjxrZXl3b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+

KlNlbnRpbmVsIFN1cnZlaWxsYW5jZTwva2V5d29yZD48a2V5d29yZD5UcmFuc3BsYW50cy8qYWR2

ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPlVuaXRlZCBTdGF0ZXMvZXBpZGVtaW9sb2d5

PC9rZXl3b3JkPjxrZXl3b3JkPllvdW5nIEFkdWx0PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVz

Pjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHIgMTU8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU4LTQ4MzggKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMjE4ODc2PC9hY2Nlc3Npb24tbnVtPjx1cmxz

PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIw

MjE4ODc2PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51

bT4xMC4xMDg2LzY1MTI2MjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRl

PjxDaXRlPjxBdXRob3I+RG9saWdhbHNraTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051

bT4yNjAyMTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjYwMjE8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5

MHB3MmR4enB0ZXAiPjI2MDIxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5Eb2xpZ2Fsc2tpLCBDLiBULjwvYXV0aG9yPjxhdXRob3I+QmVuZWRpY3QsIEsuPC9hdXRob3I+

PGF1dGhvcj5DbGV2ZWxhbmQsIEEuIEEuPC9hdXRob3I+PGF1dGhvcj5QYXJrLCBCLjwvYXV0aG9y

PjxhdXRob3I+RGVyYWRvLCBHLjwvYXV0aG9yPjxhdXRob3I+UGFwcGFzLCBQLiBHLjwvYXV0aG9y

PjxhdXRob3I+QmFkZGxleSwgSi4gVy48L2F1dGhvcj48YXV0aG9yPlphYXMsIEQuIFcuPC9hdXRo

b3I+PGF1dGhvcj5IYXJyaXMsIE0uIFQuPC9hdXRob3I+PGF1dGhvcj5BbGV4YW5kZXIsIEIuIEQu

PC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVu

dCBvZiBQaGFybWFjeSwgVGFtcGEgR2VuZXJhbCBIb3NwaXRhbCwgVGFtcGEsIEZMLjwvYXV0aC1h

ZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVwaWRlbWlvbG9neSBvZiBpbnZhc2l2ZSBtb2xkIGluZmVj

dGlvbnMgaW4gbHVuZyB0cmFuc3BsYW50IHJlY2lwaWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QW0gSiBUcmFuc3BsYW50PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5BbWVyaWNhbiBq

b3VybmFsIG9mIHRyYW5zcGxhbnRhdGlvbiA6IG9mZmljaWFsIGpvdXJuYWwgb2YgdGhlIEFtZXJp

Y2FuIFNvY2lldHkgb2YgVHJhbnNwbGFudGF0aW9uIGFuZCB0aGUgQW1lcmljYW4gU29jaWV0eSBv

ZiBUcmFuc3BsYW50IFN1cmdlb25zPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+QW0gSiBUcmFuc3BsYW50PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+

MTMyOC0zMzwvcGFnZXM+PHZvbHVtZT4xNDwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxlZGl0

aW9uPjIwMTQvMDQvMTU8L2VkaXRpb24+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRl

cz48ZGF0ZT5KdW48L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNjAwLTYxNDMgKEVs

ZWN0cm9uaWMpJiN4RDsxNjAwLTYxMzUgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0

NzI2MDIwPC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkgu

LCBFeHRyYW11cmFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBVLlMuIEdvdiZhcG9zO3QsIFAuSC5T

Ljwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzI0NzI2MDIwPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0

b20yPjQxNTg3MTI8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMTEvYWp0

LjEyNjkxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48

L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5OZW9meXRvczwvQXV0aG9yPjxZZWFyPjIwMTA8

L1llYXI+PFJlY051bT4yNTkxOTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjU5MTk8L3Jl

Yy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBh

dmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI1OTE5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10

eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1

dGhvcnM+PGF1dGhvcj5OZW9meXRvcywgRC48L2F1dGhvcj48YXV0aG9yPkZpc2htYW4sIEouIEEu

PC9hdXRob3I+PGF1dGhvcj5Ib3JuLCBELjwvYXV0aG9yPjxhdXRob3I+QW5haXNzaWUsIEUuPC9h

dXRob3I+PGF1dGhvcj5DaGFuZywgQy4gSC48L2F1dGhvcj48YXV0aG9yPk9seWFlaSwgQS48L2F1

dGhvcj48YXV0aG9yPlBmYWxsZXIsIE0uPC9hdXRob3I+PGF1dGhvcj5TdGVpbmJhY2gsIFcuIEou

PC9hdXRob3I+PGF1dGhvcj5XZWJzdGVyLCBLLiBNLjwvYXV0aG9yPjxhdXRob3I+TWFyciwgSy4g

QS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5TY2hvb2wg

b2YgTWVkaWNpbmUsIERpdmlzaW9uIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIFRoZSBKb2hucyBI

b3BraW5zIFVuaXZlcnNpdHksIEJhbHRpbW9yZSwgTWFyeWxhbmQgMjEyMDUsIFVTQS4gZG5lb2Z5

dDFAamhtaS5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5FcGlkZW1pb2xvZ3kgYW5k

IG91dGNvbWUgb2YgaW52YXNpdmUgZnVuZ2FsIGluZmVjdGlvbnMgaW4gc29saWQgb3JnYW4gdHJh

bnNwbGFudCByZWNpcGllbnRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlRyYW5zcGwgSW5mZWN0

IERpczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+VHJhbnNwbGFudCBpbmZlY3Rpb3VzIGRp

c2Vhc2UgOiBhbiBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBUcmFuc3BsYW50YXRpb24gU29jaWV0

eTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlRyYW5zcGwgSW5m

ZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjIyMC05PC9wYWdlcz48dm9s

dW1lPjEyPC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGVkaXRpb24+MjAxMC8wMi8wMjwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5

d29yZD48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy9hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3Nh

Z2UvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvZHJ1ZyB0

aGVyYXB5L2VwaWRlbWlvbG9neS9taWNyb2Jpb2xvZ3kvbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3

b3JkPkFzcGVyZ2lsbHVzL2RydWcgZWZmZWN0cy9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9u

PC9rZXl3b3JkPjxrZXl3b3JkPkNhbmRpZGEvZHJ1ZyBlZmZlY3RzL2lzb2xhdGlvbiAmYW1wOyBw

dXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+Q2FuZGlkaWFzaXMvZHJ1ZyB0aGVyYXB5L2Vw

aWRlbWlvbG9neS9taWNyb2Jpb2xvZ3kvbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkNyeXB0

b2NvY2Nvc2lzL2RydWcgdGhlcmFweS9lcGlkZW1pb2xvZ3kvbWljcm9iaW9sb2d5L21vcnRhbGl0

eTwva2V5d29yZD48a2V5d29yZD5DcnlwdG9jb2NjdXMvZHJ1ZyBlZmZlY3RzL2lzb2xhdGlvbiAm

YW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3

b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRs

ZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk15Y29zZXMvZHJ1ZyB0aGVyYXB5LyplcGlkZW1pb2xv

Z3kvbWljcm9iaW9sb2d5Lyptb3J0YWxpdHk8L2tleXdvcmQ+PGtleXdvcmQ+T3JnYW4gVHJhbnNw

bGFudGF0aW9uLyphZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+U3Vydml2YWwgUmF0

ZTwva2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRt

ZW50IE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlcy9lcGlkZW1pb2xvZ3k8

L2tleXdvcmQ+PGtleXdvcmQ+WW91bmcgQWR1bHQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAxMDwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48

L2RhdGVzPjxpc2JuPjEzOTktMzA2MiAoRWxlY3Ryb25pYykmI3hEOzEzOTgtMjI3MyAoTGlua2lu

Zyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjAxMTM0NTk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjAxMTM0

NTk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw

LjExMTEvai4xMzk5LTMwNjIuMjAxMC4wMDQ5Mi54PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48

bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [40-42]. In a multicenter surveillance study, approximately one-half of cases of invasive aspergillosis in lung transplant recipients were late-onset, occurring 1 year or more after transplantation ADDIN EN.CITE <EndNote><Cite><Author>Doligalski</Author><Year>2014</Year><RecNum>26021</RecNum><DisplayText>[41]</DisplayText><record><rec-number>26021</rec-number><foreign-keys><key app="EN" db-id="a9a0zdws9s90ave9xrmxtf9h90pw2dxzptep">26021</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Doligalski, C. T.</author><author>Benedict, K.</author><author>Cleveland, A. A.</author><author>Park, B.</author><author>Derado, G.</author><author>Pappas, P. G.</author><author>Baddley, J. W.</author><author>Zaas, D. W.</author><author>Harris, M. T.</author><author>Alexander, B. D.</author></authors></contributors><auth-address>Department of Pharmacy, Tampa General Hospital, Tampa, FL.</auth-address><titles><title>Epidemiology of invasive mold infections in lung transplant recipients</title><secondary-title>Am J Transplant</secondary-title><alt-title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</alt-title></titles><periodical><full-title>Am J Transplant</full-title></periodical><pages>1328-33</pages><volume>14</volume><number>6</number><edition>2014/04/15</edition><dates><year>2014</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1600-6143 (Electronic)&#xD;1600-6135 (Linking)</isbn><accession-num>24726020</accession-num><work-type>Research Support, N.I.H., Extramural&#xD;Research Support, U.S. Gov&apos;t, P.H.S.</work-type><urls><related-urls><url>;[41]. CMV infection is a risk factor for aspergillosis, notably in heart and lung transplant recipients ADDIN EN.CITE <EndNote><Cite><Author>Singh</Author><Year>2013</Year><RecNum>515</RecNum><DisplayText>[43]</DisplayText><record><rec-number>515</rec-number><foreign-keys><key app="EN" db-id="25ws99rfnw2zfmert5rxzapsprpa5wr2efdr" timestamp="1432753735">515</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Singh, N.</author><author>Husain, S.</author><author>A. S. T. Infectious Diseases Community of Practice</author></authors></contributors><auth-address>VA Pittsburgh Healthcare System and University of Pittsburgh, Pittsburgh, PA, USA. nis5@pitt.edu</auth-address><titles><title>Aspergillosis in solid organ transplantation</title><secondary-title>Am J Transplant</secondary-title><alt-title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</alt-title></titles><periodical><full-title>American Journal of Transplantation</full-title><abbr-1>Am. J. Transplant.</abbr-1><abbr-2>Am J Transplant</abbr-2></periodical><pages>228-41</pages><volume>13 Suppl 4</volume><keywords><keyword>Antifungal Agents/therapeutic use</keyword><keyword>*Aspergillosis/diagnosis/drug therapy/epidemiology/prevention &amp; control</keyword><keyword>Humans</keyword><keyword>*Organ Transplantation</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2013</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1600-6143 (Electronic)&#xD;1600-6135 (Linking)</isbn><accession-num>23465016</accession-num><urls><related-urls><url>;[43]. Pre-transplant Aspergillus airway colonization is frequent among cystic fibrosis patients, and increases the risk of post-lung transplant invasive aspergillosis PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MdW9uZzwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

Y051bT4yNjkzNDwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNDRdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjI2OTM0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNjkzNDwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+THVvbmcsIE0uIEwuPC9hdXRob3I+

PGF1dGhvcj5DaGFwYXJybywgQy48L2F1dGhvcj48YXV0aG9yPlN0ZXBoZW5zb24sIEEuPC9hdXRo

b3I+PGF1dGhvcj5Sb3RzdGVpbiwgQy48L2F1dGhvcj48YXV0aG9yPlNpbmdlciwgTC4gRy48L2F1

dGhvcj48YXV0aG9yPldhdGVycywgVi48L2F1dGhvcj48YXV0aG9yPkF6YWQsIFMuPC9hdXRob3I+

PGF1dGhvcj5LZXNoYXZqZWUsIFMuPC9hdXRob3I+PGF1dGhvcj5UdWxsaXMsIEUuPC9hdXRob3I+

PGF1dGhvcj5IdXNhaW4sIFMuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+MSBEaXZpc2lvbiBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzLCBEZXBhcnRtZW50IG9m

IE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIFRvcm9udG8sIFVuaXZlcnNpdHkgSGVhbHRoIE5ldHdv

cmssIFRvcm9udG8sIE9udGFyaW8sIENhbmFkYS4gMiBEaXZpc2lvbiBvZiBSZXNwaXJvbG9neSwg

VG9yb250byBMdW5nIFRyYW5zcGxhbnQgUHJvZ3JhbSwgVW5pdmVyc2l0eSBvZiBUb3JvbnRvLCBV

bml2ZXJzaXR5IEhlYWx0aCBOZXR3b3JrLCBUb3JvbnRvLCBPbnRhcmlvLCBDYW5hZGEuIDMgQWR1

bHQgQ3lzdGljIEZpYnJvc2lzIENlbnRyZSBhbmQgRGVwYXJ0bWVudCBvZiBSZXNwaXJhdG9yeSBN

ZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBUb3JvbnRvLCBTdCBNaWNoYWVsJmFwb3M7cyBIb3NwaXRh

bCwgVG9yb250bywgQ2FuYWRhLiA0IERpdmlzaW9uIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIERl

cGFydG1lbnQgb2YgUGVkaWF0cmljcywgSG9zcGl0YWwgZm9yIFNpY2sgQ2hpbGRyZW4sIFRvcm9u

dG8sIE9udGFyaW8sIENhbmFkYS4gNSBEaXZpc2lvbiBvZiBUaG9yYWNpYyBTdXJnZXJ5LCBUb3Jv

bnRvIEx1bmcgVHJhbnNwbGFudCBQcm9ncmFtLCBVbml2ZXJzaXR5IG9mIFRvcm9udG8sIFVuaXZl

cnNpdHkgSGVhbHRoIE5ldHdvcmssIFRvcm9udG8sIE9udGFyaW8sIENhbmFkYS4gNiBVbml2ZXJz

aXR5IG9mIFRvcm9udG8sIEtlZW5hbiBSZXNlYXJjaCBDZW50cmUgb2YgdGhlIExpIEthIFNoaW5n

IEtub3dsZWRnZSBJbnN0aXR1dGUsIFN0IE1pY2hhZWwmYXBvcztzIEhvc3BpdGFsLCBUb3JvbnRv

LCBDYW5hZGEuIDcgQWRkcmVzcyBjb3JyZXNwb25kZW5jZSB0bzogU2hhaGlkIEh1c2FpbiwgTS5E

LiwgRGl2aXNpb24gb2YgSW5mZWN0aW91cyBEaXNlYXNlcywgRGVwYXJ0bWVudCBvZiBNZWRpY2lu

ZSwgVW5pdmVyc2l0eSBvZiBUb3JvbnRvLCBUb3JvbnRvIEdlbmVyYWwgSG9zcGl0YWwsIE5DU0Is

IDExdGggZmxvb3IsIDExYy0xMjY5LCA1ODUgVW5pdmVyc2l0eSBBdmVudWUsIFRvcm9udG8sIE9O

LCBDYW5hZGEgTTVHIDJOMi48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5QcmV0cmFuc3Bs

YW50IEFzcGVyZ2lsbHVzIGNvbG9uaXphdGlvbiBvZiBjeXN0aWMgZmlicm9zaXMgcGF0aWVudHMg

YW5kIHRoZSBpbmNpZGVuY2Ugb2YgcG9zdC1sdW5nIHRyYW5zcGxhbnQgaW52YXNpdmUgYXNwZXJn

aWxsb3NpczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5UcmFuc3BsYW50YXRpb248L3NlY29uZGFy

eS10aXRsZT48YWx0LXRpdGxlPlRyYW5zcGxhbnRhdGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlRyYW5zcGxhbnRhdGlvbjwvZnVsbC10aXRsZT48L3Blcmlv

ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlRyYW5zcGxhbnRhdGlvbjwvZnVsbC10

aXRsZT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4zNTEtNzwvcGFnZXM+PHZvbHVtZT45Nzwvdm9s

dW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjIwMTMvMTIvMDc8L2VkaXRpb24+PGtleXdv

cmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFudGlmdW5nYWwgQWdlbnRzL3Ro

ZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy8qcGF0aG9nZW5pY2l0

eTwva2V5d29yZD48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkL21pY3JvYmlv

bG9neTwva2V5d29yZD48a2V5d29yZD5DeXN0aWMgRmlicm9zaXMvKmNvbXBsaWNhdGlvbnMvKm1p

Y3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub3N1cHByZXNzaXZlIEFnZW50cy9hZHZlcnNlIGVm

ZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+SW5jaWRlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkludmFz

aXZlIFB1bG1vbmFyeSBBc3BlcmdpbGxvc2lzLypjb21wbGljYXRpb25zL2VwaWRlbWlvbG9neTwv

a2V5d29yZD48a2V5d29yZD5MdW5nIFRyYW5zcGxhbnRhdGlvbi8qbWV0aG9kczwva2V5d29yZD48

a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPlBvc3RvcGVyYXRpdmUgQ29tcGxpY2F0aW9u

czwva2V5d29yZD48a2V5d29yZD5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdv

cmQ+UmlzayBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlNwdXR1bS9taWNyb2Jpb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+VGltZSBGYWN0b3JzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5

ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5GZWIgMTU8L2RhdGU+PC9wdWItZGF0ZXM+

PC9kYXRlcz48aXNibj4xNTM0LTYwODAgKEVsZWN0cm9uaWMpJiN4RDswMDQxLTEzMzcgKExpbmtp

bmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0MzA1NjM3PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5

cGU+UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxz

PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI0

MzA1NjM3PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51

bT4xMC4xMDk3LzAxLlRQLjAwMDA0Mzc0MzQuNDI4NTEuZDQ8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MdW9uZzwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

Y051bT4yNjkzNDwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNDRdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjI2OTM0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNjkzNDwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+THVvbmcsIE0uIEwuPC9hdXRob3I+

PGF1dGhvcj5DaGFwYXJybywgQy48L2F1dGhvcj48YXV0aG9yPlN0ZXBoZW5zb24sIEEuPC9hdXRo

b3I+PGF1dGhvcj5Sb3RzdGVpbiwgQy48L2F1dGhvcj48YXV0aG9yPlNpbmdlciwgTC4gRy48L2F1

dGhvcj48YXV0aG9yPldhdGVycywgVi48L2F1dGhvcj48YXV0aG9yPkF6YWQsIFMuPC9hdXRob3I+

PGF1dGhvcj5LZXNoYXZqZWUsIFMuPC9hdXRob3I+PGF1dGhvcj5UdWxsaXMsIEUuPC9hdXRob3I+

PGF1dGhvcj5IdXNhaW4sIFMuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+MSBEaXZpc2lvbiBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzLCBEZXBhcnRtZW50IG9m

IE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIFRvcm9udG8sIFVuaXZlcnNpdHkgSGVhbHRoIE5ldHdv

cmssIFRvcm9udG8sIE9udGFyaW8sIENhbmFkYS4gMiBEaXZpc2lvbiBvZiBSZXNwaXJvbG9neSwg

VG9yb250byBMdW5nIFRyYW5zcGxhbnQgUHJvZ3JhbSwgVW5pdmVyc2l0eSBvZiBUb3JvbnRvLCBV

bml2ZXJzaXR5IEhlYWx0aCBOZXR3b3JrLCBUb3JvbnRvLCBPbnRhcmlvLCBDYW5hZGEuIDMgQWR1

bHQgQ3lzdGljIEZpYnJvc2lzIENlbnRyZSBhbmQgRGVwYXJ0bWVudCBvZiBSZXNwaXJhdG9yeSBN

ZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBUb3JvbnRvLCBTdCBNaWNoYWVsJmFwb3M7cyBIb3NwaXRh

bCwgVG9yb250bywgQ2FuYWRhLiA0IERpdmlzaW9uIG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIERl

cGFydG1lbnQgb2YgUGVkaWF0cmljcywgSG9zcGl0YWwgZm9yIFNpY2sgQ2hpbGRyZW4sIFRvcm9u

dG8sIE9udGFyaW8sIENhbmFkYS4gNSBEaXZpc2lvbiBvZiBUaG9yYWNpYyBTdXJnZXJ5LCBUb3Jv

bnRvIEx1bmcgVHJhbnNwbGFudCBQcm9ncmFtLCBVbml2ZXJzaXR5IG9mIFRvcm9udG8sIFVuaXZl

cnNpdHkgSGVhbHRoIE5ldHdvcmssIFRvcm9udG8sIE9udGFyaW8sIENhbmFkYS4gNiBVbml2ZXJz

aXR5IG9mIFRvcm9udG8sIEtlZW5hbiBSZXNlYXJjaCBDZW50cmUgb2YgdGhlIExpIEthIFNoaW5n

IEtub3dsZWRnZSBJbnN0aXR1dGUsIFN0IE1pY2hhZWwmYXBvcztzIEhvc3BpdGFsLCBUb3JvbnRv

LCBDYW5hZGEuIDcgQWRkcmVzcyBjb3JyZXNwb25kZW5jZSB0bzogU2hhaGlkIEh1c2FpbiwgTS5E

LiwgRGl2aXNpb24gb2YgSW5mZWN0aW91cyBEaXNlYXNlcywgRGVwYXJ0bWVudCBvZiBNZWRpY2lu

ZSwgVW5pdmVyc2l0eSBvZiBUb3JvbnRvLCBUb3JvbnRvIEdlbmVyYWwgSG9zcGl0YWwsIE5DU0Is

IDExdGggZmxvb3IsIDExYy0xMjY5LCA1ODUgVW5pdmVyc2l0eSBBdmVudWUsIFRvcm9udG8sIE9O

LCBDYW5hZGEgTTVHIDJOMi48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5QcmV0cmFuc3Bs

YW50IEFzcGVyZ2lsbHVzIGNvbG9uaXphdGlvbiBvZiBjeXN0aWMgZmlicm9zaXMgcGF0aWVudHMg

YW5kIHRoZSBpbmNpZGVuY2Ugb2YgcG9zdC1sdW5nIHRyYW5zcGxhbnQgaW52YXNpdmUgYXNwZXJn

aWxsb3NpczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5UcmFuc3BsYW50YXRpb248L3NlY29uZGFy

eS10aXRsZT48YWx0LXRpdGxlPlRyYW5zcGxhbnRhdGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlRyYW5zcGxhbnRhdGlvbjwvZnVsbC10aXRsZT48L3Blcmlv

ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlRyYW5zcGxhbnRhdGlvbjwvZnVsbC10

aXRsZT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4zNTEtNzwvcGFnZXM+PHZvbHVtZT45Nzwvdm9s

dW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjIwMTMvMTIvMDc8L2VkaXRpb24+PGtleXdv

cmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFudGlmdW5nYWwgQWdlbnRzL3Ro

ZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy8qcGF0aG9nZW5pY2l0

eTwva2V5d29yZD48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkL21pY3JvYmlv

bG9neTwva2V5d29yZD48a2V5d29yZD5DeXN0aWMgRmlicm9zaXMvKmNvbXBsaWNhdGlvbnMvKm1p

Y3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub3N1cHByZXNzaXZlIEFnZW50cy9hZHZlcnNlIGVm

ZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+SW5jaWRlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkludmFz

aXZlIFB1bG1vbmFyeSBBc3BlcmdpbGxvc2lzLypjb21wbGljYXRpb25zL2VwaWRlbWlvbG9neTwv

a2V5d29yZD48a2V5d29yZD5MdW5nIFRyYW5zcGxhbnRhdGlvbi8qbWV0aG9kczwva2V5d29yZD48

a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPlBvc3RvcGVyYXRpdmUgQ29tcGxpY2F0aW9u

czwva2V5d29yZD48a2V5d29yZD5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdv

cmQ+UmlzayBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlNwdXR1bS9taWNyb2Jpb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+VGltZSBGYWN0b3JzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5

ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5GZWIgMTU8L2RhdGU+PC9wdWItZGF0ZXM+

PC9kYXRlcz48aXNibj4xNTM0LTYwODAgKEVsZWN0cm9uaWMpJiN4RDswMDQxLTEzMzcgKExpbmtp

bmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0MzA1NjM3PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5

cGU+UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxz

PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI0

MzA1NjM3PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51

bT4xMC4xMDk3LzAxLlRQLjAwMDA0Mzc0MzQuNDI4NTEuZDQ8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [44]. Invasive aspergillosis in patients with autoimmune diseases is uncommon. Prolonged use of corticosteroids and other immunosuppressive agents and possibly pre-existing lung disease are risk factors ADDIN EN.CITE <EndNote><Cite><Author>Su</Author><Year>2009</Year><RecNum>797</RecNum><DisplayText>[45]</DisplayText><record><rec-number>797</rec-number><foreign-keys><key app="EN" db-id="25ws99rfnw2zfmert5rxzapsprpa5wr2efdr" timestamp="1454362491">797</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Su, T.</author><author>Li, H. C.</author><author>Chen, M.</author><author>Gao, L.</author><author>Zhou, F. D.</author><author>Wang, R. G.</author><author>Zhang, H.</author><author>Li, X. M.</author><author>Zhao, M. H.</author></authors></contributors><auth-address>Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.</auth-address><titles><title>Invasive pulmonary aspergillosis in patients with antineutrophil cytoplasmic antibody associated vasculitis</title><secondary-title>J Clin Rheumatol</secondary-title></titles><periodical><full-title>Journal of Clinical Rheumatology</full-title><abbr-1>J. Clin. Rheumatol.</abbr-1><abbr-2>J Clin Rheumatol</abbr-2></periodical><pages>380-2</pages><volume>15</volume><number>8</number><keywords><keyword>Aged</keyword><keyword>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*drug</keyword><keyword>therapy/immunology</keyword><keyword>Antifungal Agents/therapeutic use</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>*Immunocompromised Host</keyword><keyword>Immunosuppressive Agents/*adverse effects</keyword><keyword>Invasive Pulmonary Aspergillosis/drug therapy/*immunology</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Retrospective Studies</keyword></keywords><dates><year>2009</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>1536-7355 (Electronic)&#xD;1076-1608 (Linking)</isbn><accession-num>19279506</accession-num><urls><related-urls><url>;[45]. In the era of highly active antiretroviral therapy, invasive aspergillosis is a rare complication of human immunodeficiency virus (HIV) infection. AIDS -associated aspergillosis is most frequently associated with advanced AIDS and additional risk factors, such as neutropenia, corticosteroid use, and concurrent opportunistic infections PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NeWxvbmFraXM8L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFy

PjxSZWNOdW0+MjYyMzA8L1JlY051bT48RGlzcGxheVRleHQ+WzQ2LCA0N108L0Rpc3BsYXlUZXh0

PjxyZWNvcmQ+PHJlYy1udW1iZXI+MjYyMzA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5

IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI2

MjMwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NeWxvbmFraXMsIEUu

PC9hdXRob3I+PGF1dGhvcj5CYXJsYW0sIFQuIEYuPC9hdXRob3I+PGF1dGhvcj5GbGFuaWdhbiwg

VC48L2F1dGhvcj48YXV0aG9yPlJpY2gsIEouIEQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp

YnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgVGhlIE1pcmlhbSBI

b3NwaXRhbCwgQnJvd24gVW5pdmVyc2l0eSBNZWRpY2FsIFNjaG9vbCwgUHJvdmlkZW5jZSwgUkkg

MDI5MDYsIFVTQS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5QdWxtb25hcnkgYXNwZXJn

aWxsb3NpcyBhbmQgaW52YXNpdmUgZGlzZWFzZSBpbiBBSURTOiByZXZpZXcgb2YgMzQyIGNhc2Vz

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNoZXN0PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRs

ZT5DaGVzdDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNoZXN0

PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2hl

c3Q8L2Z1bGwtdGl0bGU+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjUxLTYyPC9wYWdlcz48dm9s

dW1lPjExNDwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxlZGl0aW9uPjE5OTgvMDcvMjM8L2Vk

aXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFJRFMtUmVsYXRlZCBPcHBvcnR1bmlzdGljIEluZmVj

dGlvbnMvZHJ1Zzwva2V5d29yZD48a2V5d29yZD50aGVyYXB5L2ltbXVub2xvZ3kvcGF0aG9sb2d5

LypwaHlzaW9wYXRob2xvZ3kvcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxrZXl3

b3JkPkFkcmVuYWwgQ29ydGV4IEhvcm1vbmVzL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5

d29yZD5BbXBob3RlcmljaW4gQi9hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2UvdGhlcmFwZXV0

aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlmdW5nYWwgQWdlbnRzL2FkbWluaXN0cmF0aW9u

ICZhbXA7IGRvc2FnZS90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxs

b3Npcy9kcnVnIHRoZXJhcHkvaW1tdW5vbG9neS9wYXRob2xvZ3kvKnBoeXNpb3BhdGhvbG9neS9w

cmV2ZW50aW9uICZhbXA7PC9rZXl3b3JkPjxrZXl3b3JkPmNvbnRyb2w8L2tleXdvcmQ+PGtleXdv

cmQ+QmlvcHN5PC9rZXl3b3JkPjxrZXl3b3JkPkJyb25jaG9hbHZlb2xhciBMYXZhZ2UgRmx1aWQv

bWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkNENCBMeW1waG9jeXRlIENvdW50PC9rZXl3

b3JkPjxrZXl3b3JkPkNvdWdoL3BoeXNpb3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5EeXNw

bmVhL3BoeXNpb3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtl

eXdvcmQ+RmV2ZXIvcGh5c2lvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBT

dHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5MdW5nIERp

c2Vhc2VzLCBGdW5nYWwvZHJ1Zzwva2V5d29yZD48a2V5d29yZD50aGVyYXB5L2ltbXVub2xvZ3kv

cGF0aG9sb2d5LypwaHlzaW9wYXRob2xvZ3kvcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3

b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TmV1dHJvcGVuaWEvY29tcGxpY2F0

aW9ucy9wcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+UHJvZ25vc2lz

PC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5TdXJ2aXZh

bCBSYXRlPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjE5OTg8L3llYXI+PHB1Yi1k

YXRlcz48ZGF0ZT5KdWw8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDEyLTM2OTIg

KFByaW50KSYjeEQ7MDAxMi0zNjkyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT45Njc0

NDc3PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+TWV0YS1BbmFseXNpcyYjeEQ7UmVzZWFyY2gg

U3VwcG9ydCwgVS5TLiBHb3YmYXBvczt0LCBQLkguUy48L3dvcmstdHlwZT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC85Njc0NDc3PC91

cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3Jk

PjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPldhbGxhY2U8L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFyPjxS

ZWNOdW0+MjYyMzE8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI2MjMxPC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0

ZjloOTBwdzJkeHpwdGVwIj4yNjIzMTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l

PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh

dXRob3I+V2FsbGFjZSwgSi4gTS48L2F1dGhvcj48YXV0aG9yPkxpbSwgUi48L2F1dGhvcj48YXV0

aG9yPkJyb3dkeSwgQi4gTC48L2F1dGhvcj48YXV0aG9yPkhvcGV3ZWxsLCBQLiBDLjwvYXV0aG9y

PjxhdXRob3I+R2xhc3Nyb3RoLCBKLjwvYXV0aG9yPjxhdXRob3I+Um9zZW4sIE0uIEouPC9hdXRo

b3I+PGF1dGhvcj5SZWljaG1hbiwgTC4gQi48L2F1dGhvcj48YXV0aG9yPkt2YWxlLCBQLiBBLjwv

YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQg

b2YgTWVkaWNpbmUsIE9saXZlIFZpZXctVUNMQSBNZWRpY2FsIENlbnRlciwgU3lsbWFyLCBDYWxp

ZiwgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlJpc2sgZmFjdG9ycyBhbmQgb3V0

Y29tZXMgYXNzb2NpYXRlZCB3aXRoIGlkZW50aWZpY2F0aW9uIG9mIEFzcGVyZ2lsbHVzIGluIHJl

c3BpcmF0b3J5IHNwZWNpbWVucyBmcm9tIHBlcnNvbnMgd2l0aCBISVYgZGlzZWFzZS4gUHVsbW9u

YXJ5IENvbXBsaWNhdGlvbnMgb2YgSElWIEluZmVjdGlvbiBTdHVkeSBHcm91cDwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5DaGVzdDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2hlc3Q8L2Fs

dC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaGVzdDwvZnVsbC10aXRs

ZT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNoZXN0PC9mdWxsLXRp

dGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEzMS03PC9wYWdlcz48dm9sdW1lPjExNDwvdm9s

dW1lPjxudW1iZXI+MTwvbnVtYmVyPjxlZGl0aW9uPjE5OTgvMDcvMjM8L2VkaXRpb24+PGtleXdv

cmRzPjxrZXl3b3JkPkFJRFMtUmVsYXRlZCBPcHBvcnR1bmlzdGljIEluZmVjdGlvbnMvKmRpYWdu

b3Npczwva2V5d29yZD48a2V5d29yZD5BZHJlbmFsIENvcnRleCBIb3Jtb25lcy90aGVyYXBldXRp

YyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxs

b3Npcy8qZGlhZ25vc2lzPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzL2lzb2xhdGlvbiAm

YW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+QnJvbmNob2FsdmVvbGFyIExhdmFn

ZSBGbHVpZC9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Q0Q0IEx5bXBob2N5dGUgQ291

bnQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2FzZS1Db250cm9sIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdv

cmQ+Q2F1c2Ugb2YgRGVhdGg8L2tleXdvcmQ+PGtleXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdv

cmQ+PGtleXdvcmQ+KkhJViBTZXJvcG9zaXRpdml0eS90cmFuc21pc3Npb248L2tleXdvcmQ+PGtl

eXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcgRGlzZWFzZXMvZGlhZ25vc2lzLypt

aWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NYXJp

anVhbmEgU21va2luZy9hZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFn

ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TmV1dHJvcGVuaWEvY29tcGxpY2F0aW9uczwva2V5d29yZD48

a2V5d29yZD5QbmV1bW9uaWEsIFBuZXVtb2N5c3Rpcy9jb21wbGljYXRpb25zPC9rZXl3b3JkPjxr

ZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5TbW9raW5nL2FkdmVyc2UgZWZm

ZWN0czwva2V5d29yZD48a2V5d29yZD5TcHV0dW0vbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3

b3JkPlN1cnZpdmFsIFJhdGU8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MTk5ODwveWVhcj48cHViLWRhdGVzPjxkYXRl

Pkp1bDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMTItMzY5MiAoUHJpbnQpJiN4

RDswMDEyLTM2OTIgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjk2NzQ0NTk8L2FjY2Vz

c2lvbi1udW0+PHdvcmstdHlwZT5Db21wYXJhdGl2ZSBTdHVkeSYjeEQ7TXVsdGljZW50ZXIgU3R1

ZHkmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIFUuUy4gR292JmFwb3M7dCwgUC5ILlMuPC93b3JrLXR5

cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9w

dWJtZWQvOTY3NDQ1OTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48bGFuZ3VhZ2U+ZW5nPC9s

YW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NeWxvbmFraXM8L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFy

PjxSZWNOdW0+MjYyMzA8L1JlY051bT48RGlzcGxheVRleHQ+WzQ2LCA0N108L0Rpc3BsYXlUZXh0

PjxyZWNvcmQ+PHJlYy1udW1iZXI+MjYyMzA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5

IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI2

MjMwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NeWxvbmFraXMsIEUu

PC9hdXRob3I+PGF1dGhvcj5CYXJsYW0sIFQuIEYuPC9hdXRob3I+PGF1dGhvcj5GbGFuaWdhbiwg

VC48L2F1dGhvcj48YXV0aG9yPlJpY2gsIEouIEQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp

YnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgVGhlIE1pcmlhbSBI

b3NwaXRhbCwgQnJvd24gVW5pdmVyc2l0eSBNZWRpY2FsIFNjaG9vbCwgUHJvdmlkZW5jZSwgUkkg

MDI5MDYsIFVTQS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5QdWxtb25hcnkgYXNwZXJn

aWxsb3NpcyBhbmQgaW52YXNpdmUgZGlzZWFzZSBpbiBBSURTOiByZXZpZXcgb2YgMzQyIGNhc2Vz

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNoZXN0PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRs

ZT5DaGVzdDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNoZXN0

PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2hl

c3Q8L2Z1bGwtdGl0bGU+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjUxLTYyPC9wYWdlcz48dm9s

dW1lPjExNDwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxlZGl0aW9uPjE5OTgvMDcvMjM8L2Vk

aXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFJRFMtUmVsYXRlZCBPcHBvcnR1bmlzdGljIEluZmVj

dGlvbnMvZHJ1Zzwva2V5d29yZD48a2V5d29yZD50aGVyYXB5L2ltbXVub2xvZ3kvcGF0aG9sb2d5

LypwaHlzaW9wYXRob2xvZ3kvcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxrZXl3

b3JkPkFkcmVuYWwgQ29ydGV4IEhvcm1vbmVzL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5

d29yZD5BbXBob3RlcmljaW4gQi9hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2UvdGhlcmFwZXV0

aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlmdW5nYWwgQWdlbnRzL2FkbWluaXN0cmF0aW9u

ICZhbXA7IGRvc2FnZS90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxs

b3Npcy9kcnVnIHRoZXJhcHkvaW1tdW5vbG9neS9wYXRob2xvZ3kvKnBoeXNpb3BhdGhvbG9neS9w

cmV2ZW50aW9uICZhbXA7PC9rZXl3b3JkPjxrZXl3b3JkPmNvbnRyb2w8L2tleXdvcmQ+PGtleXdv

cmQ+QmlvcHN5PC9rZXl3b3JkPjxrZXl3b3JkPkJyb25jaG9hbHZlb2xhciBMYXZhZ2UgRmx1aWQv

bWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkNENCBMeW1waG9jeXRlIENvdW50PC9rZXl3

b3JkPjxrZXl3b3JkPkNvdWdoL3BoeXNpb3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5EeXNw

bmVhL3BoeXNpb3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtl

eXdvcmQ+RmV2ZXIvcGh5c2lvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBT

dHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5MdW5nIERp

c2Vhc2VzLCBGdW5nYWwvZHJ1Zzwva2V5d29yZD48a2V5d29yZD50aGVyYXB5L2ltbXVub2xvZ3kv

cGF0aG9sb2d5LypwaHlzaW9wYXRob2xvZ3kvcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3

b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TmV1dHJvcGVuaWEvY29tcGxpY2F0

aW9ucy9wcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+UHJvZ25vc2lz

PC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5TdXJ2aXZh

bCBSYXRlPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjE5OTg8L3llYXI+PHB1Yi1k

YXRlcz48ZGF0ZT5KdWw8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDEyLTM2OTIg

KFByaW50KSYjeEQ7MDAxMi0zNjkyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT45Njc0

NDc3PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+TWV0YS1BbmFseXNpcyYjeEQ7UmVzZWFyY2gg

U3VwcG9ydCwgVS5TLiBHb3YmYXBvczt0LCBQLkguUy48L3dvcmstdHlwZT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC85Njc0NDc3PC91

cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3Jk

PjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPldhbGxhY2U8L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFyPjxS

ZWNOdW0+MjYyMzE8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI2MjMxPC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0

ZjloOTBwdzJkeHpwdGVwIj4yNjIzMTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l

PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh

dXRob3I+V2FsbGFjZSwgSi4gTS48L2F1dGhvcj48YXV0aG9yPkxpbSwgUi48L2F1dGhvcj48YXV0

aG9yPkJyb3dkeSwgQi4gTC48L2F1dGhvcj48YXV0aG9yPkhvcGV3ZWxsLCBQLiBDLjwvYXV0aG9y

PjxhdXRob3I+R2xhc3Nyb3RoLCBKLjwvYXV0aG9yPjxhdXRob3I+Um9zZW4sIE0uIEouPC9hdXRo

b3I+PGF1dGhvcj5SZWljaG1hbiwgTC4gQi48L2F1dGhvcj48YXV0aG9yPkt2YWxlLCBQLiBBLjwv

YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQg

b2YgTWVkaWNpbmUsIE9saXZlIFZpZXctVUNMQSBNZWRpY2FsIENlbnRlciwgU3lsbWFyLCBDYWxp

ZiwgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlJpc2sgZmFjdG9ycyBhbmQgb3V0

Y29tZXMgYXNzb2NpYXRlZCB3aXRoIGlkZW50aWZpY2F0aW9uIG9mIEFzcGVyZ2lsbHVzIGluIHJl

c3BpcmF0b3J5IHNwZWNpbWVucyBmcm9tIHBlcnNvbnMgd2l0aCBISVYgZGlzZWFzZS4gUHVsbW9u

YXJ5IENvbXBsaWNhdGlvbnMgb2YgSElWIEluZmVjdGlvbiBTdHVkeSBHcm91cDwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5DaGVzdDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2hlc3Q8L2Fs

dC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaGVzdDwvZnVsbC10aXRs

ZT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNoZXN0PC9mdWxsLXRp

dGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEzMS03PC9wYWdlcz48dm9sdW1lPjExNDwvdm9s

dW1lPjxudW1iZXI+MTwvbnVtYmVyPjxlZGl0aW9uPjE5OTgvMDcvMjM8L2VkaXRpb24+PGtleXdv

cmRzPjxrZXl3b3JkPkFJRFMtUmVsYXRlZCBPcHBvcnR1bmlzdGljIEluZmVjdGlvbnMvKmRpYWdu

b3Npczwva2V5d29yZD48a2V5d29yZD5BZHJlbmFsIENvcnRleCBIb3Jtb25lcy90aGVyYXBldXRp

YyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxs

b3Npcy8qZGlhZ25vc2lzPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzL2lzb2xhdGlvbiAm

YW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+QnJvbmNob2FsdmVvbGFyIExhdmFn

ZSBGbHVpZC9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Q0Q0IEx5bXBob2N5dGUgQ291

bnQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2FzZS1Db250cm9sIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdv

cmQ+Q2F1c2Ugb2YgRGVhdGg8L2tleXdvcmQ+PGtleXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdv

cmQ+PGtleXdvcmQ+KkhJViBTZXJvcG9zaXRpdml0eS90cmFuc21pc3Npb248L2tleXdvcmQ+PGtl

eXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcgRGlzZWFzZXMvZGlhZ25vc2lzLypt

aWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NYXJp

anVhbmEgU21va2luZy9hZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFn

ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TmV1dHJvcGVuaWEvY29tcGxpY2F0aW9uczwva2V5d29yZD48

a2V5d29yZD5QbmV1bW9uaWEsIFBuZXVtb2N5c3Rpcy9jb21wbGljYXRpb25zPC9rZXl3b3JkPjxr

ZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5TbW9raW5nL2FkdmVyc2UgZWZm

ZWN0czwva2V5d29yZD48a2V5d29yZD5TcHV0dW0vbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3

b3JkPlN1cnZpdmFsIFJhdGU8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MTk5ODwveWVhcj48cHViLWRhdGVzPjxkYXRl

Pkp1bDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMTItMzY5MiAoUHJpbnQpJiN4

RDswMDEyLTM2OTIgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjk2NzQ0NTk8L2FjY2Vz

c2lvbi1udW0+PHdvcmstdHlwZT5Db21wYXJhdGl2ZSBTdHVkeSYjeEQ7TXVsdGljZW50ZXIgU3R1

ZHkmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIFUuUy4gR292JmFwb3M7dCwgUC5ILlMuPC93b3JrLXR5

cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9w

dWJtZWQvOTY3NDQ1OTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48bGFuZ3VhZ2U+ZW5nPC9s

YW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [46, 47]. CGD, an inherited disorder of the phagocyte NADPH oxidase, is characterized by recurrent bacterial and fungal infections including IA, and other moulds, which can be life-threatening PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVuIEJlcmc8L0F1dGhvcj48WWVhcj4yMDA5PC9Z

ZWFyPjxSZWNOdW0+Njk2NzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNDgtNTFdPC9EaXNwbGF5VGV4

dD48cmVjb3JkPjxyZWMtbnVtYmVyPjY5Njc8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5

IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjY5

Njc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x

NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPnZhbiBkZW4gQmVyZywg

Si4gTS48L2F1dGhvcj48YXV0aG9yPnZhbiBLb3BwZW4sIEUuPC9hdXRob3I+PGF1dGhvcj5BaGxp

biwgQS48L2F1dGhvcj48YXV0aG9yPkJlbG9ocmFkc2t5LCBCLiBILjwvYXV0aG9yPjxhdXRob3I+

QmVybmF0b3dza2EsIEUuPC9hdXRob3I+PGF1dGhvcj5Db3JiZWVsLCBMLjwvYXV0aG9yPjxhdXRo

b3I+RXNwYW5vbCwgVC48L2F1dGhvcj48YXV0aG9yPkZpc2NoZXIsIEEuPC9hdXRob3I+PGF1dGhv

cj5LdXJlbmtvLURlcHR1Y2gsIE0uPC9hdXRob3I+PGF1dGhvcj5Nb3V5LCBSLjwvYXV0aG9yPjxh

dXRob3I+UGV0cm9wb3Vsb3UsIFQuPC9hdXRob3I+PGF1dGhvcj5Sb2VzbGVyLCBKLjwvYXV0aG9y

PjxhdXRob3I+U2VnZXIsIFIuPC9hdXRob3I+PGF1dGhvcj5TdGFzaWEsIE0uIEouPC9hdXRob3I+

PGF1dGhvcj5WYWxlcml1cywgTi4gSC48L2F1dGhvcj48YXV0aG9yPldlZW5pbmcsIFIuIFMuPC9h

dXRob3I+PGF1dGhvcj5Xb2xhY2gsIEIuPC9hdXRob3I+PGF1dGhvcj5Sb29zLCBELjwvYXV0aG9y

PjxhdXRob3I+S3VpanBlcnMsIFQuIFcuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+U2FucXVpbiBSZXNlYXJjaCwgYW5kIExhbmRzdGVpbmVyIExhYm9yYXRv

cnksIEVtbWEgQ2hpbGRyZW4mYXBvcztzIEhvc3BpdGFsLCBBY2FkZW1pYyBNZWRpY2FsIENlbnRy

ZSwgVW5pdmVyc2l0eSBvZiBBbXN0ZXJkYW0sIEFtc3RlcmRhbSwgVGhlIE5ldGhlcmxhbmRzLiBq

Lm0udmFuZGVuYmVyZ0BhbWMubmw8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5DaHJvbmlj

IGdyYW51bG9tYXRvdXMgZGlzZWFzZTogdGhlIEV1cm9wZWFuIGV4cGVyaWVuY2U8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+UExvUyBPTkU8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5QTG9TIE9ORTwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2Vz

PmU1MjM0PC9wYWdlcz48dm9sdW1lPjQ8L3ZvbHVtZT48bnVtYmVyPjQ8L251bWJlcj48ZWRpdGlv

bj4yMDA5LzA0LzIyPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5FdXJvcGUvZXBpZGVtaW9s

b2d5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5HcmFudWxvbWF0

b3VzIERpc2Vhc2UsIENocm9uaWMvZXBpZGVtaW9sb2d5L2dlbmV0aWNzLypwYXRob2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PC9r

ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48L2RhdGVzPjxpc2JuPjE5MzItNjIwMyAo

RWxlY3Ryb25pYyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTkzODEzMDE8L2FjY2Vzc2lvbi1udW0+

PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9lbnRy

ZXovcXVlcnkuZmNnaT9jbWQ9UmV0cmlldmUmYW1wO2RiPVB1Yk1lZCZhbXA7ZG9wdD1DaXRhdGlv

biZhbXA7bGlzdF91aWRzPTE5MzgxMzAxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0

b20yPjI2Njg3NDk8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEzNzEvam91

cm5hbC5wb25lLjAwMDUyMzQ8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8

L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPldpbmtlbHN0ZWluPC9BdXRo

b3I+PFllYXI+MjAwMDwvWWVhcj48UmVjTnVtPjIwMzEyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51

bWJlcj4yMDMxMjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+MjAzMTI8L2tleT48L2ZvcmVp

Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv

bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPldpbmtlbHN0ZWluLCBKLiBBLjwvYXV0aG9yPjxh

dXRob3I+TWFyaW5vLCBNLiBDLjwvYXV0aG9yPjxhdXRob3I+Sm9obnN0b24sIFIuIEIuLCBKci48

L2F1dGhvcj48YXV0aG9yPkJveWxlLCBKLjwvYXV0aG9yPjxhdXRob3I+Q3VybnV0dGUsIEouPC9h

dXRob3I+PGF1dGhvcj5HYWxsaW4sIEouIEkuPC9hdXRob3I+PGF1dGhvcj5NYWxlY2gsIEguIEwu

PC9hdXRob3I+PGF1dGhvcj5Ib2xsYW5kLCBTLiBNLjwvYXV0aG9yPjxhdXRob3I+T2NocywgSC48

L2F1dGhvcj48YXV0aG9yPlF1aWUsIFAuPC9hdXRob3I+PGF1dGhvcj5CdWNrbGV5LCBSLiBILjwv

YXV0aG9yPjxhdXRob3I+Rm9zdGVyLCBDLiBCLjwvYXV0aG9yPjxhdXRob3I+Q2hhbm9jaywgUy4g

Si48L2F1dGhvcj48YXV0aG9yPkRpY2tsZXIsIEguPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp

YnV0b3JzPjxhdXRoLWFkZHJlc3M+SW1tdW5lIERlZmljaWVuY3kgRm91bmRhdGlvbiwgQmFsdGlt

b3JlLCBNYXJ5bGFuZCwgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNocm9uaWMg

Z3JhbnVsb21hdG91cyBkaXNlYXNlLiBSZXBvcnQgb24gYSBuYXRpb25hbCByZWdpc3RyeSBvZiAz

NjggcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TWVkaWNpbmUgKEJhbHRpbW9yZSk8

L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPk1lZGljaW5lPC9hbHQtdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TWVkaWNpbmUgKEJhbHRpbW9yZSk8L2Z1bGwtdGl0bGU+

PC9wZXJpb2RpY2FsPjxwYWdlcz4xNTUtNjk8L3BhZ2VzPjx2b2x1bWU+Nzk8L3ZvbHVtZT48bnVt

YmVyPjM8L251bWJlcj48ZWRpdGlvbj4yMDAwLzA2LzA5PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5

d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2F1c2Ugb2YgRGVhdGg8L2tleXdvcmQ+PGtleXdvcmQ+

Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29y

ZD5Db21tdW5pY2FibGUgRGlzZWFzZXMvZXBpZGVtaW9sb2d5L2V0aW9sb2d5PC9rZXl3b3JkPjxr

ZXl3b3JkPkNvbnRpbmVudGFsIFBvcHVsYXRpb24gR3JvdXBzPC9rZXl3b3JkPjxrZXl3b3JkPkZl

bWFsZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwva2V5d29yZD48a2V5d29y

ZD5HcmFudWxvbWF0b3VzIERpc2Vhc2UsIENocm9uaWMvY29tcGxpY2F0aW9ucy8qZXBpZGVtaW9s

b2d5L2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5J

bmNpZGVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+SW5mYW50PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8

L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UHJldmFsZW5j

ZTwva2V5d29yZD48a2V5d29yZD4qUmVnaXN0cmllczwva2V5d29yZD48a2V5d29yZD5TdXJ2aXZh

bCBBbmFseXNpczwva2V5d29yZD48a2V5d29yZD5Vbml0ZWQgU3RhdGVzL2VwaWRlbWlvbG9neTwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAwPC95ZWFyPjxwdWItZGF0ZXM+PGRh

dGU+TWF5PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAyNS03OTc0IChQcmludCkm

I3hEOzAwMjUtNzk3NCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTA4NDQ5MzU8L2Fj

Y2Vzc2lvbi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBVLlMuIEdvdiZhcG9zO3Qs

IFAuSC5TLjwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5j

YmkubmxtLm5paC5nb3YvcHVibWVkLzEwODQ0OTM1PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxz

PjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlNl

Z2FsPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48UmVjTnVtPjQ0MzM8L1JlY051bT48cmVjb3Jk

PjxyZWMtbnVtYmVyPjQ0MzM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjQ0MzM8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNlZ2FsLCBCLiBILjwvYXV0aG9yPjxh

dXRob3I+RGVDYXJsbywgRS4gUy48L2F1dGhvcj48YXV0aG9yPkt3b24tQ2h1bmcsIEsuIEouPC9h

dXRob3I+PGF1dGhvcj5NYWxlY2gsIEguIEwuPC9hdXRob3I+PGF1dGhvcj5HYWxsaW4sIEouIEku

PC9hdXRob3I+PGF1dGhvcj5Ib2xsYW5kLCBTLiBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5Bc3BlcmdpbGx1cyBuaWR1bGFucyBpbmZlY3Rpb24gaW4g

Y2hyb25pYyBncmFudWxvbWF0b3VzIGRpc2Vhc2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TWVk

aWNpbmUgKEJhbHRpbW9yZSk8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48

ZnVsbC10aXRsZT5NZWRpY2luZSAoQmFsdGltb3JlKTwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+

PHBhZ2VzPjM0NS01NC48L3BhZ2VzPjx2b2x1bWU+Nzc8L3ZvbHVtZT48bnVtYmVyPjU8L251bWJl

cj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VuY2U8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8

L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qY29tcGxpY2F0aW9ucy9kaWFnbm9zaXMv

dGhlcmFweTwva2V5d29yZD48a2V5d29yZD4qQXNwZXJnaWxsdXMgbmlkdWxhbnM8L2tleXdvcmQ+

PGtleXdvcmQ+Q2FzZSBSZXBvcnQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtl

eXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5HcmFudWxvbWF0b3VzIERp

c2Vhc2UsIENocm9uaWMvKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW48L2tl

eXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk4

PC95ZWFyPjwvZGF0ZXM+PGxhYmVsPjk4NDQ2MTAwPC9sYWJlbD48dXJscz48L3VybHM+PC9yZWNv

cmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+U2VnYWw8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS

ZWNOdW0+NjE1MjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NjE1MjwvcmVjLW51bWJlcj48

Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5

aDkwcHcyZHh6cHRlcCI+NjE1Mjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK

b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo

b3I+U2VnYWwsIEIuIEguPC9hdXRob3I+PGF1dGhvcj5CYXJuaGFydCwgTC4gQS48L2F1dGhvcj48

YXV0aG9yPkFuZGVyc29uLCBWLiBMLjwvYXV0aG9yPjxhdXRob3I+V2Fsc2gsIFQuIEouPC9hdXRo

b3I+PGF1dGhvcj5NYWxlY2gsIEguIEwuPC9hdXRob3I+PGF1dGhvcj5Ib2xsYW5kLCBTLiBNLjwv

YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5Qb3NhY29uYXpv

bGUgYXMgc2FsdmFnZSB0aGVyYXB5IGluIHBhdGllbnRzIHdpdGggY2hyb25pYyBncmFudWxvbWF0

b3VzIGRpc2Vhc2Ugd2l0aCBpbnZhc2l2ZSBmaWxhbWVudG91cyBmdW5nYWwgaW5mZWN0aW9uPC90

aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW4gSW5mZWN0IERpczwvZnVsbC10aXRs

ZT48L3BlcmlvZGljYWw+PHBhZ2VzPjE2ODQtODwvcGFnZXM+PHZvbHVtZT40MDwvdm9sdW1lPjxk

YXRlcz48eWVhcj4yMDA1PC95ZWFyPjwvZGF0ZXM+PHB1Yi1sb2NhdGlvbj5DaGljYWdvLCBJTDwv

cHViLWxvY2F0aW9uPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVuIEJlcmc8L0F1dGhvcj48WWVhcj4yMDA5PC9Z

ZWFyPjxSZWNOdW0+Njk2NzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNDgtNTFdPC9EaXNwbGF5VGV4

dD48cmVjb3JkPjxyZWMtbnVtYmVyPjY5Njc8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5

IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjY5

Njc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x

NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPnZhbiBkZW4gQmVyZywg

Si4gTS48L2F1dGhvcj48YXV0aG9yPnZhbiBLb3BwZW4sIEUuPC9hdXRob3I+PGF1dGhvcj5BaGxp

biwgQS48L2F1dGhvcj48YXV0aG9yPkJlbG9ocmFkc2t5LCBCLiBILjwvYXV0aG9yPjxhdXRob3I+

QmVybmF0b3dza2EsIEUuPC9hdXRob3I+PGF1dGhvcj5Db3JiZWVsLCBMLjwvYXV0aG9yPjxhdXRo

b3I+RXNwYW5vbCwgVC48L2F1dGhvcj48YXV0aG9yPkZpc2NoZXIsIEEuPC9hdXRob3I+PGF1dGhv

cj5LdXJlbmtvLURlcHR1Y2gsIE0uPC9hdXRob3I+PGF1dGhvcj5Nb3V5LCBSLjwvYXV0aG9yPjxh

dXRob3I+UGV0cm9wb3Vsb3UsIFQuPC9hdXRob3I+PGF1dGhvcj5Sb2VzbGVyLCBKLjwvYXV0aG9y

PjxhdXRob3I+U2VnZXIsIFIuPC9hdXRob3I+PGF1dGhvcj5TdGFzaWEsIE0uIEouPC9hdXRob3I+

PGF1dGhvcj5WYWxlcml1cywgTi4gSC48L2F1dGhvcj48YXV0aG9yPldlZW5pbmcsIFIuIFMuPC9h

dXRob3I+PGF1dGhvcj5Xb2xhY2gsIEIuPC9hdXRob3I+PGF1dGhvcj5Sb29zLCBELjwvYXV0aG9y

PjxhdXRob3I+S3VpanBlcnMsIFQuIFcuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+U2FucXVpbiBSZXNlYXJjaCwgYW5kIExhbmRzdGVpbmVyIExhYm9yYXRv

cnksIEVtbWEgQ2hpbGRyZW4mYXBvcztzIEhvc3BpdGFsLCBBY2FkZW1pYyBNZWRpY2FsIENlbnRy

ZSwgVW5pdmVyc2l0eSBvZiBBbXN0ZXJkYW0sIEFtc3RlcmRhbSwgVGhlIE5ldGhlcmxhbmRzLiBq

Lm0udmFuZGVuYmVyZ0BhbWMubmw8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5DaHJvbmlj

IGdyYW51bG9tYXRvdXMgZGlzZWFzZTogdGhlIEV1cm9wZWFuIGV4cGVyaWVuY2U8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+UExvUyBPTkU8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5QTG9TIE9ORTwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2Vz

PmU1MjM0PC9wYWdlcz48dm9sdW1lPjQ8L3ZvbHVtZT48bnVtYmVyPjQ8L251bWJlcj48ZWRpdGlv

bj4yMDA5LzA0LzIyPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5FdXJvcGUvZXBpZGVtaW9s

b2d5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5HcmFudWxvbWF0

b3VzIERpc2Vhc2UsIENocm9uaWMvZXBpZGVtaW9sb2d5L2dlbmV0aWNzLypwYXRob2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PC9r

ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48L2RhdGVzPjxpc2JuPjE5MzItNjIwMyAo

RWxlY3Ryb25pYyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTkzODEzMDE8L2FjY2Vzc2lvbi1udW0+

PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9lbnRy

ZXovcXVlcnkuZmNnaT9jbWQ9UmV0cmlldmUmYW1wO2RiPVB1Yk1lZCZhbXA7ZG9wdD1DaXRhdGlv

biZhbXA7bGlzdF91aWRzPTE5MzgxMzAxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0

b20yPjI2Njg3NDk8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEzNzEvam91

cm5hbC5wb25lLjAwMDUyMzQ8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8

L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPldpbmtlbHN0ZWluPC9BdXRo

b3I+PFllYXI+MjAwMDwvWWVhcj48UmVjTnVtPjIwMzEyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51

bWJlcj4yMDMxMjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5aDkwcHcyZHh6cHRlcCI+MjAzMTI8L2tleT48L2ZvcmVp

Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv

bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPldpbmtlbHN0ZWluLCBKLiBBLjwvYXV0aG9yPjxh

dXRob3I+TWFyaW5vLCBNLiBDLjwvYXV0aG9yPjxhdXRob3I+Sm9obnN0b24sIFIuIEIuLCBKci48

L2F1dGhvcj48YXV0aG9yPkJveWxlLCBKLjwvYXV0aG9yPjxhdXRob3I+Q3VybnV0dGUsIEouPC9h

dXRob3I+PGF1dGhvcj5HYWxsaW4sIEouIEkuPC9hdXRob3I+PGF1dGhvcj5NYWxlY2gsIEguIEwu

PC9hdXRob3I+PGF1dGhvcj5Ib2xsYW5kLCBTLiBNLjwvYXV0aG9yPjxhdXRob3I+T2NocywgSC48

L2F1dGhvcj48YXV0aG9yPlF1aWUsIFAuPC9hdXRob3I+PGF1dGhvcj5CdWNrbGV5LCBSLiBILjwv

YXV0aG9yPjxhdXRob3I+Rm9zdGVyLCBDLiBCLjwvYXV0aG9yPjxhdXRob3I+Q2hhbm9jaywgUy4g

Si48L2F1dGhvcj48YXV0aG9yPkRpY2tsZXIsIEguPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp

YnV0b3JzPjxhdXRoLWFkZHJlc3M+SW1tdW5lIERlZmljaWVuY3kgRm91bmRhdGlvbiwgQmFsdGlt

b3JlLCBNYXJ5bGFuZCwgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNocm9uaWMg

Z3JhbnVsb21hdG91cyBkaXNlYXNlLiBSZXBvcnQgb24gYSBuYXRpb25hbCByZWdpc3RyeSBvZiAz

NjggcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TWVkaWNpbmUgKEJhbHRpbW9yZSk8

L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPk1lZGljaW5lPC9hbHQtdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TWVkaWNpbmUgKEJhbHRpbW9yZSk8L2Z1bGwtdGl0bGU+

PC9wZXJpb2RpY2FsPjxwYWdlcz4xNTUtNjk8L3BhZ2VzPjx2b2x1bWU+Nzk8L3ZvbHVtZT48bnVt

YmVyPjM8L251bWJlcj48ZWRpdGlvbj4yMDAwLzA2LzA5PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5

d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2F1c2Ugb2YgRGVhdGg8L2tleXdvcmQ+PGtleXdvcmQ+

Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29y

ZD5Db21tdW5pY2FibGUgRGlzZWFzZXMvZXBpZGVtaW9sb2d5L2V0aW9sb2d5PC9rZXl3b3JkPjxr

ZXl3b3JkPkNvbnRpbmVudGFsIFBvcHVsYXRpb24gR3JvdXBzPC9rZXl3b3JkPjxrZXl3b3JkPkZl

bWFsZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwva2V5d29yZD48a2V5d29y

ZD5HcmFudWxvbWF0b3VzIERpc2Vhc2UsIENocm9uaWMvY29tcGxpY2F0aW9ucy8qZXBpZGVtaW9s

b2d5L2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5J

bmNpZGVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+SW5mYW50PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8

L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UHJldmFsZW5j

ZTwva2V5d29yZD48a2V5d29yZD4qUmVnaXN0cmllczwva2V5d29yZD48a2V5d29yZD5TdXJ2aXZh

bCBBbmFseXNpczwva2V5d29yZD48a2V5d29yZD5Vbml0ZWQgU3RhdGVzL2VwaWRlbWlvbG9neTwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAwPC95ZWFyPjxwdWItZGF0ZXM+PGRh

dGU+TWF5PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAyNS03OTc0IChQcmludCkm

I3hEOzAwMjUtNzk3NCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTA4NDQ5MzU8L2Fj

Y2Vzc2lvbi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBVLlMuIEdvdiZhcG9zO3Qs

IFAuSC5TLjwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5j

YmkubmxtLm5paC5nb3YvcHVibWVkLzEwODQ0OTM1PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxz

PjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlNl

Z2FsPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48UmVjTnVtPjQ0MzM8L1JlY051bT48cmVjb3Jk

PjxyZWMtbnVtYmVyPjQ0MzM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjQ0MzM8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNlZ2FsLCBCLiBILjwvYXV0aG9yPjxh

dXRob3I+RGVDYXJsbywgRS4gUy48L2F1dGhvcj48YXV0aG9yPkt3b24tQ2h1bmcsIEsuIEouPC9h

dXRob3I+PGF1dGhvcj5NYWxlY2gsIEguIEwuPC9hdXRob3I+PGF1dGhvcj5HYWxsaW4sIEouIEku

PC9hdXRob3I+PGF1dGhvcj5Ib2xsYW5kLCBTLiBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5Bc3BlcmdpbGx1cyBuaWR1bGFucyBpbmZlY3Rpb24gaW4g

Y2hyb25pYyBncmFudWxvbWF0b3VzIGRpc2Vhc2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TWVk

aWNpbmUgKEJhbHRpbW9yZSk8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48

ZnVsbC10aXRsZT5NZWRpY2luZSAoQmFsdGltb3JlKTwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+

PHBhZ2VzPjM0NS01NC48L3BhZ2VzPjx2b2x1bWU+Nzc8L3ZvbHVtZT48bnVtYmVyPjU8L251bWJl

cj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VuY2U8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8

L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qY29tcGxpY2F0aW9ucy9kaWFnbm9zaXMv

dGhlcmFweTwva2V5d29yZD48a2V5d29yZD4qQXNwZXJnaWxsdXMgbmlkdWxhbnM8L2tleXdvcmQ+

PGtleXdvcmQ+Q2FzZSBSZXBvcnQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtl

eXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5HcmFudWxvbWF0b3VzIERp

c2Vhc2UsIENocm9uaWMvKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW48L2tl

eXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk4

PC95ZWFyPjwvZGF0ZXM+PGxhYmVsPjk4NDQ2MTAwPC9sYWJlbD48dXJscz48L3VybHM+PC9yZWNv

cmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+U2VnYWw8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS

ZWNOdW0+NjE1MjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NjE1MjwvcmVjLW51bWJlcj48

Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImE5YTB6ZHdzOXM5MGF2ZTl4cm14dGY5

aDkwcHcyZHh6cHRlcCI+NjE1Mjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK

b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo

b3I+U2VnYWwsIEIuIEguPC9hdXRob3I+PGF1dGhvcj5CYXJuaGFydCwgTC4gQS48L2F1dGhvcj48

YXV0aG9yPkFuZGVyc29uLCBWLiBMLjwvYXV0aG9yPjxhdXRob3I+V2Fsc2gsIFQuIEouPC9hdXRo

b3I+PGF1dGhvcj5NYWxlY2gsIEguIEwuPC9hdXRob3I+PGF1dGhvcj5Ib2xsYW5kLCBTLiBNLjwv

YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5Qb3NhY29uYXpv

bGUgYXMgc2FsdmFnZSB0aGVyYXB5IGluIHBhdGllbnRzIHdpdGggY2hyb25pYyBncmFudWxvbWF0

b3VzIGRpc2Vhc2Ugd2l0aCBpbnZhc2l2ZSBmaWxhbWVudG91cyBmdW5nYWwgaW5mZWN0aW9uPC90

aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW4gSW5mZWN0IERpczwvZnVsbC10aXRs

ZT48L3BlcmlvZGljYWw+PHBhZ2VzPjE2ODQtODwvcGFnZXM+PHZvbHVtZT40MDwvdm9sdW1lPjxk

YXRlcz48eWVhcj4yMDA1PC95ZWFyPjwvZGF0ZXM+PHB1Yi1sb2NhdGlvbj5DaGljYWdvLCBJTDwv

cHViLWxvY2F0aW9uPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [48-51]. Several agents that target immune cell populations and signaling pathways, including malignancies and autoimmune disorders, have also been identified as risk factors for IA. For example, alemtuzumab (anti-CD52) can lead to neutropenia and prolonged suppression of cell-mediated immunity, potentially cytomegalovirus reactivation ADDIN EN.CITE <EndNote><Cite><Author>Skoetz</Author><Year>2012</Year><RecNum>26484</RecNum><DisplayText>[52]</DisplayText><record><rec-number>26484</rec-number><foreign-keys><key app="EN" db-id="a9a0zdws9s90ave9xrmxtf9h90pw2dxzptep">26484</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Skoetz, N.</author><author>Bauer, K.</author><author>Elter, T.</author><author>Monsef, I.</author><author>Roloff, V.</author><author>Hallek, M.</author><author>Engert, A.</author></authors></contributors><auth-address>Cochrane Haematological Malignancies Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne,Germany. nicole.skoetz@uk-koeln.de.</auth-address><titles><title>Alemtuzumab for patients with chronic lymphocytic leukaemia</title><secondary-title>Cochrane Database Syst Rev</secondary-title><alt-title>The Cochrane database of systematic reviews</alt-title></titles><periodical><full-title>Cochrane Database Syst Rev</full-title></periodical><pages>CD008078</pages><volume>2</volume><edition>2012/02/18</edition><keywords><keyword>Antibodies, Monoclonal, Humanized/*therapeutic use</keyword><keyword>Antibodies, Monoclonal, Murine-Derived/therapeutic use</keyword><keyword>Antineoplastic Agents/*therapeutic use</keyword><keyword>Chlorambucil/therapeutic use</keyword><keyword>Humans</keyword><keyword>Leukemia, Lymphocytic, Chronic, B-Cell/*drug therapy/mortality</keyword><keyword>Randomized Controlled Trials as Topic</keyword><keyword>Vidarabine/analogs &amp; derivatives/therapeutic use</keyword></keywords><dates><year>2012</year></dates><isbn>1469-493X (Electronic)&#xD;1361-6137 (Linking)</isbn><accession-num>22336834</accession-num><work-type>Meta-Analysis&#xD;Research Support, Non-U.S. Gov&apos;t&#xD;Review</work-type><urls><related-urls><url>;[52], and subsequent IA PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MdW5kaW48L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS

ZWNOdW0+MjY3NzU8L1JlY051bT48RGlzcGxheVRleHQ+WzUzLCA1NF08L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MjY3NzU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI2Nzc1

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5MdW5kaW4sIEouPC9hdXRo

b3I+PGF1dGhvcj5IYWdiZXJnLCBILjwvYXV0aG9yPjxhdXRob3I+UmVwcCwgUi48L2F1dGhvcj48

YXV0aG9yPkNhdmFsbGluLVN0YWhsLCBFLjwvYXV0aG9yPjxhdXRob3I+RnJlZGVuLCBTLjwvYXV0

aG9yPjxhdXRob3I+SnVsaXVzc29uLCBHLjwvYXV0aG9yPjxhdXRob3I+Um9zZW5ibGFkLCBFLjwv

YXV0aG9yPjxhdXRob3I+VGpvbm5mam9yZCwgRy48L2F1dGhvcj48YXV0aG9yPldpa2x1bmQsIFQu

PC9hdXRob3I+PGF1dGhvcj5Pc3RlcmJvcmcsIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp

YnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBIZW1hdG9sb2d5L09uY29sb2d5LCBL

YXJvbGluc2thIEhvc3BpdGFsLCBTdG9ja2hvbG0sIFN3ZWRlbi48L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5QaGFzZSAyIHN0dWR5IG9mIGFsZW10dXp1bWFiIChhbnRpLUNENTIgbW9ub2Ns

b25hbCBhbnRpYm9keSkgaW4gcGF0aWVudHMgd2l0aCBhZHZhbmNlZCBteWNvc2lzIGZ1bmdvaWRl

cy9TZXphcnkgc3luZHJvbWU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qmxvb2Q8L3NlY29uZGFy

eS10aXRsZT48YWx0LXRpdGxlPkJsb29kPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+Qmxvb2Q8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5CbG9vZDwvZnVsbC10aXRsZT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz40

MjY3LTcyPC9wYWdlcz48dm9sdW1lPjEwMTwvdm9sdW1lPjxudW1iZXI+MTE8L251bWJlcj48ZWRp

dGlvbj4yMDAzLzAxLzI1PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29y

ZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlib2RpZXMsIE1vbm9jbG9uYWwv

KmFkbWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZS90b3hpY2l0eTwva2V5d29yZD48a2V5d29yZD5B

bnRpYm9kaWVzLCBNb25vY2xvbmFsLCBIdW1hbml6ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWJv

ZGllcywgTmVvcGxhc20vKmFkbWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZS90b3hpY2l0eTwva2V5

d29yZD48a2V5d29yZD5BbnRpbmVvcGxhc3RpYyBBZ2VudHMvKmFkbWluaXN0cmF0aW9uICZhbXA7

IGRvc2FnZS90b3hpY2l0eTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv

cmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXljb3NpcyBGdW5nb2lkZXMvY29tcGxp

Y2F0aW9ucy8qZHJ1ZyB0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPk9wcG9ydHVuaXN0aWMgSW5m

ZWN0aW9ucy9jaGVtaWNhbGx5IGluZHVjZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UHJ1cml0dXMvZHJ1

ZyB0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlJlbWlzc2lvbiBJbmR1Y3Rpb248L2tleXdvcmQ+

PGtleXdvcmQ+U2V6YXJ5IFN5bmRyb21lL2NvbXBsaWNhdGlvbnMvKmRydWcgdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5TdXJ2aXZhbCBBbmFseXNpczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1l

bnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAzPC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+SnVuIDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDA2

LTQ5NzEgKFByaW50KSYjeEQ7MDAwNi00OTcxIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51

bT4xMjU0Mzg2MjwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPkNsaW5pY2FsIFRyaWFsJiN4RDtD

bGluaWNhbCBUcmlhbCwgUGhhc2UgSUkmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdv

diZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5u

Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xMjU0Mzg2MjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE4Mi9ibG9vZC0yMDAyLTA5LTI4MDI8L2Vs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkdhbGxhbWluaTwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJl

Y051bT4yNjc3MDwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjY3NzA8L3JlYy1udW1iZXI+

PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRm

OWg5MHB3MmR4enB0ZXAiPjI2NzcwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5HYWxsYW1pbmksIEEuPC9hdXRob3I+PGF1dGhvcj5aYWphLCBGLjwvYXV0aG9yPjxhdXRo

b3I+UGF0dGksIEMuPC9hdXRob3I+PGF1dGhvcj5CaWxsaW8sIEEuPC9hdXRob3I+PGF1dGhvcj5T

cGVjY2hpYSwgTS4gUi48L2F1dGhvcj48YXV0aG9yPlR1Y2NpLCBBLjwvYXV0aG9yPjxhdXRob3I+

TGV2aXMsIEEuPC9hdXRob3I+PGF1dGhvcj5NYW5uYSwgQS48L2F1dGhvcj48YXV0aG9yPlNlY29u

ZG8sIFYuPC9hdXRob3I+PGF1dGhvcj5SaWdhY2NpLCBMLjwvYXV0aG9yPjxhdXRob3I+UGludG8s

IEEuPC9hdXRob3I+PGF1dGhvcj5JYW5uaXR0bywgRS48L2F1dGhvcj48YXV0aG9yPlpvbGksIFYu

PC9hdXRob3I+PGF1dGhvcj5Ub3JjaGlvLCBQLjwvYXV0aG9yPjxhdXRob3I+UGlsZXJpLCBTLjwv

YXV0aG9yPjxhdXRob3I+VGFyZWxsYSwgQy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5IZW1hdG9sb2d5IERlcGFydG1lbnQsIE9zcGVkYWxlIFNhbnRhIENy

b2NlLCBDdW5lbywgSXRhbHkuIGdhbGxhbWluaS5hQG9zcGVkYWxlLmN1bmVvLml0PC9hdXRoLWFk

ZHJlc3M+PHRpdGxlcz48dGl0bGU+QWxlbXR1enVtYWIgKENhbXBhdGgtMUgpIGFuZCBDSE9QIGNo

ZW1vdGhlcmFweSBhcyBmaXJzdC1saW5lIHRyZWF0bWVudCBvZiBwZXJpcGhlcmFsIFQtY2VsbCBs

eW1waG9tYTogcmVzdWx0cyBvZiBhIEdJVElMIChHcnVwcG8gSXRhbGlhbm8gVGVyYXBpZSBJbm5v

dmF0aXZlIG5laSBMaW5mb21pKSBwcm9zcGVjdGl2ZSBtdWx0aWNlbnRlciB0cmlhbDwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5CbG9vZDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Qmxvb2Q8

L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CbG9vZDwvZnVsbC10

aXRsZT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJsb29kPC9mdWxs

LXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIzMTYtMjM8L3BhZ2VzPjx2b2x1bWU+MTEw

PC92b2x1bWU+PG51bWJlcj43PC9udW1iZXI+PGVkaXRpb24+MjAwNy8wNi8yMjwvZWRpdGlvbj48

a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48

a2V5d29yZD5BbnRpYm9kaWVzLCBNb25vY2xvbmFsL2FkdmVyc2UgZWZmZWN0cy8qdGhlcmFwZXV0

aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlib2RpZXMsIE1vbm9jbG9uYWwsIEh1bWFuaXpl

ZDwva2V5d29yZD48a2V5d29yZD5BbnRpYm9kaWVzLCBOZW9wbGFzbS9hZHZlcnNlIGVmZmVjdHMv

KnRoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5BbnRpZ2VucywgQ0QvbWV0YWJvbGlz

bTwva2V5d29yZD48a2V5d29yZD5BbnRpZ2VucywgTmVvcGxhc20vbWV0YWJvbGlzbTwva2V5d29y

ZD48a2V5d29yZD5BbnRpbmVvcGxhc3RpYyBDb21iaW5lZCBDaGVtb3RoZXJhcHkgUHJvdG9jb2xz

L2FkdmVyc2UgZWZmZWN0cy8qdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkN5Y2xv

cGhvc3BoYW1pZGUvYWR2ZXJzZSBlZmZlY3RzL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5

d29yZD5Eb3NlLVJlc3BvbnNlIFJlbGF0aW9uc2hpcCwgRHJ1Zzwva2V5d29yZD48a2V5d29yZD5E

b3hvcnViaWNpbi9hZHZlcnNlIGVmZmVjdHMvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3

b3JkPkdseWNvcHJvdGVpbnMvbWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+SXRhbHk8L2tleXdvcmQ+PGtleXdvcmQ+S2FwbGFuLU1laWVyIEVzdGlt

YXRlPC9rZXl3b3JkPjxrZXl3b3JkPkx5bXBob21hLCBULUNlbGwsIFBlcmlwaGVyYWwvKmRydWcg

dGhlcmFweS9tZXRhYm9saXNtLypwYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFn

ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXVsdGljZW50ZXIgU3R1ZGllcyBhcyBUb3BpYzwva2V5d29y

ZD48a2V5d29yZD5QcmVkbmlzb25lL2FkdmVyc2UgZWZmZWN0cy90aGVyYXBldXRpYyB1c2U8L2tl

eXdvcmQ+PGtleXdvcmQ+KlNvY2lldGllcywgTWVkaWNhbDwva2V5d29yZD48a2V5d29yZD5WaW5j

cmlzdGluZS9hZHZlcnNlIGVmZmVjdHMvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMDc8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5PY3QgMTwvZGF0ZT48

L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMDYtNDk3MSAoUHJpbnQpJiN4RDswMDA2LTQ5NzEg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE3NTgxOTE4PC9hY2Nlc3Npb24tbnVtPjx3

b3JrLXR5cGU+Q2xpbmljYWwgVHJpYWwmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdv

diZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5u

Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xNzU4MTkxODwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE4Mi9ibG9vZC0yMDA3LTAyLTA3NDY0MTwv

ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+

PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MdW5kaW48L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS

ZWNOdW0+MjY3NzU8L1JlY051bT48RGlzcGxheVRleHQ+WzUzLCA1NF08L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MjY3NzU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI2Nzc1

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5MdW5kaW4sIEouPC9hdXRo

b3I+PGF1dGhvcj5IYWdiZXJnLCBILjwvYXV0aG9yPjxhdXRob3I+UmVwcCwgUi48L2F1dGhvcj48

YXV0aG9yPkNhdmFsbGluLVN0YWhsLCBFLjwvYXV0aG9yPjxhdXRob3I+RnJlZGVuLCBTLjwvYXV0

aG9yPjxhdXRob3I+SnVsaXVzc29uLCBHLjwvYXV0aG9yPjxhdXRob3I+Um9zZW5ibGFkLCBFLjwv

YXV0aG9yPjxhdXRob3I+VGpvbm5mam9yZCwgRy48L2F1dGhvcj48YXV0aG9yPldpa2x1bmQsIFQu

PC9hdXRob3I+PGF1dGhvcj5Pc3RlcmJvcmcsIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp

YnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBIZW1hdG9sb2d5L09uY29sb2d5LCBL

YXJvbGluc2thIEhvc3BpdGFsLCBTdG9ja2hvbG0sIFN3ZWRlbi48L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5QaGFzZSAyIHN0dWR5IG9mIGFsZW10dXp1bWFiIChhbnRpLUNENTIgbW9ub2Ns

b25hbCBhbnRpYm9keSkgaW4gcGF0aWVudHMgd2l0aCBhZHZhbmNlZCBteWNvc2lzIGZ1bmdvaWRl

cy9TZXphcnkgc3luZHJvbWU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qmxvb2Q8L3NlY29uZGFy

eS10aXRsZT48YWx0LXRpdGxlPkJsb29kPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+Qmxvb2Q8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5CbG9vZDwvZnVsbC10aXRsZT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz40

MjY3LTcyPC9wYWdlcz48dm9sdW1lPjEwMTwvdm9sdW1lPjxudW1iZXI+MTE8L251bWJlcj48ZWRp

dGlvbj4yMDAzLzAxLzI1PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29y

ZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlib2RpZXMsIE1vbm9jbG9uYWwv

KmFkbWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZS90b3hpY2l0eTwva2V5d29yZD48a2V5d29yZD5B

bnRpYm9kaWVzLCBNb25vY2xvbmFsLCBIdW1hbml6ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWJv

ZGllcywgTmVvcGxhc20vKmFkbWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZS90b3hpY2l0eTwva2V5

d29yZD48a2V5d29yZD5BbnRpbmVvcGxhc3RpYyBBZ2VudHMvKmFkbWluaXN0cmF0aW9uICZhbXA7

IGRvc2FnZS90b3hpY2l0eTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv

cmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXljb3NpcyBGdW5nb2lkZXMvY29tcGxp

Y2F0aW9ucy8qZHJ1ZyB0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPk9wcG9ydHVuaXN0aWMgSW5m

ZWN0aW9ucy9jaGVtaWNhbGx5IGluZHVjZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UHJ1cml0dXMvZHJ1

ZyB0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlJlbWlzc2lvbiBJbmR1Y3Rpb248L2tleXdvcmQ+

PGtleXdvcmQ+U2V6YXJ5IFN5bmRyb21lL2NvbXBsaWNhdGlvbnMvKmRydWcgdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5TdXJ2aXZhbCBBbmFseXNpczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1l

bnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAzPC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+SnVuIDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDA2

LTQ5NzEgKFByaW50KSYjeEQ7MDAwNi00OTcxIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51

bT4xMjU0Mzg2MjwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPkNsaW5pY2FsIFRyaWFsJiN4RDtD

bGluaWNhbCBUcmlhbCwgUGhhc2UgSUkmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdv

diZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5u

Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xMjU0Mzg2MjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE4Mi9ibG9vZC0yMDAyLTA5LTI4MDI8L2Vs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkdhbGxhbWluaTwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJl

Y051bT4yNjc3MDwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjY3NzA8L3JlYy1udW1iZXI+

PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRm

OWg5MHB3MmR4enB0ZXAiPjI2NzcwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5HYWxsYW1pbmksIEEuPC9hdXRob3I+PGF1dGhvcj5aYWphLCBGLjwvYXV0aG9yPjxhdXRo

b3I+UGF0dGksIEMuPC9hdXRob3I+PGF1dGhvcj5CaWxsaW8sIEEuPC9hdXRob3I+PGF1dGhvcj5T

cGVjY2hpYSwgTS4gUi48L2F1dGhvcj48YXV0aG9yPlR1Y2NpLCBBLjwvYXV0aG9yPjxhdXRob3I+

TGV2aXMsIEEuPC9hdXRob3I+PGF1dGhvcj5NYW5uYSwgQS48L2F1dGhvcj48YXV0aG9yPlNlY29u

ZG8sIFYuPC9hdXRob3I+PGF1dGhvcj5SaWdhY2NpLCBMLjwvYXV0aG9yPjxhdXRob3I+UGludG8s

IEEuPC9hdXRob3I+PGF1dGhvcj5JYW5uaXR0bywgRS48L2F1dGhvcj48YXV0aG9yPlpvbGksIFYu

PC9hdXRob3I+PGF1dGhvcj5Ub3JjaGlvLCBQLjwvYXV0aG9yPjxhdXRob3I+UGlsZXJpLCBTLjwv

YXV0aG9yPjxhdXRob3I+VGFyZWxsYSwgQy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5IZW1hdG9sb2d5IERlcGFydG1lbnQsIE9zcGVkYWxlIFNhbnRhIENy

b2NlLCBDdW5lbywgSXRhbHkuIGdhbGxhbWluaS5hQG9zcGVkYWxlLmN1bmVvLml0PC9hdXRoLWFk

ZHJlc3M+PHRpdGxlcz48dGl0bGU+QWxlbXR1enVtYWIgKENhbXBhdGgtMUgpIGFuZCBDSE9QIGNo

ZW1vdGhlcmFweSBhcyBmaXJzdC1saW5lIHRyZWF0bWVudCBvZiBwZXJpcGhlcmFsIFQtY2VsbCBs

eW1waG9tYTogcmVzdWx0cyBvZiBhIEdJVElMIChHcnVwcG8gSXRhbGlhbm8gVGVyYXBpZSBJbm5v

dmF0aXZlIG5laSBMaW5mb21pKSBwcm9zcGVjdGl2ZSBtdWx0aWNlbnRlciB0cmlhbDwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5CbG9vZDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Qmxvb2Q8

L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CbG9vZDwvZnVsbC10

aXRsZT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJsb29kPC9mdWxs

LXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIzMTYtMjM8L3BhZ2VzPjx2b2x1bWU+MTEw

PC92b2x1bWU+PG51bWJlcj43PC9udW1iZXI+PGVkaXRpb24+MjAwNy8wNi8yMjwvZWRpdGlvbj48

a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48

a2V5d29yZD5BbnRpYm9kaWVzLCBNb25vY2xvbmFsL2FkdmVyc2UgZWZmZWN0cy8qdGhlcmFwZXV0

aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlib2RpZXMsIE1vbm9jbG9uYWwsIEh1bWFuaXpl

ZDwva2V5d29yZD48a2V5d29yZD5BbnRpYm9kaWVzLCBOZW9wbGFzbS9hZHZlcnNlIGVmZmVjdHMv

KnRoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5BbnRpZ2VucywgQ0QvbWV0YWJvbGlz

bTwva2V5d29yZD48a2V5d29yZD5BbnRpZ2VucywgTmVvcGxhc20vbWV0YWJvbGlzbTwva2V5d29y

ZD48a2V5d29yZD5BbnRpbmVvcGxhc3RpYyBDb21iaW5lZCBDaGVtb3RoZXJhcHkgUHJvdG9jb2xz

L2FkdmVyc2UgZWZmZWN0cy8qdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkN5Y2xv

cGhvc3BoYW1pZGUvYWR2ZXJzZSBlZmZlY3RzL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5

d29yZD5Eb3NlLVJlc3BvbnNlIFJlbGF0aW9uc2hpcCwgRHJ1Zzwva2V5d29yZD48a2V5d29yZD5E

b3hvcnViaWNpbi9hZHZlcnNlIGVmZmVjdHMvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3

b3JkPkdseWNvcHJvdGVpbnMvbWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+SXRhbHk8L2tleXdvcmQ+PGtleXdvcmQ+S2FwbGFuLU1laWVyIEVzdGlt

YXRlPC9rZXl3b3JkPjxrZXl3b3JkPkx5bXBob21hLCBULUNlbGwsIFBlcmlwaGVyYWwvKmRydWcg

dGhlcmFweS9tZXRhYm9saXNtLypwYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFn

ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXVsdGljZW50ZXIgU3R1ZGllcyBhcyBUb3BpYzwva2V5d29y

ZD48a2V5d29yZD5QcmVkbmlzb25lL2FkdmVyc2UgZWZmZWN0cy90aGVyYXBldXRpYyB1c2U8L2tl

eXdvcmQ+PGtleXdvcmQ+KlNvY2lldGllcywgTWVkaWNhbDwva2V5d29yZD48a2V5d29yZD5WaW5j

cmlzdGluZS9hZHZlcnNlIGVmZmVjdHMvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMDc8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5PY3QgMTwvZGF0ZT48

L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMDYtNDk3MSAoUHJpbnQpJiN4RDswMDA2LTQ5NzEg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE3NTgxOTE4PC9hY2Nlc3Npb24tbnVtPjx3

b3JrLXR5cGU+Q2xpbmljYWwgVHJpYWwmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdv

diZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5u

Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xNzU4MTkxODwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE4Mi9ibG9vZC0yMDA3LTAyLTA3NDY0MTwv

ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+

PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA [53, 54]. Tumor necrosis factor α (TNF-α) inhibitors are widely used for autoimmune diseases, and have been associated with an increased risk of infections and cancer PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb25nYXJ0ejwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+

PFJlY051bT4yNjQxNTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNTVdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjI2NDE1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNjQxNTwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Qm9uZ2FydHosIFQuPC9hdXRo

b3I+PGF1dGhvcj5TdXR0b24sIEEuIEouPC9hdXRob3I+PGF1dGhvcj5Td2VldGluZywgTS4gSi48

L2F1dGhvcj48YXV0aG9yPkJ1Y2hhbiwgSS48L2F1dGhvcj48YXV0aG9yPk1hdHRlc29uLCBFLiBM

LjwvYXV0aG9yPjxhdXRob3I+TW9udG9yaSwgVi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli

dXRvcnM+PGF1dGgtYWRkcmVzcz5EaXZpc2lvbiBvZiBSaGV1bWF0b2xvZ3kgYW5kIERlcGFydG1l

bnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUsIE1heW8gQ2xpbmljIENvbGxlZ2Ugb2YgTWVkaWNpbmUs

IFJvY2hlc3RlciwgTWlubiA1NTkwNSwgVVNBLiBib25nYXJ0ei50aW1AbWF5by5lZHU8L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5BbnRpLVRORiBhbnRpYm9keSB0aGVyYXB5IGluIHJoZXVt

YXRvaWQgYXJ0aHJpdGlzIGFuZCB0aGUgcmlzayBvZiBzZXJpb3VzIGluZmVjdGlvbnMgYW5kIG1h

bGlnbmFuY2llczogc3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXMgb2YgcmFyZSBo

YXJtZnVsIGVmZmVjdHMgaW4gcmFuZG9taXplZCBjb250cm9sbGVkIHRyaWFsczwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5KQU1BPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5KYW1hPC9hbHQt

dGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SkFNQTwvZnVsbC10aXRsZT48

L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpBTUE8L2Z1bGwtdGl0bGU+

PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjI3NS04NTwvcGFnZXM+PHZvbHVtZT4yOTU8L3ZvbHVt

ZT48bnVtYmVyPjE5PC9udW1iZXI+PGVkaXRpb24+MjAwNi8wNS8xODwvZWRpdGlvbj48a2V5d29y

ZHM+PGtleXdvcmQ+QW50aWJvZGllcywgTW9ub2Nsb25hbC9hZHZlcnNlIGVmZmVjdHMvKnRoZXJh

cGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5BbnRpYm9kaWVzLCBNb25vY2xvbmFsLCBIdW1h

bml6ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW50aXJoZXVtYXRpYyBBZ2VudHMvYWR2ZXJzZSBlZmZl

Y3RzLyp0aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QXJ0aHJpdGlzLCBSaGV1bWF0

b2lkLypkcnVnIHRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3

b3JkPkltbXVub2xvZ2ljIEZhY3RvcnMvYWR2ZXJzZSBlZmZlY3RzLyp0aGVyYXBldXRpYyB1c2U8

L2tleXdvcmQ+PGtleXdvcmQ+SW5mZWN0aW9uL2VwaWRlbWlvbG9neTwva2V5d29yZD48a2V5d29y

ZD5OZW9wbGFzbXMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJhbmRvbWl6ZWQgQ29u

dHJvbGxlZCBUcmlhbHMgYXMgVG9waWM8L2tleXdvcmQ+PGtleXdvcmQ+Umlzazwva2V5d29yZD48

a2V5d29yZD5UdW1vciBOZWNyb3NpcyBGYWN0b3ItYWxwaGEvKmFudGFnb25pc3RzICZhbXA7IGlu

aGliaXRvcnM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNjwveWVhcj48cHVi

LWRhdGVzPjxkYXRlPk1heSAxNzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1Mzgt

MzU5OCAoRWxlY3Ryb25pYykmI3hEOzAwOTgtNzQ4NCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MTY3MDUxMDk8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5NZXRhLUFuYWx5c2lzJiN4

RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0JiN4RDtSZXZpZXc8L3dvcmst

dHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8xNjcwNTEwOTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+MTAuMTAwMS9qYW1hLjI5NS4xOS4yMjc1PC9lbGVjdHJvbmljLXJlc291cmNl

LW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb25nYXJ0ejwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+

PFJlY051bT4yNjQxNTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNTVdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjI2NDE1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNjQxNTwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Qm9uZ2FydHosIFQuPC9hdXRo

b3I+PGF1dGhvcj5TdXR0b24sIEEuIEouPC9hdXRob3I+PGF1dGhvcj5Td2VldGluZywgTS4gSi48

L2F1dGhvcj48YXV0aG9yPkJ1Y2hhbiwgSS48L2F1dGhvcj48YXV0aG9yPk1hdHRlc29uLCBFLiBM

LjwvYXV0aG9yPjxhdXRob3I+TW9udG9yaSwgVi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli

dXRvcnM+PGF1dGgtYWRkcmVzcz5EaXZpc2lvbiBvZiBSaGV1bWF0b2xvZ3kgYW5kIERlcGFydG1l

bnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUsIE1heW8gQ2xpbmljIENvbGxlZ2Ugb2YgTWVkaWNpbmUs

IFJvY2hlc3RlciwgTWlubiA1NTkwNSwgVVNBLiBib25nYXJ0ei50aW1AbWF5by5lZHU8L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5BbnRpLVRORiBhbnRpYm9keSB0aGVyYXB5IGluIHJoZXVt

YXRvaWQgYXJ0aHJpdGlzIGFuZCB0aGUgcmlzayBvZiBzZXJpb3VzIGluZmVjdGlvbnMgYW5kIG1h

bGlnbmFuY2llczogc3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXMgb2YgcmFyZSBo

YXJtZnVsIGVmZmVjdHMgaW4gcmFuZG9taXplZCBjb250cm9sbGVkIHRyaWFsczwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5KQU1BPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5KYW1hPC9hbHQt

dGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SkFNQTwvZnVsbC10aXRsZT48

L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpBTUE8L2Z1bGwtdGl0bGU+

PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjI3NS04NTwvcGFnZXM+PHZvbHVtZT4yOTU8L3ZvbHVt

ZT48bnVtYmVyPjE5PC9udW1iZXI+PGVkaXRpb24+MjAwNi8wNS8xODwvZWRpdGlvbj48a2V5d29y

ZHM+PGtleXdvcmQ+QW50aWJvZGllcywgTW9ub2Nsb25hbC9hZHZlcnNlIGVmZmVjdHMvKnRoZXJh

cGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5BbnRpYm9kaWVzLCBNb25vY2xvbmFsLCBIdW1h

bml6ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW50aXJoZXVtYXRpYyBBZ2VudHMvYWR2ZXJzZSBlZmZl

Y3RzLyp0aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QXJ0aHJpdGlzLCBSaGV1bWF0

b2lkLypkcnVnIHRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3

b3JkPkltbXVub2xvZ2ljIEZhY3RvcnMvYWR2ZXJzZSBlZmZlY3RzLyp0aGVyYXBldXRpYyB1c2U8

L2tleXdvcmQ+PGtleXdvcmQ+SW5mZWN0aW9uL2VwaWRlbWlvbG9neTwva2V5d29yZD48a2V5d29y

ZD5OZW9wbGFzbXMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJhbmRvbWl6ZWQgQ29u

dHJvbGxlZCBUcmlhbHMgYXMgVG9waWM8L2tleXdvcmQ+PGtleXdvcmQ+Umlzazwva2V5d29yZD48

a2V5d29yZD5UdW1vciBOZWNyb3NpcyBGYWN0b3ItYWxwaGEvKmFudGFnb25pc3RzICZhbXA7IGlu

aGliaXRvcnM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNjwveWVhcj48cHVi

LWRhdGVzPjxkYXRlPk1heSAxNzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1Mzgt

MzU5OCAoRWxlY3Ryb25pYykmI3hEOzAwOTgtNzQ4NCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MTY3MDUxMDk8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5NZXRhLUFuYWx5c2lzJiN4

RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0JiN4RDtSZXZpZXc8L3dvcmst

dHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8xNjcwNTEwOTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+MTAuMTAwMS9qYW1hLjI5NS4xOS4yMjc1PC9lbGVjdHJvbmljLXJlc291cmNl

LW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [55]. An analysis of non-viral opportunistic infections in patients with autoimmune diseases documented the overall risk was greater in patients receiving TNF-α antagonists compared to non-biological disease-modifying antirheumatic drugs; however, IA was only observed in 1 of over 30,000 patients receiving a TNF-α antagonist PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWRkbGV5PC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

UmVjTnVtPjI2ODcwPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls1Nl08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MjY4NzA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI2ODcwPC9r

ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl

Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CYWRkbGV5LCBKLiBXLjwvYXV0

aG9yPjxhdXRob3I+V2ludGhyb3AsIEsuIEwuPC9hdXRob3I+PGF1dGhvcj5DaGVuLCBMLjwvYXV0

aG9yPjxhdXRob3I+TGl1LCBMLjwvYXV0aG9yPjxhdXRob3I+R3JpamFsdmEsIEMuIEcuPC9hdXRo

b3I+PGF1dGhvcj5EZWx6ZWxsLCBFLjwvYXV0aG9yPjxhdXRob3I+QmV1a2VsbWFuLCBULjwvYXV0

aG9yPjxhdXRob3I+UGF0a2FyLCBOLiBNLjwvYXV0aG9yPjxhdXRob3I+WGllLCBGLjwvYXV0aG9y

PjxhdXRob3I+U2FhZywgSy4gRy48L2F1dGhvcj48YXV0aG9yPkhlcnJpbnRvbiwgTC4gSi48L2F1

dGhvcj48YXV0aG9yPlNvbG9tb24sIEQuIEguPC9hdXRob3I+PGF1dGhvcj5MZXdpcywgSi4gRC48

L2F1dGhvcj48YXV0aG9yPkN1cnRpcywgSi4gUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli

dXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIE1lZGljaW5lLCBEaXZpc2lvbiBvZiBJ

bmZlY3Rpb3VzIERpc2Vhc2VzLCBVbml2ZXJzaXR5IG9mIEFsYWJhbWEgYXQgQmlybWluZ2hhbSwg

QmlybWluZ2hhbSwgQWxhYmFtYSwgVVNBIE1lZGljYWwgU2VydmljZSwgQmlybWluZ2hhbSBWQSBN

ZWRpY2FsIENlbnRlciwgQmlybWluZ2hhbSwgQWxhYmFtYSwgVVNBLiYjeEQ7RGVwYXJ0bWVudCBv

ZiBNZWRpY2luZSwgT3JlZ29uIEhlYWx0aCBhbmQgU2NpZW5jZSBVbml2ZXJzaXR5LCBQb3J0bGFu

ZCwgT3JlZ29uLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBEaXZpc2lvbiBvZiBJ

bmZlY3Rpb3VzIERpc2Vhc2VzLCBVbml2ZXJzaXR5IG9mIEFsYWJhbWEgYXQgQmlybWluZ2hhbSwg

QmlybWluZ2hhbSwgQWxhYmFtYSwgVVNBLiYjeEQ7RGl2aXNpb24gb2YgUmVzZWFyY2gsIEthaXNl

ciBQZXJtYW5lbnRlIE5vcnRoZXJuIENhbGlmb3JuaWEsIE9ha2xhbmQsIENhbGlmb3JuaWEsIFVT

QS4mI3hEO0RlcGFydG1lbnQgb2YgTWVkaWNpbmUsIFZhbmRlcmJpbHQgVW5pdmVyc2l0eSwgTmFz

aHZpbGxlLCBUZW5uZXNzZWUsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgTWVkaWNpbmUsIEJvc3Rv

biwgQnJpZ2hhbSBhbmQgV29tZW4mYXBvcztzIEhvc3BpdGFsLUhhcnZhcmQgVW5pdmVyc2l0eSwg

Qm9zdG9uLCBNYXNzYWNodXNldHRzLCBVU0EuJiN4RDtDZW50ZXIgZm9yIENsaW5pY2FsIEVwaWRl

bWlvbG9neSBhbmQgQmlvc3RhdGlzdGljcywgUGVybG1hbiBTY2hvb2wgb2YgTWVkaWNpbmUgYXQg

dGhlIFVuaXZlcnNpdHkgb2YgUGVubnN5bHZhbmlhLCBQaGlsYWRlbHBoaWEsIFBlbm5zeWx2YW5p

YSwgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk5vbi12aXJhbCBvcHBvcnR1bmlz

dGljIGluZmVjdGlvbnMgaW4gbmV3IHVzZXJzIG9mIHR1bW91ciBuZWNyb3NpcyBmYWN0b3IgaW5o

aWJpdG9yIHRoZXJhcHk6IHJlc3VsdHMgb2YgdGhlIFNBZmV0eSBBc3Nlc3NtZW50IG9mIEJpb2xv

Z2ljIFRoRVJhcHkgKFNBQkVSKSBTdHVkeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Bbm4gUmhl

dW0gRGlzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Bbm5hbHMgb2YgdGhlIHJoZXVtYXRp

YyBkaXNlYXNlczwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFu

biBSaGV1bSBEaXM8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4xOTQyLTg8L3BhZ2Vz

Pjx2b2x1bWU+NzM8L3ZvbHVtZT48bnVtYmVyPjExPC9udW1iZXI+PGVkaXRpb24+MjAxMy8wNy8x

NjwvZWRpdGlvbj48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48cHViLWRhdGVzPjxkYXRlPk5vdjwv

ZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0NjgtMjA2MCAoRWxlY3Ryb25pYykmI3hE

OzAwMDMtNDk2NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjM4NTI3NjM8L2FjY2Vz

c2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmlo

Lmdvdi9wdWJtZWQvMjM4NTI3NjM8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjEwLjExMzYvYW5ucmhldW1kaXMtMjAxMy0yMDM0MDc8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48

L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWRkbGV5PC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

UmVjTnVtPjI2ODcwPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls1Nl08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MjY4NzA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI2ODcwPC9r

ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl

Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CYWRkbGV5LCBKLiBXLjwvYXV0

aG9yPjxhdXRob3I+V2ludGhyb3AsIEsuIEwuPC9hdXRob3I+PGF1dGhvcj5DaGVuLCBMLjwvYXV0

aG9yPjxhdXRob3I+TGl1LCBMLjwvYXV0aG9yPjxhdXRob3I+R3JpamFsdmEsIEMuIEcuPC9hdXRo

b3I+PGF1dGhvcj5EZWx6ZWxsLCBFLjwvYXV0aG9yPjxhdXRob3I+QmV1a2VsbWFuLCBULjwvYXV0

aG9yPjxhdXRob3I+UGF0a2FyLCBOLiBNLjwvYXV0aG9yPjxhdXRob3I+WGllLCBGLjwvYXV0aG9y

PjxhdXRob3I+U2FhZywgSy4gRy48L2F1dGhvcj48YXV0aG9yPkhlcnJpbnRvbiwgTC4gSi48L2F1

dGhvcj48YXV0aG9yPlNvbG9tb24sIEQuIEguPC9hdXRob3I+PGF1dGhvcj5MZXdpcywgSi4gRC48

L2F1dGhvcj48YXV0aG9yPkN1cnRpcywgSi4gUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli

dXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIE1lZGljaW5lLCBEaXZpc2lvbiBvZiBJ

bmZlY3Rpb3VzIERpc2Vhc2VzLCBVbml2ZXJzaXR5IG9mIEFsYWJhbWEgYXQgQmlybWluZ2hhbSwg

QmlybWluZ2hhbSwgQWxhYmFtYSwgVVNBIE1lZGljYWwgU2VydmljZSwgQmlybWluZ2hhbSBWQSBN

ZWRpY2FsIENlbnRlciwgQmlybWluZ2hhbSwgQWxhYmFtYSwgVVNBLiYjeEQ7RGVwYXJ0bWVudCBv

ZiBNZWRpY2luZSwgT3JlZ29uIEhlYWx0aCBhbmQgU2NpZW5jZSBVbml2ZXJzaXR5LCBQb3J0bGFu

ZCwgT3JlZ29uLCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBEaXZpc2lvbiBvZiBJ

bmZlY3Rpb3VzIERpc2Vhc2VzLCBVbml2ZXJzaXR5IG9mIEFsYWJhbWEgYXQgQmlybWluZ2hhbSwg

QmlybWluZ2hhbSwgQWxhYmFtYSwgVVNBLiYjeEQ7RGl2aXNpb24gb2YgUmVzZWFyY2gsIEthaXNl

ciBQZXJtYW5lbnRlIE5vcnRoZXJuIENhbGlmb3JuaWEsIE9ha2xhbmQsIENhbGlmb3JuaWEsIFVT

QS4mI3hEO0RlcGFydG1lbnQgb2YgTWVkaWNpbmUsIFZhbmRlcmJpbHQgVW5pdmVyc2l0eSwgTmFz

aHZpbGxlLCBUZW5uZXNzZWUsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgTWVkaWNpbmUsIEJvc3Rv

biwgQnJpZ2hhbSBhbmQgV29tZW4mYXBvcztzIEhvc3BpdGFsLUhhcnZhcmQgVW5pdmVyc2l0eSwg

Qm9zdG9uLCBNYXNzYWNodXNldHRzLCBVU0EuJiN4RDtDZW50ZXIgZm9yIENsaW5pY2FsIEVwaWRl

bWlvbG9neSBhbmQgQmlvc3RhdGlzdGljcywgUGVybG1hbiBTY2hvb2wgb2YgTWVkaWNpbmUgYXQg

dGhlIFVuaXZlcnNpdHkgb2YgUGVubnN5bHZhbmlhLCBQaGlsYWRlbHBoaWEsIFBlbm5zeWx2YW5p

YSwgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk5vbi12aXJhbCBvcHBvcnR1bmlz

dGljIGluZmVjdGlvbnMgaW4gbmV3IHVzZXJzIG9mIHR1bW91ciBuZWNyb3NpcyBmYWN0b3IgaW5o

aWJpdG9yIHRoZXJhcHk6IHJlc3VsdHMgb2YgdGhlIFNBZmV0eSBBc3Nlc3NtZW50IG9mIEJpb2xv

Z2ljIFRoRVJhcHkgKFNBQkVSKSBTdHVkeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Bbm4gUmhl

dW0gRGlzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Bbm5hbHMgb2YgdGhlIHJoZXVtYXRp

YyBkaXNlYXNlczwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFu

biBSaGV1bSBEaXM8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4xOTQyLTg8L3BhZ2Vz

Pjx2b2x1bWU+NzM8L3ZvbHVtZT48bnVtYmVyPjExPC9udW1iZXI+PGVkaXRpb24+MjAxMy8wNy8x

NjwvZWRpdGlvbj48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48cHViLWRhdGVzPjxkYXRlPk5vdjwv

ZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0NjgtMjA2MCAoRWxlY3Ryb25pYykmI3hE

OzAwMDMtNDk2NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjM4NTI3NjM8L2FjY2Vz

c2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmlo

Lmdvdi9wdWJtZWQvMjM4NTI3NjM8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjEwLjExMzYvYW5ucmhldW1kaXMtMjAxMy0yMDM0MDc8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48

L0VuZE5vdGU+

ADDIN EN.CITE.DATA [56]. By contrast, the use of infliximab for severe GVHD is associated with high risk for the development of IA PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJ0eTwvQXV0aG9yPjxZZWFyPjIwMDM8L1llYXI+PFJl

Y051bT4yNTk1MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNTddPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjI1OTUxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNTk1MTwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFydHksIEYuIE0uPC9hdXRob3I+

PGF1dGhvcj5MZWUsIFMuIEouPC9hdXRob3I+PGF1dGhvcj5GYWhleSwgTS4gTS48L2F1dGhvcj48

YXV0aG9yPkFseWVhLCBFLiBQLjwvYXV0aG9yPjxhdXRob3I+U29pZmZlciwgUi4gSi48L2F1dGhv

cj48YXV0aG9yPkFudGluLCBKLiBILjwvYXV0aG9yPjxhdXRob3I+QmFkZW4sIEwuIFIuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGl2aXNpb24gb2YgSW5m

ZWN0aW91cyBEaXNlYXNlcyBhbmQgSGVtYXRvcG9pZXRpYyBTdGVtLUNlbGwgVHJhbnNwYWxudGF0

aW9uIFNlcnZpY2UsIEJyaWdoYW0gYW5kIFdvbWVuJmFwb3M7cyBIb3NwaXRhbCBhbmQgRGFuYS1G

YXJiZXIgQ2FuY2VyIEluc3RpdXRlLCBIYXJ2YXJkIE1lZGljYWwgU2Nob29sLCBCb3N0b24sIE1B

IDAyMTE1LCBVU0EuIGZtYXJ0eUBwYXJ0bmVycy5vcmc8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0

aXRsZT5JbmZsaXhpbWFiIHVzZSBpbiBwYXRpZW50cyB3aXRoIHNldmVyZSBncmFmdC12ZXJzdXMt

aG9zdCBkaXNlYXNlIGFuZCBvdGhlciBlbWVyZ2luZyByaXNrIGZhY3RvcnMgb2Ygbm9uLUNhbmRp

ZGEgaW52YXNpdmUgZnVuZ2FsIGluZmVjdGlvbnMgaW4gYWxsb2dlbmVpYyBoZW1hdG9wb2lldGlj

IHN0ZW0gY2VsbCB0cmFuc3BsYW50IHJlY2lwaWVudHM6IGEgY29ob3J0IHN0dWR5PC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkJsb29kPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5CbG9vZDwv

YWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJsb29kPC9mdWxsLXRp

dGxlPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Qmxvb2Q8L2Z1bGwt

dGl0bGU+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+Mjc2OC03NjwvcGFnZXM+PHZvbHVtZT4xMDI8

L3ZvbHVtZT48bnVtYmVyPjg8L251bWJlcj48ZWRpdGlvbj4yMDAzLzA3LzEyPC9lZGl0aW9uPjxr

ZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3

b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWJvZGllcywgTW9ub2Nsb25h

bC8qdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkNvaG9ydCBTdHVkaWVzPC9rZXl3

b3JkPjxrZXl3b3JkPkRlcm1hdG9sb2dpYyBBZ2VudHMvKnRoZXJhcGV1dGljIHVzZTwva2V5d29y

ZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+R3JhZnQgdnMgSG9zdCBEaXNlYXNl

LypkcnVnIHRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvcG9pZXRpYyBTdGVtIENlbGwg

VHJhbnNwbGFudGF0aW9uLyphZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z

PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tl

eXdvcmQ+PGtleXdvcmQ+TXVsdGl2YXJpYXRlIEFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPk15

Y29zZXMvKmV0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJpc2s8L2tleXdvcmQ+PGtleXdvcmQ+

UmlzayBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48a2V5

d29yZD5UcmFuc3BsYW50YXRpb24sIEhvbW9sb2dvdXMvKmFkdmVyc2UgZWZmZWN0czwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+T2N0

IDE1PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAwNi00OTcxIChQcmludCkmI3hE

OzAwMDYtNDk3MSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTI4NTU1ODM8L2FjY2Vz

c2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmlo

Lmdvdi9wdWJtZWQvMTI4NTU1ODM8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjEwLjExODIvYmxvb2QtMjAwMy0wMS0wMjY3PC9lbGVjdHJvbmljLXJl

c291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmRO

b3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJ0eTwvQXV0aG9yPjxZZWFyPjIwMDM8L1llYXI+PFJl

Y051bT4yNTk1MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNTddPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjI1OTUxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNTk1MTwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFydHksIEYuIE0uPC9hdXRob3I+

PGF1dGhvcj5MZWUsIFMuIEouPC9hdXRob3I+PGF1dGhvcj5GYWhleSwgTS4gTS48L2F1dGhvcj48

YXV0aG9yPkFseWVhLCBFLiBQLjwvYXV0aG9yPjxhdXRob3I+U29pZmZlciwgUi4gSi48L2F1dGhv

cj48YXV0aG9yPkFudGluLCBKLiBILjwvYXV0aG9yPjxhdXRob3I+QmFkZW4sIEwuIFIuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGl2aXNpb24gb2YgSW5m

ZWN0aW91cyBEaXNlYXNlcyBhbmQgSGVtYXRvcG9pZXRpYyBTdGVtLUNlbGwgVHJhbnNwYWxudGF0

aW9uIFNlcnZpY2UsIEJyaWdoYW0gYW5kIFdvbWVuJmFwb3M7cyBIb3NwaXRhbCBhbmQgRGFuYS1G

YXJiZXIgQ2FuY2VyIEluc3RpdXRlLCBIYXJ2YXJkIE1lZGljYWwgU2Nob29sLCBCb3N0b24sIE1B

IDAyMTE1LCBVU0EuIGZtYXJ0eUBwYXJ0bmVycy5vcmc8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0

aXRsZT5JbmZsaXhpbWFiIHVzZSBpbiBwYXRpZW50cyB3aXRoIHNldmVyZSBncmFmdC12ZXJzdXMt

aG9zdCBkaXNlYXNlIGFuZCBvdGhlciBlbWVyZ2luZyByaXNrIGZhY3RvcnMgb2Ygbm9uLUNhbmRp

ZGEgaW52YXNpdmUgZnVuZ2FsIGluZmVjdGlvbnMgaW4gYWxsb2dlbmVpYyBoZW1hdG9wb2lldGlj

IHN0ZW0gY2VsbCB0cmFuc3BsYW50IHJlY2lwaWVudHM6IGEgY29ob3J0IHN0dWR5PC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkJsb29kPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5CbG9vZDwv

YWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJsb29kPC9mdWxsLXRp

dGxlPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Qmxvb2Q8L2Z1bGwt

dGl0bGU+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+Mjc2OC03NjwvcGFnZXM+PHZvbHVtZT4xMDI8

L3ZvbHVtZT48bnVtYmVyPjg8L251bWJlcj48ZWRpdGlvbj4yMDAzLzA3LzEyPC9lZGl0aW9uPjxr

ZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3

b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWJvZGllcywgTW9ub2Nsb25h

bC8qdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkNvaG9ydCBTdHVkaWVzPC9rZXl3

b3JkPjxrZXl3b3JkPkRlcm1hdG9sb2dpYyBBZ2VudHMvKnRoZXJhcGV1dGljIHVzZTwva2V5d29y

ZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+R3JhZnQgdnMgSG9zdCBEaXNlYXNl

LypkcnVnIHRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvcG9pZXRpYyBTdGVtIENlbGwg

VHJhbnNwbGFudGF0aW9uLyphZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z

PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tl

eXdvcmQ+PGtleXdvcmQ+TXVsdGl2YXJpYXRlIEFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPk15

Y29zZXMvKmV0aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJpc2s8L2tleXdvcmQ+PGtleXdvcmQ+

UmlzayBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48a2V5

d29yZD5UcmFuc3BsYW50YXRpb24sIEhvbW9sb2dvdXMvKmFkdmVyc2UgZWZmZWN0czwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+T2N0

IDE1PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAwNi00OTcxIChQcmludCkmI3hE

OzAwMDYtNDk3MSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTI4NTU1ODM8L2FjY2Vz

c2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmlo

Lmdvdi9wdWJtZWQvMTI4NTU1ODM8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjEwLjExODIvYmxvb2QtMjAwMy0wMS0wMjY3PC9lbGVjdHJvbmljLXJl

c291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmRO

b3RlPn==

ADDIN EN.CITE.DATA [57]. Therefore, in assessing the risk for aspergillosis from a specific drug or antibody, one must consider all relevant factors, including the underlying disease being treated, comorbidities (e.g., pre-existing lung disease), neutropenia, and the use of concurrent immunosuppressive agents. IA has also been recognized in critically ill patients without traditional risk factors. The exact proportion of critically ill patients with IA in the absence of other risk factors is difficult to determine. In a retrospective analysis, Meersseman et al. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZWVyc3NlbWFuPC9BdXRob3I+PFllYXI+MjAwNDwvWWVh

cj48UmVjTnVtPjI2ODAxPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls1OF08L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MjY4MDE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI2ODAx

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NZWVyc3NlbWFuLCBXLjwv

YXV0aG9yPjxhdXRob3I+VmFuZGVjYXN0ZWVsZSwgUy4gSi48L2F1dGhvcj48YXV0aG9yPldpbG1l

ciwgQS48L2F1dGhvcj48YXV0aG9yPlZlcmJla2VuLCBFLjwvYXV0aG9yPjxhdXRob3I+UGVldGVy

bWFucywgVy4gRS48L2F1dGhvcj48YXV0aG9yPlZhbiBXaWpuZ2FlcmRlbiwgRS48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NZWRpY2FsIEludGVuc2l2ZSBD

YXJlIFVuaXQsIERlcGFydG1lbnQgb2YgR2VuZXJhbCBJbnRlcm5hbCBNZWRpY2luZSwgVW5pdmVy

c2l0eSBIb3NwaXRhbCwgTGV1dmVuLCBCZWxnaXVtLiB3b3V0ZXIubWVlcnNzZW1hbkB1ei5rdWxl

dXZlbi5hYy5iZTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkludmFzaXZlIGFzcGVyZ2ls

bG9zaXMgaW4gY3JpdGljYWxseSBpbGwgcGF0aWVudHMgd2l0aG91dCBtYWxpZ25hbmN5PC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPkFtIEogUmVzcGlyIENyaXQgQ2FyZSBNZWQ8L3NlY29uZGFyeS10

aXRsZT48YWx0LXRpdGxlPkFtZXJpY2FuIGpvdXJuYWwgb2YgcmVzcGlyYXRvcnkgYW5kIGNyaXRp

Y2FsIGNhcmUgbWVkaWNpbmU8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5BbSBKIFJlc3BpciBDcml0IENhcmUgTWVkPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48

cGFnZXM+NjIxLTU8L3BhZ2VzPjx2b2x1bWU+MTcwPC92b2x1bWU+PG51bWJlcj42PC9udW1iZXI+

PGVkaXRpb24+MjAwNC8wNy8wMjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5

d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2NvbXBsaWNhdGlvbnMvKmRpYWdub3Npcy9tb3J0

YWxpdHk8L2tleXdvcmQ+PGtleXdvcmQ+QmVsZ2l1bS9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtl

eXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+Q3JpdGljYWwgSWxsbmVzcy8q

bW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1h

bnM8L2tleXdvcmQ+PGtleXdvcmQ+SW50ZW5zaXZlIENhcmUgVW5pdHMvc3RhdGlzdGljcyAmYW1w

OyBudW1lcmljYWwgZGF0YTwva2V5d29yZD48a2V5d29yZD5MaXZlciBDaXJyaG9zaXMvKmNvbXBs

aWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUg

QWdlZDwva2V5d29yZD48a2V5d29yZD5OZW9wbGFzbXM8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9z

cGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48

L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+U2VwIDE1

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA3My00NDlYIChQcmludCkmI3hEOzEw

NzMtNDQ5WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTUyMjkwOTQ8L2FjY2Vzc2lv

bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMTUyMjkwOTQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPjEwLjExNjQvcmNjbS4yMDA0MDEtMDkzT0M8L2VsZWN0cm9uaWMtcmVzb3Vy

Y2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZWVyc3NlbWFuPC9BdXRob3I+PFllYXI+MjAwNDwvWWVh

cj48UmVjTnVtPjI2ODAxPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls1OF08L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MjY4MDE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSJhOWEwemR3czlzOTBhdmU5eHJteHRmOWg5MHB3MmR4enB0ZXAiPjI2ODAx

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NZWVyc3NlbWFuLCBXLjwv

YXV0aG9yPjxhdXRob3I+VmFuZGVjYXN0ZWVsZSwgUy4gSi48L2F1dGhvcj48YXV0aG9yPldpbG1l

ciwgQS48L2F1dGhvcj48YXV0aG9yPlZlcmJla2VuLCBFLjwvYXV0aG9yPjxhdXRob3I+UGVldGVy

bWFucywgVy4gRS48L2F1dGhvcj48YXV0aG9yPlZhbiBXaWpuZ2FlcmRlbiwgRS48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NZWRpY2FsIEludGVuc2l2ZSBD

YXJlIFVuaXQsIERlcGFydG1lbnQgb2YgR2VuZXJhbCBJbnRlcm5hbCBNZWRpY2luZSwgVW5pdmVy

c2l0eSBIb3NwaXRhbCwgTGV1dmVuLCBCZWxnaXVtLiB3b3V0ZXIubWVlcnNzZW1hbkB1ei5rdWxl

dXZlbi5hYy5iZTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkludmFzaXZlIGFzcGVyZ2ls

bG9zaXMgaW4gY3JpdGljYWxseSBpbGwgcGF0aWVudHMgd2l0aG91dCBtYWxpZ25hbmN5PC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPkFtIEogUmVzcGlyIENyaXQgQ2FyZSBNZWQ8L3NlY29uZGFyeS10

aXRsZT48YWx0LXRpdGxlPkFtZXJpY2FuIGpvdXJuYWwgb2YgcmVzcGlyYXRvcnkgYW5kIGNyaXRp

Y2FsIGNhcmUgbWVkaWNpbmU8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5BbSBKIFJlc3BpciBDcml0IENhcmUgTWVkPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48

cGFnZXM+NjIxLTU8L3BhZ2VzPjx2b2x1bWU+MTcwPC92b2x1bWU+PG51bWJlcj42PC9udW1iZXI+

PGVkaXRpb24+MjAwNC8wNy8wMjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5

d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2NvbXBsaWNhdGlvbnMvKmRpYWdub3Npcy9tb3J0

YWxpdHk8L2tleXdvcmQ+PGtleXdvcmQ+QmVsZ2l1bS9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtl

eXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+Q3JpdGljYWwgSWxsbmVzcy8q

bW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1h

bnM8L2tleXdvcmQ+PGtleXdvcmQ+SW50ZW5zaXZlIENhcmUgVW5pdHMvc3RhdGlzdGljcyAmYW1w

OyBudW1lcmljYWwgZGF0YTwva2V5d29yZD48a2V5d29yZD5MaXZlciBDaXJyaG9zaXMvKmNvbXBs

aWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUg

QWdlZDwva2V5d29yZD48a2V5d29yZD5OZW9wbGFzbXM8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9z

cGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48

L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+U2VwIDE1

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA3My00NDlYIChQcmludCkmI3hEOzEw

NzMtNDQ5WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTUyMjkwOTQ8L2FjY2Vzc2lv

bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMTUyMjkwOTQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPjEwLjExNjQvcmNjbS4yMDA0MDEtMDkzT0M8L2VsZWN0cm9uaWMtcmVzb3Vy

Y2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [58] identified 127 patients out of 1,850 intensive care unit (ICU) admissions (6.9%) with microbiological or histopathologic evidence of Aspergillus infection; however, only 5 of these patients had proven IA without predisposing host factors. Trials that evaluate clinical approaches to diagnose IA in critically ill patients include a substantial proportion with classic risk factors for IA and other risk factors including chronic obstructive pulmonary disease (COPD) and cirrhosis PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CbG90PC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

TnVtPjI2ODAzPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls1OSwgNjBdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjI2ODAzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNjgwMzwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QmxvdCwgUy4gSS48L2F1dGhv

cj48YXV0aG9yPlRhY2NvbmUsIEYuIFMuPC9hdXRob3I+PGF1dGhvcj5WYW4gZGVuIEFiZWVsZSwg

QS4gTS48L2F1dGhvcj48YXV0aG9yPkJ1bHBhLCBQLjwvYXV0aG9yPjxhdXRob3I+TWVlcnNzZW1h

biwgVy48L2F1dGhvcj48YXV0aG9yPkJydXNzZWxhZXJzLCBOLjwvYXV0aG9yPjxhdXRob3I+RGlt

b3BvdWxvcywgRy48L2F1dGhvcj48YXV0aG9yPlBhaXZhLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+

TWlzc2V0LCBCLjwvYXV0aG9yPjxhdXRob3I+UmVsbG8sIEouPC9hdXRob3I+PGF1dGhvcj5WYW5k

ZXdvdWRlLCBLLjwvYXV0aG9yPjxhdXRob3I+Vm9nZWxhZXJzLCBELjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkdlbmVyYWwgSW50ZXJuYWwgTWVkaWNpbmUg

YW5kIEluZmVjdGlvdXMgRGlzZWFzZXMsIEdoZW50IFVuaXZlcnNpdHkgSG9zcGl0YWwsIERlIFBp

bnRlbGFhbiAxODUsIEdoZW50LCBCZWxnaXVtLiBzdGlqbi5ibG90QHVnZW50LmJlPC9hdXRoLWFk

ZHJlc3M+PHRpdGxlcz48dGl0bGU+QSBjbGluaWNhbCBhbGdvcml0aG0gdG8gZGlhZ25vc2UgaW52

YXNpdmUgcHVsbW9uYXJ5IGFzcGVyZ2lsbG9zaXMgaW4gY3JpdGljYWxseSBpbGwgcGF0aWVudHM8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW0gSiBSZXNwaXIgQ3JpdCBDYXJlIE1lZDwvc2Vjb25k

YXJ5LXRpdGxlPjxhbHQtdGl0bGU+QW1lcmljYW4gam91cm5hbCBvZiByZXNwaXJhdG9yeSBhbmQg

Y3JpdGljYWwgY2FyZSBtZWRpY2luZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkFtIEogUmVzcGlyIENyaXQgQ2FyZSBNZWQ8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp

Y2FsPjxwYWdlcz41Ni02NDwvcGFnZXM+PHZvbHVtZT4xODY8L3ZvbHVtZT48bnVtYmVyPjE8L251

bWJlcj48ZWRpdGlvbj4yMDEyLzA0LzIxPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD4qQWxn

b3JpdGhtczwva2V5d29yZD48a2V5d29yZD5Db21vcmJpZGl0eTwva2V5d29yZD48a2V5d29yZD5D

cml0aWNhbCBJbGxuZXNzPC9rZXl3b3JkPjxrZXl3b3JkPkRpYWJldGVzIE1lbGxpdHVzL2VwaWRl

bWlvbG9neTwva2V5d29yZD48a2V5d29yZD5IZWFydCBEaXNlYXNlcy9lcGlkZW1pb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+SGVhcnQgRmFpbHVyZS9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub2NvbXByb21pc2VkIEhvc3Q8L2tleXdv

cmQ+PGtleXdvcmQ+SW50ZW5zaXZlIENhcmUgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+UHVsbW9u

YXJ5IEFzcGVyZ2lsbG9zaXMvKmRpYWdub3Npcy9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdv

cmQ+UmVzcGlyYXRvcnkgVHJhY3QgRGlzZWFzZXMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3

b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDEyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVsIDE8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xNTM1LTQ5NzAgKEVsZWN0cm9uaWMpJiN4RDsxMDczLTQ0OVggKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyNTE3Nzg4PC9hY2Nlc3Npb24tbnVtPjx3b3Jr

LXR5cGU+TXVsdGljZW50ZXIgU3R1ZHkmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdv

diZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5u

Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMjUxNzc4ODwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE2NC9yY2NtLjIwMTExMS0xOTc4T0M8L2Vs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPk1lZXJzc2VtYW48L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+MjU2MTc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI1NjE3PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0

ZjloOTBwdzJkeHpwdGVwIj4yNTYxNzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l

PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh

dXRob3I+TWVlcnNzZW1hbiwgVy48L2F1dGhvcj48YXV0aG9yPkxhZ3JvdSwgSy48L2F1dGhvcj48

YXV0aG9yPk1hZXJ0ZW5zLCBKLjwvYXV0aG9yPjxhdXRob3I+V2lsbWVyLCBBLjwvYXV0aG9yPjxh

dXRob3I+SGVybWFucywgRy48L2F1dGhvcj48YXV0aG9yPlZhbmRlcnNjaHVlcmVuLCBTLjwvYXV0

aG9yPjxhdXRob3I+U3ByaWV0LCBJLjwvYXV0aG9yPjxhdXRob3I+VmVyYmVrZW4sIEUuPC9hdXRo

b3I+PGF1dGhvcj5WYW4gV2lqbmdhZXJkZW4sIEUuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp

YnV0b3JzPjxhdXRoLWFkZHJlc3M+TWVkaWNhbCBJbnRlbnNpdmUgQ2FyZSBVbml0LCBVbml2ZXJz

aXR5IEhvc3BpdGFsIExldXZlbiwgSGVyZXN0cmFhdCA0OSwgQi0zMDAwIExldXZlbiwgQmVsZ2l1

bS4gd291dGVyLm1lZXJzc2VtYW5AdXoua3VsZXV2ZW4uYWMuYmU8L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5HYWxhY3RvbWFubmFuIGluIGJyb25jaG9hbHZlb2xhciBsYXZhZ2UgZmx1aWQ6

IGEgdG9vbCBmb3IgZGlhZ25vc2luZyBhc3BlcmdpbGxvc2lzIGluIGludGVuc2l2ZSBjYXJlIHVu

aXQgcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW0gSiBSZXNwaXIgQ3JpdCBDYXJl

IE1lZDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QW1lcmljYW4gam91cm5hbCBvZiByZXNw

aXJhdG9yeSBhbmQgY3JpdGljYWwgY2FyZSBtZWRpY2luZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtIEogUmVzcGlyIENyaXQgQ2FyZSBNZWQ8L2Z1bGwtdGl0

bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4yNy0zNDwvcGFnZXM+PHZvbHVtZT4xNzc8L3ZvbHVtZT48

bnVtYmVyPjE8L251bWJlcj48ZWRpdGlvbj4yMDA3LzA5LzIyPC9lZGl0aW9uPjxrZXl3b3Jkcz48

a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFz

cGVyZ2lsbG9zaXMvZGlhZ25vc2lzLyptaWNyb2Jpb2xvZ3kvbW9ydGFsaXR5L3BhdGhvbG9neTwv

a2V5d29yZD48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkLyptaWNyb2Jpb2xv

Z3k8L2tleXdvcmQ+PGtleXdvcmQ+QnJvbmNob3Njb3B5PC9rZXl3b3JkPjxrZXl3b3JkPkNhdXNl

IG9mIERlYXRoPC9rZXl3b3JkPjxrZXl3b3JkPkNyb3NzIEluZmVjdGlvbi9kaWFnbm9zaXMvbWlj

cm9iaW9sb2d5L21vcnRhbGl0eS9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RGlhZ25vc2lz

LCBEaWZmZXJlbnRpYWw8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3Jk

Pkhvc3BpdGFsIE1vcnRhbGl0eTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+SW50ZW5zaXZlIENhcmUgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZy9taWNyb2Jp

b2xvZ3kvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcgRGlzZWFzZXMsIEZ1bmdhbC9k

aWFnbm9zaXMvKm1pY3JvYmlvbG9neS9tb3J0YWxpdHkvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3

b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8qYmxvb2Q8L2tleXdvcmQ+PGtleXdv

cmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXljb2xvZ2ljYWwgVHlwaW5nIFRlY2hu

aXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+T3Bwb3J0dW5pc3RpYyBJbmZlY3Rpb25zL2RpYWdub3Np

cy9taWNyb2Jpb2xvZ3kvbW9ydGFsaXR5L3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5QbmV1

bW9uaWEsIFZlbnRpbGF0b3ItQXNzb2NpYXRlZC9kaWFnbm9zaXMvKm1pY3JvYmlvbG9neS9tb3J0

YWxpdHkvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlByZWRpY3RpdmUgVmFsdWUgb2YgVGVz

dHM8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29y

ZD5TdXJ2aXZhbCBSYXRlPC9rZXl3b3JkPjxrZXl3b3JkPlRvbW9ncmFwaHksIFgtUmF5IENvbXB1

dGVkPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDg8L3llYXI+PHB1Yi1kYXRl

cz48ZGF0ZT5KYW4gMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzUtNDk3MCAo

RWxlY3Ryb25pYykmI3hEOzEwNzMtNDQ5WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+

MTc4ODUyNjQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93

d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTc4ODUyNjQ8L3VybD48L3JlbGF0ZWQtdXJscz48

L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExNjQvcmNjbS4yMDA3MDQtNjA2T0M8

L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3Jk

PjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CbG90PC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

TnVtPjI2ODAzPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls1OSwgNjBdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjI2ODAzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNjgwMzwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QmxvdCwgUy4gSS48L2F1dGhv

cj48YXV0aG9yPlRhY2NvbmUsIEYuIFMuPC9hdXRob3I+PGF1dGhvcj5WYW4gZGVuIEFiZWVsZSwg

QS4gTS48L2F1dGhvcj48YXV0aG9yPkJ1bHBhLCBQLjwvYXV0aG9yPjxhdXRob3I+TWVlcnNzZW1h

biwgVy48L2F1dGhvcj48YXV0aG9yPkJydXNzZWxhZXJzLCBOLjwvYXV0aG9yPjxhdXRob3I+RGlt

b3BvdWxvcywgRy48L2F1dGhvcj48YXV0aG9yPlBhaXZhLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+

TWlzc2V0LCBCLjwvYXV0aG9yPjxhdXRob3I+UmVsbG8sIEouPC9hdXRob3I+PGF1dGhvcj5WYW5k

ZXdvdWRlLCBLLjwvYXV0aG9yPjxhdXRob3I+Vm9nZWxhZXJzLCBELjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkdlbmVyYWwgSW50ZXJuYWwgTWVkaWNpbmUg

YW5kIEluZmVjdGlvdXMgRGlzZWFzZXMsIEdoZW50IFVuaXZlcnNpdHkgSG9zcGl0YWwsIERlIFBp

bnRlbGFhbiAxODUsIEdoZW50LCBCZWxnaXVtLiBzdGlqbi5ibG90QHVnZW50LmJlPC9hdXRoLWFk

ZHJlc3M+PHRpdGxlcz48dGl0bGU+QSBjbGluaWNhbCBhbGdvcml0aG0gdG8gZGlhZ25vc2UgaW52

YXNpdmUgcHVsbW9uYXJ5IGFzcGVyZ2lsbG9zaXMgaW4gY3JpdGljYWxseSBpbGwgcGF0aWVudHM8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW0gSiBSZXNwaXIgQ3JpdCBDYXJlIE1lZDwvc2Vjb25k

YXJ5LXRpdGxlPjxhbHQtdGl0bGU+QW1lcmljYW4gam91cm5hbCBvZiByZXNwaXJhdG9yeSBhbmQg

Y3JpdGljYWwgY2FyZSBtZWRpY2luZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkFtIEogUmVzcGlyIENyaXQgQ2FyZSBNZWQ8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp

Y2FsPjxwYWdlcz41Ni02NDwvcGFnZXM+PHZvbHVtZT4xODY8L3ZvbHVtZT48bnVtYmVyPjE8L251

bWJlcj48ZWRpdGlvbj4yMDEyLzA0LzIxPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD4qQWxn

b3JpdGhtczwva2V5d29yZD48a2V5d29yZD5Db21vcmJpZGl0eTwva2V5d29yZD48a2V5d29yZD5D

cml0aWNhbCBJbGxuZXNzPC9rZXl3b3JkPjxrZXl3b3JkPkRpYWJldGVzIE1lbGxpdHVzL2VwaWRl

bWlvbG9neTwva2V5d29yZD48a2V5d29yZD5IZWFydCBEaXNlYXNlcy9lcGlkZW1pb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+SGVhcnQgRmFpbHVyZS9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub2NvbXByb21pc2VkIEhvc3Q8L2tleXdv

cmQ+PGtleXdvcmQ+SW50ZW5zaXZlIENhcmUgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+UHVsbW9u

YXJ5IEFzcGVyZ2lsbG9zaXMvKmRpYWdub3Npcy9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdv

cmQ+UmVzcGlyYXRvcnkgVHJhY3QgRGlzZWFzZXMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3

b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDEyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVsIDE8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xNTM1LTQ5NzAgKEVsZWN0cm9uaWMpJiN4RDsxMDczLTQ0OVggKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyNTE3Nzg4PC9hY2Nlc3Npb24tbnVtPjx3b3Jr

LXR5cGU+TXVsdGljZW50ZXIgU3R1ZHkmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdv

diZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5u

Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMjUxNzc4ODwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE2NC9yY2NtLjIwMTExMS0xOTc4T0M8L2Vs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPk1lZXJzc2VtYW48L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+MjU2MTc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI1NjE3PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0

ZjloOTBwdzJkeHpwdGVwIj4yNTYxNzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l

PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh

dXRob3I+TWVlcnNzZW1hbiwgVy48L2F1dGhvcj48YXV0aG9yPkxhZ3JvdSwgSy48L2F1dGhvcj48

YXV0aG9yPk1hZXJ0ZW5zLCBKLjwvYXV0aG9yPjxhdXRob3I+V2lsbWVyLCBBLjwvYXV0aG9yPjxh

dXRob3I+SGVybWFucywgRy48L2F1dGhvcj48YXV0aG9yPlZhbmRlcnNjaHVlcmVuLCBTLjwvYXV0

aG9yPjxhdXRob3I+U3ByaWV0LCBJLjwvYXV0aG9yPjxhdXRob3I+VmVyYmVrZW4sIEUuPC9hdXRo

b3I+PGF1dGhvcj5WYW4gV2lqbmdhZXJkZW4sIEUuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp

YnV0b3JzPjxhdXRoLWFkZHJlc3M+TWVkaWNhbCBJbnRlbnNpdmUgQ2FyZSBVbml0LCBVbml2ZXJz

aXR5IEhvc3BpdGFsIExldXZlbiwgSGVyZXN0cmFhdCA0OSwgQi0zMDAwIExldXZlbiwgQmVsZ2l1

bS4gd291dGVyLm1lZXJzc2VtYW5AdXoua3VsZXV2ZW4uYWMuYmU8L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5HYWxhY3RvbWFubmFuIGluIGJyb25jaG9hbHZlb2xhciBsYXZhZ2UgZmx1aWQ6

IGEgdG9vbCBmb3IgZGlhZ25vc2luZyBhc3BlcmdpbGxvc2lzIGluIGludGVuc2l2ZSBjYXJlIHVu

aXQgcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW0gSiBSZXNwaXIgQ3JpdCBDYXJl

IE1lZDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QW1lcmljYW4gam91cm5hbCBvZiByZXNw

aXJhdG9yeSBhbmQgY3JpdGljYWwgY2FyZSBtZWRpY2luZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtIEogUmVzcGlyIENyaXQgQ2FyZSBNZWQ8L2Z1bGwtdGl0

bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4yNy0zNDwvcGFnZXM+PHZvbHVtZT4xNzc8L3ZvbHVtZT48

bnVtYmVyPjE8L251bWJlcj48ZWRpdGlvbj4yMDA3LzA5LzIyPC9lZGl0aW9uPjxrZXl3b3Jkcz48

a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFz

cGVyZ2lsbG9zaXMvZGlhZ25vc2lzLyptaWNyb2Jpb2xvZ3kvbW9ydGFsaXR5L3BhdGhvbG9neTwv

a2V5d29yZD48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkLyptaWNyb2Jpb2xv

Z3k8L2tleXdvcmQ+PGtleXdvcmQ+QnJvbmNob3Njb3B5PC9rZXl3b3JkPjxrZXl3b3JkPkNhdXNl

IG9mIERlYXRoPC9rZXl3b3JkPjxrZXl3b3JkPkNyb3NzIEluZmVjdGlvbi9kaWFnbm9zaXMvbWlj

cm9iaW9sb2d5L21vcnRhbGl0eS9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RGlhZ25vc2lz

LCBEaWZmZXJlbnRpYWw8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3Jk

Pkhvc3BpdGFsIE1vcnRhbGl0eTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+SW50ZW5zaXZlIENhcmUgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZy9taWNyb2Jp

b2xvZ3kvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcgRGlzZWFzZXMsIEZ1bmdhbC9k

aWFnbm9zaXMvKm1pY3JvYmlvbG9neS9tb3J0YWxpdHkvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3

b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8qYmxvb2Q8L2tleXdvcmQ+PGtleXdv

cmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXljb2xvZ2ljYWwgVHlwaW5nIFRlY2hu

aXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+T3Bwb3J0dW5pc3RpYyBJbmZlY3Rpb25zL2RpYWdub3Np

cy9taWNyb2Jpb2xvZ3kvbW9ydGFsaXR5L3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5QbmV1

bW9uaWEsIFZlbnRpbGF0b3ItQXNzb2NpYXRlZC9kaWFnbm9zaXMvKm1pY3JvYmlvbG9neS9tb3J0

YWxpdHkvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlByZWRpY3RpdmUgVmFsdWUgb2YgVGVz

dHM8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29y

ZD5TdXJ2aXZhbCBSYXRlPC9rZXl3b3JkPjxrZXl3b3JkPlRvbW9ncmFwaHksIFgtUmF5IENvbXB1

dGVkPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDg8L3llYXI+PHB1Yi1kYXRl

cz48ZGF0ZT5KYW4gMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzUtNDk3MCAo

RWxlY3Ryb25pYykmI3hEOzEwNzMtNDQ5WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+

MTc4ODUyNjQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93

d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTc4ODUyNjQ8L3VybD48L3JlbGF0ZWQtdXJscz48

L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExNjQvcmNjbS4yMDA3MDQtNjA2T0M8

L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3Jk

PjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA [59, 60]. IA has been observed in critically ill patients following other major infections, including influenza PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYXV0ZXJzPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48

UmVjTnVtPjI1NTc2PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls2MSwgNjJdPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjI1NTc2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNTU3

Njwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3

PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+V2F1dGVycywgSi48L2F1

dGhvcj48YXV0aG9yPkJhYXIsIEkuPC9hdXRob3I+PGF1dGhvcj5NZWVyc3NlbWFuLCBQLjwvYXV0

aG9yPjxhdXRob3I+TWVlcnNzZW1hbiwgVy48L2F1dGhvcj48YXV0aG9yPkRhbXMsIEsuPC9hdXRo

b3I+PGF1dGhvcj5EZSBQYWVwLCBSLjwvYXV0aG9yPjxhdXRob3I+TGFncm91LCBLLjwvYXV0aG9y

PjxhdXRob3I+V2lsbWVyLCBBLjwvYXV0aG9yPjxhdXRob3I+Sm9yZW5zLCBQLjwvYXV0aG9yPjxh

dXRob3I+SGVybWFucywgRy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt

YWRkcmVzcz5NZWRpY2FsIEludGVuc2l2ZSBDYXJlIFVuaXQsIFVuaXZlcnNpdHkgSG9zcGl0YWxz

IExldXZlbiwgTGV1dmVuLCBCZWxnaXVtLiBqb29zdC53YXV0ZXJzQG1lZC5rdWxldXZlbi5iZTwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkludmFzaXZlIHB1bG1vbmFyeSBhc3BlcmdpbGxv

c2lzIGlzIGEgZnJlcXVlbnQgY29tcGxpY2F0aW9uIG9mIGNyaXRpY2FsbHkgaWxsIEgxTjEgcGF0

aWVudHM6IGEgcmV0cm9zcGVjdGl2ZSBzdHVkeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5JbnRl

bnNpdmUgQ2FyZSBNZWQ8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkludGVuc2l2ZSBjYXJl

IG1lZGljaW5lPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SW50

ZW5zaXZlIENhcmUgTWVkPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MTc2MS04PC9w

YWdlcz48dm9sdW1lPjM4PC92b2x1bWU+PG51bWJlcj4xMTwvbnVtYmVyPjxlZGl0aW9uPjIwMTIv

MDgvMTc8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkJlbGdpdW0vZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48

a2V5d29yZD5HbHVjb2NvcnRpY29pZHMvKmFkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29y

ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5hcHByb3ByaWF0ZSBQcmVzY3JpYmluZzwva2V5

d29yZD48a2V5d29yZD4qSW5mbHVlbnphIEEgVmlydXMsIEgxTjEgU3VidHlwZTwva2V5d29yZD48

a2V5d29yZD5JbmZsdWVuemEsIEh1bWFuLypkcnVnIHRoZXJhcHkvKmVwaWRlbWlvbG9neTwva2V5

d29yZD48a2V5d29yZD5JbnRlbnNpdmUgQ2FyZSBVbml0czwva2V5d29yZD48a2V5d29yZD5JbnZh

c2l2ZSBQdWxtb25hcnkgQXNwZXJnaWxsb3Npcy8qZXBpZGVtaW9sb2d5L2V0aW9sb2d5PC9rZXl3

b3JkPjxrZXl3b3JkPkxvZ2lzdGljIE1vZGVsczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3

b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlBuZXVtb25pYSwgVmly

YWwvZHJ1ZyB0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IERpc3RyZXNzIFN5

bmRyb21lLCBBZHVsdC8qZHJ1ZyB0aGVyYXB5L3Zpcm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJl

dHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdv

cmQ+PGtleXdvcmQ+U3VwZXJpbmZlY3Rpb24vKmVwaWRlbWlvbG9neS9ldGlvbG9neTwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+Tm92

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQzMi0xMjM4IChFbGVjdHJvbmljKSYj

eEQ7MDM0Mi00NjQyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMjg5NTgyNjwvYWNj

ZXNzaW9uLW51bT48d29yay10eXBlPk11bHRpY2VudGVyIFN0dWR5PC93b3JrLXR5cGU+PHVybHM+

PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjI4

OTU4MjY8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVt

PjEwLjEwMDcvczAwMTM0LTAxMi0yNjczLTI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5n

dWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkxhdDwvQXV0

aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051bT40Njg8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjQ2ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjI1

d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDI0OTk0OTI3

Ij40Njg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl

Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxhdCwgQS48L2F1

dGhvcj48YXV0aG9yPkJoYWRlbGlhLCBOLjwvYXV0aG9yPjxhdXRob3I+TWlrbywgQi48L2F1dGhv

cj48YXV0aG9yPkZ1cnV5YSwgRS4gWS48L2F1dGhvcj48YXV0aG9yPlRob21wc29uLCBHLiBSLiwg

M3JkPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+TmV3IFlv

cmstUHJlc2J5dGVyaWFuIEhvc3BpdGFsLCBOZXcgWW9yaywgTmV3IFlvcmssIFVTQS48L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIGFmdGVyIHBhbmRl

bWljIChIMU4xKSAyMDA5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkVtZXJnIEluZmVjdCBEaXM8

L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkVtZXJnaW5nIGluZmVjdGlvdXMgZGlzZWFzZXM8

L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FbWVyZ2luZyBJbmZl

Y3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+RW1lcmcuIEluZmVjdC4gRGlzLjwv

YWJici0xPjxhYmJyLTI+RW1lcmcgSW5mZWN0IERpczwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0

LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+RW1lcmdpbmcgSW5mZWN0aW91cyBEaXNlYXNlczwvZnVs

bC10aXRsZT48YWJici0xPkVtZXJnLiBJbmZlY3QuIERpcy48L2FiYnItMT48YWJici0yPkVtZXJn

IEluZmVjdCBEaXM8L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz45NzEtMzwvcGFnZXM+

PHZvbHVtZT4xNjwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5B

ZHVsdDwva2V5d29yZD48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy9hZG1pbmlzdHJhdGlvbiAm

YW1wOyBkb3NhZ2U8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kcnVnIHRoZXJhcHkv

KmV0aW9sb2d5L3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD4qQXNwZXJnaWxsdXMgZnVtaWdh

dHVzPC9rZXl3b3JkPjxrZXl3b3JkPkZhdGFsIE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+R2x1

Y29jb3J0aWNvaWRzL2FkbWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZTwva2V5d29yZD48a2V5d29y

ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vY29tcGV0ZW5jZTwva2V5d29yZD48a2V5

d29yZD4qSW5mbHVlbnphIEEgVmlydXMsIEgxTjEgU3VidHlwZTwva2V5d29yZD48a2V5d29yZD5J

bmZsdWVuemEsIEh1bWFuLypjb21wbGljYXRpb25zL2ltbXVub2xvZ3kvdmlyb2xvZ3k8L2tleXdv

cmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NZXRoeWxwcmVkbmlzb2xvbmUvYWRt

aW5pc3RyYXRpb24gJmFtcDsgZG9zYWdlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9r

ZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IERpc3RyZXNzIFN5bmRyb21lLCBBZHVsdC9kcnVn

IHRoZXJhcHkvZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UmlzayBGYWN0b3JzPC9rZXl3b3Jk

PjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDEwPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MTA4MC02MDU5IChFbGVjdHJvbmljKSYjeEQ7MTA4MC02MDQwIChMaW5raW5nKTwvaXNi

bj48YWNjZXNzaW9uLW51bT4yMDUwNzc0ODwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11

cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMDUwNzc0ODwvdXJs

PjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj4zMDg2MjQ5PC9jdXN0b20yPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4zMjAxL2VpZDE2MDYuMTAwMTY1PC9lbGVjdHJvbmljLXJlc291

cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYXV0ZXJzPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48

UmVjTnVtPjI1NTc2PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls2MSwgNjJdPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjI1NTc2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iYTlhMHpkd3M5czkwYXZlOXhybXh0ZjloOTBwdzJkeHpwdGVwIj4yNTU3

Njwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3

PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+V2F1dGVycywgSi48L2F1

dGhvcj48YXV0aG9yPkJhYXIsIEkuPC9hdXRob3I+PGF1dGhvcj5NZWVyc3NlbWFuLCBQLjwvYXV0

aG9yPjxhdXRob3I+TWVlcnNzZW1hbiwgVy48L2F1dGhvcj48YXV0aG9yPkRhbXMsIEsuPC9hdXRo

b3I+PGF1dGhvcj5EZSBQYWVwLCBSLjwvYXV0aG9yPjxhdXRob3I+TGFncm91LCBLLjwvYXV0aG9y

PjxhdXRob3I+V2lsbWVyLCBBLjwvYXV0aG9yPjxhdXRob3I+Sm9yZW5zLCBQLjwvYXV0aG9yPjxh

dXRob3I+SGVybWFucywgRy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt

YWRkcmVzcz5NZWRpY2FsIEludGVuc2l2ZSBDYXJlIFVuaXQsIFVuaXZlcnNpdHkgSG9zcGl0YWxz

IExldXZlbiwgTGV1dmVuLCBCZWxnaXVtLiBqb29zdC53YXV0ZXJzQG1lZC5rdWxldXZlbi5iZTwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkludmFzaXZlIHB1bG1vbmFyeSBhc3BlcmdpbGxv

c2lzIGlzIGEgZnJlcXVlbnQgY29tcGxpY2F0aW9uIG9mIGNyaXRpY2FsbHkgaWxsIEgxTjEgcGF0

aWVudHM6IGEgcmV0cm9zcGVjdGl2ZSBzdHVkeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5JbnRl

bnNpdmUgQ2FyZSBNZWQ8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkludGVuc2l2ZSBjYXJl

IG1lZGljaW5lPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SW50

ZW5zaXZlIENhcmUgTWVkPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MTc2MS04PC9w

YWdlcz48dm9sdW1lPjM4PC92b2x1bWU+PG51bWJlcj4xMTwvbnVtYmVyPjxlZGl0aW9uPjIwMTIv

MDgvMTc8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkJlbGdpdW0vZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48

a2V5d29yZD5HbHVjb2NvcnRpY29pZHMvKmFkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29y

ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5hcHByb3ByaWF0ZSBQcmVzY3JpYmluZzwva2V5

d29yZD48a2V5d29yZD4qSW5mbHVlbnphIEEgVmlydXMsIEgxTjEgU3VidHlwZTwva2V5d29yZD48

a2V5d29yZD5JbmZsdWVuemEsIEh1bWFuLypkcnVnIHRoZXJhcHkvKmVwaWRlbWlvbG9neTwva2V5

d29yZD48a2V5d29yZD5JbnRlbnNpdmUgQ2FyZSBVbml0czwva2V5d29yZD48a2V5d29yZD5JbnZh

c2l2ZSBQdWxtb25hcnkgQXNwZXJnaWxsb3Npcy8qZXBpZGVtaW9sb2d5L2V0aW9sb2d5PC9rZXl3

b3JkPjxrZXl3b3JkPkxvZ2lzdGljIE1vZGVsczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3

b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlBuZXVtb25pYSwgVmly

YWwvZHJ1ZyB0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IERpc3RyZXNzIFN5

bmRyb21lLCBBZHVsdC8qZHJ1ZyB0aGVyYXB5L3Zpcm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJl

dHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdv

cmQ+PGtleXdvcmQ+U3VwZXJpbmZlY3Rpb24vKmVwaWRlbWlvbG9neS9ldGlvbG9neTwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+Tm92

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQzMi0xMjM4IChFbGVjdHJvbmljKSYj

eEQ7MDM0Mi00NjQyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMjg5NTgyNjwvYWNj

ZXNzaW9uLW51bT48d29yay10eXBlPk11bHRpY2VudGVyIFN0dWR5PC93b3JrLXR5cGU+PHVybHM+

PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjI4

OTU4MjY8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVt

PjEwLjEwMDcvczAwMTM0LTAxMi0yNjczLTI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5n

dWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkxhdDwvQXV0

aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051bT40Njg8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjQ2ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjI1

d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDI0OTk0OTI3

Ij40Njg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl

Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxhdCwgQS48L2F1

dGhvcj48YXV0aG9yPkJoYWRlbGlhLCBOLjwvYXV0aG9yPjxhdXRob3I+TWlrbywgQi48L2F1dGhv

cj48YXV0aG9yPkZ1cnV5YSwgRS4gWS48L2F1dGhvcj48YXV0aG9yPlRob21wc29uLCBHLiBSLiwg

M3JkPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+TmV3IFlv

cmstUHJlc2J5dGVyaWFuIEhvc3BpdGFsLCBOZXcgWW9yaywgTmV3IFlvcmssIFVTQS48L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIGFmdGVyIHBhbmRl

bWljIChIMU4xKSAyMDA5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkVtZXJnIEluZmVjdCBEaXM8

L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkVtZXJnaW5nIGluZmVjdGlvdXMgZGlzZWFzZXM8

L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FbWVyZ2luZyBJbmZl

Y3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+RW1lcmcuIEluZmVjdC4gRGlzLjwv

YWJici0xPjxhYmJyLTI+RW1lcmcgSW5mZWN0IERpczwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0

LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+RW1lcmdpbmcgSW5mZWN0aW91cyBEaXNlYXNlczwvZnVs

bC10aXRsZT48YWJici0xPkVtZXJnLiBJbmZlY3QuIERpcy48L2FiYnItMT48YWJici0yPkVtZXJn

IEluZmVjdCBEaXM8L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz45NzEtMzwvcGFnZXM+

PHZvbHVtZT4xNjwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5B

ZHVsdDwva2V5d29yZD48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy9hZG1pbmlzdHJhdGlvbiAm

YW1wOyBkb3NhZ2U8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kcnVnIHRoZXJhcHkv

KmV0aW9sb2d5L3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD4qQXNwZXJnaWxsdXMgZnVtaWdh

dHVzPC9rZXl3b3JkPjxrZXl3b3JkPkZhdGFsIE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+R2x1

Y29jb3J0aWNvaWRzL2FkbWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZTwva2V5d29yZD48a2V5d29y

ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vY29tcGV0ZW5jZTwva2V5d29yZD48a2V5

d29yZD4qSW5mbHVlbnphIEEgVmlydXMsIEgxTjEgU3VidHlwZTwva2V5d29yZD48a2V5d29yZD5J

bmZsdWVuemEsIEh1bWFuLypjb21wbGljYXRpb25zL2ltbXVub2xvZ3kvdmlyb2xvZ3k8L2tleXdv

cmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NZXRoeWxwcmVkbmlzb2xvbmUvYWRt

aW5pc3RyYXRpb24gJmFtcDsgZG9zYWdlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9r

ZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IERpc3RyZXNzIFN5bmRyb21lLCBBZHVsdC9kcnVn

IHRoZXJhcHkvZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UmlzayBGYWN0b3JzPC9rZXl3b3Jk

PjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDEwPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MTA4MC02MDU5IChFbGVjdHJvbmljKSYjeEQ7MTA4MC02MDQwIChMaW5raW5nKTwvaXNi

bj48YWNjZXNzaW9uLW51bT4yMDUwNzc0ODwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11

cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMDUwNzc0ODwvdXJs

PjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj4zMDg2MjQ5PC9jdXN0b20yPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4zMjAxL2VpZDE2MDYuMTAwMTY1PC9lbGVjdHJvbmljLXJlc291

cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [61, 62]. Since critically ill patients are heterogeneous with regard to the underlying disease, comorbidities, and level of immunocompromised PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWRkbGV5PC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48

UmVjTnVtPjUwNDwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNjNdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjUwNDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIx

NDMyMzIyMzc2Ij41MDQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJh

ZGRsZXksIEouIFcuPC9hdXRob3I+PGF1dGhvcj5TdGVwaGVucywgSi4gTS48L2F1dGhvcj48YXV0

aG9yPkppLCBYLjwvYXV0aG9yPjxhdXRob3I+R2FvLCBYLjwvYXV0aG9yPjxhdXRob3I+U2NobGFt

bSwgSC4gVC48L2F1dGhvcj48YXV0aG9yPlRhcmFsbG8sIE0uPC9hdXRob3I+PC9hdXRob3JzPjwv

Y29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgRGl2aXNp

b24gb2YgSW5mZWN0aW91cyBEaXNlYXNlcywgVW5pdmVyc2l0eSBvZiBBbGFiYW1hIGF0IEJpcm1p

bmdoYW0sIDE5MDAgVW5pdmVyc2l0eSBCb3VsZXZhcmQsIDIyOSBUaW5zbGV5IEhhcnJpc29uIFRv

d2VyLCBCaXJtaW5naGFtLCBBTCAzNTI5NC0wMDA2LCBVU0EuIGpiYWRkbGV5QHVhYi5lZHU8L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Bc3BlcmdpbGxvc2lzIGluIEludGVuc2l2ZSBDYXJl

IFVuaXQgKElDVSkgcGF0aWVudHM6IGVwaWRlbWlvbG9neSBhbmQgZWNvbm9taWMgb3V0Y29tZXM8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qk1DIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48

YWx0LXRpdGxlPkJNQyBpbmZlY3Rpb3VzIGRpc2Vhc2VzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+Qk1DIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+

PGFiYnItMT5CTUMgSW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5CTUMgSW5mZWN0IERpczwv

YWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Qk1DIEluZmVj

dGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5CTUMgSW5mZWN0LiBEaXMuPC9hYmJy

LTE+PGFiYnItMj5CTUMgSW5mZWN0IERpczwvYWJici0yPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2Vz

PjI5PC9wYWdlcz48dm9sdW1lPjEzPC92b2x1bWU+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQ8L2tl

eXdvcmQ+PGtleXdvcmQ+QW50aWZ1bmdhbCBBZ2VudHMvZWNvbm9taWNzL3RoZXJhcGV1dGljIHVz

ZTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2RydWcgdGhlcmFweS8qZWNvbm9taWNz

LyplcGlkZW1pb2xvZ3kvZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPkhvc3BpdGFsIENvc3RzPC9rZXl3b3JkPjxrZXl3b3JkPkhvc3BpdGFsIE1vcnRh

bGl0eTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkludGVuc2l2

ZSBDYXJlIFVuaXRzL2Vjb25vbWljczwva2V5d29yZD48a2V5d29yZD5MZW5ndGggb2YgU3RheS9l

Y29ub21pY3M8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUg

QWdlZDwva2V5d29yZD48a2V5d29yZD5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PC9r

ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMzwveWVhcj48L2RhdGVzPjxpc2JuPjE0NzEtMjMzNCAo

RWxlY3Ryb25pYykmI3hEOzE0NzEtMjMzNCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+

MjMzNDMzNjY8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93

d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjMzNDMzNjY8L3VybD48L3JlbGF0ZWQtdXJscz48

L3VybHM+PGN1c3RvbTI+MzU2MjI1NDwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTE4Ni8xNDcxLTIzMzQtMTMtMjk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3Jk

PjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWRkbGV5PC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48

UmVjTnVtPjUwNDwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNjNdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjUwNDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIx

NDMyMzIyMzc2Ij41MDQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJh

ZGRsZXksIEouIFcuPC9hdXRob3I+PGF1dGhvcj5TdGVwaGVucywgSi4gTS48L2F1dGhvcj48YXV0

aG9yPkppLCBYLjwvYXV0aG9yPjxhdXRob3I+R2FvLCBYLjwvYXV0aG9yPjxhdXRob3I+U2NobGFt

bSwgSC4gVC48L2F1dGhvcj48YXV0aG9yPlRhcmFsbG8sIE0uPC9hdXRob3I+PC9hdXRob3JzPjwv

Y29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgRGl2aXNp

b24gb2YgSW5mZWN0aW91cyBEaXNlYXNlcywgVW5pdmVyc2l0eSBvZiBBbGFiYW1hIGF0IEJpcm1p

bmdoYW0sIDE5MDAgVW5pdmVyc2l0eSBCb3VsZXZhcmQsIDIyOSBUaW5zbGV5IEhhcnJpc29uIFRv

d2VyLCBCaXJtaW5naGFtLCBBTCAzNTI5NC0wMDA2LCBVU0EuIGpiYWRkbGV5QHVhYi5lZHU8L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Bc3BlcmdpbGxvc2lzIGluIEludGVuc2l2ZSBDYXJl

IFVuaXQgKElDVSkgcGF0aWVudHM6IGVwaWRlbWlvbG9neSBhbmQgZWNvbm9taWMgb3V0Y29tZXM8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qk1DIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48

YWx0LXRpdGxlPkJNQyBpbmZlY3Rpb3VzIGRpc2Vhc2VzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+Qk1DIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+

PGFiYnItMT5CTUMgSW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5CTUMgSW5mZWN0IERpczwv

YWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Qk1DIEluZmVj

dGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5CTUMgSW5mZWN0LiBEaXMuPC9hYmJy

LTE+PGFiYnItMj5CTUMgSW5mZWN0IERpczwvYWJici0yPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2Vz

PjI5PC9wYWdlcz48dm9sdW1lPjEzPC92b2x1bWU+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQ8L2tl

eXdvcmQ+PGtleXdvcmQ+QW50aWZ1bmdhbCBBZ2VudHMvZWNvbm9taWNzL3RoZXJhcGV1dGljIHVz

ZTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2RydWcgdGhlcmFweS8qZWNvbm9taWNz

LyplcGlkZW1pb2xvZ3kvZXRpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPkhvc3BpdGFsIENvc3RzPC9rZXl3b3JkPjxrZXl3b3JkPkhvc3BpdGFsIE1vcnRh

bGl0eTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkludGVuc2l2

ZSBDYXJlIFVuaXRzL2Vjb25vbWljczwva2V5d29yZD48a2V5d29yZD5MZW5ndGggb2YgU3RheS9l

Y29ub21pY3M8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUg

QWdlZDwva2V5d29yZD48a2V5d29yZD5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PC9r

ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMzwveWVhcj48L2RhdGVzPjxpc2JuPjE0NzEtMjMzNCAo

RWxlY3Ryb25pYykmI3hEOzE0NzEtMjMzNCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+

MjMzNDMzNjY8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93

d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjMzNDMzNjY8L3VybD48L3JlbGF0ZWQtdXJscz48

L3VybHM+PGN1c3RvbTI+MzU2MjI1NDwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTE4Ni8xNDcxLTIzMzQtMTMtMjk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3Jk

PjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA [63], it is difficult to delineate the specific role of non-classic risk factors (e.g., multi-organ organ failure, prolonged mechanical ventilation, bacterial and viral infections including influenza) in driving the risk for IA.DIAGNOSIS OF ASPERGILLOSIS II. How can a diagnosis of IA be established?How should Aspergillus be identified and how does this influence management? Recommendation6.Until molecular tools are more widely used in clinical laboratories, we recommend that tissue and fluid specimens be submitted in adequate quantities for simultaneous histopathologic/cytologic and culture examination. In the case of isolates with atypical growth or concerns for resistance, species identification by molecular methods should be employed. (Strong Recommendation; High Quality Evidence).Evidence summaryThe EORTC/MSG revised criteria for defining invasive fungal infections, including IA, require a microbiologic and/or histopathologic diagnosis to define proven infection PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EZSBQYXV3PC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48

UmVjTnVtPjUzOTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNjRdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjUzOTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIx

NDM2MjA3NTM5Ij41Mzk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkRl

IFBhdXcsIEIuPC9hdXRob3I+PGF1dGhvcj5XYWxzaCwgVC4gSi48L2F1dGhvcj48YXV0aG9yPkRv

bm5lbGx5LCBKLiBQLjwvYXV0aG9yPjxhdXRob3I+U3RldmVucywgRC4gQS48L2F1dGhvcj48YXV0

aG9yPkVkd2FyZHMsIEouIEUuPC9hdXRob3I+PGF1dGhvcj5DYWxhbmRyYSwgVC48L2F1dGhvcj48

YXV0aG9yPlBhcHBhcywgUC4gRy48L2F1dGhvcj48YXV0aG9yPk1hZXJ0ZW5zLCBKLjwvYXV0aG9y

PjxhdXRob3I+TG9ydGhvbGFyeSwgTy48L2F1dGhvcj48YXV0aG9yPkthdWZmbWFuLCBDLiBBLjwv

YXV0aG9yPjxhdXRob3I+RGVubmluZywgRC4gVy48L2F1dGhvcj48YXV0aG9yPlBhdHRlcnNvbiwg

VC4gRi48L2F1dGhvcj48YXV0aG9yPk1hc2NobWV5ZXIsIEcuPC9hdXRob3I+PGF1dGhvcj5CaWxs

ZSwgSi48L2F1dGhvcj48YXV0aG9yPkRpc211a2VzLCBXLiBFLjwvYXV0aG9yPjxhdXRob3I+SGVy

YnJlY2h0LCBSLjwvYXV0aG9yPjxhdXRob3I+SG9wZSwgVy4gVy48L2F1dGhvcj48YXV0aG9yPktp

YmJsZXIsIEMuIEMuPC9hdXRob3I+PGF1dGhvcj5LdWxsYmVyZywgQi4gSi48L2F1dGhvcj48YXV0

aG9yPk1hcnIsIEsuIEEuPC9hdXRob3I+PGF1dGhvcj5NdW5veiwgUC48L2F1dGhvcj48YXV0aG9y

Pk9kZHMsIEYuIEMuPC9hdXRob3I+PGF1dGhvcj5QZXJmZWN0LCBKLiBSLjwvYXV0aG9yPjxhdXRo

b3I+UmVzdHJlcG8sIEEuPC9hdXRob3I+PGF1dGhvcj5SdWhua2UsIE0uPC9hdXRob3I+PGF1dGhv

cj5TZWdhbCwgQi4gSC48L2F1dGhvcj48YXV0aG9yPlNvYmVsLCBKLiBELjwvYXV0aG9yPjxhdXRo

b3I+U29ycmVsbCwgVC4gQy48L2F1dGhvcj48YXV0aG9yPlZpc2NvbGksIEMuPC9hdXRob3I+PGF1

dGhvcj5XaW5nYXJkLCBKLiBSLjwvYXV0aG9yPjxhdXRob3I+WmFvdXRpcywgVC48L2F1dGhvcj48

YXV0aG9yPkJlbm5ldHQsIEouIEUuPC9hdXRob3I+PGF1dGhvcj5FdXJvcGVhbiBPcmdhbml6YXRp

b24gZm9yLCBSZXNlYXJjaDwvYXV0aG9yPjxhdXRob3I+VHJlYXRtZW50IG9mIENhbmNlci9JbnZh

c2l2ZSBGdW5nYWwgSW5mZWN0aW9ucyBDb29wZXJhdGl2ZSwgR3JvdXA8L2F1dGhvcj48YXV0aG9y

Pk5hdGlvbmFsIEluc3RpdHV0ZSBvZiwgQWxsZXJneTwvYXV0aG9yPjxhdXRob3I+SW5mZWN0aW91

cyBEaXNlYXNlcyBNeWNvc2VzIFN0dWR5IEdyb3VwIENvbnNlbnN1cywgR3JvdXA8L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIEJsb29k

IFRyYW5zZnVzaW9uIFNlcnZpY2UgYW5kIFRyYW5zcGxhbnQgSW1tdW5vbG9neSwgUmFkYm91ZCBV

bml2ZXJzaXR5IE5pam1lZ2VuIE1lZGljYWwgQ2VudHJlLCBOaWptZWdlbiwgVGhlIE5ldGhlcmxh

bmRzLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlJldmlzZWQgZGVmaW5pdGlvbnMgb2Yg

aW52YXNpdmUgZnVuZ2FsIGRpc2Vhc2UgZnJvbSB0aGUgRXVyb3BlYW4gT3JnYW5pemF0aW9uIGZv

ciBSZXNlYXJjaCBhbmQgVHJlYXRtZW50IG9mIENhbmNlci9JbnZhc2l2ZSBGdW5nYWwgSW5mZWN0

aW9ucyBDb29wZXJhdGl2ZSBHcm91cCBhbmQgdGhlIE5hdGlvbmFsIEluc3RpdHV0ZSBvZiBBbGxl

cmd5IGFuZCBJbmZlY3Rpb3VzIERpc2Vhc2VzIE15Y29zZXMgU3R1ZHkgR3JvdXAgKEVPUlRDL01T

RykgQ29uc2Vuc3VzIEdyb3VwPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW4gSW5mZWN0IERp

czwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwgaW5mZWN0aW91cyBkaXNlYXNl

cyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNv

Y2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRp

dGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5DbGlu

LiBJbmZlY3QuIERpcy48L2FiYnItMT48YWJici0yPkNsaW4gSW5mZWN0IERpczwvYWJici0yPjwv

cGVyaW9kaWNhbD48cGFnZXM+MTgxMy0yMTwvcGFnZXM+PHZvbHVtZT40Njwvdm9sdW1lPjxudW1i

ZXI+MTI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3Jk

Pk15Y29zZXMvKmNsYXNzaWZpY2F0aW9uLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+KlRl

cm1pbm9sb2d5IGFzIFRvcGljPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDg8

L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdW4gMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48

aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU4LTQ4MzggKExpbmtpbmcpPC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjE4NDYyMTAyPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzE4NDYyMTAyPC91cmw+

PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPjI2NzEyMjc8L2N1c3RvbTI+PGVsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjEwLjEwODYvNTg4NjYwPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48

L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EZSBQYXV3PC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48

UmVjTnVtPjUzOTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNjRdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjUzOTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIx

NDM2MjA3NTM5Ij41Mzk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkRl

IFBhdXcsIEIuPC9hdXRob3I+PGF1dGhvcj5XYWxzaCwgVC4gSi48L2F1dGhvcj48YXV0aG9yPkRv

bm5lbGx5LCBKLiBQLjwvYXV0aG9yPjxhdXRob3I+U3RldmVucywgRC4gQS48L2F1dGhvcj48YXV0

aG9yPkVkd2FyZHMsIEouIEUuPC9hdXRob3I+PGF1dGhvcj5DYWxhbmRyYSwgVC48L2F1dGhvcj48

YXV0aG9yPlBhcHBhcywgUC4gRy48L2F1dGhvcj48YXV0aG9yPk1hZXJ0ZW5zLCBKLjwvYXV0aG9y

PjxhdXRob3I+TG9ydGhvbGFyeSwgTy48L2F1dGhvcj48YXV0aG9yPkthdWZmbWFuLCBDLiBBLjwv

YXV0aG9yPjxhdXRob3I+RGVubmluZywgRC4gVy48L2F1dGhvcj48YXV0aG9yPlBhdHRlcnNvbiwg

VC4gRi48L2F1dGhvcj48YXV0aG9yPk1hc2NobWV5ZXIsIEcuPC9hdXRob3I+PGF1dGhvcj5CaWxs

ZSwgSi48L2F1dGhvcj48YXV0aG9yPkRpc211a2VzLCBXLiBFLjwvYXV0aG9yPjxhdXRob3I+SGVy

YnJlY2h0LCBSLjwvYXV0aG9yPjxhdXRob3I+SG9wZSwgVy4gVy48L2F1dGhvcj48YXV0aG9yPktp

YmJsZXIsIEMuIEMuPC9hdXRob3I+PGF1dGhvcj5LdWxsYmVyZywgQi4gSi48L2F1dGhvcj48YXV0

aG9yPk1hcnIsIEsuIEEuPC9hdXRob3I+PGF1dGhvcj5NdW5veiwgUC48L2F1dGhvcj48YXV0aG9y

Pk9kZHMsIEYuIEMuPC9hdXRob3I+PGF1dGhvcj5QZXJmZWN0LCBKLiBSLjwvYXV0aG9yPjxhdXRo

b3I+UmVzdHJlcG8sIEEuPC9hdXRob3I+PGF1dGhvcj5SdWhua2UsIE0uPC9hdXRob3I+PGF1dGhv

cj5TZWdhbCwgQi4gSC48L2F1dGhvcj48YXV0aG9yPlNvYmVsLCBKLiBELjwvYXV0aG9yPjxhdXRo

b3I+U29ycmVsbCwgVC4gQy48L2F1dGhvcj48YXV0aG9yPlZpc2NvbGksIEMuPC9hdXRob3I+PGF1

dGhvcj5XaW5nYXJkLCBKLiBSLjwvYXV0aG9yPjxhdXRob3I+WmFvdXRpcywgVC48L2F1dGhvcj48

YXV0aG9yPkJlbm5ldHQsIEouIEUuPC9hdXRob3I+PGF1dGhvcj5FdXJvcGVhbiBPcmdhbml6YXRp

b24gZm9yLCBSZXNlYXJjaDwvYXV0aG9yPjxhdXRob3I+VHJlYXRtZW50IG9mIENhbmNlci9JbnZh

c2l2ZSBGdW5nYWwgSW5mZWN0aW9ucyBDb29wZXJhdGl2ZSwgR3JvdXA8L2F1dGhvcj48YXV0aG9y

Pk5hdGlvbmFsIEluc3RpdHV0ZSBvZiwgQWxsZXJneTwvYXV0aG9yPjxhdXRob3I+SW5mZWN0aW91

cyBEaXNlYXNlcyBNeWNvc2VzIFN0dWR5IEdyb3VwIENvbnNlbnN1cywgR3JvdXA8L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIEJsb29k

IFRyYW5zZnVzaW9uIFNlcnZpY2UgYW5kIFRyYW5zcGxhbnQgSW1tdW5vbG9neSwgUmFkYm91ZCBV

bml2ZXJzaXR5IE5pam1lZ2VuIE1lZGljYWwgQ2VudHJlLCBOaWptZWdlbiwgVGhlIE5ldGhlcmxh

bmRzLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlJldmlzZWQgZGVmaW5pdGlvbnMgb2Yg

aW52YXNpdmUgZnVuZ2FsIGRpc2Vhc2UgZnJvbSB0aGUgRXVyb3BlYW4gT3JnYW5pemF0aW9uIGZv

ciBSZXNlYXJjaCBhbmQgVHJlYXRtZW50IG9mIENhbmNlci9JbnZhc2l2ZSBGdW5nYWwgSW5mZWN0

aW9ucyBDb29wZXJhdGl2ZSBHcm91cCBhbmQgdGhlIE5hdGlvbmFsIEluc3RpdHV0ZSBvZiBBbGxl

cmd5IGFuZCBJbmZlY3Rpb3VzIERpc2Vhc2VzIE15Y29zZXMgU3R1ZHkgR3JvdXAgKEVPUlRDL01T

RykgQ29uc2Vuc3VzIEdyb3VwPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW4gSW5mZWN0IERp

czwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwgaW5mZWN0aW91cyBkaXNlYXNl

cyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNv

Y2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRp

dGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5DbGlu

LiBJbmZlY3QuIERpcy48L2FiYnItMT48YWJici0yPkNsaW4gSW5mZWN0IERpczwvYWJici0yPjwv

cGVyaW9kaWNhbD48cGFnZXM+MTgxMy0yMTwvcGFnZXM+PHZvbHVtZT40Njwvdm9sdW1lPjxudW1i

ZXI+MTI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3Jk

Pk15Y29zZXMvKmNsYXNzaWZpY2F0aW9uLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+KlRl

cm1pbm9sb2d5IGFzIFRvcGljPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDg8

L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdW4gMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48

aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU4LTQ4MzggKExpbmtpbmcpPC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjE4NDYyMTAyPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzE4NDYyMTAyPC91cmw+

PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPjI2NzEyMjc8L2N1c3RvbTI+PGVsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjEwLjEwODYvNTg4NjYwPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48

L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [64]. However, specimen acquisition is challenging in many patients. Histopathologic evidence of fungi is crucial to determine the significance of Aspergillus growing in culture; yet diagnostic accuracy of histopathology is sub-optimal PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW5nb2k8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

ZWNOdW0+Nzk4PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls2NS02N108L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+Nzk4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9

IjE0NTQzNjI4NTMiPjc5ODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

U2FuZ29pLCBBLiBSLjwvYXV0aG9yPjxhdXRob3I+Um9nZXJzLCBXLiBNLjwvYXV0aG9yPjxhdXRo

b3I+TG9uZ2FjcmUsIFQuIEEuPC9hdXRob3I+PGF1dGhvcj5Nb250b3lhLCBKLiBHLjwvYXV0aG9y

PjxhdXRob3I+QmFyb24sIEUuIEouPC9hdXRob3I+PGF1dGhvcj5CYW5hZWksIE4uPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQYXRo

b2xvZ3ksIFN0YW5mb3JkIFVuaXZlcnNpdHksIFN0YW5mb3JkLCBDQSA5NDMwNSwgVVNBLjwvYXV0

aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNoYWxsZW5nZXMgYW5kIHBpdGZhbGxzIG9mIG1vcnBo

b2xvZ2ljIGlkZW50aWZpY2F0aW9uIG9mIGZ1bmdhbCBpbmZlY3Rpb25zIGluIGhpc3RvbG9naWMg

YW5kIGN5dG9sb2dpYyBzcGVjaW1lbnM6IGEgdGVuLXllYXIgcmV0cm9zcGVjdGl2ZSByZXZpZXcg

YXQgYSBzaW5nbGUgaW5zdGl0dXRpb248L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW0gSiBDbGlu

IFBhdGhvbDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgUGF0aG9sb2d5PC9mdWxsLXRpdGxlPjxhYmJy

LTE+QW0uIEouIENsaW4uIFBhdGhvbC48L2FiYnItMT48YWJici0yPkFtIEogQ2xpbiBQYXRob2w8

L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjM2NC03NTwvcGFnZXM+PHZvbHVtZT4xMzE8L3Zv

bHVtZT48bnVtYmVyPjM8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+

PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29y

ZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3

b3JkPjxrZXl3b3JkPipDeXRvbG9naWNhbCBUZWNobmlxdWVzPC9rZXl3b3JkPjxrZXl3b3JkPkRp

YWdub3N0aWMgRXJyb3JzLypzdGF0aXN0aWNzICZhbXA7IG51bWVyaWNhbCBkYXRhPC9rZXl3b3Jk

PjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5GdW5naS8qdWx0cmFzdHJ1Y3R1cmU8

L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluZmFudDwva2V5d29y

ZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxr

ZXl3b3JkPk15Y29zZXMvKmRpYWdub3Npcy8qbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3Jk

PlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDA5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MTk0My03NzIyIChFbGVjdHJvbmljKSYjeEQ7MDAwMi05MTczIChMaW5raW5nKTwvaXNi

bj48YWNjZXNzaW9uLW51bT4xOTIyODY0MjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11

cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xOTIyODY0MjwvdXJs

PjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTMwOS9B

SkNQOTlPT09aU05JU0NaPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+

PENpdGU+PEF1dGhvcj5TaGFoPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVjTnVtPjc5OTwv

UmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+Nzk5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+

PGtleSBhcHA9IkVOIiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRy

IiB0aW1lc3RhbXA9IjE0NTQzNjg1OTkiPjc5OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+U2hhaCwgQS4gQS48L2F1dGhvcj48YXV0aG9yPkhhemVuLCBLLiBDLjwvYXV0

aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcHQgb2YgUGF0aG9s

b2d5LCBVbml2ZXJzaXR5IG9mIFZpcmdpbmlhIEhlYWx0aCBTeXN0ZW0sIENoYXJsb3R0ZXN2aWxs

ZSwgVkEgMjI5MDgsIFVTQS4gYWFzN3RAdmlyZ2luaWEuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RGlhZ25vc3RpYyBhY2N1cmFjeSBvZiBoaXN0b3BhdGhvbG9naWMgYW5kIGN5dG9w

YXRob2xvZ2ljIGV4YW1pbmF0aW9uIG9mIEFzcGVyZ2lsbHVzIHNwZWNpZXM8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+QW0gSiBDbGluIFBhdGhvbDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgUGF0aG9s

b2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+QW0uIEouIENsaW4uIFBhdGhvbC48L2FiYnItMT48YWJi

ci0yPkFtIEogQ2xpbiBQYXRob2w8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjU1LTYxPC9w

YWdlcz48dm9sdW1lPjEzOTwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5

d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVy

Z2lsbG9zaXMvKmRpYWdub3Npcy9zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVz

L2NsYXNzaWZpY2F0aW9uLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3JkPjxr

ZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkN1bHR1cmUgVGVjaG5pcXVlczwva2V5d29y

ZD48a2V5d29yZD5ETkEsIEZ1bmdhbC9hbmFseXNpczwva2V5d29yZD48a2V5d29yZD5EaWFnbm9z

dGljIEVycm9ycy8qc3RhdGlzdGljcyAmYW1wOyBudW1lcmljYWwgZGF0YTwva2V5d29yZD48a2V5

d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1h

bGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXljb2xv

Z2ljYWwgVHlwaW5nIFRlY2huaXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+UmVwcm9kdWNpYmlsaXR5

IG9mIFJlc3VsdHM8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3

b3JkPjxrZXl3b3JkPlNlcXVlbmNlIEFuYWx5c2lzLCBETkE8L2tleXdvcmQ+PGtleXdvcmQ+WW91

bmcgQWR1bHQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMzwveWVhcj48cHVi

LWRhdGVzPjxkYXRlPkphbjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE5NDMtNzcy

MiAoRWxlY3Ryb25pYykmI3hEOzAwMDItOTE3MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+MjMyNzA4OTk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6

Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjMyNzA4OTk8L3VybD48L3JlbGF0ZWQtdXJs

cz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEzMDkvQUpDUE84VlRTSzNIUk5V

VDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+

VGFycmFuZDwvQXV0aG9yPjxZZWFyPjIwMDM8L1llYXI+PFJlY051bT44MDA8L1JlY051bT48cmVj

b3JkPjxyZWMtbnVtYmVyPjgwMDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1w

PSIxNDU0MzY4NjcyIj44MDA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PlRhcnJhbmQsIEouIEouPC9hdXRob3I+PGF1dGhvcj5MaWNodGVyZmVsZCwgTS48L2F1dGhvcj48

YXV0aG9yPldhcnJhaWNoLCBJLjwvYXV0aG9yPjxhdXRob3I+THVuYSwgTS48L2F1dGhvcj48YXV0

aG9yPkhhbiwgWC4gWS48L2F1dGhvcj48YXV0aG9yPk1heSwgRy4gUy48L2F1dGhvcj48YXV0aG9y

PktvbnRveWlhbm5pcywgRC4gUC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1

dGgtYWRkcmVzcz5EaXZpc2lvbiBvZiBQYXRob2xvZ3kgYW5kIExhYm9yYXRvcnkgTWVkaWNpbmUs

IEJveCA4NCwgVW5pdmVyc2l0eSBvZiBUZXhhcyBNLkQuIEFuZGVyc29uIENhbmNlciBDZW50ZXIs

IDE1MTUgSG9sY29tYmUgQmx2ZCwgSG91c3RvbiwgVFggNzcwMzAsIFVTQS48L2F1dGgtYWRkcmVz

cz48dGl0bGVzPjx0aXRsZT5EaWFnbm9zaXMgb2YgaW52YXNpdmUgc2VwdGF0ZSBtb2xkIGluZmVj

dGlvbnMuIEEgY29ycmVsYXRpb24gb2YgbWljcm9iaW9sb2dpY2FsIGN1bHR1cmUgYW5kIGhpc3Rv

bG9naWMgb3IgY3l0b2xvZ2ljIGV4YW1pbmF0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFt

IEogQ2xpbiBQYXRob2w8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIFBhdGhvbG9neTwvZnVsbC10aXRs

ZT48YWJici0xPkFtLiBKLiBDbGluLiBQYXRob2wuPC9hYmJyLTE+PGFiYnItMj5BbSBKIENsaW4g

UGF0aG9sPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz44NTQtODwvcGFnZXM+PHZvbHVtZT4x

MTk8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QXNwZXJnaWxs

b3Npcy9kaWFnbm9zaXMvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVz

L2dyb3d0aCAmYW1wOyBkZXZlbG9wbWVudC9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9r

ZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzIGZsYXZ1cy9ncm93dGggJmFtcDsgZGV2ZWxvcG1l

bnQvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5Bc3Blcmdp

bGx1cyBmdW1pZ2F0dXMvZ3Jvd3RoICZhbXA7IGRldmVsb3BtZW50L2lzb2xhdGlvbiAmYW1wOyBw

dXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMgbmlnZXIvZ3Jvd3RoICZh

bXA7IGRldmVsb3BtZW50L2lzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtl

eXdvcmQ+QXV0b3BzeTwva2V5d29yZD48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZs

dWlkL21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5GdXNhcml1bS9ncm93dGggJmFtcDsg

ZGV2ZWxvcG1lbnQvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29y

ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBEaXNlYXNlcywgRnVuZ2FsLypkaWFnbm9z

aXMvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPk15Y29zZXMvKmRpYWdub3Npcy9taWNy

b2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3Jk

PjxrZXl3b3JkPlNjZWRvc3Bvcml1bS9ncm93dGggJmFtcDsgZGV2ZWxvcG1lbnQvaXNvbGF0aW9u

ICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAz

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlz

Ym4+MDAwMi05MTczIChQcmludCkmI3hEOzAwMDItOTE3MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MTI4MTc0MzM8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTI4MTc0MzM8L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEzMDkvRVhCVi1ZQVVQ

LUVOQk0tMjg1WTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k

Tm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW5nb2k8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

ZWNOdW0+Nzk4PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls2NS02N108L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+Nzk4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9

IjE0NTQzNjI4NTMiPjc5ODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

U2FuZ29pLCBBLiBSLjwvYXV0aG9yPjxhdXRob3I+Um9nZXJzLCBXLiBNLjwvYXV0aG9yPjxhdXRo

b3I+TG9uZ2FjcmUsIFQuIEEuPC9hdXRob3I+PGF1dGhvcj5Nb250b3lhLCBKLiBHLjwvYXV0aG9y

PjxhdXRob3I+QmFyb24sIEUuIEouPC9hdXRob3I+PGF1dGhvcj5CYW5hZWksIE4uPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQYXRo

b2xvZ3ksIFN0YW5mb3JkIFVuaXZlcnNpdHksIFN0YW5mb3JkLCBDQSA5NDMwNSwgVVNBLjwvYXV0

aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNoYWxsZW5nZXMgYW5kIHBpdGZhbGxzIG9mIG1vcnBo

b2xvZ2ljIGlkZW50aWZpY2F0aW9uIG9mIGZ1bmdhbCBpbmZlY3Rpb25zIGluIGhpc3RvbG9naWMg

YW5kIGN5dG9sb2dpYyBzcGVjaW1lbnM6IGEgdGVuLXllYXIgcmV0cm9zcGVjdGl2ZSByZXZpZXcg

YXQgYSBzaW5nbGUgaW5zdGl0dXRpb248L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW0gSiBDbGlu

IFBhdGhvbDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgUGF0aG9sb2d5PC9mdWxsLXRpdGxlPjxhYmJy

LTE+QW0uIEouIENsaW4uIFBhdGhvbC48L2FiYnItMT48YWJici0yPkFtIEogQ2xpbiBQYXRob2w8

L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjM2NC03NTwvcGFnZXM+PHZvbHVtZT4xMzE8L3Zv

bHVtZT48bnVtYmVyPjM8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+

PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29y

ZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3

b3JkPjxrZXl3b3JkPipDeXRvbG9naWNhbCBUZWNobmlxdWVzPC9rZXl3b3JkPjxrZXl3b3JkPkRp

YWdub3N0aWMgRXJyb3JzLypzdGF0aXN0aWNzICZhbXA7IG51bWVyaWNhbCBkYXRhPC9rZXl3b3Jk

PjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5GdW5naS8qdWx0cmFzdHJ1Y3R1cmU8

L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluZmFudDwva2V5d29y

ZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxr

ZXl3b3JkPk15Y29zZXMvKmRpYWdub3Npcy8qbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3Jk

PlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDA5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MTk0My03NzIyIChFbGVjdHJvbmljKSYjeEQ7MDAwMi05MTczIChMaW5raW5nKTwvaXNi

bj48YWNjZXNzaW9uLW51bT4xOTIyODY0MjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11

cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xOTIyODY0MjwvdXJs

PjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTMwOS9B

SkNQOTlPT09aU05JU0NaPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+

PENpdGU+PEF1dGhvcj5TaGFoPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVjTnVtPjc5OTwv

UmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+Nzk5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+

PGtleSBhcHA9IkVOIiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRy

IiB0aW1lc3RhbXA9IjE0NTQzNjg1OTkiPjc5OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+U2hhaCwgQS4gQS48L2F1dGhvcj48YXV0aG9yPkhhemVuLCBLLiBDLjwvYXV0

aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcHQgb2YgUGF0aG9s

b2d5LCBVbml2ZXJzaXR5IG9mIFZpcmdpbmlhIEhlYWx0aCBTeXN0ZW0sIENoYXJsb3R0ZXN2aWxs

ZSwgVkEgMjI5MDgsIFVTQS4gYWFzN3RAdmlyZ2luaWEuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RGlhZ25vc3RpYyBhY2N1cmFjeSBvZiBoaXN0b3BhdGhvbG9naWMgYW5kIGN5dG9w

YXRob2xvZ2ljIGV4YW1pbmF0aW9uIG9mIEFzcGVyZ2lsbHVzIHNwZWNpZXM8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+QW0gSiBDbGluIFBhdGhvbDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgUGF0aG9s

b2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+QW0uIEouIENsaW4uIFBhdGhvbC48L2FiYnItMT48YWJi

ci0yPkFtIEogQ2xpbiBQYXRob2w8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjU1LTYxPC9w

YWdlcz48dm9sdW1lPjEzOTwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5

d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVy

Z2lsbG9zaXMvKmRpYWdub3Npcy9zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVz

L2NsYXNzaWZpY2F0aW9uLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3JkPjxr

ZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkN1bHR1cmUgVGVjaG5pcXVlczwva2V5d29y

ZD48a2V5d29yZD5ETkEsIEZ1bmdhbC9hbmFseXNpczwva2V5d29yZD48a2V5d29yZD5EaWFnbm9z

dGljIEVycm9ycy8qc3RhdGlzdGljcyAmYW1wOyBudW1lcmljYWwgZGF0YTwva2V5d29yZD48a2V5

d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1h

bGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXljb2xv

Z2ljYWwgVHlwaW5nIFRlY2huaXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+UmVwcm9kdWNpYmlsaXR5

IG9mIFJlc3VsdHM8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3

b3JkPjxrZXl3b3JkPlNlcXVlbmNlIEFuYWx5c2lzLCBETkE8L2tleXdvcmQ+PGtleXdvcmQ+WW91

bmcgQWR1bHQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMzwveWVhcj48cHVi

LWRhdGVzPjxkYXRlPkphbjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE5NDMtNzcy

MiAoRWxlY3Ryb25pYykmI3hEOzAwMDItOTE3MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+MjMyNzA4OTk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6

Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjMyNzA4OTk8L3VybD48L3JlbGF0ZWQtdXJs

cz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEzMDkvQUpDUE84VlRTSzNIUk5V

VDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+

VGFycmFuZDwvQXV0aG9yPjxZZWFyPjIwMDM8L1llYXI+PFJlY051bT44MDA8L1JlY051bT48cmVj

b3JkPjxyZWMtbnVtYmVyPjgwMDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1w

PSIxNDU0MzY4NjcyIj44MDA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PlRhcnJhbmQsIEouIEouPC9hdXRob3I+PGF1dGhvcj5MaWNodGVyZmVsZCwgTS48L2F1dGhvcj48

YXV0aG9yPldhcnJhaWNoLCBJLjwvYXV0aG9yPjxhdXRob3I+THVuYSwgTS48L2F1dGhvcj48YXV0

aG9yPkhhbiwgWC4gWS48L2F1dGhvcj48YXV0aG9yPk1heSwgRy4gUy48L2F1dGhvcj48YXV0aG9y

PktvbnRveWlhbm5pcywgRC4gUC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1

dGgtYWRkcmVzcz5EaXZpc2lvbiBvZiBQYXRob2xvZ3kgYW5kIExhYm9yYXRvcnkgTWVkaWNpbmUs

IEJveCA4NCwgVW5pdmVyc2l0eSBvZiBUZXhhcyBNLkQuIEFuZGVyc29uIENhbmNlciBDZW50ZXIs

IDE1MTUgSG9sY29tYmUgQmx2ZCwgSG91c3RvbiwgVFggNzcwMzAsIFVTQS48L2F1dGgtYWRkcmVz

cz48dGl0bGVzPjx0aXRsZT5EaWFnbm9zaXMgb2YgaW52YXNpdmUgc2VwdGF0ZSBtb2xkIGluZmVj

dGlvbnMuIEEgY29ycmVsYXRpb24gb2YgbWljcm9iaW9sb2dpY2FsIGN1bHR1cmUgYW5kIGhpc3Rv

bG9naWMgb3IgY3l0b2xvZ2ljIGV4YW1pbmF0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFt

IEogQ2xpbiBQYXRob2w8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIFBhdGhvbG9neTwvZnVsbC10aXRs

ZT48YWJici0xPkFtLiBKLiBDbGluLiBQYXRob2wuPC9hYmJyLTE+PGFiYnItMj5BbSBKIENsaW4g

UGF0aG9sPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz44NTQtODwvcGFnZXM+PHZvbHVtZT4x

MTk8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QXNwZXJnaWxs

b3Npcy9kaWFnbm9zaXMvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVz

L2dyb3d0aCAmYW1wOyBkZXZlbG9wbWVudC9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9r

ZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzIGZsYXZ1cy9ncm93dGggJmFtcDsgZGV2ZWxvcG1l

bnQvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5Bc3Blcmdp

bGx1cyBmdW1pZ2F0dXMvZ3Jvd3RoICZhbXA7IGRldmVsb3BtZW50L2lzb2xhdGlvbiAmYW1wOyBw

dXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMgbmlnZXIvZ3Jvd3RoICZh

bXA7IGRldmVsb3BtZW50L2lzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtl

eXdvcmQ+QXV0b3BzeTwva2V5d29yZD48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZs

dWlkL21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5GdXNhcml1bS9ncm93dGggJmFtcDsg

ZGV2ZWxvcG1lbnQvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29y

ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBEaXNlYXNlcywgRnVuZ2FsLypkaWFnbm9z

aXMvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPk15Y29zZXMvKmRpYWdub3Npcy9taWNy

b2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3Jk

PjxrZXl3b3JkPlNjZWRvc3Bvcml1bS9ncm93dGggJmFtcDsgZGV2ZWxvcG1lbnQvaXNvbGF0aW9u

ICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAz

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlz

Ym4+MDAwMi05MTczIChQcmludCkmI3hEOzAwMDItOTE3MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MTI4MTc0MzM8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTI4MTc0MzM8L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEzMDkvRVhCVi1ZQVVQ

LUVOQk0tMjg1WTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k

Tm90ZT4A

ADDIN EN.CITE.DATA [65-67]. Moreover, these methods are time consuming and insensitive. The most common specimens obtained are lung tissue by transthoracic percutaneous needle aspiration, or video assisted thoracoscopic biopsy, and bronchial lavage/wash specimens. These specimens should be submitted in adequate quantities for both histopathologic/cytologic testing and culture with a brief clinical history to aid the pathologist and microbiologist in interpretation of findings PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HdWFybmVyPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48

UmVjTnVtPjgwMTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNjgtNzJdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjgwMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1w

PSIxNDU0MzY5MDM3Ij44MDE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

Pkd1YXJuZXIsIEouPC9hdXRob3I+PGF1dGhvcj5CcmFuZHQsIE0uIEUuPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQYXRob2xvZ3kg

YW5kIExhYm9yYXRvcnkgTWVkaWNpbmUsIEVtb3J5IFVuaXZlcnNpdHkgSG9zcGl0YWwsIEF0bGFu

dGEsIEdBIDMwMzIyLCBVU0EuIGpndWFybmVAZW1vcnkuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+SGlzdG9wYXRob2xvZ2ljIGRpYWdub3NpcyBvZiBmdW5nYWwgaW5mZWN0aW9ucyBp

biB0aGUgMjFzdCBjZW50dXJ5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW4gTWljcm9iaW9s

IFJldjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNs

aW5pY2FsIE1pY3JvYmlvbG9neSBSZXZpZXdzPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2xpbi4gTWlj

cm9iaW9sLiBSZXYuPC9hYmJyLTE+PGFiYnItMj5DbGluIE1pY3JvYmlvbCBSZXY8L2FiYnItMj48

L3BlcmlvZGljYWw+PHBhZ2VzPjI0Ny04MDwvcGFnZXM+PHZvbHVtZT4yNDwvdm9sdW1lPjxudW1i

ZXI+MjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5GdW5naS8qY3l0b2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+SGlzdG9jeXRvY2hlbWlzdHJ5LyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1

bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9oaXN0b2NoZW1pc3RyeTwva2V5d29yZD48a2V5

d29yZD5JbiBTaXR1IEh5YnJpZGl6YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+TXljb3Nlcy8qZGlh

Z25vc2lzLyptaWNyb2Jpb2xvZ3kvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlBhdGhvbG9n

eSwgTW9sZWN1bGFyL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBS

ZWFjdGlvbjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxwdWIt

ZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA5OC02NjE4

IChFbGVjdHJvbmljKSYjeEQ7MDg5My04NTEyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51

bT4yMTQ4MjcyNTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMTQ4MjcyNTwvdXJsPjwvcmVsYXRlZC11cmxz

PjwvdXJscz48Y3VzdG9tMj5QTUMzMTIyNDk1PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNl

LW51bT4xMC4xMTI4L0NNUi4wMDA1My0xMDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNv

cmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+Vnl6YW50aWFkaXM8L0F1dGhvcj48WWVhcj4yMDEyPC9Z

ZWFyPjxSZWNOdW0+ODAyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj44MDI8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVy

eHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM2OTA3NiI+ODAyPC9rZXk+PC9mb3Jl

aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj

b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5WeXphbnRpYWRpcywgVC4gQS48L2F1dGhvcj48

YXV0aG9yPkpvaG5zb24sIEUuIE0uPC9hdXRob3I+PGF1dGhvcj5LaWJibGVyLCBDLiBDLjwvYXV0

aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPjFzdCBEZXBhcnRtZW50

IG9mIE1pY3JvYmlvbG9neSwgTWVkaWNhbCBTY2hvb2wsIEFyaXN0b3RsZSBVbml2ZXJzaXR5IG9m

IFRoZXNzYWxvbmlraSwgVGhlc3NhbG9uaWtpLCBHcmVlY2UuIGF2eXpAbWVkLmF1dGguZ3I8L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Gcm9tIHRoZSBwYXRpZW50IHRvIHRoZSBjbGluaWNh

bCBteWNvbG9neSBsYWJvcmF0b3J5OiBob3cgY2FuIHdlIG9wdGltaXNlIG1pY3Jvc2NvcHkgYW5k

IGN1bHR1cmUgbWV0aG9kcyBmb3IgbW91bGQgaWRlbnRpZmljYXRpb24/PC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPkogQ2xpbiBQYXRob2w8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIFBhdGhvbG9neTwvZnVsbC10aXRs

ZT48YWJici0xPkouIENsaW4uIFBhdGhvbC48L2FiYnItMT48YWJici0yPkogQ2xpbiBQYXRob2w8

L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjQ3NS04MzwvcGFnZXM+PHZvbHVtZT42NTwvdm9s

dW1lPjxudW1iZXI+NjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5Bc3BlcmdpbGx1cy9jbGFz

c2lmaWNhdGlvbi8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbi9waHlzaW9sb2d5PC9rZXl3

b3JkPjxrZXl3b3JkPkNsYXNzaWZpY2F0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkN1bHR1cmUgVGVj

aG5pcXVlczwva2V5d29yZD48a2V5d29yZD5EYXRhYmFzZXMsIEJpYmxpb2dyYXBoaWM8L2tleXdv

cmQ+PGtleXdvcmQ+RnVzYXJpdW0vY2xhc3NpZmljYXRpb24vKmlzb2xhdGlvbiAmYW1wOyBwdXJp

ZmljYXRpb24vcGh5c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+Kk1pY3JvYmlvbG9naWNhbCBUZWNobmlxdWVzPC9rZXl3b3JkPjxrZXl3b3JkPk15Y29s

b2d5LyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPk15Y29zZXMvKmRpYWdub3Npcy9taWNyb2Jp

b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UGhlbm90eXBlPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdW48L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xNDcyLTQxNDYgKEVsZWN0cm9uaWMpJiN4RDswMDIxLTk3NDYgKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyMzA4MjY4PC9hY2Nlc3Npb24tbnVtPjx1cmxz

PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIy

MzA4MjY4PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51

bT4xMC4xMTM2L2pjbGlucGF0aC0yMDExLTIwMDUwMDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+SG9wZTwvQXV0aG9yPjxZZWFyPjIwMDU8L1ll

YXI+PFJlY051bT4xMDYyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMDYyPC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0idHZ2YWV0c3dydmUwMDNlYWV4

OTVmYXpjZWUyd2ZyZHM1ZWF6IiB0aW1lc3RhbXA9IjE0MDcxNjQ3OTgiPjEwNjI8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkhvcGUsIFcuIFcuPC9hdXRob3I+PGF1dGhv

cj5XYWxzaCwgVC4gSi48L2F1dGhvcj48YXV0aG9yPkRlbm5pbmcsIEQuIFcuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+U2Nob29sIG9mIE1lZGljaW5lLCBV

bml2ZXJzaXR5IG9mIE1hbmNoZXN0ZXIgYW5kIFd5dGhlbnNoYXdlIEhvc3BpdGFsLCBNYW5jaGVz

dGVyLCBVSy48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5MYWJvcmF0b3J5IGRpYWdub3Np

cyBvZiBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkxhbmNl

dCBJbmZlY3QgRGlzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5UaGUgTGFuY2V0IGluZmVj

dGlvdXMgZGlzZWFzZXM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRs

ZT5MYW5jZXQgSW5mZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjYwOS0y

MjwvcGFnZXM+PHZvbHVtZT41PC92b2x1bWU+PG51bWJlcj4xMDwvbnVtYmVyPjxrZXl3b3Jkcz48

a2V5d29yZD5BbnRpYm9kaWVzLCBGdW5nYWw8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Np

cy8qZGlhZ25vc2lzLypwYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvaW1t

dW5vbG9neS9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkNs

aW5pY2FsIExhYm9yYXRvcnkgVGVjaG5pcXVlczwva2V5d29yZD48a2V5d29yZD5ETkEsIEZ1bmdh

bC9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwv

a2V5d29yZD48a2V5d29yZD5NYW5uYW5zL2FuYWx5c2lzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMDU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5PY3Q8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xNDczLTMwOTkgKFByaW50KSYjeEQ7MTQ3My0zMDk5IChMaW5raW5n

KTwvaXNibj48YWNjZXNzaW9uLW51bT4xNjE4MzUxNTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVs

YXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xNjE4MzUx

NTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAu

MTAxNi9TMTQ3My0zMDk5KDA1KTcwMjM4LTM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVj

b3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkRlbm5pbmc8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFy

PjxSZWNOdW0+MTA2MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTA2MTwvcmVjLW51bWJl

cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9InR2dmFldHN3cnZlMDAzZWFleDk1

ZmF6Y2VlMndmcmRzNWVheiIgdGltZXN0YW1wPSIxNDA3MTY0NzI1Ij4xMDYxPC9rZXk+PC9mb3Jl

aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj

b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5EZW5uaW5nLCBELiBXLjwvYXV0aG9yPjxhdXRo

b3I+S2liYmxlciwgQy4gQy48L2F1dGhvcj48YXV0aG9yPkJhcm5lcywgUi4gQS48L2F1dGhvcj48

YXV0aG9yPkJyaXRpc2ggU29jaWV0eSBmb3IgTWVkaWNhbCwgTXljb2xvZ3k8L2F1dGhvcj48L2F1

dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5TY2hvb2wgb2YgTWVkaWNpbmUsIFVu

aXZlcnNpdHkgb2YgTWFuY2hlc3RlciBhbmQgV3l0aGVuc2hhd2UgSG9zcGl0YWwsIE1hbmNoZXN0

ZXIsIFVLLiBkZGVubmluZ0BtYW4uYWMudWs8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5C

cml0aXNoIFNvY2lldHkgZm9yIE1lZGljYWwgTXljb2xvZ3kgcHJvcG9zZWQgc3RhbmRhcmRzIG9m

IGNhcmUgZm9yIHBhdGllbnRzIHdpdGggaW52YXNpdmUgZnVuZ2FsIGluZmVjdGlvbnM8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+TGFuY2V0IEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48YWx0

LXRpdGxlPlRoZSBMYW5jZXQgaW5mZWN0aW91cyBkaXNlYXNlczwvYWx0LXRpdGxlPjwvdGl0bGVz

PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkxhbmNldCBJbmZlY3QgRGlzPC9mdWxsLXRpdGxlPjwv

cGVyaW9kaWNhbD48cGFnZXM+MjMwLTQwPC9wYWdlcz48dm9sdW1lPjM8L3ZvbHVtZT48bnVtYmVy

PjQ8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+R3JlYXQgQnJpdGFpbjwva2V5d29yZD48a2V5

d29yZD5IaXN0b2xvZ3kvc3RhbmRhcmRzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29y

ZD48a2V5d29yZD5NeWNvc2VzL3BhdGhvbG9neS9yYWRpb2dyYXBoeS8qdGhlcmFweTwva2V5d29y

ZD48a2V5d29yZD5RdWFsaXR5IEFzc3VyYW5jZSwgSGVhbHRoIENhcmU8L2tleXdvcmQ+PGtleXdv

cmQ+U29jaWV0aWVzLCBNZWRpY2FsPC9rZXl3b3JkPjxrZXl3b3JkPlRvbW9ncmFwaHksIFgtUmF5

IENvbXB1dGVkL3N0YW5kYXJkczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAz

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlz

Ym4+MTQ3My0zMDk5IChQcmludCkmI3hEOzE0NzMtMzA5OSAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MTI2NzkyNjY8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTI2NzkyNjY8L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QmFydG9uPC9BdXRo

b3I+PFllYXI+MjAxMzwvWWVhcj48UmVjTnVtPjExMzY8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjExMzY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJ0

dnZhZXRzd3J2ZTAwM2VhZXg5NWZhemNlZTJ3ZnJkczVlYXoiIHRpbWVzdGFtcD0iMTQwNzM1MjY3

OSI+MTEzNjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGlj

bGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QmFydG9uLCBS

LiBDLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPk15Y29s

b2d5IFJlZmVyZW5jZSBDZW50cmUsIERlcGFydG1lbnQgb2YgTWljcm9iaW9sb2d5LCBMZWVkcyBU

ZWFjaGluZyBIb3NwaXRhbHMgVHJ1c3QsIExlZWRzIExTMSAzRVgsIFVLLjwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPkxhYm9yYXRvcnkgZGlhZ25vc2lzIG9mIGludmFzaXZlIGFzcGVyZ2ls

bG9zaXM6IGZyb20gZGlhZ25vc2lzIHRvIHByZWRpY3Rpb24gb2Ygb3V0Y29tZTwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5TY2llbnRpZmljYSAoQ2Fpcm8pPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10

aXRsZT5TY2llbnRpZmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRp

dGxlPlNjaWVudGlmaWNhIChDYWlybyk8L2Z1bGwtdGl0bGU+PGFiYnItMT5TY2llbnRpZmljYTwv

YWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+U2NpZW50aWZp

Y2EgKENhaXJvKTwvZnVsbC10aXRsZT48YWJici0xPlNjaWVudGlmaWNhPC9hYmJyLTE+PC9hbHQt

cGVyaW9kaWNhbD48cGFnZXM+NDU5NDA1PC9wYWdlcz48dm9sdW1lPjIwMTM8L3ZvbHVtZT48ZGF0

ZXM+PHllYXI+MjAxMzwveWVhcj48L2RhdGVzPjxpc2JuPjIwOTAtOTA4WCAoRWxlY3Ryb25pYykm

I3hEOzIwOTAtOTA4WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjQyNzg3ODA8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0u

bmloLmdvdi9wdWJtZWQvMjQyNzg3ODA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3Rv

bTI+MzgyMDM2MTwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE1NS8yMDEz

LzQ1OTQwNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90

ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HdWFybmVyPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48

UmVjTnVtPjgwMTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNjgtNzJdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjgwMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1w

PSIxNDU0MzY5MDM3Ij44MDE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

Pkd1YXJuZXIsIEouPC9hdXRob3I+PGF1dGhvcj5CcmFuZHQsIE0uIEUuPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQYXRob2xvZ3kg

YW5kIExhYm9yYXRvcnkgTWVkaWNpbmUsIEVtb3J5IFVuaXZlcnNpdHkgSG9zcGl0YWwsIEF0bGFu

dGEsIEdBIDMwMzIyLCBVU0EuIGpndWFybmVAZW1vcnkuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+SGlzdG9wYXRob2xvZ2ljIGRpYWdub3NpcyBvZiBmdW5nYWwgaW5mZWN0aW9ucyBp

biB0aGUgMjFzdCBjZW50dXJ5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW4gTWljcm9iaW9s

IFJldjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNs

aW5pY2FsIE1pY3JvYmlvbG9neSBSZXZpZXdzPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2xpbi4gTWlj

cm9iaW9sLiBSZXYuPC9hYmJyLTE+PGFiYnItMj5DbGluIE1pY3JvYmlvbCBSZXY8L2FiYnItMj48

L3BlcmlvZGljYWw+PHBhZ2VzPjI0Ny04MDwvcGFnZXM+PHZvbHVtZT4yNDwvdm9sdW1lPjxudW1i

ZXI+MjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5GdW5naS8qY3l0b2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+SGlzdG9jeXRvY2hlbWlzdHJ5LyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1

bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9oaXN0b2NoZW1pc3RyeTwva2V5d29yZD48a2V5

d29yZD5JbiBTaXR1IEh5YnJpZGl6YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+TXljb3Nlcy8qZGlh

Z25vc2lzLyptaWNyb2Jpb2xvZ3kvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlBhdGhvbG9n

eSwgTW9sZWN1bGFyL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBS

ZWFjdGlvbjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxwdWIt

ZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA5OC02NjE4

IChFbGVjdHJvbmljKSYjeEQ7MDg5My04NTEyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51

bT4yMTQ4MjcyNTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMTQ4MjcyNTwvdXJsPjwvcmVsYXRlZC11cmxz

PjwvdXJscz48Y3VzdG9tMj5QTUMzMTIyNDk1PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNl

LW51bT4xMC4xMTI4L0NNUi4wMDA1My0xMDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNv

cmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+Vnl6YW50aWFkaXM8L0F1dGhvcj48WWVhcj4yMDEyPC9Z

ZWFyPjxSZWNOdW0+ODAyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj44MDI8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVy

eHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM2OTA3NiI+ODAyPC9rZXk+PC9mb3Jl

aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj

b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5WeXphbnRpYWRpcywgVC4gQS48L2F1dGhvcj48

YXV0aG9yPkpvaG5zb24sIEUuIE0uPC9hdXRob3I+PGF1dGhvcj5LaWJibGVyLCBDLiBDLjwvYXV0

aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPjFzdCBEZXBhcnRtZW50

IG9mIE1pY3JvYmlvbG9neSwgTWVkaWNhbCBTY2hvb2wsIEFyaXN0b3RsZSBVbml2ZXJzaXR5IG9m

IFRoZXNzYWxvbmlraSwgVGhlc3NhbG9uaWtpLCBHcmVlY2UuIGF2eXpAbWVkLmF1dGguZ3I8L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Gcm9tIHRoZSBwYXRpZW50IHRvIHRoZSBjbGluaWNh

bCBteWNvbG9neSBsYWJvcmF0b3J5OiBob3cgY2FuIHdlIG9wdGltaXNlIG1pY3Jvc2NvcHkgYW5k

IGN1bHR1cmUgbWV0aG9kcyBmb3IgbW91bGQgaWRlbnRpZmljYXRpb24/PC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPkogQ2xpbiBQYXRob2w8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIFBhdGhvbG9neTwvZnVsbC10aXRs

ZT48YWJici0xPkouIENsaW4uIFBhdGhvbC48L2FiYnItMT48YWJici0yPkogQ2xpbiBQYXRob2w8

L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjQ3NS04MzwvcGFnZXM+PHZvbHVtZT42NTwvdm9s

dW1lPjxudW1iZXI+NjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5Bc3BlcmdpbGx1cy9jbGFz

c2lmaWNhdGlvbi8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbi9waHlzaW9sb2d5PC9rZXl3

b3JkPjxrZXl3b3JkPkNsYXNzaWZpY2F0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkN1bHR1cmUgVGVj

aG5pcXVlczwva2V5d29yZD48a2V5d29yZD5EYXRhYmFzZXMsIEJpYmxpb2dyYXBoaWM8L2tleXdv

cmQ+PGtleXdvcmQ+RnVzYXJpdW0vY2xhc3NpZmljYXRpb24vKmlzb2xhdGlvbiAmYW1wOyBwdXJp

ZmljYXRpb24vcGh5c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+Kk1pY3JvYmlvbG9naWNhbCBUZWNobmlxdWVzPC9rZXl3b3JkPjxrZXl3b3JkPk15Y29s

b2d5LyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPk15Y29zZXMvKmRpYWdub3Npcy9taWNyb2Jp

b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UGhlbm90eXBlPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdW48L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xNDcyLTQxNDYgKEVsZWN0cm9uaWMpJiN4RDswMDIxLTk3NDYgKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyMzA4MjY4PC9hY2Nlc3Npb24tbnVtPjx1cmxz

PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIy

MzA4MjY4PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51

bT4xMC4xMTM2L2pjbGlucGF0aC0yMDExLTIwMDUwMDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+SG9wZTwvQXV0aG9yPjxZZWFyPjIwMDU8L1ll

YXI+PFJlY051bT4xMDYyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMDYyPC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0idHZ2YWV0c3dydmUwMDNlYWV4

OTVmYXpjZWUyd2ZyZHM1ZWF6IiB0aW1lc3RhbXA9IjE0MDcxNjQ3OTgiPjEwNjI8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkhvcGUsIFcuIFcuPC9hdXRob3I+PGF1dGhv

cj5XYWxzaCwgVC4gSi48L2F1dGhvcj48YXV0aG9yPkRlbm5pbmcsIEQuIFcuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+U2Nob29sIG9mIE1lZGljaW5lLCBV

bml2ZXJzaXR5IG9mIE1hbmNoZXN0ZXIgYW5kIFd5dGhlbnNoYXdlIEhvc3BpdGFsLCBNYW5jaGVz

dGVyLCBVSy48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5MYWJvcmF0b3J5IGRpYWdub3Np

cyBvZiBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkxhbmNl

dCBJbmZlY3QgRGlzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5UaGUgTGFuY2V0IGluZmVj

dGlvdXMgZGlzZWFzZXM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRs

ZT5MYW5jZXQgSW5mZWN0IERpczwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjYwOS0y

MjwvcGFnZXM+PHZvbHVtZT41PC92b2x1bWU+PG51bWJlcj4xMDwvbnVtYmVyPjxrZXl3b3Jkcz48

a2V5d29yZD5BbnRpYm9kaWVzLCBGdW5nYWw8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Np

cy8qZGlhZ25vc2lzLypwYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvaW1t

dW5vbG9neS9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkNs

aW5pY2FsIExhYm9yYXRvcnkgVGVjaG5pcXVlczwva2V5d29yZD48a2V5d29yZD5ETkEsIEZ1bmdh

bC9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwv

a2V5d29yZD48a2V5d29yZD5NYW5uYW5zL2FuYWx5c2lzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMDU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5PY3Q8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xNDczLTMwOTkgKFByaW50KSYjeEQ7MTQ3My0zMDk5IChMaW5raW5n

KTwvaXNibj48YWNjZXNzaW9uLW51bT4xNjE4MzUxNTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVs

YXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xNjE4MzUx

NTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAu

MTAxNi9TMTQ3My0zMDk5KDA1KTcwMjM4LTM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVj

b3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkRlbm5pbmc8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFy

PjxSZWNOdW0+MTA2MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTA2MTwvcmVjLW51bWJl

cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9InR2dmFldHN3cnZlMDAzZWFleDk1

ZmF6Y2VlMndmcmRzNWVheiIgdGltZXN0YW1wPSIxNDA3MTY0NzI1Ij4xMDYxPC9rZXk+PC9mb3Jl

aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj

b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5EZW5uaW5nLCBELiBXLjwvYXV0aG9yPjxhdXRo

b3I+S2liYmxlciwgQy4gQy48L2F1dGhvcj48YXV0aG9yPkJhcm5lcywgUi4gQS48L2F1dGhvcj48

YXV0aG9yPkJyaXRpc2ggU29jaWV0eSBmb3IgTWVkaWNhbCwgTXljb2xvZ3k8L2F1dGhvcj48L2F1

dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5TY2hvb2wgb2YgTWVkaWNpbmUsIFVu

aXZlcnNpdHkgb2YgTWFuY2hlc3RlciBhbmQgV3l0aGVuc2hhd2UgSG9zcGl0YWwsIE1hbmNoZXN0

ZXIsIFVLLiBkZGVubmluZ0BtYW4uYWMudWs8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5C

cml0aXNoIFNvY2lldHkgZm9yIE1lZGljYWwgTXljb2xvZ3kgcHJvcG9zZWQgc3RhbmRhcmRzIG9m

IGNhcmUgZm9yIHBhdGllbnRzIHdpdGggaW52YXNpdmUgZnVuZ2FsIGluZmVjdGlvbnM8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+TGFuY2V0IEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48YWx0

LXRpdGxlPlRoZSBMYW5jZXQgaW5mZWN0aW91cyBkaXNlYXNlczwvYWx0LXRpdGxlPjwvdGl0bGVz

PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkxhbmNldCBJbmZlY3QgRGlzPC9mdWxsLXRpdGxlPjwv

cGVyaW9kaWNhbD48cGFnZXM+MjMwLTQwPC9wYWdlcz48dm9sdW1lPjM8L3ZvbHVtZT48bnVtYmVy

PjQ8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+R3JlYXQgQnJpdGFpbjwva2V5d29yZD48a2V5

d29yZD5IaXN0b2xvZ3kvc3RhbmRhcmRzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29y

ZD48a2V5d29yZD5NeWNvc2VzL3BhdGhvbG9neS9yYWRpb2dyYXBoeS8qdGhlcmFweTwva2V5d29y

ZD48a2V5d29yZD5RdWFsaXR5IEFzc3VyYW5jZSwgSGVhbHRoIENhcmU8L2tleXdvcmQ+PGtleXdv

cmQ+U29jaWV0aWVzLCBNZWRpY2FsPC9rZXl3b3JkPjxrZXl3b3JkPlRvbW9ncmFwaHksIFgtUmF5

IENvbXB1dGVkL3N0YW5kYXJkczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAz

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlz

Ym4+MTQ3My0zMDk5IChQcmludCkmI3hEOzE0NzMtMzA5OSAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MTI2NzkyNjY8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTI2NzkyNjY8L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QmFydG9uPC9BdXRo

b3I+PFllYXI+MjAxMzwvWWVhcj48UmVjTnVtPjExMzY8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjExMzY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJ0

dnZhZXRzd3J2ZTAwM2VhZXg5NWZhemNlZTJ3ZnJkczVlYXoiIHRpbWVzdGFtcD0iMTQwNzM1MjY3

OSI+MTEzNjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGlj

bGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QmFydG9uLCBS

LiBDLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPk15Y29s

b2d5IFJlZmVyZW5jZSBDZW50cmUsIERlcGFydG1lbnQgb2YgTWljcm9iaW9sb2d5LCBMZWVkcyBU

ZWFjaGluZyBIb3NwaXRhbHMgVHJ1c3QsIExlZWRzIExTMSAzRVgsIFVLLjwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPkxhYm9yYXRvcnkgZGlhZ25vc2lzIG9mIGludmFzaXZlIGFzcGVyZ2ls

bG9zaXM6IGZyb20gZGlhZ25vc2lzIHRvIHByZWRpY3Rpb24gb2Ygb3V0Y29tZTwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5TY2llbnRpZmljYSAoQ2Fpcm8pPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10

aXRsZT5TY2llbnRpZmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRp

dGxlPlNjaWVudGlmaWNhIChDYWlybyk8L2Z1bGwtdGl0bGU+PGFiYnItMT5TY2llbnRpZmljYTwv

YWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+U2NpZW50aWZp

Y2EgKENhaXJvKTwvZnVsbC10aXRsZT48YWJici0xPlNjaWVudGlmaWNhPC9hYmJyLTE+PC9hbHQt

cGVyaW9kaWNhbD48cGFnZXM+NDU5NDA1PC9wYWdlcz48dm9sdW1lPjIwMTM8L3ZvbHVtZT48ZGF0

ZXM+PHllYXI+MjAxMzwveWVhcj48L2RhdGVzPjxpc2JuPjIwOTAtOTA4WCAoRWxlY3Ryb25pYykm

I3hEOzIwOTAtOTA4WCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjQyNzg3ODA8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0u

bmloLmdvdi9wdWJtZWQvMjQyNzg3ODA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3Rv

bTI+MzgyMDM2MTwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE1NS8yMDEz

LzQ1OTQwNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90

ZT5=

ADDIN EN.CITE.DATA [68-72]. Methods to optimize yield should be employed including adequate quantity of specimens, timely delivery of fresh specimen to the laboratory, or refrigeration if delay is anticipated (although refrigeration may reduce the recovery of some organisms like the Mucorales), incubation of cultures for at least 5 days (and up to 3 weeks for other fungal pathogens) and communication of suspicion for fungal infection with pathology and microbiology laboratory personnel ADDIN EN.CITE <EndNote><Cite><Author>Labarca</Author><Year>1998</Year><RecNum>1111</RecNum><DisplayText>[73]</DisplayText><record><rec-number>1111</rec-number><foreign-keys><key app="EN" db-id="25ws99rfnw2zfmert5rxzapsprpa5wr2efdr" timestamp="1459876285">1111</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Labarca, J. A.</author><author>Wagar, E. A.</author><author>Grasmick, A. E.</author><author>Kokkinos, H. M.</author><author>Bruckner, D. A.</author></authors></contributors><auth-address>Department of Pathology and Laboratory Medicine, Clinical Microbiology Laboratory, UCLA Medical Center, University of California, Los Angeles, California, USA. jlabarca@ucla.edu</auth-address><titles><title>Critical evaluation of 4-week incubation for fungal cultures: is the fourth week useful?</title><secondary-title>J Clin Microbiol</secondary-title></titles><periodical><full-title>Journal of Clinical Microbiology</full-title><abbr-1>J. Clin. Microbiol.</abbr-1><abbr-2>J Clin Microbiol</abbr-2></periodical><pages>3683-5</pages><volume>36</volume><number>12</number><keywords><keyword>Fungi/*growth &amp; development/isolation &amp; purification</keyword><keyword>Humans</keyword><keyword>Retrospective Studies</keyword><keyword>Time Factors</keyword></keywords><dates><year>1998</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>0095-1137 (Print)&#xD;0095-1137 (Linking)</isbn><accession-num>9817896</accession-num><urls><related-urls><url>;[73]. In the pathology laboratory, standard and special fungal stains on fluid or tissue should be performed simultaneously when a fungal infection is suspected and may reveal the characteristic acute angle branching septate hyphae of Aspergillus spp. Molecular assays targeting ribosomal DNA sequences can also be used for detection of Aspergillus in tissues, although these methods have not been standardized nor cleared by the FDA for clinical use. The optical brightener methods, Calcofluor or Blankophor, are rapid stains utilized for direct examination and have a high sensitivity and specificity for detecting Aspergillus-like features PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbmRyZWFzPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48

UmVjTnVtPjgwMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNzQsIDc1XTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj44MDM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFt

cD0iMTQ1NDM2OTQ2NCI+ODAzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5BbmRyZWFzLCBTLjwvYXV0aG9yPjxhdXRob3I+SGVpbmRsLCBTLjwvYXV0aG9yPjxhdXRob3I+

V2F0dGt5LCBDLjwvYXV0aG9yPjxhdXRob3I+TW9sbGVyLCBLLjwvYXV0aG9yPjxhdXRob3I+UnVj

aGVsLCBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRl

cHQgb2YgQ2FyZGlvbG9neSBhbmQgUG5ldW1vbG9neSwgR2VvcmctQXVndXN0LVVuaXZlcnNpdHks

IEdvdHRpbmdlbiwgR2VybWFueS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EaWFnbm9z

aXMgb2YgcHVsbW9uYXJ5IGFzcGVyZ2lsbG9zaXMgdXNpbmcgb3B0aWNhbCBicmlnaHRlbmVyczwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgUmVzcGlyIEo8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXJvcGVhbiBSZXNwaXJhdG9yeSBKb3VybmFs

PC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyLiBSZXNwaXIuIEouPC9hYmJyLTE+PGFiYnItMj5FdXIg

UmVzcGlyIEo8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjQwNy0xMTwvcGFnZXM+PHZvbHVt

ZT4xNTwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5Bc3Blcmdp

bGxvc2lzLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+QnJvbmNob2FsdmVvbGFyIExhdmFn

ZSBGbHVpZC9jaGVtaXN0cnkvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkNvbG9yaW5n

IEFnZW50czwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBE

aXNlYXNlcywgRnVuZ2FsLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8

L2tleXdvcmQ+PGtleXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9rZXl3b3JkPjxr

ZXl3b3JkPlNwZWNpbWVuIEhhbmRsaW5nPC9rZXl3b3JkPjxrZXl3b3JkPlN0YWluaW5nIGFuZCBM

YWJlbGluZzwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAwPC95ZWFyPjxwdWIt

ZGF0ZXM+PGRhdGU+RmViPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDkwMy0xOTM2

IChQcmludCkmI3hEOzA5MDMtMTkzNiAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTA3

MDY1MTI8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTA3MDY1MTI8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy

bHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+Q2hhbmRlcjwvQXV0aG9yPjxZZWFyPjE5

OTM8L1llYXI+PFJlY051bT4xMTMyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMTMyPC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0idHZ2YWV0c3dydmUw

MDNlYWV4OTVmYXpjZWUyd2ZyZHM1ZWF6IiB0aW1lc3RhbXA9IjE0MDczNDg4NTkiPjExMzI8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNoYW5kZXIsIEouPC9hdXRob3I+

PGF1dGhvcj5DaGFrcmFiYXJ0aSwgQS48L2F1dGhvcj48YXV0aG9yPlNoYXJtYSwgQS48L2F1dGhv

cj48YXV0aG9yPlNhaW5pLCBKLiBTLjwvYXV0aG9yPjxhdXRob3I+UGFuaWdhcmhpLCBELjwvYXV0

aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2Yg

TWVkaWNhbCBNaWNyb2Jpb2xvZ3ksIFBvc3RncmFkdWF0ZSBJbnN0aXR1dGUgb2YgTWVkaWNhbCBF

ZHVjYXRpb24gYW5kIFJlc2VhcmNoLCBDaGFuZGlnYXJoLCBJbmRpYS48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5FdmFsdWF0aW9uIG9mIENhbGNvZmx1b3Igc3RhaW5pbmcgaW4gdGhlIGRp

YWdub3NpcyBvZiBmdW5nYWwgY29ybmVhbCB1bGNlcjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5N

eWNvc2VzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5NeWNvc2VzPC9hbHQtdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TXljb3NlczwvZnVsbC10aXRsZT48L3Blcmlv

ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk15Y29zZXM8L2Z1bGwtdGl0bGU+PC9h

bHQtcGVyaW9kaWNhbD48cGFnZXM+MjQzLTU8L3BhZ2VzPjx2b2x1bWU+MzY8L3ZvbHVtZT48bnVt

YmVyPjctODwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5Db3JuZWEvbWljcm9iaW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPkNvcm5lYWwgVWxjZXIvKmRpYWdub3Npczwva2V5d29yZD48a2V5d29y

ZD5FeWUgSW5mZWN0aW9ucywgRnVuZ2FsLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+Rmx1

b3Jlc2NlbnQgRHllcy8qZGlhZ25vc3RpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+RnVuZ2kvZ3Jv

d3RoICZhbXA7IGRldmVsb3BtZW50L2lzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb248L2tleXdv

cmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkh5ZHJveGlkZXM8L2tleXdvcmQ+

PGtleXdvcmQ+TWljcm9zY29weSwgRmx1b3Jlc2NlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPk15Y29s

b2dpY2FsIFR5cGluZyBUZWNobmlxdWVzPC9rZXl3b3JkPjxrZXl3b3JkPk9yZ2FuaWMgQ2hlbWlj

YWxzPC9rZXl3b3JkPjxrZXl3b3JkPlBvdGFzc2l1bSBDb21wb3VuZHM8L2tleXdvcmQ+PGtleXdv

cmQ+U3RhaW5pbmcgYW5kIExhYmVsaW5nPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy

PjE5OTM8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdWwtQXVnPC9kYXRlPjwvcHViLWRhdGVzPjwv

ZGF0ZXM+PGlzYm4+MDkzMy03NDA3IChQcmludCkmI3hEOzA5MzMtNzQwNyAoTGlua2luZyk8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+NzUwOTQ1MzwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11

cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC83NTA5NDUzPC91cmw+

PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbmRyZWFzPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48

UmVjTnVtPjgwMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNzQsIDc1XTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj44MDM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFt

cD0iMTQ1NDM2OTQ2NCI+ODAzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5BbmRyZWFzLCBTLjwvYXV0aG9yPjxhdXRob3I+SGVpbmRsLCBTLjwvYXV0aG9yPjxhdXRob3I+

V2F0dGt5LCBDLjwvYXV0aG9yPjxhdXRob3I+TW9sbGVyLCBLLjwvYXV0aG9yPjxhdXRob3I+UnVj

aGVsLCBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRl

cHQgb2YgQ2FyZGlvbG9neSBhbmQgUG5ldW1vbG9neSwgR2VvcmctQXVndXN0LVVuaXZlcnNpdHks

IEdvdHRpbmdlbiwgR2VybWFueS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EaWFnbm9z

aXMgb2YgcHVsbW9uYXJ5IGFzcGVyZ2lsbG9zaXMgdXNpbmcgb3B0aWNhbCBicmlnaHRlbmVyczwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgUmVzcGlyIEo8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXJvcGVhbiBSZXNwaXJhdG9yeSBKb3VybmFs

PC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyLiBSZXNwaXIuIEouPC9hYmJyLTE+PGFiYnItMj5FdXIg

UmVzcGlyIEo8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjQwNy0xMTwvcGFnZXM+PHZvbHVt

ZT4xNTwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5Bc3Blcmdp

bGxvc2lzLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+QnJvbmNob2FsdmVvbGFyIExhdmFn

ZSBGbHVpZC9jaGVtaXN0cnkvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkNvbG9yaW5n

IEFnZW50czwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBE

aXNlYXNlcywgRnVuZ2FsLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8

L2tleXdvcmQ+PGtleXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9rZXl3b3JkPjxr

ZXl3b3JkPlNwZWNpbWVuIEhhbmRsaW5nPC9rZXl3b3JkPjxrZXl3b3JkPlN0YWluaW5nIGFuZCBM

YWJlbGluZzwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAwPC95ZWFyPjxwdWIt

ZGF0ZXM+PGRhdGU+RmViPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDkwMy0xOTM2

IChQcmludCkmI3hEOzA5MDMtMTkzNiAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTA3

MDY1MTI8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTA3MDY1MTI8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy

bHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+Q2hhbmRlcjwvQXV0aG9yPjxZZWFyPjE5

OTM8L1llYXI+PFJlY051bT4xMTMyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMTMyPC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0idHZ2YWV0c3dydmUw

MDNlYWV4OTVmYXpjZWUyd2ZyZHM1ZWF6IiB0aW1lc3RhbXA9IjE0MDczNDg4NTkiPjExMzI8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNoYW5kZXIsIEouPC9hdXRob3I+

PGF1dGhvcj5DaGFrcmFiYXJ0aSwgQS48L2F1dGhvcj48YXV0aG9yPlNoYXJtYSwgQS48L2F1dGhv

cj48YXV0aG9yPlNhaW5pLCBKLiBTLjwvYXV0aG9yPjxhdXRob3I+UGFuaWdhcmhpLCBELjwvYXV0

aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2Yg

TWVkaWNhbCBNaWNyb2Jpb2xvZ3ksIFBvc3RncmFkdWF0ZSBJbnN0aXR1dGUgb2YgTWVkaWNhbCBF

ZHVjYXRpb24gYW5kIFJlc2VhcmNoLCBDaGFuZGlnYXJoLCBJbmRpYS48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5FdmFsdWF0aW9uIG9mIENhbGNvZmx1b3Igc3RhaW5pbmcgaW4gdGhlIGRp

YWdub3NpcyBvZiBmdW5nYWwgY29ybmVhbCB1bGNlcjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5N

eWNvc2VzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5NeWNvc2VzPC9hbHQtdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TXljb3NlczwvZnVsbC10aXRsZT48L3Blcmlv

ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk15Y29zZXM8L2Z1bGwtdGl0bGU+PC9h

bHQtcGVyaW9kaWNhbD48cGFnZXM+MjQzLTU8L3BhZ2VzPjx2b2x1bWU+MzY8L3ZvbHVtZT48bnVt

YmVyPjctODwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5Db3JuZWEvbWljcm9iaW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPkNvcm5lYWwgVWxjZXIvKmRpYWdub3Npczwva2V5d29yZD48a2V5d29y

ZD5FeWUgSW5mZWN0aW9ucywgRnVuZ2FsLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+Rmx1

b3Jlc2NlbnQgRHllcy8qZGlhZ25vc3RpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+RnVuZ2kvZ3Jv

d3RoICZhbXA7IGRldmVsb3BtZW50L2lzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb248L2tleXdv

cmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkh5ZHJveGlkZXM8L2tleXdvcmQ+

PGtleXdvcmQ+TWljcm9zY29weSwgRmx1b3Jlc2NlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPk15Y29s

b2dpY2FsIFR5cGluZyBUZWNobmlxdWVzPC9rZXl3b3JkPjxrZXl3b3JkPk9yZ2FuaWMgQ2hlbWlj

YWxzPC9rZXl3b3JkPjxrZXl3b3JkPlBvdGFzc2l1bSBDb21wb3VuZHM8L2tleXdvcmQ+PGtleXdv

cmQ+U3RhaW5pbmcgYW5kIExhYmVsaW5nPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy

PjE5OTM8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdWwtQXVnPC9kYXRlPjwvcHViLWRhdGVzPjwv

ZGF0ZXM+PGlzYm4+MDkzMy03NDA3IChQcmludCkmI3hEOzA5MzMtNzQwNyAoTGlua2luZyk8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+NzUwOTQ1MzwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11

cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC83NTA5NDUzPC91cmw+

PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA [74, 75]. Special stains on fixed tissue include Gomori methenamine silver (GMS) stain (also referred to as Grocott Gomori) and Periodic Acid Schiff (PAS) stains. However, no histopathologic finding can definitively diagnose the pathogen, and confirmation by culture or non-culture technique is necessary to distinguish Aspergillus from other filamentous fungi such as Fusarium spp. and Scedosporium spp. Additionally, atypical appearances of the organism may be seen in tissue, particularly in patients receiving antifungal therapy. Increasingly, DNA sequencing is being used in reference laboratories to identify “cryptic” species that are misidentified by microscopic appearance or only identified to the complex level. Some of these species are more resistant to azole antifungal agents. Aspergillus spp. grow well on most media at 37°C at 2-5 days, and methods should include fungal specific media. Despite this, culture yield is low and a negative culture does not exclude the diagnosis of IA PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3J0ZW5zZW48L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFy

PjxSZWNOdW0+ODA0PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls3Nl08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+ODA0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9

IjE0NTQzNzAwNzMiPjgwNDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

TW9ydGVuc2VuLCBLLiBMLjwvYXV0aG9yPjxhdXRob3I+Sm9oYW5zZW4sIEguIEsuPC9hdXRob3I+

PGF1dGhvcj5GdXVyc3RlZCwgSy48L2F1dGhvcj48YXV0aG9yPktudWRzZW4sIEouIEQuPC9hdXRo

b3I+PGF1dGhvcj5HYWhybi1IYW5zZW4sIEIuPC9hdXRob3I+PGF1dGhvcj5KZW5zZW4sIFIuIEgu

PC9hdXRob3I+PGF1dGhvcj5Ib3dhcmQsIFMuIEouPC9hdXRob3I+PGF1dGhvcj5BcmVuZHJ1cCwg

TS4gQy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NeWNv

bG9neSBVbml0LCBEZXBhcnRtZW50IG9mIE1pY3JvYmlvbG9naWNhbCBTdXJ2ZWlsbGFuY2UgYW5k

IFJlc2VhcmNoLCBTdGF0ZW5zIFNlcnVtIEluc3RpdHV0LCBBcnRpbGxlcml2ZWogNSwgREstMjMw

MCBDb3BlbmhhZ2VuIFMsIERlbm1hcmsuIGtsbUBzc2kuZGs8L2F1dGgtYWRkcmVzcz48dGl0bGVz

Pjx0aXRsZT5BIHByb3NwZWN0aXZlIHN1cnZleSBvZiBBc3BlcmdpbGx1cyBzcHAuIGluIHJlc3Bp

cmF0b3J5IHRyYWN0IHNhbXBsZXM6IHByZXZhbGVuY2UsIGNsaW5pY2FsIGltcGFjdCBhbmQgYW50

aWZ1bmdhbCBzdXNjZXB0aWJpbGl0eTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSiBDbGlu

IE1pY3JvYmlvbCBJbmZlY3QgRGlzPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+RXVyb3BlYW4gSm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3kg

YW5kIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXIuIEouIENsaW4u

IE1pY3JvYmlvbC4gSW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5FdXIgSiBDbGluIE1pY3Jv

YmlvbCBJbmZlY3QgRGlzPC9hYmJyLTI+PGFiYnItMz5FdXJvcGVhbiBKb3VybmFsIG9mIENsaW5p

Y2FsIE1pY3JvYmlvbG9neSAmYW1wOyBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9hYmJyLTM+PC9wZXJp

b2RpY2FsPjxwYWdlcz4xMzU1LTYzPC9wYWdlcz48dm9sdW1lPjMwPC92b2x1bWU+PG51bWJlcj4x

MTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3Jk

PkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAg

YW5kIG92ZXI8L2tleXdvcmQ+PGtleXdvcmQ+QW1waG90ZXJpY2luIEIvcGhhcm1hY29sb2d5L3Ro

ZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy8qcGhhcm1h

Y29sb2d5L3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2Rp

YWdub3Npcy9kcnVnIHRoZXJhcHkvKmVwaWRlbWlvbG9neS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+QXNwZXJnaWxsdXMvZHJ1ZyBlZmZlY3RzLyppc29sYXRpb24gJmFtcDsgcHVyaWZp

Y2F0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkLCBQ

cmVzY2hvb2w8L2tleXdvcmQ+PGtleXdvcmQ+RGVubWFyay9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+RHJ1ZyBSZXNpc3RhbmNlLCBGdW5nYWwvZHJ1ZyBlZmZlY3RzPC9rZXl3b3JkPjxr

ZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Ib3NwaXRhbHM8L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkl0cmFjb25hem9sZS9waGFybWFjb2xvZ3kvdGhl

cmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlj

cm9iaWFsIFNlbnNpdGl2aXR5IFRlc3RzPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9r

ZXl3b3JkPjxrZXl3b3JkPlByZXZhbGVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUg

U3R1ZGllczwva2V5d29yZD48a2V5d29yZD5QeXJpbWlkaW5lcy9waGFybWFjb2xvZ3kvdGhlcmFw

ZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IFN5c3RlbS8qbWljcm9iaW9s

b2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IFRyYWN0IEluZmVjdGlvbnMvZGlhZ25v

c2lzL2RydWcgdGhlcmFweS8qZXBpZGVtaW9sb2d5L21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5

d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5Ucmlhem9sZXMvcGhhcm1h

Y29sb2d5L3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Wb3JpY29uYXpvbGU8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRl

Pk5vdjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0MzUtNDM3MyAoRWxlY3Ryb25p

YykmI3hEOzA5MzQtOTcyMyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjE1NDE2NzE8

L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5u

bG0ubmloLmdvdi9wdWJtZWQvMjE1NDE2NzE8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMDcvczEwMDk2LTAxMS0xMjI5LTc8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3J0ZW5zZW48L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFy

PjxSZWNOdW0+ODA0PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls3Nl08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+ODA0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9

IjE0NTQzNzAwNzMiPjgwNDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

TW9ydGVuc2VuLCBLLiBMLjwvYXV0aG9yPjxhdXRob3I+Sm9oYW5zZW4sIEguIEsuPC9hdXRob3I+

PGF1dGhvcj5GdXVyc3RlZCwgSy48L2F1dGhvcj48YXV0aG9yPktudWRzZW4sIEouIEQuPC9hdXRo

b3I+PGF1dGhvcj5HYWhybi1IYW5zZW4sIEIuPC9hdXRob3I+PGF1dGhvcj5KZW5zZW4sIFIuIEgu

PC9hdXRob3I+PGF1dGhvcj5Ib3dhcmQsIFMuIEouPC9hdXRob3I+PGF1dGhvcj5BcmVuZHJ1cCwg

TS4gQy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NeWNv

bG9neSBVbml0LCBEZXBhcnRtZW50IG9mIE1pY3JvYmlvbG9naWNhbCBTdXJ2ZWlsbGFuY2UgYW5k

IFJlc2VhcmNoLCBTdGF0ZW5zIFNlcnVtIEluc3RpdHV0LCBBcnRpbGxlcml2ZWogNSwgREstMjMw

MCBDb3BlbmhhZ2VuIFMsIERlbm1hcmsuIGtsbUBzc2kuZGs8L2F1dGgtYWRkcmVzcz48dGl0bGVz

Pjx0aXRsZT5BIHByb3NwZWN0aXZlIHN1cnZleSBvZiBBc3BlcmdpbGx1cyBzcHAuIGluIHJlc3Bp

cmF0b3J5IHRyYWN0IHNhbXBsZXM6IHByZXZhbGVuY2UsIGNsaW5pY2FsIGltcGFjdCBhbmQgYW50

aWZ1bmdhbCBzdXNjZXB0aWJpbGl0eTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXIgSiBDbGlu

IE1pY3JvYmlvbCBJbmZlY3QgRGlzPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+RXVyb3BlYW4gSm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3kg

YW5kIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXIuIEouIENsaW4u

IE1pY3JvYmlvbC4gSW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5FdXIgSiBDbGluIE1pY3Jv

YmlvbCBJbmZlY3QgRGlzPC9hYmJyLTI+PGFiYnItMz5FdXJvcGVhbiBKb3VybmFsIG9mIENsaW5p

Y2FsIE1pY3JvYmlvbG9neSAmYW1wOyBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9hYmJyLTM+PC9wZXJp

b2RpY2FsPjxwYWdlcz4xMzU1LTYzPC9wYWdlcz48dm9sdW1lPjMwPC92b2x1bWU+PG51bWJlcj4x

MTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3Jk

PkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAg

YW5kIG92ZXI8L2tleXdvcmQ+PGtleXdvcmQ+QW1waG90ZXJpY2luIEIvcGhhcm1hY29sb2d5L3Ro

ZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy8qcGhhcm1h

Y29sb2d5L3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2Rp

YWdub3Npcy9kcnVnIHRoZXJhcHkvKmVwaWRlbWlvbG9neS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+QXNwZXJnaWxsdXMvZHJ1ZyBlZmZlY3RzLyppc29sYXRpb24gJmFtcDsgcHVyaWZp

Y2F0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkLCBQ

cmVzY2hvb2w8L2tleXdvcmQ+PGtleXdvcmQ+RGVubWFyay9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+RHJ1ZyBSZXNpc3RhbmNlLCBGdW5nYWwvZHJ1ZyBlZmZlY3RzPC9rZXl3b3JkPjxr

ZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Ib3NwaXRhbHM8L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkl0cmFjb25hem9sZS9waGFybWFjb2xvZ3kvdGhl

cmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlj

cm9iaWFsIFNlbnNpdGl2aXR5IFRlc3RzPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9r

ZXl3b3JkPjxrZXl3b3JkPlByZXZhbGVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUg

U3R1ZGllczwva2V5d29yZD48a2V5d29yZD5QeXJpbWlkaW5lcy9waGFybWFjb2xvZ3kvdGhlcmFw

ZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IFN5c3RlbS8qbWljcm9iaW9s

b2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IFRyYWN0IEluZmVjdGlvbnMvZGlhZ25v

c2lzL2RydWcgdGhlcmFweS8qZXBpZGVtaW9sb2d5L21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5

d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5Ucmlhem9sZXMvcGhhcm1h

Y29sb2d5L3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Wb3JpY29uYXpvbGU8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRl

Pk5vdjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0MzUtNDM3MyAoRWxlY3Ryb25p

YykmI3hEOzA5MzQtOTcyMyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjE1NDE2NzE8

L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5u

bG0ubmloLmdvdi9wdWJtZWQvMjE1NDE2NzE8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMDcvczEwMDk2LTAxMS0xMjI5LTc8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA [76]. This low yield notwithstanding, culture is critical for species complex identification and susceptibility testing where feasible until molecular methods are more routinely performed in clinical laboratories.What is the diagnostic value of nucleic acid testing in clinical specimens?Recommendations7.There was debate among the committee members regarding the clinical utility of blood-based PCR in diagnosing IA and experts were not in agreement.? One group favored recommendations for PCR testing, based on publications validating its?role when used in conjunction with other tests such as antigen detection assays to diagnose IA and/or reduce pre-emptive antifungal usage.? The other group felt that PCR assays are promising, but could not be recommended for routine use in clinical practice at present due to the lack of conclusive validation for commercially available assays, the variety of?methodologies in the literature, and questions about the extent to which results assisted diagnosis.???8.As research in the area continues, we recommend that clinicians?choosing to?use PCR assays employ them carefully in the management of individual patients on a case-by-case basis.? Clinicians should be aware of the methodologies and performance?characteristics of the specific assay used, and interpret results accordingly.?When PCR assays are used, results should be considered in conjunction with other diagnostic tests and the clinical context (Strong Recommendation; Moderate Quality Evidence).?Evidence summarySince the last IDSA guidelines, there have been numerous publications assessing the performance of Aspergillus PCR in clinical samples. Overall, direct comparison studies have shown Aspergillus PCR to be substantially more sensitive than culture in blood and respiratory fluids. In a meta-analysis of clinical trials evaluating the accuracy of serum or whole-blood PCR assays for IA, sensitivity and specificity were 84% and 76%, respectively PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BcnZhbml0aXM8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy

PjxSZWNOdW0+ODA1PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls3N108L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+ODA1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9

IjE0NTQzNzAxMzkiPjgwNTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

QXJ2YW5pdGlzLCBNLjwvYXV0aG9yPjxhdXRob3I+Wmlha2FzLCBQLiBELjwvYXV0aG9yPjxhdXRo

b3I+WmFjaGFyaW91ZGFraXMsIEkuIE0uPC9hdXRob3I+PGF1dGhvcj5aZXJ2b3UsIEYuIE4uPC9h

dXRob3I+PGF1dGhvcj5DYWxpZW5kbywgQS4gTS48L2F1dGhvcj48YXV0aG9yPk15bG9uYWtpcywg

RS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5JbmZlY3Rp

b3VzIERpc2Vhc2VzIERpdmlzaW9uLCBSaG9kZSBJc2xhbmQgSG9zcGl0YWwsIFByb3ZpZGVuY2Us

IFJob2RlIElzbGFuZCwgVVNBIFdhcnJlbiBBbHBlcnQgTWVkaWNhbCBTY2hvb2wgb2YgQnJvd24g

VW5pdmVyc2l0eSwgUHJvdmlkZW5jZSwgUmhvZGUgSXNsYW5kLCBVU0EuJiN4RDtJbmZlY3Rpb3Vz

IERpc2Vhc2VzIERpdmlzaW9uLCBSaG9kZSBJc2xhbmQgSG9zcGl0YWwsIFByb3ZpZGVuY2UsIFJo

b2RlIElzbGFuZCwgVVNBIFdhcnJlbiBBbHBlcnQgTWVkaWNhbCBTY2hvb2wgb2YgQnJvd24gVW5p

dmVyc2l0eSwgUHJvdmlkZW5jZSwgUmhvZGUgSXNsYW5kLCBVU0EgZW15bG9uYWtpc0BsaWZlc3Bh

bi5vcmcuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UENSIGluIGRpYWdub3NpcyBvZiBp

bnZhc2l2ZSBhc3BlcmdpbGxvc2lzOiBhIG1ldGEtYW5hbHlzaXMgb2YgZGlhZ25vc3RpYyBwZXJm

b3JtYW5jZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIENsaW4gTWljcm9iaW9sPC9zZWNvbmRh

cnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGlu

aWNhbCBNaWNyb2Jpb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KLiBDbGluLiBNaWNyb2Jpb2wu

PC9hYmJyLTE+PGFiYnItMj5KIENsaW4gTWljcm9iaW9sPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxw

YWdlcz4zNzMxLTQyPC9wYWdlcz48dm9sdW1lPjUyPC92b2x1bWU+PG51bWJlcj4xMDwvbnVtYmVy

PjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy9n

ZW5ldGljcy8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5C

bG9vZC9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdv

cmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5IZW1hdG9sb2dpYyBOZW9wbGFz

bXMvY29tcGxpY2F0aW9uczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv

cmQ+SW52YXNpdmUgUHVsbW9uYXJ5IEFzcGVyZ2lsbG9zaXMvKmRpYWdub3Npczwva2V5d29yZD48

a2V5d29yZD5Nb2xlY3VsYXIgRGlhZ25vc3RpYyBUZWNobmlxdWVzLyptZXRob2RzPC9rZXl3b3Jk

PjxrZXl3b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb24vKm1ldGhvZHM8L2tleXdvcmQ+PGtl

eXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5PY3Q8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xMDk4LTY2MFggKEVsZWN0cm9uaWMpJiN4RDswMDk1LTExMzcgKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI1MTIyODU0PC9hY2Nlc3Npb24tbnVtPjx1cmxz

PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI1

MTIyODU0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzQxODc3NzA8L2N1

c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMjgvSkNNLjAxMzY1LTE0PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BcnZhbml0aXM8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy

PjxSZWNOdW0+ODA1PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls3N108L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+ODA1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9

IjE0NTQzNzAxMzkiPjgwNTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

QXJ2YW5pdGlzLCBNLjwvYXV0aG9yPjxhdXRob3I+Wmlha2FzLCBQLiBELjwvYXV0aG9yPjxhdXRo

b3I+WmFjaGFyaW91ZGFraXMsIEkuIE0uPC9hdXRob3I+PGF1dGhvcj5aZXJ2b3UsIEYuIE4uPC9h

dXRob3I+PGF1dGhvcj5DYWxpZW5kbywgQS4gTS48L2F1dGhvcj48YXV0aG9yPk15bG9uYWtpcywg

RS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5JbmZlY3Rp

b3VzIERpc2Vhc2VzIERpdmlzaW9uLCBSaG9kZSBJc2xhbmQgSG9zcGl0YWwsIFByb3ZpZGVuY2Us

IFJob2RlIElzbGFuZCwgVVNBIFdhcnJlbiBBbHBlcnQgTWVkaWNhbCBTY2hvb2wgb2YgQnJvd24g

VW5pdmVyc2l0eSwgUHJvdmlkZW5jZSwgUmhvZGUgSXNsYW5kLCBVU0EuJiN4RDtJbmZlY3Rpb3Vz

IERpc2Vhc2VzIERpdmlzaW9uLCBSaG9kZSBJc2xhbmQgSG9zcGl0YWwsIFByb3ZpZGVuY2UsIFJo

b2RlIElzbGFuZCwgVVNBIFdhcnJlbiBBbHBlcnQgTWVkaWNhbCBTY2hvb2wgb2YgQnJvd24gVW5p

dmVyc2l0eSwgUHJvdmlkZW5jZSwgUmhvZGUgSXNsYW5kLCBVU0EgZW15bG9uYWtpc0BsaWZlc3Bh

bi5vcmcuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UENSIGluIGRpYWdub3NpcyBvZiBp

bnZhc2l2ZSBhc3BlcmdpbGxvc2lzOiBhIG1ldGEtYW5hbHlzaXMgb2YgZGlhZ25vc3RpYyBwZXJm

b3JtYW5jZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIENsaW4gTWljcm9iaW9sPC9zZWNvbmRh

cnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGlu

aWNhbCBNaWNyb2Jpb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KLiBDbGluLiBNaWNyb2Jpb2wu

PC9hYmJyLTE+PGFiYnItMj5KIENsaW4gTWljcm9iaW9sPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxw

YWdlcz4zNzMxLTQyPC9wYWdlcz48dm9sdW1lPjUyPC92b2x1bWU+PG51bWJlcj4xMDwvbnVtYmVy

PjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy9n

ZW5ldGljcy8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5C

bG9vZC9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdv

cmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5IZW1hdG9sb2dpYyBOZW9wbGFz

bXMvY29tcGxpY2F0aW9uczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv

cmQ+SW52YXNpdmUgUHVsbW9uYXJ5IEFzcGVyZ2lsbG9zaXMvKmRpYWdub3Npczwva2V5d29yZD48

a2V5d29yZD5Nb2xlY3VsYXIgRGlhZ25vc3RpYyBUZWNobmlxdWVzLyptZXRob2RzPC9rZXl3b3Jk

PjxrZXl3b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb24vKm1ldGhvZHM8L2tleXdvcmQ+PGtl

eXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5PY3Q8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xMDk4LTY2MFggKEVsZWN0cm9uaWMpJiN4RDswMDk1LTExMzcgKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI1MTIyODU0PC9hY2Nlc3Npb24tbnVtPjx1cmxz

PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI1

MTIyODU0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzQxODc3NzA8L2N1

c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMjgvSkNNLjAxMzY1LTE0PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [77]. These values are promising, but PCR of blood or serum is unable on its own to confirm or exclude suspected IA in high-risk patients. The sensitivity of Aspergillus PCR on BAL fluid was higher than within blood, but in many instances its specificity was lower PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bdm5pPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

TnVtPjgwNjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNzgsIDc5XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj44MDY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0i

MTQ1NDM3MDQ1NyI+ODA2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5B

dm5pLCBULjwvYXV0aG9yPjxhdXRob3I+TGV2eSwgSS48L2F1dGhvcj48YXV0aG9yPlNwcmVjaGVy

LCBILjwvYXV0aG9yPjxhdXRob3I+WWFoYXYsIEQuPC9hdXRob3I+PGF1dGhvcj5MZWlib3ZpY2ks

IEwuPC9hdXRob3I+PGF1dGhvcj5QYXVsLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPk1lZGljaW5lIEUsIFJhYmluIE1lZGljYWwgQ2VudGVyLCBCZWls

aW5zb24gSG9zcGl0YWwsIFBldGFoLVRpa3ZhLCBJc3JhZWwuPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RGlhZ25vc3RpYyBhY2N1cmFjeSBvZiBQQ1IgYWxvbmUgY29tcGFyZWQgdG8gZ2Fs

YWN0b21hbm5hbiBpbiBicm9uY2hvYWx2ZW9sYXIgbGF2YWdlIGZsdWlkIGZvciBkaWFnbm9zaXMg

b2YgaW52YXNpdmUgcHVsbW9uYXJ5IGFzcGVyZ2lsbG9zaXM6IGEgc3lzdGVtYXRpYyByZXZpZXc8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBDbGluIE1pY3JvYmlvbDwvc2Vjb25kYXJ5LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgTWlj

cm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQ2xpbi4gTWljcm9iaW9sLjwvYWJici0x

PjxhYmJyLTI+SiBDbGluIE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MzY1

Mi04PC9wYWdlcz48dm9sdW1lPjUwPC92b2x1bWU+PG51bWJlcj4xMTwvbnVtYmVyPjxrZXl3b3Jk

cz48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkLyptaWNyb2Jpb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+Q2FzZS1Db250cm9sIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+Q2xp

bmljYWwgTGFib3JhdG9yeSBUZWNobmlxdWVzLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1

bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9hc3NheS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3

b3JkPkludmFzaXZlIFB1bG1vbmFyeSBBc3BlcmdpbGxvc2lzLypkaWFnbm9zaXM8L2tleXdvcmQ+

PGtleXdvcmQ+TWFubmFucy8qYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+TXljb2xvZ3kvKm1l

dGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBSZWFjdGlvbi8qbWV0aG9k

czwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3Jk

PlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQg

U3BlY2lmaWNpdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMjwveWVhcj48

cHViLWRhdGVzPjxkYXRlPk5vdjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwOTgt

NjYwWCAoRWxlY3Ryb25pYykmI3hEOzAwOTUtMTEzNyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MjI5NTIyNjg8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjI5NTIyNjg8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PGN1c3RvbTI+UE1DMzQ4NjIyNTwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTEyOC9KQ00uMDA5NDItMTI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhlbmc8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy

PjxSZWNOdW0+ODA3PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj44MDc8L3JlYy1udW1iZXI+

PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHph

cHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM3MDUxMyI+ODA3PC9rZXk+PC9mb3JlaWdu

LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250

cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IZW5nLCBTLiBDLjwvYXV0aG9yPjxhdXRob3I+TW9y

cmlzc2V5LCBPLjwvYXV0aG9yPjxhdXRob3I+Q2hlbiwgUy4gQy48L2F1dGhvcj48YXV0aG9yPlRo

dXJza3ksIEsuPC9hdXRob3I+PGF1dGhvcj5NYW5zZXIsIFIuIEwuPC9hdXRob3I+PGF1dGhvcj5O

YXRpb24sIFIuIEwuPC9hdXRob3I+PGF1dGhvcj5Lb25nLCBELiBDLjwvYXV0aG9yPjxhdXRob3I+

U2xhdmluLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNz

Pk1vbmFzaCBVbml2ZXJzaXR5ICwgTWVsYm91cm5lICwgQXVzdHJhbGlhIC48L2F1dGgtYWRkcmVz

cz48dGl0bGVzPjx0aXRsZT5VdGlsaXR5IG9mIGJyb25jaG9hbHZlb2xhciBsYXZhZ2UgZmx1aWQg

Z2FsYWN0b21hbm5hbiBhbG9uZSBvciBpbiBjb21iaW5hdGlvbiB3aXRoIFBDUiBmb3IgdGhlIGRp

YWdub3NpcyBvZiBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIGluIGFkdWx0IGhlbWF0b2xvZ3kgcGF0

aWVudHM6IGEgc3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXM8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+Q3JpdCBSZXYgTWljcm9iaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q3JpdGljYWwgUmV2aWV3cyBpbiBNaWNyb2Jpb2xvZ3k8

L2Z1bGwtdGl0bGU+PGFiYnItMT5Dcml0LiBSZXYuIE1pY3JvYmlvbC48L2FiYnItMT48YWJici0y

PkNyaXQgUmV2IE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MTI0LTM0PC9w

YWdlcz48dm9sdW1lPjQxPC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3

b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvY29tcGxpY2F0aW9ucy8q

ZGlhZ25vc2lzL21ldGFib2xpc20vbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkJyb25j

aG9hbHZlb2xhciBMYXZhZ2UgRmx1aWQvKmNoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5IZW1h

dG9sb2dpYyBOZW9wbGFzbXMvKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z

PC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvKmFuYWx5c2lzL2Jsb29kPC9rZXl3b3JkPjxrZXl3

b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb24vKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+

U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9z

aXM8L2tleXdvcmQ+PGtleXdvcmQ+QkFMIGdhbGFjdG9tYW5uYW48L2tleXdvcmQ+PGtleXdvcmQ+

aGVtYXRvbG9neTwva2V5d29yZD48a2V5d29yZD5tZXRhLWFuYWx5c2lzPC9rZXl3b3JkPjwva2V5

d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5GZWI8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTQ5LTc4MjggKEVsZWN0cm9uaWMpJiN4RDsxMDQw

LTg0MVggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIzNzk5ODcxPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3Yv

cHVibWVkLzIzNzk5ODcxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJl

c291cmNlLW51bT4xMC4zMTA5LzEwNDA4NDFYLjIwMTMuODA0MDMzPC9lbGVjdHJvbmljLXJlc291

cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bdm5pPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

TnVtPjgwNjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNzgsIDc5XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj44MDY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0i

MTQ1NDM3MDQ1NyI+ODA2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5B

dm5pLCBULjwvYXV0aG9yPjxhdXRob3I+TGV2eSwgSS48L2F1dGhvcj48YXV0aG9yPlNwcmVjaGVy

LCBILjwvYXV0aG9yPjxhdXRob3I+WWFoYXYsIEQuPC9hdXRob3I+PGF1dGhvcj5MZWlib3ZpY2ks

IEwuPC9hdXRob3I+PGF1dGhvcj5QYXVsLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPk1lZGljaW5lIEUsIFJhYmluIE1lZGljYWwgQ2VudGVyLCBCZWls

aW5zb24gSG9zcGl0YWwsIFBldGFoLVRpa3ZhLCBJc3JhZWwuPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RGlhZ25vc3RpYyBhY2N1cmFjeSBvZiBQQ1IgYWxvbmUgY29tcGFyZWQgdG8gZ2Fs

YWN0b21hbm5hbiBpbiBicm9uY2hvYWx2ZW9sYXIgbGF2YWdlIGZsdWlkIGZvciBkaWFnbm9zaXMg

b2YgaW52YXNpdmUgcHVsbW9uYXJ5IGFzcGVyZ2lsbG9zaXM6IGEgc3lzdGVtYXRpYyByZXZpZXc8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBDbGluIE1pY3JvYmlvbDwvc2Vjb25kYXJ5LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgTWlj

cm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQ2xpbi4gTWljcm9iaW9sLjwvYWJici0x

PjxhYmJyLTI+SiBDbGluIE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MzY1

Mi04PC9wYWdlcz48dm9sdW1lPjUwPC92b2x1bWU+PG51bWJlcj4xMTwvbnVtYmVyPjxrZXl3b3Jk

cz48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkLyptaWNyb2Jpb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+Q2FzZS1Db250cm9sIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+Q2xp

bmljYWwgTGFib3JhdG9yeSBUZWNobmlxdWVzLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1

bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9hc3NheS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3

b3JkPkludmFzaXZlIFB1bG1vbmFyeSBBc3BlcmdpbGxvc2lzLypkaWFnbm9zaXM8L2tleXdvcmQ+

PGtleXdvcmQ+TWFubmFucy8qYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+TXljb2xvZ3kvKm1l

dGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBSZWFjdGlvbi8qbWV0aG9k

czwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3Jk

PlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQg

U3BlY2lmaWNpdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMjwveWVhcj48

cHViLWRhdGVzPjxkYXRlPk5vdjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwOTgt

NjYwWCAoRWxlY3Ryb25pYykmI3hEOzAwOTUtMTEzNyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MjI5NTIyNjg8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjI5NTIyNjg8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PGN1c3RvbTI+UE1DMzQ4NjIyNTwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTEyOC9KQ00uMDA5NDItMTI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhlbmc8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy

PjxSZWNOdW0+ODA3PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj44MDc8L3JlYy1udW1iZXI+

PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHph

cHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM3MDUxMyI+ODA3PC9rZXk+PC9mb3JlaWdu

LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250

cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IZW5nLCBTLiBDLjwvYXV0aG9yPjxhdXRob3I+TW9y

cmlzc2V5LCBPLjwvYXV0aG9yPjxhdXRob3I+Q2hlbiwgUy4gQy48L2F1dGhvcj48YXV0aG9yPlRo

dXJza3ksIEsuPC9hdXRob3I+PGF1dGhvcj5NYW5zZXIsIFIuIEwuPC9hdXRob3I+PGF1dGhvcj5O

YXRpb24sIFIuIEwuPC9hdXRob3I+PGF1dGhvcj5Lb25nLCBELiBDLjwvYXV0aG9yPjxhdXRob3I+

U2xhdmluLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNz

Pk1vbmFzaCBVbml2ZXJzaXR5ICwgTWVsYm91cm5lICwgQXVzdHJhbGlhIC48L2F1dGgtYWRkcmVz

cz48dGl0bGVzPjx0aXRsZT5VdGlsaXR5IG9mIGJyb25jaG9hbHZlb2xhciBsYXZhZ2UgZmx1aWQg

Z2FsYWN0b21hbm5hbiBhbG9uZSBvciBpbiBjb21iaW5hdGlvbiB3aXRoIFBDUiBmb3IgdGhlIGRp

YWdub3NpcyBvZiBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIGluIGFkdWx0IGhlbWF0b2xvZ3kgcGF0

aWVudHM6IGEgc3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXM8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+Q3JpdCBSZXYgTWljcm9iaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q3JpdGljYWwgUmV2aWV3cyBpbiBNaWNyb2Jpb2xvZ3k8

L2Z1bGwtdGl0bGU+PGFiYnItMT5Dcml0LiBSZXYuIE1pY3JvYmlvbC48L2FiYnItMT48YWJici0y

PkNyaXQgUmV2IE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MTI0LTM0PC9w

YWdlcz48dm9sdW1lPjQxPC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3

b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvY29tcGxpY2F0aW9ucy8q

ZGlhZ25vc2lzL21ldGFib2xpc20vbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkJyb25j

aG9hbHZlb2xhciBMYXZhZ2UgRmx1aWQvKmNoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5IZW1h

dG9sb2dpYyBOZW9wbGFzbXMvKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z

PC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvKmFuYWx5c2lzL2Jsb29kPC9rZXl3b3JkPjxrZXl3

b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb24vKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+

U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9z

aXM8L2tleXdvcmQ+PGtleXdvcmQ+QkFMIGdhbGFjdG9tYW5uYW48L2tleXdvcmQ+PGtleXdvcmQ+

aGVtYXRvbG9neTwva2V5d29yZD48a2V5d29yZD5tZXRhLWFuYWx5c2lzPC9rZXl3b3JkPjwva2V5

d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5GZWI8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTQ5LTc4MjggKEVsZWN0cm9uaWMpJiN4RDsxMDQw

LTg0MVggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIzNzk5ODcxPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3Yv

cHVibWVkLzIzNzk5ODcxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJl

c291cmNlLW51bT4xMC4zMTA5LzEwNDA4NDFYLjIwMTMuODA0MDMzPC9lbGVjdHJvbmljLXJlc291

cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [78, 79] . In a systematic review of nine studies using reference IA definitions strictly adherent to the EORTC/MSG criteria, the sensitivity and specificity of PCR of BAL were 77% and 94%, respectively ADDIN EN.CITE <EndNote><Cite><Author>Avni</Author><Year>2012</Year><RecNum>806</RecNum><DisplayText>[78]</DisplayText><record><rec-number>806</rec-number><foreign-keys><key app="EN" db-id="25ws99rfnw2zfmert5rxzapsprpa5wr2efdr" timestamp="1454370457">806</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Avni, T.</author><author>Levy, I.</author><author>Sprecher, H.</author><author>Yahav, D.</author><author>Leibovici, L.</author><author>Paul, M.</author></authors></contributors><auth-address>Medicine E, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel.</auth-address><titles><title>Diagnostic accuracy of PCR alone compared to galactomannan in bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis: a systematic review</title><secondary-title>J Clin Microbiol</secondary-title></titles><periodical><full-title>Journal of Clinical Microbiology</full-title><abbr-1>J. Clin. Microbiol.</abbr-1><abbr-2>J Clin Microbiol</abbr-2></periodical><pages>3652-8</pages><volume>50</volume><number>11</number><keywords><keyword>Bronchoalveolar Lavage Fluid/*microbiology</keyword><keyword>Case-Control Studies</keyword><keyword>Clinical Laboratory Techniques/*methods</keyword><keyword>Humans</keyword><keyword>Immunoassay/methods</keyword><keyword>Invasive Pulmonary Aspergillosis/*diagnosis</keyword><keyword>Mannans/*analysis</keyword><keyword>Mycology/*methods</keyword><keyword>Polymerase Chain Reaction/*methods</keyword><keyword>Prospective Studies</keyword><keyword>Retrospective Studies</keyword><keyword>Sensitivity and Specificity</keyword></keywords><dates><year>2012</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1098-660X (Electronic)&#xD;0095-1137 (Linking)</isbn><accession-num>22952268</accession-num><urls><related-urls><url>;[78] . Data included large 95% confidence intervals that were attributed to the use of different PCR assays and inclusion of heterogeneous patient populations PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bdm5pPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

TnVtPjgwNjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNzgsIDc5XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj44MDY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0i

MTQ1NDM3MDQ1NyI+ODA2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5B

dm5pLCBULjwvYXV0aG9yPjxhdXRob3I+TGV2eSwgSS48L2F1dGhvcj48YXV0aG9yPlNwcmVjaGVy

LCBILjwvYXV0aG9yPjxhdXRob3I+WWFoYXYsIEQuPC9hdXRob3I+PGF1dGhvcj5MZWlib3ZpY2ks

IEwuPC9hdXRob3I+PGF1dGhvcj5QYXVsLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPk1lZGljaW5lIEUsIFJhYmluIE1lZGljYWwgQ2VudGVyLCBCZWls

aW5zb24gSG9zcGl0YWwsIFBldGFoLVRpa3ZhLCBJc3JhZWwuPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RGlhZ25vc3RpYyBhY2N1cmFjeSBvZiBQQ1IgYWxvbmUgY29tcGFyZWQgdG8gZ2Fs

YWN0b21hbm5hbiBpbiBicm9uY2hvYWx2ZW9sYXIgbGF2YWdlIGZsdWlkIGZvciBkaWFnbm9zaXMg

b2YgaW52YXNpdmUgcHVsbW9uYXJ5IGFzcGVyZ2lsbG9zaXM6IGEgc3lzdGVtYXRpYyByZXZpZXc8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBDbGluIE1pY3JvYmlvbDwvc2Vjb25kYXJ5LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgTWlj

cm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQ2xpbi4gTWljcm9iaW9sLjwvYWJici0x

PjxhYmJyLTI+SiBDbGluIE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MzY1

Mi04PC9wYWdlcz48dm9sdW1lPjUwPC92b2x1bWU+PG51bWJlcj4xMTwvbnVtYmVyPjxrZXl3b3Jk

cz48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkLyptaWNyb2Jpb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+Q2FzZS1Db250cm9sIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+Q2xp

bmljYWwgTGFib3JhdG9yeSBUZWNobmlxdWVzLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1

bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9hc3NheS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3

b3JkPkludmFzaXZlIFB1bG1vbmFyeSBBc3BlcmdpbGxvc2lzLypkaWFnbm9zaXM8L2tleXdvcmQ+

PGtleXdvcmQ+TWFubmFucy8qYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+TXljb2xvZ3kvKm1l

dGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBSZWFjdGlvbi8qbWV0aG9k

czwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3Jk

PlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQg

U3BlY2lmaWNpdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMjwveWVhcj48

cHViLWRhdGVzPjxkYXRlPk5vdjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwOTgt

NjYwWCAoRWxlY3Ryb25pYykmI3hEOzAwOTUtMTEzNyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MjI5NTIyNjg8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjI5NTIyNjg8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PGN1c3RvbTI+UE1DMzQ4NjIyNTwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTEyOC9KQ00uMDA5NDItMTI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhlbmc8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy

PjxSZWNOdW0+ODA3PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj44MDc8L3JlYy1udW1iZXI+

PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHph

cHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM3MDUxMyI+ODA3PC9rZXk+PC9mb3JlaWdu

LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250

cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IZW5nLCBTLiBDLjwvYXV0aG9yPjxhdXRob3I+TW9y

cmlzc2V5LCBPLjwvYXV0aG9yPjxhdXRob3I+Q2hlbiwgUy4gQy48L2F1dGhvcj48YXV0aG9yPlRo

dXJza3ksIEsuPC9hdXRob3I+PGF1dGhvcj5NYW5zZXIsIFIuIEwuPC9hdXRob3I+PGF1dGhvcj5O

YXRpb24sIFIuIEwuPC9hdXRob3I+PGF1dGhvcj5Lb25nLCBELiBDLjwvYXV0aG9yPjxhdXRob3I+

U2xhdmluLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNz

Pk1vbmFzaCBVbml2ZXJzaXR5ICwgTWVsYm91cm5lICwgQXVzdHJhbGlhIC48L2F1dGgtYWRkcmVz

cz48dGl0bGVzPjx0aXRsZT5VdGlsaXR5IG9mIGJyb25jaG9hbHZlb2xhciBsYXZhZ2UgZmx1aWQg

Z2FsYWN0b21hbm5hbiBhbG9uZSBvciBpbiBjb21iaW5hdGlvbiB3aXRoIFBDUiBmb3IgdGhlIGRp

YWdub3NpcyBvZiBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIGluIGFkdWx0IGhlbWF0b2xvZ3kgcGF0

aWVudHM6IGEgc3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXM8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+Q3JpdCBSZXYgTWljcm9iaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q3JpdGljYWwgUmV2aWV3cyBpbiBNaWNyb2Jpb2xvZ3k8

L2Z1bGwtdGl0bGU+PGFiYnItMT5Dcml0LiBSZXYuIE1pY3JvYmlvbC48L2FiYnItMT48YWJici0y

PkNyaXQgUmV2IE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MTI0LTM0PC9w

YWdlcz48dm9sdW1lPjQxPC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3

b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvY29tcGxpY2F0aW9ucy8q

ZGlhZ25vc2lzL21ldGFib2xpc20vbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkJyb25j

aG9hbHZlb2xhciBMYXZhZ2UgRmx1aWQvKmNoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5IZW1h

dG9sb2dpYyBOZW9wbGFzbXMvKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z

PC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvKmFuYWx5c2lzL2Jsb29kPC9rZXl3b3JkPjxrZXl3

b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb24vKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+

U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9z

aXM8L2tleXdvcmQ+PGtleXdvcmQ+QkFMIGdhbGFjdG9tYW5uYW48L2tleXdvcmQ+PGtleXdvcmQ+

aGVtYXRvbG9neTwva2V5d29yZD48a2V5d29yZD5tZXRhLWFuYWx5c2lzPC9rZXl3b3JkPjwva2V5

d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5GZWI8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTQ5LTc4MjggKEVsZWN0cm9uaWMpJiN4RDsxMDQw

LTg0MVggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIzNzk5ODcxPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3Yv

cHVibWVkLzIzNzk5ODcxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJl

c291cmNlLW51bT4xMC4zMTA5LzEwNDA4NDFYLjIwMTMuODA0MDMzPC9lbGVjdHJvbmljLXJlc291

cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bdm5pPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

TnVtPjgwNjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bNzgsIDc5XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj44MDY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0i

MTQ1NDM3MDQ1NyI+ODA2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5B

dm5pLCBULjwvYXV0aG9yPjxhdXRob3I+TGV2eSwgSS48L2F1dGhvcj48YXV0aG9yPlNwcmVjaGVy

LCBILjwvYXV0aG9yPjxhdXRob3I+WWFoYXYsIEQuPC9hdXRob3I+PGF1dGhvcj5MZWlib3ZpY2ks

IEwuPC9hdXRob3I+PGF1dGhvcj5QYXVsLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPk1lZGljaW5lIEUsIFJhYmluIE1lZGljYWwgQ2VudGVyLCBCZWls

aW5zb24gSG9zcGl0YWwsIFBldGFoLVRpa3ZhLCBJc3JhZWwuPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RGlhZ25vc3RpYyBhY2N1cmFjeSBvZiBQQ1IgYWxvbmUgY29tcGFyZWQgdG8gZ2Fs

YWN0b21hbm5hbiBpbiBicm9uY2hvYWx2ZW9sYXIgbGF2YWdlIGZsdWlkIGZvciBkaWFnbm9zaXMg

b2YgaW52YXNpdmUgcHVsbW9uYXJ5IGFzcGVyZ2lsbG9zaXM6IGEgc3lzdGVtYXRpYyByZXZpZXc8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBDbGluIE1pY3JvYmlvbDwvc2Vjb25kYXJ5LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgTWlj

cm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQ2xpbi4gTWljcm9iaW9sLjwvYWJici0x

PjxhYmJyLTI+SiBDbGluIE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MzY1

Mi04PC9wYWdlcz48dm9sdW1lPjUwPC92b2x1bWU+PG51bWJlcj4xMTwvbnVtYmVyPjxrZXl3b3Jk

cz48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkLyptaWNyb2Jpb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+Q2FzZS1Db250cm9sIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+Q2xp

bmljYWwgTGFib3JhdG9yeSBUZWNobmlxdWVzLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1

bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9hc3NheS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3

b3JkPkludmFzaXZlIFB1bG1vbmFyeSBBc3BlcmdpbGxvc2lzLypkaWFnbm9zaXM8L2tleXdvcmQ+

PGtleXdvcmQ+TWFubmFucy8qYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+TXljb2xvZ3kvKm1l

dGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBSZWFjdGlvbi8qbWV0aG9k

czwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3Jk

PlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQg

U3BlY2lmaWNpdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMjwveWVhcj48

cHViLWRhdGVzPjxkYXRlPk5vdjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwOTgt

NjYwWCAoRWxlY3Ryb25pYykmI3hEOzAwOTUtMTEzNyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MjI5NTIyNjg8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjI5NTIyNjg8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PGN1c3RvbTI+UE1DMzQ4NjIyNTwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTEyOC9KQ00uMDA5NDItMTI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhlbmc8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy

PjxSZWNOdW0+ODA3PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj44MDc8L3JlYy1udW1iZXI+

PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHph

cHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM3MDUxMyI+ODA3PC9rZXk+PC9mb3JlaWdu

LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250

cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IZW5nLCBTLiBDLjwvYXV0aG9yPjxhdXRob3I+TW9y

cmlzc2V5LCBPLjwvYXV0aG9yPjxhdXRob3I+Q2hlbiwgUy4gQy48L2F1dGhvcj48YXV0aG9yPlRo

dXJza3ksIEsuPC9hdXRob3I+PGF1dGhvcj5NYW5zZXIsIFIuIEwuPC9hdXRob3I+PGF1dGhvcj5O

YXRpb24sIFIuIEwuPC9hdXRob3I+PGF1dGhvcj5Lb25nLCBELiBDLjwvYXV0aG9yPjxhdXRob3I+

U2xhdmluLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNz

Pk1vbmFzaCBVbml2ZXJzaXR5ICwgTWVsYm91cm5lICwgQXVzdHJhbGlhIC48L2F1dGgtYWRkcmVz

cz48dGl0bGVzPjx0aXRsZT5VdGlsaXR5IG9mIGJyb25jaG9hbHZlb2xhciBsYXZhZ2UgZmx1aWQg

Z2FsYWN0b21hbm5hbiBhbG9uZSBvciBpbiBjb21iaW5hdGlvbiB3aXRoIFBDUiBmb3IgdGhlIGRp

YWdub3NpcyBvZiBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIGluIGFkdWx0IGhlbWF0b2xvZ3kgcGF0

aWVudHM6IGEgc3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXM8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+Q3JpdCBSZXYgTWljcm9iaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q3JpdGljYWwgUmV2aWV3cyBpbiBNaWNyb2Jpb2xvZ3k8

L2Z1bGwtdGl0bGU+PGFiYnItMT5Dcml0LiBSZXYuIE1pY3JvYmlvbC48L2FiYnItMT48YWJici0y

PkNyaXQgUmV2IE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MTI0LTM0PC9w

YWdlcz48dm9sdW1lPjQxPC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3

b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvY29tcGxpY2F0aW9ucy8q

ZGlhZ25vc2lzL21ldGFib2xpc20vbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkJyb25j

aG9hbHZlb2xhciBMYXZhZ2UgRmx1aWQvKmNoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5IZW1h

dG9sb2dpYyBOZW9wbGFzbXMvKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z

PC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvKmFuYWx5c2lzL2Jsb29kPC9rZXl3b3JkPjxrZXl3

b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb24vKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+

U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9z

aXM8L2tleXdvcmQ+PGtleXdvcmQ+QkFMIGdhbGFjdG9tYW5uYW48L2tleXdvcmQ+PGtleXdvcmQ+

aGVtYXRvbG9neTwva2V5d29yZD48a2V5d29yZD5tZXRhLWFuYWx5c2lzPC9rZXl3b3JkPjwva2V5

d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5GZWI8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTQ5LTc4MjggKEVsZWN0cm9uaWMpJiN4RDsxMDQw

LTg0MVggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIzNzk5ODcxPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3Yv

cHVibWVkLzIzNzk5ODcxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJl

c291cmNlLW51bT4xMC4zMTA5LzEwNDA4NDFYLjIwMTMuODA0MDMzPC9lbGVjdHJvbmljLXJlc291

cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [78, 79]. The lower specificity in BAL has been attributed to the fact that lungs are often colonized by Aspergillus (particularly in many high-risk populations, such as lung transplant recipients), and that PCR is not able to differentiate colonization from disease or to distinguish different Aspergillus spp. The high negative predictive value of BAL PCR (usually ≥95%) suggests a role in ruling out IPA. To date, data suggest that the diagnostic performance of blood or BAL PCR is comparable to that of serum and BAL GM index (GMI; ratio of the optical densities (OD) of the patient samples to the mean OD of control samples) of ≥0.5, respectively, and that sensitivity for both tests is affected by antifungal use. Using both PCR and GM in serum resulted in improved sensitivity with no sacrifice of specificity ADDIN EN.CITE <EndNote><Cite><Author>Avni</Author><Year>2012</Year><RecNum>806</RecNum><DisplayText>[78]</DisplayText><record><rec-number>806</rec-number><foreign-keys><key app="EN" db-id="25ws99rfnw2zfmert5rxzapsprpa5wr2efdr" timestamp="1454370457">806</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Avni, T.</author><author>Levy, I.</author><author>Sprecher, H.</author><author>Yahav, D.</author><author>Leibovici, L.</author><author>Paul, M.</author></authors></contributors><auth-address>Medicine E, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel.</auth-address><titles><title>Diagnostic accuracy of PCR alone compared to galactomannan in bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis: a systematic review</title><secondary-title>J Clin Microbiol</secondary-title></titles><periodical><full-title>Journal of Clinical Microbiology</full-title><abbr-1>J. Clin. Microbiol.</abbr-1><abbr-2>J Clin Microbiol</abbr-2></periodical><pages>3652-8</pages><volume>50</volume><number>11</number><keywords><keyword>Bronchoalveolar Lavage Fluid/*microbiology</keyword><keyword>Case-Control Studies</keyword><keyword>Clinical Laboratory Techniques/*methods</keyword><keyword>Humans</keyword><keyword>Immunoassay/methods</keyword><keyword>Invasive Pulmonary Aspergillosis/*diagnosis</keyword><keyword>Mannans/*analysis</keyword><keyword>Mycology/*methods</keyword><keyword>Polymerase Chain Reaction/*methods</keyword><keyword>Prospective Studies</keyword><keyword>Retrospective Studies</keyword><keyword>Sensitivity and Specificity</keyword></keywords><dates><year>2012</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1098-660X (Electronic)&#xD;0095-1137 (Linking)</isbn><accession-num>22952268</accession-num><urls><related-urls><url>;[78]. Clinical trials incorporating biomarkers into the management of adults with hematologic malignancies or allogeneic HSCT have shown that the combined GM and PCR reduced use of antifungal treatment PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3JyaXNzZXk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy

PjxSZWNOdW0+MjcwPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls4MF08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MjcwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9

IjE0MTM4NDgyNDciPjI3MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

TW9ycmlzc2V5LCBDLiBPLjwvYXV0aG9yPjxhdXRob3I+Q2hlbiwgUy4gQy48L2F1dGhvcj48YXV0

aG9yPlNvcnJlbGwsIFQuIEMuPC9hdXRob3I+PGF1dGhvcj5NaWxsaWtlbiwgUy48L2F1dGhvcj48

YXV0aG9yPkJhcmR5LCBQLiBHLjwvYXV0aG9yPjxhdXRob3I+QnJhZHN0b2NrLCBLLiBGLjwvYXV0

aG9yPjxhdXRob3I+U3plciwgSi48L2F1dGhvcj48YXV0aG9yPkhhbGxpZGF5LCBDLiBMLjwvYXV0

aG9yPjxhdXRob3I+R2lscm95LCBOLiBNLjwvYXV0aG9yPjxhdXRob3I+TW9vcmUsIEouPC9hdXRo

b3I+PGF1dGhvcj5TY2h3YXJlciwgQS4gUC48L2F1dGhvcj48YXV0aG9yPkd1eSwgUy48L2F1dGhv

cj48YXV0aG9yPkJhamVsLCBBLjwvYXV0aG9yPjxhdXRob3I+VHJhbW9udGFuYSwgQS4gUi48L2F1

dGhvcj48YXV0aG9yPlNwZWxtYW4sIFQuPC9hdXRob3I+PGF1dGhvcj5TbGF2aW4sIE0uIEEuPC9h

dXRob3I+PGF1dGhvcj5BdXN0cmFsYXNpYW4gTGV1a2FlbWlhIEx5bXBob21hLCBHcm91cDwvYXV0

aG9yPjxhdXRob3I+dGhlLCBBdXN0cmFsaWE8L2F1dGhvcj48YXV0aG9yPk5ldyBaZWFsYW5kIE15

Y29sb2d5IEludGVyZXN0LCBHcm91cDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

YXV0aC1hZGRyZXNzPkluZmVjdGlvdXMgRGlzZWFzZXMgVW5pdCwgQWxmcmVkIEhlYWx0aCwgYW5k

IERlcGFydG1lbnQgb2YgSW5mZWN0aW91cyBEaXNlYXNlcywgQ2VudHJhbCBDbGluaWNhbCBTY2hv

b2wsIE1vbmFzaCBVbml2ZXJzaXR5LCBNZWxib3VybmUsIFZJQywgQXVzdHJhbGlhLiBvLm1vcnJp

c3NleUBhbGZyZWQub3JnLmF1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R2FsYWN0b21h

bm5hbiBhbmQgUENSIHZlcnN1cyBjdWx0dXJlIGFuZCBoaXN0b2xvZ3kgZm9yIGRpcmVjdGluZyB1

c2Ugb2YgYW50aWZ1bmdhbCB0cmVhdG1lbnQgZm9yIGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgaW4g

aGlnaC1yaXNrIGhhZW1hdG9sb2d5IHBhdGllbnRzOiBhIHJhbmRvbWlzZWQgY29udHJvbGxlZCB0

cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5MYW5jZXQgSW5mZWN0IERpczwvc2Vjb25kYXJ5

LXRpdGxlPjxhbHQtdGl0bGU+VGhlIExhbmNldC4gSW5mZWN0aW91cyBkaXNlYXNlczwvYWx0LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkxhbmNldCBJbmZlY3Rpb3VzIERp

c2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+TGFuY2V0IEluZmVjdC4gRGlzLjwvYWJici0xPjxh

YmJyLTI+TGFuY2V0IEluZmVjdCBEaXM8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjUxOS0y

ODwvcGFnZXM+PHZvbHVtZT4xMzwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxrZXl3b3Jkcz48

a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy8qdGhlcmFw

ZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvZGlhZ25vc2lzLypkcnVn

IHRoZXJhcHkvKm1ldGFib2xpc20vcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2ls

bHVzLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uL3BhdGhvZ2VuaWNpdHk8L2tleXdvcmQ+

PGtleXdvcmQ+QmlvbG9naWNhbCBNYXJrZXJzL21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+

RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3

b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5MZXVrZW1pYSwgTHltcGhvaWQvZHJ1ZyB0aGVy

YXB5LyptaWNyb2Jpb2xvZ3kvc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPk1hbm5hbnMvKm1ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFn

ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBSZWFjdGlvbi8qbWV0aG9kczwv

a2V5d29yZD48a2V5d29yZD5TdGVtIENlbGwgVHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3

b3JkPlRyYW5zcGxhbnRhdGlvbiwgSG9tb2xvZ291czwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDEzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuPC9kYXRlPjwvcHViLWRhdGVz

PjwvZGF0ZXM+PGlzYm4+MTQ3NC00NDU3IChFbGVjdHJvbmljKSYjeEQ7MTQ3My0zMDk5IChMaW5r

aW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMzYzOTYxMjwvYWNjZXNzaW9uLW51bT48dXJscz48

cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMzYz

OTYxMjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTAxNi9TMTQ3My0zMDk5KDEzKTcwMDc2LTg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3JyaXNzZXk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy

PjxSZWNOdW0+MjcwPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls4MF08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MjcwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9

IjE0MTM4NDgyNDciPjI3MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

TW9ycmlzc2V5LCBDLiBPLjwvYXV0aG9yPjxhdXRob3I+Q2hlbiwgUy4gQy48L2F1dGhvcj48YXV0

aG9yPlNvcnJlbGwsIFQuIEMuPC9hdXRob3I+PGF1dGhvcj5NaWxsaWtlbiwgUy48L2F1dGhvcj48

YXV0aG9yPkJhcmR5LCBQLiBHLjwvYXV0aG9yPjxhdXRob3I+QnJhZHN0b2NrLCBLLiBGLjwvYXV0

aG9yPjxhdXRob3I+U3plciwgSi48L2F1dGhvcj48YXV0aG9yPkhhbGxpZGF5LCBDLiBMLjwvYXV0

aG9yPjxhdXRob3I+R2lscm95LCBOLiBNLjwvYXV0aG9yPjxhdXRob3I+TW9vcmUsIEouPC9hdXRo

b3I+PGF1dGhvcj5TY2h3YXJlciwgQS4gUC48L2F1dGhvcj48YXV0aG9yPkd1eSwgUy48L2F1dGhv

cj48YXV0aG9yPkJhamVsLCBBLjwvYXV0aG9yPjxhdXRob3I+VHJhbW9udGFuYSwgQS4gUi48L2F1

dGhvcj48YXV0aG9yPlNwZWxtYW4sIFQuPC9hdXRob3I+PGF1dGhvcj5TbGF2aW4sIE0uIEEuPC9h

dXRob3I+PGF1dGhvcj5BdXN0cmFsYXNpYW4gTGV1a2FlbWlhIEx5bXBob21hLCBHcm91cDwvYXV0

aG9yPjxhdXRob3I+dGhlLCBBdXN0cmFsaWE8L2F1dGhvcj48YXV0aG9yPk5ldyBaZWFsYW5kIE15

Y29sb2d5IEludGVyZXN0LCBHcm91cDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

YXV0aC1hZGRyZXNzPkluZmVjdGlvdXMgRGlzZWFzZXMgVW5pdCwgQWxmcmVkIEhlYWx0aCwgYW5k

IERlcGFydG1lbnQgb2YgSW5mZWN0aW91cyBEaXNlYXNlcywgQ2VudHJhbCBDbGluaWNhbCBTY2hv

b2wsIE1vbmFzaCBVbml2ZXJzaXR5LCBNZWxib3VybmUsIFZJQywgQXVzdHJhbGlhLiBvLm1vcnJp

c3NleUBhbGZyZWQub3JnLmF1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R2FsYWN0b21h

bm5hbiBhbmQgUENSIHZlcnN1cyBjdWx0dXJlIGFuZCBoaXN0b2xvZ3kgZm9yIGRpcmVjdGluZyB1

c2Ugb2YgYW50aWZ1bmdhbCB0cmVhdG1lbnQgZm9yIGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgaW4g

aGlnaC1yaXNrIGhhZW1hdG9sb2d5IHBhdGllbnRzOiBhIHJhbmRvbWlzZWQgY29udHJvbGxlZCB0

cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5MYW5jZXQgSW5mZWN0IERpczwvc2Vjb25kYXJ5

LXRpdGxlPjxhbHQtdGl0bGU+VGhlIExhbmNldC4gSW5mZWN0aW91cyBkaXNlYXNlczwvYWx0LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkxhbmNldCBJbmZlY3Rpb3VzIERp

c2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+TGFuY2V0IEluZmVjdC4gRGlzLjwvYWJici0xPjxh

YmJyLTI+TGFuY2V0IEluZmVjdCBEaXM8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjUxOS0y

ODwvcGFnZXM+PHZvbHVtZT4xMzwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxrZXl3b3Jkcz48

a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BbnRpZnVuZ2FsIEFnZW50cy8qdGhlcmFw

ZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvZGlhZ25vc2lzLypkcnVn

IHRoZXJhcHkvKm1ldGFib2xpc20vcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2ls

bHVzLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uL3BhdGhvZ2VuaWNpdHk8L2tleXdvcmQ+

PGtleXdvcmQ+QmlvbG9naWNhbCBNYXJrZXJzL21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+

RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3

b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5MZXVrZW1pYSwgTHltcGhvaWQvZHJ1ZyB0aGVy

YXB5LyptaWNyb2Jpb2xvZ3kvc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPk1hbm5hbnMvKm1ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFn

ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBSZWFjdGlvbi8qbWV0aG9kczwv

a2V5d29yZD48a2V5d29yZD5TdGVtIENlbGwgVHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3

b3JkPlRyYW5zcGxhbnRhdGlvbiwgSG9tb2xvZ291czwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDEzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuPC9kYXRlPjwvcHViLWRhdGVz

PjwvZGF0ZXM+PGlzYm4+MTQ3NC00NDU3IChFbGVjdHJvbmljKSYjeEQ7MTQ3My0zMDk5IChMaW5r

aW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMzYzOTYxMjwvYWNjZXNzaW9uLW51bT48dXJscz48

cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMzYz

OTYxMjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTAxNi9TMTQ3My0zMDk5KDEzKTcwMDc2LTg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [80], and was associated with an earlier diagnosis and lower incidence of IA PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BZ3VhZG88L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS

ZWNOdW0+NjkwPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls4MV08L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NjkwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9IjE0

NDU1NTU4MjUiPjY5MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QWd1

YWRvLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+VmF6cXVleiwgTC48L2F1dGhvcj48YXV0aG9yPkZl

cm5hbmRlei1SdWl6LCBNLjwvYXV0aG9yPjxhdXRob3I+VmlsbGFlc2N1c2EsIFQuPC9hdXRob3I+

PGF1dGhvcj5SdWl6LUNhbXBzLCBJLjwvYXV0aG9yPjxhdXRob3I+QmFyYmEsIFAuPC9hdXRob3I+

PGF1dGhvcj5TaWx2YSwgSi4gVC48L2F1dGhvcj48YXV0aG9yPkJhdGxsZSwgTS48L2F1dGhvcj48

YXV0aG9yPlNvbGFubywgQy48L2F1dGhvcj48YXV0aG9yPkdhbGxhcmRvLCBELjwvYXV0aG9yPjxh

dXRob3I+SGVyYXMsIEkuPC9hdXRob3I+PGF1dGhvcj5Qb2xvLCBNLjwvYXV0aG9yPjxhdXRob3I+

VmFyZWxhLCBSLjwvYXV0aG9yPjxhdXRob3I+VmFsbGVqbywgQy48L2F1dGhvcj48YXV0aG9yPk9s

YXZlLCBULjwvYXV0aG9yPjxhdXRob3I+TG9wZXotSmltZW5leiwgSi48L2F1dGhvcj48YXV0aG9y

PlJvdmlyYSwgTS48L2F1dGhvcj48YXV0aG9yPlBhcm9keSwgUi48L2F1dGhvcj48YXV0aG9yPkN1

ZW5jYS1Fc3RyZWxsYSwgTS48L2F1dGhvcj48YXV0aG9yPlBjcmFnYSBTdHVkeSBHcm91cDwvYXV0

aG9yPjxhdXRob3I+U3BhbmlzaCBTdGVtIENlbGwgVHJhbnNwbGFudGF0aW9uLCBHcm91cDwvYXV0

aG9yPjxhdXRob3I+U3R1ZHkgR3JvdXAgb2YgTWVkaWNhbCBNeWNvbG9neSBvZiB0aGUgU3Bhbmlz

aCBTb2NpZXR5IG9mIENsaW5pY2FsLCBNaWNyb2Jpb2xvZ3k8L2F1dGhvcj48YXV0aG9yPkluZmVj

dGlvdXMsIERpc2Vhc2VzPC9hdXRob3I+PGF1dGhvcj5TcGFuaXNoIE5ldHdvcmsgZm9yIFJlc2Vh

cmNoIGluIEluZmVjdGlvdXMsIERpc2Vhc2VzPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjxhdXRoLWFkZHJlc3M+VW5pdCBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzLCBIb3NwaXRhbCBV

bml2ZXJzaXRhcmlvIDEyIGRlIE9jdHVicmUsIEluc3RpdHV0byBkZSBJbnZlc3RpZ2FjaW9uIEhv

c3BpdGFsIDEyIGRlIE9jdHVicmUgKGkrMTIpLCBNYWRyaWQuJiN4RDtEZXBhcnRtZW50IG9mIEhl

bWF0b2xvZ3ksIEhvc3BpdGFsIFVuaXZlcnNpdGFyaW8gZGUgU2FsYW1hbmNhLiYjeEQ7RGVwYXJ0

bWVudCBvZiBIZW1hdG9sb2d5LCBGdW5kYWNpb24gSmltZW5leiBEaWF6LCBNYWRyaWQuJiN4RDtE

ZXBhcnRtZW50IG9mIEluZmVjdGlvdXMgRGlzZWFzZXMuJiN4RDtEZXBhcnRtZW50IG9mIEhlbWF0

b2xvZ3ksIEhvc3BpdGFsIFVuaXZlcnNpdGFyaSBWYWxsIGQmYXBvcztIZWJyb24sIEJhcmNlbG9u

YS4mI3hEO0RlcGFydG1lbnQgb2YgQ2xpbmljYWwgSGVtYXRvbG9neSwgSW5zdGl0dXQgQ2F0YWxh

IGQmYXBvcztPbmNvbG9naWEsIEhvc3BpdGFsIEdlcm1hbnMgVHJpYXMgaSBQdWpvbCwgQmFkYWxv

bmEuJiN4RDtEZXBhcnRtZW50IG9mIEhlbWF0b2xvZ3kgYW5kIE1lZGljYWwgT25jb2xvZ3ksIEhv

c3BpdGFsIENsaW5pY28gVW5pdmVyc2l0YXJpby1JTkNMSVZBLCBWYWxlbmNpYS4mI3hEO0RlcGFy

dG1lbnQgb2YgSGVtYXRvbG9neSwgSW5zdGl0dXQgQ2F0YWxhIGQmYXBvcztPbmNvbG9naWEsIEhv

c3BpdGFsIEpvc2VwIFRydWV0YSwgR2lyb25hLiYjeEQ7RGVwYXJ0bWVudCBvZiBIZW1hdG9sb2d5

LCBIb3NwaXRhbCBVbml2ZXJzaXRhcmlvIE1vcmFsZXMgTWVzZWd1ZXIsIE11cmNpYS4mI3hEO0Rl

cGFydG1lbnQgb2YgSGVtYXRvbG9neSwgSG9zcGl0YWwgQ2xpbmljbyBVbml2ZXJzaXRhcmlvIFNh

biBDYXJsb3MsIEluc3RpdHV0byBkZSBJbnZlc3RpZ2FjaW9uIFNhbml0YXJpYSBkZWwgSG9zcGl0

YWwgQ2xpbmljbyBTYW4gQ2FybG9zLCBNYWRyaWQuJiN4RDtEZXBhcnRtZW50IG9mIEhlbWF0b2xv

Z3ksIENvbXBsZXhvIEhvc3BpdGFsYXJpbyBVbml2ZXJzaXRhcmlvIEEgQ29ydW5hLiYjeEQ7RGVw

YXJ0bWVudCBvZiBIZW1hdG9sb2d5LCBIb3NwaXRhbCBVbml2ZXJzaXRhcmlvIENlbnRyYWwgZGUg

QXN0dXJpYXMsIE92aWVkby4mI3hEO0RlcGFydG1lbnQgb2YgSGVtYXRvbG9neSwgSG9zcGl0YWwg

Q2xpbmljbyBVbml2ZXJzaXRhcmlvIGRlIFphcmFnb3phLiYjeEQ7RGVwYXJ0bWVudCBvZiBIZW1h

dG9sb2d5LCBIb3NwaXRhbCBVbml2ZXJzaXRhcmlvIFJhbW9uIHkgQ2FqYWwsIE1hZHJpZC4mI3hE

O0RlcGFydG1lbnQgb2YgSGVtYXRvbG9neSwgSG9zcGl0YWwgQ2xpbmljLCBJbnN0aXR1dCBkJmFw

b3M7SW52ZXN0aWdhY2lvbnMgQmlvbWVkaXF1ZXMgQXVndXN0IFBpIGkgU3VueWVyLCBCYXJjZWxv

bmEuJiN4RDtEZXBhcnRtZW50IG9mIEhlbWF0b2xvZ3ksIEhvc3BpdGFsIFVuaXZlcnNpdGFyaW8g

VmlyZ2VuIGRlbCBSb2NpbywgSW5zdGl0dXRvIGRlIEJpb21lZGljaW5hIGRlIFNldmlsbGEuJiN4

RDtEZXBhcnRtZW50IG9mIE15Y29sb2d5LCBTcGFuaXNoIE5hdGlvbmFsIENlbnRlciBmb3IgTWlj

cm9iaW9sb2d5LCBJbnN0aXR1dG8gZGUgU2FsdWQgQ2FybG9zIElJSSwgTWFqYWRhaG9uZGEsIFNw

YWluLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlNlcnVtIGdhbGFjdG9tYW5uYW4gdmVy

c3VzIGEgY29tYmluYXRpb24gb2YgZ2FsYWN0b21hbm5hbiBhbmQgcG9seW1lcmFzZSBjaGFpbiBy

ZWFjdGlvbi1iYXNlZCBBc3BlcmdpbGx1cyBETkEgZGV0ZWN0aW9uIGZvciBlYXJseSB0aGVyYXB5

IG9mIGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgaW4gaGlnaC1yaXNrIGhlbWF0b2xvZ2ljYWwgcGF0

aWVudHM6IGEgcmFuZG9taXplZCBjb250cm9sbGVkIHRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkNsaW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFi

YnItMT5DbGluLiBJbmZlY3QuIERpcy48L2FiYnItMT48YWJici0yPkNsaW4gSW5mZWN0IERpczwv

YWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+NDA1LTE0PC9wYWdlcz48dm9sdW1lPjYwPC92b2x1

bWU+PG51bWJlcj4zPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxr

ZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzL2V0

aW9sb2d5L2dlbmV0aWNzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvZ2Vu

ZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+RE5BLCBGdW5nYWwvYmxvb2Q8L2tleXdvcmQ+PGtleXdv

cmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5MZXVr

ZW1pYSwgTXllbG9pZCwgQWN1dGUvKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFs

ZTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5zLypibG9vZDwva2V5d29yZD48a2V5d29yZD5NaWRk

bGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5NeWVsb2R5c3BsYXN0aWMgU3luZHJvbWVzLypjb21w

bGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPipSZWFsLVRpbWUgUG9seW1lcmFzZSBDaGFpbiBS

ZWFjdGlvbjwva2V5d29yZD48a2V5d29yZD5TZWNvbmRhcnkgUHJldmVudGlvbjwva2V5d29yZD48

a2V5d29yZD5QY3I8L2tleXdvcmQ+PGtleXdvcmQ+Y2xpbmljYWwgdHJpYWw8L2tleXdvcmQ+PGtl

eXdvcmQ+Z2FsYWN0b21hbm5hbjwva2V5d29yZD48a2V5d29yZD5pbnZhc2l2ZSBhc3BlcmdpbGxv

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPm1vbml0b3Jpbmc8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0

ZXM+PHllYXI+MjAxNTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAxPC9kYXRlPjwvcHViLWRh

dGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00ODM4IChM

aW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNTMzNjYyMzwvYWNjZXNzaW9uLW51bT48dXJs

cz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8y

NTMzNjYyMzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTA5My9jaWQvY2l1ODMzPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48

L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BZ3VhZG88L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS

ZWNOdW0+NjkwPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls4MV08L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NjkwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9IjE0

NDU1NTU4MjUiPjY5MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QWd1

YWRvLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+VmF6cXVleiwgTC48L2F1dGhvcj48YXV0aG9yPkZl

cm5hbmRlei1SdWl6LCBNLjwvYXV0aG9yPjxhdXRob3I+VmlsbGFlc2N1c2EsIFQuPC9hdXRob3I+

PGF1dGhvcj5SdWl6LUNhbXBzLCBJLjwvYXV0aG9yPjxhdXRob3I+QmFyYmEsIFAuPC9hdXRob3I+

PGF1dGhvcj5TaWx2YSwgSi4gVC48L2F1dGhvcj48YXV0aG9yPkJhdGxsZSwgTS48L2F1dGhvcj48

YXV0aG9yPlNvbGFubywgQy48L2F1dGhvcj48YXV0aG9yPkdhbGxhcmRvLCBELjwvYXV0aG9yPjxh

dXRob3I+SGVyYXMsIEkuPC9hdXRob3I+PGF1dGhvcj5Qb2xvLCBNLjwvYXV0aG9yPjxhdXRob3I+

VmFyZWxhLCBSLjwvYXV0aG9yPjxhdXRob3I+VmFsbGVqbywgQy48L2F1dGhvcj48YXV0aG9yPk9s

YXZlLCBULjwvYXV0aG9yPjxhdXRob3I+TG9wZXotSmltZW5leiwgSi48L2F1dGhvcj48YXV0aG9y

PlJvdmlyYSwgTS48L2F1dGhvcj48YXV0aG9yPlBhcm9keSwgUi48L2F1dGhvcj48YXV0aG9yPkN1

ZW5jYS1Fc3RyZWxsYSwgTS48L2F1dGhvcj48YXV0aG9yPlBjcmFnYSBTdHVkeSBHcm91cDwvYXV0

aG9yPjxhdXRob3I+U3BhbmlzaCBTdGVtIENlbGwgVHJhbnNwbGFudGF0aW9uLCBHcm91cDwvYXV0

aG9yPjxhdXRob3I+U3R1ZHkgR3JvdXAgb2YgTWVkaWNhbCBNeWNvbG9neSBvZiB0aGUgU3Bhbmlz

aCBTb2NpZXR5IG9mIENsaW5pY2FsLCBNaWNyb2Jpb2xvZ3k8L2F1dGhvcj48YXV0aG9yPkluZmVj

dGlvdXMsIERpc2Vhc2VzPC9hdXRob3I+PGF1dGhvcj5TcGFuaXNoIE5ldHdvcmsgZm9yIFJlc2Vh

cmNoIGluIEluZmVjdGlvdXMsIERpc2Vhc2VzPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjxhdXRoLWFkZHJlc3M+VW5pdCBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzLCBIb3NwaXRhbCBV

bml2ZXJzaXRhcmlvIDEyIGRlIE9jdHVicmUsIEluc3RpdHV0byBkZSBJbnZlc3RpZ2FjaW9uIEhv

c3BpdGFsIDEyIGRlIE9jdHVicmUgKGkrMTIpLCBNYWRyaWQuJiN4RDtEZXBhcnRtZW50IG9mIEhl

bWF0b2xvZ3ksIEhvc3BpdGFsIFVuaXZlcnNpdGFyaW8gZGUgU2FsYW1hbmNhLiYjeEQ7RGVwYXJ0

bWVudCBvZiBIZW1hdG9sb2d5LCBGdW5kYWNpb24gSmltZW5leiBEaWF6LCBNYWRyaWQuJiN4RDtE

ZXBhcnRtZW50IG9mIEluZmVjdGlvdXMgRGlzZWFzZXMuJiN4RDtEZXBhcnRtZW50IG9mIEhlbWF0

b2xvZ3ksIEhvc3BpdGFsIFVuaXZlcnNpdGFyaSBWYWxsIGQmYXBvcztIZWJyb24sIEJhcmNlbG9u

YS4mI3hEO0RlcGFydG1lbnQgb2YgQ2xpbmljYWwgSGVtYXRvbG9neSwgSW5zdGl0dXQgQ2F0YWxh

IGQmYXBvcztPbmNvbG9naWEsIEhvc3BpdGFsIEdlcm1hbnMgVHJpYXMgaSBQdWpvbCwgQmFkYWxv

bmEuJiN4RDtEZXBhcnRtZW50IG9mIEhlbWF0b2xvZ3kgYW5kIE1lZGljYWwgT25jb2xvZ3ksIEhv

c3BpdGFsIENsaW5pY28gVW5pdmVyc2l0YXJpby1JTkNMSVZBLCBWYWxlbmNpYS4mI3hEO0RlcGFy

dG1lbnQgb2YgSGVtYXRvbG9neSwgSW5zdGl0dXQgQ2F0YWxhIGQmYXBvcztPbmNvbG9naWEsIEhv

c3BpdGFsIEpvc2VwIFRydWV0YSwgR2lyb25hLiYjeEQ7RGVwYXJ0bWVudCBvZiBIZW1hdG9sb2d5

LCBIb3NwaXRhbCBVbml2ZXJzaXRhcmlvIE1vcmFsZXMgTWVzZWd1ZXIsIE11cmNpYS4mI3hEO0Rl

cGFydG1lbnQgb2YgSGVtYXRvbG9neSwgSG9zcGl0YWwgQ2xpbmljbyBVbml2ZXJzaXRhcmlvIFNh

biBDYXJsb3MsIEluc3RpdHV0byBkZSBJbnZlc3RpZ2FjaW9uIFNhbml0YXJpYSBkZWwgSG9zcGl0

YWwgQ2xpbmljbyBTYW4gQ2FybG9zLCBNYWRyaWQuJiN4RDtEZXBhcnRtZW50IG9mIEhlbWF0b2xv

Z3ksIENvbXBsZXhvIEhvc3BpdGFsYXJpbyBVbml2ZXJzaXRhcmlvIEEgQ29ydW5hLiYjeEQ7RGVw

YXJ0bWVudCBvZiBIZW1hdG9sb2d5LCBIb3NwaXRhbCBVbml2ZXJzaXRhcmlvIENlbnRyYWwgZGUg

QXN0dXJpYXMsIE92aWVkby4mI3hEO0RlcGFydG1lbnQgb2YgSGVtYXRvbG9neSwgSG9zcGl0YWwg

Q2xpbmljbyBVbml2ZXJzaXRhcmlvIGRlIFphcmFnb3phLiYjeEQ7RGVwYXJ0bWVudCBvZiBIZW1h

dG9sb2d5LCBIb3NwaXRhbCBVbml2ZXJzaXRhcmlvIFJhbW9uIHkgQ2FqYWwsIE1hZHJpZC4mI3hE

O0RlcGFydG1lbnQgb2YgSGVtYXRvbG9neSwgSG9zcGl0YWwgQ2xpbmljLCBJbnN0aXR1dCBkJmFw

b3M7SW52ZXN0aWdhY2lvbnMgQmlvbWVkaXF1ZXMgQXVndXN0IFBpIGkgU3VueWVyLCBCYXJjZWxv

bmEuJiN4RDtEZXBhcnRtZW50IG9mIEhlbWF0b2xvZ3ksIEhvc3BpdGFsIFVuaXZlcnNpdGFyaW8g

VmlyZ2VuIGRlbCBSb2NpbywgSW5zdGl0dXRvIGRlIEJpb21lZGljaW5hIGRlIFNldmlsbGEuJiN4

RDtEZXBhcnRtZW50IG9mIE15Y29sb2d5LCBTcGFuaXNoIE5hdGlvbmFsIENlbnRlciBmb3IgTWlj

cm9iaW9sb2d5LCBJbnN0aXR1dG8gZGUgU2FsdWQgQ2FybG9zIElJSSwgTWFqYWRhaG9uZGEsIFNw

YWluLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlNlcnVtIGdhbGFjdG9tYW5uYW4gdmVy

c3VzIGEgY29tYmluYXRpb24gb2YgZ2FsYWN0b21hbm5hbiBhbmQgcG9seW1lcmFzZSBjaGFpbiBy

ZWFjdGlvbi1iYXNlZCBBc3BlcmdpbGx1cyBETkEgZGV0ZWN0aW9uIGZvciBlYXJseSB0aGVyYXB5

IG9mIGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgaW4gaGlnaC1yaXNrIGhlbWF0b2xvZ2ljYWwgcGF0

aWVudHM6IGEgcmFuZG9taXplZCBjb250cm9sbGVkIHRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkNsaW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFi

YnItMT5DbGluLiBJbmZlY3QuIERpcy48L2FiYnItMT48YWJici0yPkNsaW4gSW5mZWN0IERpczwv

YWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+NDA1LTE0PC9wYWdlcz48dm9sdW1lPjYwPC92b2x1

bWU+PG51bWJlcj4zPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxr

ZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzL2V0

aW9sb2d5L2dlbmV0aWNzL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvZ2Vu

ZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+RE5BLCBGdW5nYWwvYmxvb2Q8L2tleXdvcmQ+PGtleXdv

cmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5MZXVr

ZW1pYSwgTXllbG9pZCwgQWN1dGUvKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFs

ZTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5zLypibG9vZDwva2V5d29yZD48a2V5d29yZD5NaWRk

bGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5NeWVsb2R5c3BsYXN0aWMgU3luZHJvbWVzLypjb21w

bGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPipSZWFsLVRpbWUgUG9seW1lcmFzZSBDaGFpbiBS

ZWFjdGlvbjwva2V5d29yZD48a2V5d29yZD5TZWNvbmRhcnkgUHJldmVudGlvbjwva2V5d29yZD48

a2V5d29yZD5QY3I8L2tleXdvcmQ+PGtleXdvcmQ+Y2xpbmljYWwgdHJpYWw8L2tleXdvcmQ+PGtl

eXdvcmQ+Z2FsYWN0b21hbm5hbjwva2V5d29yZD48a2V5d29yZD5pbnZhc2l2ZSBhc3BlcmdpbGxv

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPm1vbml0b3Jpbmc8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0

ZXM+PHllYXI+MjAxNTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAxPC9kYXRlPjwvcHViLWRh

dGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00ODM4IChM

aW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNTMzNjYyMzwvYWNjZXNzaW9uLW51bT48dXJs

cz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8y

NTMzNjYyMzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTA5My9jaWQvY2l1ODMzPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48

L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [81]. There have been fewer PCR studies using non-blood and non-BAL samples. In several studies, PCR is superior to culture in detecting Aspergillus spp. in sputum specimens from patients with CF and allergic or chronic pulmonary aspergillosis PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GcmFjemVrPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

UmVjTnVtPjQ4MzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bODItODZdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjQ4MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1w

PSIxNDI2NjI4NTU3Ij40ODM8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkZyYWN6ZWssIE0uIEcuPC9hdXRob3I+PGF1dGhvcj5LaXJ3YW4sIE0uIEIuPC9hdXRob3I+PGF1

dGhvcj5Nb29yZSwgQy4gQi48L2F1dGhvcj48YXV0aG9yPk1vcnJpcywgSi48L2F1dGhvcj48YXV0

aG9yPkRlbm5pbmcsIEQuIFcuPC9hdXRob3I+PGF1dGhvcj5SaWNoYXJkc29uLCBNLiBELjwvYXV0

aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkluc3RpdHV0ZSBvZiBJ

bmZsYW1tYXRpb24gYW5kIFJlcGFpciwgRWR1Y2F0aW9uIGFuZCBSZXNlYXJjaCBDZW50cmUsIE1h

bmNoZXN0ZXIgQWNhZGVtaWMgSGVhbHRoIFNjaWVuY2UgQ2VudHJlIChNQUhTQyksIFVuaXZlcnNp

dHkgb2YgTWFuY2hlc3RlciwgTWFuY2hlc3RlciwgVUs7IE15Y29sb2d5IFJlZmVyZW5jZSBDZW50

cmUsIEVkdWNhdGlvbiBhbmQgUmVzZWFyY2ggQ2VudHJlLCBVbml2ZXJzaXR5IEhvc3BpdGFsIG9m

IFNvdXRoIE1hbmNoZXN0ZXIgKFVIU00pLCBNYW5jaGVzdGVyLCBVSy48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5Wb2x1bWUgZGVwZW5kZW5jeSBmb3IgY3VsdHVyZSBvZiBmdW5naSBmcm9t

IHJlc3BpcmF0b3J5IHNlY3JldGlvbnMgYW5kIGluY3JlYXNlZCBzZW5zaXRpdml0eSBvZiBBc3Bl

cmdpbGx1cyBxdWFudGl0YXRpdmUgUENSPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk15Y29zZXM8

L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPk15Y29zZXM8L2FsdC10aXRsZT48L3RpdGxlcz48

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5NeWNvc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+TXljb3Nl

czwvYWJici0xPjxhYmJyLTI+TXljb3NlczwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+TXljb3NlczwvZnVsbC10aXRsZT48YWJici0xPk15Y29zZXM8L2Fi

YnItMT48YWJici0yPk15Y29zZXM8L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz42OS03

ODwvcGFnZXM+PHZvbHVtZT41Nzwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxrZXl3b3Jkcz48

a2V5d29yZD5Bc3BlcmdpbGxvc2lzLypkaWFnbm9zaXMvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxr

ZXl3b3JkPkFzcGVyZ2lsbHVzL2dlbmV0aWNzLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9u

PC9rZXl3b3JkPjxrZXl3b3JkPkJvZGlseSBTZWNyZXRpb25zL21pY3JvYmlvbG9neTwva2V5d29y

ZD48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkL21pY3JvYmlvbG9neTwva2V5

d29yZD48a2V5d29yZD5HcmVhdCBCcml0YWluPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5

d29yZD48a2V5d29yZD5NaWNyb2Jpb2xvZ2ljYWwgVGVjaG5pcXVlcy8qbWV0aG9kczwva2V5d29y

ZD48a2V5d29yZD5Nb2xlY3VsYXIgRGlhZ25vc3RpYyBUZWNobmlxdWVzLyptZXRob2RzPC9rZXl3

b3JkPjxrZXl3b3JkPlJlYWwtVGltZSBQb2x5bWVyYXNlIENoYWluIFJlYWN0aW9uLyptZXRob2Rz

PC9rZXl3b3JkPjxrZXl3b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwva2V5d29yZD48

a2V5d29yZD5TcGVjaW1lbiBIYW5kbGluZy8qbWV0aG9kczwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDE0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RmViPC9kYXRlPjwvcHViLWRh

dGVzPjwvZGF0ZXM+PGlzYm4+MTQzOS0wNTA3IChFbGVjdHJvbmljKSYjeEQ7MDkzMy03NDA3IChM

aW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMzc4NjU0NzwvYWNjZXNzaW9uLW51bT48dXJs

cz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8y

Mzc4NjU0NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTExMS9teWMuMTIxMDM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkJheHRlcjwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051

bT45NzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+OTc8L3JlYy1udW1iZXI+PGZvcmVpZ24t

a2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdy

MmVmZHIiIHRpbWVzdGFtcD0iMTQwNjE2MDM4MSI+OTc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVm

LXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48

YXV0aG9ycz48YXV0aG9yPkJheHRlciwgQy4gRy48L2F1dGhvcj48YXV0aG9yPkR1bm4sIEcuPC9h

dXRob3I+PGF1dGhvcj5Kb25lcywgQS4gTS48L2F1dGhvcj48YXV0aG9yPldlYmIsIEsuPC9hdXRo

b3I+PGF1dGhvcj5Hb3JlLCBSLjwvYXV0aG9yPjxhdXRob3I+UmljaGFyZHNvbiwgTS4gRC48L2F1

dGhvcj48YXV0aG9yPkRlbm5pbmcsIEQuIFcuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjxhdXRoLWFkZHJlc3M+TmF0aW9uYWwgQXNwZXJnaWxsb3NpcyBDZW50cmUsIFVuaXZlcnNp

dHkgSG9zcGl0YWwgb2YgU291dGggTWFuY2hlc3RlciwgVW5pdGVkIEtpbmdkb20uIGNhcm9saW5l

LmJheHRlckBtYW5jaGVzdGVyLmFjLnVrPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Tm92

ZWwgaW1tdW5vbG9naWMgY2xhc3NpZmljYXRpb24gb2YgYXNwZXJnaWxsb3NpcyBpbiBhZHVsdCBj

eXN0aWMgZmlicm9zaXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBBbGxlcmd5IENsaW4gSW1t

dW5vbDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+VGhlIEpvdXJuYWwgb2YgYWxsZXJneSBh

bmQgY2xpbmljYWwgaW1tdW5vbG9neTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkpvdXJuYWwgb2YgQWxsZXJneSBhbmQgQ2xpbmljYWwgSW1tdW5vbG9neTwvZnVs

bC10aXRsZT48YWJici0xPkouIEFsbGVyZ3kgQ2xpbi4gSW1tdW5vbC48L2FiYnItMT48YWJici0y

PkogQWxsZXJneSBDbGluIEltbXVub2w8L2FiYnItMj48YWJici0zPkpvdXJuYWwgb2YgQWxsZXJn

eSAmYW1wOyBDbGluaWNhbCBJbW11bm9sb2d5PC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxwYWdlcz41

NjAtNTY2IGUxMDwvcGFnZXM+PHZvbHVtZT4xMzI8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48

a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWxsZXJnZW5zL2ltbXVu

b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWJvZGllcywgRnVuZ2FsL2Jsb29kPC9rZXl3b3Jk

PjxrZXl3b3JkPkFudGlnZW5zLCBGdW5nYWwvYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+QXNw

ZXJnaWxsb3Npcy8qY2xhc3NpZmljYXRpb24vY29tcGxpY2F0aW9ucy8qaW1tdW5vbG9neS9taWNy

b2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMgZnVtaWdhdHVzLyppbW11bm9s

b2d5PC9rZXl3b3JkPjxrZXl3b3JkPkN5c3RpYyBGaWJyb3Npcy9ibG9vZC9jb21wbGljYXRpb25z

LyppbW11bm9sb2d5L21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdv

cmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub2dsb2J1bGluIEUvYmxv

b2Q8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vZ2xvYnVsaW4gRy9ibG9vZDwva2V5d29yZD48a2V5

d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvYW5hbHlzaXM8L2tleXdvcmQ+PGtl

eXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SZWFsLVRpbWUgUG9s

eW1lcmFzZSBDaGFpbiBSZWFjdGlvbjwva2V5d29yZD48a2V5d29yZD5Ta2luIFRlc3RzPC9rZXl3

b3JkPjxrZXl3b3JkPlNwdXR1bS9jaGVtaXN0cnk8L2tleXdvcmQ+PGtleXdvcmQ+WW91bmcgQWR1

bHQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMzwveWVhcj48cHViLWRhdGVz

PjxkYXRlPlNlcDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwOTctNjgyNSAoRWxl

Y3Ryb25pYykmI3hEOzAwOTEtNjc0OSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjM3

MjYyNjI8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjM3MjYyNjI8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy

bHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5qYWNpLjIwMTMuMDQuMDA3PC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5CYXh0

ZXI8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+NDg1PC9SZWNOdW0+PHJlY29yZD48

cmVjLW51bWJlcj40ODU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQy

NjYyOTYwMCI+NDg1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CYXh0

ZXIsIEMuIEcuPC9hdXRob3I+PGF1dGhvcj5SYXV0ZW1hYSwgUi48L2F1dGhvcj48YXV0aG9yPkpv

bmVzLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+V2ViYiwgQS4gSy48L2F1dGhvcj48YXV0aG9yPkJ1

bGwsIE0uPC9hdXRob3I+PGF1dGhvcj5NYWhlbnRoaXJhbGluZ2FtLCBFLjwvYXV0aG9yPjxhdXRo

b3I+RGVubmluZywgRC4gVy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt

YWRkcmVzcz5OYXRpb25hbCBBc3BlcmdpbGxvc2lzIENlbnRyZSwgVW5pdmVyc2l0eSBIb3NwaXRh

bCBvZiBTb3V0aCBNYW5jaGVzdGVyLCBNYW5jaGVzdGVyLCBVSy4gY2Fyb2xpbmUuYmF4dGVyQG1h

bmNoZXN0ZXIuYWMudWs8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnRyYXZlbm91cyBh

bnRpYmlvdGljcyByZWR1Y2UgdGhlIHByZXNlbmNlIG9mIEFzcGVyZ2lsbHVzIGluIGFkdWx0IGN5

c3RpYyBmaWJyb3NpcyBzcHV0dW08L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+VGhvcmF4PC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5UaG9yYXg8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5UaG9yYXg8L2Z1bGwtdGl0bGU+PGFiYnItMT5UaG9yYXg8L2FiYnIt

MT48YWJici0yPlRob3JheDwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+VGhvcmF4PC9mdWxsLXRpdGxlPjxhYmJyLTE+VGhvcmF4PC9hYmJyLTE+PGFiYnIt

Mj5UaG9yYXg8L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz42NTItNzwvcGFnZXM+PHZv

bHVtZT42ODwvdm9sdW1lPjxudW1iZXI+NzwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVs

dDwva2V5d29yZD48a2V5d29yZD5BbnRpLUJhY3RlcmlhbCBBZ2VudHMvKmFkbWluaXN0cmF0aW9u

ICZhbXA7IGRvc2FnZTwva2V5d29yZD48a2V5d29yZD5BbnRpYm9kaWVzLCBGdW5nYWwvYW5hbHlz

aXM8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kaWFnbm9zaXMvKmRydWcgdGhlcmFw

eS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMgZnVtaWdhdHVzL2dl

bmV0aWNzL2ltbXVub2xvZ3kvKmlzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+

PGtleXdvcmQ+Q3lzdGljIEZpYnJvc2lzL2NvbXBsaWNhdGlvbnMvKm1pY3JvYmlvbG9neS9waHlz

aW9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RE5BLCBGdW5nYWwvYW5hbHlzaXM8L2tleXdv

cmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9r

ZXl3b3JkPjxrZXl3b3JkPkZvcmNlZCBFeHBpcmF0b3J5IFZvbHVtZTwva2V5d29yZD48a2V5d29y

ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5qZWN0aW9ucywgSW50cmF2ZW5vdXM8L2tleXdv

cmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9r

ZXl3b3JkPjxrZXl3b3JkPlBzZXVkb21vbmFzIEluZmVjdGlvbnMvZGlhZ25vc2lzLypkcnVnIHRo

ZXJhcHkvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJlYWwtVGltZSBQb2x5bWVyYXNl

IENoYWluIFJlYWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlNwdXR1bS8qbWljcm9iaW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjxrZXl3b3JkPlZpdGFs

IENhcGFjaXR5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+PHB1

Yi1kYXRlcz48ZGF0ZT5KdWw8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDY4LTMy

OTYgKEVsZWN0cm9uaWMpJiN4RDswMDQwLTYzNzYgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24t

bnVtPjIzNTEzMDI4PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRw

Oi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIzNTEzMDI4PC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTM2L3Rob3JheGpubC0yMDEy

LTIwMjQxMjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB

dXRob3I+RGVubmluZzwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJlY051bT40ODc8L1JlY051

bT48cmVjb3JkPjxyZWMtbnVtYmVyPjQ4NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGlt

ZXN0YW1wPSIxNDI2ODgyODUwIj40ODc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPkRlbm5pbmcsIEQuIFcuPC9hdXRob3I+PGF1dGhvcj5QYXJrLCBTLjwvYXV0aG9yPjxh

dXRob3I+TGFzcy1GbG9ybCwgQy48L2F1dGhvcj48YXV0aG9yPkZyYWN6ZWssIE0uIEcuPC9hdXRo

b3I+PGF1dGhvcj5LaXJ3YW4sIE0uPC9hdXRob3I+PGF1dGhvcj5Hb3JlLCBSLjwvYXV0aG9yPjxh

dXRob3I+U21pdGgsIEouPC9hdXRob3I+PGF1dGhvcj5CdWVpZCwgQS48L2F1dGhvcj48YXV0aG9y

Pk1vb3JlLCBDLiBCLjwvYXV0aG9yPjxhdXRob3I+Qm93eWVyLCBQLjwvYXV0aG9yPjxhdXRob3I+

UGVybGluLCBELiBTLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPk5hdGlvbmFsIEFzcGVyZ2lsbG9zaXMgQ2VudHJlLCBVbml2ZXJzaXR5IG9mIE1hbmNoZXN0

ZXIsIE1hbmNoZXN0ZXIsIFVLLiBkZGVubmluZ0BtYW5jaGVzdGVyLmFjLnVrPC9hdXRoLWFkZHJl

c3M+PHRpdGxlcz48dGl0bGU+SGlnaC1mcmVxdWVuY3kgdHJpYXpvbGUgcmVzaXN0YW5jZSBmb3Vu

ZCBJbiBub25jdWx0dXJhYmxlIEFzcGVyZ2lsbHVzIGZ1bWlnYXR1cyBmcm9tIGx1bmdzIG9mIHBh

dGllbnRzIHdpdGggY2hyb25pYyBmdW5nYWwgZGlzZWFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5DbGluIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGlu

ZmVjdGlvdXMgZGlzZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlvbiBvZiB0aGUgSW5mZWN0

aW91cyBEaXNlYXNlcyBTb2NpZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRp

dGxlPjxhYmJyLTE+Q2xpbi4gSW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5DbGluIEluZmVj

dCBEaXM8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjExMjMtOTwvcGFnZXM+PHZvbHVtZT41

Mjwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbnRpZnVuZ2Fs

IEFnZW50cy8qcGhhcm1hY29sb2d5L3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5B

c3BlcmdpbGxvc2lzLCBBbGxlcmdpYyBCcm9uY2hvcHVsbW9uYXJ5L2RydWcgdGhlcmFweS9lcGlk

ZW1pb2xvZ3kvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzIGZ1bWln

YXR1cy8qZHJ1ZyBlZmZlY3RzL2dlbmV0aWNzL2lzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb248

L2tleXdvcmQ+PGtleXdvcmQ+QnJvbmNob2FsdmVvbGFyIExhdmFnZSBGbHVpZC9taWNyb2Jpb2xv

Z3k8L2tleXdvcmQ+PGtleXdvcmQ+Q2hyb25pYyBEaXNlYXNlPC9rZXl3b3JkPjxrZXl3b3JkPkN1

bHR1cmUgTWVkaWE8L2tleXdvcmQ+PGtleXdvcmQ+RE5BLCBGdW5nYWwvYW5hbHlzaXM8L2tleXdv

cmQ+PGtleXdvcmQ+KkRydWcgUmVzaXN0YW5jZSwgRnVuZ2FsL2dlbmV0aWNzPC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbnZhc2l2ZSBQdWxtb25hcnkgQXNwZXJn

aWxsb3Npcy9kcnVnIHRoZXJhcHkvZXBpZGVtaW9sb2d5L21pY3JvYmlvbG9neTwva2V5d29yZD48

a2V5d29yZD5MdW5nLyptaWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TXV0YXRpb248L2tl

eXdvcmQ+PGtleXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBSZWFjdGlvbjwva2V5d29yZD48a2V5d29y

ZD5QdWxtb25hcnkgQXNwZXJnaWxsb3Npcy9kcnVnIHRoZXJhcHkvKmVwaWRlbWlvbG9neS9taWNy

b2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+U3B1dHVtL21pY3JvYmlvbG9neTwva2V5d29yZD48

a2V5d29yZD5Ucmlhem9sZXMvKnBoYXJtYWNvbG9neS90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+

PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heTwv

ZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzctNjU5MSAoRWxlY3Ryb25pYykmI3hE

OzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjE0NjcwMTY8L2FjY2Vz

c2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmlo

Lmdvdi9wdWJtZWQvMjE0NjcwMTY8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+

MzEwNjI2ODwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9jaWQvY2ly

MTc5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhv

cj5CYXh0ZXI8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxSZWNOdW0+NDg2PC9SZWNOdW0+PHJl

Y29yZD48cmVjLW51bWJlcj40ODY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFt

cD0iMTQyNjYzMDA0MiI+NDg2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5CYXh0ZXIsIEMuIEcuPC9hdXRob3I+PGF1dGhvcj5Kb25lcywgQS4gTS48L2F1dGhvcj48YXV0

aG9yPldlYmIsIEsuPC9hdXRob3I+PGF1dGhvcj5EZW5uaW5nLCBELiBXLjwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlRoZSBOYXRpb25hbCBBc3BlcmdpbGxv

c2lzIENlbnRyZSwgVW5pdmVyc2l0eSBIb3NwaXRhbCBvZiBTb3V0aCBNYW5jaGVzdGVyLCBTb3V0

aG1vb3IgUm9hZCwgTWFuY2hlc3RlciBNMjM5TFQsIFVLLiBjYXJvbGluZS5iYXh0ZXJAbWFuY2hl

c3Rlci5hYy51azwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkhvbW9nZW5pc2F0aW9uIG9m

IGN5c3RpYyBmaWJyb3NpcyBzcHV0dW0gYnkgc29uaWNhdGlvbi0tYW4gZXNzZW50aWFsIHN0ZXAg

Zm9yIEFzcGVyZ2lsbHVzIFBDUjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIE1pY3JvYmlvbCBN

ZXRob2RzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFsIG9mIG1pY3JvYmlvbG9n

aWNhbCBtZXRob2RzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

Sm91cm5hbCBvZiBNaWNyb2Jpb2xvZ2ljYWwgTWV0aG9kczwvZnVsbC10aXRsZT48YWJici0xPkou

IE1pY3JvYmlvbC4gTWV0aG9kczwvYWJici0xPjxhYmJyLTI+SiBNaWNyb2Jpb2wgTWV0aG9kczwv

YWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBv

ZiBNaWNyb2Jpb2xvZ2ljYWwgTWV0aG9kczwvZnVsbC10aXRsZT48YWJici0xPkouIE1pY3JvYmlv

bC4gTWV0aG9kczwvYWJici0xPjxhYmJyLTI+SiBNaWNyb2Jpb2wgTWV0aG9kczwvYWJici0yPjwv

YWx0LXBlcmlvZGljYWw+PHBhZ2VzPjc1LTgxPC9wYWdlcz48dm9sdW1lPjg1PC92b2x1bWU+PG51

bWJlcj4xPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkFzcGVyZ2lsbHVzL2dlbmV0aWNzLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3

b3JkPjxrZXl3b3JkPkN5c3RpYyBGaWJyb3Npcy8qY29tcGxpY2F0aW9uczwva2V5d29yZD48a2V5

d29yZD5ETkEsIEZ1bmdhbC9nZW5ldGljcy9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9r

ZXl3b3JkPjxrZXl3b3JkPkROQSwgUmlib3NvbWFsL2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3Jk

Pkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NaWNyb2Jpb2xvZ2ljYWwgVGVjaG5pcXVlcy9tZXRo

b2RzPC9rZXl3b3JkPjxrZXl3b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb24vbWV0aG9kczwv

a2V5d29yZD48a2V5d29yZD5QdWxtb25hcnkgQXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzL21pY3Jv

YmlvbG9neTwva2V5d29yZD48a2V5d29yZD5STkEsIFJpYm9zb21hbCwgMThTL2dlbmV0aWNzPC9r

ZXl3b3JkPjxrZXl3b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwva2V5d29yZD48a2V5

d29yZD5Tb25pY2F0aW9uLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlNwZWNpbWVuIEhhbmRs

aW5nLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlNwdXR1bS8qbWljcm9iaW9sb2d5PC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5B

cHI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xODcyLTgzNTkgKEVsZWN0cm9uaWMp

JiN4RDswMTY3LTcwMTIgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxMjc3MzQyPC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzIxMjc3MzQyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVj

dHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2oubWltZXQuMjAxMS4wMS4wMjQ8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GcmFjemVrPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

UmVjTnVtPjQ4MzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bODItODZdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjQ4MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1w

PSIxNDI2NjI4NTU3Ij40ODM8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkZyYWN6ZWssIE0uIEcuPC9hdXRob3I+PGF1dGhvcj5LaXJ3YW4sIE0uIEIuPC9hdXRob3I+PGF1

dGhvcj5Nb29yZSwgQy4gQi48L2F1dGhvcj48YXV0aG9yPk1vcnJpcywgSi48L2F1dGhvcj48YXV0

aG9yPkRlbm5pbmcsIEQuIFcuPC9hdXRob3I+PGF1dGhvcj5SaWNoYXJkc29uLCBNLiBELjwvYXV0

aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkluc3RpdHV0ZSBvZiBJ

bmZsYW1tYXRpb24gYW5kIFJlcGFpciwgRWR1Y2F0aW9uIGFuZCBSZXNlYXJjaCBDZW50cmUsIE1h

bmNoZXN0ZXIgQWNhZGVtaWMgSGVhbHRoIFNjaWVuY2UgQ2VudHJlIChNQUhTQyksIFVuaXZlcnNp

dHkgb2YgTWFuY2hlc3RlciwgTWFuY2hlc3RlciwgVUs7IE15Y29sb2d5IFJlZmVyZW5jZSBDZW50

cmUsIEVkdWNhdGlvbiBhbmQgUmVzZWFyY2ggQ2VudHJlLCBVbml2ZXJzaXR5IEhvc3BpdGFsIG9m

IFNvdXRoIE1hbmNoZXN0ZXIgKFVIU00pLCBNYW5jaGVzdGVyLCBVSy48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5Wb2x1bWUgZGVwZW5kZW5jeSBmb3IgY3VsdHVyZSBvZiBmdW5naSBmcm9t

IHJlc3BpcmF0b3J5IHNlY3JldGlvbnMgYW5kIGluY3JlYXNlZCBzZW5zaXRpdml0eSBvZiBBc3Bl

cmdpbGx1cyBxdWFudGl0YXRpdmUgUENSPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk15Y29zZXM8

L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPk15Y29zZXM8L2FsdC10aXRsZT48L3RpdGxlcz48

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5NeWNvc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+TXljb3Nl

czwvYWJici0xPjxhYmJyLTI+TXljb3NlczwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+TXljb3NlczwvZnVsbC10aXRsZT48YWJici0xPk15Y29zZXM8L2Fi

YnItMT48YWJici0yPk15Y29zZXM8L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz42OS03

ODwvcGFnZXM+PHZvbHVtZT41Nzwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxrZXl3b3Jkcz48

a2V5d29yZD5Bc3BlcmdpbGxvc2lzLypkaWFnbm9zaXMvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxr

ZXl3b3JkPkFzcGVyZ2lsbHVzL2dlbmV0aWNzLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9u

PC9rZXl3b3JkPjxrZXl3b3JkPkJvZGlseSBTZWNyZXRpb25zL21pY3JvYmlvbG9neTwva2V5d29y

ZD48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkL21pY3JvYmlvbG9neTwva2V5

d29yZD48a2V5d29yZD5HcmVhdCBCcml0YWluPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5

d29yZD48a2V5d29yZD5NaWNyb2Jpb2xvZ2ljYWwgVGVjaG5pcXVlcy8qbWV0aG9kczwva2V5d29y

ZD48a2V5d29yZD5Nb2xlY3VsYXIgRGlhZ25vc3RpYyBUZWNobmlxdWVzLyptZXRob2RzPC9rZXl3

b3JkPjxrZXl3b3JkPlJlYWwtVGltZSBQb2x5bWVyYXNlIENoYWluIFJlYWN0aW9uLyptZXRob2Rz

PC9rZXl3b3JkPjxrZXl3b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwva2V5d29yZD48

a2V5d29yZD5TcGVjaW1lbiBIYW5kbGluZy8qbWV0aG9kczwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDE0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RmViPC9kYXRlPjwvcHViLWRh

dGVzPjwvZGF0ZXM+PGlzYm4+MTQzOS0wNTA3IChFbGVjdHJvbmljKSYjeEQ7MDkzMy03NDA3IChM

aW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMzc4NjU0NzwvYWNjZXNzaW9uLW51bT48dXJs

cz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8y

Mzc4NjU0NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTExMS9teWMuMTIxMDM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkJheHRlcjwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051

bT45NzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+OTc8L3JlYy1udW1iZXI+PGZvcmVpZ24t

a2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdy

MmVmZHIiIHRpbWVzdGFtcD0iMTQwNjE2MDM4MSI+OTc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVm

LXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48

YXV0aG9ycz48YXV0aG9yPkJheHRlciwgQy4gRy48L2F1dGhvcj48YXV0aG9yPkR1bm4sIEcuPC9h

dXRob3I+PGF1dGhvcj5Kb25lcywgQS4gTS48L2F1dGhvcj48YXV0aG9yPldlYmIsIEsuPC9hdXRo

b3I+PGF1dGhvcj5Hb3JlLCBSLjwvYXV0aG9yPjxhdXRob3I+UmljaGFyZHNvbiwgTS4gRC48L2F1

dGhvcj48YXV0aG9yPkRlbm5pbmcsIEQuIFcuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjxhdXRoLWFkZHJlc3M+TmF0aW9uYWwgQXNwZXJnaWxsb3NpcyBDZW50cmUsIFVuaXZlcnNp

dHkgSG9zcGl0YWwgb2YgU291dGggTWFuY2hlc3RlciwgVW5pdGVkIEtpbmdkb20uIGNhcm9saW5l

LmJheHRlckBtYW5jaGVzdGVyLmFjLnVrPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Tm92

ZWwgaW1tdW5vbG9naWMgY2xhc3NpZmljYXRpb24gb2YgYXNwZXJnaWxsb3NpcyBpbiBhZHVsdCBj

eXN0aWMgZmlicm9zaXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBBbGxlcmd5IENsaW4gSW1t

dW5vbDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+VGhlIEpvdXJuYWwgb2YgYWxsZXJneSBh

bmQgY2xpbmljYWwgaW1tdW5vbG9neTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkpvdXJuYWwgb2YgQWxsZXJneSBhbmQgQ2xpbmljYWwgSW1tdW5vbG9neTwvZnVs

bC10aXRsZT48YWJici0xPkouIEFsbGVyZ3kgQ2xpbi4gSW1tdW5vbC48L2FiYnItMT48YWJici0y

PkogQWxsZXJneSBDbGluIEltbXVub2w8L2FiYnItMj48YWJici0zPkpvdXJuYWwgb2YgQWxsZXJn

eSAmYW1wOyBDbGluaWNhbCBJbW11bm9sb2d5PC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxwYWdlcz41

NjAtNTY2IGUxMDwvcGFnZXM+PHZvbHVtZT4xMzI8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48

a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWxsZXJnZW5zL2ltbXVu

b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWJvZGllcywgRnVuZ2FsL2Jsb29kPC9rZXl3b3Jk

PjxrZXl3b3JkPkFudGlnZW5zLCBGdW5nYWwvYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+QXNw

ZXJnaWxsb3Npcy8qY2xhc3NpZmljYXRpb24vY29tcGxpY2F0aW9ucy8qaW1tdW5vbG9neS9taWNy

b2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMgZnVtaWdhdHVzLyppbW11bm9s

b2d5PC9rZXl3b3JkPjxrZXl3b3JkPkN5c3RpYyBGaWJyb3Npcy9ibG9vZC9jb21wbGljYXRpb25z

LyppbW11bm9sb2d5L21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdv

cmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub2dsb2J1bGluIEUvYmxv

b2Q8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vZ2xvYnVsaW4gRy9ibG9vZDwva2V5d29yZD48a2V5

d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvYW5hbHlzaXM8L2tleXdvcmQ+PGtl

eXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SZWFsLVRpbWUgUG9s

eW1lcmFzZSBDaGFpbiBSZWFjdGlvbjwva2V5d29yZD48a2V5d29yZD5Ta2luIFRlc3RzPC9rZXl3

b3JkPjxrZXl3b3JkPlNwdXR1bS9jaGVtaXN0cnk8L2tleXdvcmQ+PGtleXdvcmQ+WW91bmcgQWR1

bHQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMzwveWVhcj48cHViLWRhdGVz

PjxkYXRlPlNlcDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwOTctNjgyNSAoRWxl

Y3Ryb25pYykmI3hEOzAwOTEtNjc0OSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjM3

MjYyNjI8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjM3MjYyNjI8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy

bHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5qYWNpLjIwMTMuMDQuMDA3PC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5CYXh0

ZXI8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+NDg1PC9SZWNOdW0+PHJlY29yZD48

cmVjLW51bWJlcj40ODU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQy

NjYyOTYwMCI+NDg1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CYXh0

ZXIsIEMuIEcuPC9hdXRob3I+PGF1dGhvcj5SYXV0ZW1hYSwgUi48L2F1dGhvcj48YXV0aG9yPkpv

bmVzLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+V2ViYiwgQS4gSy48L2F1dGhvcj48YXV0aG9yPkJ1

bGwsIE0uPC9hdXRob3I+PGF1dGhvcj5NYWhlbnRoaXJhbGluZ2FtLCBFLjwvYXV0aG9yPjxhdXRo

b3I+RGVubmluZywgRC4gVy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt

YWRkcmVzcz5OYXRpb25hbCBBc3BlcmdpbGxvc2lzIENlbnRyZSwgVW5pdmVyc2l0eSBIb3NwaXRh

bCBvZiBTb3V0aCBNYW5jaGVzdGVyLCBNYW5jaGVzdGVyLCBVSy4gY2Fyb2xpbmUuYmF4dGVyQG1h

bmNoZXN0ZXIuYWMudWs8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnRyYXZlbm91cyBh

bnRpYmlvdGljcyByZWR1Y2UgdGhlIHByZXNlbmNlIG9mIEFzcGVyZ2lsbHVzIGluIGFkdWx0IGN5

c3RpYyBmaWJyb3NpcyBzcHV0dW08L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+VGhvcmF4PC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5UaG9yYXg8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5UaG9yYXg8L2Z1bGwtdGl0bGU+PGFiYnItMT5UaG9yYXg8L2FiYnIt

MT48YWJici0yPlRob3JheDwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+VGhvcmF4PC9mdWxsLXRpdGxlPjxhYmJyLTE+VGhvcmF4PC9hYmJyLTE+PGFiYnIt

Mj5UaG9yYXg8L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz42NTItNzwvcGFnZXM+PHZv

bHVtZT42ODwvdm9sdW1lPjxudW1iZXI+NzwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVs

dDwva2V5d29yZD48a2V5d29yZD5BbnRpLUJhY3RlcmlhbCBBZ2VudHMvKmFkbWluaXN0cmF0aW9u

ICZhbXA7IGRvc2FnZTwva2V5d29yZD48a2V5d29yZD5BbnRpYm9kaWVzLCBGdW5nYWwvYW5hbHlz

aXM8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kaWFnbm9zaXMvKmRydWcgdGhlcmFw

eS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMgZnVtaWdhdHVzL2dl

bmV0aWNzL2ltbXVub2xvZ3kvKmlzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+

PGtleXdvcmQ+Q3lzdGljIEZpYnJvc2lzL2NvbXBsaWNhdGlvbnMvKm1pY3JvYmlvbG9neS9waHlz

aW9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RE5BLCBGdW5nYWwvYW5hbHlzaXM8L2tleXdv

cmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9r

ZXl3b3JkPjxrZXl3b3JkPkZvcmNlZCBFeHBpcmF0b3J5IFZvbHVtZTwva2V5d29yZD48a2V5d29y

ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5qZWN0aW9ucywgSW50cmF2ZW5vdXM8L2tleXdv

cmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9r

ZXl3b3JkPjxrZXl3b3JkPlBzZXVkb21vbmFzIEluZmVjdGlvbnMvZGlhZ25vc2lzLypkcnVnIHRo

ZXJhcHkvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJlYWwtVGltZSBQb2x5bWVyYXNl

IENoYWluIFJlYWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlNwdXR1bS8qbWljcm9iaW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjxrZXl3b3JkPlZpdGFs

IENhcGFjaXR5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+PHB1

Yi1kYXRlcz48ZGF0ZT5KdWw8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDY4LTMy

OTYgKEVsZWN0cm9uaWMpJiN4RDswMDQwLTYzNzYgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24t

bnVtPjIzNTEzMDI4PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRw

Oi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIzNTEzMDI4PC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTM2L3Rob3JheGpubC0yMDEy

LTIwMjQxMjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB

dXRob3I+RGVubmluZzwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJlY051bT40ODc8L1JlY051

bT48cmVjb3JkPjxyZWMtbnVtYmVyPjQ4NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGlt

ZXN0YW1wPSIxNDI2ODgyODUwIj40ODc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPkRlbm5pbmcsIEQuIFcuPC9hdXRob3I+PGF1dGhvcj5QYXJrLCBTLjwvYXV0aG9yPjxh

dXRob3I+TGFzcy1GbG9ybCwgQy48L2F1dGhvcj48YXV0aG9yPkZyYWN6ZWssIE0uIEcuPC9hdXRo

b3I+PGF1dGhvcj5LaXJ3YW4sIE0uPC9hdXRob3I+PGF1dGhvcj5Hb3JlLCBSLjwvYXV0aG9yPjxh

dXRob3I+U21pdGgsIEouPC9hdXRob3I+PGF1dGhvcj5CdWVpZCwgQS48L2F1dGhvcj48YXV0aG9y

Pk1vb3JlLCBDLiBCLjwvYXV0aG9yPjxhdXRob3I+Qm93eWVyLCBQLjwvYXV0aG9yPjxhdXRob3I+

UGVybGluLCBELiBTLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPk5hdGlvbmFsIEFzcGVyZ2lsbG9zaXMgQ2VudHJlLCBVbml2ZXJzaXR5IG9mIE1hbmNoZXN0

ZXIsIE1hbmNoZXN0ZXIsIFVLLiBkZGVubmluZ0BtYW5jaGVzdGVyLmFjLnVrPC9hdXRoLWFkZHJl

c3M+PHRpdGxlcz48dGl0bGU+SGlnaC1mcmVxdWVuY3kgdHJpYXpvbGUgcmVzaXN0YW5jZSBmb3Vu

ZCBJbiBub25jdWx0dXJhYmxlIEFzcGVyZ2lsbHVzIGZ1bWlnYXR1cyBmcm9tIGx1bmdzIG9mIHBh

dGllbnRzIHdpdGggY2hyb25pYyBmdW5nYWwgZGlzZWFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5DbGluIEluZmVjdCBEaXM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGlu

ZmVjdGlvdXMgZGlzZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlvbiBvZiB0aGUgSW5mZWN0

aW91cyBEaXNlYXNlcyBTb2NpZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRp

dGxlPjxhYmJyLTE+Q2xpbi4gSW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5DbGluIEluZmVj

dCBEaXM8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjExMjMtOTwvcGFnZXM+PHZvbHVtZT41

Mjwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbnRpZnVuZ2Fs

IEFnZW50cy8qcGhhcm1hY29sb2d5L3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5B

c3BlcmdpbGxvc2lzLCBBbGxlcmdpYyBCcm9uY2hvcHVsbW9uYXJ5L2RydWcgdGhlcmFweS9lcGlk

ZW1pb2xvZ3kvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzIGZ1bWln

YXR1cy8qZHJ1ZyBlZmZlY3RzL2dlbmV0aWNzL2lzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb248

L2tleXdvcmQ+PGtleXdvcmQ+QnJvbmNob2FsdmVvbGFyIExhdmFnZSBGbHVpZC9taWNyb2Jpb2xv

Z3k8L2tleXdvcmQ+PGtleXdvcmQ+Q2hyb25pYyBEaXNlYXNlPC9rZXl3b3JkPjxrZXl3b3JkPkN1

bHR1cmUgTWVkaWE8L2tleXdvcmQ+PGtleXdvcmQ+RE5BLCBGdW5nYWwvYW5hbHlzaXM8L2tleXdv

cmQ+PGtleXdvcmQ+KkRydWcgUmVzaXN0YW5jZSwgRnVuZ2FsL2dlbmV0aWNzPC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbnZhc2l2ZSBQdWxtb25hcnkgQXNwZXJn

aWxsb3Npcy9kcnVnIHRoZXJhcHkvZXBpZGVtaW9sb2d5L21pY3JvYmlvbG9neTwva2V5d29yZD48

a2V5d29yZD5MdW5nLyptaWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TXV0YXRpb248L2tl

eXdvcmQ+PGtleXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBSZWFjdGlvbjwva2V5d29yZD48a2V5d29y

ZD5QdWxtb25hcnkgQXNwZXJnaWxsb3Npcy9kcnVnIHRoZXJhcHkvKmVwaWRlbWlvbG9neS9taWNy

b2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+U3B1dHVtL21pY3JvYmlvbG9neTwva2V5d29yZD48

a2V5d29yZD5Ucmlhem9sZXMvKnBoYXJtYWNvbG9neS90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+

PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heTwv

ZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzctNjU5MSAoRWxlY3Ryb25pYykmI3hE

OzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjE0NjcwMTY8L2FjY2Vz

c2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmlo

Lmdvdi9wdWJtZWQvMjE0NjcwMTY8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+

MzEwNjI2ODwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9jaWQvY2ly

MTc5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhv

cj5CYXh0ZXI8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxSZWNOdW0+NDg2PC9SZWNOdW0+PHJl

Y29yZD48cmVjLW51bWJlcj40ODY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFt

cD0iMTQyNjYzMDA0MiI+NDg2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5CYXh0ZXIsIEMuIEcuPC9hdXRob3I+PGF1dGhvcj5Kb25lcywgQS4gTS48L2F1dGhvcj48YXV0

aG9yPldlYmIsIEsuPC9hdXRob3I+PGF1dGhvcj5EZW5uaW5nLCBELiBXLjwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlRoZSBOYXRpb25hbCBBc3BlcmdpbGxv

c2lzIENlbnRyZSwgVW5pdmVyc2l0eSBIb3NwaXRhbCBvZiBTb3V0aCBNYW5jaGVzdGVyLCBTb3V0

aG1vb3IgUm9hZCwgTWFuY2hlc3RlciBNMjM5TFQsIFVLLiBjYXJvbGluZS5iYXh0ZXJAbWFuY2hl

c3Rlci5hYy51azwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkhvbW9nZW5pc2F0aW9uIG9m

IGN5c3RpYyBmaWJyb3NpcyBzcHV0dW0gYnkgc29uaWNhdGlvbi0tYW4gZXNzZW50aWFsIHN0ZXAg

Zm9yIEFzcGVyZ2lsbHVzIFBDUjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIE1pY3JvYmlvbCBN

ZXRob2RzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFsIG9mIG1pY3JvYmlvbG9n

aWNhbCBtZXRob2RzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

Sm91cm5hbCBvZiBNaWNyb2Jpb2xvZ2ljYWwgTWV0aG9kczwvZnVsbC10aXRsZT48YWJici0xPkou

IE1pY3JvYmlvbC4gTWV0aG9kczwvYWJici0xPjxhYmJyLTI+SiBNaWNyb2Jpb2wgTWV0aG9kczwv

YWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBv

ZiBNaWNyb2Jpb2xvZ2ljYWwgTWV0aG9kczwvZnVsbC10aXRsZT48YWJici0xPkouIE1pY3JvYmlv

bC4gTWV0aG9kczwvYWJici0xPjxhYmJyLTI+SiBNaWNyb2Jpb2wgTWV0aG9kczwvYWJici0yPjwv

YWx0LXBlcmlvZGljYWw+PHBhZ2VzPjc1LTgxPC9wYWdlcz48dm9sdW1lPjg1PC92b2x1bWU+PG51

bWJlcj4xPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkFzcGVyZ2lsbHVzL2dlbmV0aWNzLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3

b3JkPjxrZXl3b3JkPkN5c3RpYyBGaWJyb3Npcy8qY29tcGxpY2F0aW9uczwva2V5d29yZD48a2V5

d29yZD5ETkEsIEZ1bmdhbC9nZW5ldGljcy9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9r

ZXl3b3JkPjxrZXl3b3JkPkROQSwgUmlib3NvbWFsL2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3Jk

Pkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NaWNyb2Jpb2xvZ2ljYWwgVGVjaG5pcXVlcy9tZXRo

b2RzPC9rZXl3b3JkPjxrZXl3b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb24vbWV0aG9kczwv

a2V5d29yZD48a2V5d29yZD5QdWxtb25hcnkgQXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzL21pY3Jv

YmlvbG9neTwva2V5d29yZD48a2V5d29yZD5STkEsIFJpYm9zb21hbCwgMThTL2dlbmV0aWNzPC9r

ZXl3b3JkPjxrZXl3b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwva2V5d29yZD48a2V5

d29yZD5Tb25pY2F0aW9uLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlNwZWNpbWVuIEhhbmRs

aW5nLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlNwdXR1bS8qbWljcm9iaW9sb2d5PC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5B

cHI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xODcyLTgzNTkgKEVsZWN0cm9uaWMp

JiN4RDswMTY3LTcwMTIgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxMjc3MzQyPC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzIxMjc3MzQyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVj

dHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2oubWltZXQuMjAxMS4wMS4wMjQ8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA [82-86]. Small studies of Aspergillus PCR on non-blood and extra-pulmonary body fluids (pleural fluid, CSF, etc.) and paraffin-preserved and fresh tissues (lung, skin, sinus, lymph node) demonstrate sensitivity of 86% and specificity of 100% PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWlud2FsZDwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+

PFJlY051bT4xOTI8L1JlY051bT48RGlzcGxheVRleHQ+Wzg3LTg5XTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4xOTI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFt

cD0iMTQxMzU2Mzk0MSI+MTkyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5SZWlud2FsZCwgTS48L2F1dGhvcj48YXV0aG9yPkJ1Y2hoZWlkdCwgRC48L2F1dGhvcj48YXV0

aG9yPkh1bW1lbCwgTS48L2F1dGhvcj48YXV0aG9yPkR1ZXJrZW4sIE0uPC9hdXRob3I+PGF1dGhv

cj5CZXJ0eiwgSC48L2F1dGhvcj48YXV0aG9yPlNjaHdlcmR0ZmVnZXIsIFIuPC9hdXRob3I+PGF1

dGhvcj5SZXV0ZXIsIFMuPC9hdXRob3I+PGF1dGhvcj5LaWVobCwgTS4gRy48L2F1dGhvcj48YXV0

aG9yPkJhcnJldG8tTWlyYW5kYSwgTS48L2F1dGhvcj48YXV0aG9yPkhvZm1hbm4sIFcuIEsuPC9h

dXRob3I+PGF1dGhvcj5TcGllc3MsIEIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBIZW1hdG9sb2d5IGFuZCBPbmNvbG9neSwgTWFu

bmhlaW0gVW5pdmVyc2l0eSBIb3NwaXRhbCwgVW5pdmVyc2l0eSBvZiBIZWlkZWxiZXJnLCBNYW5u

aGVpbSwgR2VybWFueS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EaWFnbm9zdGljIHBl

cmZvcm1hbmNlIG9mIGFuIEFzcGVyZ2lsbHVzLXNwZWNpZmljIG5lc3RlZCBQQ1IgYXNzYXkgaW4g

Y2VyZWJyb3NwaW5hbCBmbHVpZCBzYW1wbGVzIG9mIGltbXVub2NvbXByb21pc2VkIHBhdGllbnRz

IGZvciBkZXRlY3Rpb24gb2YgY2VudHJhbCBuZXJ2b3VzIHN5c3RlbSBhc3BlcmdpbGxvc2lzPC90

aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlBMb1MgT25lPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRs

ZT5QbG9TIG9uZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlBs

b1MgT25lPC9mdWxsLXRpdGxlPjxhYmJyLTE+UExvUyBPbmU8L2FiYnItMT48YWJici0yPlBMb1Mg

T25lPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QbG9T

IE9uZTwvZnVsbC10aXRsZT48YWJici0xPlBMb1MgT25lPC9hYmJyLTE+PGFiYnItMj5QTG9TIE9u

ZTwvYWJici0yPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPmU1NjcwNjwvcGFnZXM+PHZvbHVtZT44

PC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFzcGVyZ2lsbG9z

aXMvKmRpYWdub3Npczwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy9nZW5ldGljcy8qcGF0

aG9nZW5pY2l0eTwva2V5d29yZD48a2V5d29yZD5DZW50cmFsIE5lcnZvdXMgU3lzdGVtIERpc2Vh

c2VzPC9rZXl3b3JkPjxrZXl3b3JkPkNlcmVicm9zcGluYWwgRmx1aWQvKm1ldGFib2xpc208L2tl

eXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48

a2V5d29yZD5JbW11bm9jb21wcm9taXNlZCBIb3N0PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tl

eXdvcmQ+PGtleXdvcmQ+TmV1cm9hc3BlcmdpbGxvc2lzLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtl

eXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBSZWFjdGlvbi8qbWV0aG9kczwva2V5d29yZD48L2tleXdv

cmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTkzMi02MjAzIChFbGVj

dHJvbmljKSYjeEQ7MTkzMi02MjAzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMzQ1

MTA3MTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5u

Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMzQ1MTA3MTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48Y3VzdG9tMj4zNTc5ODI2PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4x

MzcxL2pvdXJuYWwucG9uZS4wMDU2NzA2PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29y

ZD48L0NpdGU+PENpdGU+PEF1dGhvcj5SZWlud2FsZDwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+

PFJlY051bT44MDg8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjgwODwvcmVjLW51bWJlcj48

Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFw

c3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDU0MzcxMDk2Ij44MDg8L2tleT48L2ZvcmVpZ24t

a2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRy

aWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlJlaW53YWxkLCBNLjwvYXV0aG9yPjxhdXRob3I+U3Bp

ZXNzLCBCLjwvYXV0aG9yPjxhdXRob3I+SGVpbnosIFcuIEouPC9hdXRob3I+PGF1dGhvcj5IZXVz

c2VsLCBDLiBQLjwvYXV0aG9yPjxhdXRob3I+QmVydHosIEguPC9hdXRob3I+PGF1dGhvcj5Db3Ju

ZWx5LCBPLiBBLjwvYXV0aG9yPjxhdXRob3I+SGFobiwgSi48L2F1dGhvcj48YXV0aG9yPkxlaHJu

YmVjaGVyLCBULjwvYXV0aG9yPjxhdXRob3I+S2llaGwsIE0uPC9hdXRob3I+PGF1dGhvcj5MYXdz

LCBILiBKLjwvYXV0aG9yPjxhdXRob3I+V29sZiwgSC4gSC48L2F1dGhvcj48YXV0aG9yPlNjaHdl

cmR0ZmVnZXIsIFIuPC9hdXRob3I+PGF1dGhvcj5TY2h1bHRoZWlzLCBCLjwvYXV0aG9yPjxhdXRo

b3I+QnVyY2hhcmR0LCBBLjwvYXV0aG9yPjxhdXRob3I+S2xlaW4sIE0uPC9hdXRob3I+PGF1dGhv

cj5EdXJrZW4sIE0uPC9hdXRob3I+PGF1dGhvcj5DbGF1cywgQi48L2F1dGhvcj48YXV0aG9yPlNj

aGxlZ2VsLCBGLjwvYXV0aG9yPjxhdXRob3I+SHVtbWVsLCBNLjwvYXV0aG9yPjxhdXRob3I+SG9m

bWFubiwgVy4gSy48L2F1dGhvcj48YXV0aG9yPkJ1Y2hoZWlkdCwgRC48L2F1dGhvcj48L2F1dGhv

cnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NYW5uaGVpbSBVbml2ZXJzaXR5IEhvc3Bp

dGFsLCBVbml2ZXJzaXR5IG9mIEhlaWRlbGJlcmcsIEhlaWRlbGJlcmcsIEdlcm1hbnkuPC9hdXRo

LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QXNwZXJnaWxsdXMgUENSLWJhc2VkIGludmVzdGlnYXRp

b24gb2YgZnJlc2ggdGlzc3VlIGFuZCBlZmZ1c2lvbiBzYW1wbGVzIGluIHBhdGllbnRzIHdpdGgg

c3VzcGVjdGVkIGludmFzaXZlIEFzcGVyZ2lsbG9zaXMgZW5oYW5jZXMgZGlhZ25vc3RpYyBjYXBh

YmlsaXRpZXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBDbGluIE1pY3JvYmlvbDwvc2Vjb25k

YXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xp

bmljYWwgTWljcm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQ2xpbi4gTWljcm9iaW9s

LjwvYWJici0xPjxhYmJyLTI+SiBDbGluIE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48

cGFnZXM+NDE3OC04NTwvcGFnZXM+PHZvbHVtZT41MTwvdm9sdW1lPjxudW1iZXI+MTI8L251bWJl

cj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwv

a2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVy

PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvKmRpYWdub3Npczwva2V5d29yZD48a2V5

d29yZD5Bc3BlcmdpbGx1cy9nZW5ldGljcy8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwv

a2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5DaGlsZCwgUHJlc2Nob29s

PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdv

cmQ+PGtleXdvcmQ+THVuZy9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5

d29yZD48a2V5d29yZD5NaWNyb2Jpb2xvZ2ljYWwgVGVjaG5pcXVlcy8qbWV0aG9kczwva2V5d29y

ZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Nb2xlY3VsYXIgRGlhZ25v

c3RpYyBUZWNobmlxdWVzLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlBsZXVyYWwgRWZmdXNp

b24vbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rp

b24vKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3

b3JkPjxrZXl3b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwva2V5d29yZD48a2V5d29y

ZD5Zb3VuZyBBZHVsdDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+RGVjPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA5

OC02NjBYIChFbGVjdHJvbmljKSYjeEQ7MDA5NS0xMTM3IChMaW5raW5nKTwvaXNibj48YWNjZXNz

aW9uLW51bT4yNDEwODYxMjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yNDEwODYxMjwvdXJsPjwvcmVsYXRl

ZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMzODM4MDQ4PC9jdXN0b20yPjxlbGVjdHJvbmljLXJl

c291cmNlLW51bT4xMC4xMTI4L0pDTS4wMjM4Ny0xMzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QnVpdHJhZ288L0F1dGhvcj48WWVhcj4yMDEz

PC9ZZWFyPjxSZWNOdW0+ODA5PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj44MDk8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVy

dDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM3MTc1NCI+ODA5PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CdWl0cmFnbywgTS4gSi48L2F1dGhvcj48

YXV0aG9yPkFndWFkbywgSi4gTS48L2F1dGhvcj48YXV0aG9yPkJhbGxlbiwgQS48L2F1dGhvcj48

YXV0aG9yPkJlcm5hbC1NYXJ0aW5leiwgTC48L2F1dGhvcj48YXV0aG9yPlByaWV0bywgTS48L2F1

dGhvcj48YXV0aG9yPkdhcmNpYS1SZXluZSwgQS48L2F1dGhvcj48YXV0aG9yPkdhcmNpYS1Sb2Ry

aWd1ZXosIEouPC9hdXRob3I+PGF1dGhvcj5Sb2RyaWd1ZXotVHVkZWxhLCBKLiBMLjwvYXV0aG9y

PjxhdXRob3I+Q3VlbmNhLUVzdHJlbGxhLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPkluc3RpdHV0byBkZSBTYWx1ZCBDYXJsb3MgSUlJLCBNYWphZGFo

b25kYSwgU3BhaW4uPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZmaWNhY3kgb2YgRE5B

IGFtcGxpZmljYXRpb24gaW4gdGlzc3VlIGJpb3BzeSBzYW1wbGVzIHRvIGltcHJvdmUgdGhlIGRl

dGVjdGlvbiBvZiBpbnZhc2l2ZSBmdW5nYWwgZGlzZWFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5DbGluIE1pY3JvYmlvbCBJbmZlY3Q8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5DbGluaWNhbCBNaWNyb2Jpb2xvZ3kgYW5kIEluZmVjdGlvbjwvZnVs

bC10aXRsZT48YWJici0xPkNsaW4uIE1pY3JvYmlvbC4gSW5mZWN0LjwvYWJici0xPjxhYmJyLTI+

Q2xpbiBNaWNyb2Jpb2wgSW5mZWN0PC9hYmJyLTI+PGFiYnItMz5DbGluaWNhbCBNaWNyb2Jpb2xv

Z3kgJmFtcDsgSW5mZWN0aW9uPC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxwYWdlcz5FMjcxLTc8L3Bh

Z2VzPjx2b2x1bWU+MTk8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48a2V5d29yZHM+PGtleXdv

cmQ+QmlvcHN5PC9rZXl3b3JkPjxrZXl3b3JkPipETkEsIEZ1bmdhbDwva2V5d29yZD48a2V5d29y

ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TXljb3Nlcy8qZGlhZ25vc2lzL21pY3JvYmlvbG9n

eTwva2V5d29yZD48a2V5d29yZD4qTnVjbGVpYyBBY2lkIEFtcGxpZmljYXRpb24gVGVjaG5pcXVl

cy9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlJlYWwtVGltZSBQb2x5bWVyYXNlIENoYWluIFJl

YWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlJlcHJvZHVjaWJpbGl0eSBvZiBSZXN1bHRzPC9rZXl3

b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5TZW5z

aXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAxMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVz

Pjxpc2JuPjE0NjktMDY5MSAoRWxlY3Ryb25pYykmI3hEOzExOTgtNzQzWCAoTGlua2luZyk8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+MjM0NjQ3NTE8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQt

dXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjM0NjQ3NTE8L3Vy

bD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMTEv

MTQ2OS0wNjkxLjEyMTEwPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+

PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWlud2FsZDwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+

PFJlY051bT4xOTI8L1JlY051bT48RGlzcGxheVRleHQ+Wzg3LTg5XTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4xOTI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFt

cD0iMTQxMzU2Mzk0MSI+MTkyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5SZWlud2FsZCwgTS48L2F1dGhvcj48YXV0aG9yPkJ1Y2hoZWlkdCwgRC48L2F1dGhvcj48YXV0

aG9yPkh1bW1lbCwgTS48L2F1dGhvcj48YXV0aG9yPkR1ZXJrZW4sIE0uPC9hdXRob3I+PGF1dGhv

cj5CZXJ0eiwgSC48L2F1dGhvcj48YXV0aG9yPlNjaHdlcmR0ZmVnZXIsIFIuPC9hdXRob3I+PGF1

dGhvcj5SZXV0ZXIsIFMuPC9hdXRob3I+PGF1dGhvcj5LaWVobCwgTS4gRy48L2F1dGhvcj48YXV0

aG9yPkJhcnJldG8tTWlyYW5kYSwgTS48L2F1dGhvcj48YXV0aG9yPkhvZm1hbm4sIFcuIEsuPC9h

dXRob3I+PGF1dGhvcj5TcGllc3MsIEIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBIZW1hdG9sb2d5IGFuZCBPbmNvbG9neSwgTWFu

bmhlaW0gVW5pdmVyc2l0eSBIb3NwaXRhbCwgVW5pdmVyc2l0eSBvZiBIZWlkZWxiZXJnLCBNYW5u

aGVpbSwgR2VybWFueS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EaWFnbm9zdGljIHBl

cmZvcm1hbmNlIG9mIGFuIEFzcGVyZ2lsbHVzLXNwZWNpZmljIG5lc3RlZCBQQ1IgYXNzYXkgaW4g

Y2VyZWJyb3NwaW5hbCBmbHVpZCBzYW1wbGVzIG9mIGltbXVub2NvbXByb21pc2VkIHBhdGllbnRz

IGZvciBkZXRlY3Rpb24gb2YgY2VudHJhbCBuZXJ2b3VzIHN5c3RlbSBhc3BlcmdpbGxvc2lzPC90

aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlBMb1MgT25lPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRs

ZT5QbG9TIG9uZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlBs

b1MgT25lPC9mdWxsLXRpdGxlPjxhYmJyLTE+UExvUyBPbmU8L2FiYnItMT48YWJici0yPlBMb1Mg

T25lPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QbG9T

IE9uZTwvZnVsbC10aXRsZT48YWJici0xPlBMb1MgT25lPC9hYmJyLTE+PGFiYnItMj5QTG9TIE9u

ZTwvYWJici0yPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPmU1NjcwNjwvcGFnZXM+PHZvbHVtZT44

PC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFzcGVyZ2lsbG9z

aXMvKmRpYWdub3Npczwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy9nZW5ldGljcy8qcGF0

aG9nZW5pY2l0eTwva2V5d29yZD48a2V5d29yZD5DZW50cmFsIE5lcnZvdXMgU3lzdGVtIERpc2Vh

c2VzPC9rZXl3b3JkPjxrZXl3b3JkPkNlcmVicm9zcGluYWwgRmx1aWQvKm1ldGFib2xpc208L2tl

eXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48

a2V5d29yZD5JbW11bm9jb21wcm9taXNlZCBIb3N0PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tl

eXdvcmQ+PGtleXdvcmQ+TmV1cm9hc3BlcmdpbGxvc2lzLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtl

eXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBSZWFjdGlvbi8qbWV0aG9kczwva2V5d29yZD48L2tleXdv

cmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTkzMi02MjAzIChFbGVj

dHJvbmljKSYjeEQ7MTkzMi02MjAzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMzQ1

MTA3MTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5u

Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMzQ1MTA3MTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48Y3VzdG9tMj4zNTc5ODI2PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4x

MzcxL2pvdXJuYWwucG9uZS4wMDU2NzA2PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29y

ZD48L0NpdGU+PENpdGU+PEF1dGhvcj5SZWlud2FsZDwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+

PFJlY051bT44MDg8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjgwODwvcmVjLW51bWJlcj48

Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFw

c3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDU0MzcxMDk2Ij44MDg8L2tleT48L2ZvcmVpZ24t

a2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRy

aWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlJlaW53YWxkLCBNLjwvYXV0aG9yPjxhdXRob3I+U3Bp

ZXNzLCBCLjwvYXV0aG9yPjxhdXRob3I+SGVpbnosIFcuIEouPC9hdXRob3I+PGF1dGhvcj5IZXVz

c2VsLCBDLiBQLjwvYXV0aG9yPjxhdXRob3I+QmVydHosIEguPC9hdXRob3I+PGF1dGhvcj5Db3Ju

ZWx5LCBPLiBBLjwvYXV0aG9yPjxhdXRob3I+SGFobiwgSi48L2F1dGhvcj48YXV0aG9yPkxlaHJu

YmVjaGVyLCBULjwvYXV0aG9yPjxhdXRob3I+S2llaGwsIE0uPC9hdXRob3I+PGF1dGhvcj5MYXdz

LCBILiBKLjwvYXV0aG9yPjxhdXRob3I+V29sZiwgSC4gSC48L2F1dGhvcj48YXV0aG9yPlNjaHdl

cmR0ZmVnZXIsIFIuPC9hdXRob3I+PGF1dGhvcj5TY2h1bHRoZWlzLCBCLjwvYXV0aG9yPjxhdXRo

b3I+QnVyY2hhcmR0LCBBLjwvYXV0aG9yPjxhdXRob3I+S2xlaW4sIE0uPC9hdXRob3I+PGF1dGhv

cj5EdXJrZW4sIE0uPC9hdXRob3I+PGF1dGhvcj5DbGF1cywgQi48L2F1dGhvcj48YXV0aG9yPlNj

aGxlZ2VsLCBGLjwvYXV0aG9yPjxhdXRob3I+SHVtbWVsLCBNLjwvYXV0aG9yPjxhdXRob3I+SG9m

bWFubiwgVy4gSy48L2F1dGhvcj48YXV0aG9yPkJ1Y2hoZWlkdCwgRC48L2F1dGhvcj48L2F1dGhv

cnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NYW5uaGVpbSBVbml2ZXJzaXR5IEhvc3Bp

dGFsLCBVbml2ZXJzaXR5IG9mIEhlaWRlbGJlcmcsIEhlaWRlbGJlcmcsIEdlcm1hbnkuPC9hdXRo

LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QXNwZXJnaWxsdXMgUENSLWJhc2VkIGludmVzdGlnYXRp

b24gb2YgZnJlc2ggdGlzc3VlIGFuZCBlZmZ1c2lvbiBzYW1wbGVzIGluIHBhdGllbnRzIHdpdGgg

c3VzcGVjdGVkIGludmFzaXZlIEFzcGVyZ2lsbG9zaXMgZW5oYW5jZXMgZGlhZ25vc3RpYyBjYXBh

YmlsaXRpZXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBDbGluIE1pY3JvYmlvbDwvc2Vjb25k

YXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xp

bmljYWwgTWljcm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQ2xpbi4gTWljcm9iaW9s

LjwvYWJici0xPjxhYmJyLTI+SiBDbGluIE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48

cGFnZXM+NDE3OC04NTwvcGFnZXM+PHZvbHVtZT41MTwvdm9sdW1lPjxudW1iZXI+MTI8L251bWJl

cj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwv

a2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVy

PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvKmRpYWdub3Npczwva2V5d29yZD48a2V5

d29yZD5Bc3BlcmdpbGx1cy9nZW5ldGljcy8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwv

a2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5DaGlsZCwgUHJlc2Nob29s

PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdv

cmQ+PGtleXdvcmQ+THVuZy9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5

d29yZD48a2V5d29yZD5NaWNyb2Jpb2xvZ2ljYWwgVGVjaG5pcXVlcy8qbWV0aG9kczwva2V5d29y

ZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Nb2xlY3VsYXIgRGlhZ25v

c3RpYyBUZWNobmlxdWVzLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlBsZXVyYWwgRWZmdXNp

b24vbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rp

b24vKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3

b3JkPjxrZXl3b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwva2V5d29yZD48a2V5d29y

ZD5Zb3VuZyBBZHVsdDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+RGVjPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA5

OC02NjBYIChFbGVjdHJvbmljKSYjeEQ7MDA5NS0xMTM3IChMaW5raW5nKTwvaXNibj48YWNjZXNz

aW9uLW51bT4yNDEwODYxMjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yNDEwODYxMjwvdXJsPjwvcmVsYXRl

ZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMzODM4MDQ4PC9jdXN0b20yPjxlbGVjdHJvbmljLXJl

c291cmNlLW51bT4xMC4xMTI4L0pDTS4wMjM4Ny0xMzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QnVpdHJhZ288L0F1dGhvcj48WWVhcj4yMDEz

PC9ZZWFyPjxSZWNOdW0+ODA5PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj44MDk8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVy

dDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM3MTc1NCI+ODA5PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CdWl0cmFnbywgTS4gSi48L2F1dGhvcj48

YXV0aG9yPkFndWFkbywgSi4gTS48L2F1dGhvcj48YXV0aG9yPkJhbGxlbiwgQS48L2F1dGhvcj48

YXV0aG9yPkJlcm5hbC1NYXJ0aW5leiwgTC48L2F1dGhvcj48YXV0aG9yPlByaWV0bywgTS48L2F1

dGhvcj48YXV0aG9yPkdhcmNpYS1SZXluZSwgQS48L2F1dGhvcj48YXV0aG9yPkdhcmNpYS1Sb2Ry

aWd1ZXosIEouPC9hdXRob3I+PGF1dGhvcj5Sb2RyaWd1ZXotVHVkZWxhLCBKLiBMLjwvYXV0aG9y

PjxhdXRob3I+Q3VlbmNhLUVzdHJlbGxhLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPkluc3RpdHV0byBkZSBTYWx1ZCBDYXJsb3MgSUlJLCBNYWphZGFo

b25kYSwgU3BhaW4uPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZmaWNhY3kgb2YgRE5B

IGFtcGxpZmljYXRpb24gaW4gdGlzc3VlIGJpb3BzeSBzYW1wbGVzIHRvIGltcHJvdmUgdGhlIGRl

dGVjdGlvbiBvZiBpbnZhc2l2ZSBmdW5nYWwgZGlzZWFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5DbGluIE1pY3JvYmlvbCBJbmZlY3Q8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5DbGluaWNhbCBNaWNyb2Jpb2xvZ3kgYW5kIEluZmVjdGlvbjwvZnVs

bC10aXRsZT48YWJici0xPkNsaW4uIE1pY3JvYmlvbC4gSW5mZWN0LjwvYWJici0xPjxhYmJyLTI+

Q2xpbiBNaWNyb2Jpb2wgSW5mZWN0PC9hYmJyLTI+PGFiYnItMz5DbGluaWNhbCBNaWNyb2Jpb2xv

Z3kgJmFtcDsgSW5mZWN0aW9uPC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxwYWdlcz5FMjcxLTc8L3Bh

Z2VzPjx2b2x1bWU+MTk8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48a2V5d29yZHM+PGtleXdv

cmQ+QmlvcHN5PC9rZXl3b3JkPjxrZXl3b3JkPipETkEsIEZ1bmdhbDwva2V5d29yZD48a2V5d29y

ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TXljb3Nlcy8qZGlhZ25vc2lzL21pY3JvYmlvbG9n

eTwva2V5d29yZD48a2V5d29yZD4qTnVjbGVpYyBBY2lkIEFtcGxpZmljYXRpb24gVGVjaG5pcXVl

cy9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlJlYWwtVGltZSBQb2x5bWVyYXNlIENoYWluIFJl

YWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlJlcHJvZHVjaWJpbGl0eSBvZiBSZXN1bHRzPC9rZXl3

b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5TZW5z

aXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAxMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVz

Pjxpc2JuPjE0NjktMDY5MSAoRWxlY3Ryb25pYykmI3hEOzExOTgtNzQzWCAoTGlua2luZyk8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+MjM0NjQ3NTE8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQt

dXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjM0NjQ3NTE8L3Vy

bD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMTEv

MTQ2OS0wNjkxLjEyMTEwPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+

PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [87-89]. Despite these promising results, Aspergillus PCR cannot yet be recommended for routine use in clinical practice because few assays have been standardized and validated, and the role of PCR testing in patient management is not established. Initiatives such as the European Aspergillus PCR Initiative (EAPCRI) have made significant progress in developing a consensus standard protocol for blood-based Aspergillus PCR. PCR assays are commercially available outside the US (MycAssay Aspergillus, Microgen Bioproducts Ltd, Camberley, UK); Septifast (Roche); MycoReal Aspergillus (Ingenetix GmbH); Affigene Aspergillus tracer (Cepheid); and Aspergillus spp. Q-PCR Alert (Nanogen); RenDx multiplex Aspergillus spp. & Candida spp. (whole blood, plasma & serum); AsperGenius (Pathonostics); Mycogenie (Ademtech) and others?) or centralization of PCR testing at a reference laboratory (ViraCor-IBT Laboratories (Lee’s Summit, MO)) and provide standardization but none have been cleared by the U.S. Food and Drug Administration (FDA) for clinical use in the U.S. These efforts now permit multi-center validation of assay performance and studies of clinical utility. Until such studies are completed, however, no specific recommendation about the role of Aspergillus PCR in clinical practice in the U.S. can be made.How should serum GM and (1→3)-β-D-glucan be used for the diagnosis of aspergillosis?Recommendations9.Serum and BAL GM is recommended as an accurate marker for the diagnosis of IA in adult and pediatric patients when used in certain patient subpopulations (hematologic malignancy, HSCT) (Strong Recommendation; High Quality Evidence). 10.GM is not recommended for routine blood screening in patients receiving mould-active antifungal therapy or prophylaxis, but can be applied to bronchoscopy specimens from those patients (Strong Recommendation; High Quality Evidence). 11.GM is not recommended for screening in solid organ transplant recipients or patients with CGD (Strong Recommendation; High Quality Evidence). 12.Serum assays for (1→3)-β-D-glucan are recommended for diagnosing IA in high risk patients (hematologic malignancy, allogeneic HSCT), but are not specific for Aspergillus (Strong Recommendation; Moderate Quality Evidence).Evidence summaryThe Platelia GM enzyme immunoassay (EIA) is a relatively Aspergillus-specific non-invasive diagnostic assay and several studies have demonstrated good sensitivity (~70%) in serum of patients with hematological malignancy or allogeneic HSCT PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IZXJicmVjaHQ8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFy

PjxSZWNOdW0+OTMwPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls5MC05NV08L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+OTMwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij45MzA8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkhlcmJyZWNodCwgUjwvYXV0aG9y

PjxhdXRob3I+TGV0c2NoZXItQnJ1LCBWPC9hdXRob3I+PGF1dGhvcj5PcHJlYSwgQzwvYXV0aG9y

PjxhdXRob3I+TGlvdXJlLCBCPC9hdXRob3I+PGF1dGhvcj5XYWxsZXIsIEo8L2F1dGhvcj48YXV0

aG9yPkNhbXBvcywgRjwvYXV0aG9yPjxhdXRob3I+VmlsbGFyZCwgTzwvYXV0aG9yPjxhdXRob3I+

TGl1LCBLLUw8L2F1dGhvcj48YXV0aG9yPk5hdGFyYWphbi1BbWUsIFM8L2F1dGhvcj48YXV0aG9y

Pkx1dHosIFA8L2F1dGhvcj48YXV0aG9yPkR1Zm91ciwgUDwvYXV0aG9yPjxhdXRob3I+QmVyZ2Vy

YXQsIEotUDwvYXV0aG9yPjxhdXRob3I+Q2FuZG9sZmksIEU8L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+PHN0eWxlIGZhY2U9Iml0YWxpYyIgZm9udD0iZGVm

YXVsdCIgc2l6ZT0iMTAwJSI+QXNwZXJnaWxsdXMgPC9zdHlsZT48c3R5bGUgZmFjZT0ibm9ybWFs

IiBmb250PSJkZWZhdWx0IiBzaXplPSIxMDAlIj5nYWxhY3RvbWFubmFuIGRldGVjdGlvbiBpbiB0

aGUgZGlhZ25vc2lzIG9mIGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgaW4gY2FuY2VyIHBhdGllbnRz

PC9zdHlsZT48L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNv

bG9neTwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpv

dXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIENsaW4gT25j

b2w8L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjE4OTgtMTkwNjwvcGFnZXM+PHZvbHVtZT43

PC92b2x1bWU+PGRhdGVzPjx5ZWFyPjIwMDI8L3llYXI+PC9kYXRlcz48dXJscz48L3VybHM+PC9y

ZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TWFycjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+

PFJlY051bT4xMjI5PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMjI5PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVk

dGRycHcwNWZmc2Z3cmV4Ij4xMjI5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5NYXJyLCBLLiBBLjwvYXV0aG9yPjxhdXRob3I+QmFsYWplZSwgUy4gQS48L2F1dGhvcj48

YXV0aG9yPk1jTGF1Z2hsaW4sIEwuPC9hdXRob3I+PGF1dGhvcj5UYWJvdXJldCwgTS48L2F1dGhv

cj48YXV0aG9yPkJlbnRzZW4sIEMuPC9hdXRob3I+PGF1dGhvcj5XYWxzaCwgVC4gSi48L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5GcmVkIEh1dGNoaW5zb24g

Q2FuY2VyIFJlc2VhcmNoIENlbnRlciBhbmQgVW5pdmVyc2l0eSBvZiBXYXNoaW5ndG9uLCBTZWF0

dGxlLCBXYXNoaW5ndG9uIDk4MTA5LCBVU0EuIGttYXJyQGZoY3JjLm9yZzwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPkRldGVjdGlvbiBvZiBnYWxhY3RvbWFubmFuIGFudGlnZW5lbWlhIGJ5

IGVuenltZSBpbW11bm9hc3NheSBmb3IgdGhlIGRpYWdub3NpcyBvZiBpbnZhc2l2ZSBhc3Blcmdp

bGxvc2lzOiB2YXJpYWJsZXMgdGhhdCBhZmZlY3QgcGVyZm9ybWFuY2U8L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+Sm91cm5hbCBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9zZWNvbmRhcnktdGl0bGU+

PGFsdC10aXRsZT5UaGUgSm91cm5hbCBvZiBpbmZlY3Rpb3VzIGRpc2Vhc2VzPC9hbHQtdGl0bGU+

PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBJbmZlY3Rpb3VzIERp

c2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBJbmZlY3QgRGlzPC9hYmJyLTE+PC9wZXJpb2Rp

Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5UaGUgSm91cm5hbCBvZiBJbmZlY3Rpb3Vz

IERpc2Vhc2VzPC9mdWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjY0MS05PC9wYWdl

cz48dm9sdW1lPjE5MDwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjIwMDQvMDcv

MTA8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdv

cmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BbmltYWxz

PC9rZXl3b3JkPjxrZXl3b3JkPkFudGlnZW5zLCBGdW5nYWwvIGJsb29kPC9rZXl3b3JkPjxrZXl3

b3JkPkFzcGVyZ2lsbG9zaXMvIGRpYWdub3Npcy9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdv

cmQ+QXNwZXJnaWxsdXMvIGlzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtl

eXdvcmQ+Qm9uZSBNYXJyb3cgVHJhbnNwbGFudGF0aW9uL2FkdmVyc2UgZWZmZWN0czwva2V5d29y

ZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3

b3JkPjxrZXl3b3JkPkRpc2Vhc2UgTW9kZWxzLCBBbmltYWw8L2tleXdvcmQ+PGtleXdvcmQ+RmVt

YWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZ1bmdlbWlhLyBkaWFnbm9zaXMvbWljcm9iaW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9lbnp5bWUgVGVj

aG5pcXVlczwva2V5d29yZD48a2V5d29yZD5MdW5nIERpc2Vhc2VzLCBGdW5nYWwvZGlhZ25vc2lz

L21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1h

bm5hbnMvIGJsb29kPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3

b3JkPlJhYmJpdHM8L2tleXdvcmQ+PGtleXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDQ8L3llYXI+PHB1Yi1kYXRlcz48

ZGF0ZT5BdWcgMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMjItMTg5OSAoUHJp

bnQpJiN4RDswMDIyLTE4OTkgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE1MjQzOTQz

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAu

MTA4Ni80MjIwMDk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJv

dmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3Vh

Z2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TWFlcnRlbnM8L0F1dGhvcj48WWVhcj4y

MDA1PC9ZZWFyPjxSZWNOdW0+MTIzMDwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTIzMDwv

cmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImZwd2VkMnByOXph

dnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+MTIzMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYt

dHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxh

dXRob3JzPjxhdXRob3I+TWFlcnRlbnMsIEouPC9hdXRob3I+PGF1dGhvcj5HbGFzbWFjaGVyLCBB

LjwvYXV0aG9yPjxhdXRob3I+U2VsbGVzbGFnLCBELjwvYXV0aG9yPjxhdXRob3I+TmdhaSwgQS48

L2F1dGhvcj48YXV0aG9yPlJ5YW4sIEQuPC9hdXRob3I+PGF1dGhvcj5MYXl0b24sIE0uPC9hdXRo

b3I+PGF1dGhvcj5UYXlsb3IsIEEuPC9hdXRob3I+PGF1dGhvcj5TYWJsZSwgQy48L2F1dGhvcj48

YXV0aG9yPkthcnRzb25pcywgTi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1

dGgtYWRkcmVzcz5Vbml2ZXJzaXR5IEhvc3BpdGFsIEdhc3RodWlzYmVyZywgTGV1dmVuLCBCZWxn

aXVtLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkV2YWx1YXRpb24gb2Ygc2VydW0gc2Fu

ZHdpY2ggZW56eW1lLWxpbmtlZCBpbW11bm9zb3JiZW50IGFzc2F5IGZvciBjaXJjdWxhdGluZyBn

YWxhY3RvbWFubmFuIGR1cmluZyBjYXNwb2Z1bmdpbiB0aGVyYXB5OiByZXN1bHRzIGZyb20gdGhl

IGNhc3BvZnVuZ2luIGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgc3R1ZHk8L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+Q2xpbmljYWwgSW5mZWN0aW91cyBEaXNlYXNlczwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+Q2xpbmljYWwgaW5mZWN0aW91cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1Ymxp

Y2F0aW9uIG9mIHRoZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlv

dXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5DbGluIEluZmVjdCBEaXM8L2FiYnItMT48

L3BlcmlvZGljYWw+PHBhZ2VzPmU5LTE0PC9wYWdlcz48dm9sdW1lPjQxPC92b2x1bWU+PG51bWJl

cj4xPC9udW1iZXI+PGVkaXRpb24+MjAwNS8wNi8wNzwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdv

cmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BbnRpZnVu

Z2FsIEFnZW50cy8gdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlnZW5zLCBG

dW5nYWwvIGJsb29kPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvIGRydWcgdGhlcmFw

eS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RWNoaW5vY2FuZGluczwva2V5d29yZD48

a2V5d29yZD5Fbnp5bWUtTGlua2VkIEltbXVub3NvcmJlbnQgQXNzYXk8L2tleXdvcmQ+PGtleXdv

cmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5MdW5n

IERpc2Vhc2VzLCBGdW5nYWwvIGRydWcgdGhlcmFweS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtl

eXdvcmQ+TWFubmFucy8gYmxvb2Q8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdv

cmQ+PGtleXdvcmQ+UGVwdGlkZXMsIEN5Y2xpYy8gdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxr

ZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy

PjIwMDU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdWwgMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh

dGVzPjxpc2JuPjE1MzctNjU5MSAoRWxlY3Ryb25pYykmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTU5Mzc3NTQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxz

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDg2LzQzMDgyNjwvZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1

dGhvcj5NYWVydGVuczwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+PFJlY051bT4xMjMyPC9SZWNO

dW0+PHJlY29yZD48cmVjLW51bWJlcj4xMjMyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4x

MjMyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NYWVydGVucywgSi48

L2F1dGhvcj48YXV0aG9yPlZhbiBFbGRlcmUsIEouPC9hdXRob3I+PGF1dGhvcj5WZXJoYWVnZW4s

IEouPC9hdXRob3I+PGF1dGhvcj5WZXJiZWtlbiwgRS48L2F1dGhvcj48YXV0aG9yPlZlcnNjaGFr

ZWxlbiwgSi48L2F1dGhvcj48YXV0aG9yPkJvb2dhZXJ0cywgTS48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIEhlbWF0b2xvZ3ksIFVu

aXZlcnNpdHkgSG9zcGl0YWwgR2FzdGh1aXNiZXJnLCBMZXV2ZW4sIEJlbGdpdW0uIGpvaGFuLm1h

ZXJ0ZW5zQHV6Lmt1bGV1dmVuLmFjLmJlPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VXNl

IG9mIGNpcmN1bGF0aW5nIGdhbGFjdG9tYW5uYW4gc2NyZWVuaW5nIGZvciBlYXJseSBkaWFnbm9z

aXMgb2YgaW52YXNpdmUgYXNwZXJnaWxsb3NpcyBpbiBhbGxvZ2VuZWljIHN0ZW0gY2VsbCB0cmFu

c3BsYW50IHJlY2lwaWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiBJbmZl

Y3Rpb3VzIERpc2Vhc2VzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5UaGUgSm91cm5hbCBv

ZiBpbmZlY3Rpb3VzIGRpc2Vhc2VzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+Sm91cm5hbCBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJy

LTE+SiBJbmZlY3QgRGlzPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5UaGUgSm91cm5hbCBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjwv

YWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEyOTctMzA2PC9wYWdlcz48dm9sdW1lPjE4Njwvdm9sdW1l

PjxudW1iZXI+OTwvbnVtYmVyPjxlZGl0aW9uPjIwMDIvMTAvMjk8L2VkaXRpb24+PGtleXdvcmRz

PjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtl

eXdvcmQ+QWdlIERpc3RyaWJ1dGlvbjwva2V5d29yZD48a2V5d29yZD5BbmVtaWEsIEFwbGFzdGlj

L3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9ibG9vZC8gZGlhZ25vc2lz

PC9rZXl3b3JkPjxrZXl3b3JkPkJpb2xvZ2ljYWwgTWFya2Vycy9ibG9vZDwva2V5d29yZD48a2V5

d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvbG9naWMgTmVvcGxhc21zL3RoZXJh

cHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdv

cmQ+PGtleXdvcmQ+TWFubmFucy8gYmxvb2Q8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8

L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+U3Rl

bSBDZWxsIFRyYW5zcGxhbnRhdGlvbi8gYWR2ZXJzZSBlZmZlY3RzL21vcnRhbGl0eTwva2V5d29y

ZD48a2V5d29yZD5TdXJ2aXZhbCBBbmFseXNpczwva2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3Rv

cnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJhbnNwbGFudGF0aW9uLCBIb21vbG9nb3VzL2FkdmVyc2Ug

ZWZmZWN0cy9tb3J0YWxpdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMjwv

eWVhcj48cHViLWRhdGVzPjxkYXRlPk5vdiAxPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlz

Ym4+MDAyMi0xODk5IChQcmludCkmI3hEOzAwMjItMTg5OSAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MTI0MDIxOTk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT4xMC4xMDg2LzM0MzgwNDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFu

Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NYWVydGVu

czwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJlY051bT4xMjMxPC9SZWNOdW0+PHJlY29yZD48

cmVjLW51bWJlcj4xMjMxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjMxPC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NYWVydGVucywgSi4gQS48L2F1dGhvcj48

YXV0aG9yPktsb250LCBSLjwvYXV0aG9yPjxhdXRob3I+TWFzc29uLCBDLjwvYXV0aG9yPjxhdXRo

b3I+VGhldW5pc3NlbiwgSy48L2F1dGhvcj48YXV0aG9yPk1lZXJzc2VtYW4sIFcuPC9hdXRob3I+

PGF1dGhvcj5MYWdyb3UsIEsuPC9hdXRob3I+PGF1dGhvcj5IZWluZW4sIEMuPC9hdXRob3I+PGF1

dGhvcj5DcmVwaW4sIEIuPC9hdXRob3I+PGF1dGhvcj5WYW4gRWxkZXJlLCBKLjwvYXV0aG9yPjxh

dXRob3I+VGFib3VyZXQsIE0uPC9hdXRob3I+PGF1dGhvcj5Eb25uZWxseSwgSi4gUC48L2F1dGhv

cj48YXV0aG9yPlZlcndlaWosIFAuIEUuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBIZW1hdG9sb2d5LCBVbml2ZXJzaXRhaXJlIFpp

ZWtlbmh1aXplbiwgQ2F0aG9saWMgVW5pdmVyc2l0eSBMZXV2ZW4sIExldXZlbiwgQmVsZ2l1bS4g

am9oYW4ubWFlcnRlbnNAdXoua3VsZXV2ZW4uYWMuYmU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0

aXRsZT5PcHRpbWl6YXRpb24gb2YgdGhlIGN1dG9mZiB2YWx1ZSBmb3IgdGhlIEFzcGVyZ2lsbHVz

IGRvdWJsZS1zYW5kd2ljaCBlbnp5bWUgaW1tdW5vYXNzYXk8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+Q2xpbmljYWwgSW5mZWN0aW91cyBEaXNlYXNlczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0

bGU+Q2xpbmljYWwgaW5mZWN0aW91cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9u

IG9mIHRoZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlz

ZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5DbGluIEluZmVjdCBEaXM8L2FiYnItMT48L3Blcmlv

ZGljYWw+PHBhZ2VzPjEzMjktMzY8L3BhZ2VzPjx2b2x1bWU+NDQ8L3ZvbHVtZT48bnVtYmVyPjEw

PC9udW1iZXI+PGVkaXRpb24+MjAwNy8wNC8yMDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+

QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2Vk

PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvYmxvb2QvIGRpYWdub3Npcy9taWNyb2Jp

b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvIGlzb2xhdGlvbiAmYW1wOyBwdXJp

ZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFu

czwva2V5d29yZD48a2V5d29yZD5JbW11bm9lbnp5bWUgVGVjaG5pcXVlcy8gbWV0aG9kcy9zdGFu

ZGFyZHM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5zL2Fu

YWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk5l

dXRyb3BlbmlhL2ltbXVub2xvZ3kvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJPQyBD

dXJ2ZTwva2V5d29yZD48a2V5d29yZD5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtl

eXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMDc8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXkgMTU8L2RhdGU+PC9wdWIt

ZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU4LTQ4Mzgg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE3NDQzNDcwPC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA4Ni81MTQzNDk8L2VsZWN0

cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUt

ZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRl

PjxDaXRlPjxBdXRob3I+UGZlaWZmZXI8L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFyPjxSZWNOdW0+

MTA5MDwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTA5MDwvcmVjLW51bWJlcj48Zm9yZWln

bi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVm

ZnNmd3JleCI+MTA5MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UGZl

aWZmZXIsIEMgRDwvYXV0aG9yPjxhdXRob3I+RmluZSwgSiBQPC9hdXRob3I+PGF1dGhvcj5TYWZk

YXIsIE48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+RGlh

Z25vc2lzIG9mIGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgdXNpbmcgYSBnYWxhY3RvbWFubmFuIGFz

c2F5OiBhIG1ldGEtYW5hbHlzaXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2xpbmljYWwgSW5m

ZWN0aW91cyBEaXNlYXNlczwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnIt

MT5DbGluIEluZmVjdCBEaXM8L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjE0MTctMjc8L3Bh

Z2VzPjx2b2x1bWU+NDI8L3ZvbHVtZT48ZGF0ZXM+PHllYXI+MjAwNjwveWVhcj48L2RhdGVzPjx1

cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IZXJicmVjaHQ8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFy

PjxSZWNOdW0+OTMwPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls5MC05NV08L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+OTMwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij45MzA8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkhlcmJyZWNodCwgUjwvYXV0aG9y

PjxhdXRob3I+TGV0c2NoZXItQnJ1LCBWPC9hdXRob3I+PGF1dGhvcj5PcHJlYSwgQzwvYXV0aG9y

PjxhdXRob3I+TGlvdXJlLCBCPC9hdXRob3I+PGF1dGhvcj5XYWxsZXIsIEo8L2F1dGhvcj48YXV0

aG9yPkNhbXBvcywgRjwvYXV0aG9yPjxhdXRob3I+VmlsbGFyZCwgTzwvYXV0aG9yPjxhdXRob3I+

TGl1LCBLLUw8L2F1dGhvcj48YXV0aG9yPk5hdGFyYWphbi1BbWUsIFM8L2F1dGhvcj48YXV0aG9y

Pkx1dHosIFA8L2F1dGhvcj48YXV0aG9yPkR1Zm91ciwgUDwvYXV0aG9yPjxhdXRob3I+QmVyZ2Vy

YXQsIEotUDwvYXV0aG9yPjxhdXRob3I+Q2FuZG9sZmksIEU8L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+PHN0eWxlIGZhY2U9Iml0YWxpYyIgZm9udD0iZGVm

YXVsdCIgc2l6ZT0iMTAwJSI+QXNwZXJnaWxsdXMgPC9zdHlsZT48c3R5bGUgZmFjZT0ibm9ybWFs

IiBmb250PSJkZWZhdWx0IiBzaXplPSIxMDAlIj5nYWxhY3RvbWFubmFuIGRldGVjdGlvbiBpbiB0

aGUgZGlhZ25vc2lzIG9mIGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgaW4gY2FuY2VyIHBhdGllbnRz

PC9zdHlsZT48L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNv

bG9neTwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpv

dXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIENsaW4gT25j

b2w8L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjE4OTgtMTkwNjwvcGFnZXM+PHZvbHVtZT43

PC92b2x1bWU+PGRhdGVzPjx5ZWFyPjIwMDI8L3llYXI+PC9kYXRlcz48dXJscz48L3VybHM+PC9y

ZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TWFycjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+

PFJlY051bT4xMjI5PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMjI5PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVk

dGRycHcwNWZmc2Z3cmV4Ij4xMjI5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5NYXJyLCBLLiBBLjwvYXV0aG9yPjxhdXRob3I+QmFsYWplZSwgUy4gQS48L2F1dGhvcj48

YXV0aG9yPk1jTGF1Z2hsaW4sIEwuPC9hdXRob3I+PGF1dGhvcj5UYWJvdXJldCwgTS48L2F1dGhv

cj48YXV0aG9yPkJlbnRzZW4sIEMuPC9hdXRob3I+PGF1dGhvcj5XYWxzaCwgVC4gSi48L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5GcmVkIEh1dGNoaW5zb24g

Q2FuY2VyIFJlc2VhcmNoIENlbnRlciBhbmQgVW5pdmVyc2l0eSBvZiBXYXNoaW5ndG9uLCBTZWF0

dGxlLCBXYXNoaW5ndG9uIDk4MTA5LCBVU0EuIGttYXJyQGZoY3JjLm9yZzwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPkRldGVjdGlvbiBvZiBnYWxhY3RvbWFubmFuIGFudGlnZW5lbWlhIGJ5

IGVuenltZSBpbW11bm9hc3NheSBmb3IgdGhlIGRpYWdub3NpcyBvZiBpbnZhc2l2ZSBhc3Blcmdp

bGxvc2lzOiB2YXJpYWJsZXMgdGhhdCBhZmZlY3QgcGVyZm9ybWFuY2U8L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+Sm91cm5hbCBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9zZWNvbmRhcnktdGl0bGU+

PGFsdC10aXRsZT5UaGUgSm91cm5hbCBvZiBpbmZlY3Rpb3VzIGRpc2Vhc2VzPC9hbHQtdGl0bGU+

PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBJbmZlY3Rpb3VzIERp

c2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBJbmZlY3QgRGlzPC9hYmJyLTE+PC9wZXJpb2Rp

Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5UaGUgSm91cm5hbCBvZiBJbmZlY3Rpb3Vz

IERpc2Vhc2VzPC9mdWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjY0MS05PC9wYWdl

cz48dm9sdW1lPjE5MDwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjIwMDQvMDcv

MTA8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdv

cmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BbmltYWxz

PC9rZXl3b3JkPjxrZXl3b3JkPkFudGlnZW5zLCBGdW5nYWwvIGJsb29kPC9rZXl3b3JkPjxrZXl3

b3JkPkFzcGVyZ2lsbG9zaXMvIGRpYWdub3Npcy9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdv

cmQ+QXNwZXJnaWxsdXMvIGlzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtl

eXdvcmQ+Qm9uZSBNYXJyb3cgVHJhbnNwbGFudGF0aW9uL2FkdmVyc2UgZWZmZWN0czwva2V5d29y

ZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3

b3JkPjxrZXl3b3JkPkRpc2Vhc2UgTW9kZWxzLCBBbmltYWw8L2tleXdvcmQ+PGtleXdvcmQ+RmVt

YWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZ1bmdlbWlhLyBkaWFnbm9zaXMvbWljcm9iaW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9lbnp5bWUgVGVj

aG5pcXVlczwva2V5d29yZD48a2V5d29yZD5MdW5nIERpc2Vhc2VzLCBGdW5nYWwvZGlhZ25vc2lz

L21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1h

bm5hbnMvIGJsb29kPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3

b3JkPlJhYmJpdHM8L2tleXdvcmQ+PGtleXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDQ8L3llYXI+PHB1Yi1kYXRlcz48

ZGF0ZT5BdWcgMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMjItMTg5OSAoUHJp

bnQpJiN4RDswMDIyLTE4OTkgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE1MjQzOTQz

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAu

MTA4Ni80MjIwMDk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJv

dmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3Vh

Z2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TWFlcnRlbnM8L0F1dGhvcj48WWVhcj4y

MDA1PC9ZZWFyPjxSZWNOdW0+MTIzMDwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTIzMDwv

cmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImZwd2VkMnByOXph

dnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+MTIzMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYt

dHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxh

dXRob3JzPjxhdXRob3I+TWFlcnRlbnMsIEouPC9hdXRob3I+PGF1dGhvcj5HbGFzbWFjaGVyLCBB

LjwvYXV0aG9yPjxhdXRob3I+U2VsbGVzbGFnLCBELjwvYXV0aG9yPjxhdXRob3I+TmdhaSwgQS48

L2F1dGhvcj48YXV0aG9yPlJ5YW4sIEQuPC9hdXRob3I+PGF1dGhvcj5MYXl0b24sIE0uPC9hdXRo

b3I+PGF1dGhvcj5UYXlsb3IsIEEuPC9hdXRob3I+PGF1dGhvcj5TYWJsZSwgQy48L2F1dGhvcj48

YXV0aG9yPkthcnRzb25pcywgTi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1

dGgtYWRkcmVzcz5Vbml2ZXJzaXR5IEhvc3BpdGFsIEdhc3RodWlzYmVyZywgTGV1dmVuLCBCZWxn

aXVtLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkV2YWx1YXRpb24gb2Ygc2VydW0gc2Fu

ZHdpY2ggZW56eW1lLWxpbmtlZCBpbW11bm9zb3JiZW50IGFzc2F5IGZvciBjaXJjdWxhdGluZyBn

YWxhY3RvbWFubmFuIGR1cmluZyBjYXNwb2Z1bmdpbiB0aGVyYXB5OiByZXN1bHRzIGZyb20gdGhl

IGNhc3BvZnVuZ2luIGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgc3R1ZHk8L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+Q2xpbmljYWwgSW5mZWN0aW91cyBEaXNlYXNlczwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+Q2xpbmljYWwgaW5mZWN0aW91cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1Ymxp

Y2F0aW9uIG9mIHRoZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlv

dXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5DbGluIEluZmVjdCBEaXM8L2FiYnItMT48

L3BlcmlvZGljYWw+PHBhZ2VzPmU5LTE0PC9wYWdlcz48dm9sdW1lPjQxPC92b2x1bWU+PG51bWJl

cj4xPC9udW1iZXI+PGVkaXRpb24+MjAwNS8wNi8wNzwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdv

cmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BbnRpZnVu

Z2FsIEFnZW50cy8gdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlnZW5zLCBG

dW5nYWwvIGJsb29kPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvIGRydWcgdGhlcmFw

eS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RWNoaW5vY2FuZGluczwva2V5d29yZD48

a2V5d29yZD5Fbnp5bWUtTGlua2VkIEltbXVub3NvcmJlbnQgQXNzYXk8L2tleXdvcmQ+PGtleXdv

cmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5MdW5n

IERpc2Vhc2VzLCBGdW5nYWwvIGRydWcgdGhlcmFweS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtl

eXdvcmQ+TWFubmFucy8gYmxvb2Q8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdv

cmQ+PGtleXdvcmQ+UGVwdGlkZXMsIEN5Y2xpYy8gdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxr

ZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy

PjIwMDU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdWwgMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh

dGVzPjxpc2JuPjE1MzctNjU5MSAoRWxlY3Ryb25pYykmI3hEOzEwNTgtNDgzOCAoTGlua2luZyk8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTU5Mzc3NTQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxz

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDg2LzQzMDgyNjwvZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1

dGhvcj5NYWVydGVuczwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+PFJlY051bT4xMjMyPC9SZWNO

dW0+PHJlY29yZD48cmVjLW51bWJlcj4xMjMyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4x

MjMyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NYWVydGVucywgSi48

L2F1dGhvcj48YXV0aG9yPlZhbiBFbGRlcmUsIEouPC9hdXRob3I+PGF1dGhvcj5WZXJoYWVnZW4s

IEouPC9hdXRob3I+PGF1dGhvcj5WZXJiZWtlbiwgRS48L2F1dGhvcj48YXV0aG9yPlZlcnNjaGFr

ZWxlbiwgSi48L2F1dGhvcj48YXV0aG9yPkJvb2dhZXJ0cywgTS48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIEhlbWF0b2xvZ3ksIFVu

aXZlcnNpdHkgSG9zcGl0YWwgR2FzdGh1aXNiZXJnLCBMZXV2ZW4sIEJlbGdpdW0uIGpvaGFuLm1h

ZXJ0ZW5zQHV6Lmt1bGV1dmVuLmFjLmJlPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VXNl

IG9mIGNpcmN1bGF0aW5nIGdhbGFjdG9tYW5uYW4gc2NyZWVuaW5nIGZvciBlYXJseSBkaWFnbm9z

aXMgb2YgaW52YXNpdmUgYXNwZXJnaWxsb3NpcyBpbiBhbGxvZ2VuZWljIHN0ZW0gY2VsbCB0cmFu

c3BsYW50IHJlY2lwaWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiBJbmZl

Y3Rpb3VzIERpc2Vhc2VzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5UaGUgSm91cm5hbCBv

ZiBpbmZlY3Rpb3VzIGRpc2Vhc2VzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+Sm91cm5hbCBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJy

LTE+SiBJbmZlY3QgRGlzPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5UaGUgSm91cm5hbCBvZiBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjwv

YWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEyOTctMzA2PC9wYWdlcz48dm9sdW1lPjE4Njwvdm9sdW1l

PjxudW1iZXI+OTwvbnVtYmVyPjxlZGl0aW9uPjIwMDIvMTAvMjk8L2VkaXRpb24+PGtleXdvcmRz

PjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtl

eXdvcmQ+QWdlIERpc3RyaWJ1dGlvbjwva2V5d29yZD48a2V5d29yZD5BbmVtaWEsIEFwbGFzdGlj

L3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9ibG9vZC8gZGlhZ25vc2lz

PC9rZXl3b3JkPjxrZXl3b3JkPkJpb2xvZ2ljYWwgTWFya2Vycy9ibG9vZDwva2V5d29yZD48a2V5

d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvbG9naWMgTmVvcGxhc21zL3RoZXJh

cHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdv

cmQ+PGtleXdvcmQ+TWFubmFucy8gYmxvb2Q8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8

L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL3RoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+U3Rl

bSBDZWxsIFRyYW5zcGxhbnRhdGlvbi8gYWR2ZXJzZSBlZmZlY3RzL21vcnRhbGl0eTwva2V5d29y

ZD48a2V5d29yZD5TdXJ2aXZhbCBBbmFseXNpczwva2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3Rv

cnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJhbnNwbGFudGF0aW9uLCBIb21vbG9nb3VzL2FkdmVyc2Ug

ZWZmZWN0cy9tb3J0YWxpdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMjwv

eWVhcj48cHViLWRhdGVzPjxkYXRlPk5vdiAxPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlz

Ym4+MDAyMi0xODk5IChQcmludCkmI3hEOzAwMjItMTg5OSAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MTI0MDIxOTk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT4xMC4xMDg2LzM0MzgwNDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFu

Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NYWVydGVu

czwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJlY051bT4xMjMxPC9SZWNOdW0+PHJlY29yZD48

cmVjLW51bWJlcj4xMjMxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjMxPC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NYWVydGVucywgSi4gQS48L2F1dGhvcj48

YXV0aG9yPktsb250LCBSLjwvYXV0aG9yPjxhdXRob3I+TWFzc29uLCBDLjwvYXV0aG9yPjxhdXRo

b3I+VGhldW5pc3NlbiwgSy48L2F1dGhvcj48YXV0aG9yPk1lZXJzc2VtYW4sIFcuPC9hdXRob3I+

PGF1dGhvcj5MYWdyb3UsIEsuPC9hdXRob3I+PGF1dGhvcj5IZWluZW4sIEMuPC9hdXRob3I+PGF1

dGhvcj5DcmVwaW4sIEIuPC9hdXRob3I+PGF1dGhvcj5WYW4gRWxkZXJlLCBKLjwvYXV0aG9yPjxh

dXRob3I+VGFib3VyZXQsIE0uPC9hdXRob3I+PGF1dGhvcj5Eb25uZWxseSwgSi4gUC48L2F1dGhv

cj48YXV0aG9yPlZlcndlaWosIFAuIEUuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBIZW1hdG9sb2d5LCBVbml2ZXJzaXRhaXJlIFpp

ZWtlbmh1aXplbiwgQ2F0aG9saWMgVW5pdmVyc2l0eSBMZXV2ZW4sIExldXZlbiwgQmVsZ2l1bS4g

am9oYW4ubWFlcnRlbnNAdXoua3VsZXV2ZW4uYWMuYmU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0

aXRsZT5PcHRpbWl6YXRpb24gb2YgdGhlIGN1dG9mZiB2YWx1ZSBmb3IgdGhlIEFzcGVyZ2lsbHVz

IGRvdWJsZS1zYW5kd2ljaCBlbnp5bWUgaW1tdW5vYXNzYXk8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+Q2xpbmljYWwgSW5mZWN0aW91cyBEaXNlYXNlczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0

bGU+Q2xpbmljYWwgaW5mZWN0aW91cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9u

IG9mIHRoZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlz

ZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5DbGluIEluZmVjdCBEaXM8L2FiYnItMT48L3Blcmlv

ZGljYWw+PHBhZ2VzPjEzMjktMzY8L3BhZ2VzPjx2b2x1bWU+NDQ8L3ZvbHVtZT48bnVtYmVyPjEw

PC9udW1iZXI+PGVkaXRpb24+MjAwNy8wNC8yMDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+

QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2Vk

PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbG9zaXMvYmxvb2QvIGRpYWdub3Npcy9taWNyb2Jp

b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvIGlzb2xhdGlvbiAmYW1wOyBwdXJp

ZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFu

czwva2V5d29yZD48a2V5d29yZD5JbW11bm9lbnp5bWUgVGVjaG5pcXVlcy8gbWV0aG9kcy9zdGFu

ZGFyZHM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5zL2Fu

YWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk5l

dXRyb3BlbmlhL2ltbXVub2xvZ3kvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJPQyBD

dXJ2ZTwva2V5d29yZD48a2V5d29yZD5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtl

eXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMDc8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXkgMTU8L2RhdGU+PC9wdWIt

ZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU4LTQ4Mzgg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE3NDQzNDcwPC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA4Ni81MTQzNDk8L2VsZWN0

cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUt

ZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRl

PjxDaXRlPjxBdXRob3I+UGZlaWZmZXI8L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFyPjxSZWNOdW0+

MTA5MDwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTA5MDwvcmVjLW51bWJlcj48Zm9yZWln

bi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVm

ZnNmd3JleCI+MTA5MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UGZl

aWZmZXIsIEMgRDwvYXV0aG9yPjxhdXRob3I+RmluZSwgSiBQPC9hdXRob3I+PGF1dGhvcj5TYWZk

YXIsIE48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+RGlh

Z25vc2lzIG9mIGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgdXNpbmcgYSBnYWxhY3RvbWFubmFuIGFz

c2F5OiBhIG1ldGEtYW5hbHlzaXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2xpbmljYWwgSW5m

ZWN0aW91cyBEaXNlYXNlczwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnIt

MT5DbGluIEluZmVjdCBEaXM8L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjE0MTctMjc8L3Bh

Z2VzPjx2b2x1bWU+NDI8L3ZvbHVtZT48ZGF0ZXM+PHllYXI+MjAwNjwveWVhcj48L2RhdGVzPjx1

cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [90-95]. A GM-based diagnostic strategy can also result in less empiric antifungal therapy usage PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3JyaXNzZXk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy

PjxSZWNOdW0+MjcwPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls4MCwgOTZdPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjI3MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0

YW1wPSIxNDEzODQ4MjQ3Ij4yNzA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPk1vcnJpc3NleSwgQy4gTy48L2F1dGhvcj48YXV0aG9yPkNoZW4sIFMuIEMuPC9hdXRob3I+

PGF1dGhvcj5Tb3JyZWxsLCBULiBDLjwvYXV0aG9yPjxhdXRob3I+TWlsbGlrZW4sIFMuPC9hdXRo

b3I+PGF1dGhvcj5CYXJkeSwgUC4gRy48L2F1dGhvcj48YXV0aG9yPkJyYWRzdG9jaywgSy4gRi48

L2F1dGhvcj48YXV0aG9yPlN6ZXIsIEouPC9hdXRob3I+PGF1dGhvcj5IYWxsaWRheSwgQy4gTC48

L2F1dGhvcj48YXV0aG9yPkdpbHJveSwgTi4gTS48L2F1dGhvcj48YXV0aG9yPk1vb3JlLCBKLjwv

YXV0aG9yPjxhdXRob3I+U2Nod2FyZXIsIEEuIFAuPC9hdXRob3I+PGF1dGhvcj5HdXksIFMuPC9h

dXRob3I+PGF1dGhvcj5CYWplbCwgQS48L2F1dGhvcj48YXV0aG9yPlRyYW1vbnRhbmEsIEEuIFIu

PC9hdXRob3I+PGF1dGhvcj5TcGVsbWFuLCBULjwvYXV0aG9yPjxhdXRob3I+U2xhdmluLCBNLiBB

LjwvYXV0aG9yPjxhdXRob3I+QXVzdHJhbGFzaWFuIExldWthZW1pYSBMeW1waG9tYSwgR3JvdXA8

L2F1dGhvcj48YXV0aG9yPnRoZSwgQXVzdHJhbGlhPC9hdXRob3I+PGF1dGhvcj5OZXcgWmVhbGFu

ZCBNeWNvbG9neSBJbnRlcmVzdCwgR3JvdXA8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5JbmZlY3Rpb3VzIERpc2Vhc2VzIFVuaXQsIEFsZnJlZCBIZWFsdGgs

IGFuZCBEZXBhcnRtZW50IG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIENlbnRyYWwgQ2xpbmljYWwg

U2Nob29sLCBNb25hc2ggVW5pdmVyc2l0eSwgTWVsYm91cm5lLCBWSUMsIEF1c3RyYWxpYS4gby5t

b3JyaXNzZXlAYWxmcmVkLm9yZy5hdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkdhbGFj

dG9tYW5uYW4gYW5kIFBDUiB2ZXJzdXMgY3VsdHVyZSBhbmQgaGlzdG9sb2d5IGZvciBkaXJlY3Rp

bmcgdXNlIG9mIGFudGlmdW5nYWwgdHJlYXRtZW50IGZvciBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lz

IGluIGhpZ2gtcmlzayBoYWVtYXRvbG9neSBwYXRpZW50czogYSByYW5kb21pc2VkIGNvbnRyb2xs

ZWQgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TGFuY2V0IEluZmVjdCBEaXM8L3NlY29u

ZGFyeS10aXRsZT48YWx0LXRpdGxlPlRoZSBMYW5jZXQuIEluZmVjdGlvdXMgZGlzZWFzZXM8L2Fs

dC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5MYW5jZXQgSW5mZWN0aW91

cyBEaXNlYXNlczwvZnVsbC10aXRsZT48YWJici0xPkxhbmNldCBJbmZlY3QuIERpcy48L2FiYnIt

MT48YWJici0yPkxhbmNldCBJbmZlY3QgRGlzPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz41

MTktMjg8L3BhZ2VzPjx2b2x1bWU+MTM8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48a2V5d29y

ZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWZ1bmdhbCBBZ2VudHMvKnRo

ZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2RpYWdub3Npcy8q

ZHJ1ZyB0aGVyYXB5LyptZXRhYm9saXNtL3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5Bc3Bl

cmdpbGx1cy8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbi9wYXRob2dlbmljaXR5PC9rZXl3

b3JkPjxrZXl3b3JkPkJpb2xvZ2ljYWwgTWFya2Vycy9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3

b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwva2V5d29yZD48

a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TGV1a2VtaWEsIEx5bXBob2lkL2RydWcg

dGhlcmFweS8qbWljcm9iaW9sb2d5L3N1cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5

d29yZD48a2V5d29yZD5NYW5uYW5zLyptZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRs

ZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb24vKm1ldGhv

ZHM8L2tleXdvcmQ+PGtleXdvcmQ+U3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbjwva2V5d29yZD48

a2V5d29yZD5UcmFuc3BsYW50YXRpb24sIEhvbW9sb2dvdXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48

ZGF0ZXM+PHllYXI+MjAxMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1k

YXRlcz48L2RhdGVzPjxpc2JuPjE0NzQtNDQ1NyAoRWxlY3Ryb25pYykmI3hEOzE0NzMtMzA5OSAo

TGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjM2Mzk2MTI8L2FjY2Vzc2lvbi1udW0+PHVy

bHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQv

MjM2Mzk2MTI8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjEwLjEwMTYvUzE0NzMtMzA5OSgxMyk3MDA3Ni04PC9lbGVjdHJvbmljLXJlc291cmNlLW51

bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NYWVydGVuczwvQXV0aG9yPjxZZWFyPjIw

MDU8L1llYXI+PFJlY051bT4xMjMzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMjMzPC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2

dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjMzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10

eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1

dGhvcnM+PGF1dGhvcj5NYWVydGVucywgSi48L2F1dGhvcj48YXV0aG9yPlRoZXVuaXNzZW4sIEsu

PC9hdXRob3I+PGF1dGhvcj5WZXJob2VmLCBHLjwvYXV0aG9yPjxhdXRob3I+VmVyc2NoYWtlbGVu

LCBKLjwvYXV0aG9yPjxhdXRob3I+TGFncm91LCBLLjwvYXV0aG9yPjxhdXRob3I+VmVyYmVrZW4s

IEUuPC9hdXRob3I+PGF1dGhvcj5XaWxtZXIsIEEuPC9hdXRob3I+PGF1dGhvcj5WZXJoYWVnZW4s

IEouPC9hdXRob3I+PGF1dGhvcj5Cb29nYWVydHMsIE0uPC9hdXRob3I+PGF1dGhvcj5WYW4gRWxk

ZXJlLCBKLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRl

cGFydG1lbnQgb2YgSGVtYXRvbG9neSwgVW5pdmVyc2l0eSBIb3NwaXRhbCBHYXN0aHVpc2Jlcmcs

IExldXZlbiwgQmVsZ2l1bS4gam9oYW4ubWFlcnRlbnNAdXoua3VsZXV2ZW4uYWMuYmU8L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5HYWxhY3RvbWFubmFuIGFuZCBjb21wdXRlZCB0b21vZ3Jh

cGh5LWJhc2VkIHByZWVtcHRpdmUgYW50aWZ1bmdhbCB0aGVyYXB5IGluIG5ldXRyb3BlbmljIHBh

dGllbnRzIGF0IGhpZ2ggcmlzayBmb3IgaW52YXNpdmUgZnVuZ2FsIGluZmVjdGlvbjogYSBwcm9z

cGVjdGl2ZSBmZWFzaWJpbGl0eSBzdHVkeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluaWNh

bCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5DbGluaWNh

bCBpbmZlY3Rpb3VzIGRpc2Vhc2VzIDogYW4gb2ZmaWNpYWwgcHVibGljYXRpb24gb2YgdGhlIElu

ZmVjdGlvdXMgRGlzZWFzZXMgU29jaWV0eSBvZiBBbWVyaWNhPC9hbHQtdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2xpbmljYWwgSW5mZWN0aW91cyBEaXNlYXNlczwvZnVs

bC10aXRsZT48YWJici0xPkNsaW4gSW5mZWN0IERpczwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFn

ZXM+MTI0Mi01MDwvcGFnZXM+PHZvbHVtZT40MTwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxl

ZGl0aW9uPjIwMDUvMTAvMDY8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8

L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48

a2V5d29yZD5BbGdvcml0aG1zPC9rZXl3b3JkPjxrZXl3b3JkPkFtcGhvdGVyaWNpbiBCLyB0aGVy

YXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWZ1bmdhbCBBZ2VudHMvIHRoZXJhcGV1

dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2Jsb29kL2NvbXBsaWNhdGlv

bnMvZGlhZ25vc2lzL3ByZXZlbnRpb24gJmFtcDsgY29udHJvbDwva2V5d29yZD48a2V5d29yZD5G

ZWFzaWJpbGl0eSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5

d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBEaXNlYXNlcywgRnVuZ2FsL2Jsb29k

L2NvbXBsaWNhdGlvbnMvZGlhZ25vc2lzL3ByZXZlbnRpb24gJmFtcDsgY29udHJvbDwva2V5d29y

ZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvIGJsb29kPC9rZXl3b3Jk

PjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk15Y29zZXMvYmxvb2QvY29t

cGxpY2F0aW9ucy8gZGlhZ25vc2lzLyBwcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+

PGtleXdvcmQ+TmV1dHJvcGVuaWEvIGNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+UHJv

c3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+

PGtleXdvcmQ+VG9tb2dyYXBoeSwgWC1SYXkgQ29tcHV0ZWQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48

ZGF0ZXM+PHllYXI+MjAwNTwveWVhcj48cHViLWRhdGVzPjxkYXRlPk5vdiAxPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00ODM4

IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xNjIwNjA5NzwvYWNjZXNzaW9uLW51bT48

dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwODYvNDk2OTI3PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3Rl

LWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3JyaXNzZXk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy

PjxSZWNOdW0+MjcwPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls4MCwgOTZdPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjI3MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0

YW1wPSIxNDEzODQ4MjQ3Ij4yNzA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPk1vcnJpc3NleSwgQy4gTy48L2F1dGhvcj48YXV0aG9yPkNoZW4sIFMuIEMuPC9hdXRob3I+

PGF1dGhvcj5Tb3JyZWxsLCBULiBDLjwvYXV0aG9yPjxhdXRob3I+TWlsbGlrZW4sIFMuPC9hdXRo

b3I+PGF1dGhvcj5CYXJkeSwgUC4gRy48L2F1dGhvcj48YXV0aG9yPkJyYWRzdG9jaywgSy4gRi48

L2F1dGhvcj48YXV0aG9yPlN6ZXIsIEouPC9hdXRob3I+PGF1dGhvcj5IYWxsaWRheSwgQy4gTC48

L2F1dGhvcj48YXV0aG9yPkdpbHJveSwgTi4gTS48L2F1dGhvcj48YXV0aG9yPk1vb3JlLCBKLjwv

YXV0aG9yPjxhdXRob3I+U2Nod2FyZXIsIEEuIFAuPC9hdXRob3I+PGF1dGhvcj5HdXksIFMuPC9h

dXRob3I+PGF1dGhvcj5CYWplbCwgQS48L2F1dGhvcj48YXV0aG9yPlRyYW1vbnRhbmEsIEEuIFIu

PC9hdXRob3I+PGF1dGhvcj5TcGVsbWFuLCBULjwvYXV0aG9yPjxhdXRob3I+U2xhdmluLCBNLiBB

LjwvYXV0aG9yPjxhdXRob3I+QXVzdHJhbGFzaWFuIExldWthZW1pYSBMeW1waG9tYSwgR3JvdXA8

L2F1dGhvcj48YXV0aG9yPnRoZSwgQXVzdHJhbGlhPC9hdXRob3I+PGF1dGhvcj5OZXcgWmVhbGFu

ZCBNeWNvbG9neSBJbnRlcmVzdCwgR3JvdXA8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5JbmZlY3Rpb3VzIERpc2Vhc2VzIFVuaXQsIEFsZnJlZCBIZWFsdGgs

IGFuZCBEZXBhcnRtZW50IG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIENlbnRyYWwgQ2xpbmljYWwg

U2Nob29sLCBNb25hc2ggVW5pdmVyc2l0eSwgTWVsYm91cm5lLCBWSUMsIEF1c3RyYWxpYS4gby5t

b3JyaXNzZXlAYWxmcmVkLm9yZy5hdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkdhbGFj

dG9tYW5uYW4gYW5kIFBDUiB2ZXJzdXMgY3VsdHVyZSBhbmQgaGlzdG9sb2d5IGZvciBkaXJlY3Rp

bmcgdXNlIG9mIGFudGlmdW5nYWwgdHJlYXRtZW50IGZvciBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lz

IGluIGhpZ2gtcmlzayBoYWVtYXRvbG9neSBwYXRpZW50czogYSByYW5kb21pc2VkIGNvbnRyb2xs

ZWQgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TGFuY2V0IEluZmVjdCBEaXM8L3NlY29u

ZGFyeS10aXRsZT48YWx0LXRpdGxlPlRoZSBMYW5jZXQuIEluZmVjdGlvdXMgZGlzZWFzZXM8L2Fs

dC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5MYW5jZXQgSW5mZWN0aW91

cyBEaXNlYXNlczwvZnVsbC10aXRsZT48YWJici0xPkxhbmNldCBJbmZlY3QuIERpcy48L2FiYnIt

MT48YWJici0yPkxhbmNldCBJbmZlY3QgRGlzPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz41

MTktMjg8L3BhZ2VzPjx2b2x1bWU+MTM8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48a2V5d29y

ZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWZ1bmdhbCBBZ2VudHMvKnRo

ZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2RpYWdub3Npcy8q

ZHJ1ZyB0aGVyYXB5LyptZXRhYm9saXNtL3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5Bc3Bl

cmdpbGx1cy8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbi9wYXRob2dlbmljaXR5PC9rZXl3

b3JkPjxrZXl3b3JkPkJpb2xvZ2ljYWwgTWFya2Vycy9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3

b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwva2V5d29yZD48

a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TGV1a2VtaWEsIEx5bXBob2lkL2RydWcg

dGhlcmFweS8qbWljcm9iaW9sb2d5L3N1cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5

d29yZD48a2V5d29yZD5NYW5uYW5zLyptZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRs

ZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb24vKm1ldGhv

ZHM8L2tleXdvcmQ+PGtleXdvcmQ+U3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbjwva2V5d29yZD48

a2V5d29yZD5UcmFuc3BsYW50YXRpb24sIEhvbW9sb2dvdXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48

ZGF0ZXM+PHllYXI+MjAxMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1k

YXRlcz48L2RhdGVzPjxpc2JuPjE0NzQtNDQ1NyAoRWxlY3Ryb25pYykmI3hEOzE0NzMtMzA5OSAo

TGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjM2Mzk2MTI8L2FjY2Vzc2lvbi1udW0+PHVy

bHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQv

MjM2Mzk2MTI8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjEwLjEwMTYvUzE0NzMtMzA5OSgxMyk3MDA3Ni04PC9lbGVjdHJvbmljLXJlc291cmNlLW51

bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NYWVydGVuczwvQXV0aG9yPjxZZWFyPjIw

MDU8L1llYXI+PFJlY051bT4xMjMzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMjMzPC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2

dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjMzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10

eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1

dGhvcnM+PGF1dGhvcj5NYWVydGVucywgSi48L2F1dGhvcj48YXV0aG9yPlRoZXVuaXNzZW4sIEsu

PC9hdXRob3I+PGF1dGhvcj5WZXJob2VmLCBHLjwvYXV0aG9yPjxhdXRob3I+VmVyc2NoYWtlbGVu

LCBKLjwvYXV0aG9yPjxhdXRob3I+TGFncm91LCBLLjwvYXV0aG9yPjxhdXRob3I+VmVyYmVrZW4s

IEUuPC9hdXRob3I+PGF1dGhvcj5XaWxtZXIsIEEuPC9hdXRob3I+PGF1dGhvcj5WZXJoYWVnZW4s

IEouPC9hdXRob3I+PGF1dGhvcj5Cb29nYWVydHMsIE0uPC9hdXRob3I+PGF1dGhvcj5WYW4gRWxk

ZXJlLCBKLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRl

cGFydG1lbnQgb2YgSGVtYXRvbG9neSwgVW5pdmVyc2l0eSBIb3NwaXRhbCBHYXN0aHVpc2Jlcmcs

IExldXZlbiwgQmVsZ2l1bS4gam9oYW4ubWFlcnRlbnNAdXoua3VsZXV2ZW4uYWMuYmU8L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5HYWxhY3RvbWFubmFuIGFuZCBjb21wdXRlZCB0b21vZ3Jh

cGh5LWJhc2VkIHByZWVtcHRpdmUgYW50aWZ1bmdhbCB0aGVyYXB5IGluIG5ldXRyb3BlbmljIHBh

dGllbnRzIGF0IGhpZ2ggcmlzayBmb3IgaW52YXNpdmUgZnVuZ2FsIGluZmVjdGlvbjogYSBwcm9z

cGVjdGl2ZSBmZWFzaWJpbGl0eSBzdHVkeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluaWNh

bCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5DbGluaWNh

bCBpbmZlY3Rpb3VzIGRpc2Vhc2VzIDogYW4gb2ZmaWNpYWwgcHVibGljYXRpb24gb2YgdGhlIElu

ZmVjdGlvdXMgRGlzZWFzZXMgU29jaWV0eSBvZiBBbWVyaWNhPC9hbHQtdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2xpbmljYWwgSW5mZWN0aW91cyBEaXNlYXNlczwvZnVs

bC10aXRsZT48YWJici0xPkNsaW4gSW5mZWN0IERpczwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFn

ZXM+MTI0Mi01MDwvcGFnZXM+PHZvbHVtZT40MTwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxl

ZGl0aW9uPjIwMDUvMTAvMDY8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8

L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48

a2V5d29yZD5BbGdvcml0aG1zPC9rZXl3b3JkPjxrZXl3b3JkPkFtcGhvdGVyaWNpbiBCLyB0aGVy

YXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWZ1bmdhbCBBZ2VudHMvIHRoZXJhcGV1

dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2Jsb29kL2NvbXBsaWNhdGlv

bnMvZGlhZ25vc2lzL3ByZXZlbnRpb24gJmFtcDsgY29udHJvbDwva2V5d29yZD48a2V5d29yZD5G

ZWFzaWJpbGl0eSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5

d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBEaXNlYXNlcywgRnVuZ2FsL2Jsb29k

L2NvbXBsaWNhdGlvbnMvZGlhZ25vc2lzL3ByZXZlbnRpb24gJmFtcDsgY29udHJvbDwva2V5d29y

ZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvIGJsb29kPC9rZXl3b3Jk

PjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk15Y29zZXMvYmxvb2QvY29t

cGxpY2F0aW9ucy8gZGlhZ25vc2lzLyBwcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+

PGtleXdvcmQ+TmV1dHJvcGVuaWEvIGNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+UHJv

c3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+

PGtleXdvcmQ+VG9tb2dyYXBoeSwgWC1SYXkgQ29tcHV0ZWQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48

ZGF0ZXM+PHllYXI+MjAwNTwveWVhcj48cHViLWRhdGVzPjxkYXRlPk5vdiAxPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1OC00ODM4

IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xNjIwNjA5NzwvYWNjZXNzaW9uLW51bT48

dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwODYvNDk2OTI3PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3Rl

LWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [80, 96]. However, the specific patient population tested is critical to optimizing GM usefulness. GM sensitivity in non-neutropenic patients appears to be lower than in other subgroups PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LdTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJlY051

bT4xMjM1PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls5N108L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJl

Yy1udW1iZXI+MTIzNTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+MTIzNTwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+S3UsIE4uIFMuPC9hdXRob3I+PGF1dGhvcj5I

YW4sIFMuIEguPC9hdXRob3I+PGF1dGhvcj5DaG9pLCBKLiBZLjwvYXV0aG9yPjxhdXRob3I+S2lt

LCBTLiBCLjwvYXV0aG9yPjxhdXRob3I+S2ltLCBILiBXLjwvYXV0aG9yPjxhdXRob3I+SmVvbmcs

IFMuIEouPC9hdXRob3I+PGF1dGhvcj5LaW0sIEMuIE8uPC9hdXRob3I+PGF1dGhvcj5Tb25nLCBZ

LiBHLjwvYXV0aG9yPjxhdXRob3I+S2ltLCBKLiBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUsIFlv

bnNlaSBVbml2ZXJzaXR5IENvbGxlZ2Ugb2YgTWVkaWNpbmUsIFNlb3VsLCBLb3JlYS48L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EaWFnbm9zdGljIHZhbHVlIG9mIHRoZSBzZXJ1bSBnYWxh

Y3RvbWFubmFuIGFzc2F5IGZvciBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzOiBpdCBpcyBsZXNzIHVz

ZWZ1bCBpbiBub24taGFlbWF0b2xvZ2ljYWwgcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+U2NhbmRpbmF2aWFuIEpvdXJuYWwgb2YgSW5mZWN0aW91cyBEaXNlYXNlczwvc2Vjb25kYXJ5

LXRpdGxlPjxhbHQtdGl0bGU+U2NhbmRpbmF2aWFuIGpvdXJuYWwgb2YgaW5mZWN0aW91cyBkaXNl

YXNlczwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlNjYW5kaW5h

dmlhbiBKb3VybmFsIG9mIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5T

Y2FuZCBKIEluZmVjdCBEaXM8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPlNjYW5kaW5hdmlhbiBKb3VybmFsIG9mIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1

bGwtdGl0bGU+PGFiYnItMT5TY2FuZCBKIEluZmVjdCBEaXM8L2FiYnItMT48L2FsdC1wZXJpb2Rp

Y2FsPjxwYWdlcz42MDAtNDwvcGFnZXM+PHZvbHVtZT40NDwvdm9sdW1lPjxudW1iZXI+ODwvbnVt

YmVyPjxlZGl0aW9uPjIwMTIvMDMvMDY8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xl

c2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5

d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5Bc3Blcmdp

bGxvc2lzLyBibG9vZC9kaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9lbnp5bWUgVGVjaG5pcXVl

cy9tZXRob2RzL3N0YW5kYXJkczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3

b3JkPk1hbm5hbnMvIGJsb29kPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3Jk

PjxrZXl3b3JkPlByZWRpY3RpdmUgVmFsdWUgb2YgVGVzdHM8L2tleXdvcmQ+PGtleXdvcmQ+UmV0

cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVj

aWZpY2l0eTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjxwdWIt

ZGF0ZXM+PGRhdGU+QXVnPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTY1MS0xOTgw

IChFbGVjdHJvbmljKSYjeEQ7MDAzNi01NTQ4IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51

bT4yMjM4NTI3MDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3Vy

Y2UtbnVtPjEwLjMxMDkvMDAzNjU1NDguMjAxMi42NTc2NzI8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlk

ZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LdTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJlY051

bT4xMjM1PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls5N108L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJl

Yy1udW1iZXI+MTIzNTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+MTIzNTwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+S3UsIE4uIFMuPC9hdXRob3I+PGF1dGhvcj5I

YW4sIFMuIEguPC9hdXRob3I+PGF1dGhvcj5DaG9pLCBKLiBZLjwvYXV0aG9yPjxhdXRob3I+S2lt

LCBTLiBCLjwvYXV0aG9yPjxhdXRob3I+S2ltLCBILiBXLjwvYXV0aG9yPjxhdXRob3I+SmVvbmcs

IFMuIEouPC9hdXRob3I+PGF1dGhvcj5LaW0sIEMuIE8uPC9hdXRob3I+PGF1dGhvcj5Tb25nLCBZ

LiBHLjwvYXV0aG9yPjxhdXRob3I+S2ltLCBKLiBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUsIFlv

bnNlaSBVbml2ZXJzaXR5IENvbGxlZ2Ugb2YgTWVkaWNpbmUsIFNlb3VsLCBLb3JlYS48L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EaWFnbm9zdGljIHZhbHVlIG9mIHRoZSBzZXJ1bSBnYWxh

Y3RvbWFubmFuIGFzc2F5IGZvciBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzOiBpdCBpcyBsZXNzIHVz

ZWZ1bCBpbiBub24taGFlbWF0b2xvZ2ljYWwgcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+U2NhbmRpbmF2aWFuIEpvdXJuYWwgb2YgSW5mZWN0aW91cyBEaXNlYXNlczwvc2Vjb25kYXJ5

LXRpdGxlPjxhbHQtdGl0bGU+U2NhbmRpbmF2aWFuIGpvdXJuYWwgb2YgaW5mZWN0aW91cyBkaXNl

YXNlczwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlNjYW5kaW5h

dmlhbiBKb3VybmFsIG9mIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5T

Y2FuZCBKIEluZmVjdCBEaXM8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPlNjYW5kaW5hdmlhbiBKb3VybmFsIG9mIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1

bGwtdGl0bGU+PGFiYnItMT5TY2FuZCBKIEluZmVjdCBEaXM8L2FiYnItMT48L2FsdC1wZXJpb2Rp

Y2FsPjxwYWdlcz42MDAtNDwvcGFnZXM+PHZvbHVtZT40NDwvdm9sdW1lPjxudW1iZXI+ODwvbnVt

YmVyPjxlZGl0aW9uPjIwMTIvMDMvMDY8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xl

c2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5

d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5Bc3Blcmdp

bGxvc2lzLyBibG9vZC9kaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9lbnp5bWUgVGVjaG5pcXVl

cy9tZXRob2RzL3N0YW5kYXJkczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3

b3JkPk1hbm5hbnMvIGJsb29kPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3Jk

PjxrZXl3b3JkPlByZWRpY3RpdmUgVmFsdWUgb2YgVGVzdHM8L2tleXdvcmQ+PGtleXdvcmQ+UmV0

cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVj

aWZpY2l0eTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjxwdWIt

ZGF0ZXM+PGRhdGU+QXVnPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTY1MS0xOTgw

IChFbGVjdHJvbmljKSYjeEQ7MDAzNi01NTQ4IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51

bT4yMjM4NTI3MDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3Vy

Y2UtbnVtPjEwLjMxMDkvMDAzNjU1NDguMjAxMi42NTc2NzI8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlk

ZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA [97], and decreases to approximately 20% in solid organ transplant recipients PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Gb3J0dW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

ZWNOdW0+MTIzNjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bOTgtMTAwXTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4xMjM2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjM2PC9r

ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl

Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Gb3J0dW4sIEouPC9hdXRob3I+

PGF1dGhvcj5NYXJ0aW4tRGF2aWxhLCBQLjwvYXV0aG9yPjxhdXRob3I+QWx2YXJleiwgTS4gRS48

L2F1dGhvcj48YXV0aG9yPk5vcm1hbiwgRi48L2F1dGhvcj48YXV0aG9yPlNhbmNoZXotU291c2Es

IEEuPC9hdXRob3I+PGF1dGhvcj5HYWphdGUsIEwuPC9hdXRob3I+PGF1dGhvcj5CYXJjZW5hLCBS

LjwvYXV0aG9yPjxhdXRob3I+TnVubywgUy4gSi48L2F1dGhvcj48YXV0aG9yPk1vcmVubywgUy48

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50

IG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIEhvc3BpdGFsIFJhbW9uIHkgQ2FqYWwsIE1hZHJpZCwg

U3BhaW4uIGZvcnR1bmFiZXRlQGdtYWlsLmNvbTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PkZhbHNlLXBvc2l0aXZlIHJlc3VsdHMgb2YgQXNwZXJnaWxsdXMgZ2FsYWN0b21hbm5hbiBhbnRp

Z2VuZW1pYSBpbiBsaXZlciB0cmFuc3BsYW50IHJlY2lwaWVudHM8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+VHJhbnNwbGFudGF0aW9uPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5UcmFuc3Bs

YW50YXRpb248L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5UcmFu

c3BsYW50YXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5UcmFuc3BsYW50YXRpb248L2FiYnItMT48

L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlRyYW5zcGxhbnRhdGlvbjwv

ZnVsbC10aXRsZT48YWJici0xPlRyYW5zcGxhbnRhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGlj

YWw+PHBhZ2VzPjI1Ni02MDwvcGFnZXM+PHZvbHVtZT44Nzwvdm9sdW1lPjxudW1iZXI+MjwvbnVt

YmVyPjxlZGl0aW9uPjIwMDkvMDEvMjI8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFtcGlj

aWxsaW4vY2hlbWlzdHJ5PC9rZXl3b3JkPjxrZXl3b3JkPkFudGktQmFjdGVyaWFsIEFnZW50cy9j

aGVtaXN0cnk8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWdlbnMsIEZ1bmdhbC8gYmxvb2Q8L2tleXdv

cmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8gZGlhZ25vc2lzL2V0aW9sb2d5L2ltbXVub2xvZ3k8

L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvIGltbXVub2xvZ3k8L2tleXdvcmQ+PGtleXdv

cmQ+RHJ1ZyBDb250YW1pbmF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkVuenltZS1MaW5rZWQgSW1t

dW5vc29yYmVudCBBc3NheTwva2V5d29yZD48a2V5d29yZD5GYWxzZSBQb3NpdGl2ZSBSZWFjdGlv

bnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkxpdmVyIFRyYW5z

cGxhbnRhdGlvbi8gYWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvYW5h

bHlzaXMvIGJsb29kPC9rZXl3b3JkPjxrZXl3b3JkPlByZWRpY3RpdmUgVmFsdWUgb2YgVGVzdHM8

L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5U

aW1lIEZhY3RvcnM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48

cHViLWRhdGVzPjxkYXRlPkphbiAyNzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1

MzQtNjA4MCAoRWxlY3Ryb25pYykmI3hEOzAwNDEtMTMzNyAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MTkxNTU5ODE8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT4xMC4xMDk3L1RQLjBiMDEzZTMxODE5Mjg4ZDU8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2Ut

cHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB

dXRob3I+S3dhazwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJlY051bT4xMjM3PC9SZWNOdW0+

PHJlY29yZD48cmVjLW51bWJlcj4xMjM3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjM3

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Ld2FrLCBFLiBKLjwvYXV0

aG9yPjxhdXRob3I+SHVzYWluLCBTLjwvYXV0aG9yPjxhdXRob3I+T2JtYW4sIEEuPC9hdXRob3I+

PGF1dGhvcj5NZWlua2UsIEwuPC9hdXRob3I+PGF1dGhvcj5TdG91dCwgSi48L2F1dGhvcj48YXV0

aG9yPkt1c25lLCBTLjwvYXV0aG9yPjxhdXRob3I+V2FnZW5lciwgTS4gTS48L2F1dGhvcj48YXV0

aG9yPlNpbmdoLCBOLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPlRob21hcyBFIFN0YXJ6bCBUcmFuc3BsYW50YXRpb24gSW5zdGl0dXRlLCBVbml2ZXJzaXR5

IG9mIFBpdHRzYnVyZ2ggTWVkaWNhbCBDZW50ZXIsIFBpdHRzYnVyZ2gsIFBlbm5zeWx2YW5pYSAx

NTI0MCwgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmljYWN5IG9mIGdhbGFj

dG9tYW5uYW4gYW50aWdlbiBpbiB0aGUgUGxhdGVsaWEgQXNwZXJnaWxsdXMgZW56eW1lIGltbXVu

b2Fzc2F5IGZvciBkaWFnbm9zaXMgb2YgaW52YXNpdmUgYXNwZXJnaWxsb3NpcyBpbiBsaXZlciB0

cmFuc3BsYW50IHJlY2lwaWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiBD

bGluaWNhbCBNaWNyb2Jpb2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkpvdXJuYWwg

b2YgY2xpbmljYWwgbWljcm9iaW9sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3k8L2Z1bGwtdGl0bGU+

PGFiYnItMT5KIENsaW4gTWljcm9iaW9sPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE1pY3JvYmlvbG9neTwvZnVsbC10

aXRsZT48YWJici0xPkogQ2xpbiBNaWNyb2Jpb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxw

YWdlcz40MzUtODwvcGFnZXM+PHZvbHVtZT40Mjwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxl

ZGl0aW9uPjIwMDQvMDEvMTM8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3

b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8gZGlhZ25v

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+SW1tdW5vZW56eW1lIFRlY2huaXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+

TGl2ZXIgVHJhbnNwbGFudGF0aW9uLyBhZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+

TWFsZTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5zLyBhbmFseXNpczwva2V5d29yZD48a2V5d29y

ZD5NaWRkbGUgQWdlZDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA0PC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+SmFuPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDA5

NS0xMTM3IChQcmludCkmI3hEOzAwOTUtMTEzNyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+MTQ3MTU3OTk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxjdXN0b20yPjMyMTcxODwv

Y3VzdG9tMj48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXBy

b3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0

aG9yPkh1c2FpbjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJlY051bT44MTA8L1JlY051bT48

cmVjb3JkPjxyZWMtbnVtYmVyPjgxMDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0

YW1wPSIxNDU0MzcyMzEwIj44MTA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPkh1c2FpbiwgUy48L2F1dGhvcj48YXV0aG9yPkt3YWssIEUuIEouPC9hdXRob3I+PGF1dGhv

cj5PYm1hbiwgQS48L2F1dGhvcj48YXV0aG9yPldhZ2VuZXIsIE0uIE0uPC9hdXRob3I+PGF1dGhv

cj5LdXNuZSwgUy48L2F1dGhvcj48YXV0aG9yPlN0b3V0LCBKLiBFLjwvYXV0aG9yPjxhdXRob3I+

TWNDdXJyeSwgSy4gUi48L2F1dGhvcj48YXV0aG9yPlNpbmdoLCBOLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlVuaXZlcnNpdHkgb2YgUGl0dHNidXJnaCBN

ZWRpY2FsIENlbnRlciwgVGhvbWFzIEUuIFN0YXJ6bCBUcmFuc3BsYW50YXRpb24gSW5zdGl0dXRl

LCBQaXR0c2J1cmdoLCBQQSwgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlByb3Nw

ZWN0aXZlIGFzc2Vzc21lbnQgb2YgUGxhdGVsaWEgQXNwZXJnaWxsdXMgZ2FsYWN0b21hbm5hbiBh

bnRpZ2VuIGZvciB0aGUgZGlhZ25vc2lzIG9mIGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgaW4gbHVu

ZyB0cmFuc3BsYW50IHJlY2lwaWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW0gSiBUcmFu

c3BsYW50PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

QW1lcmljYW4gSm91cm5hbCBvZiBUcmFuc3BsYW50YXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5B

bS4gSi4gVHJhbnNwbGFudC48L2FiYnItMT48YWJici0yPkFtIEogVHJhbnNwbGFudDwvYWJici0y

PjwvcGVyaW9kaWNhbD48cGFnZXM+Nzk2LTgwMjwvcGFnZXM+PHZvbHVtZT40PC92b2x1bWU+PG51

bWJlcj41PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWdlbnMvaW1tdW5vbG9neTwva2V5d29yZD48a2V5

d29yZD5Bc3BlcmdpbGxvc2lzLypkaWFnbm9zaXMvbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3Jk

PkFzcGVyZ2lsbHVzLyppbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkZhbHNlIFBvc2l0aXZl

IFJlYWN0aW9uczwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPipJbW11bm9lbnp5bWUgVGVjaG5pcXVlczwva2V5d29yZD48

a2V5d29yZD5MdW5nLyptaWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBUcmFuc3Bs

YW50YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD4qTWFubmFu

cy9pbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjwva2V5

d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXk8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNjAwLTYxMzUgKFByaW50KSYjeEQ7MTYwMC02MTM1

IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xNTA4NDE3NzwvYWNjZXNzaW9uLW51bT48

dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1l

ZC8xNTA4NDE3NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJj

ZS1udW0+MTAuMTExMS9qLjE2MDAtNjE0My4yMDA0LjAwNDE1Lng8L2VsZWN0cm9uaWMtcmVzb3Vy

Y2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Gb3J0dW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

ZWNOdW0+MTIzNjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bOTgtMTAwXTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4xMjM2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjM2PC9r

ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl

Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Gb3J0dW4sIEouPC9hdXRob3I+

PGF1dGhvcj5NYXJ0aW4tRGF2aWxhLCBQLjwvYXV0aG9yPjxhdXRob3I+QWx2YXJleiwgTS4gRS48

L2F1dGhvcj48YXV0aG9yPk5vcm1hbiwgRi48L2F1dGhvcj48YXV0aG9yPlNhbmNoZXotU291c2Es

IEEuPC9hdXRob3I+PGF1dGhvcj5HYWphdGUsIEwuPC9hdXRob3I+PGF1dGhvcj5CYXJjZW5hLCBS

LjwvYXV0aG9yPjxhdXRob3I+TnVubywgUy4gSi48L2F1dGhvcj48YXV0aG9yPk1vcmVubywgUy48

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50

IG9mIEluZmVjdGlvdXMgRGlzZWFzZXMsIEhvc3BpdGFsIFJhbW9uIHkgQ2FqYWwsIE1hZHJpZCwg

U3BhaW4uIGZvcnR1bmFiZXRlQGdtYWlsLmNvbTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PkZhbHNlLXBvc2l0aXZlIHJlc3VsdHMgb2YgQXNwZXJnaWxsdXMgZ2FsYWN0b21hbm5hbiBhbnRp

Z2VuZW1pYSBpbiBsaXZlciB0cmFuc3BsYW50IHJlY2lwaWVudHM8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+VHJhbnNwbGFudGF0aW9uPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5UcmFuc3Bs

YW50YXRpb248L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5UcmFu

c3BsYW50YXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5UcmFuc3BsYW50YXRpb248L2FiYnItMT48

L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlRyYW5zcGxhbnRhdGlvbjwv

ZnVsbC10aXRsZT48YWJici0xPlRyYW5zcGxhbnRhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGlj

YWw+PHBhZ2VzPjI1Ni02MDwvcGFnZXM+PHZvbHVtZT44Nzwvdm9sdW1lPjxudW1iZXI+MjwvbnVt

YmVyPjxlZGl0aW9uPjIwMDkvMDEvMjI8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFtcGlj

aWxsaW4vY2hlbWlzdHJ5PC9rZXl3b3JkPjxrZXl3b3JkPkFudGktQmFjdGVyaWFsIEFnZW50cy9j

aGVtaXN0cnk8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWdlbnMsIEZ1bmdhbC8gYmxvb2Q8L2tleXdv

cmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8gZGlhZ25vc2lzL2V0aW9sb2d5L2ltbXVub2xvZ3k8

L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvIGltbXVub2xvZ3k8L2tleXdvcmQ+PGtleXdv

cmQ+RHJ1ZyBDb250YW1pbmF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkVuenltZS1MaW5rZWQgSW1t

dW5vc29yYmVudCBBc3NheTwva2V5d29yZD48a2V5d29yZD5GYWxzZSBQb3NpdGl2ZSBSZWFjdGlv

bnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkxpdmVyIFRyYW5z

cGxhbnRhdGlvbi8gYWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvYW5h

bHlzaXMvIGJsb29kPC9rZXl3b3JkPjxrZXl3b3JkPlByZWRpY3RpdmUgVmFsdWUgb2YgVGVzdHM8

L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5U

aW1lIEZhY3RvcnM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48

cHViLWRhdGVzPjxkYXRlPkphbiAyNzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1

MzQtNjA4MCAoRWxlY3Ryb25pYykmI3hEOzAwNDEtMTMzNyAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MTkxNTU5ODE8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT4xMC4xMDk3L1RQLjBiMDEzZTMxODE5Mjg4ZDU8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2Ut

cHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB

dXRob3I+S3dhazwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJlY051bT4xMjM3PC9SZWNOdW0+

PHJlY29yZD48cmVjLW51bWJlcj4xMjM3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjM3

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Ld2FrLCBFLiBKLjwvYXV0

aG9yPjxhdXRob3I+SHVzYWluLCBTLjwvYXV0aG9yPjxhdXRob3I+T2JtYW4sIEEuPC9hdXRob3I+

PGF1dGhvcj5NZWlua2UsIEwuPC9hdXRob3I+PGF1dGhvcj5TdG91dCwgSi48L2F1dGhvcj48YXV0

aG9yPkt1c25lLCBTLjwvYXV0aG9yPjxhdXRob3I+V2FnZW5lciwgTS4gTS48L2F1dGhvcj48YXV0

aG9yPlNpbmdoLCBOLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPlRob21hcyBFIFN0YXJ6bCBUcmFuc3BsYW50YXRpb24gSW5zdGl0dXRlLCBVbml2ZXJzaXR5

IG9mIFBpdHRzYnVyZ2ggTWVkaWNhbCBDZW50ZXIsIFBpdHRzYnVyZ2gsIFBlbm5zeWx2YW5pYSAx

NTI0MCwgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmljYWN5IG9mIGdhbGFj

dG9tYW5uYW4gYW50aWdlbiBpbiB0aGUgUGxhdGVsaWEgQXNwZXJnaWxsdXMgZW56eW1lIGltbXVu

b2Fzc2F5IGZvciBkaWFnbm9zaXMgb2YgaW52YXNpdmUgYXNwZXJnaWxsb3NpcyBpbiBsaXZlciB0

cmFuc3BsYW50IHJlY2lwaWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiBD

bGluaWNhbCBNaWNyb2Jpb2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkpvdXJuYWwg

b2YgY2xpbmljYWwgbWljcm9iaW9sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3k8L2Z1bGwtdGl0bGU+

PGFiYnItMT5KIENsaW4gTWljcm9iaW9sPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE1pY3JvYmlvbG9neTwvZnVsbC10

aXRsZT48YWJici0xPkogQ2xpbiBNaWNyb2Jpb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxw

YWdlcz40MzUtODwvcGFnZXM+PHZvbHVtZT40Mjwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxl

ZGl0aW9uPjIwMDQvMDEvMTM8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3

b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8gZGlhZ25v

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+SW1tdW5vZW56eW1lIFRlY2huaXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+

TGl2ZXIgVHJhbnNwbGFudGF0aW9uLyBhZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+

TWFsZTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5zLyBhbmFseXNpczwva2V5d29yZD48a2V5d29y

ZD5NaWRkbGUgQWdlZDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA0PC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+SmFuPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDA5

NS0xMTM3IChQcmludCkmI3hEOzAwOTUtMTEzNyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+MTQ3MTU3OTk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxjdXN0b20yPjMyMTcxODwv

Y3VzdG9tMj48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXBy

b3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0

aG9yPkh1c2FpbjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJlY051bT44MTA8L1JlY051bT48

cmVjb3JkPjxyZWMtbnVtYmVyPjgxMDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0

YW1wPSIxNDU0MzcyMzEwIj44MTA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPkh1c2FpbiwgUy48L2F1dGhvcj48YXV0aG9yPkt3YWssIEUuIEouPC9hdXRob3I+PGF1dGhv

cj5PYm1hbiwgQS48L2F1dGhvcj48YXV0aG9yPldhZ2VuZXIsIE0uIE0uPC9hdXRob3I+PGF1dGhv

cj5LdXNuZSwgUy48L2F1dGhvcj48YXV0aG9yPlN0b3V0LCBKLiBFLjwvYXV0aG9yPjxhdXRob3I+

TWNDdXJyeSwgSy4gUi48L2F1dGhvcj48YXV0aG9yPlNpbmdoLCBOLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlVuaXZlcnNpdHkgb2YgUGl0dHNidXJnaCBN

ZWRpY2FsIENlbnRlciwgVGhvbWFzIEUuIFN0YXJ6bCBUcmFuc3BsYW50YXRpb24gSW5zdGl0dXRl

LCBQaXR0c2J1cmdoLCBQQSwgVVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlByb3Nw

ZWN0aXZlIGFzc2Vzc21lbnQgb2YgUGxhdGVsaWEgQXNwZXJnaWxsdXMgZ2FsYWN0b21hbm5hbiBh

bnRpZ2VuIGZvciB0aGUgZGlhZ25vc2lzIG9mIGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgaW4gbHVu

ZyB0cmFuc3BsYW50IHJlY2lwaWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW0gSiBUcmFu

c3BsYW50PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

QW1lcmljYW4gSm91cm5hbCBvZiBUcmFuc3BsYW50YXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5B

bS4gSi4gVHJhbnNwbGFudC48L2FiYnItMT48YWJici0yPkFtIEogVHJhbnNwbGFudDwvYWJici0y

PjwvcGVyaW9kaWNhbD48cGFnZXM+Nzk2LTgwMjwvcGFnZXM+PHZvbHVtZT40PC92b2x1bWU+PG51

bWJlcj41PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWdlbnMvaW1tdW5vbG9neTwva2V5d29yZD48a2V5

d29yZD5Bc3BlcmdpbGxvc2lzLypkaWFnbm9zaXMvbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3Jk

PkFzcGVyZ2lsbHVzLyppbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkZhbHNlIFBvc2l0aXZl

IFJlYWN0aW9uczwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPipJbW11bm9lbnp5bWUgVGVjaG5pcXVlczwva2V5d29yZD48

a2V5d29yZD5MdW5nLyptaWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBUcmFuc3Bs

YW50YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD4qTWFubmFu

cy9pbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjwva2V5

d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXk8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNjAwLTYxMzUgKFByaW50KSYjeEQ7MTYwMC02MTM1

IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xNTA4NDE3NzwvYWNjZXNzaW9uLW51bT48

dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1l

ZC8xNTA4NDE3NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJj

ZS1udW0+MTAuMTExMS9qLjE2MDAtNjE0My4yMDA0LjAwNDE1Lng8L2VsZWN0cm9uaWMtcmVzb3Vy

Y2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [98-100]. The GM assay has been repeatedly negative in patients with CGD and IA PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WZXJ3ZWlqPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48

UmVjTnVtPjQyMDwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTAxLCAxMDJdPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjQyMDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+NDIwPC9r

ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl

Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5WZXJ3ZWlqLCBQIEU8L2F1dGhv

cj48YXV0aG9yPldlZW1hZXMsIEMgTTwvYXV0aG9yPjxhdXRob3I+Q3VyZnMsIEogSCBBIEo8L2F1

dGhvcj48YXV0aG9yPkJyZXRhZ25lLCBTPC9hdXRob3I+PGF1dGhvcj5NZWlzLCBKIEYgRyBNPC9h

dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPjxzdHlsZSBmYWNl

PSJub3JtYWwiIGZvbnQ9ImRlZmF1bHQiIHNpemU9IjEwMCUiPkZhaWx1cmUgdG8gZGV0ZWN0IGNp

cmN1bGF0aW5nIDwvc3R5bGU+PHN0eWxlIGZhY2U9Iml0YWxpYyIgZm9udD0iZGVmYXVsdCIgc2l6

ZT0iMTAwJSI+QXNwZXJnaWxsdXMgPC9zdHlsZT48c3R5bGUgZmFjZT0ibm9ybWFsIiBmb250PSJk

ZWZhdWx0IiBzaXplPSIxMDAlIj5tYXJrZXJzIGluIGEgcGF0aWVudCB3aXRoIGNocm9uaWMgZ3Jh

bnVsb21hdG91cyBkaXNlYXNlIGFuZCBpbnZhc3ZlIGFzcGVyZ2lsbG9zaXM8L3N0eWxlPjwvdGl0

bGU+PHNlY29uZGFyeS10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE1pY3JvYmlvbG9neTwvc2Vj

b25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2Yg

Q2xpbmljYWwgTWljcm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBDbGluIE1pY3JvYmlv

bDwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+MzkwMC0zOTAxPC9wYWdlcz48dm9sdW1lPjM4

PC92b2x1bWU+PGRhdGVzPjx5ZWFyPjIwMDA8L3llYXI+PC9kYXRlcz48dXJscz48L3VybHM+PC9y

ZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TW9ydGVuc2VuPC9BdXRob3I+PFllYXI+MjAxMTwv

WWVhcj48UmVjTnVtPjEyMzg8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEyMzg8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0

ZHRqNWR0ZHJwdzA1ZmZzZndyZXgiPjEyMzg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUg

bmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9y

cz48YXV0aG9yPk1vcnRlbnNlbiwgSy4gTC48L2F1dGhvcj48YXV0aG9yPktudWRzZW4sIEouIEIu

PC9hdXRob3I+PGF1dGhvcj5KZW5zZW4tRmFuZ2VsLCBTLjwvYXV0aG9yPjxhdXRob3I+U3RhdXNi

b2wtR3JvbiwgQi48L2F1dGhvcj48YXV0aG9yPkFyZW5kcnVwLCBNLiBDLjwvYXV0aG9yPjxhdXRo

b3I+UGV0ZXJzZW4sIEUuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+

PHRpdGxlPlN1Y2Nlc3NmdWwgbWFuYWdlbWVudCBvZiBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIHBy

ZXNlbnRpbmcgYXMgcGVyaWNhcmRpdGlzIGluIGFuIGFkdWx0IHBhdGllbnQgd2l0aCBjaHJvbmlj

IGdyYW51bG9tYXRvdXMgZGlzZWFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5NeWNvc2VzPC9z

ZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5NeWNvc2VzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+TXljb3NlczwvZnVsbC10aXRsZT48YWJici0xPk15Y29zZXM8

L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk15Y29zZXM8

L2Z1bGwtdGl0bGU+PGFiYnItMT5NeWNvc2VzPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFn

ZXM+ZTIzMy02PC9wYWdlcz48dm9sdW1lPjU0PC92b2x1bWU+PG51bWJlcj40PC9udW1iZXI+PGVk

aXRpb24+MjAxMC8wMS8wMTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdv

cmQ+PGtleXdvcmQ+QW50aWZ1bmdhbCBBZ2VudHMvYWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdl

PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzL2lzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRp

b248L2tleXdvcmQ+PGtleXdvcmQ+RHJ1ZyBUaGVyYXB5LCBDb21iaW5hdGlvbi9tZXRob2RzPC9r

ZXl3b3JkPjxrZXl3b3JkPkVjaG9jYXJkaW9ncmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxl

PC9rZXl3b3JkPjxrZXl3b3JkPkdyYW51bG9tYXRvdXMgRGlzZWFzZSwgQ2hyb25pYy8gY29tcGxp

Y2F0aW9ucy8gcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5

d29yZD5JbnZhc2l2ZSBQdWxtb25hcnkgQXNwZXJnaWxsb3Npcy8gZGlhZ25vc2lzL21pY3JvYmlv

bG9neS8gcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPk1hZ25ldGljIFJlc29uYW5jZSBJbWFn

aW5nPC9rZXl3b3JkPjxrZXl3b3JkPlBlcmljYXJkaXRpcy8gZGlhZ25vc2lzL21pY3JvYmlvbG9n

eS8gcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJhZGlvZ3JhcGh5LCBUaG9yYWNpYzwva2V5

d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDExPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHViLWRhdGVz

PjwvZGF0ZXM+PGlzYm4+MTQzOS0wNTA3IChFbGVjdHJvbmljKSYjeEQ7MDkzMy03NDA3IChMaW5r

aW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMDA0MTk5NTwvYWNjZXNzaW9uLW51bT48dXJscz48

L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMTEvai4xNDM5LTA1MDcuMjAwOS4w

MTgzNS54PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVy

Pk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WZXJ3ZWlqPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48

UmVjTnVtPjQyMDwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTAxLCAxMDJdPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjQyMDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+NDIwPC9r

ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl

Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5WZXJ3ZWlqLCBQIEU8L2F1dGhv

cj48YXV0aG9yPldlZW1hZXMsIEMgTTwvYXV0aG9yPjxhdXRob3I+Q3VyZnMsIEogSCBBIEo8L2F1

dGhvcj48YXV0aG9yPkJyZXRhZ25lLCBTPC9hdXRob3I+PGF1dGhvcj5NZWlzLCBKIEYgRyBNPC9h

dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPjxzdHlsZSBmYWNl

PSJub3JtYWwiIGZvbnQ9ImRlZmF1bHQiIHNpemU9IjEwMCUiPkZhaWx1cmUgdG8gZGV0ZWN0IGNp

cmN1bGF0aW5nIDwvc3R5bGU+PHN0eWxlIGZhY2U9Iml0YWxpYyIgZm9udD0iZGVmYXVsdCIgc2l6

ZT0iMTAwJSI+QXNwZXJnaWxsdXMgPC9zdHlsZT48c3R5bGUgZmFjZT0ibm9ybWFsIiBmb250PSJk

ZWZhdWx0IiBzaXplPSIxMDAlIj5tYXJrZXJzIGluIGEgcGF0aWVudCB3aXRoIGNocm9uaWMgZ3Jh

bnVsb21hdG91cyBkaXNlYXNlIGFuZCBpbnZhc3ZlIGFzcGVyZ2lsbG9zaXM8L3N0eWxlPjwvdGl0

bGU+PHNlY29uZGFyeS10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE1pY3JvYmlvbG9neTwvc2Vj

b25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2Yg

Q2xpbmljYWwgTWljcm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBDbGluIE1pY3JvYmlv

bDwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+MzkwMC0zOTAxPC9wYWdlcz48dm9sdW1lPjM4

PC92b2x1bWU+PGRhdGVzPjx5ZWFyPjIwMDA8L3llYXI+PC9kYXRlcz48dXJscz48L3VybHM+PC9y

ZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TW9ydGVuc2VuPC9BdXRob3I+PFllYXI+MjAxMTwv

WWVhcj48UmVjTnVtPjEyMzg8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEyMzg8L3JlYy1u

dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0

ZHRqNWR0ZHJwdzA1ZmZzZndyZXgiPjEyMzg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUg

bmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9y

cz48YXV0aG9yPk1vcnRlbnNlbiwgSy4gTC48L2F1dGhvcj48YXV0aG9yPktudWRzZW4sIEouIEIu

PC9hdXRob3I+PGF1dGhvcj5KZW5zZW4tRmFuZ2VsLCBTLjwvYXV0aG9yPjxhdXRob3I+U3RhdXNi

b2wtR3JvbiwgQi48L2F1dGhvcj48YXV0aG9yPkFyZW5kcnVwLCBNLiBDLjwvYXV0aG9yPjxhdXRo

b3I+UGV0ZXJzZW4sIEUuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+

PHRpdGxlPlN1Y2Nlc3NmdWwgbWFuYWdlbWVudCBvZiBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIHBy

ZXNlbnRpbmcgYXMgcGVyaWNhcmRpdGlzIGluIGFuIGFkdWx0IHBhdGllbnQgd2l0aCBjaHJvbmlj

IGdyYW51bG9tYXRvdXMgZGlzZWFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5NeWNvc2VzPC9z

ZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5NeWNvc2VzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+TXljb3NlczwvZnVsbC10aXRsZT48YWJici0xPk15Y29zZXM8

L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk15Y29zZXM8

L2Z1bGwtdGl0bGU+PGFiYnItMT5NeWNvc2VzPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFn

ZXM+ZTIzMy02PC9wYWdlcz48dm9sdW1lPjU0PC92b2x1bWU+PG51bWJlcj40PC9udW1iZXI+PGVk

aXRpb24+MjAxMC8wMS8wMTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdv

cmQ+PGtleXdvcmQ+QW50aWZ1bmdhbCBBZ2VudHMvYWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdl

PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzL2lzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRp

b248L2tleXdvcmQ+PGtleXdvcmQ+RHJ1ZyBUaGVyYXB5LCBDb21iaW5hdGlvbi9tZXRob2RzPC9r

ZXl3b3JkPjxrZXl3b3JkPkVjaG9jYXJkaW9ncmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxl

PC9rZXl3b3JkPjxrZXl3b3JkPkdyYW51bG9tYXRvdXMgRGlzZWFzZSwgQ2hyb25pYy8gY29tcGxp

Y2F0aW9ucy8gcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5

d29yZD5JbnZhc2l2ZSBQdWxtb25hcnkgQXNwZXJnaWxsb3Npcy8gZGlhZ25vc2lzL21pY3JvYmlv

bG9neS8gcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPk1hZ25ldGljIFJlc29uYW5jZSBJbWFn

aW5nPC9rZXl3b3JkPjxrZXl3b3JkPlBlcmljYXJkaXRpcy8gZGlhZ25vc2lzL21pY3JvYmlvbG9n

eS8gcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJhZGlvZ3JhcGh5LCBUaG9yYWNpYzwva2V5

d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDExPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHViLWRhdGVz

PjwvZGF0ZXM+PGlzYm4+MTQzOS0wNTA3IChFbGVjdHJvbmljKSYjeEQ7MDkzMy03NDA3IChMaW5r

aW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMDA0MTk5NTwvYWNjZXNzaW9uLW51bT48dXJscz48

L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMTEvai4xNDM5LTA1MDcuMjAwOS4w

MTgzNS54PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVy

Pk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [101, 102], potentially due to a lack of angioinvasion or immune complex formation with high levels of Aspergillus antibodies. Similarly, serum GM has also been reported to be higher in patients with angioinvasive IA versus non-invasive airway IA PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IaWRhbGdvPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48

UmVjTnVtPjEyMzk8L1JlY051bT48RGlzcGxheVRleHQ+WzEwM108L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MTIzOTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+MTIzOTwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+SGlkYWxnbywgQS48L2F1dGhvcj48

YXV0aG9yPlBhcm9keSwgUi48L2F1dGhvcj48YXV0aG9yPk1hcnRpbm8sIFIuPC9hdXRob3I+PGF1

dGhvcj5TYW5jaGV6LCBGLjwvYXV0aG9yPjxhdXRob3I+RnJhbnF1ZXQsIFQuPC9hdXRob3I+PGF1

dGhvcj5HaW1lbmV6LCBBLjwvYXV0aG9yPjxhdXRob3I+QmxhbmNhcywgQy48L2F1dGhvcj48L2F1

dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFJhZGlvbG9n

eSwgSG9zcGl0YWwgZGUgU2FudCBQYXUsIFVuaXZlcnNpZGFkIEF1dG9ub21hIGRlIEJhcmNlbG9u

YSwgQmFyY2Vsb25hLCBTcGFpbi4gYWxoaWRhbGdvcEB5YWhvby5lczwvYXV0aC1hZGRyZXNzPjx0

aXRsZXM+PHRpdGxlPkNvcnJlbGF0aW9uIGJldHdlZW4gaGlnaC1yZXNvbHV0aW9uIGNvbXB1dGVk

IHRvbW9ncmFwaHkgYW5kIGdhbGFjdG9tYW5uYW4gYW50aWdlbmVtaWEgaW4gYWR1bHQgaGVtYXRv

bG9naWMgcGF0aWVudHMgYXQgcmlzayBmb3IgaW52YXNpdmUgYXNwZXJnaWxsb3NpczwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5FdXIgSiBSYWRpb2w8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl

PkV1cm9wZWFuIGpvdXJuYWwgb2YgcmFkaW9sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PGFsdC1w

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEpvdXJuYWwgb2YgUmFkaW9sb2d5PC9mdWxs

LXRpdGxlPjxhYmJyLTE+RXVyLiBKLiBSYWRpb2wuPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48

cGFnZXM+NTUtNjA8L3BhZ2VzPjx2b2x1bWU+NzE8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48

ZWRpdGlvbj4yMDA4LzA1LzEzPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50

PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+

PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8gZGlhZ25vc2lzLyBldGlvbG9neTwva2V5d29yZD48a2V5

d29yZD5Bc3BlcmdpbGx1cy9pbW11bm9sb2d5LyBpc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9u

L21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkhl

bWF0b2xvZ2ljIE5lb3BsYXNtcy8gY29tcGxpY2F0aW9ucy8gZGlhZ25vc2lzPC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1h

bm5hbnMvIGJsb29kPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3

b3JkPlJlcHJvZHVjaWJpbGl0eSBvZiBSZXN1bHRzPC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgQXNz

ZXNzbWVudDwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tl

eXdvcmQ+PGtleXdvcmQ+U3RhdGlzdGljcyBhcyBUb3BpYzwva2V5d29yZD48a2V5d29yZD5Ub21v

Z3JhcGh5LCBYLVJheSBDb21wdXRlZC8gbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5Zb3VuZyBB

ZHVsdDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA5PC95ZWFyPjxwdWItZGF0

ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTg3Mi03NzI3IChF

bGVjdHJvbmljKSYjeEQ7MDcyMC0wNDhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4x

ODQ2ODgzMDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjEwLjEwMTYvai5lanJhZC4yMDA4LjAzLjAyNjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48

bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IaWRhbGdvPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48

UmVjTnVtPjEyMzk8L1JlY051bT48RGlzcGxheVRleHQ+WzEwM108L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MTIzOTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+MTIzOTwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+SGlkYWxnbywgQS48L2F1dGhvcj48

YXV0aG9yPlBhcm9keSwgUi48L2F1dGhvcj48YXV0aG9yPk1hcnRpbm8sIFIuPC9hdXRob3I+PGF1

dGhvcj5TYW5jaGV6LCBGLjwvYXV0aG9yPjxhdXRob3I+RnJhbnF1ZXQsIFQuPC9hdXRob3I+PGF1

dGhvcj5HaW1lbmV6LCBBLjwvYXV0aG9yPjxhdXRob3I+QmxhbmNhcywgQy48L2F1dGhvcj48L2F1

dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFJhZGlvbG9n

eSwgSG9zcGl0YWwgZGUgU2FudCBQYXUsIFVuaXZlcnNpZGFkIEF1dG9ub21hIGRlIEJhcmNlbG9u

YSwgQmFyY2Vsb25hLCBTcGFpbi4gYWxoaWRhbGdvcEB5YWhvby5lczwvYXV0aC1hZGRyZXNzPjx0

aXRsZXM+PHRpdGxlPkNvcnJlbGF0aW9uIGJldHdlZW4gaGlnaC1yZXNvbHV0aW9uIGNvbXB1dGVk

IHRvbW9ncmFwaHkgYW5kIGdhbGFjdG9tYW5uYW4gYW50aWdlbmVtaWEgaW4gYWR1bHQgaGVtYXRv

bG9naWMgcGF0aWVudHMgYXQgcmlzayBmb3IgaW52YXNpdmUgYXNwZXJnaWxsb3NpczwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5FdXIgSiBSYWRpb2w8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl

PkV1cm9wZWFuIGpvdXJuYWwgb2YgcmFkaW9sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PGFsdC1w

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEpvdXJuYWwgb2YgUmFkaW9sb2d5PC9mdWxs

LXRpdGxlPjxhYmJyLTE+RXVyLiBKLiBSYWRpb2wuPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48

cGFnZXM+NTUtNjA8L3BhZ2VzPjx2b2x1bWU+NzE8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48

ZWRpdGlvbj4yMDA4LzA1LzEzPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50

PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+

PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8gZGlhZ25vc2lzLyBldGlvbG9neTwva2V5d29yZD48a2V5

d29yZD5Bc3BlcmdpbGx1cy9pbW11bm9sb2d5LyBpc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9u

L21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkhl

bWF0b2xvZ2ljIE5lb3BsYXNtcy8gY29tcGxpY2F0aW9ucy8gZGlhZ25vc2lzPC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1h

bm5hbnMvIGJsb29kPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3

b3JkPlJlcHJvZHVjaWJpbGl0eSBvZiBSZXN1bHRzPC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgQXNz

ZXNzbWVudDwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tl

eXdvcmQ+PGtleXdvcmQ+U3RhdGlzdGljcyBhcyBUb3BpYzwva2V5d29yZD48a2V5d29yZD5Ub21v

Z3JhcGh5LCBYLVJheSBDb21wdXRlZC8gbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5Zb3VuZyBB

ZHVsdDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA5PC95ZWFyPjxwdWItZGF0

ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTg3Mi03NzI3IChF

bGVjdHJvbmljKSYjeEQ7MDcyMC0wNDhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4x

ODQ2ODgzMDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjEwLjEwMTYvai5lanJhZC4yMDA4LjAzLjAyNjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48

bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [103]. While earlier reports suggested that GM was not reliable in pediatric patients due to a high false-positive rate, several subsequent studies have shown its usefulness in children and similar operating characteristics to adult patients PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdGVpbmJhY2g8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFy

PjxSZWNOdW0+OTgzPC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMDQtMTExXTwvRGlzcGxheVRleHQ+

PHJlY29yZD48cmVjLW51bWJlcj45ODM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJwdzA1ZmZzZndyZXgiPjk4Mzwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U3RlaW5iYWNoLCBXIEo8L2F1

dGhvcj48YXV0aG9yPkFkZGlzb24sIFIgTTwvYXV0aG9yPjxhdXRob3I+TWNMYXVnaGxpbiwgTDwv

YXV0aG9yPjxhdXRob3I+R2VycmFsZCwgUTwvYXV0aG9yPjxhdXRob3I+TWFydGluLCBQIEw8L2F1

dGhvcj48YXV0aG9yPkRyaXNjb2xsLCBUPC9hdXRob3I+PGF1dGhvcj5CZW50c2VuLCBDPC9hdXRo

b3I+PGF1dGhvcj5QZXJmZWN0LCBKIFI8L2F1dGhvcj48YXV0aG9yPkFsZXhhbmRlciwgQiBEPC9h

dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPjxzdHlsZSBmYWNl

PSJub3JtYWwiIGZvbnQ9ImRlZmF1bHQiIHNpemU9IjEwMCUiPlByb3NwZWN0aXZlIDwvc3R5bGU+

PHN0eWxlIGZhY2U9Iml0YWxpYyIgZm9udD0iZGVmYXVsdCIgc2l6ZT0iMTAwJSI+QXNwZXJnaWxs

dXMgPC9zdHlsZT48c3R5bGUgZmFjZT0ibm9ybWFsIiBmb250PSJkZWZhdWx0IiBzaXplPSIxMDAl

Ij5nYWxhY3RvbWFubmFuIGFudGlnZW4gdGVzdGluZyBpbiBwZWRpYXRyaWMgaGVtYXRvcG9pZXRp

YyBzdGVtIGNlbGwgdHJhbnNwbGFudCByZWNpcGllbnRzPC9zdHlsZT48L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+UGVkaWF0cmljIEluZmVjdGlvdXMgRGlzZWFzZSBKb3VybmFsPC9zZWNvbmRhcnkt

dGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+UGVkaWF0cmljIEluZmVjdGlv

dXMgRGlzZWFzZSBKb3VybmFsPC9mdWxsLXRpdGxlPjxhYmJyLTE+UGVkaWF0ci4gSW5mZWN0LiBE

aXMuIEouPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxwYWdlcz41NTgtNTY0PC9wYWdlcz48dm9sdW1l

PjI2PC92b2x1bWU+PGRhdGVzPjx5ZWFyPjIwMDc8L3llYXI+PC9kYXRlcz48dXJscz48L3VybHM+

PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+SGF5ZGVuPC9BdXRob3I+PFllYXI+MjAwODwv

WWVhcj48UmVjTnVtPjk0MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+OTQxPC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0

ajVkdGRycHcwNWZmc2Z3cmV4Ij45NDE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPkhheWRlbiwgUjwvYXV0aG9yPjxhdXRob3I+UG91bmRzLCBTPC9hdXRob3I+PGF1dGhv

cj5LbmFwcCwgSzwvYXV0aG9yPjxhdXRob3I+UGV0cmFpdGllbmUsIFI8L2F1dGhvcj48YXV0aG9y

PlNjaGF1ZmVsZSwgUiBMPC9hdXRob3I+PGF1dGhvcj5TZWluLCBUPC9hdXRob3I+PGF1dGhvcj5X

YWxzaCwgVCBKPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxl

PkdhbGFjdG9tYW5uYW4gYW50aWdlbmVtaWEgaW4gcGVkaWF0cmljIG9uY29sb2d5IHBhdGllbnRz

IHdpdGggaW52YXNpdmUgYXNwZXJnaWxsb3NpczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5QZWRp

YXRyaWMgSW5mZWN0aW91cyBEaXNlYXNlIEpvdXJuYWw8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QZWRpYXRyaWMgSW5mZWN0aW91cyBEaXNlYXNlIEpv

dXJuYWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5QZWRpYXRyLiBJbmZlY3QuIERpcy4gSi48L2FiYnIt

MT48L3BlcmlvZGljYWw+PHBhZ2VzPjgxNS04MTk8L3BhZ2VzPjx2b2x1bWU+Mjc8L3ZvbHVtZT48

ZGF0ZXM+PHllYXI+MjAwODwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0Np

dGU+PENpdGU+PEF1dGhvcj5DYXN0YWdub2xhPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48UmVj

TnVtPjEwODk8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEwODk8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJw

dzA1ZmZzZndyZXgiPjEwODk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkNhc3RhZ25vbGEsIEU8L2F1dGhvcj48YXV0aG9yPkZ1cmZhcm8sIEU8L2F1dGhvcj48YXV0aG9y

PkNhdmlnbGlhLCBJPC9hdXRob3I+PGF1dGhvcj5MaWNjaWFyZGVsbG8sIE08L2F1dGhvcj48YXV0

aG9yPkZhcmFjaSwgTTwvYXV0aG9yPjxhdXRob3I+RmlvcmVkZGEsIEY8L2F1dGhvcj48YXV0aG9y

PlRvbcOgLCBQPC9hdXRob3I+PGF1dGhvcj5CYW5kZXR0aW5pLCBSPC9hdXRob3I+PGF1dGhvcj5N

YWNoZXR0aSwgTTwvYXV0aG9yPjxhdXRob3I+VmlzY29saSwgQzwvYXV0aG9yPjwvYXV0aG9ycz48

L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5QZXJmb3JtYW5jZSBvZiB0aGUgZ2FsYWN0b21h

bm5hbiBhbnRpZ2VuIGRldGVjdGlvbiB0ZXN0IGluIHRoZSBkaWFnbm9zaXMgb2YgaW52YXNpdmUg

YXNwZXJnaWxsb3NpcyBpbiBjaGlsZHJlbiB3aXRoIGNhbmNlciBvciB1bmRlcmdvaW5nIGhhZW1v

cG9pZXRpYyBzdGVtIGNlbGwgdHJhbnNwbGFudGF0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl

PkNsaW5pY2FsIE1pY3JvYmlvbG9neSBhbmQgSW5mZWN0aW9uPC9zZWNvbmRhcnktdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2xpbmljYWwgTWljcm9iaW9sb2d5IGFuZCBJ

bmZlY3Rpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5DbGluIE1pY3JvYmlvbCBJbmZlY3Q8L2FiYnIt

MT48L3BlcmlvZGljYWw+PHBhZ2VzPjExOTctMjAzPC9wYWdlcz48dm9sdW1lPjE2PC92b2x1bWU+

PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PC9kYXRlcz48dXJscz48L3VybHM+PC9yZWNvcmQ+PC9D

aXRlPjxDaXRlPjxBdXRob3I+RmlzaGVyPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVjTnVt

PjEyNDA8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEyNDA8L3JlYy1udW1iZXI+PGZvcmVp

Z24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJwdzA1

ZmZzZndyZXgiPjEyNDA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkZp

c2hlciwgQi4gVC48L2F1dGhvcj48YXV0aG9yPlphb3V0aXMsIFQuIEUuPC9hdXRob3I+PGF1dGhv

cj5QYXJrLCBKLiBSLjwvYXV0aG9yPjxhdXRob3I+QmxlYWtsZXksIE0uPC9hdXRob3I+PGF1dGhv

cj5FbmdsdW5kLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+S2FuZSwgQy48L2F1dGhvcj48YXV0aG9y

PkFyY2VjaSwgUi4gSi48L2F1dGhvcj48YXV0aG9yPkd1aW5hbiwgRS48L2F1dGhvcj48YXV0aG9y

PlNtaXRoLCBGLiBPLjwvYXV0aG9yPjxhdXRob3I+THVhbiwgWC48L2F1dGhvcj48YXV0aG9yPk1h

cnIsIEsuIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+

RGl2aXNpb24gb2YgSW5mZWN0aW91cyBEaXNlYXNlcyA7IENlbnRlciBmb3IgUGVkaWF0cmljIENs

aW5pY2FsIEVmZmVjdGl2ZW5lc3MsIFRoZSBDaGlsZHJlbiZhcG9zO3MgSG9zcGl0YWwgb2YgUGhp

bGFkZWxwaGlhLCBQZW5uc3lsdmFuaWEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R2Fs

YWN0b21hbm5hbiBBbnRpZ2VuIFRlc3RpbmcgZm9yIERpYWdub3NpcyBvZiBJbnZhc2l2ZSBBc3Bl

cmdpbGxvc2lzIGluIFBlZGlhdHJpYyBIZW1hdG9sb2d5IFBhdGllbnRzPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPkogUGVkaWF0cmljIEluZmVjdCBEaXMgU29jPC9zZWNvbmRhcnktdGl0bGU+PGFs

dC10aXRsZT5Kb3VybmFsIG9mIHRoZSBQZWRpYXRyaWMgSW5mZWN0aW91cyBEaXNlYXNlcyBTb2Np

ZXR5PC9hbHQtdGl0bGU+PC90aXRsZXM+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJu

YWwgb2YgdGhlIFBlZGlhdHJpYyBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNvY2lldHk8L2Z1bGwtdGl0

bGU+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTAzLTExMTwvcGFnZXM+PHZvbHVtZT4xPC92b2x1

bWU+PG51bWJlcj4yPC9udW1iZXI+PGVkaXRpb24+MjAxMy8wNS8yMTwvZWRpdGlvbj48ZGF0ZXM+

PHllYXI+MjAxMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48

L2RhdGVzPjxpc2JuPjIwNDgtNzE5MyAoUHJpbnQpJiN4RDsyMDQ4LTcxOTMgKExpbmtpbmcpPC9p

c2JuPjxhY2Nlc3Npb24tbnVtPjIzNjg3NTc1PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48

Y3VzdG9tMj4zNjU2NTUyPC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkz

L2pwaWRzL3BpczA0NDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nPC9sYW5n

dWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5EaW5hbmQ8L0F1dGhvcj48WWVhcj4y

MDE0PC9ZZWFyPjxSZWNOdW0+ODExPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj44MTE8L3Jl

Yy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53Mnpm

bWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM3MjY0OSI+ODExPC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5EaW5hbmQsIFYuPC9hdXRob3I+PGF1

dGhvcj5BbmphbiwgTS48L2F1dGhvcj48YXV0aG9yPk9iZXJvaSwgSi4gSy48L2F1dGhvcj48YXV0

aG9yPktoYW5uYSwgUy48L2F1dGhvcj48YXV0aG9yPllhZGF2LCBTLiBQLjwvYXV0aG9yPjxhdXRo

b3I+V2F0dGFsLCBDLjwvYXV0aG9yPjxhdXRob3I+U2FjaGRldmEsIEEuPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+UGVkaWF0cmljIEhlbWF0b2xvZ3kgT25j

b2xvZ3kgYW5kIEJvbmUgTWFycm93IFRyYW5zcG9ydCBVbml0LCBEZXBhcnRtZW50IG9mIFBlZGlh

dHJpY3MsIFNpciBHYW5nYSBSYW0gSG9zcGl0YWwsIFJhamVuZGVyIE5hZ2FyLCBOZXcgRGVsaGks

IEluZGlhLiYjeEQ7RGVwYXJ0bWVudCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3kgYW5kIEltbXVu

b2xvZ3ksIFNpciBHYW5nYSBSYW0gSG9zcGl0YWwsIFJhamVuZGVyIE5hZ2FyLCBOZXcgRGVsaGks

IEluZGlhLiYjeEQ7UGVkaWF0cmljIEhlbWF0b2xvZ3kgT25jb2xvZ3kgYW5kIEJvbmUgTWFycm93

IFRyYW5zcG9ydCBVbml0LCBEZXBhcnRtZW50IG9mIFBlZGlhdHJpY3MsIFNpciBHYW5nYSBSYW0g

SG9zcGl0YWwsIFJhamVuZGVyIE5hZ2FyLCBOZXcgRGVsaGksIEluZGlhLiBFbGVjdHJvbmljIGFk

ZHJlc3M6IGFudXBhbWFjZUB5YWhvby5jby5pbi48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRs

ZT5UaHJlc2hvbGQgb2YgZ2FsYWN0b21hbm5hbiBhbnRpZ2VuZW1pYSBwb3NpdGl2aXR5IGZvciBl

YXJseSBkaWFnbm9zaXMgb2YgaW52YXNpdmUgYXNwZXJnaWxsb3NpcyBpbiBuZXV0cm9wZW5pYyBj

aGlsZHJlbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIE1pY3JvYmlvbCBJbW11bm9sIEluZmVj

dDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJu

YWwgb2YgTWljcm9iaW9sb2d5LCBJbW11bm9sb2d5LCBhbmQgSW5mZWN0aW9uLiBXZWkgTWlhbiBZ

dSBHYW4gUmFuIFphIFpoaTwvZnVsbC10aXRsZT48YWJici0xPkouIE1pY3JvYmlvbC4gSW1tdW5v

bC4gSW5mZWN0LjwvYWJici0xPjxhYmJyLTI+SiBNaWNyb2Jpb2wgSW1tdW5vbCBJbmZlY3Q8L2Fi

YnItMj48YWJici0zPkpvdXJuYWwgb2YgTWljcm9iaW9sb2d5LCBJbW11bm9sb2d5LCAmYW1wOyBJ

bmZlY3Rpb24uIFdlaSBNaWFuIFl1IEdhbiBSYW4gWmEgWmhpPC9hYmJyLTM+PC9wZXJpb2RpY2Fs

PjxrZXl3b3Jkcz48a2V5d29yZD5Bc3BlcmdpbGxvc2lzPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxk

PC9rZXl3b3JkPjxrZXl3b3JkPkhlbWF0b2xvZ3kvb25jb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+

SW5mZWN0aW9ucyBpbiBpbW11bm9jb21wcm9taXNlZCBob3N0czwva2V5d29yZD48a2V5d29yZD5O

ZXV0cm9wZW5pYTwva2V5d29yZD48a2V5d29yZD5TdGVtIGNlbGwgdHJhbnNwbGFudGF0aW9uPC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5GZWIgMjc8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xOTk1LTkxMzMgKEVsZWN0

cm9uaWMpJiN4RDsxNjg0LTExODIgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0NTgy

NDY0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5j

YmkubmxtLm5paC5nb3YvcHVibWVkLzI0NTgyNDY0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxz

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouam1paS4yMDEzLjEyLjAwMzwvZWxl

Y3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+Q2hvaTwv

QXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051bT44MTI8L1JlY051bT48cmVjb3JkPjxyZWMt

bnVtYmVyPjgxMjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDU0Mzcy

Njc4Ij44MTI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRp

Y2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNob2ksIFMu

IEguPC9hdXRob3I+PGF1dGhvcj5LYW5nLCBFLiBTLjwvYXV0aG9yPjxhdXRob3I+RW8sIEguPC9h

dXRob3I+PGF1dGhvcj5Zb28sIFMuIFkuPC9hdXRob3I+PGF1dGhvcj5LaW0sIEouIEguPC9hdXRo

b3I+PGF1dGhvcj5Zb28sIEsuIEguPC9hdXRob3I+PGF1dGhvcj5TdW5nLCBLLiBXLjwvYXV0aG9y

PjxhdXRob3I+S29vLCBILiBILjwvYXV0aG9yPjxhdXRob3I+S2ltLCBZLiBKLjwvYXV0aG9yPjwv

YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgUGVkaWF0

cmljcywgU3VuZ2t5dW5rd2FuIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBTYW1zdW5n

IE1lZGljYWwgQ2VudGVyLCBTZW91bCwgS29yZWEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0

bGU+QXNwZXJnaWxsdXMgZ2FsYWN0b21hbm5hbiBhbnRpZ2VuIGFzc2F5IGFuZCBpbnZhc2l2ZSBh

c3BlcmdpbGxvc2lzIGluIHBlZGlhdHJpYyBjYW5jZXIgcGF0aWVudHMgYW5kIGhlbWF0b3BvaWV0

aWMgc3RlbSBjZWxsIHRyYW5zcGxhbnQgcmVjaXBpZW50czwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5QZWRpYXRyIEJsb29kIENhbmNlcjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPlBlZGlhdHJpYyBCbG9vZCAmYW1wOyBDYW5jZXI8L2Z1bGwtdGl0bGU+

PGFiYnItMT5QZWRpYXRyLiBCbG9vZCBDYW5jZXI8L2FiYnItMT48YWJici0yPlBlZGlhdHIgQmxv

b2QgQ2FuY2VyPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz4zMTYtMjI8L3BhZ2VzPjx2b2x1

bWU+NjA8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVz

Y2VudDwva2V5d29yZD48a2V5d29yZD5BbnRpZ2VucywgRnVuZ2FsLyphbmFseXNpczwva2V5d29y

ZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+Q2hp

bGQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5G

YWxzZSBQb3NpdGl2ZSBSZWFjdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPkhlbWF0b2xvZ2ljIE5lb3BsYXNtcy8qY29tcGxpY2F0aW9ucy9taWNyb2Jpb2xv

Z3k8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvcG9pZXRpYyBTdGVtIENlbGwgVHJhbnNwbGFudGF0

aW9uLyphZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxr

ZXl3b3JkPkltbXVub2VuenltZSBUZWNobmlxdWVzLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3Jk

PkluZmFudDwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMv

KmFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjxwdWItZGF0ZXM+PGRh

dGU+RmViPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU0NS01MDE3IChFbGVjdHJv

bmljKSYjeEQ7MTU0NS01MDA5IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMzA0Mjc2

MTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2Jp

Lm5sbS5uaWguZ292L3B1Ym1lZC8yMzA0Mjc2MTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48

ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAwMi9wYmMuMjQzNjM8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkpoYTwvQXV0aG9yPjxZZWFy

PjIwMTM8L1llYXI+PFJlY051bT4xMjQzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMjQz

PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5

emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjQzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJl

Zi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+

PGF1dGhvcnM+PGF1dGhvcj5KaGEsIEEuIEsuPC9hdXRob3I+PGF1dGhvcj5CYW5zYWwsIEQuPC9h

dXRob3I+PGF1dGhvcj5DaGFrcmFiYXJ0aSwgQS48L2F1dGhvcj48YXV0aG9yPlNoaXZhcHJha2Fz

aCwgTS4gUi48L2F1dGhvcj48YXV0aG9yPlRyZWhhbiwgQS48L2F1dGhvcj48YXV0aG9yPk1hcndh

aGEsIFIuIEsuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+

SGVtYXRvbG9neS1PbmNvbG9neSBVbml0LCBEZXBhcnRtZW50IG9mIFBlZGlhdHJpY3MsIEFkdmFu

Y2VkIFBlZGlhdHJpYyBDZW50ZXIsIFBvc3QgR3JhZHVhdGUgSW5zdGl0dXRlIG9mIE1lZGljYWwg

RWR1Y2F0aW9uIGFuZCBSZXNlYXJjaCwgQ2hhbmRpZ2FyaCwgSW5kaWEuPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+U2VydW0gZ2FsYWN0b21hbm5hbiBhc3NheSBmb3IgdGhlIGRpYWdub3Np

cyBvZiBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIGluIGNoaWxkcmVuIHdpdGggaGFlbWF0b2xvZ2lj

YWwgbWFsaWduYW5jaWVzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk15Y29zZXM8L3NlY29uZGFy

eS10aXRsZT48YWx0LXRpdGxlPk15Y29zZXM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5NeWNvc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+TXljb3NlczwvYWJici0x

PjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TXljb3NlczwvZnVsbC10

aXRsZT48YWJici0xPk15Y29zZXM8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz40NDIt

ODwvcGFnZXM+PHZvbHVtZT41Njwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxlZGl0aW9uPjIw

MTMvMDIvMDI8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+

PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29y

ZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+RnVuZ2VtaWEvIGRpYWdub3Npczwv

a2V5d29yZD48a2V5d29yZD5IZW1hdG9sb2dpYyBOZW9wbGFzbXMvIGNvbXBsaWNhdGlvbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluZmFudDwva2V5d29yZD48

a2V5d29yZD5JbnZhc2l2ZSBQdWxtb25hcnkgQXNwZXJnaWxsb3Npcy8gZGlhZ25vc2lzPC9rZXl3

b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8gYmxvb2Q8L2tleXdv

cmQ+PGtleXdvcmQ+UHJlZGljdGl2ZSBWYWx1ZSBvZiBUZXN0czwva2V5d29yZD48a2V5d29yZD5T

ZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+U2VydW0vY2hlbWlz

dHJ5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+PHB1Yi1kYXRl

cz48ZGF0ZT5KdWw8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDM5LTA1MDcgKEVs

ZWN0cm9uaWMpJiN4RDswOTMzLTc0MDcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIz

MzY5MDQ3PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTExMS9teWMuMTIwNDg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0

YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVu

ZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QmFkaWVlPC9BdXRob3I+

PFllYXI+MjAxMjwvWWVhcj48UmVjTnVtPjgxMzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+

ODEzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjV3czk5

cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9IjE0NTQzNzI3MjYiPjgx

Mzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3

PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QmFkaWVlLCBQLjwvYXV0

aG9yPjxhdXRob3I+QWxib3J6aSwgQS48L2F1dGhvcj48YXV0aG9yPkthcmltaSwgTS48L2F1dGhv

cj48YXV0aG9yPlBvdXJhYmJhcywgQi48L2F1dGhvcj48YXV0aG9yPkhhZGRhZGksIFAuPC9hdXRo

b3I+PGF1dGhvcj5NYXJkYW5laCwgSi48L2F1dGhvcj48YXV0aG9yPk1vaWVuaSwgTS48L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Qcm9mLiBBbGJvcnppIENs

aW5pY2FsIE1pY3JvYmlvbG9neSBSZXNlYXJjaCBDZW50ZXIsIFN0dWRlbnQgUmVzZWFyY2ggQ29t

bWl0dGVlLCBTaGlyYXogVW5pdmVyc2l0eSBvZiBNZWRpY2FsIFNjaWVuY2VzLCBTaGlyYXosIEly

YW4uIGJhZGllZXBAeWFob28uY29tPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RGlhZ25v

c3RpYyBwb3RlbnRpYWwgb2YgbmVzdGVkIFBDUiwgZ2FsYWN0b21hbm5hbiBFSUEsIGFuZCBiZXRh

LUQtZ2x1Y2FuIGZvciBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIGluIHBlZGlhdHJpYyBwYXRpZW50

czwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEluZmVjdCBEZXYgQ3RyaWVzPC9zZWNvbmRhcnkt

dGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBJbmZlY3QgRGV2IEN0cmll

czwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjM1Mi03PC9wYWdlcz48dm9sdW1lPjY8

L3ZvbHVtZT48bnVtYmVyPjQ8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwv

a2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy9jaGVtaXN0cnkvZ2VuZXRpY3MvKmlzb2xhdGlv

biAmYW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtl

eXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5DbGluaWNhbCBMYWJvcmF0

b3J5IFRlY2huaXF1ZXMvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9lbnp5bWUgVGVjaG5pcXVl

cy8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5JbmZhbnQ8L2tleXdvcmQ+PGtleXdvcmQ+SW52

YXNpdmUgUHVsbW9uYXJ5IEFzcGVyZ2lsbG9zaXMvKmRpYWdub3Npcy9taWNyb2Jpb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5zL2FuYWx5c2lzPC9r

ZXl3b3JkPjxrZXl3b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb24vKm1ldGhvZHM8L2tleXdv

cmQ+PGtleXdvcmQ+UmVhZ2VudCBLaXRzLCBEaWFnbm9zdGljPC9rZXl3b3JkPjxrZXl3b3JkPmJl

dGEtR2x1Y2Fucy9hbmFseXNpczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEy

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlz

Ym4+MTk3Mi0yNjgwIChFbGVjdHJvbmljKSYjeEQ7MTk3Mi0yNjgwIChMaW5raW5nKTwvaXNibj48

YWNjZXNzaW9uLW51bT4yMjUwNTQ0NjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxz

Pjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMjUwNTQ0NjwvdXJsPjwv

cmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdGVpbmJhY2g8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFy

PjxSZWNOdW0+OTgzPC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMDQtMTExXTwvRGlzcGxheVRleHQ+

PHJlY29yZD48cmVjLW51bWJlcj45ODM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJwdzA1ZmZzZndyZXgiPjk4Mzwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U3RlaW5iYWNoLCBXIEo8L2F1

dGhvcj48YXV0aG9yPkFkZGlzb24sIFIgTTwvYXV0aG9yPjxhdXRob3I+TWNMYXVnaGxpbiwgTDwv

YXV0aG9yPjxhdXRob3I+R2VycmFsZCwgUTwvYXV0aG9yPjxhdXRob3I+TWFydGluLCBQIEw8L2F1

dGhvcj48YXV0aG9yPkRyaXNjb2xsLCBUPC9hdXRob3I+PGF1dGhvcj5CZW50c2VuLCBDPC9hdXRo

b3I+PGF1dGhvcj5QZXJmZWN0LCBKIFI8L2F1dGhvcj48YXV0aG9yPkFsZXhhbmRlciwgQiBEPC9h

dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPjxzdHlsZSBmYWNl

PSJub3JtYWwiIGZvbnQ9ImRlZmF1bHQiIHNpemU9IjEwMCUiPlByb3NwZWN0aXZlIDwvc3R5bGU+

PHN0eWxlIGZhY2U9Iml0YWxpYyIgZm9udD0iZGVmYXVsdCIgc2l6ZT0iMTAwJSI+QXNwZXJnaWxs

dXMgPC9zdHlsZT48c3R5bGUgZmFjZT0ibm9ybWFsIiBmb250PSJkZWZhdWx0IiBzaXplPSIxMDAl

Ij5nYWxhY3RvbWFubmFuIGFudGlnZW4gdGVzdGluZyBpbiBwZWRpYXRyaWMgaGVtYXRvcG9pZXRp

YyBzdGVtIGNlbGwgdHJhbnNwbGFudCByZWNpcGllbnRzPC9zdHlsZT48L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+UGVkaWF0cmljIEluZmVjdGlvdXMgRGlzZWFzZSBKb3VybmFsPC9zZWNvbmRhcnkt

dGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+UGVkaWF0cmljIEluZmVjdGlv

dXMgRGlzZWFzZSBKb3VybmFsPC9mdWxsLXRpdGxlPjxhYmJyLTE+UGVkaWF0ci4gSW5mZWN0LiBE

aXMuIEouPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxwYWdlcz41NTgtNTY0PC9wYWdlcz48dm9sdW1l

PjI2PC92b2x1bWU+PGRhdGVzPjx5ZWFyPjIwMDc8L3llYXI+PC9kYXRlcz48dXJscz48L3VybHM+

PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+SGF5ZGVuPC9BdXRob3I+PFllYXI+MjAwODwv

WWVhcj48UmVjTnVtPjk0MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+OTQxPC9yZWMtbnVt

YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0

ajVkdGRycHcwNWZmc2Z3cmV4Ij45NDE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPkhheWRlbiwgUjwvYXV0aG9yPjxhdXRob3I+UG91bmRzLCBTPC9hdXRob3I+PGF1dGhv

cj5LbmFwcCwgSzwvYXV0aG9yPjxhdXRob3I+UGV0cmFpdGllbmUsIFI8L2F1dGhvcj48YXV0aG9y

PlNjaGF1ZmVsZSwgUiBMPC9hdXRob3I+PGF1dGhvcj5TZWluLCBUPC9hdXRob3I+PGF1dGhvcj5X

YWxzaCwgVCBKPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxl

PkdhbGFjdG9tYW5uYW4gYW50aWdlbmVtaWEgaW4gcGVkaWF0cmljIG9uY29sb2d5IHBhdGllbnRz

IHdpdGggaW52YXNpdmUgYXNwZXJnaWxsb3NpczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5QZWRp

YXRyaWMgSW5mZWN0aW91cyBEaXNlYXNlIEpvdXJuYWw8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QZWRpYXRyaWMgSW5mZWN0aW91cyBEaXNlYXNlIEpv

dXJuYWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5QZWRpYXRyLiBJbmZlY3QuIERpcy4gSi48L2FiYnIt

MT48L3BlcmlvZGljYWw+PHBhZ2VzPjgxNS04MTk8L3BhZ2VzPjx2b2x1bWU+Mjc8L3ZvbHVtZT48

ZGF0ZXM+PHllYXI+MjAwODwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0Np

dGU+PENpdGU+PEF1dGhvcj5DYXN0YWdub2xhPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48UmVj

TnVtPjEwODk8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEwODk8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJw

dzA1ZmZzZndyZXgiPjEwODk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkNhc3RhZ25vbGEsIEU8L2F1dGhvcj48YXV0aG9yPkZ1cmZhcm8sIEU8L2F1dGhvcj48YXV0aG9y

PkNhdmlnbGlhLCBJPC9hdXRob3I+PGF1dGhvcj5MaWNjaWFyZGVsbG8sIE08L2F1dGhvcj48YXV0

aG9yPkZhcmFjaSwgTTwvYXV0aG9yPjxhdXRob3I+RmlvcmVkZGEsIEY8L2F1dGhvcj48YXV0aG9y

PlRvbcOgLCBQPC9hdXRob3I+PGF1dGhvcj5CYW5kZXR0aW5pLCBSPC9hdXRob3I+PGF1dGhvcj5N

YWNoZXR0aSwgTTwvYXV0aG9yPjxhdXRob3I+VmlzY29saSwgQzwvYXV0aG9yPjwvYXV0aG9ycz48

L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5QZXJmb3JtYW5jZSBvZiB0aGUgZ2FsYWN0b21h

bm5hbiBhbnRpZ2VuIGRldGVjdGlvbiB0ZXN0IGluIHRoZSBkaWFnbm9zaXMgb2YgaW52YXNpdmUg

YXNwZXJnaWxsb3NpcyBpbiBjaGlsZHJlbiB3aXRoIGNhbmNlciBvciB1bmRlcmdvaW5nIGhhZW1v

cG9pZXRpYyBzdGVtIGNlbGwgdHJhbnNwbGFudGF0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl

PkNsaW5pY2FsIE1pY3JvYmlvbG9neSBhbmQgSW5mZWN0aW9uPC9zZWNvbmRhcnktdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2xpbmljYWwgTWljcm9iaW9sb2d5IGFuZCBJ

bmZlY3Rpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5DbGluIE1pY3JvYmlvbCBJbmZlY3Q8L2FiYnIt

MT48L3BlcmlvZGljYWw+PHBhZ2VzPjExOTctMjAzPC9wYWdlcz48dm9sdW1lPjE2PC92b2x1bWU+

PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PC9kYXRlcz48dXJscz48L3VybHM+PC9yZWNvcmQ+PC9D

aXRlPjxDaXRlPjxBdXRob3I+RmlzaGVyPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVjTnVt

PjEyNDA8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEyNDA8L3JlYy1udW1iZXI+PGZvcmVp

Z24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJwdzA1

ZmZzZndyZXgiPjEyNDA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkZp

c2hlciwgQi4gVC48L2F1dGhvcj48YXV0aG9yPlphb3V0aXMsIFQuIEUuPC9hdXRob3I+PGF1dGhv

cj5QYXJrLCBKLiBSLjwvYXV0aG9yPjxhdXRob3I+QmxlYWtsZXksIE0uPC9hdXRob3I+PGF1dGhv

cj5FbmdsdW5kLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+S2FuZSwgQy48L2F1dGhvcj48YXV0aG9y

PkFyY2VjaSwgUi4gSi48L2F1dGhvcj48YXV0aG9yPkd1aW5hbiwgRS48L2F1dGhvcj48YXV0aG9y

PlNtaXRoLCBGLiBPLjwvYXV0aG9yPjxhdXRob3I+THVhbiwgWC48L2F1dGhvcj48YXV0aG9yPk1h

cnIsIEsuIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+

RGl2aXNpb24gb2YgSW5mZWN0aW91cyBEaXNlYXNlcyA7IENlbnRlciBmb3IgUGVkaWF0cmljIENs

aW5pY2FsIEVmZmVjdGl2ZW5lc3MsIFRoZSBDaGlsZHJlbiZhcG9zO3MgSG9zcGl0YWwgb2YgUGhp

bGFkZWxwaGlhLCBQZW5uc3lsdmFuaWEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R2Fs

YWN0b21hbm5hbiBBbnRpZ2VuIFRlc3RpbmcgZm9yIERpYWdub3NpcyBvZiBJbnZhc2l2ZSBBc3Bl

cmdpbGxvc2lzIGluIFBlZGlhdHJpYyBIZW1hdG9sb2d5IFBhdGllbnRzPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPkogUGVkaWF0cmljIEluZmVjdCBEaXMgU29jPC9zZWNvbmRhcnktdGl0bGU+PGFs

dC10aXRsZT5Kb3VybmFsIG9mIHRoZSBQZWRpYXRyaWMgSW5mZWN0aW91cyBEaXNlYXNlcyBTb2Np

ZXR5PC9hbHQtdGl0bGU+PC90aXRsZXM+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJu

YWwgb2YgdGhlIFBlZGlhdHJpYyBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNvY2lldHk8L2Z1bGwtdGl0

bGU+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTAzLTExMTwvcGFnZXM+PHZvbHVtZT4xPC92b2x1

bWU+PG51bWJlcj4yPC9udW1iZXI+PGVkaXRpb24+MjAxMy8wNS8yMTwvZWRpdGlvbj48ZGF0ZXM+

PHllYXI+MjAxMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48

L2RhdGVzPjxpc2JuPjIwNDgtNzE5MyAoUHJpbnQpJiN4RDsyMDQ4LTcxOTMgKExpbmtpbmcpPC9p

c2JuPjxhY2Nlc3Npb24tbnVtPjIzNjg3NTc1PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48

Y3VzdG9tMj4zNjU2NTUyPC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDkz

L2pwaWRzL3BpczA0NDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nPC9sYW5n

dWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5EaW5hbmQ8L0F1dGhvcj48WWVhcj4y

MDE0PC9ZZWFyPjxSZWNOdW0+ODExPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj44MTE8L3Jl

Yy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyNXdzOTlyZm53Mnpm

bWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1NDM3MjY0OSI+ODExPC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5EaW5hbmQsIFYuPC9hdXRob3I+PGF1

dGhvcj5BbmphbiwgTS48L2F1dGhvcj48YXV0aG9yPk9iZXJvaSwgSi4gSy48L2F1dGhvcj48YXV0

aG9yPktoYW5uYSwgUy48L2F1dGhvcj48YXV0aG9yPllhZGF2LCBTLiBQLjwvYXV0aG9yPjxhdXRo

b3I+V2F0dGFsLCBDLjwvYXV0aG9yPjxhdXRob3I+U2FjaGRldmEsIEEuPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+UGVkaWF0cmljIEhlbWF0b2xvZ3kgT25j

b2xvZ3kgYW5kIEJvbmUgTWFycm93IFRyYW5zcG9ydCBVbml0LCBEZXBhcnRtZW50IG9mIFBlZGlh

dHJpY3MsIFNpciBHYW5nYSBSYW0gSG9zcGl0YWwsIFJhamVuZGVyIE5hZ2FyLCBOZXcgRGVsaGks

IEluZGlhLiYjeEQ7RGVwYXJ0bWVudCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3kgYW5kIEltbXVu

b2xvZ3ksIFNpciBHYW5nYSBSYW0gSG9zcGl0YWwsIFJhamVuZGVyIE5hZ2FyLCBOZXcgRGVsaGks

IEluZGlhLiYjeEQ7UGVkaWF0cmljIEhlbWF0b2xvZ3kgT25jb2xvZ3kgYW5kIEJvbmUgTWFycm93

IFRyYW5zcG9ydCBVbml0LCBEZXBhcnRtZW50IG9mIFBlZGlhdHJpY3MsIFNpciBHYW5nYSBSYW0g

SG9zcGl0YWwsIFJhamVuZGVyIE5hZ2FyLCBOZXcgRGVsaGksIEluZGlhLiBFbGVjdHJvbmljIGFk

ZHJlc3M6IGFudXBhbWFjZUB5YWhvby5jby5pbi48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRs

ZT5UaHJlc2hvbGQgb2YgZ2FsYWN0b21hbm5hbiBhbnRpZ2VuZW1pYSBwb3NpdGl2aXR5IGZvciBl

YXJseSBkaWFnbm9zaXMgb2YgaW52YXNpdmUgYXNwZXJnaWxsb3NpcyBpbiBuZXV0cm9wZW5pYyBj

aGlsZHJlbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIE1pY3JvYmlvbCBJbW11bm9sIEluZmVj

dDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJu

YWwgb2YgTWljcm9iaW9sb2d5LCBJbW11bm9sb2d5LCBhbmQgSW5mZWN0aW9uLiBXZWkgTWlhbiBZ

dSBHYW4gUmFuIFphIFpoaTwvZnVsbC10aXRsZT48YWJici0xPkouIE1pY3JvYmlvbC4gSW1tdW5v

bC4gSW5mZWN0LjwvYWJici0xPjxhYmJyLTI+SiBNaWNyb2Jpb2wgSW1tdW5vbCBJbmZlY3Q8L2Fi

YnItMj48YWJici0zPkpvdXJuYWwgb2YgTWljcm9iaW9sb2d5LCBJbW11bm9sb2d5LCAmYW1wOyBJ

bmZlY3Rpb24uIFdlaSBNaWFuIFl1IEdhbiBSYW4gWmEgWmhpPC9hYmJyLTM+PC9wZXJpb2RpY2Fs

PjxrZXl3b3Jkcz48a2V5d29yZD5Bc3BlcmdpbGxvc2lzPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxk

PC9rZXl3b3JkPjxrZXl3b3JkPkhlbWF0b2xvZ3kvb25jb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+

SW5mZWN0aW9ucyBpbiBpbW11bm9jb21wcm9taXNlZCBob3N0czwva2V5d29yZD48a2V5d29yZD5O

ZXV0cm9wZW5pYTwva2V5d29yZD48a2V5d29yZD5TdGVtIGNlbGwgdHJhbnNwbGFudGF0aW9uPC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0

ZT5GZWIgMjc8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xOTk1LTkxMzMgKEVsZWN0

cm9uaWMpJiN4RDsxNjg0LTExODIgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0NTgy

NDY0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5j

YmkubmxtLm5paC5nb3YvcHVibWVkLzI0NTgyNDY0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxz

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouam1paS4yMDEzLjEyLjAwMzwvZWxl

Y3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+Q2hvaTwv

QXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051bT44MTI8L1JlY051bT48cmVjb3JkPjxyZWMt

bnVtYmVyPjgxMjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDU0Mzcy

Njc4Ij44MTI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRp

Y2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNob2ksIFMu

IEguPC9hdXRob3I+PGF1dGhvcj5LYW5nLCBFLiBTLjwvYXV0aG9yPjxhdXRob3I+RW8sIEguPC9h

dXRob3I+PGF1dGhvcj5Zb28sIFMuIFkuPC9hdXRob3I+PGF1dGhvcj5LaW0sIEouIEguPC9hdXRo

b3I+PGF1dGhvcj5Zb28sIEsuIEguPC9hdXRob3I+PGF1dGhvcj5TdW5nLCBLLiBXLjwvYXV0aG9y

PjxhdXRob3I+S29vLCBILiBILjwvYXV0aG9yPjxhdXRob3I+S2ltLCBZLiBKLjwvYXV0aG9yPjwv

YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgUGVkaWF0

cmljcywgU3VuZ2t5dW5rd2FuIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBTYW1zdW5n

IE1lZGljYWwgQ2VudGVyLCBTZW91bCwgS29yZWEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0

bGU+QXNwZXJnaWxsdXMgZ2FsYWN0b21hbm5hbiBhbnRpZ2VuIGFzc2F5IGFuZCBpbnZhc2l2ZSBh

c3BlcmdpbGxvc2lzIGluIHBlZGlhdHJpYyBjYW5jZXIgcGF0aWVudHMgYW5kIGhlbWF0b3BvaWV0

aWMgc3RlbSBjZWxsIHRyYW5zcGxhbnQgcmVjaXBpZW50czwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5QZWRpYXRyIEJsb29kIENhbmNlcjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPlBlZGlhdHJpYyBCbG9vZCAmYW1wOyBDYW5jZXI8L2Z1bGwtdGl0bGU+

PGFiYnItMT5QZWRpYXRyLiBCbG9vZCBDYW5jZXI8L2FiYnItMT48YWJici0yPlBlZGlhdHIgQmxv

b2QgQ2FuY2VyPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz4zMTYtMjI8L3BhZ2VzPjx2b2x1

bWU+NjA8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVz

Y2VudDwva2V5d29yZD48a2V5d29yZD5BbnRpZ2VucywgRnVuZ2FsLyphbmFseXNpczwva2V5d29y

ZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+Q2hp

bGQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5G

YWxzZSBQb3NpdGl2ZSBSZWFjdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPkhlbWF0b2xvZ2ljIE5lb3BsYXNtcy8qY29tcGxpY2F0aW9ucy9taWNyb2Jpb2xv

Z3k8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvcG9pZXRpYyBTdGVtIENlbGwgVHJhbnNwbGFudGF0

aW9uLyphZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxr

ZXl3b3JkPkltbXVub2VuenltZSBUZWNobmlxdWVzLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3Jk

PkluZmFudDwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMv

KmFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjxwdWItZGF0ZXM+PGRh

dGU+RmViPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU0NS01MDE3IChFbGVjdHJv

bmljKSYjeEQ7MTU0NS01MDA5IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMzA0Mjc2

MTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2Jp

Lm5sbS5uaWguZ292L3B1Ym1lZC8yMzA0Mjc2MTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48

ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAwMi9wYmMuMjQzNjM8L2VsZWN0cm9uaWMtcmVz

b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkpoYTwvQXV0aG9yPjxZZWFy

PjIwMTM8L1llYXI+PFJlY051bT4xMjQzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMjQz

PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5

emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjQzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJl

Zi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+

PGF1dGhvcnM+PGF1dGhvcj5KaGEsIEEuIEsuPC9hdXRob3I+PGF1dGhvcj5CYW5zYWwsIEQuPC9h

dXRob3I+PGF1dGhvcj5DaGFrcmFiYXJ0aSwgQS48L2F1dGhvcj48YXV0aG9yPlNoaXZhcHJha2Fz

aCwgTS4gUi48L2F1dGhvcj48YXV0aG9yPlRyZWhhbiwgQS48L2F1dGhvcj48YXV0aG9yPk1hcndh

aGEsIFIuIEsuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+

SGVtYXRvbG9neS1PbmNvbG9neSBVbml0LCBEZXBhcnRtZW50IG9mIFBlZGlhdHJpY3MsIEFkdmFu

Y2VkIFBlZGlhdHJpYyBDZW50ZXIsIFBvc3QgR3JhZHVhdGUgSW5zdGl0dXRlIG9mIE1lZGljYWwg

RWR1Y2F0aW9uIGFuZCBSZXNlYXJjaCwgQ2hhbmRpZ2FyaCwgSW5kaWEuPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+U2VydW0gZ2FsYWN0b21hbm5hbiBhc3NheSBmb3IgdGhlIGRpYWdub3Np

cyBvZiBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIGluIGNoaWxkcmVuIHdpdGggaGFlbWF0b2xvZ2lj

YWwgbWFsaWduYW5jaWVzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk15Y29zZXM8L3NlY29uZGFy

eS10aXRsZT48YWx0LXRpdGxlPk15Y29zZXM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5NeWNvc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+TXljb3NlczwvYWJici0x

PjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TXljb3NlczwvZnVsbC10

aXRsZT48YWJici0xPk15Y29zZXM8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz40NDIt

ODwvcGFnZXM+PHZvbHVtZT41Njwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxlZGl0aW9uPjIw

MTMvMDIvMDI8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+

PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29y

ZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+RnVuZ2VtaWEvIGRpYWdub3Npczwv

a2V5d29yZD48a2V5d29yZD5IZW1hdG9sb2dpYyBOZW9wbGFzbXMvIGNvbXBsaWNhdGlvbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluZmFudDwva2V5d29yZD48

a2V5d29yZD5JbnZhc2l2ZSBQdWxtb25hcnkgQXNwZXJnaWxsb3Npcy8gZGlhZ25vc2lzPC9rZXl3

b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8gYmxvb2Q8L2tleXdv

cmQ+PGtleXdvcmQ+UHJlZGljdGl2ZSBWYWx1ZSBvZiBUZXN0czwva2V5d29yZD48a2V5d29yZD5T

ZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+U2VydW0vY2hlbWlz

dHJ5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+PHB1Yi1kYXRl

cz48ZGF0ZT5KdWw8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDM5LTA1MDcgKEVs

ZWN0cm9uaWMpJiN4RDswOTMzLTc0MDcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIz

MzY5MDQ3PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTExMS9teWMuMTIwNDg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0

YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVu

ZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QmFkaWVlPC9BdXRob3I+

PFllYXI+MjAxMjwvWWVhcj48UmVjTnVtPjgxMzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+

ODEzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjV3czk5

cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9IjE0NTQzNzI3MjYiPjgx

Mzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3

PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QmFkaWVlLCBQLjwvYXV0

aG9yPjxhdXRob3I+QWxib3J6aSwgQS48L2F1dGhvcj48YXV0aG9yPkthcmltaSwgTS48L2F1dGhv

cj48YXV0aG9yPlBvdXJhYmJhcywgQi48L2F1dGhvcj48YXV0aG9yPkhhZGRhZGksIFAuPC9hdXRo

b3I+PGF1dGhvcj5NYXJkYW5laCwgSi48L2F1dGhvcj48YXV0aG9yPk1vaWVuaSwgTS48L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Qcm9mLiBBbGJvcnppIENs

aW5pY2FsIE1pY3JvYmlvbG9neSBSZXNlYXJjaCBDZW50ZXIsIFN0dWRlbnQgUmVzZWFyY2ggQ29t

bWl0dGVlLCBTaGlyYXogVW5pdmVyc2l0eSBvZiBNZWRpY2FsIFNjaWVuY2VzLCBTaGlyYXosIEly

YW4uIGJhZGllZXBAeWFob28uY29tPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RGlhZ25v

c3RpYyBwb3RlbnRpYWwgb2YgbmVzdGVkIFBDUiwgZ2FsYWN0b21hbm5hbiBFSUEsIGFuZCBiZXRh

LUQtZ2x1Y2FuIGZvciBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIGluIHBlZGlhdHJpYyBwYXRpZW50

czwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEluZmVjdCBEZXYgQ3RyaWVzPC9zZWNvbmRhcnkt

dGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBJbmZlY3QgRGV2IEN0cmll

czwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjM1Mi03PC9wYWdlcz48dm9sdW1lPjY8

L3ZvbHVtZT48bnVtYmVyPjQ8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwv

a2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy9jaGVtaXN0cnkvZ2VuZXRpY3MvKmlzb2xhdGlv

biAmYW1wOyBwdXJpZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtl

eXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5DbGluaWNhbCBMYWJvcmF0

b3J5IFRlY2huaXF1ZXMvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9lbnp5bWUgVGVjaG5pcXVl

cy8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5JbmZhbnQ8L2tleXdvcmQ+PGtleXdvcmQ+SW52

YXNpdmUgUHVsbW9uYXJ5IEFzcGVyZ2lsbG9zaXMvKmRpYWdub3Npcy9taWNyb2Jpb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5zL2FuYWx5c2lzPC9r

ZXl3b3JkPjxrZXl3b3JkPlBvbHltZXJhc2UgQ2hhaW4gUmVhY3Rpb24vKm1ldGhvZHM8L2tleXdv

cmQ+PGtleXdvcmQ+UmVhZ2VudCBLaXRzLCBEaWFnbm9zdGljPC9rZXl3b3JkPjxrZXl3b3JkPmJl

dGEtR2x1Y2Fucy9hbmFseXNpczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEy

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlz

Ym4+MTk3Mi0yNjgwIChFbGVjdHJvbmljKSYjeEQ7MTk3Mi0yNjgwIChMaW5raW5nKTwvaXNibj48

YWNjZXNzaW9uLW51bT4yMjUwNTQ0NjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxz

Pjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMjUwNTQ0NjwvdXJsPjwv

cmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [104-111]. Serum GM was not sensitive (38%) in patients with aspergilloma, but improved in those with hemoptysis PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJrPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj

TnVtPjEyNDQ8L1JlY051bT48RGlzcGxheVRleHQ+WzExMl08L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+MTI0NDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+MTI0NDwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UGFyaywgUy4gWS48L2F1dGhvcj48YXV0

aG9yPkxlZSwgUy4gTy48L2F1dGhvcj48YXV0aG9yPkNob2ksIFMuIEguPC9hdXRob3I+PGF1dGhv

cj5KZW9uZywgSi4gWS48L2F1dGhvcj48YXV0aG9yPlN1bmcsIEguPC9hdXRob3I+PGF1dGhvcj5L

aW0sIE0uIE4uPC9hdXRob3I+PGF1dGhvcj5DaG9pLCBDLiBNLjwvYXV0aG9yPjxhdXRob3I+SG9u

ZywgUy4gQi48L2F1dGhvcj48YXV0aG9yPk9oLCBZLiBNLjwvYXV0aG9yPjxhdXRob3I+U2hpbSwg

VC4gUy48L2F1dGhvcj48YXV0aG9yPkxpbSwgQy4gTS48L2F1dGhvcj48YXV0aG9yPktvaCwgWS48

L2F1dGhvcj48YXV0aG9yPktpbSwgRC4gUy48L2F1dGhvcj48YXV0aG9yPktpbSwgWS4gUy48L2F1

dGhvcj48YXV0aG9yPldvbywgSi4gSC48L2F1dGhvcj48YXV0aG9yPktpbSwgUy4gSC48L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIElu

ZmVjdGlvdXMgRGlzZWFzZXMsIEFzYW4gTWVkaWNhbCBDZW50ZXIsIFVuaXZlcnNpdHkgb2YgVWxz

YW4gQ29sbGVnZSBvZiBNZWRpY2luZSwgU2VvdWwsIFJlcHVibGljIG9mIEtvcmVhLjwvYXV0aC1h

ZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlNlcnVtIGFuZCBicm9uY2hvYWx2ZW9sYXIgbGF2YWdlIGZs

dWlkIGdhbGFjdG9tYW5uYW4gYXNzYXlzIGluIHBhdGllbnRzIHdpdGggcHVsbW9uYXJ5IGFzcGVy

Z2lsbG9tYTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vh

c2VzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5DbGluaWNhbCBpbmZlY3Rpb3VzIGRpc2Vh

c2VzIDogYW4gb2ZmaWNpYWwgcHVibGljYXRpb24gb2YgdGhlIEluZmVjdGlvdXMgRGlzZWFzZXMg

U29jaWV0eSBvZiBBbWVyaWNhPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+Q2xpbmljYWwgSW5mZWN0aW91cyBEaXNlYXNlczwvZnVsbC10aXRsZT48YWJici0xPkNs

aW4gSW5mZWN0IERpczwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+ZTE0OS01MjwvcGFnZXM+

PHZvbHVtZT41Mjwvdm9sdW1lPjxudW1iZXI+NzwvbnVtYmVyPjxlZGl0aW9uPjIwMTEvMDMvMjQ8

L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8

L2tleXdvcmQ+PGtleXdvcmQ+QnJvbmNob2FsdmVvbGFyIExhdmFnZSBGbHVpZC8gY2hlbWlzdHJ5

PC9rZXl3b3JkPjxrZXl3b3JkPkNsaW5pY2FsIExhYm9yYXRvcnkgVGVjaG5pcXVlcy8gbWV0aG9k

czwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3

b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8gYW5hbHlzaXM8L2tl

eXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UHVsbW9uYXJ5IEFz

cGVyZ2lsbG9zaXMvIGRpYWdub3Npczwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQg

U3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+U2VydW0vIGNoZW1pc3RyeTwva2V5d29yZD48

L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByIDE8

L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4

RDsxMDU4LTQ4MzggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxNDI3Mzg3PC9hY2Nl

c3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9j

aWQvY2lyMDI3PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3Zp

ZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdl

PjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJrPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj

TnVtPjEyNDQ8L1JlY051bT48RGlzcGxheVRleHQ+WzExMl08L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+MTI0NDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+MTI0NDwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UGFyaywgUy4gWS48L2F1dGhvcj48YXV0

aG9yPkxlZSwgUy4gTy48L2F1dGhvcj48YXV0aG9yPkNob2ksIFMuIEguPC9hdXRob3I+PGF1dGhv

cj5KZW9uZywgSi4gWS48L2F1dGhvcj48YXV0aG9yPlN1bmcsIEguPC9hdXRob3I+PGF1dGhvcj5L

aW0sIE0uIE4uPC9hdXRob3I+PGF1dGhvcj5DaG9pLCBDLiBNLjwvYXV0aG9yPjxhdXRob3I+SG9u

ZywgUy4gQi48L2F1dGhvcj48YXV0aG9yPk9oLCBZLiBNLjwvYXV0aG9yPjxhdXRob3I+U2hpbSwg

VC4gUy48L2F1dGhvcj48YXV0aG9yPkxpbSwgQy4gTS48L2F1dGhvcj48YXV0aG9yPktvaCwgWS48

L2F1dGhvcj48YXV0aG9yPktpbSwgRC4gUy48L2F1dGhvcj48YXV0aG9yPktpbSwgWS4gUy48L2F1

dGhvcj48YXV0aG9yPldvbywgSi4gSC48L2F1dGhvcj48YXV0aG9yPktpbSwgUy4gSC48L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIElu

ZmVjdGlvdXMgRGlzZWFzZXMsIEFzYW4gTWVkaWNhbCBDZW50ZXIsIFVuaXZlcnNpdHkgb2YgVWxz

YW4gQ29sbGVnZSBvZiBNZWRpY2luZSwgU2VvdWwsIFJlcHVibGljIG9mIEtvcmVhLjwvYXV0aC1h

ZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlNlcnVtIGFuZCBicm9uY2hvYWx2ZW9sYXIgbGF2YWdlIGZs

dWlkIGdhbGFjdG9tYW5uYW4gYXNzYXlzIGluIHBhdGllbnRzIHdpdGggcHVsbW9uYXJ5IGFzcGVy

Z2lsbG9tYTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vh

c2VzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5DbGluaWNhbCBpbmZlY3Rpb3VzIGRpc2Vh

c2VzIDogYW4gb2ZmaWNpYWwgcHVibGljYXRpb24gb2YgdGhlIEluZmVjdGlvdXMgRGlzZWFzZXMg

U29jaWV0eSBvZiBBbWVyaWNhPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+Q2xpbmljYWwgSW5mZWN0aW91cyBEaXNlYXNlczwvZnVsbC10aXRsZT48YWJici0xPkNs

aW4gSW5mZWN0IERpczwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+ZTE0OS01MjwvcGFnZXM+

PHZvbHVtZT41Mjwvdm9sdW1lPjxudW1iZXI+NzwvbnVtYmVyPjxlZGl0aW9uPjIwMTEvMDMvMjQ8

L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8

L2tleXdvcmQ+PGtleXdvcmQ+QnJvbmNob2FsdmVvbGFyIExhdmFnZSBGbHVpZC8gY2hlbWlzdHJ5

PC9rZXl3b3JkPjxrZXl3b3JkPkNsaW5pY2FsIExhYm9yYXRvcnkgVGVjaG5pcXVlcy8gbWV0aG9k

czwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3

b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8gYW5hbHlzaXM8L2tl

eXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UHVsbW9uYXJ5IEFz

cGVyZ2lsbG9zaXMvIGRpYWdub3Npczwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQg

U3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+U2VydW0vIGNoZW1pc3RyeTwva2V5d29yZD48

L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByIDE8

L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4

RDsxMDU4LTQ4MzggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxNDI3Mzg3PC9hY2Nl

c3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9j

aWQvY2lyMDI3PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3Zp

ZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdl

PjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [112], and also not sensitive (23%) in patients with chronic pulmonary aspergillosis PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGluPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj

TnVtPjEyNDU8L1JlY051bT48RGlzcGxheVRleHQ+WzExM108L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+MTI0NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+MTI0NTwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U2hpbiwgQi48L2F1dGhvcj48YXV0aG9y

PktvaCwgVy4gSi48L2F1dGhvcj48YXV0aG9yPkplb25nLCBCLiBILjwvYXV0aG9yPjxhdXRob3I+

WW9vLCBILjwvYXV0aG9yPjxhdXRob3I+UGFyaywgSC4gWS48L2F1dGhvcj48YXV0aG9yPlN1aCwg

Ry4gWS48L2F1dGhvcj48YXV0aG9yPkt3b24sIE8uIEouPC9hdXRob3I+PGF1dGhvcj5KZW9uLCBL

LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlzaW9u

IG9mIFB1bG1vbmFyeSBhbmQgQ3JpdGljYWwgQ2FyZSBNZWRpY2luZSwgRGVwYXJ0bWVudCBvZiBN

ZWRpY2luZSwgU2Ftc3VuZyBNZWRpY2FsIENlbnRlciwgU3VuZ2t5dW5rd2FuIFVuaXZlcnNpdHkg

U2Nob29sIG9mIE1lZGljaW5lLCBTZW91bCwgUmVwdWJsaWMgb2YgS29yZWEuJiN4RDtEaXZpc2lv

biBvZiBQdWxtb25hcnkgYW5kIENyaXRpY2FsIENhcmUgTWVkaWNpbmUsIERlcGFydG1lbnQgb2Yg

TWVkaWNpbmUsIFNhbXN1bmcgTWVkaWNhbCBDZW50ZXIsIFN1bmdreXVua3dhbiBVbml2ZXJzaXR5

IFNjaG9vbCBvZiBNZWRpY2luZSwgU2VvdWwsIFJlcHVibGljIG9mIEtvcmVhOyBEZXBhcnRtZW50

IG9mIENyaXRpY2FsIENhcmUgTWVkaWNpbmUsIFNhbXN1bmcgTWVkaWNhbCBDZW50ZXIsIFN1bmdr

eXVua3dhbiBVbml2ZXJzaXR5IFNjaG9vbCBvZiBNZWRpY2luZSwgU2VvdWwsIFJlcHVibGljIG9m

IEtvcmVhLiYjeEQ7RGl2aXNpb24gb2YgUHVsbW9uYXJ5IGFuZCBDcml0aWNhbCBDYXJlIE1lZGlj

aW5lLCBEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBTYW1zdW5nIE1lZGljYWwgQ2VudGVyLCBTdW5n

a3l1bmt3YW4gVW5pdmVyc2l0eSBTY2hvb2wgb2YgTWVkaWNpbmUsIFNlb3VsLCBSZXB1YmxpYyBv

ZiBLb3JlYTsgRGVwYXJ0bWVudCBvZiBDcml0aWNhbCBDYXJlIE1lZGljaW5lLCBTYW1zdW5nIE1l

ZGljYWwgQ2VudGVyLCBTdW5na3l1bmt3YW4gVW5pdmVyc2l0eSBTY2hvb2wgb2YgTWVkaWNpbmUs

IFNlb3VsLCBSZXB1YmxpYyBvZiBLb3JlYS4gRWxlY3Ryb25pYyBhZGRyZXNzOiBramVvbkBza2t1

LmVkdS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5TZXJ1bSBnYWxhY3RvbWFubmFuIGFu

dGlnZW4gdGVzdCBmb3IgdGhlIGRpYWdub3NpcyBvZiBjaHJvbmljIHB1bG1vbmFyeSBhc3Blcmdp

bGxvc2lzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgSW5mZWN0aW9uPC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5UaGUgSm91cm5hbCBvZiBpbmZlY3Rpb248L2FsdC10aXRs

ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIEluZmVjdGlvbjwv

ZnVsbC10aXRsZT48YWJici0xPkogSW5mZWN0PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxwYWdlcz40

OTQtOTwvcGFnZXM+PHZvbHVtZT42ODwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxlZGl0aW9u

PjIwMTQvMDEvMjg8L2VkaXRpb24+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48

ZGF0ZT5NYXk8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTMyLTI3NDIgKEVsZWN0

cm9uaWMpJiN4RDswMTYzLTQ0NTMgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0NDYy

NTYzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTAxNi9qLmppbmYuMjAxNC4wMS4wMDU8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1v

dGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1

YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGluPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj

TnVtPjEyNDU8L1JlY051bT48RGlzcGxheVRleHQ+WzExM108L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+MTI0NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+MTI0NTwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U2hpbiwgQi48L2F1dGhvcj48YXV0aG9y

PktvaCwgVy4gSi48L2F1dGhvcj48YXV0aG9yPkplb25nLCBCLiBILjwvYXV0aG9yPjxhdXRob3I+

WW9vLCBILjwvYXV0aG9yPjxhdXRob3I+UGFyaywgSC4gWS48L2F1dGhvcj48YXV0aG9yPlN1aCwg

Ry4gWS48L2F1dGhvcj48YXV0aG9yPkt3b24sIE8uIEouPC9hdXRob3I+PGF1dGhvcj5KZW9uLCBL

LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRpdmlzaW9u

IG9mIFB1bG1vbmFyeSBhbmQgQ3JpdGljYWwgQ2FyZSBNZWRpY2luZSwgRGVwYXJ0bWVudCBvZiBN

ZWRpY2luZSwgU2Ftc3VuZyBNZWRpY2FsIENlbnRlciwgU3VuZ2t5dW5rd2FuIFVuaXZlcnNpdHkg

U2Nob29sIG9mIE1lZGljaW5lLCBTZW91bCwgUmVwdWJsaWMgb2YgS29yZWEuJiN4RDtEaXZpc2lv

biBvZiBQdWxtb25hcnkgYW5kIENyaXRpY2FsIENhcmUgTWVkaWNpbmUsIERlcGFydG1lbnQgb2Yg

TWVkaWNpbmUsIFNhbXN1bmcgTWVkaWNhbCBDZW50ZXIsIFN1bmdreXVua3dhbiBVbml2ZXJzaXR5

IFNjaG9vbCBvZiBNZWRpY2luZSwgU2VvdWwsIFJlcHVibGljIG9mIEtvcmVhOyBEZXBhcnRtZW50

IG9mIENyaXRpY2FsIENhcmUgTWVkaWNpbmUsIFNhbXN1bmcgTWVkaWNhbCBDZW50ZXIsIFN1bmdr

eXVua3dhbiBVbml2ZXJzaXR5IFNjaG9vbCBvZiBNZWRpY2luZSwgU2VvdWwsIFJlcHVibGljIG9m

IEtvcmVhLiYjeEQ7RGl2aXNpb24gb2YgUHVsbW9uYXJ5IGFuZCBDcml0aWNhbCBDYXJlIE1lZGlj

aW5lLCBEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBTYW1zdW5nIE1lZGljYWwgQ2VudGVyLCBTdW5n

a3l1bmt3YW4gVW5pdmVyc2l0eSBTY2hvb2wgb2YgTWVkaWNpbmUsIFNlb3VsLCBSZXB1YmxpYyBv

ZiBLb3JlYTsgRGVwYXJ0bWVudCBvZiBDcml0aWNhbCBDYXJlIE1lZGljaW5lLCBTYW1zdW5nIE1l

ZGljYWwgQ2VudGVyLCBTdW5na3l1bmt3YW4gVW5pdmVyc2l0eSBTY2hvb2wgb2YgTWVkaWNpbmUs

IFNlb3VsLCBSZXB1YmxpYyBvZiBLb3JlYS4gRWxlY3Ryb25pYyBhZGRyZXNzOiBramVvbkBza2t1

LmVkdS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5TZXJ1bSBnYWxhY3RvbWFubmFuIGFu

dGlnZW4gdGVzdCBmb3IgdGhlIGRpYWdub3NpcyBvZiBjaHJvbmljIHB1bG1vbmFyeSBhc3Blcmdp

bGxvc2lzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgSW5mZWN0aW9uPC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5UaGUgSm91cm5hbCBvZiBpbmZlY3Rpb248L2FsdC10aXRs

ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIEluZmVjdGlvbjwv

ZnVsbC10aXRsZT48YWJici0xPkogSW5mZWN0PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxwYWdlcz40

OTQtOTwvcGFnZXM+PHZvbHVtZT42ODwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxlZGl0aW9u

PjIwMTQvMDEvMjg8L2VkaXRpb24+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48

ZGF0ZT5NYXk8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTMyLTI3NDIgKEVsZWN0

cm9uaWMpJiN4RDswMTYzLTQ0NTMgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0NDYy

NTYzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTAxNi9qLmppbmYuMjAxNC4wMS4wMDU8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1v

dGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1

YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA [113] or chronic obstructive pulmonary disease PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BcXVpbm88L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS

ZWNOdW0+MTI0NjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTE0XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xMjQ2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjQ2PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BcXVpbm8sIFYuIFIuPC9hdXRob3I+

PGF1dGhvcj5OYWdlbCwgRi48L2F1dGhvcj48YXV0aG9yPkFuZHJlb2xsYSwgSC4gRi48L2F1dGhv

cj48YXV0aG9yPmRlLVBhcmlzLCBGLjwvYXV0aG9yPjxhdXRob3I+WGF2aWVyLCBNLiBPLjwvYXV0

aG9yPjxhdXRob3I+R29sZGFuaSwgTC4gWi48L2F1dGhvcj48YXV0aG9yPkRlbm5pbmcsIEQuIFcu

PC9hdXRob3I+PGF1dGhvcj5QYXNxdWFsb3R0bywgQS4gQy48L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Vbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3Jh

bmRlIGRvIFN1bCwgUG9ydG8gQWxlZ3JlLCBCcmF6aWwuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48

dGl0bGU+VGhlIHBlcmZvcm1hbmNlIG9mIHJlYWwtdGltZSBQQ1IsIGdhbGFjdG9tYW5uYW4sIGFu

ZCBmdW5nYWwgY3VsdHVyZSBpbiB0aGUgZGlhZ25vc2lzIG9mIGludmFzaXZlIGFzcGVyZ2lsbG9z

aXMgaW4gdmVudGlsYXRlZCBwYXRpZW50cyB3aXRoIGNocm9uaWMgb2JzdHJ1Y3RpdmUgcHVsbW9u

YXJ5IGRpc2Vhc2UgKENPUEQpPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk15Y29wYXRob2xvZ2lh

PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5NeWNvcGF0aG9sb2dpYTwvYWx0LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk15Y29wYXRob2xvZ2lhPC9mdWxsLXRpdGxl

PjxhYmJyLTE+TXljb3BhdGhvbG9naWE8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPk15Y29wYXRob2xvZ2lhPC9mdWxsLXRpdGxlPjxhYmJyLTE+TXljb3Bh

dGhvbG9naWE8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNjMtOTwvcGFnZXM+PHZv

bHVtZT4xNzQ8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48ZWRpdGlvbj4yMDEyLzAzLzAzPC9l

ZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgw

IGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzIGZ1bWlnYXR1cy8gZ3Jvd3Ro

ICZhbXA7IGRldmVsb3BtZW50LyBpc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3Jk

PjxrZXl3b3JkPkNvaG9ydCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29y

ZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW52YXNpdmUgUHVsbW9uYXJ5IEFz

cGVyZ2lsbG9zaXMvY29tcGxpY2F0aW9ucy8gZGlhZ25vc2lzPC9rZXl3b3JkPjxrZXl3b3JkPk1h

bGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8gYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+

TWljcm9iaW9sb2dpY2FsIFRlY2huaXF1ZXMvIG1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+TWlk

ZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXljb2xvZ3kvIG1ldGhvZHM8L2tleXdvcmQ+PGtl

eXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5QdWxtb25hcnkgRGlz

ZWFzZSwgQ2hyb25pYyBPYnN0cnVjdGl2ZS9jb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3Jk

PlJlYWwtVGltZSBQb2x5bWVyYXNlIENoYWluIFJlYWN0aW9uLyBtZXRob2RzPC9rZXl3b3JkPjwv

a2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWc8L2Rh

dGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTczLTA4MzIgKEVsZWN0cm9uaWMpJiN4RDsw

MzAxLTQ4NlggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyMzgyNzM4PC9hY2Nlc3Np

b24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAwNy9zMTEw

NDYtMDEyLTk1MzEtMTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5n

dWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BcXVpbm88L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS

ZWNOdW0+MTI0NjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTE0XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xMjQ2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjQ2PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BcXVpbm8sIFYuIFIuPC9hdXRob3I+

PGF1dGhvcj5OYWdlbCwgRi48L2F1dGhvcj48YXV0aG9yPkFuZHJlb2xsYSwgSC4gRi48L2F1dGhv

cj48YXV0aG9yPmRlLVBhcmlzLCBGLjwvYXV0aG9yPjxhdXRob3I+WGF2aWVyLCBNLiBPLjwvYXV0

aG9yPjxhdXRob3I+R29sZGFuaSwgTC4gWi48L2F1dGhvcj48YXV0aG9yPkRlbm5pbmcsIEQuIFcu

PC9hdXRob3I+PGF1dGhvcj5QYXNxdWFsb3R0bywgQS4gQy48L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Vbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3Jh

bmRlIGRvIFN1bCwgUG9ydG8gQWxlZ3JlLCBCcmF6aWwuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48

dGl0bGU+VGhlIHBlcmZvcm1hbmNlIG9mIHJlYWwtdGltZSBQQ1IsIGdhbGFjdG9tYW5uYW4sIGFu

ZCBmdW5nYWwgY3VsdHVyZSBpbiB0aGUgZGlhZ25vc2lzIG9mIGludmFzaXZlIGFzcGVyZ2lsbG9z

aXMgaW4gdmVudGlsYXRlZCBwYXRpZW50cyB3aXRoIGNocm9uaWMgb2JzdHJ1Y3RpdmUgcHVsbW9u

YXJ5IGRpc2Vhc2UgKENPUEQpPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk15Y29wYXRob2xvZ2lh

PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5NeWNvcGF0aG9sb2dpYTwvYWx0LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk15Y29wYXRob2xvZ2lhPC9mdWxsLXRpdGxl

PjxhYmJyLTE+TXljb3BhdGhvbG9naWE8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPk15Y29wYXRob2xvZ2lhPC9mdWxsLXRpdGxlPjxhYmJyLTE+TXljb3Bh

dGhvbG9naWE8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNjMtOTwvcGFnZXM+PHZv

bHVtZT4xNzQ8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48ZWRpdGlvbj4yMDEyLzAzLzAzPC9l

ZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgw

IGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzIGZ1bWlnYXR1cy8gZ3Jvd3Ro

ICZhbXA7IGRldmVsb3BtZW50LyBpc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3Jk

PjxrZXl3b3JkPkNvaG9ydCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29y

ZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW52YXNpdmUgUHVsbW9uYXJ5IEFz

cGVyZ2lsbG9zaXMvY29tcGxpY2F0aW9ucy8gZGlhZ25vc2lzPC9rZXl3b3JkPjxrZXl3b3JkPk1h

bGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8gYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+

TWljcm9iaW9sb2dpY2FsIFRlY2huaXF1ZXMvIG1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+TWlk

ZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXljb2xvZ3kvIG1ldGhvZHM8L2tleXdvcmQ+PGtl

eXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5QdWxtb25hcnkgRGlz

ZWFzZSwgQ2hyb25pYyBPYnN0cnVjdGl2ZS9jb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3Jk

PlJlYWwtVGltZSBQb2x5bWVyYXNlIENoYWluIFJlYWN0aW9uLyBtZXRob2RzPC9rZXl3b3JkPjwv

a2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWc8L2Rh

dGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTczLTA4MzIgKEVsZWN0cm9uaWMpJiN4RDsw

MzAxLTQ4NlggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyMzgyNzM4PC9hY2Nlc3Np

b24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAwNy9zMTEw

NDYtMDEyLTk1MzEtMTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5n

dWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [114]. GM in patients with CF colonized with Aspergillus species was consistently negative PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYXJyZW48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS

ZWNOdW0+MTI0NzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTE1XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xMjQ3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjQ3PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5XYXJyZW4sIFQuIEEuPC9hdXRob3I+

PGF1dGhvcj5ZYXUsIFkuPC9hdXRob3I+PGF1dGhvcj5SYXRqZW4sIEYuPC9hdXRob3I+PGF1dGhv

cj5UdWxsaXMsIEUuPC9hdXRob3I+PGF1dGhvcj5XYXRlcnMsIFYuPC9hdXRob3I+PC9hdXRob3Jz

PjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBMYWJvcmF0b3J5IE1l

ZGljaW5lIGFuZCBQYXRob2Jpb2xvZ3ksIFVuaXZlcnNpdHkgb2YgVG9yb250bywgVG9yb250bywg

T250YXJpbywgQ2FuYWRhLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlNlcnVtIGdhbGFj

dG9tYW5uYW4gaW4gY3lzdGljIGZpYnJvc2lzIHBhdGllbnRzIGNvbG9uaXplZCB3aXRoIEFzcGVy

Z2lsbHVzIHNwZWNpZXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TWVkaWNhbCBNeWNvbG9neTwv

c2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+TWVkaWNhbCBteWNvbG9neTwvYWx0LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk1lZGljYWwgTXljb2xvZ3k8L2Z1bGwtdGl0

bGU+PGFiYnItMT5NZWQgTXljb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPk1lZGljYWwgTXljb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5NZWQgTXlj

b2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz42NTgtNjA8L3BhZ2VzPjx2b2x1bWU+

NTA8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48ZWRpdGlvbj4yMDEyLzA0LzI1PC9lZGl0aW9u

PjxrZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9r

ZXl3b3JkPjxrZXl3b3JkPkFudGlnZW5zLCBGdW5nYWwvIGJsb29kPC9rZXl3b3JkPjxrZXl3b3Jk

PkFzcGVyZ2lsbG9zaXMvbWljcm9iaW9sb2d5L3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5B

c3BlcmdpbGx1cyBmdW1pZ2F0dXMvIGlzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb24vcGF0aG9n

ZW5pY2l0eTwva2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5DeXN0aWMg

Rmlicm9zaXMvYmxvb2QvIG1pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tl

eXdvcmQ+PGtleXdvcmQ+Rm9yY2VkIEV4cGlyYXRvcnkgVm9sdW1lPC9rZXl3b3JkPjxrZXl3b3Jk

Pkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9lbnp5bWUgVGVjaG5pcXVlcy9tZXRob2Rz

PC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcvbWljcm9iaW9sb2d5L3BhdGhvbG9neTwva2V5d29yZD48

a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvIGJsb29kPC9rZXl3b3JkPjxr

ZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPllvdW5nIEFkdWx0PC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWc8

L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDYwLTI3MDkgKEVsZWN0cm9uaWMpJiN4

RDsxMzY5LTM3ODYgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyNTI0NjM5PC9hY2Nl

c3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMzEwOS8x

MzY5Mzc4Ni4yMDEyLjY3NjczOTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRh

YmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5n

PC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYXJyZW48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS

ZWNOdW0+MTI0NzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTE1XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xMjQ3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjQ3PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5XYXJyZW4sIFQuIEEuPC9hdXRob3I+

PGF1dGhvcj5ZYXUsIFkuPC9hdXRob3I+PGF1dGhvcj5SYXRqZW4sIEYuPC9hdXRob3I+PGF1dGhv

cj5UdWxsaXMsIEUuPC9hdXRob3I+PGF1dGhvcj5XYXRlcnMsIFYuPC9hdXRob3I+PC9hdXRob3Jz

PjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBMYWJvcmF0b3J5IE1l

ZGljaW5lIGFuZCBQYXRob2Jpb2xvZ3ksIFVuaXZlcnNpdHkgb2YgVG9yb250bywgVG9yb250bywg

T250YXJpbywgQ2FuYWRhLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlNlcnVtIGdhbGFj

dG9tYW5uYW4gaW4gY3lzdGljIGZpYnJvc2lzIHBhdGllbnRzIGNvbG9uaXplZCB3aXRoIEFzcGVy

Z2lsbHVzIHNwZWNpZXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TWVkaWNhbCBNeWNvbG9neTwv

c2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+TWVkaWNhbCBteWNvbG9neTwvYWx0LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk1lZGljYWwgTXljb2xvZ3k8L2Z1bGwtdGl0

bGU+PGFiYnItMT5NZWQgTXljb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPk1lZGljYWwgTXljb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5NZWQgTXlj

b2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz42NTgtNjA8L3BhZ2VzPjx2b2x1bWU+

NTA8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48ZWRpdGlvbj4yMDEyLzA0LzI1PC9lZGl0aW9u

PjxrZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9r

ZXl3b3JkPjxrZXl3b3JkPkFudGlnZW5zLCBGdW5nYWwvIGJsb29kPC9rZXl3b3JkPjxrZXl3b3Jk

PkFzcGVyZ2lsbG9zaXMvbWljcm9iaW9sb2d5L3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5B

c3BlcmdpbGx1cyBmdW1pZ2F0dXMvIGlzb2xhdGlvbiAmYW1wOyBwdXJpZmljYXRpb24vcGF0aG9n

ZW5pY2l0eTwva2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5DeXN0aWMg

Rmlicm9zaXMvYmxvb2QvIG1pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tl

eXdvcmQ+PGtleXdvcmQ+Rm9yY2VkIEV4cGlyYXRvcnkgVm9sdW1lPC9rZXl3b3JkPjxrZXl3b3Jk

Pkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9lbnp5bWUgVGVjaG5pcXVlcy9tZXRob2Rz

PC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcvbWljcm9iaW9sb2d5L3BhdGhvbG9neTwva2V5d29yZD48

a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvIGJsb29kPC9rZXl3b3JkPjxr

ZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPllvdW5nIEFkdWx0PC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWc8

L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDYwLTI3MDkgKEVsZWN0cm9uaWMpJiN4

RDsxMzY5LTM3ODYgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyNTI0NjM5PC9hY2Nl

c3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMzEwOS8x

MzY5Mzc4Ni4yMDEyLjY3NjczOTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRh

YmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5n

PC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [115]. Several variables, including concurrent mould-active antifungal therapy or prophylaxis, significantly reduce levels of circulating GM PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJyPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48UmVj

TnVtPjEyMjk8L1JlY051bT48RGlzcGxheVRleHQ+WzkxLCA5NF08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MTIyOTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+MTIyOTwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFyciwgSy4gQS48L2F1dGhvcj48

YXV0aG9yPkJhbGFqZWUsIFMuIEEuPC9hdXRob3I+PGF1dGhvcj5NY0xhdWdobGluLCBMLjwvYXV0

aG9yPjxhdXRob3I+VGFib3VyZXQsIE0uPC9hdXRob3I+PGF1dGhvcj5CZW50c2VuLCBDLjwvYXV0

aG9yPjxhdXRob3I+V2Fsc2gsIFQuIEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+RnJlZCBIdXRjaGluc29uIENhbmNlciBSZXNlYXJjaCBDZW50ZXIgYW5k

IFVuaXZlcnNpdHkgb2YgV2FzaGluZ3RvbiwgU2VhdHRsZSwgV2FzaGluZ3RvbiA5ODEwOSwgVVNB

LiBrbWFyckBmaGNyYy5vcmc8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EZXRlY3Rpb24g

b2YgZ2FsYWN0b21hbm5hbiBhbnRpZ2VuZW1pYSBieSBlbnp5bWUgaW1tdW5vYXNzYXkgZm9yIHRo

ZSBkaWFnbm9zaXMgb2YgaW52YXNpdmUgYXNwZXJnaWxsb3NpczogdmFyaWFibGVzIHRoYXQgYWZm

ZWN0IHBlcmZvcm1hbmNlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgSW5mZWN0

aW91cyBEaXNlYXNlczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+VGhlIEpvdXJuYWwgb2Yg

aW5mZWN0aW91cyBkaXNlYXNlczwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxs

LXRpdGxlPkpvdXJuYWwgb2YgSW5mZWN0aW91cyBEaXNlYXNlczwvZnVsbC10aXRsZT48YWJici0x

PkogSW5mZWN0IERpczwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+VGhlIEpvdXJuYWwgb2YgSW5mZWN0aW91cyBEaXNlYXNlczwvZnVsbC10aXRsZT48L2Fs

dC1wZXJpb2RpY2FsPjxwYWdlcz42NDEtOTwvcGFnZXM+PHZvbHVtZT4xOTA8L3ZvbHVtZT48bnVt

YmVyPjM8L251bWJlcj48ZWRpdGlvbj4yMDA0LzA3LzEwPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5

d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW5pbWFsczwva2V5d29yZD48a2V5d29yZD5BbnRpZ2Vu

cywgRnVuZ2FsLyBibG9vZDwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzLyBkaWFnbm9z

aXMvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzLyBpc29sYXRpb24g

JmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkJvbmUgTWFycm93IFRyYW5zcGxh

bnRhdGlvbi9hZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+

PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIE1vZGVs

cywgQW5pbWFsPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5GdW5n

ZW1pYS8gZGlhZ25vc2lzL21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+SW1tdW5vZW56eW1lIFRlY2huaXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+

THVuZyBEaXNlYXNlcywgRnVuZ2FsL2RpYWdub3Npcy9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtl

eXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5zLyBibG9vZDwva2V5d29yZD48a2V5

d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5SYWJiaXRzPC9rZXl3b3JkPjxrZXl3

b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDA0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnIDE8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4wMDIyLTE4OTkgKFByaW50KSYjeEQ7MDAyMi0xODk5IChMaW5raW5n

KTwvaXNibj48YWNjZXNzaW9uLW51bT4xNTI0Mzk0MzwvYWNjZXNzaW9uLW51bT48dXJscz48L3Vy

bHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwODYvNDIyMDA5PC9lbGVjdHJvbmljLXJl

c291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNl

LXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48

QXV0aG9yPk1hZXJ0ZW5zPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48UmVjTnVtPjEyMzE8L1Jl

Y051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEyMzE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJwdzA1ZmZzZndyZXgi

PjEyMzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl

Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1hZXJ0ZW5zLCBK

LiBBLjwvYXV0aG9yPjxhdXRob3I+S2xvbnQsIFIuPC9hdXRob3I+PGF1dGhvcj5NYXNzb24sIEMu

PC9hdXRob3I+PGF1dGhvcj5UaGV1bmlzc2VuLCBLLjwvYXV0aG9yPjxhdXRob3I+TWVlcnNzZW1h

biwgVy48L2F1dGhvcj48YXV0aG9yPkxhZ3JvdSwgSy48L2F1dGhvcj48YXV0aG9yPkhlaW5lbiwg

Qy48L2F1dGhvcj48YXV0aG9yPkNyZXBpbiwgQi48L2F1dGhvcj48YXV0aG9yPlZhbiBFbGRlcmUs

IEouPC9hdXRob3I+PGF1dGhvcj5UYWJvdXJldCwgTS48L2F1dGhvcj48YXV0aG9yPkRvbm5lbGx5

LCBKLiBQLjwvYXV0aG9yPjxhdXRob3I+VmVyd2VpaiwgUC4gRS48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIEhlbWF0b2xvZ3ksIFVu

aXZlcnNpdGFpcmUgWmlla2VuaHVpemVuLCBDYXRob2xpYyBVbml2ZXJzaXR5IExldXZlbiwgTGV1

dmVuLCBCZWxnaXVtLiBqb2hhbi5tYWVydGVuc0B1ei5rdWxldXZlbi5hYy5iZTwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPk9wdGltaXphdGlvbiBvZiB0aGUgY3V0b2ZmIHZhbHVlIGZvciB0

aGUgQXNwZXJnaWxsdXMgZG91YmxlLXNhbmR3aWNoIGVuenltZSBpbW11bm9hc3NheTwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5DbGluaWNhbCBpbmZlY3Rpb3VzIGRpc2Vhc2VzIDogYW4gb2ZmaWNp

YWwgcHVibGljYXRpb24gb2YgdGhlIEluZmVjdGlvdXMgRGlzZWFzZXMgU29jaWV0eSBvZiBBbWVy

aWNhPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2xpbmljYWwg

SW5mZWN0aW91cyBEaXNlYXNlczwvZnVsbC10aXRsZT48YWJici0xPkNsaW4gSW5mZWN0IERpczwv

YWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+MTMyOS0zNjwvcGFnZXM+PHZvbHVtZT40NDwvdm9s

dW1lPjxudW1iZXI+MTA8L251bWJlcj48ZWRpdGlvbj4yMDA3LzA0LzIwPC9lZGl0aW9uPjxrZXl3

b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3Jk

PjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9ibG9vZC8gZGlh

Z25vc2lzL21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy8gaXNvbGF0

aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+

PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub2VuenltZSBUZWNobmlxdWVz

LyBtZXRob2RzL3N0YW5kYXJkczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3

b3JkPk1hbm5hbnMvYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdv

cmQ+PGtleXdvcmQ+TmV1dHJvcGVuaWEvaW1tdW5vbG9neS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+Uk9DIEN1cnZlPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGll

czwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+

PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heSAx

NTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzctNjU5MSAoRWxlY3Ryb25pYykm

I3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTc0NDM0NzA8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDg2

LzUxNDM0OTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRl

cj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48

L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJyPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48UmVj

TnVtPjEyMjk8L1JlY051bT48RGlzcGxheVRleHQ+WzkxLCA5NF08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MTIyOTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3JleCI+MTIyOTwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFyciwgSy4gQS48L2F1dGhvcj48

YXV0aG9yPkJhbGFqZWUsIFMuIEEuPC9hdXRob3I+PGF1dGhvcj5NY0xhdWdobGluLCBMLjwvYXV0

aG9yPjxhdXRob3I+VGFib3VyZXQsIE0uPC9hdXRob3I+PGF1dGhvcj5CZW50c2VuLCBDLjwvYXV0

aG9yPjxhdXRob3I+V2Fsc2gsIFQuIEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+RnJlZCBIdXRjaGluc29uIENhbmNlciBSZXNlYXJjaCBDZW50ZXIgYW5k

IFVuaXZlcnNpdHkgb2YgV2FzaGluZ3RvbiwgU2VhdHRsZSwgV2FzaGluZ3RvbiA5ODEwOSwgVVNB

LiBrbWFyckBmaGNyYy5vcmc8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EZXRlY3Rpb24g

b2YgZ2FsYWN0b21hbm5hbiBhbnRpZ2VuZW1pYSBieSBlbnp5bWUgaW1tdW5vYXNzYXkgZm9yIHRo

ZSBkaWFnbm9zaXMgb2YgaW52YXNpdmUgYXNwZXJnaWxsb3NpczogdmFyaWFibGVzIHRoYXQgYWZm

ZWN0IHBlcmZvcm1hbmNlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgSW5mZWN0

aW91cyBEaXNlYXNlczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+VGhlIEpvdXJuYWwgb2Yg

aW5mZWN0aW91cyBkaXNlYXNlczwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxs

LXRpdGxlPkpvdXJuYWwgb2YgSW5mZWN0aW91cyBEaXNlYXNlczwvZnVsbC10aXRsZT48YWJici0x

PkogSW5mZWN0IERpczwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+VGhlIEpvdXJuYWwgb2YgSW5mZWN0aW91cyBEaXNlYXNlczwvZnVsbC10aXRsZT48L2Fs

dC1wZXJpb2RpY2FsPjxwYWdlcz42NDEtOTwvcGFnZXM+PHZvbHVtZT4xOTA8L3ZvbHVtZT48bnVt

YmVyPjM8L251bWJlcj48ZWRpdGlvbj4yMDA0LzA3LzEwPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5

d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk

PkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW5pbWFsczwva2V5d29yZD48a2V5d29yZD5BbnRpZ2Vu

cywgRnVuZ2FsLyBibG9vZDwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzLyBkaWFnbm9z

aXMvbWljcm9iaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzLyBpc29sYXRpb24g

JmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkJvbmUgTWFycm93IFRyYW5zcGxh

bnRhdGlvbi9hZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+

PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIE1vZGVs

cywgQW5pbWFsPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5GdW5n

ZW1pYS8gZGlhZ25vc2lzL21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+SW1tdW5vZW56eW1lIFRlY2huaXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+

THVuZyBEaXNlYXNlcywgRnVuZ2FsL2RpYWdub3Npcy9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtl

eXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5zLyBibG9vZDwva2V5d29yZD48a2V5

d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5SYWJiaXRzPC9rZXl3b3JkPjxrZXl3

b3JkPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDA0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnIDE8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4wMDIyLTE4OTkgKFByaW50KSYjeEQ7MDAyMi0xODk5IChMaW5raW5n

KTwvaXNibj48YWNjZXNzaW9uLW51bT4xNTI0Mzk0MzwvYWNjZXNzaW9uLW51bT48dXJscz48L3Vy

bHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwODYvNDIyMDA5PC9lbGVjdHJvbmljLXJl

c291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNl

LXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48

QXV0aG9yPk1hZXJ0ZW5zPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48UmVjTnVtPjEyMzE8L1Jl

Y051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEyMzE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJwdzA1ZmZzZndyZXgi

PjEyMzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl

Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1hZXJ0ZW5zLCBK

LiBBLjwvYXV0aG9yPjxhdXRob3I+S2xvbnQsIFIuPC9hdXRob3I+PGF1dGhvcj5NYXNzb24sIEMu

PC9hdXRob3I+PGF1dGhvcj5UaGV1bmlzc2VuLCBLLjwvYXV0aG9yPjxhdXRob3I+TWVlcnNzZW1h

biwgVy48L2F1dGhvcj48YXV0aG9yPkxhZ3JvdSwgSy48L2F1dGhvcj48YXV0aG9yPkhlaW5lbiwg

Qy48L2F1dGhvcj48YXV0aG9yPkNyZXBpbiwgQi48L2F1dGhvcj48YXV0aG9yPlZhbiBFbGRlcmUs

IEouPC9hdXRob3I+PGF1dGhvcj5UYWJvdXJldCwgTS48L2F1dGhvcj48YXV0aG9yPkRvbm5lbGx5

LCBKLiBQLjwvYXV0aG9yPjxhdXRob3I+VmVyd2VpaiwgUC4gRS48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIEhlbWF0b2xvZ3ksIFVu

aXZlcnNpdGFpcmUgWmlla2VuaHVpemVuLCBDYXRob2xpYyBVbml2ZXJzaXR5IExldXZlbiwgTGV1

dmVuLCBCZWxnaXVtLiBqb2hhbi5tYWVydGVuc0B1ei5rdWxldXZlbi5hYy5iZTwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPk9wdGltaXphdGlvbiBvZiB0aGUgY3V0b2ZmIHZhbHVlIGZvciB0

aGUgQXNwZXJnaWxsdXMgZG91YmxlLXNhbmR3aWNoIGVuenltZSBpbW11bm9hc3NheTwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5DbGluaWNhbCBpbmZlY3Rpb3VzIGRpc2Vhc2VzIDogYW4gb2ZmaWNp

YWwgcHVibGljYXRpb24gb2YgdGhlIEluZmVjdGlvdXMgRGlzZWFzZXMgU29jaWV0eSBvZiBBbWVy

aWNhPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2xpbmljYWwg

SW5mZWN0aW91cyBEaXNlYXNlczwvZnVsbC10aXRsZT48YWJici0xPkNsaW4gSW5mZWN0IERpczwv

YWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+MTMyOS0zNjwvcGFnZXM+PHZvbHVtZT40NDwvdm9s

dW1lPjxudW1iZXI+MTA8L251bWJlcj48ZWRpdGlvbj4yMDA3LzA0LzIwPC9lZGl0aW9uPjxrZXl3

b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3Jk

PjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9ibG9vZC8gZGlh

Z25vc2lzL21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy8gaXNvbGF0

aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+

PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub2VuenltZSBUZWNobmlxdWVz

LyBtZXRob2RzL3N0YW5kYXJkczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3

b3JkPk1hbm5hbnMvYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdv

cmQ+PGtleXdvcmQ+TmV1dHJvcGVuaWEvaW1tdW5vbG9neS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+Uk9DIEN1cnZlPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGll

czwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+

PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heSAx

NTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzctNjU5MSAoRWxlY3Ryb25pYykm

I3hEOzEwNTgtNDgzOCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTc0NDM0NzA8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDg2

LzUxNDM0OTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRl

cj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48

L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [91, 94]. The GMI may be increased in the setting of neutropenia and decreases in response to antifungal agents. In one study, the GMI in patients with absolute neutrophil count (ANC) <100/ ?l and not receiving antifungal therapy was statistically higher than those patients with an ANC >100/ ?l; however the GMI in patients with an ANC <100/?l and receiving antifungal therapy was not statistically different than those patients with an ANC >100 ?l. Laboratory data and clinical observations indicate that this effect may be due to a higher fungal burden in neutropenic patients, or a more robust inflammatory process in non-neutropenic patients with a corresponding decrease in the burden of disease, rate of dissemination, and GM release PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Db3Jkb25uaWVyPC9BdXRob3I+PFllYXI+MjAwOTwvWWVh

cj48UmVjTnVtPjEwODY8L1JlY051bT48RGlzcGxheVRleHQ+WzExNiwgMTE3XTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xMDg2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4x

MDg2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Db3Jkb25uaWVyLCBD

PC9hdXRob3I+PGF1dGhvcj5Cb3R0ZXJlbCwgRjwvYXV0aG9yPjxhdXRob3I+QmVuIEFtb3IsIFI8

L2F1dGhvcj48YXV0aG9yPlBhdXRhcywgQzwvYXV0aG9yPjxhdXRob3I+TWF1cnksIFM8L2F1dGhv

cj48YXV0aG9yPkt1ZW50eiwgTTwvYXV0aG9yPjxhdXRob3I+SGljaGVyaSwgWTwvYXV0aG9yPjxh

dXRob3I+QmFzdHVqaS1HYXJpbiwgUzwvYXV0aG9yPjxhdXRob3I+QnJldGFnbmUsIFM8L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+Q29ycmVsYXRpb24gYmV0

d2VlbiBnYWxhY3RvbWFubmFuIGFudGlnZW4gbGV2ZWxzIGluIHNlcnVtIGFuZCBuZXV0cm9waGls

IGNvdW50cyBpbiBoYWVtYXRvbG9naWNhbCBwYXRpZW50cyB3aXRoIGludmFzaXZlIGFzcGVyZ2ls

bG9zaXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2xpbmljYWwgTWljcm9iaW9sb2d5IGFuZCBJ

bmZlY3Rpb248L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRs

ZT5DbGluaWNhbCBNaWNyb2Jpb2xvZ3kgYW5kIEluZmVjdGlvbjwvZnVsbC10aXRsZT48YWJici0x

PkNsaW4gTWljcm9iaW9sIEluZmVjdDwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+ODEtNjwv

cGFnZXM+PHZvbHVtZT4xNTwvdm9sdW1lPjxkYXRlcz48eWVhcj4yMDA5PC95ZWFyPjwvZGF0ZXM+

PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlBldHJhaXRpZW5lPC9B

dXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVjTnVtPjYzNzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u

dW1iZXI+NjM3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0i

MjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9IjE0MzkzMTQz

NDYiPjYzNzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGlj

bGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UGV0cmFpdGll

bmUsIFIuPC9hdXRob3I+PGF1dGhvcj5QZXRyYWl0aXMsIFYuPC9hdXRob3I+PGF1dGhvcj5CYWNo

ZXIsIEouIEQuPC9hdXRob3I+PGF1dGhvcj5GaW5rZWxtYW4sIE0uIEEuPC9hdXRob3I+PGF1dGhv

cj5XYWxzaCwgVC4gSi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRk

cmVzcz5UcmFuc3BsYW50YXRpb24tT25jb2xvZ3kgSW5mZWN0aW91cyBEaXNlYXNlcyBQcm9ncmFt

LCBEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBXZWlsbCBDb3JuZWxsIE1lZGljYWwgQ2VudGVyIG9m

IENvcm5lbGwgVW5pdmVyc2l0eSwgTmV3IFlvcmssIE5ldyBZb3JrLCBVU0EgdGh3MjAwM0BtZWQu

Y29ybmVsbC5lZHUgcm9wMjAxNkBtZWQuY29ybmVsbC5lZHUuJiN4RDtUcmFuc3BsYW50YXRpb24t

T25jb2xvZ3kgSW5mZWN0aW91cyBEaXNlYXNlcyBQcm9ncmFtLCBEZXBhcnRtZW50IG9mIE1lZGlj

aW5lLCBXZWlsbCBDb3JuZWxsIE1lZGljYWwgQ2VudGVyIG9mIENvcm5lbGwgVW5pdmVyc2l0eSwg

TmV3IFlvcmssIE5ldyBZb3JrLCBVU0EuJiN4RDtEaXZpc2lvbiBvZiBWZXRlcmluYXJ5IFJlc291

cmNlcywgT2ZmaWNlIG9mIFJlc2VhcmNoIFNlcnZpY2VzLCBOYXRpb25hbCBJbnN0aXR1dGVzIG9m

IEhlYWx0aCwgQmV0aGVzZGEsIE1hcnlsYW5kLCBVU0EuJiN4RDtBc3NvY2lhdGVzIG9mIENhcGUg

Q29kLCBJbmMuLCBFYXN0IEZhbG1vdXRoLCBNYXNzYWNodXNldHRzLCBVU0EuJiN4RDtUcmFuc3Bs

YW50YXRpb24tT25jb2xvZ3kgSW5mZWN0aW91cyBEaXNlYXNlcyBQcm9ncmFtLCBEZXBhcnRtZW50

IG9mIE1lZGljaW5lLCBXZWlsbCBDb3JuZWxsIE1lZGljYWwgQ2VudGVyIG9mIENvcm5lbGwgVW5p

dmVyc2l0eSwgTmV3IFlvcmssIE5ldyBZb3JrLCBVU0EgRGVwYXJ0bWVudHMgb2YgUGVkaWF0cmlj

cyBhbmQgTWljcm9iaW9sb2d5IGFuZCBJbW11bm9sb2d5LCBXZWlsbCBDb3JuZWxsIE1lZGljYWwg

Q29sbGVnZSBvZiBDb3JuZWxsIFVuaXZlcnNpdHksIE5ldyBZb3JrLCBOZXcgWW9yaywgVVNBIHRo

dzIwMDNAbWVkLmNvcm5lbGwuZWR1IHJvcDIwMTZAbWVkLmNvcm5lbGwuZWR1LjwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdHMgb2YgaG9zdCByZXNwb25zZSBhbmQgYW50aWZ1bmdh

bCB0aGVyYXB5IG9uIHNlcnVtIGFuZCBCQUwgbGV2ZWxzIG9mIGdhbGFjdG9tYW5uYW4gYW5kICgx

LS0mZ3Q7MyktYmV0YS1ELWdsdWNhbiBpbiBleHBlcmltZW50YWwgaW52YXNpdmUgcHVsbW9uYXJ5

IGFzcGVyZ2lsbG9zaXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TWVkIE15Y29sPC9zZWNvbmRh

cnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TWVkaWNhbCBNeWNvbG9n

eTwvZnVsbC10aXRsZT48YWJici0xPk1lZC4gTXljb2wuPC9hYmJyLTE+PGFiYnItMj5NZWQgTXlj

b2w8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjU1OC02ODwvcGFnZXM+PHZvbHVtZT41Mzwv

dm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD4oMS0tJmd0OzMpLWJl

dGEtRC1nbHVjYW48L2tleXdvcmQ+PGtleXdvcmQ+YXNwZXJnaWxsb3Npczwva2V5d29yZD48a2V5

d29yZD5nYWxhY3RvbWFubmFuPC9rZXl3b3JkPjxrZXl3b3JkPmltbXVub3N1cHByZXNzaW9uPC9r

ZXl3b3JkPjxrZXl3b3JkPm5ldXRyb3BlbmlhPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5

ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWcgMTwvZGF0ZT48L3B1Yi1kYXRlcz48

L2RhdGVzPjxpc2JuPjE0NjAtMjcwOSAoRWxlY3Ryb25pYykmI3hEOzEzNjktMzc4NiAoTGlua2lu

Zyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjYxMjk4OTA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjYxMjk4

OTA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw

LjEwOTMvbW15L215djAzNDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Db3Jkb25uaWVyPC9BdXRob3I+PFllYXI+MjAwOTwvWWVh

cj48UmVjTnVtPjEwODY8L1JlY051bT48RGlzcGxheVRleHQ+WzExNiwgMTE3XTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xMDg2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4x

MDg2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Db3Jkb25uaWVyLCBD

PC9hdXRob3I+PGF1dGhvcj5Cb3R0ZXJlbCwgRjwvYXV0aG9yPjxhdXRob3I+QmVuIEFtb3IsIFI8

L2F1dGhvcj48YXV0aG9yPlBhdXRhcywgQzwvYXV0aG9yPjxhdXRob3I+TWF1cnksIFM8L2F1dGhv

cj48YXV0aG9yPkt1ZW50eiwgTTwvYXV0aG9yPjxhdXRob3I+SGljaGVyaSwgWTwvYXV0aG9yPjxh

dXRob3I+QmFzdHVqaS1HYXJpbiwgUzwvYXV0aG9yPjxhdXRob3I+QnJldGFnbmUsIFM8L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+Q29ycmVsYXRpb24gYmV0

d2VlbiBnYWxhY3RvbWFubmFuIGFudGlnZW4gbGV2ZWxzIGluIHNlcnVtIGFuZCBuZXV0cm9waGls

IGNvdW50cyBpbiBoYWVtYXRvbG9naWNhbCBwYXRpZW50cyB3aXRoIGludmFzaXZlIGFzcGVyZ2ls

bG9zaXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2xpbmljYWwgTWljcm9iaW9sb2d5IGFuZCBJ

bmZlY3Rpb248L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRs

ZT5DbGluaWNhbCBNaWNyb2Jpb2xvZ3kgYW5kIEluZmVjdGlvbjwvZnVsbC10aXRsZT48YWJici0x

PkNsaW4gTWljcm9iaW9sIEluZmVjdDwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+ODEtNjwv

cGFnZXM+PHZvbHVtZT4xNTwvdm9sdW1lPjxkYXRlcz48eWVhcj4yMDA5PC95ZWFyPjwvZGF0ZXM+

PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlBldHJhaXRpZW5lPC9B

dXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVjTnVtPjYzNzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u

dW1iZXI+NjM3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0i

MjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9IjE0MzkzMTQz

NDYiPjYzNzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGlj

bGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UGV0cmFpdGll

bmUsIFIuPC9hdXRob3I+PGF1dGhvcj5QZXRyYWl0aXMsIFYuPC9hdXRob3I+PGF1dGhvcj5CYWNo

ZXIsIEouIEQuPC9hdXRob3I+PGF1dGhvcj5GaW5rZWxtYW4sIE0uIEEuPC9hdXRob3I+PGF1dGhv

cj5XYWxzaCwgVC4gSi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRk

cmVzcz5UcmFuc3BsYW50YXRpb24tT25jb2xvZ3kgSW5mZWN0aW91cyBEaXNlYXNlcyBQcm9ncmFt

LCBEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBXZWlsbCBDb3JuZWxsIE1lZGljYWwgQ2VudGVyIG9m

IENvcm5lbGwgVW5pdmVyc2l0eSwgTmV3IFlvcmssIE5ldyBZb3JrLCBVU0EgdGh3MjAwM0BtZWQu

Y29ybmVsbC5lZHUgcm9wMjAxNkBtZWQuY29ybmVsbC5lZHUuJiN4RDtUcmFuc3BsYW50YXRpb24t

T25jb2xvZ3kgSW5mZWN0aW91cyBEaXNlYXNlcyBQcm9ncmFtLCBEZXBhcnRtZW50IG9mIE1lZGlj

aW5lLCBXZWlsbCBDb3JuZWxsIE1lZGljYWwgQ2VudGVyIG9mIENvcm5lbGwgVW5pdmVyc2l0eSwg

TmV3IFlvcmssIE5ldyBZb3JrLCBVU0EuJiN4RDtEaXZpc2lvbiBvZiBWZXRlcmluYXJ5IFJlc291

cmNlcywgT2ZmaWNlIG9mIFJlc2VhcmNoIFNlcnZpY2VzLCBOYXRpb25hbCBJbnN0aXR1dGVzIG9m

IEhlYWx0aCwgQmV0aGVzZGEsIE1hcnlsYW5kLCBVU0EuJiN4RDtBc3NvY2lhdGVzIG9mIENhcGUg

Q29kLCBJbmMuLCBFYXN0IEZhbG1vdXRoLCBNYXNzYWNodXNldHRzLCBVU0EuJiN4RDtUcmFuc3Bs

YW50YXRpb24tT25jb2xvZ3kgSW5mZWN0aW91cyBEaXNlYXNlcyBQcm9ncmFtLCBEZXBhcnRtZW50

IG9mIE1lZGljaW5lLCBXZWlsbCBDb3JuZWxsIE1lZGljYWwgQ2VudGVyIG9mIENvcm5lbGwgVW5p

dmVyc2l0eSwgTmV3IFlvcmssIE5ldyBZb3JrLCBVU0EgRGVwYXJ0bWVudHMgb2YgUGVkaWF0cmlj

cyBhbmQgTWljcm9iaW9sb2d5IGFuZCBJbW11bm9sb2d5LCBXZWlsbCBDb3JuZWxsIE1lZGljYWwg

Q29sbGVnZSBvZiBDb3JuZWxsIFVuaXZlcnNpdHksIE5ldyBZb3JrLCBOZXcgWW9yaywgVVNBIHRo

dzIwMDNAbWVkLmNvcm5lbGwuZWR1IHJvcDIwMTZAbWVkLmNvcm5lbGwuZWR1LjwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdHMgb2YgaG9zdCByZXNwb25zZSBhbmQgYW50aWZ1bmdh

bCB0aGVyYXB5IG9uIHNlcnVtIGFuZCBCQUwgbGV2ZWxzIG9mIGdhbGFjdG9tYW5uYW4gYW5kICgx

LS0mZ3Q7MyktYmV0YS1ELWdsdWNhbiBpbiBleHBlcmltZW50YWwgaW52YXNpdmUgcHVsbW9uYXJ5

IGFzcGVyZ2lsbG9zaXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TWVkIE15Y29sPC9zZWNvbmRh

cnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TWVkaWNhbCBNeWNvbG9n

eTwvZnVsbC10aXRsZT48YWJici0xPk1lZC4gTXljb2wuPC9hYmJyLTE+PGFiYnItMj5NZWQgTXlj

b2w8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjU1OC02ODwvcGFnZXM+PHZvbHVtZT41Mzwv

dm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD4oMS0tJmd0OzMpLWJl

dGEtRC1nbHVjYW48L2tleXdvcmQ+PGtleXdvcmQ+YXNwZXJnaWxsb3Npczwva2V5d29yZD48a2V5

d29yZD5nYWxhY3RvbWFubmFuPC9rZXl3b3JkPjxrZXl3b3JkPmltbXVub3N1cHByZXNzaW9uPC9r

ZXl3b3JkPjxrZXl3b3JkPm5ldXRyb3BlbmlhPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5

ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWcgMTwvZGF0ZT48L3B1Yi1kYXRlcz48

L2RhdGVzPjxpc2JuPjE0NjAtMjcwOSAoRWxlY3Ryb25pYykmI3hEOzEzNjktMzc4NiAoTGlua2lu

Zyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjYxMjk4OTA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjYxMjk4

OTA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw

LjEwOTMvbW15L215djAzNDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA [116, 117].False-positive results have been reported in several contexts, including in patients who have received certain antibiotics (historically most notably piperacillin-tazobactam, which appears now to no longer be cross-reactive PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WZXJnaWRpczwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+

PFJlY051bT42Mzg8L1JlY051bT48RGlzcGxheVRleHQ+WzExOF08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+NjM4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9

IjE0MzkzMTQ1NjIiPjYzODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

VmVyZ2lkaXMsIFAuPC9hdXRob3I+PGF1dGhvcj5SYXpvbmFibGUsIFIuIFIuPC9hdXRob3I+PGF1

dGhvcj5XaGVhdCwgTC4gSi48L2F1dGhvcj48YXV0aG9yPkVzdGVzLCBMLjwvYXV0aG9yPjxhdXRo

b3I+Q2FsaWVuZG8sIEEuIE0uPC9hdXRob3I+PGF1dGhvcj5CYWRlbiwgTC4gUi48L2F1dGhvcj48

YXV0aG9yPldpbmdhcmQsIEouIFIuPC9hdXRob3I+PGF1dGhvcj5CYWRkbGV5LCBKLjwvYXV0aG9y

PjxhdXRob3I+QXNzaSwgTS48L2F1dGhvcj48YXV0aG9yPk5vcnJpcywgUy48L2F1dGhvcj48YXV0

aG9yPkNoYW5kcmFzZWthciwgUC48L2F1dGhvcj48YXV0aG9yPlNoaWVsZHMsIFIuPC9hdXRob3I+

PGF1dGhvcj5OZ3V5ZW4sIEguPC9hdXRob3I+PGF1dGhvcj5GcmVpZmVsZCwgQS48L2F1dGhvcj48

YXV0aG9yPktvaGxlciwgUi48L2F1dGhvcj48YXV0aG9yPktsZWltYW4sIE0uPC9hdXRob3I+PGF1

dGhvcj5XYWxzaCwgVC4gSi48L2F1dGhvcj48YXV0aG9yPkhhZ2UsIEMuIEEuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+TWF5byBDbGluaWMgQ29sbGVnZSBv

ZiBNZWRpY2luZSwgUm9jaGVzdGVyLCBNaW5uZXNvdGEsIFVTQS4mI3hEO01pcmFWaXN0YSBEaWFn

bm9zdGljcyBhbmQgTWlyYWJlbGxhIFRlY2hub2xvZ2llcywgSW5kaWFuYXBvbGlzLCBJbmRpYW5h

LCBVU0EuJiN4RDtBbHBlcnQgTWVkaWNhbCBTY2hvb2wgb2YgQnJvd24gVW5pdmVyc2l0eSwgUHJv

dmlkZW5jZSwgUmhvZGUgSXNsYW5kLCBVU0EuJiN4RDtCcmlnaGFtIGFuZCBXb21lbiZhcG9zO3Mg

SG9zcGl0YWwsIEJvc3RvbiwgTWFzc2FjaHVzZXR0cywgVVNBLiYjeEQ7VW5pdmVyc2l0eSBvZiBG

bG9yaWRhLCBDb2xsZWdlIG9mIE1lZGljaW5lLCBHYWluZXN2aWxsZSwgRmxvcmlkYSwgVVNBLiYj

eEQ7VW5pdmVyc2l0eSBvZiBBbGFiYW1hLCBCaXJtaW5naGFtLCBBbGFiYW1hLCBVU0EuJiN4RDtV

bml2ZXJzaXR5IG9mIEthbnNhcyBTY2hvb2wgb2YgTWVkaWNpbmUsIFdpY2hpdGEsIEthbnNhcywg

VVNBLiYjeEQ7Q29tbXVuaXR5IEluZmVjdGlvdXMgRGlzZWFzZXMsIEluZGlhbmFwb2xpcywgSW5k

aWFuYSwgVVNBLiYjeEQ7V2F5bmUgU3RhdGUgVW5pdmVyc2l0eSwgRGV0cm9pdCwgTWljaGlnYW4s

IFVTQS4mI3hEO1VuaXZlcnNpdHkgb2YgUGl0dHNidXJnaCBTY2hvb2wgb2YgTWVkaWNpbmUsIFBp

dHRzYnVyZ2gsIFBlbm5zeWx2YW5pYSwgVVNBLiYjeEQ7VW5pdmVyc2l0eSBvZiBOZWJyYXNrYSBN

ZWRpY2FsIENlbnRlciwgT21haGEsIE5lYnJhc2thLCBVU0EuJiN4RDtJbmRpYW5hIFVuaXZlcnNp

dHksIEluZmVjdGlvdXMgRGlzZWFzZXMsIFdpc2hhcmQgTWVtb3JpYWwgSG9zcGl0YWwsIEluZGlh

bmFwb2xpcywgSW5kaWFuYSwgVVNBLiYjeEQ7SW5kaWFuYSBVbml2ZXJzaXR5LCBQZWRpYXRyaWMg

SW5mZWN0aW91cyBEaXNlYXNlcywgUmlsZXkgTWVtb3JpYWwgSG9zcGl0YWwsIEluZGlhbmFwb2xp

cywgSW5kaWFuYSwgVVNBLiYjeEQ7V2VpbGwgQ29ybmVsbCBNZWRpY2FsIENlbnRlciwgTmV3IFlv

cmssIE5ldyBZb3JrLCBVU0EuJiN4RDtJbmRpYW5hIFVuaXZlcnNpdHksIFRob3JhY2ljIFRyYW5z

cGxhbnRhdGlvbiBQcm9ncmFtLCBJbmRpYW5hcG9saXMsIEluZGlhbmEsIFVTQSBjaGFnZUBpdS5l

ZHUuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UmVkdWN0aW9uIGluIGZhbHNlLXBvc2l0

aXZlIEFzcGVyZ2lsbHVzIHNlcnVtIGdhbGFjdG9tYW5uYW4gZW56eW1lIGltbXVub2Fzc2F5IHJl

c3VsdHMgYXNzb2NpYXRlZCB3aXRoIHVzZSBvZiBwaXBlcmFjaWxsaW4tdGF6b2JhY3RhbSBpbiB0

aGUgVW5pdGVkIFN0YXRlczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIENsaW4gTWljcm9iaW9s

PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5h

bCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KLiBDbGluLiBN

aWNyb2Jpb2wuPC9hYmJyLTE+PGFiYnItMj5KIENsaW4gTWljcm9iaW9sPC9hYmJyLTI+PC9wZXJp

b2RpY2FsPjxwYWdlcz4yMTk5LTIwMTwvcGFnZXM+PHZvbHVtZT41Mjwvdm9sdW1lPjxudW1iZXI+

NjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48

a2V5d29yZD5BbnRpLUJhY3RlcmlhbCBBZ2VudHMvY2hlbWlzdHJ5Lyp0aGVyYXBldXRpYyB1c2U8

L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzPC9rZXl3b3JkPjxrZXl3

b3JkPkFzcGVyZ2lsbHVzLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3JkPjxr

ZXl3b3JkPkRpYWdub3N0aWMgVGVzdHMsIFJvdXRpbmUvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdv

cmQ+RHJ1ZyBDb250YW1pbmF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPipGYWxzZSBQb3NpdGl2ZSBS

ZWFjdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFu

czwva2V5d29yZD48a2V5d29yZD5JbW11bm9lbnp5bWUgVGVjaG5pcXVlcy9tZXRob2RzPC9rZXl3

b3JkPjxrZXl3b3JkPk1hbm5hbnMvKmJsb29kPC9rZXl3b3JkPjxrZXl3b3JkPlBlbmljaWxsYW5p

YyBBY2lkL2FuYWxvZ3MgJmFtcDsgZGVyaXZhdGl2ZXMvY2hlbWlzdHJ5L3RoZXJhcGV1dGljIHVz

ZTwva2V5d29yZD48a2V5d29yZD5QaXBlcmFjaWxsaW4vY2hlbWlzdHJ5L3RoZXJhcGV1dGljIHVz

ZTwva2V5d29yZD48a2V5d29yZD5TZXJ1bS8qY2hlbWlzdHJ5PC9rZXl3b3JkPjxrZXl3b3JkPlVu

aXRlZCBTdGF0ZXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48

cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwOTgt

NjYwWCAoRWxlY3Ryb25pYykmI3hEOzAwOTUtMTEzNyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MjQ3MTk0MzQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjQ3MTk0MzQ8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PGN1c3RvbTI+UE1DNDA0Mjc5MzwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTEyOC9KQ00uMDAyODUtMTQ8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WZXJnaWRpczwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+

PFJlY051bT42Mzg8L1JlY051bT48RGlzcGxheVRleHQ+WzExOF08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+NjM4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9

IjE0MzkzMTQ1NjIiPjYzODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

VmVyZ2lkaXMsIFAuPC9hdXRob3I+PGF1dGhvcj5SYXpvbmFibGUsIFIuIFIuPC9hdXRob3I+PGF1

dGhvcj5XaGVhdCwgTC4gSi48L2F1dGhvcj48YXV0aG9yPkVzdGVzLCBMLjwvYXV0aG9yPjxhdXRo

b3I+Q2FsaWVuZG8sIEEuIE0uPC9hdXRob3I+PGF1dGhvcj5CYWRlbiwgTC4gUi48L2F1dGhvcj48

YXV0aG9yPldpbmdhcmQsIEouIFIuPC9hdXRob3I+PGF1dGhvcj5CYWRkbGV5LCBKLjwvYXV0aG9y

PjxhdXRob3I+QXNzaSwgTS48L2F1dGhvcj48YXV0aG9yPk5vcnJpcywgUy48L2F1dGhvcj48YXV0

aG9yPkNoYW5kcmFzZWthciwgUC48L2F1dGhvcj48YXV0aG9yPlNoaWVsZHMsIFIuPC9hdXRob3I+

PGF1dGhvcj5OZ3V5ZW4sIEguPC9hdXRob3I+PGF1dGhvcj5GcmVpZmVsZCwgQS48L2F1dGhvcj48

YXV0aG9yPktvaGxlciwgUi48L2F1dGhvcj48YXV0aG9yPktsZWltYW4sIE0uPC9hdXRob3I+PGF1

dGhvcj5XYWxzaCwgVC4gSi48L2F1dGhvcj48YXV0aG9yPkhhZ2UsIEMuIEEuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+TWF5byBDbGluaWMgQ29sbGVnZSBv

ZiBNZWRpY2luZSwgUm9jaGVzdGVyLCBNaW5uZXNvdGEsIFVTQS4mI3hEO01pcmFWaXN0YSBEaWFn

bm9zdGljcyBhbmQgTWlyYWJlbGxhIFRlY2hub2xvZ2llcywgSW5kaWFuYXBvbGlzLCBJbmRpYW5h

LCBVU0EuJiN4RDtBbHBlcnQgTWVkaWNhbCBTY2hvb2wgb2YgQnJvd24gVW5pdmVyc2l0eSwgUHJv

dmlkZW5jZSwgUmhvZGUgSXNsYW5kLCBVU0EuJiN4RDtCcmlnaGFtIGFuZCBXb21lbiZhcG9zO3Mg

SG9zcGl0YWwsIEJvc3RvbiwgTWFzc2FjaHVzZXR0cywgVVNBLiYjeEQ7VW5pdmVyc2l0eSBvZiBG

bG9yaWRhLCBDb2xsZWdlIG9mIE1lZGljaW5lLCBHYWluZXN2aWxsZSwgRmxvcmlkYSwgVVNBLiYj

eEQ7VW5pdmVyc2l0eSBvZiBBbGFiYW1hLCBCaXJtaW5naGFtLCBBbGFiYW1hLCBVU0EuJiN4RDtV

bml2ZXJzaXR5IG9mIEthbnNhcyBTY2hvb2wgb2YgTWVkaWNpbmUsIFdpY2hpdGEsIEthbnNhcywg

VVNBLiYjeEQ7Q29tbXVuaXR5IEluZmVjdGlvdXMgRGlzZWFzZXMsIEluZGlhbmFwb2xpcywgSW5k

aWFuYSwgVVNBLiYjeEQ7V2F5bmUgU3RhdGUgVW5pdmVyc2l0eSwgRGV0cm9pdCwgTWljaGlnYW4s

IFVTQS4mI3hEO1VuaXZlcnNpdHkgb2YgUGl0dHNidXJnaCBTY2hvb2wgb2YgTWVkaWNpbmUsIFBp

dHRzYnVyZ2gsIFBlbm5zeWx2YW5pYSwgVVNBLiYjeEQ7VW5pdmVyc2l0eSBvZiBOZWJyYXNrYSBN

ZWRpY2FsIENlbnRlciwgT21haGEsIE5lYnJhc2thLCBVU0EuJiN4RDtJbmRpYW5hIFVuaXZlcnNp

dHksIEluZmVjdGlvdXMgRGlzZWFzZXMsIFdpc2hhcmQgTWVtb3JpYWwgSG9zcGl0YWwsIEluZGlh

bmFwb2xpcywgSW5kaWFuYSwgVVNBLiYjeEQ7SW5kaWFuYSBVbml2ZXJzaXR5LCBQZWRpYXRyaWMg

SW5mZWN0aW91cyBEaXNlYXNlcywgUmlsZXkgTWVtb3JpYWwgSG9zcGl0YWwsIEluZGlhbmFwb2xp

cywgSW5kaWFuYSwgVVNBLiYjeEQ7V2VpbGwgQ29ybmVsbCBNZWRpY2FsIENlbnRlciwgTmV3IFlv

cmssIE5ldyBZb3JrLCBVU0EuJiN4RDtJbmRpYW5hIFVuaXZlcnNpdHksIFRob3JhY2ljIFRyYW5z

cGxhbnRhdGlvbiBQcm9ncmFtLCBJbmRpYW5hcG9saXMsIEluZGlhbmEsIFVTQSBjaGFnZUBpdS5l

ZHUuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UmVkdWN0aW9uIGluIGZhbHNlLXBvc2l0

aXZlIEFzcGVyZ2lsbHVzIHNlcnVtIGdhbGFjdG9tYW5uYW4gZW56eW1lIGltbXVub2Fzc2F5IHJl

c3VsdHMgYXNzb2NpYXRlZCB3aXRoIHVzZSBvZiBwaXBlcmFjaWxsaW4tdGF6b2JhY3RhbSBpbiB0

aGUgVW5pdGVkIFN0YXRlczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIENsaW4gTWljcm9iaW9s

PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5h

bCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KLiBDbGluLiBN

aWNyb2Jpb2wuPC9hYmJyLTE+PGFiYnItMj5KIENsaW4gTWljcm9iaW9sPC9hYmJyLTI+PC9wZXJp

b2RpY2FsPjxwYWdlcz4yMTk5LTIwMTwvcGFnZXM+PHZvbHVtZT41Mjwvdm9sdW1lPjxudW1iZXI+

NjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48

a2V5d29yZD5BbnRpLUJhY3RlcmlhbCBBZ2VudHMvY2hlbWlzdHJ5Lyp0aGVyYXBldXRpYyB1c2U8

L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzPC9rZXl3b3JkPjxrZXl3

b3JkPkFzcGVyZ2lsbHVzLyppc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3JkPjxr

ZXl3b3JkPkRpYWdub3N0aWMgVGVzdHMsIFJvdXRpbmUvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdv

cmQ+RHJ1ZyBDb250YW1pbmF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPipGYWxzZSBQb3NpdGl2ZSBS

ZWFjdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFu

czwva2V5d29yZD48a2V5d29yZD5JbW11bm9lbnp5bWUgVGVjaG5pcXVlcy9tZXRob2RzPC9rZXl3

b3JkPjxrZXl3b3JkPk1hbm5hbnMvKmJsb29kPC9rZXl3b3JkPjxrZXl3b3JkPlBlbmljaWxsYW5p

YyBBY2lkL2FuYWxvZ3MgJmFtcDsgZGVyaXZhdGl2ZXMvY2hlbWlzdHJ5L3RoZXJhcGV1dGljIHVz

ZTwva2V5d29yZD48a2V5d29yZD5QaXBlcmFjaWxsaW4vY2hlbWlzdHJ5L3RoZXJhcGV1dGljIHVz

ZTwva2V5d29yZD48a2V5d29yZD5TZXJ1bS8qY2hlbWlzdHJ5PC9rZXl3b3JkPjxrZXl3b3JkPlVu

aXRlZCBTdGF0ZXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48

cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwOTgt

NjYwWCAoRWxlY3Ryb25pYykmI3hEOzAwOTUtMTEzNyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv

bi1udW0+MjQ3MTk0MzQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjQ3MTk0MzQ8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PGN1c3RvbTI+UE1DNDA0Mjc5MzwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+MTAuMTEyOC9KQ00uMDAyODUtMTQ8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [118], and amoxicillin-clavulanate), neonatal colonization with Bifidobacterium, when Plasmalyte is used in BAL fluids, and in patients with other invasive mycoses (including penicilliosis, fusariosis, histoplasmosis and blastomycosis) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZW5uaW5rLUtlcnN0ZW48L0F1dGhvcj48WWVhcj4yMDA1

PC9ZZWFyPjxSZWNOdW0+MTI1MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTE5LTEyMl08L0Rpc3Bs

YXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTI1MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3Jl

eCI+MTI1MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGlj

bGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWVubmluay1L

ZXJzdGVuLCBNLiBBLjwvYXV0aG9yPjxhdXRob3I+UnVlZ2VicmluaywgRC48L2F1dGhvcj48YXV0

aG9yPktsb250LCBSLiBSLjwvYXV0aG9yPjxhdXRob3I+V2FycmlzLCBBLjwvYXV0aG9yPjxhdXRo

b3I+R2F2aW5pLCBGLjwvYXV0aG9yPjxhdXRob3I+T3AgZGVuIENhbXAsIEguIEouPC9hdXRob3I+

PGF1dGhvcj5WZXJ3ZWlqLCBQLiBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgTWVkaWNhbCBNaWNyb2Jpb2xvZ3ksIFJhZGJvdWQg

VW5pdmVyc2l0eSBOaWptZWdlbiBNZWRpY2FsIENlbnRlciwgUC5PLiBCb3ggOTEwMSwgNjUwMCBI

QiBOaWptZWdlbiwgVGhlIE5ldGhlcmxhbmRzLiBtLm1lbm5pbmtAbW1iLnVtY24ubmw8L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5CaWZpZG9iYWN0ZXJpYWwgbGlwb2dseWNhbiBhcyBhIG5l

dyBjYXVzZSBmb3IgZmFsc2UtcG9zaXRpdmUgcGxhdGVsaWEgQXNwZXJnaWxsdXMgZW56eW1lLWxp

bmtlZCBpbW11bm9zb3JiZW50IGFzc2F5IHJlYWN0aXZpdHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0

LXRpdGxlPkpvdXJuYWwgb2YgY2xpbmljYWwgbWljcm9iaW9sb2d5PC9hbHQtdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xv

Z3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIENsaW4gTWljcm9iaW9sPC9hYmJyLTE+PC9wZXJpb2Rp

Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE1pY3Jv

YmlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkogQ2xpbiBNaWNyb2Jpb2w8L2FiYnItMT48L2Fs

dC1wZXJpb2RpY2FsPjxwYWdlcz4zOTI1LTMxPC9wYWdlcz48dm9sdW1lPjQzPC92b2x1bWU+PG51

bWJlcj44PC9udW1iZXI+PGVkaXRpb24+MjAwNS8wOC8wNjwvZWRpdGlvbj48a2V5d29yZHM+PGtl

eXdvcmQ+QW50aWdlbnMsIEZ1bmdhbC8gYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJn

aWxsb3Npcy8gZGlhZ25vc2lzPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzLyBpbW11bm9s

b2d5PC9rZXl3b3JkPjxrZXl3b3JkPkJpZmlkb2JhY3Rlcml1bS8gaW1tdW5vbG9neTwva2V5d29y

ZD48a2V5d29yZD5Dcm9zcyBSZWFjdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+RW56eW1lLUxpbmtl

ZCBJbW11bm9zb3JiZW50IEFzc2F5PC9rZXl3b3JkPjxrZXl3b3JkPkZhbHNlIFBvc2l0aXZlIFJl

YWN0aW9uczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5mYW50

LCBOZXdib3JuPC9rZXl3b3JkPjxrZXl3b3JkPkxpcG9wb2x5c2FjY2hhcmlkZXMvIGltbXVub2xv

Z3k8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNTwveWVhcj48cHViLWRhdGVz

PjxkYXRlPkF1ZzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwOTUtMTEzNyAoUHJp

bnQpJiN4RDswMDk1LTExMzcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE2MDgxOTMy

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48Y3VzdG9tMj4xMjMzOTc5PC9jdXN0b20yPjxl

bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTI4L2pjbS40My44LjM5MjUtMzkzMS4yMDA1PC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVt

b3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPlN1bGFoaWFuPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48UmVj

TnVtPjEyNTI8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEyNTI8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJw

dzA1ZmZzZndyZXgiPjEyNTI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PlN1bGFoaWFuLCBBLjwvYXV0aG9yPjxhdXRob3I+VG91cmF0aWVyLCBTLjwvYXV0aG9yPjxhdXRo

b3I+UmliYXVkLCBQLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0

aXRsZT5GYWxzZSBwb3NpdGl2ZSB0ZXN0IGZvciBhc3BlcmdpbGx1cyBhbnRpZ2VuZW1pYSByZWxh

dGVkIHRvIGNvbmNvbWl0YW50IGFkbWluaXN0cmF0aW9uIG9mIHBpcGVyYWNpbGxpbiBhbmQgdGF6

b2JhY3RhbTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1l

ZGljaW5lPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5UaGUgTmV3IEVuZ2xhbmQgam91cm5h

bCBvZiBtZWRpY2luZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl

Pk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVu

Z2wgSiBNZWQ8L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjIzNjYtNzwvcGFnZXM+PHZvbHVt

ZT4zNDk8L3ZvbHVtZT48bnVtYmVyPjI0PC9udW1iZXI+PGVkaXRpb24+MjAwMy8xMi8xMjwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW50aWdlbnMsIEZ1bmdhbC8gYmxvb2Q8L2tleXdvcmQ+

PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJn

aWxsdXMvIGltbXVub2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Q3Jvc3MgUmVhY3Rpb25zPC9rZXl3

b3JkPjxrZXl3b3JkPkRydWcgVGhlcmFweSwgQ29tYmluYXRpb24vaW1tdW5vbG9neS8gdGhlcmFw

ZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkZhbHNlIFBvc2l0aXZlIFJlYWN0aW9uczwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8gYmxvb2QvaW1t

dW5vbG9neTwva2V5d29yZD48a2V5d29yZD5QZW5pY2lsbGFuaWMgQWNpZC8gYW5hbG9ncyAmYW1w

OyBkZXJpdmF0aXZlcy9pbW11bm9sb2d5LyB0aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdv

cmQ+UGlwZXJhY2lsbGluL2ltbXVub2xvZ3kvIHRoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5

d29yZD5iZXRhLUxhY3RhbWFzZXMvYW50YWdvbmlzdHMgJmFtcDsgaW5oaWJpdG9yczwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RGVj

IDExPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzMy00NDA2IChFbGVjdHJvbmlj

KSYjeEQ7MDAyOC00NzkzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xNDY2ODQ3Mjwv

YWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEw

NTYvbmVqbTIwMDMxMjExMzQ5MjQyNDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1k

YXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+

ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NZW5uaW5rLUtlcnN0

ZW48L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxSZWNOdW0+ODE0PC9SZWNOdW0+PHJlY29yZD48

cmVjLW51bWJlcj44MTQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1

NDM3MzcwMiI+ODE0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NZW5u

aW5rLUtlcnN0ZW4sIE0uIEEuPC9hdXRob3I+PGF1dGhvcj5Eb25uZWxseSwgSi4gUC48L2F1dGhv

cj48YXV0aG9yPlZlcndlaWosIFAuIEUuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBNZWRpY2FsIE1pY3JvYmlvbG9neSwgVW5pdmVy

c2l0eSBNZWRpY2FsIENlbnRlciBTdCBSYWRib3VkLCBOaWppbWVnZW4sIFRoZSBOZXRoZXJsYW5k

cy48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EZXRlY3Rpb24gb2YgY2lyY3VsYXRpbmcg

Z2FsYWN0b21hbm5hbiBmb3IgdGhlIGRpYWdub3NpcyBhbmQgbWFuYWdlbWVudCBvZiBpbnZhc2l2

ZSBhc3BlcmdpbGxvc2lzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkxhbmNldCBJbmZlY3QgRGlz

PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TGFuY2V0

IEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5MYW5jZXQgSW5mZWN0LiBE

aXMuPC9hYmJyLTE+PGFiYnItMj5MYW5jZXQgSW5mZWN0IERpczwvYWJici0yPjwvcGVyaW9kaWNh

bD48cGFnZXM+MzQ5LTU3PC9wYWdlcz48dm9sdW1lPjQ8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJl

cj48a2V5d29yZHM+PGtleXdvcmQ+QW50aWdlbnMsIEZ1bmdhbC9hbmFseXNpczwva2V5d29yZD48

a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2Jsb29kLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+

QXNwZXJnaWxsdXMvaW1tdW5vbG9neTwva2V5d29yZD48a2V5d29yZD5CaW9tYXJrZXJzL2Jsb29k

PC9rZXl3b3JkPjxrZXl3b3JkPkVuenltZS1MaW5rZWQgSW1tdW5vc29yYmVudCBBc3NheTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8qYmxvb2Q8L2tl

eXdvcmQ+PGtleXdvcmQ+UmVhZ2VudCBLaXRzLCBEaWFnbm9zdGljPC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMDQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdW48L2RhdGU+PC9w

dWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDczLTMwOTkgKFByaW50KSYjeEQ7MTQ3My0zMDk5IChM

aW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xNTE3MjM0MzwvYWNjZXNzaW9uLW51bT48dXJs

cz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8x

NTE3MjM0MzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTAxNi9TMTQ3My0zMDk5KDA0KTAxMDQ1LVg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt

PjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPk1lbm5pbmstS2Vyc3RlbjwvQXV0aG9yPjxZ

ZWFyPjIwMDQ8L1llYXI+PFJlY051bT44MTU8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjgx

NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjI1d3M5OXJm

bncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDU0MzczNzYyIj44MTU8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1lbm5pbmstS2Vyc3Rlbiwg

TS4gQS48L2F1dGhvcj48YXV0aG9yPktsb250LCBSLiBSLjwvYXV0aG9yPjxhdXRob3I+V2Fycmlz

LCBBLjwvYXV0aG9yPjxhdXRob3I+T3AgZGVuIENhbXAsIEguIEouPC9hdXRob3I+PGF1dGhvcj5W

ZXJ3ZWlqLCBQLiBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPkRlcGFydG1lbnQgb2YgTWVkaWNhbCBNaWNyb2Jpb2xvZ3ksIFVuaXZlcnNpdHkgTWVkaWNh

bCBDZW50cmUgTmlqbWVnZW4sIE5ldGhlcmxhbmQuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0

bGU+QmlmaWRvYmFjdGVyaXVtIGxpcG90ZWljaG9pYyBhY2lkIGFuZCBmYWxzZSBFTElTQSByZWFj

dGl2aXR5IGluIGFzcGVyZ2lsbHVzIGFudGlnZW4gZGV0ZWN0aW9uPC90aXRsZT48c2Vjb25kYXJ5

LXRpdGxlPkxhbmNldDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxs

LXRpdGxlPkxhbmNldDwvZnVsbC10aXRsZT48YWJici0xPkxhbmNldDwvYWJici0xPjxhYmJyLTI+

TGFuY2V0PC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz4zMjUtNzwvcGFnZXM+PHZvbHVtZT4z

NjM8L3ZvbHVtZT48bnVtYmVyPjk0MDU8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QW50aWJv

ZGllcywgTW9ub2Nsb25hbC9pbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFudGlnZW5zLCBG

dW5nYWwvKmltbXVub2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kaWFnbm9z

aXMvaW1tdW5vbG9neTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy9ncm93dGggJmFtcDsg

ZGV2ZWxvcG1lbnQvKmltbXVub2xvZ3kvbWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5CaWZp

ZG9iYWN0ZXJpdW0vZ3Jvd3RoICZhbXA7IGRldmVsb3BtZW50LyptZXRhYm9saXNtPC9rZXl3b3Jk

PjxrZXl3b3JkPkNyb3NzIFJlYWN0aW9ucy9pbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkVu

enltZS1MaW5rZWQgSW1tdW5vc29yYmVudCBBc3NheS8qc3RhdGlzdGljcyAmYW1wOyBudW1lcmlj

YWwgZGF0YTwva2V5d29yZD48a2V5d29yZD5FcGl0b3Blcy9pbW11bm9sb2d5PC9rZXl3b3JkPjxr

ZXl3b3JkPkZhbHNlIE5lZ2F0aXZlIFJlYWN0aW9uczwva2V5d29yZD48a2V5d29yZD5GYWxzZSBQ

b3NpdGl2ZSBSZWFjdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3

b3JkPkluZmFudDwva2V5d29yZD48a2V5d29yZD5JbmZhbnQsIE5ld2Jvcm48L2tleXdvcmQ+PGtl

eXdvcmQ+SW50ZXN0aW5hbCBNdWNvc2EvbWV0YWJvbGlzbS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+TGlwb3BvbHlzYWNjaGFyaWRlcy9iaW9zeW50aGVzaXMvKmltbXVub2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+TWFubmFucy9jaGVtaXN0cnkvaW1tdW5vbG9neTwva2V5d29yZD48a2V5

d29yZD5Nb2RlbHMsIEltbXVub2xvZ2ljYWw8L2tleXdvcmQ+PGtleXdvcmQ+U2Vyb2xvZ2ljIFRl

c3RzPC9rZXl3b3JkPjxrZXl3b3JkPlRlaWNob2ljIEFjaWRzL2Jpb3N5bnRoZXNpcy8qaW1tdW5v

bG9neTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA0PC95ZWFyPjxwdWItZGF0

ZXM+PGRhdGU+SmFuIDI0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQ3NC01NDdY

IChFbGVjdHJvbmljKSYjeEQ7MDE0MC02NzM2IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51

bT4xNDc1MTcxMDwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xNDc1MTcxMDwvdXJsPjwvcmVsYXRlZC11cmxz

PjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9TMDE0MC02NzM2KDAzKTE1

MzkzLTc8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZW5uaW5rLUtlcnN0ZW48L0F1dGhvcj48WWVhcj4yMDA1

PC9ZZWFyPjxSZWNOdW0+MTI1MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTE5LTEyMl08L0Rpc3Bs

YXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTI1MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNmd3Jl

eCI+MTI1MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGlj

bGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWVubmluay1L

ZXJzdGVuLCBNLiBBLjwvYXV0aG9yPjxhdXRob3I+UnVlZ2VicmluaywgRC48L2F1dGhvcj48YXV0

aG9yPktsb250LCBSLiBSLjwvYXV0aG9yPjxhdXRob3I+V2FycmlzLCBBLjwvYXV0aG9yPjxhdXRo

b3I+R2F2aW5pLCBGLjwvYXV0aG9yPjxhdXRob3I+T3AgZGVuIENhbXAsIEguIEouPC9hdXRob3I+

PGF1dGhvcj5WZXJ3ZWlqLCBQLiBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgTWVkaWNhbCBNaWNyb2Jpb2xvZ3ksIFJhZGJvdWQg

VW5pdmVyc2l0eSBOaWptZWdlbiBNZWRpY2FsIENlbnRlciwgUC5PLiBCb3ggOTEwMSwgNjUwMCBI

QiBOaWptZWdlbiwgVGhlIE5ldGhlcmxhbmRzLiBtLm1lbm5pbmtAbW1iLnVtY24ubmw8L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5CaWZpZG9iYWN0ZXJpYWwgbGlwb2dseWNhbiBhcyBhIG5l

dyBjYXVzZSBmb3IgZmFsc2UtcG9zaXRpdmUgcGxhdGVsaWEgQXNwZXJnaWxsdXMgZW56eW1lLWxp

bmtlZCBpbW11bm9zb3JiZW50IGFzc2F5IHJlYWN0aXZpdHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0

LXRpdGxlPkpvdXJuYWwgb2YgY2xpbmljYWwgbWljcm9iaW9sb2d5PC9hbHQtdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xv

Z3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIENsaW4gTWljcm9iaW9sPC9hYmJyLTE+PC9wZXJpb2Rp

Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE1pY3Jv

YmlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkogQ2xpbiBNaWNyb2Jpb2w8L2FiYnItMT48L2Fs

dC1wZXJpb2RpY2FsPjxwYWdlcz4zOTI1LTMxPC9wYWdlcz48dm9sdW1lPjQzPC92b2x1bWU+PG51

bWJlcj44PC9udW1iZXI+PGVkaXRpb24+MjAwNS8wOC8wNjwvZWRpdGlvbj48a2V5d29yZHM+PGtl

eXdvcmQ+QW50aWdlbnMsIEZ1bmdhbC8gYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJn

aWxsb3Npcy8gZGlhZ25vc2lzPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzLyBpbW11bm9s

b2d5PC9rZXl3b3JkPjxrZXl3b3JkPkJpZmlkb2JhY3Rlcml1bS8gaW1tdW5vbG9neTwva2V5d29y

ZD48a2V5d29yZD5Dcm9zcyBSZWFjdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+RW56eW1lLUxpbmtl

ZCBJbW11bm9zb3JiZW50IEFzc2F5PC9rZXl3b3JkPjxrZXl3b3JkPkZhbHNlIFBvc2l0aXZlIFJl

YWN0aW9uczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5mYW50

LCBOZXdib3JuPC9rZXl3b3JkPjxrZXl3b3JkPkxpcG9wb2x5c2FjY2hhcmlkZXMvIGltbXVub2xv

Z3k8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNTwveWVhcj48cHViLWRhdGVz

PjxkYXRlPkF1ZzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwOTUtMTEzNyAoUHJp

bnQpJiN4RDswMDk1LTExMzcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE2MDgxOTMy

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48Y3VzdG9tMj4xMjMzOTc5PC9jdXN0b20yPjxl

bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTI4L2pjbS40My44LjM5MjUtMzkzMS4yMDA1PC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVt

b3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPlN1bGFoaWFuPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48UmVj

TnVtPjEyNTI8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEyNTI8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJw

dzA1ZmZzZndyZXgiPjEyNTI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PlN1bGFoaWFuLCBBLjwvYXV0aG9yPjxhdXRob3I+VG91cmF0aWVyLCBTLjwvYXV0aG9yPjxhdXRo

b3I+UmliYXVkLCBQLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0

aXRsZT5GYWxzZSBwb3NpdGl2ZSB0ZXN0IGZvciBhc3BlcmdpbGx1cyBhbnRpZ2VuZW1pYSByZWxh

dGVkIHRvIGNvbmNvbWl0YW50IGFkbWluaXN0cmF0aW9uIG9mIHBpcGVyYWNpbGxpbiBhbmQgdGF6

b2JhY3RhbTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1l

ZGljaW5lPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5UaGUgTmV3IEVuZ2xhbmQgam91cm5h

bCBvZiBtZWRpY2luZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl

Pk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVu

Z2wgSiBNZWQ8L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjIzNjYtNzwvcGFnZXM+PHZvbHVt

ZT4zNDk8L3ZvbHVtZT48bnVtYmVyPjI0PC9udW1iZXI+PGVkaXRpb24+MjAwMy8xMi8xMjwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW50aWdlbnMsIEZ1bmdhbC8gYmxvb2Q8L2tleXdvcmQ+

PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJn

aWxsdXMvIGltbXVub2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Q3Jvc3MgUmVhY3Rpb25zPC9rZXl3

b3JkPjxrZXl3b3JkPkRydWcgVGhlcmFweSwgQ29tYmluYXRpb24vaW1tdW5vbG9neS8gdGhlcmFw

ZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkZhbHNlIFBvc2l0aXZlIFJlYWN0aW9uczwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8gYmxvb2QvaW1t

dW5vbG9neTwva2V5d29yZD48a2V5d29yZD5QZW5pY2lsbGFuaWMgQWNpZC8gYW5hbG9ncyAmYW1w

OyBkZXJpdmF0aXZlcy9pbW11bm9sb2d5LyB0aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdv

cmQ+UGlwZXJhY2lsbGluL2ltbXVub2xvZ3kvIHRoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5

d29yZD5iZXRhLUxhY3RhbWFzZXMvYW50YWdvbmlzdHMgJmFtcDsgaW5oaWJpdG9yczwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RGVj

IDExPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzMy00NDA2IChFbGVjdHJvbmlj

KSYjeEQ7MDAyOC00NzkzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xNDY2ODQ3Mjwv

YWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEw

NTYvbmVqbTIwMDMxMjExMzQ5MjQyNDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1k

YXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+

ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NZW5uaW5rLUtlcnN0

ZW48L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxSZWNOdW0+ODE0PC9SZWNOdW0+PHJlY29yZD48

cmVjLW51bWJlcj44MTQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQ1

NDM3MzcwMiI+ODE0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NZW5u

aW5rLUtlcnN0ZW4sIE0uIEEuPC9hdXRob3I+PGF1dGhvcj5Eb25uZWxseSwgSi4gUC48L2F1dGhv

cj48YXV0aG9yPlZlcndlaWosIFAuIEUuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBNZWRpY2FsIE1pY3JvYmlvbG9neSwgVW5pdmVy

c2l0eSBNZWRpY2FsIENlbnRlciBTdCBSYWRib3VkLCBOaWppbWVnZW4sIFRoZSBOZXRoZXJsYW5k

cy48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EZXRlY3Rpb24gb2YgY2lyY3VsYXRpbmcg

Z2FsYWN0b21hbm5hbiBmb3IgdGhlIGRpYWdub3NpcyBhbmQgbWFuYWdlbWVudCBvZiBpbnZhc2l2

ZSBhc3BlcmdpbGxvc2lzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkxhbmNldCBJbmZlY3QgRGlz

PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TGFuY2V0

IEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5MYW5jZXQgSW5mZWN0LiBE

aXMuPC9hYmJyLTE+PGFiYnItMj5MYW5jZXQgSW5mZWN0IERpczwvYWJici0yPjwvcGVyaW9kaWNh

bD48cGFnZXM+MzQ5LTU3PC9wYWdlcz48dm9sdW1lPjQ8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJl

cj48a2V5d29yZHM+PGtleXdvcmQ+QW50aWdlbnMsIEZ1bmdhbC9hbmFseXNpczwva2V5d29yZD48

a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2Jsb29kLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+

QXNwZXJnaWxsdXMvaW1tdW5vbG9neTwva2V5d29yZD48a2V5d29yZD5CaW9tYXJrZXJzL2Jsb29k

PC9rZXl3b3JkPjxrZXl3b3JkPkVuenltZS1MaW5rZWQgSW1tdW5vc29yYmVudCBBc3NheTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8qYmxvb2Q8L2tl

eXdvcmQ+PGtleXdvcmQ+UmVhZ2VudCBLaXRzLCBEaWFnbm9zdGljPC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMDQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdW48L2RhdGU+PC9w

dWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDczLTMwOTkgKFByaW50KSYjeEQ7MTQ3My0zMDk5IChM

aW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xNTE3MjM0MzwvYWNjZXNzaW9uLW51bT48dXJs

cz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8x

NTE3MjM0MzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+MTAuMTAxNi9TMTQ3My0zMDk5KDA0KTAxMDQ1LVg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt

PjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPk1lbm5pbmstS2Vyc3RlbjwvQXV0aG9yPjxZ

ZWFyPjIwMDQ8L1llYXI+PFJlY051bT44MTU8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjgx

NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjI1d3M5OXJm

bncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDU0MzczNzYyIj44MTU8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1lbm5pbmstS2Vyc3Rlbiwg

TS4gQS48L2F1dGhvcj48YXV0aG9yPktsb250LCBSLiBSLjwvYXV0aG9yPjxhdXRob3I+V2Fycmlz

LCBBLjwvYXV0aG9yPjxhdXRob3I+T3AgZGVuIENhbXAsIEguIEouPC9hdXRob3I+PGF1dGhvcj5W

ZXJ3ZWlqLCBQLiBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPkRlcGFydG1lbnQgb2YgTWVkaWNhbCBNaWNyb2Jpb2xvZ3ksIFVuaXZlcnNpdHkgTWVkaWNh

bCBDZW50cmUgTmlqbWVnZW4sIE5ldGhlcmxhbmQuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0

bGU+QmlmaWRvYmFjdGVyaXVtIGxpcG90ZWljaG9pYyBhY2lkIGFuZCBmYWxzZSBFTElTQSByZWFj

dGl2aXR5IGluIGFzcGVyZ2lsbHVzIGFudGlnZW4gZGV0ZWN0aW9uPC90aXRsZT48c2Vjb25kYXJ5

LXRpdGxlPkxhbmNldDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxs

LXRpdGxlPkxhbmNldDwvZnVsbC10aXRsZT48YWJici0xPkxhbmNldDwvYWJici0xPjxhYmJyLTI+

TGFuY2V0PC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz4zMjUtNzwvcGFnZXM+PHZvbHVtZT4z

NjM8L3ZvbHVtZT48bnVtYmVyPjk0MDU8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QW50aWJv

ZGllcywgTW9ub2Nsb25hbC9pbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkFudGlnZW5zLCBG

dW5nYWwvKmltbXVub2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy9kaWFnbm9z

aXMvaW1tdW5vbG9neTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy9ncm93dGggJmFtcDsg

ZGV2ZWxvcG1lbnQvKmltbXVub2xvZ3kvbWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5CaWZp

ZG9iYWN0ZXJpdW0vZ3Jvd3RoICZhbXA7IGRldmVsb3BtZW50LyptZXRhYm9saXNtPC9rZXl3b3Jk

PjxrZXl3b3JkPkNyb3NzIFJlYWN0aW9ucy9pbW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkVu

enltZS1MaW5rZWQgSW1tdW5vc29yYmVudCBBc3NheS8qc3RhdGlzdGljcyAmYW1wOyBudW1lcmlj

YWwgZGF0YTwva2V5d29yZD48a2V5d29yZD5FcGl0b3Blcy9pbW11bm9sb2d5PC9rZXl3b3JkPjxr

ZXl3b3JkPkZhbHNlIE5lZ2F0aXZlIFJlYWN0aW9uczwva2V5d29yZD48a2V5d29yZD5GYWxzZSBQ

b3NpdGl2ZSBSZWFjdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3

b3JkPkluZmFudDwva2V5d29yZD48a2V5d29yZD5JbmZhbnQsIE5ld2Jvcm48L2tleXdvcmQ+PGtl

eXdvcmQ+SW50ZXN0aW5hbCBNdWNvc2EvbWV0YWJvbGlzbS9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+

PGtleXdvcmQ+TGlwb3BvbHlzYWNjaGFyaWRlcy9iaW9zeW50aGVzaXMvKmltbXVub2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+TWFubmFucy9jaGVtaXN0cnkvaW1tdW5vbG9neTwva2V5d29yZD48a2V5

d29yZD5Nb2RlbHMsIEltbXVub2xvZ2ljYWw8L2tleXdvcmQ+PGtleXdvcmQ+U2Vyb2xvZ2ljIFRl

c3RzPC9rZXl3b3JkPjxrZXl3b3JkPlRlaWNob2ljIEFjaWRzL2Jpb3N5bnRoZXNpcy8qaW1tdW5v

bG9neTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA0PC95ZWFyPjxwdWItZGF0

ZXM+PGRhdGU+SmFuIDI0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQ3NC01NDdY

IChFbGVjdHJvbmljKSYjeEQ7MDE0MC02NzM2IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51

bT4xNDc1MTcxMDwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xNDc1MTcxMDwvdXJsPjwvcmVsYXRlZC11cmxz

PjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9TMDE0MC02NzM2KDAzKTE1

MzkzLTc8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [119-122]. Despite these limitations, this assay is a useful adjunctive test to establish an early diagnosis, particularly when used in serial screening of patients at high risk of infection who are not receiving anti-mould prophylaxis. The optimal rationale for diagnosis in neutropenic patients may be a combined approach guided by clinical, radiographic, and bi-weekly screening of GM in serum PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TY2h3YXJ6aW5nZXI8L0F1dGhvcj48WWVhcj4yMDEzPC9Z

ZWFyPjxSZWNOdW0+MTI1MzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTIzXTwvRGlzcGxheVRleHQ+

PHJlY29yZD48cmVjLW51bWJlcj4xMjUzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjUz

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5TY2h3YXJ6aW5nZXIsIE0u

PC9hdXRob3I+PGF1dGhvcj5TYWdhb24tVGV5c3NpZXIsIEwuPC9hdXRob3I+PGF1dGhvcj5DYWJh

cmV0LCBPLjwvYXV0aG9yPjxhdXRob3I+QnJldGFnbmUsIFMuPC9hdXRob3I+PGF1dGhvcj5Db3Jk

b25uaWVyLCBDLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNz

PkVxdWlwZSBBVElQL0FWRU5JUiwgSU5TRVJNLCBVTVIgNzM4LCBQYXJpcywgRnJhbmNlLiBtaWNo

YWVsLnNjaHdhcnppbmdlckBpbnNlcm0uZnI8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Q

ZXJmb3JtYW5jZSBvZiBzZXJ1bSBiaW9tYXJrZXJzIGZvciB0aGUgZWFybHkgZGV0ZWN0aW9uIG9m

IGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgaW4gZmVicmlsZSwgbmV1dHJvcGVuaWMgcGF0aWVudHM6

IGEgbXVsdGktc3RhdGUgbW9kZWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+UExvUyBPbmU8L3Nl

Y29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlBsb1Mgb25lPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+UExvUyBPbmU8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxh

bHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QTG9TIE9uZTwvZnVsbC10aXRsZT48L2FsdC1wZXJp

b2RpY2FsPjxwYWdlcz5lNjU3NzY8L3BhZ2VzPjx2b2x1bWU+ODwvdm9sdW1lPjxudW1iZXI+Njwv

bnVtYmVyPjxlZGl0aW9uPjIwMTMvMDYvMjc8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFk

dWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWZ1bmdhbCBB

Z2VudHMvYWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdlPC9rZXl3b3JkPjxrZXl3b3JkPkFudGln

ZW5zLCBGdW5nYWwvYmxvb2Q8L2tleXdvcmQ+PGtleXdvcmQ+QW50aW5lb3BsYXN0aWMgQWdlbnRz

L2FkdmVyc2UgZWZmZWN0cy90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QmlvbG9n

aWNhbCBNYXJrZXJzL2Jsb29kPC9rZXl3b3JkPjxrZXl3b3JkPkNoZW1vdGhlcmFweS1JbmR1Y2Vk

IEZlYnJpbGUgTmV1dHJvcGVuaWEvIGJsb29kL2ltbXVub2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+

RE5BLCBGdW5nYWwvYmxvb2QvZ2VuZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+RWFybHkgRGlhZ25v

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5GdW5nYWwgUG9s

eXNhY2NoYXJpZGVzLyBibG9vZDwva2V5d29yZD48a2V5d29yZD5HZW5lcywgRnVuZ2FsPC9rZXl3

b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbnZhc2l2ZSBQdWxtb25hcnkg

QXNwZXJnaWxsb3Npcy9ibG9vZC8gZGlhZ25vc2lzL2RydWcgdGhlcmFweTwva2V5d29yZD48a2V5

d29yZD5MZXVrZW1pYSwgTXllbG9pZCwgQWN1dGUvYmxvb2QvZHJ1ZyB0aGVyYXB5PC9rZXl3b3Jk

PjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8gYmxvb2Q8L2tleXdvcmQ+

PGtleXdvcmQ+TWFya292IENoYWluczwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5

d29yZD48a2V5d29yZD5Nb2RlbHMsIEJpb2xvZ2ljYWw8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3Bl

Y3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SYW5kb21pemVkIENvbnRyb2xsZWQgVHJp

YWxzIGFzIFRvcGljPC9rZXl3b3JkPjxrZXl3b3JkPlJlYWwtVGltZSBQb2x5bWVyYXNlIENoYWlu

IFJlYWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPmJldGEtR2x1Y2Fucy9ibG9vZDwva2V5d29yZD48

L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTkzMi02MjAz

IChFbGVjdHJvbmljKSYjeEQ7MTkzMi02MjAzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51

bT4yMzc5OTA0ODwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGN1c3RvbTI+MzY4MzA0Nzwv

Y3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTM3MS9qb3VybmFsLnBvbmUuMDA2

NTc3NjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5O

TE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3Jl

Y29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TY2h3YXJ6aW5nZXI8L0F1dGhvcj48WWVhcj4yMDEzPC9Z

ZWFyPjxSZWNOdW0+MTI1MzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTIzXTwvRGlzcGxheVRleHQ+

PHJlY29yZD48cmVjLW51bWJlcj4xMjUzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMjUz

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5TY2h3YXJ6aW5nZXIsIE0u

PC9hdXRob3I+PGF1dGhvcj5TYWdhb24tVGV5c3NpZXIsIEwuPC9hdXRob3I+PGF1dGhvcj5DYWJh

cmV0LCBPLjwvYXV0aG9yPjxhdXRob3I+QnJldGFnbmUsIFMuPC9hdXRob3I+PGF1dGhvcj5Db3Jk

b25uaWVyLCBDLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNz

PkVxdWlwZSBBVElQL0FWRU5JUiwgSU5TRVJNLCBVTVIgNzM4LCBQYXJpcywgRnJhbmNlLiBtaWNo

YWVsLnNjaHdhcnppbmdlckBpbnNlcm0uZnI8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Q

ZXJmb3JtYW5jZSBvZiBzZXJ1bSBiaW9tYXJrZXJzIGZvciB0aGUgZWFybHkgZGV0ZWN0aW9uIG9m

IGludmFzaXZlIGFzcGVyZ2lsbG9zaXMgaW4gZmVicmlsZSwgbmV1dHJvcGVuaWMgcGF0aWVudHM6

IGEgbXVsdGktc3RhdGUgbW9kZWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+UExvUyBPbmU8L3Nl

Y29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlBsb1Mgb25lPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+UExvUyBPbmU8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxh

bHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QTG9TIE9uZTwvZnVsbC10aXRsZT48L2FsdC1wZXJp

b2RpY2FsPjxwYWdlcz5lNjU3NzY8L3BhZ2VzPjx2b2x1bWU+ODwvdm9sdW1lPjxudW1iZXI+Njwv

bnVtYmVyPjxlZGl0aW9uPjIwMTMvMDYvMjc8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFk

dWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW50aWZ1bmdhbCBB

Z2VudHMvYWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdlPC9rZXl3b3JkPjxrZXl3b3JkPkFudGln

ZW5zLCBGdW5nYWwvYmxvb2Q8L2tleXdvcmQ+PGtleXdvcmQ+QW50aW5lb3BsYXN0aWMgQWdlbnRz

L2FkdmVyc2UgZWZmZWN0cy90aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+QmlvbG9n

aWNhbCBNYXJrZXJzL2Jsb29kPC9rZXl3b3JkPjxrZXl3b3JkPkNoZW1vdGhlcmFweS1JbmR1Y2Vk

IEZlYnJpbGUgTmV1dHJvcGVuaWEvIGJsb29kL2ltbXVub2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+

RE5BLCBGdW5nYWwvYmxvb2QvZ2VuZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+RWFybHkgRGlhZ25v

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5GdW5nYWwgUG9s

eXNhY2NoYXJpZGVzLyBibG9vZDwva2V5d29yZD48a2V5d29yZD5HZW5lcywgRnVuZ2FsPC9rZXl3

b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbnZhc2l2ZSBQdWxtb25hcnkg

QXNwZXJnaWxsb3Npcy9ibG9vZC8gZGlhZ25vc2lzL2RydWcgdGhlcmFweTwva2V5d29yZD48a2V5

d29yZD5MZXVrZW1pYSwgTXllbG9pZCwgQWN1dGUvYmxvb2QvZHJ1ZyB0aGVyYXB5PC9rZXl3b3Jk

PjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8gYmxvb2Q8L2tleXdvcmQ+

PGtleXdvcmQ+TWFya292IENoYWluczwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5

d29yZD48a2V5d29yZD5Nb2RlbHMsIEJpb2xvZ2ljYWw8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3Bl

Y3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SYW5kb21pemVkIENvbnRyb2xsZWQgVHJp

YWxzIGFzIFRvcGljPC9rZXl3b3JkPjxrZXl3b3JkPlJlYWwtVGltZSBQb2x5bWVyYXNlIENoYWlu

IFJlYWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPmJldGEtR2x1Y2Fucy9ibG9vZDwva2V5d29yZD48

L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTkzMi02MjAz

IChFbGVjdHJvbmljKSYjeEQ7MTkzMi02MjAzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51

bT4yMzc5OTA0ODwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGN1c3RvbTI+MzY4MzA0Nzwv

Y3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTM3MS9qb3VybmFsLnBvbmUuMDA2

NTc3NjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5O

TE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3Jl

Y29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [123], possibly combined with other biomarkers. In patients receiving mould active antifungal prophylaxis, the use of serum GM as a screening tool results in a very poor predictive value with most positive tests being false positive in this setting ADDIN EN.CITE <EndNote><Cite><Author>Duarte</Author><Year>2014</Year><RecNum>173</RecNum><DisplayText>[124]</DisplayText><record><rec-number>173</rec-number><foreign-keys><key app="EN" db-id="25ws99rfnw2zfmert5rxzapsprpa5wr2efdr" timestamp="1412206142">173</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Duarte, R. F.</author><author>Sanchez-Ortega, I.</author><author>Cuesta, I.</author><author>Arnan, M.</author><author>Patino, B.</author><author>Fernandez de Sevilla, A.</author><author>Gudiol, C.</author><author>Ayats, J.</author><author>Cuenca-Estrella, M.</author></authors></contributors><auth-address>Department of Hematology, Catalan Institute of Oncology - Hospital Duran i Reynals, Barcelona, Spain rduarte@.&#xD;Department of Hematology, Catalan Institute of Oncology - Hospital Duran i Reynals, Barcelona, Spain.&#xD;Centro Nacional de Microbiologia - Instituto de Salud Carlos III, Madrid, Spain.&#xD;Department of Microbiology, Hospital Universitario de Bellvitge, Barcelona, Spain.</auth-address><titles><title>Serum galactomannan-based early detection of invasive aspergillosis in hematology patients receiving effective anti-mold prophylaxis</title><secondary-title>Clin Infect Dis</secondary-title><alt-title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</alt-title></titles><periodical><full-title>Clinical Infectious Diseases</full-title><abbr-1>Clin. Infect. Dis.</abbr-1><abbr-2>Clin Infect Dis</abbr-2></periodical><dates><year>2014</year><pub-dates><date>Aug 27</date></pub-dates></dates><isbn>1537-6591 (Electronic)&#xD;1058-4838 (Linking)</isbn><accession-num>25165088</accession-num><urls><related-urls><url>;[124]. The detection of GM in BAL fluid has been shown to have a sensitivity that exceeds 70% in most studies and provides additional sensitivity compared to cultures even in the setting of mould-active antifungal therapy as discussed below PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IdXNhaW48L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+NDY0PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMjUtMTI4XTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj40NjQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFt

cD0iMTQyNDkxMTgyNyI+NDY0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5IdXNhaW4sIFMuPC9hdXRob3I+PGF1dGhvcj5DbGFuY3ksIEMuIEouPC9hdXRob3I+PGF1dGhv

cj5OZ3V5ZW4sIE0uIEguPC9hdXRob3I+PGF1dGhvcj5Td2FydHplbnRydWJlciwgUy48L2F1dGhv

cj48YXV0aG9yPkxlYXRoZXIsIEguPC9hdXRob3I+PGF1dGhvcj5MZU1vbnRlLCBBLiBNLjwvYXV0

aG9yPjxhdXRob3I+RHVya2luLCBNLiBNLjwvYXV0aG9yPjxhdXRob3I+S25veCwgSy4gUy48L2F1

dGhvcj48YXV0aG9yPkhhZ2UsIEMuIEEuPC9hdXRob3I+PGF1dGhvcj5CZW50c2VuLCBDLjwvYXV0

aG9yPjxhdXRob3I+U2luZ2gsIE4uPC9hdXRob3I+PGF1dGhvcj5XaW5nYXJkLCBKLiBSLjwvYXV0

aG9yPjxhdXRob3I+V2hlYXQsIEwuIEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+VW5pdmVyc2l0eSBvZiBQaXR0c2J1cmdoLCBQaXR0c2J1cmdoLCBQQSwg

VVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlBlcmZvcm1hbmNlIGNoYXJhY3Rlcmlz

dGljcyBvZiB0aGUgcGxhdGVsaWEgQXNwZXJnaWxsdXMgZW56eW1lIGltbXVub2Fzc2F5IGZvciBk

ZXRlY3Rpb24gb2YgQXNwZXJnaWxsdXMgZ2FsYWN0b21hbm5hbiBhbnRpZ2VuIGluIGJyb25jaG9h

bHZlb2xhciBsYXZhZ2UgZmx1aWQ8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2xpbiBWYWNjaW5l

IEltbXVub2w8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGFuZCB2YWNjaW5l

IGltbXVub2xvZ3kgOiBDVkk8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5DbGluaWNhbCBhbmQgVmFjY2luZSBJbW11bm9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+

Q2xpbi4gVmFjY2luZSBJbW11bm9sLjwvYWJici0xPjxhYmJyLTI+Q2xpbiBWYWNjaW5lIEltbXVu

b2w8L2FiYnItMj48YWJici0zPkNsaW5pY2FsICZhbXA7IFZhY2NpbmUgSW1tdW5vbG9neTwvYWJi

ci0zPjwvcGVyaW9kaWNhbD48cGFnZXM+MTc2MC0zPC9wYWdlcz48dm9sdW1lPjE1PC92b2x1bWU+

PG51bWJlcj4xMjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbnRpZ2VucywgRnVuZ2FsLyph

bmFseXNpczwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzLypkaWFnbm9zaXM8L2tleXdv

cmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvaW1tdW5vbG9neS8qaXNvbGF0aW9uICZhbXA7IHB1cmlm

aWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkLypp

bW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW1t

dW5vZW56eW1lIFRlY2huaXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8qYW5hbHlzaXM8

L2tleXdvcmQ+PGtleXdvcmQ+UmVwcm9kdWNpYmlsaXR5IG9mIFJlc3VsdHM8L2tleXdvcmQ+PGtl

eXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMDg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWM8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xNTU2LTY3OVggKEVsZWN0cm9uaWMpJiN4RDsxNTU2LTY3OVggKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE4ODQ1ODMwPC9hY2Nlc3Npb24tbnVtPjx1cmxz

PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzE4

ODQ1ODMwPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPjI1OTMxNzQ8L2N1c3Rv

bTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMjgvQ1ZJLjAwMjI2LTA4PC9lbGVjdHJv

bmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NdXNoZXI8L0F1

dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxSZWNOdW0+NDY1PC9SZWNOdW0+PHJlY29yZD48cmVjLW51

bWJlcj40NjU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIy

NXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQyNDkxMjE4

OSI+NDY1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNs

ZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NdXNoZXIsIEIu

PC9hdXRob3I+PGF1dGhvcj5GcmVkcmlja3MsIEQuPC9hdXRob3I+PGF1dGhvcj5MZWlzZW5yaW5n

LCBXLjwvYXV0aG9yPjxhdXRob3I+QmFsYWplZSwgUy4gQS48L2F1dGhvcj48YXV0aG9yPlNtaXRo

LCBDLjwvYXV0aG9yPjxhdXRob3I+TWFyciwgSy4gQS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250

cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Vbml2ZXJzaXR5IG9mIFdhc2hpbmd0b24sIFNlYXR0bGUs

IFdBLCBVU0EuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QXNwZXJnaWxsdXMgZ2FsYWN0

b21hbm5hbiBlbnp5bWUgaW1tdW5vYXNzYXkgYW5kIHF1YW50aXRhdGl2ZSBQQ1IgZm9yIGRpYWdu

b3NpcyBvZiBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIHdpdGggYnJvbmNob2FsdmVvbGFyIGxhdmFn

ZSBmbHVpZDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIENsaW4gTWljcm9iaW9sPC9zZWNvbmRh

cnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFsIG9mIGNsaW5pY2FsIG1pY3JvYmlvbG9neTwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmlj

YWwgTWljcm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQ2xpbi4gTWljcm9iaW9sLjwv

YWJici0xPjxhYmJyLTI+SiBDbGluIE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0

LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3k8

L2Z1bGwtdGl0bGU+PGFiYnItMT5KLiBDbGluLiBNaWNyb2Jpb2wuPC9hYmJyLTE+PGFiYnItMj5K

IENsaW4gTWljcm9iaW9sPC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NTUxNy0yMjwv

cGFnZXM+PHZvbHVtZT40Mjwvdm9sdW1lPjxudW1iZXI+MTI8L251bWJlcj48a2V5d29yZHM+PGtl

eXdvcmQ+QXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzL21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5

d29yZD5Bc3BlcmdpbGx1cy9nZW5ldGljcy8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwv

a2V5d29yZD48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkLyptaWNyb2Jpb2xv

Z3k8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvcG9pZXRpYyBTdGVtIENlbGwgVHJhbnNwbGFudGF0

aW9uL2FkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+SW1tdW5vZW56eW1lIFRlY2huaXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBEaXNl

YXNlcywgRnVuZ2FsLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8qYW5hbHlz

aXM8L2tleXdvcmQ+PGtleXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBSZWFjdGlvbi8qbWV0aG9kczwv

a2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PC9r

ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNDwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRlYzwvZGF0

ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwOTUtMTEzNyAoUHJpbnQpJiN4RDswMDk1LTEx

MzcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE1NTgzMjc1PC9hY2Nlc3Npb24tbnVt

Pjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVi

bWVkLzE1NTgzMjc1PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPjUzNTIzODwv

Y3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTEyOC9KQ00uNDIuMTIuNTUxNy01

NTIyLjIwMDQ8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48

QXV0aG9yPk1hZXJ0ZW5zPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48UmVjTnVtPjQ2NjwvUmVj

TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NDY2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0

aW1lc3RhbXA9IjE0MjQ5MTIzMjAiPjQ2Njwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBu

YW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3Jz

PjxhdXRob3I+TWFlcnRlbnMsIEouPC9hdXRob3I+PGF1dGhvcj5NYWVydGVucywgVi48L2F1dGhv

cj48YXV0aG9yPlRoZXVuaXNzZW4sIEsuPC9hdXRob3I+PGF1dGhvcj5NZWVyc3NlbWFuLCBXLjwv

YXV0aG9yPjxhdXRob3I+TWVlcnNzZW1hbiwgUC48L2F1dGhvcj48YXV0aG9yPk1lZXJzLCBTLjwv

YXV0aG9yPjxhdXRob3I+VmVyYmVrZW4sIEUuPC9hdXRob3I+PGF1dGhvcj5WZXJob2VmLCBHLjwv

YXV0aG9yPjxhdXRob3I+VmFuIEVsZGVyZSwgSi48L2F1dGhvcj48YXV0aG9yPkxhZ3JvdSwgSy48

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50

IG9mIEhlbWF0b2xvZ3ksIE1lZGljYWwgSW50ZW5zaXZlIENhcmUgVW5pdCwgVW5pdmVyc2l0eSBI

b3NwaXRhbCBHYXN0aHVpc2JlcmcsIExldXZlbiwgQmVsZ2l1bTwvYXV0aC1hZGRyZXNzPjx0aXRs

ZXM+PHRpdGxlPkJyb25jaG9hbHZlb2xhciBsYXZhZ2UgZmx1aWQgZ2FsYWN0b21hbm5hbiBmb3Ig

dGhlIGRpYWdub3NpcyBvZiBpbnZhc2l2ZSBwdWxtb25hcnkgYXNwZXJnaWxsb3NpcyBpbiBwYXRp

ZW50cyB3aXRoIGhlbWF0b2xvZ2ljIGRpc2Vhc2VzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNs

aW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwgaW5mZWN0

aW91cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZlY3Rpb3Vz

IERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+

PGFiYnItMT5DbGluLiBJbmZlY3QuIERpcy48L2FiYnItMT48YWJici0yPkNsaW4gSW5mZWN0IERp

czwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MTY4OC05MzwvcGFnZXM+PHZvbHVtZT40OTwv

dm9sdW1lPjxudW1iZXI+MTE8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QnJvbmNob2FsdmVv

bGFyIExhdmFnZSBGbHVpZC8qY2hlbWlzdHJ5PC9rZXl3b3JkPjxrZXl3b3JkPkNhc2UtQ29udHJv

bCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkhlbWF0b2xvZ2ljIERpc2Vhc2VzLypjb21wbGlj

YXRpb25zLyptaWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxr

ZXl3b3JkPkludmFzaXZlIFB1bG1vbmFyeSBBc3BlcmdpbGxvc2lzLypkaWFnbm9zaXM8L2tleXdv

cmQ+PGtleXdvcmQ+TWFubmFucy8qYW5hbHlzaXMvY2hlbWlzdHJ5PC9rZXl3b3JkPjxrZXl3b3Jk

Pk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5

d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRlYyAxPC9kYXRl

PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1

OC00ODM4IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xOTg4NjgwMTwvYWNjZXNzaW9u

LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8xOTg4NjgwMTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+MTAuMTA4Ni82NDc5MzU8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVj

b3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkQmYXBvcztIYWVzZTwvQXV0aG9yPjxZZWFyPjIwMTI8

L1llYXI+PFJlY051bT40Njc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjQ2NzwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0

NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDI0OTEyNDUwIj40Njc8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkQmYXBvcztIYWVzZSwgSi48L2F1dGhvcj48

YXV0aG9yPlRoZXVuaXNzZW4sIEsuPC9hdXRob3I+PGF1dGhvcj5WZXJtZXVsZW4sIEUuPC9hdXRo

b3I+PGF1dGhvcj5TY2hvZW1hbnMsIEguPC9hdXRob3I+PGF1dGhvcj5EZSBWbGllZ2VyLCBHLjwv

YXV0aG9yPjxhdXRob3I+TGFtbWVydGlqbiwgTC48L2F1dGhvcj48YXV0aG9yPk1lZXJzc2VtYW4s

IFAuPC9hdXRob3I+PGF1dGhvcj5NZWVyc3NlbWFuLCBXLjwvYXV0aG9yPjxhdXRob3I+TGFncm91

LCBLLjwvYXV0aG9yPjxhdXRob3I+TWFlcnRlbnMsIEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29u

dHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBIZW1hdG9sb2d5LCBBY3V0ZSBM

ZXVrZW1pYSBhbmQgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbiBVbml0LCBVbml2ZXJzaXRhaXJl

IFppZWtlbmh1aXplbiBMZXV2ZW4sIENhbXB1cyBHYXN0aHVpc2JlcmcsIENhdGhvbGljIFVuaXZl

cnNpdHkgb2YgTGV1dmVuLCBMZXV2ZW4sIEJlbGdpdW0uPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48

dGl0bGU+RGV0ZWN0aW9uIG9mIGdhbGFjdG9tYW5uYW4gaW4gYnJvbmNob2FsdmVvbGFyIGxhdmFn

ZSBmbHVpZCBzYW1wbGVzIG9mIHBhdGllbnRzIGF0IHJpc2sgZm9yIGludmFzaXZlIHB1bG1vbmFy

eSBhc3BlcmdpbGxvc2lzOiBhbmFseXRpY2FsIGFuZCBjbGluaWNhbCB2YWxpZGl0eTwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5KIENsaW4gTWljcm9iaW9sPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10

aXRsZT5Kb3VybmFsIG9mIGNsaW5pY2FsIG1pY3JvYmlvbG9neTwvYWx0LXRpdGxlPjwvdGl0bGVz

PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgTWljcm9iaW9sb2d5

PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQ2xpbi4gTWljcm9iaW9sLjwvYWJici0xPjxhYmJyLTI+

SiBDbGluIE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3k8L2Z1bGwtdGl0bGU+PGFi

YnItMT5KLiBDbGluLiBNaWNyb2Jpb2wuPC9hYmJyLTE+PGFiYnItMj5KIENsaW4gTWljcm9iaW9s

PC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTI1OC02MzwvcGFnZXM+PHZvbHVtZT41

MDwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50

PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+

PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+PGtleXdvcmQ+QnJvbmNob2FsdmVv

bGFyIExhdmFnZSBGbHVpZC8qY2hlbWlzdHJ5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkltbXVub2NvbXByb21pc2Vk

IEhvc3Q8L2tleXdvcmQ+PGtleXdvcmQ+SW52YXNpdmUgUHVsbW9uYXJ5IEFzcGVyZ2lsbG9zaXMv

KmRpYWdub3Npcy9pbW11bm9sb2d5L3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9r

ZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvKmNoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5NaWRk

bGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5ST0MgQ3VydmU8L2tleXdvcmQ+PGtleXdvcmQ+UmV0

cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPllvdW5nIEFkdWx0PC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHI8

L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDk4LTY2MFggKEVsZWN0cm9uaWMpJiN4

RDswMDk1LTExMzcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyMzAxMDI1PC9hY2Nl

c3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5p

aC5nb3YvcHVibWVkLzIyMzAxMDI1PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20y

PjMzMTg1NjM8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMjgvSkNNLjA2

NDIzLTExPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3Rl

Pn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IdXNhaW48L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+NDY0PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMjUtMTI4XTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj40NjQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSIyNXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFt

cD0iMTQyNDkxMTgyNyI+NDY0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5IdXNhaW4sIFMuPC9hdXRob3I+PGF1dGhvcj5DbGFuY3ksIEMuIEouPC9hdXRob3I+PGF1dGhv

cj5OZ3V5ZW4sIE0uIEguPC9hdXRob3I+PGF1dGhvcj5Td2FydHplbnRydWJlciwgUy48L2F1dGhv

cj48YXV0aG9yPkxlYXRoZXIsIEguPC9hdXRob3I+PGF1dGhvcj5MZU1vbnRlLCBBLiBNLjwvYXV0

aG9yPjxhdXRob3I+RHVya2luLCBNLiBNLjwvYXV0aG9yPjxhdXRob3I+S25veCwgSy4gUy48L2F1

dGhvcj48YXV0aG9yPkhhZ2UsIEMuIEEuPC9hdXRob3I+PGF1dGhvcj5CZW50c2VuLCBDLjwvYXV0

aG9yPjxhdXRob3I+U2luZ2gsIE4uPC9hdXRob3I+PGF1dGhvcj5XaW5nYXJkLCBKLiBSLjwvYXV0

aG9yPjxhdXRob3I+V2hlYXQsIEwuIEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+VW5pdmVyc2l0eSBvZiBQaXR0c2J1cmdoLCBQaXR0c2J1cmdoLCBQQSwg

VVNBLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlBlcmZvcm1hbmNlIGNoYXJhY3Rlcmlz

dGljcyBvZiB0aGUgcGxhdGVsaWEgQXNwZXJnaWxsdXMgZW56eW1lIGltbXVub2Fzc2F5IGZvciBk

ZXRlY3Rpb24gb2YgQXNwZXJnaWxsdXMgZ2FsYWN0b21hbm5hbiBhbnRpZ2VuIGluIGJyb25jaG9h

bHZlb2xhciBsYXZhZ2UgZmx1aWQ8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2xpbiBWYWNjaW5l

IEltbXVub2w8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGFuZCB2YWNjaW5l

IGltbXVub2xvZ3kgOiBDVkk8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5DbGluaWNhbCBhbmQgVmFjY2luZSBJbW11bm9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+

Q2xpbi4gVmFjY2luZSBJbW11bm9sLjwvYWJici0xPjxhYmJyLTI+Q2xpbiBWYWNjaW5lIEltbXVu

b2w8L2FiYnItMj48YWJici0zPkNsaW5pY2FsICZhbXA7IFZhY2NpbmUgSW1tdW5vbG9neTwvYWJi

ci0zPjwvcGVyaW9kaWNhbD48cGFnZXM+MTc2MC0zPC9wYWdlcz48dm9sdW1lPjE1PC92b2x1bWU+

PG51bWJlcj4xMjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BbnRpZ2VucywgRnVuZ2FsLyph

bmFseXNpczwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzLypkaWFnbm9zaXM8L2tleXdv

cmQ+PGtleXdvcmQ+QXNwZXJnaWxsdXMvaW1tdW5vbG9neS8qaXNvbGF0aW9uICZhbXA7IHB1cmlm

aWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkLypp

bW11bm9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW1t

dW5vZW56eW1lIFRlY2huaXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8qYW5hbHlzaXM8

L2tleXdvcmQ+PGtleXdvcmQ+UmVwcm9kdWNpYmlsaXR5IG9mIFJlc3VsdHM8L2tleXdvcmQ+PGtl

eXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMDg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWM8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xNTU2LTY3OVggKEVsZWN0cm9uaWMpJiN4RDsxNTU2LTY3OVggKExp

bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE4ODQ1ODMwPC9hY2Nlc3Npb24tbnVtPjx1cmxz

PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzE4

ODQ1ODMwPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPjI1OTMxNzQ8L2N1c3Rv

bTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMjgvQ1ZJLjAwMjI2LTA4PC9lbGVjdHJv

bmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NdXNoZXI8L0F1

dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxSZWNOdW0+NDY1PC9SZWNOdW0+PHJlY29yZD48cmVjLW51

bWJlcj40NjU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIy

NXdzOTlyZm53MnpmbWVydDVyeHphcHNwcnBhNXdyMmVmZHIiIHRpbWVzdGFtcD0iMTQyNDkxMjE4

OSI+NDY1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNs

ZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NdXNoZXIsIEIu

PC9hdXRob3I+PGF1dGhvcj5GcmVkcmlja3MsIEQuPC9hdXRob3I+PGF1dGhvcj5MZWlzZW5yaW5n

LCBXLjwvYXV0aG9yPjxhdXRob3I+QmFsYWplZSwgUy4gQS48L2F1dGhvcj48YXV0aG9yPlNtaXRo

LCBDLjwvYXV0aG9yPjxhdXRob3I+TWFyciwgSy4gQS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250

cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Vbml2ZXJzaXR5IG9mIFdhc2hpbmd0b24sIFNlYXR0bGUs

IFdBLCBVU0EuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QXNwZXJnaWxsdXMgZ2FsYWN0

b21hbm5hbiBlbnp5bWUgaW1tdW5vYXNzYXkgYW5kIHF1YW50aXRhdGl2ZSBQQ1IgZm9yIGRpYWdu

b3NpcyBvZiBpbnZhc2l2ZSBhc3BlcmdpbGxvc2lzIHdpdGggYnJvbmNob2FsdmVvbGFyIGxhdmFn

ZSBmbHVpZDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIENsaW4gTWljcm9iaW9sPC9zZWNvbmRh

cnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFsIG9mIGNsaW5pY2FsIG1pY3JvYmlvbG9neTwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmlj

YWwgTWljcm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQ2xpbi4gTWljcm9iaW9sLjwv

YWJici0xPjxhYmJyLTI+SiBDbGluIE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0

LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3k8

L2Z1bGwtdGl0bGU+PGFiYnItMT5KLiBDbGluLiBNaWNyb2Jpb2wuPC9hYmJyLTE+PGFiYnItMj5K

IENsaW4gTWljcm9iaW9sPC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NTUxNy0yMjwv

cGFnZXM+PHZvbHVtZT40Mjwvdm9sdW1lPjxudW1iZXI+MTI8L251bWJlcj48a2V5d29yZHM+PGtl

eXdvcmQ+QXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzL21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5

d29yZD5Bc3BlcmdpbGx1cy9nZW5ldGljcy8qaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwv

a2V5d29yZD48a2V5d29yZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkLyptaWNyb2Jpb2xv

Z3k8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvcG9pZXRpYyBTdGVtIENlbGwgVHJhbnNwbGFudGF0

aW9uL2FkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+SW1tdW5vZW56eW1lIFRlY2huaXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBEaXNl

YXNlcywgRnVuZ2FsLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8qYW5hbHlz

aXM8L2tleXdvcmQ+PGtleXdvcmQ+UG9seW1lcmFzZSBDaGFpbiBSZWFjdGlvbi8qbWV0aG9kczwv

a2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PC9r

ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNDwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRlYzwvZGF0

ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwOTUtMTEzNyAoUHJpbnQpJiN4RDswMDk1LTEx

MzcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE1NTgzMjc1PC9hY2Nlc3Npb24tbnVt

Pjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVi

bWVkLzE1NTgzMjc1PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPjUzNTIzODwv

Y3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTEyOC9KQ00uNDIuMTIuNTUxNy01

NTIyLjIwMDQ8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48

QXV0aG9yPk1hZXJ0ZW5zPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48UmVjTnVtPjQ2NjwvUmVj

TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NDY2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0

aW1lc3RhbXA9IjE0MjQ5MTIzMjAiPjQ2Njwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBu

YW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3Jz

PjxhdXRob3I+TWFlcnRlbnMsIEouPC9hdXRob3I+PGF1dGhvcj5NYWVydGVucywgVi48L2F1dGhv

cj48YXV0aG9yPlRoZXVuaXNzZW4sIEsuPC9hdXRob3I+PGF1dGhvcj5NZWVyc3NlbWFuLCBXLjwv

YXV0aG9yPjxhdXRob3I+TWVlcnNzZW1hbiwgUC48L2F1dGhvcj48YXV0aG9yPk1lZXJzLCBTLjwv

YXV0aG9yPjxhdXRob3I+VmVyYmVrZW4sIEUuPC9hdXRob3I+PGF1dGhvcj5WZXJob2VmLCBHLjwv

YXV0aG9yPjxhdXRob3I+VmFuIEVsZGVyZSwgSi48L2F1dGhvcj48YXV0aG9yPkxhZ3JvdSwgSy48

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50

IG9mIEhlbWF0b2xvZ3ksIE1lZGljYWwgSW50ZW5zaXZlIENhcmUgVW5pdCwgVW5pdmVyc2l0eSBI

b3NwaXRhbCBHYXN0aHVpc2JlcmcsIExldXZlbiwgQmVsZ2l1bTwvYXV0aC1hZGRyZXNzPjx0aXRs

ZXM+PHRpdGxlPkJyb25jaG9hbHZlb2xhciBsYXZhZ2UgZmx1aWQgZ2FsYWN0b21hbm5hbiBmb3Ig

dGhlIGRpYWdub3NpcyBvZiBpbnZhc2l2ZSBwdWxtb25hcnkgYXNwZXJnaWxsb3NpcyBpbiBwYXRp

ZW50cyB3aXRoIGhlbWF0b2xvZ2ljIGRpc2Vhc2VzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNs

aW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYWwgaW5mZWN0

aW91cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRoZSBJbmZlY3Rpb3Vz

IERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+

PGFiYnItMT5DbGluLiBJbmZlY3QuIERpcy48L2FiYnItMT48YWJici0yPkNsaW4gSW5mZWN0IERp

czwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MTY4OC05MzwvcGFnZXM+PHZvbHVtZT40OTwv

dm9sdW1lPjxudW1iZXI+MTE8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QnJvbmNob2FsdmVv

bGFyIExhdmFnZSBGbHVpZC8qY2hlbWlzdHJ5PC9rZXl3b3JkPjxrZXl3b3JkPkNhc2UtQ29udHJv

bCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkhlbWF0b2xvZ2ljIERpc2Vhc2VzLypjb21wbGlj

YXRpb25zLyptaWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxr

ZXl3b3JkPkludmFzaXZlIFB1bG1vbmFyeSBBc3BlcmdpbGxvc2lzLypkaWFnbm9zaXM8L2tleXdv

cmQ+PGtleXdvcmQ+TWFubmFucy8qYW5hbHlzaXMvY2hlbWlzdHJ5PC9rZXl3b3JkPjxrZXl3b3Jk

Pk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5

d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRlYyAxPC9kYXRl

PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzNy02NTkxIChFbGVjdHJvbmljKSYjeEQ7MTA1

OC00ODM4IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xOTg4NjgwMTwvYWNjZXNzaW9u

LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8xOTg4NjgwMTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+MTAuMTA4Ni82NDc5MzU8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVj

b3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkQmYXBvcztIYWVzZTwvQXV0aG9yPjxZZWFyPjIwMTI8

L1llYXI+PFJlY051bT40Njc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjQ2NzwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0

NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIxNDI0OTEyNDUwIj40Njc8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkQmYXBvcztIYWVzZSwgSi48L2F1dGhvcj48

YXV0aG9yPlRoZXVuaXNzZW4sIEsuPC9hdXRob3I+PGF1dGhvcj5WZXJtZXVsZW4sIEUuPC9hdXRo

b3I+PGF1dGhvcj5TY2hvZW1hbnMsIEguPC9hdXRob3I+PGF1dGhvcj5EZSBWbGllZ2VyLCBHLjwv

YXV0aG9yPjxhdXRob3I+TGFtbWVydGlqbiwgTC48L2F1dGhvcj48YXV0aG9yPk1lZXJzc2VtYW4s

IFAuPC9hdXRob3I+PGF1dGhvcj5NZWVyc3NlbWFuLCBXLjwvYXV0aG9yPjxhdXRob3I+TGFncm91

LCBLLjwvYXV0aG9yPjxhdXRob3I+TWFlcnRlbnMsIEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29u

dHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBIZW1hdG9sb2d5LCBBY3V0ZSBM

ZXVrZW1pYSBhbmQgU3RlbSBDZWxsIFRyYW5zcGxhbnRhdGlvbiBVbml0LCBVbml2ZXJzaXRhaXJl

IFppZWtlbmh1aXplbiBMZXV2ZW4sIENhbXB1cyBHYXN0aHVpc2JlcmcsIENhdGhvbGljIFVuaXZl

cnNpdHkgb2YgTGV1dmVuLCBMZXV2ZW4sIEJlbGdpdW0uPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48

dGl0bGU+RGV0ZWN0aW9uIG9mIGdhbGFjdG9tYW5uYW4gaW4gYnJvbmNob2FsdmVvbGFyIGxhdmFn

ZSBmbHVpZCBzYW1wbGVzIG9mIHBhdGllbnRzIGF0IHJpc2sgZm9yIGludmFzaXZlIHB1bG1vbmFy

eSBhc3BlcmdpbGxvc2lzOiBhbmFseXRpY2FsIGFuZCBjbGluaWNhbCB2YWxpZGl0eTwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5KIENsaW4gTWljcm9iaW9sPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10

aXRsZT5Kb3VybmFsIG9mIGNsaW5pY2FsIG1pY3JvYmlvbG9neTwvYWx0LXRpdGxlPjwvdGl0bGVz

PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgTWljcm9iaW9sb2d5

PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQ2xpbi4gTWljcm9iaW9sLjwvYWJici0xPjxhYmJyLTI+

SiBDbGluIE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3k8L2Z1bGwtdGl0bGU+PGFi

YnItMT5KLiBDbGluLiBNaWNyb2Jpb2wuPC9hYmJyLTE+PGFiYnItMj5KIENsaW4gTWljcm9iaW9s

PC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTI1OC02MzwvcGFnZXM+PHZvbHVtZT41

MDwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50

PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+

PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+PGtleXdvcmQ+QnJvbmNob2FsdmVv

bGFyIExhdmFnZSBGbHVpZC8qY2hlbWlzdHJ5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkltbXVub2NvbXByb21pc2Vk

IEhvc3Q8L2tleXdvcmQ+PGtleXdvcmQ+SW52YXNpdmUgUHVsbW9uYXJ5IEFzcGVyZ2lsbG9zaXMv

KmRpYWdub3Npcy9pbW11bm9sb2d5L3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9r

ZXl3b3JkPjxrZXl3b3JkPk1hbm5hbnMvKmNoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5NaWRk

bGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5ST0MgQ3VydmU8L2tleXdvcmQ+PGtleXdvcmQ+UmV0

cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPllvdW5nIEFkdWx0PC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHI8

L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDk4LTY2MFggKEVsZWN0cm9uaWMpJiN4

RDswMDk1LTExMzcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyMzAxMDI1PC9hY2Nl

c3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5p

aC5nb3YvcHVibWVkLzIyMzAxMDI1PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20y

PjMzMTg1NjM8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMjgvSkNNLjA2

NDIzLTExPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3Rl

Pn==

ADDIN EN.CITE.DATA [125-128]. Other potential circulating markers for detection of aspergillosis include (1→3)-β-D-glucan (BG) detected by the Tachypleus or Limulus assay PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pc3Ryb3NreS1aZWljaG5lcjwvQXV0aG9yPjxZZWFyPjIw

MDU8L1llYXI+PFJlY051bT4xMjU5PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMjksIDEzMF08L0Rp

c3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTI1OTwvcmVjLW51bWJlcj48Zm9yZWlnbi1r

ZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNm

d3JleCI+MTI1OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFy

dGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+T3N0cm9z

a3ktWmVpY2huZXIsIEwuPC9hdXRob3I+PGF1dGhvcj5BbGV4YW5kZXIsIEIuIEQuPC9hdXRob3I+

PGF1dGhvcj5LZXR0LCBELiBILjwvYXV0aG9yPjxhdXRob3I+VmF6cXVleiwgSi48L2F1dGhvcj48

YXV0aG9yPlBhcHBhcywgUC4gRy48L2F1dGhvcj48YXV0aG9yPlNhZWtpLCBGLjwvYXV0aG9yPjxh

dXRob3I+S2V0Y2h1bSwgUC4gQS48L2F1dGhvcj48YXV0aG9yPldpbmdhcmQsIEouPC9hdXRob3I+

PGF1dGhvcj5TY2hpZmYsIFIuPC9hdXRob3I+PGF1dGhvcj5UYW11cmEsIEguPC9hdXRob3I+PGF1

dGhvcj5GaW5rZWxtYW4sIE0uIEEuPC9hdXRob3I+PGF1dGhvcj5SZXgsIEouIEguPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VW5pdmVyc2l0eSBvZiBUZXhh

cy1Ib3VzdG9uIE1lZGljYWwgU2Nob29sLCBIb3VzdG9uLCBUWCA3NzAzMCwgVVNBLiBMdWlzLk9z

dHJvc2t5LVplaWNobmVyQHV0aC50bWMuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+

TXVsdGljZW50ZXIgY2xpbmljYWwgZXZhbHVhdGlvbiBvZiB0aGUgKDEtLSZndDszKSBiZXRhLUQt

Z2x1Y2FuIGFzc2F5IGFzIGFuIGFpZCB0byBkaWFnbm9zaXMgb2YgZnVuZ2FsIGluZmVjdGlvbnMg

aW4gaHVtYW5zPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlz

ZWFzZXM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGluZmVjdGlvdXMgZGlz

ZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlvbiBvZiB0aGUgSW5mZWN0aW91cyBEaXNlYXNl

cyBTb2NpZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+

Q2xpbiBJbmZlY3QgRGlzPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxwYWdlcz42NTQtOTwvcGFnZXM+

PHZvbHVtZT40MTwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxlZGl0aW9uPjIwMDUvMDgvMDU8

L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8

L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29y

ZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxr

ZXl3b3JkPk15Y29zZXMvIGRpYWdub3Npczwva2V5d29yZD48a2V5d29yZD5SZXByb2R1Y2liaWxp

dHkgb2YgUmVzdWx0czwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNp

dHk8L2tleXdvcmQ+PGtleXdvcmQ+YmV0YS1HbHVjYW5zLyBibG9vZDwva2V5d29yZD48L2tleXdv

cmRzPjxkYXRlcz48eWVhcj4yMDA1PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+U2VwIDE8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU4

LTQ4MzggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE2MDgwMDg3PC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA4Ni80MzI0NzA8

L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9y

ZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+

PC9DaXRlPjxDaXRlPjxBdXRob3I+TGFtb3RoPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

TnVtPjEwOTU8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEwOTU8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJw

dzA1ZmZzZndyZXgiPjEwOTU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkxhbW90aCwgRjwvYXV0aG9yPjxhdXRob3I+Q3J1Y2lhbmksIE08L2F1dGhvcj48YXV0aG9yPk1l

bmdvbGksIEM8L2F1dGhvcj48YXV0aG9yPkNhc3RhZ25vbGEsIEU8L2F1dGhvcj48YXV0aG9yPkxv

cnRob2xhcnksIE88L2F1dGhvcj48YXV0aG9yPlJpY2hhcmRzb24sIE08L2F1dGhvcj48YXV0aG9y

Pk1hcmNoZXR0aSwgTzwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0

aXRsZT48c3R5bGUgZmFjZT0ibm9ybWFsIiBmb250PSJkZWZhdWx0IiBjaGFyc2V0PSIxNjEiIHNp

emU9IjEwMCUiPs6yLUdsdWNhbiBhbnRpZ2VuZW1pYSBhc3NheSBmb3IgdGhlIGRpYWdub3NpcyBv

ZiBpbnZhc2l2ZSBmdW5nYWwgaW5mZWN0aW9ucyBpbiBwYXRpZW50cyB3aXRoIGhlbWF0b2xvZ2lj

YWwgbWFsaWduYW5jaWVzOiBhIHN5c3RlbWF0aWMgcmV2aWV3IGFuZCBtZXRhLWFuYWx5c2lzIG9m

IGNvaG9ydCBzdHVkaWVzIGZyb20gdGhlIFRoaXJkIEV1cm9wZWFuIENvbmZlcmVuY2Ugb24gSW5m

ZWN0aW9ucyBpbiBMZXVrZW1pYSAoRUNJTC0zKTwvc3R5bGU+PC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9m

dWxsLXRpdGxlPjxhYmJyLTE+Q2xpbiBJbmZlY3QgRGlzPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxw

YWdlcz42MzMtNDM8L3BhZ2VzPjx2b2x1bWU+NTQ8L3ZvbHVtZT48ZGF0ZXM+PHllYXI+MjAxMjwv

eWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pc3Ryb3NreS1aZWljaG5lcjwvQXV0aG9yPjxZZWFyPjIw

MDU8L1llYXI+PFJlY051bT4xMjU5PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMjksIDEzMF08L0Rp

c3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTI1OTwvcmVjLW51bWJlcj48Zm9yZWlnbi1r

ZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImZwd2VkMnByOXphdnRqZXRkdGo1ZHRkcnB3MDVmZnNm

d3JleCI+MTI1OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFy

dGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+T3N0cm9z

a3ktWmVpY2huZXIsIEwuPC9hdXRob3I+PGF1dGhvcj5BbGV4YW5kZXIsIEIuIEQuPC9hdXRob3I+

PGF1dGhvcj5LZXR0LCBELiBILjwvYXV0aG9yPjxhdXRob3I+VmF6cXVleiwgSi48L2F1dGhvcj48

YXV0aG9yPlBhcHBhcywgUC4gRy48L2F1dGhvcj48YXV0aG9yPlNhZWtpLCBGLjwvYXV0aG9yPjxh

dXRob3I+S2V0Y2h1bSwgUC4gQS48L2F1dGhvcj48YXV0aG9yPldpbmdhcmQsIEouPC9hdXRob3I+

PGF1dGhvcj5TY2hpZmYsIFIuPC9hdXRob3I+PGF1dGhvcj5UYW11cmEsIEguPC9hdXRob3I+PGF1

dGhvcj5GaW5rZWxtYW4sIE0uIEEuPC9hdXRob3I+PGF1dGhvcj5SZXgsIEouIEguPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VW5pdmVyc2l0eSBvZiBUZXhh

cy1Ib3VzdG9uIE1lZGljYWwgU2Nob29sLCBIb3VzdG9uLCBUWCA3NzAzMCwgVVNBLiBMdWlzLk9z

dHJvc2t5LVplaWNobmVyQHV0aC50bWMuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+

TXVsdGljZW50ZXIgY2xpbmljYWwgZXZhbHVhdGlvbiBvZiB0aGUgKDEtLSZndDszKSBiZXRhLUQt

Z2x1Y2FuIGFzc2F5IGFzIGFuIGFpZCB0byBkaWFnbm9zaXMgb2YgZnVuZ2FsIGluZmVjdGlvbnMg

aW4gaHVtYW5zPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlz

ZWFzZXM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNsaW5pY2FsIGluZmVjdGlvdXMgZGlz

ZWFzZXMgOiBhbiBvZmZpY2lhbCBwdWJsaWNhdGlvbiBvZiB0aGUgSW5mZWN0aW91cyBEaXNlYXNl

cyBTb2NpZXR5IG9mIEFtZXJpY2E8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+

Q2xpbiBJbmZlY3QgRGlzPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxwYWdlcz42NTQtOTwvcGFnZXM+

PHZvbHVtZT40MTwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxlZGl0aW9uPjIwMDUvMDgvMDU8

L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8

L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29y

ZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxr

ZXl3b3JkPk15Y29zZXMvIGRpYWdub3Npczwva2V5d29yZD48a2V5d29yZD5SZXByb2R1Y2liaWxp

dHkgb2YgUmVzdWx0czwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNp

dHk8L2tleXdvcmQ+PGtleXdvcmQ+YmV0YS1HbHVjYW5zLyBibG9vZDwva2V5d29yZD48L2tleXdv

cmRzPjxkYXRlcz48eWVhcj4yMDA1PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+U2VwIDE8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU4

LTQ4MzggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE2MDgwMDg3PC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA4Ni80MzI0NzA8

L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9y

ZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+

PC9DaXRlPjxDaXRlPjxBdXRob3I+TGFtb3RoPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

TnVtPjEwOTU8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEwOTU8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJw

dzA1ZmZzZndyZXgiPjEwOTU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkxhbW90aCwgRjwvYXV0aG9yPjxhdXRob3I+Q3J1Y2lhbmksIE08L2F1dGhvcj48YXV0aG9yPk1l

bmdvbGksIEM8L2F1dGhvcj48YXV0aG9yPkNhc3RhZ25vbGEsIEU8L2F1dGhvcj48YXV0aG9yPkxv

cnRob2xhcnksIE88L2F1dGhvcj48YXV0aG9yPlJpY2hhcmRzb24sIE08L2F1dGhvcj48YXV0aG9y

Pk1hcmNoZXR0aSwgTzwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0

aXRsZT48c3R5bGUgZmFjZT0ibm9ybWFsIiBmb250PSJkZWZhdWx0IiBjaGFyc2V0PSIxNjEiIHNp

emU9IjEwMCUiPs6yLUdsdWNhbiBhbnRpZ2VuZW1pYSBhc3NheSBmb3IgdGhlIGRpYWdub3NpcyBv

ZiBpbnZhc2l2ZSBmdW5nYWwgaW5mZWN0aW9ucyBpbiBwYXRpZW50cyB3aXRoIGhlbWF0b2xvZ2lj

YWwgbWFsaWduYW5jaWVzOiBhIHN5c3RlbWF0aWMgcmV2aWV3IGFuZCBtZXRhLWFuYWx5c2lzIG9m

IGNvaG9ydCBzdHVkaWVzIGZyb20gdGhlIFRoaXJkIEV1cm9wZWFuIENvbmZlcmVuY2Ugb24gSW5m

ZWN0aW9ucyBpbiBMZXVrZW1pYSAoRUNJTC0zKTwvc3R5bGU+PC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9m

dWxsLXRpdGxlPjxhYmJyLTE+Q2xpbiBJbmZlY3QgRGlzPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxw

YWdlcz42MzMtNDM8L3BhZ2VzPjx2b2x1bWU+NTQ8L3ZvbHVtZT48ZGF0ZXM+PHllYXI+MjAxMjwv

eWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [129, 130]. The Tachypleus or Limulus assay used to detect the presence of (1→3)-β-D-glucan is a variation of the limulus assay used to detect endotoxin. The presence of (1→3)-β-D-glucan in serum signifies the presence of fungal invasion but is not specific for Aspergillus species; other fungal diseases, including candidiasis, fusariosis, and Pneumocystis jirovecii pneumonia can result in a positive test. False-positive results can occur in a variety of contexts, such as through glucan contaminated blood collection tubes, gauze, depth-type membrane filters for blood processing, and various drugs (e.g., antibiotics including some cephalosporins, carbapenems, and ampicillin-sulbactam and possibly chemotherapeutics such as PEG asparaginase) ADDIN EN.CITE <EndNote><Cite><Author>Marty</Author><Year>2006</Year><RecNum>1260</RecNum><DisplayText>[131]</DisplayText><record><rec-number>1260</rec-number><foreign-keys><key app="EN" db-id="fpwed2pr9zavtjetdtj5dtdrpw05ffsfwrex">1260</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Marty, F. M.</author><author>Lowry, C. M.</author><author>Lempitski, S. J.</author><author>Kubiak, D. W.</author><author>Finkelman, M. A.</author><author>Baden, L. R.</author></authors></contributors><auth-address>Division of Infectious Diseases, Brigham &amp; Women&apos;s Hospital, Boston, MA 02115, USA. fmarty@</auth-address><titles><title>Reactivity of (1--&gt;3)-beta-d-glucan assay with commonly used intravenous antimicrobials</title><secondary-title>Antimicrobial Agents and Chemotherapy</secondary-title><alt-title>Antimicrobial agents and chemotherapy</alt-title></titles><periodical><full-title>Antimicrobial Agents and Chemotherapy</full-title><abbr-1>Antimicrob Agents Chemother</abbr-1></periodical><alt-periodical><full-title>Antimicrobial Agents and Chemotherapy</full-title><abbr-1>Antimicrob Agents Chemother</abbr-1></alt-periodical><pages>3450-3</pages><volume>50</volume><number>10</number><edition>2006/09/29</edition><keywords><keyword>Anti-Bacterial Agents/administration &amp; dosage/ chemistry</keyword><keyword>False Positive Reactions</keyword><keyword>Humans</keyword><keyword>Injections, Intravenous</keyword><keyword>Mycoses/ diagnosis</keyword><keyword>Reagent Kits, Diagnostic</keyword><keyword>beta-Glucans/ analysis/ blood</keyword></keywords><dates><year>2006</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>0066-4804 (Print)&#xD;0066-4804 (Linking)</isbn><accession-num>17005829</accession-num><urls></urls><custom2>1610103</custom2><electronic-resource-num>10.1128/aac.00658-06</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[131]. The Fungitell assay (Associates of Cape Cod) for detection of (1→3)-β-D-glucan is cleared by the FDA for the diagnosis of invasive mycoses, including aspergillosis, and has been evaluated in high risk patients with hematological malignancy and allogeneic HSCT PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PZGFiYXNpPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48

UmVjTnVtPjExODk8L1JlY051bT48RGlzcGxheVRleHQ+WzEzMiwgMTMzXTwvRGlzcGxheVRleHQ+

PHJlY29yZD48cmVjLW51bWJlcj4xMTg5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMTg5

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5PZGFiYXNpLCBaPC9hdXRo

b3I+PGF1dGhvcj5NYXR0aXV6emksIEc8L2F1dGhvcj48YXV0aG9yPkVzdGV5LCBFPC9hdXRob3I+

PGF1dGhvcj5LYW50YXJqaWFuLCBIPC9hdXRob3I+PGF1dGhvcj5TYWVraSwgRjwvYXV0aG9yPjxh

dXRob3I+UmlkZ2UsIFIgSjwvYXV0aG9yPjxhdXRob3I+S2V0Y2h1bSwgUCBBPC9hdXRob3I+PGF1

dGhvcj5GaW5rZWxtYW4sIE0gQTwvYXV0aG9yPjxhdXRob3I+UmV4LCBKIEg8L2F1dGhvcj48YXV0

aG9yPk9zdHJvc2t5LVplaWNobmVyLCBMPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

Pjx0aXRsZXM+PHRpdGxlPkJldGEtRC1nbHVjYW4gYXMgYSBkaWFnbm9zdGljIGFkanVuY3QgZm9y

IGludmFzaXZlIGZ1bmdhbCBpbmZlY3Rpb25zOiB2YWxpZGF0aW9uLCBjdXRvZmYgZGV2ZWxvcG1l

bnQsIGFuZCBwZXJmb3JtYW5jZSBpbiBwYXRpZW50cyB3aXRoIGFjdXRlIG15ZWxvZ2Vub3VzIGxl

dWtlbWlhIGFuZCBteWVsb2R5c3BsYXN0aWMgc3luZHJvbWU8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+Q2xpbmljYWwgSW5mZWN0aW91cyBEaXNlYXNlczwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVz

PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1

bGwtdGl0bGU+PGFiYnItMT5DbGluIEluZmVjdCBEaXM8L2FiYnItMT48L3BlcmlvZGljYWw+PHBh

Z2VzPjE5OS0yMDU8L3BhZ2VzPjx2b2x1bWU+Mzk8L3ZvbHVtZT48ZGF0ZXM+PHllYXI+MjAwNDwv

eWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5P

c3Ryb3NreS1aZWljaG5lcjwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+PFJlY051bT4xMDMwPC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMDMwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+

PGtleSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4

Ij4xMDMwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNs

ZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Pc3Ryb3NreS1a

ZWljaG5lciwgTDwvYXV0aG9yPjxhdXRob3I+QWxleGFuZGVyLCBCIEQ8L2F1dGhvcj48YXV0aG9y

PktldHQsIEQgSDwvYXV0aG9yPjxhdXRob3I+VmF6cXVleiwgSjwvYXV0aG9yPjxhdXRob3I+UGFw

cGFzLCBQIEc8L2F1dGhvcj48YXV0aG9yPlNhZWtpLCBGPC9hdXRob3I+PGF1dGhvcj5LZXRjaHVt

LCBQIEE8L2F1dGhvcj48YXV0aG9yPldpbmdhcmQsIEo8L2F1dGhvcj48YXV0aG9yPlNjaGlmZiwg

UjwvYXV0aG9yPjxhdXRob3I+VGFtdXJhLCBIPC9hdXRob3I+PGF1dGhvcj5GaW5rZWxtYW4sIE0g

QTwvYXV0aG9yPjxhdXRob3I+UmV4LCBKIEg8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PHRpdGxlcz48dGl0bGU+TXVsdGljZW50ZXIgY2xpbmljYWwgZXZhbHVhdGlvbiBvZiB0aGUg

KDEtLSZndDszKSBiZXRhLUQtZ2x1Y2FuIGFzc2F5IGFzIGFuIGFpZCB0byBkaWFnbm9zaXMgb2Yg

ZnVuZ2FsIGluZmVjdGlvbnMgaW4gaHVtYW5zPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW5p

Y2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxl

PjxhYmJyLTE+Q2xpbiBJbmZlY3QgRGlzPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxwYWdlcz42NTQt

OTwvcGFnZXM+PHZvbHVtZT40MTwvdm9sdW1lPjxkYXRlcz48eWVhcj4yMDA1PC95ZWFyPjwvZGF0

ZXM+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PZGFiYXNpPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48

UmVjTnVtPjExODk8L1JlY051bT48RGlzcGxheVRleHQ+WzEzMiwgMTMzXTwvRGlzcGxheVRleHQ+

PHJlY29yZD48cmVjLW51bWJlcj4xMTg5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4Ij4xMTg5

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5PZGFiYXNpLCBaPC9hdXRo

b3I+PGF1dGhvcj5NYXR0aXV6emksIEc8L2F1dGhvcj48YXV0aG9yPkVzdGV5LCBFPC9hdXRob3I+

PGF1dGhvcj5LYW50YXJqaWFuLCBIPC9hdXRob3I+PGF1dGhvcj5TYWVraSwgRjwvYXV0aG9yPjxh

dXRob3I+UmlkZ2UsIFIgSjwvYXV0aG9yPjxhdXRob3I+S2V0Y2h1bSwgUCBBPC9hdXRob3I+PGF1

dGhvcj5GaW5rZWxtYW4sIE0gQTwvYXV0aG9yPjxhdXRob3I+UmV4LCBKIEg8L2F1dGhvcj48YXV0

aG9yPk9zdHJvc2t5LVplaWNobmVyLCBMPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

Pjx0aXRsZXM+PHRpdGxlPkJldGEtRC1nbHVjYW4gYXMgYSBkaWFnbm9zdGljIGFkanVuY3QgZm9y

IGludmFzaXZlIGZ1bmdhbCBpbmZlY3Rpb25zOiB2YWxpZGF0aW9uLCBjdXRvZmYgZGV2ZWxvcG1l

bnQsIGFuZCBwZXJmb3JtYW5jZSBpbiBwYXRpZW50cyB3aXRoIGFjdXRlIG15ZWxvZ2Vub3VzIGxl

dWtlbWlhIGFuZCBteWVsb2R5c3BsYXN0aWMgc3luZHJvbWU8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+Q2xpbmljYWwgSW5mZWN0aW91cyBEaXNlYXNlczwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVz

PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW5pY2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1

bGwtdGl0bGU+PGFiYnItMT5DbGluIEluZmVjdCBEaXM8L2FiYnItMT48L3BlcmlvZGljYWw+PHBh

Z2VzPjE5OS0yMDU8L3BhZ2VzPjx2b2x1bWU+Mzk8L3ZvbHVtZT48ZGF0ZXM+PHllYXI+MjAwNDwv

eWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5P

c3Ryb3NreS1aZWljaG5lcjwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+PFJlY051bT4xMDMwPC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMDMwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+

PGtleSBhcHA9IkVOIiBkYi1pZD0iZnB3ZWQycHI5emF2dGpldGR0ajVkdGRycHcwNWZmc2Z3cmV4

Ij4xMDMwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNs

ZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Pc3Ryb3NreS1a

ZWljaG5lciwgTDwvYXV0aG9yPjxhdXRob3I+QWxleGFuZGVyLCBCIEQ8L2F1dGhvcj48YXV0aG9y

PktldHQsIEQgSDwvYXV0aG9yPjxhdXRob3I+VmF6cXVleiwgSjwvYXV0aG9yPjxhdXRob3I+UGFw

cGFzLCBQIEc8L2F1dGhvcj48YXV0aG9yPlNhZWtpLCBGPC9hdXRob3I+PGF1dGhvcj5LZXRjaHVt

LCBQIEE8L2F1dGhvcj48YXV0aG9yPldpbmdhcmQsIEo8L2F1dGhvcj48YXV0aG9yPlNjaGlmZiwg

UjwvYXV0aG9yPjxhdXRob3I+VGFtdXJhLCBIPC9hdXRob3I+PGF1dGhvcj5GaW5rZWxtYW4sIE0g

QTwvYXV0aG9yPjxhdXRob3I+UmV4LCBKIEg8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PHRpdGxlcz48dGl0bGU+TXVsdGljZW50ZXIgY2xpbmljYWwgZXZhbHVhdGlvbiBvZiB0aGUg

KDEtLSZndDszKSBiZXRhLUQtZ2x1Y2FuIGFzc2F5IGFzIGFuIGFpZCB0byBkaWFnbm9zaXMgb2Yg

ZnVuZ2FsIGluZmVjdGlvbnMgaW4gaHVtYW5zPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW5p

Y2FsIEluZmVjdGlvdXMgRGlzZWFzZXM8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5DbGluaWNhbCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxl

PjxhYmJyLTE+Q2xpbiBJbmZlY3QgRGlzPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxwYWdlcz42NTQt

OTwvcGFnZXM+PHZvbHVtZT40MTwvdm9sdW1lPjxkYXRlcz48eWVhcj4yMDA1PC95ZWFyPjwvZGF0

ZXM+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [132, 133]. Comparative studies have shown that the Fungitell assay can be slightly more sensitive than GM for IA, but is limited by its poor specificity PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdWxhaGlhbjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+

PFJlY051bT4xMjU0PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMzRdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjEyNTQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJwdzA1ZmZzZndyZXgiPjEyNTQ8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlN1bGFoaWFuLCBBLjwvYXV0aG9y

PjxhdXRob3I+UG9yY2hlciwgUi48L2F1dGhvcj48YXV0aG9yPkJlcmdlcm9uLCBBLjwvYXV0aG9y

PjxhdXRob3I+VG91cmF0aWVyLCBTLjwvYXV0aG9yPjxhdXRob3I+UmFmZm91eCwgRS48L2F1dGhv

cj48YXV0aG9yPk1lbm90dGksIEouPC9hdXRob3I+PGF1dGhvcj5EZXJvdWluLCBGLjwvYXV0aG9y

PjxhdXRob3I+UmliYXVkLCBQLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0

aC1hZGRyZXNzPkxhYm9yYXRvaXJlIGRlIFBhcmFzaXRvbG9naWUtTXljb2xvZ2llLCBVbml2ZXJz

aXRlIFBhcmlzIERpZGVyb3QsIFNvcmJvbm5lIFBhcmlzLUNpdGUsIEFQLUhQIEhvcGl0YWwgU2Fp

bnQtTG91aXMsIFBhcmlzLCBGcmFuY2UgYW5uaWUuc3VsYWhpYW5Ab3JhbmdlLmZyLiYjeEQ7RGVw

YXJ0ZW1lbnQgZGUgQmlvc3RhdGlzdGlxdWUgZXQgZCZhcG9zO0luZm9ybWF0aXF1ZSBNZWRpY2Fs

ZSwgVW5pdmVyc2l0ZSBQYXJpcyBEaWRlcm90LCBTb3Jib25uZSBQYXJpcy1DaXRlLCBBUC1IUCBI

b3BpdGFsIFNhaW50LUxvdWlzLCBQYXJpcywgRnJhbmNlLiYjeEQ7U2VydmljZSBkZSBQbmV1bW9s

b2dpZSwgVW5pdmVyc2l0ZSBQYXJpcyBEaWRlcm90LCBTb3Jib25uZSBQYXJpcy1DaXRlLCBBUC1I

UCBIb3BpdGFsIFNhaW50LUxvdWlzLCBQYXJpcywgRnJhbmNlLiYjeEQ7UGhhcm1hY2llLCBBUC1I

UCBIb3BpdGFsIFNhaW50LUxvdWlzLCBQYXJpcywgRnJhbmNlLiYjeEQ7U2VydmljZSBkZXMgTWFs

YWRpZXMgZHUgU2FuZywgQVAtSFAgSG9waXRhbCBTYWludC1Mb3VpcywgUGFyaXMsIEZyYW5jZS4m

I3hEO0xhYm9yYXRvaXJlIGRlIFBhcmFzaXRvbG9naWUtTXljb2xvZ2llLCBVbml2ZXJzaXRlIFBh

cmlzIERpZGVyb3QsIFNvcmJvbm5lIFBhcmlzLUNpdGUsIEFQLUhQIEhvcGl0YWwgU2FpbnQtTG91

aXMsIFBhcmlzLCBGcmFuY2UuJiN4RDtTZXJ2aWNlIGQmYXBvcztIZW1hdG9sb2dpZS1HcmVmZmUg

ZGUgTW9lbGxlLCBVbml2ZXJzaXRlIFBhcmlzIERpZGVyb3QsIFNvcmJvbm5lIFBhcmlzLUNpdGUs

IEFQLUhQIEhvcGl0YWwgU2FpbnQtTG91aXMsIFBhcmlzLCBGcmFuY2UuPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+VXNlIGFuZCBMaW1pdHMgb2YgKDEtMyktYmV0YS1kLUdsdWNhbiBBc3Nh

eSAoRnVuZ2l0ZWxsKSwgQ29tcGFyZWQgdG8gR2FsYWN0b21hbm5hbiBEZXRlcm1pbmF0aW9uIChQ

bGF0ZWxpYSBBc3BlcmdpbGx1cyksIGZvciBEaWFnbm9zaXMgb2YgSW52YXNpdmUgQXNwZXJnaWxs

b3NpczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE1pY3JvYmlv

bG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Sm91cm5hbCBvZiBjbGluaWNhbCBtaWNy

b2Jpb2xvZ3k8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3Vy

bmFsIG9mIENsaW5pY2FsIE1pY3JvYmlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkogQ2xpbiBN

aWNyb2Jpb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkpvdXJuYWwgb2YgQ2xpbmljYWwgTWljcm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBD

bGluIE1pY3JvYmlvbDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIzMjgtMzM8L3Bh

Z2VzPjx2b2x1bWU+NTI8L3ZvbHVtZT48bnVtYmVyPjc8L251bWJlcj48ZWRpdGlvbj4yMDE0LzA0

LzE4PC9lZGl0aW9uPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVs

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA5OC02NjBYIChFbGVjdHJvbmljKSYj

eEQ7MDA5NS0xMTM3IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNDc0MDA4NDwvYWNj

ZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMjgv

amNtLjAzNTY3LTEzPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXBy

b3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1

YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdWxhaGlhbjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+

PFJlY051bT4xMjU0PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMzRdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjEyNTQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSJmcHdlZDJwcjl6YXZ0amV0ZHRqNWR0ZHJwdzA1ZmZzZndyZXgiPjEyNTQ8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlN1bGFoaWFuLCBBLjwvYXV0aG9y

PjxhdXRob3I+UG9yY2hlciwgUi48L2F1dGhvcj48YXV0aG9yPkJlcmdlcm9uLCBBLjwvYXV0aG9y

PjxhdXRob3I+VG91cmF0aWVyLCBTLjwvYXV0aG9yPjxhdXRob3I+UmFmZm91eCwgRS48L2F1dGhv

cj48YXV0aG9yPk1lbm90dGksIEouPC9hdXRob3I+PGF1dGhvcj5EZXJvdWluLCBGLjwvYXV0aG9y

PjxhdXRob3I+UmliYXVkLCBQLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0

aC1hZGRyZXNzPkxhYm9yYXRvaXJlIGRlIFBhcmFzaXRvbG9naWUtTXljb2xvZ2llLCBVbml2ZXJz

aXRlIFBhcmlzIERpZGVyb3QsIFNvcmJvbm5lIFBhcmlzLUNpdGUsIEFQLUhQIEhvcGl0YWwgU2Fp

bnQtTG91aXMsIFBhcmlzLCBGcmFuY2UgYW5uaWUuc3VsYWhpYW5Ab3JhbmdlLmZyLiYjeEQ7RGVw

YXJ0ZW1lbnQgZGUgQmlvc3RhdGlzdGlxdWUgZXQgZCZhcG9zO0luZm9ybWF0aXF1ZSBNZWRpY2Fs

ZSwgVW5pdmVyc2l0ZSBQYXJpcyBEaWRlcm90LCBTb3Jib25uZSBQYXJpcy1DaXRlLCBBUC1IUCBI

b3BpdGFsIFNhaW50LUxvdWlzLCBQYXJpcywgRnJhbmNlLiYjeEQ7U2VydmljZSBkZSBQbmV1bW9s

b2dpZSwgVW5pdmVyc2l0ZSBQYXJpcyBEaWRlcm90LCBTb3Jib25uZSBQYXJpcy1DaXRlLCBBUC1I

UCBIb3BpdGFsIFNhaW50LUxvdWlzLCBQYXJpcywgRnJhbmNlLiYjeEQ7UGhhcm1hY2llLCBBUC1I

UCBIb3BpdGFsIFNhaW50LUxvdWlzLCBQYXJpcywgRnJhbmNlLiYjeEQ7U2VydmljZSBkZXMgTWFs

YWRpZXMgZHUgU2FuZywgQVAtSFAgSG9waXRhbCBTYWludC1Mb3VpcywgUGFyaXMsIEZyYW5jZS4m

I3hEO0xhYm9yYXRvaXJlIGRlIFBhcmFzaXRvbG9naWUtTXljb2xvZ2llLCBVbml2ZXJzaXRlIFBh

cmlzIERpZGVyb3QsIFNvcmJvbm5lIFBhcmlzLUNpdGUsIEFQLUhQIEhvcGl0YWwgU2FpbnQtTG91

aXMsIFBhcmlzLCBGcmFuY2UuJiN4RDtTZXJ2aWNlIGQmYXBvcztIZW1hdG9sb2dpZS1HcmVmZmUg

ZGUgTW9lbGxlLCBVbml2ZXJzaXRlIFBhcmlzIERpZGVyb3QsIFNvcmJvbm5lIFBhcmlzLUNpdGUs

IEFQLUhQIEhvcGl0YWwgU2FpbnQtTG91aXMsIFBhcmlzLCBGcmFuY2UuPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+VXNlIGFuZCBMaW1pdHMgb2YgKDEtMyktYmV0YS1kLUdsdWNhbiBBc3Nh

eSAoRnVuZ2l0ZWxsKSwgQ29tcGFyZWQgdG8gR2FsYWN0b21hbm5hbiBEZXRlcm1pbmF0aW9uIChQ

bGF0ZWxpYSBBc3BlcmdpbGx1cyksIGZvciBEaWFnbm9zaXMgb2YgSW52YXNpdmUgQXNwZXJnaWxs

b3NpczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE1pY3JvYmlv

bG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Sm91cm5hbCBvZiBjbGluaWNhbCBtaWNy

b2Jpb2xvZ3k8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3Vy

bmFsIG9mIENsaW5pY2FsIE1pY3JvYmlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkogQ2xpbiBN

aWNyb2Jpb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkpvdXJuYWwgb2YgQ2xpbmljYWwgTWljcm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBD

bGluIE1pY3JvYmlvbDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIzMjgtMzM8L3Bh

Z2VzPjx2b2x1bWU+NTI8L3ZvbHVtZT48bnVtYmVyPjc8L251bWJlcj48ZWRpdGlvbj4yMDE0LzA0

LzE4PC9lZGl0aW9uPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVs

PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA5OC02NjBYIChFbGVjdHJvbmljKSYj

eEQ7MDA5NS0xMTM3IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNDc0MDA4NDwvYWNj

ZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMjgv

amNtLjAzNTY3LTEzPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXBy

b3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1

YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [134], while others have found that Fungitell is not as helpful for IA ADDIN EN.CITE <EndNote><Cite><Author>Badiee</Author><Year>2012</Year><RecNum>813</RecNum><DisplayText>[111]</DisplayText><record><rec-number>813</rec-number><foreign-keys><key app="EN" db-id="25ws99rfnw2zfmert5rxzapsprpa5wr2efdr" timestamp="1454372726">813</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Badiee, P.</author><author>Alborzi, A.</author><author>Karimi, M.</author><author>Pourabbas, B.</author><author>Haddadi, P.</author><author>Mardaneh, J.</author><author>Moieni, M.</author></authors></contributors><auth-address>Prof. Alborzi Clinical Microbiology Research Center, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. badieep@</auth-address><titles><title>Diagnostic potential of nested PCR, galactomannan EIA, and beta-D-glucan for invasive aspergillosis in pediatric patients</title><secondary-title>J Infect Dev Ctries</secondary-title></titles><periodical><full-title>J Infect Dev Ctries</full-title></periodical><pages>352-7</pages><volume>6</volume><number>4</number><keywords><keyword>Adolescent</keyword><keyword>Aspergillus/chemistry/genetics/*isolation &amp; purification</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Clinical Laboratory Techniques/*methods</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Immunoenzyme Techniques/*methods</keyword><keyword>Infant</keyword><keyword>Invasive Pulmonary Aspergillosis/*diagnosis/microbiology</keyword><keyword>Male</keyword><keyword>Mannans/analysis</keyword><keyword>Polymerase Chain Reaction/*methods</keyword><keyword>Reagent Kits, Diagnostic</keyword><keyword>beta-Glucans/analysis</keyword></keywords><dates><year>2012</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>1972-2680 (Electronic)&#xD;1972-2680 (Linking)</isbn><accession-num>22505446</accession-num><urls><related-urls><url>;[111]. However, another study in a large cancer center that compared GM and (13)--D-glucan assays prospectively over a three-year period in 82 patients, each for 12 weeks found that the (13)--D-glucan assay was more sensitive than the GM assays for detection of IA and other mould infections in patients with hematological malignancy PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWNoZW08L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

ZWNOdW0+NjQwPC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMzVdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjY0MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIx

NDM5MzE1MTA1Ij42NDA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkhh

Y2hlbSwgUi4gWS48L2F1dGhvcj48YXV0aG9yPktvbnRveWlhbm5pcywgRC4gUC48L2F1dGhvcj48

YXV0aG9yPkNoZW1hbHksIFIuIEYuPC9hdXRob3I+PGF1dGhvcj5KaWFuZywgWS48L2F1dGhvcj48

YXV0aG9yPlJlaXR6ZWwsIFIuPC9hdXRob3I+PGF1dGhvcj5SYWFkLCBJLjwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgSW5mZWN0aW91

cyBEaXNlYXNlcywgSW5mZWN0aW9uIENvbnRyb2wgYW5kIEVtcGxveWVlIEhlYWx0aCwgVW5pdCA0

MDIsIFRoZSBVbml2ZXJzaXR5IG9mIFRleGFzIE0uIEQuIEFuZGVyc29uIENhbmNlciBDZW50ZXIs

IDE1MTUgSG9sY29tYmUgQmx2ZC4sIEhvdXN0b24sIFRYIDc3MDMwLCBVU0EuIHJoYWNoZW1AbWRh

bmRlcnNvbi5vcmc8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5VdGlsaXR5IG9mIGdhbGFj

dG9tYW5uYW4gZW56eW1lIGltbXVub2Fzc2F5IGFuZCAoMSwzKSBiZXRhLUQtZ2x1Y2FuIGluIGRp

YWdub3NpcyBvZiBpbnZhc2l2ZSBmdW5nYWwgaW5mZWN0aW9uczogbG93IHNlbnNpdGl2aXR5IGZv

ciBBc3BlcmdpbGx1cyBmdW1pZ2F0dXMgaW5mZWN0aW9uIGluIGhlbWF0b2xvZ2ljIG1hbGlnbmFu

Y3kgcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBDbGluIE1pY3JvYmlvbDwvc2Vj

b25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2Yg

Q2xpbmljYWwgTWljcm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQ2xpbi4gTWljcm9i

aW9sLjwvYWJici0xPjxhYmJyLTI+SiBDbGluIE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNh

bD48cGFnZXM+MTI5LTMzPC9wYWdlcz48dm9sdW1lPjQ3PC92b2x1bWU+PG51bWJlcj4xPC9udW1i

ZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8

L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zl

cjwva2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdv

cmQ+PGtleXdvcmQ+SGVtYXRvbG9naWMgTmVvcGxhc21zL2NvbXBsaWNhdGlvbnM8L2tleXdvcmQ+

PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub2VuenltZSBUZWNobmlxdWVz

L21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5z

LypibG9vZDwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5N

eWNvc2VzLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNp

ZmljaXR5PC9rZXl3b3JkPjxrZXl3b3JkPmJldGEtR2x1Y2Fucy8qYmxvb2Q8L2tleXdvcmQ+PC9r

ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkphbjwvZGF0

ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwOTgtNjYwWCAoRWxlY3Ryb25pYykmI3hEOzAw

OTUtMTEzNyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTkwMDUxNDU8L2FjY2Vzc2lv

bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMTkwMDUxNDU8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1D

MjYyMDg4MjwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTEyOC9KQ00uMDA1

MDYtMDg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWNoZW08L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

ZWNOdW0+NjQwPC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMzVdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjY0MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1wPSIx

NDM5MzE1MTA1Ij42NDA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkhh

Y2hlbSwgUi4gWS48L2F1dGhvcj48YXV0aG9yPktvbnRveWlhbm5pcywgRC4gUC48L2F1dGhvcj48

YXV0aG9yPkNoZW1hbHksIFIuIEYuPC9hdXRob3I+PGF1dGhvcj5KaWFuZywgWS48L2F1dGhvcj48

YXV0aG9yPlJlaXR6ZWwsIFIuPC9hdXRob3I+PGF1dGhvcj5SYWFkLCBJLjwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgSW5mZWN0aW91

cyBEaXNlYXNlcywgSW5mZWN0aW9uIENvbnRyb2wgYW5kIEVtcGxveWVlIEhlYWx0aCwgVW5pdCA0

MDIsIFRoZSBVbml2ZXJzaXR5IG9mIFRleGFzIE0uIEQuIEFuZGVyc29uIENhbmNlciBDZW50ZXIs

IDE1MTUgSG9sY29tYmUgQmx2ZC4sIEhvdXN0b24sIFRYIDc3MDMwLCBVU0EuIHJoYWNoZW1AbWRh

bmRlcnNvbi5vcmc8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5VdGlsaXR5IG9mIGdhbGFj

dG9tYW5uYW4gZW56eW1lIGltbXVub2Fzc2F5IGFuZCAoMSwzKSBiZXRhLUQtZ2x1Y2FuIGluIGRp

YWdub3NpcyBvZiBpbnZhc2l2ZSBmdW5nYWwgaW5mZWN0aW9uczogbG93IHNlbnNpdGl2aXR5IGZv

ciBBc3BlcmdpbGx1cyBmdW1pZ2F0dXMgaW5mZWN0aW9uIGluIGhlbWF0b2xvZ2ljIG1hbGlnbmFu

Y3kgcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBDbGluIE1pY3JvYmlvbDwvc2Vj

b25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2Yg

Q2xpbmljYWwgTWljcm9iaW9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQ2xpbi4gTWljcm9i

aW9sLjwvYWJici0xPjxhYmJyLTI+SiBDbGluIE1pY3JvYmlvbDwvYWJici0yPjwvcGVyaW9kaWNh

bD48cGFnZXM+MTI5LTMzPC9wYWdlcz48dm9sdW1lPjQ3PC92b2x1bWU+PG51bWJlcj4xPC9udW1i

ZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8

L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zl

cjwva2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdv

cmQ+PGtleXdvcmQ+SGVtYXRvbG9naWMgTmVvcGxhc21zL2NvbXBsaWNhdGlvbnM8L2tleXdvcmQ+

PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkltbXVub2VuenltZSBUZWNobmlxdWVz

L21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5z

LypibG9vZDwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5N

eWNvc2VzLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNp

ZmljaXR5PC9rZXl3b3JkPjxrZXl3b3JkPmJldGEtR2x1Y2Fucy8qYmxvb2Q8L2tleXdvcmQ+PC9r

ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkphbjwvZGF0

ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwOTgtNjYwWCAoRWxlY3Ryb25pYykmI3hEOzAw

OTUtMTEzNyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTkwMDUxNDU8L2FjY2Vzc2lv

bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMTkwMDUxNDU8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1D

MjYyMDg4MjwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTEyOC9KQ00uMDA1

MDYtMDg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [135]. One meta-analysis of BG assays revealed limitations ADDIN EN.CITE <EndNote><Cite><Author>Lamoth</Author><Year>2012</Year><RecNum>1256</RecNum><DisplayText>[136]</DisplayText><record><rec-number>1256</rec-number><foreign-keys><key app="EN" db-id="fpwed2pr9zavtjetdtj5dtdrpw05ffsfwrex">1256</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lamoth, F.</author><author>Cruciani, M.</author><author>Mengoli, C.</author><author>Castagnola, E.</author><author>Lortholary, O.</author><author>Richardson, M.</author><author>Marchetti, O.</author></authors></contributors><auth-address>Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland.</auth-address><titles><title>beta-Glucan antigenemia assay for the diagnosis of invasive fungal infections in patients with hematological malignancies: a systematic review and meta-analysis of cohort studies from the Third European Conference on Infections in Leukemia (ECIL-3)</title><secondary-title>Clinical Infectious Diseases</secondary-title><alt-title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</alt-title></titles><periodical><full-title>Clinical Infectious Diseases</full-title><abbr-1>Clin Infect Dis</abbr-1></periodical><pages>633-43</pages><volume>54</volume><number>5</number><edition>2011/12/27</edition><keywords><keyword>Hematologic Neoplasms/ complications</keyword><keyword>Humans</keyword><keyword>Mycoses/ complications/ diagnosis</keyword><keyword>Reproducibility of Results</keyword><keyword>Sensitivity and Specificity</keyword><keyword>beta-Glucans/ blood</keyword></keywords><dates><year>2012</year><pub-dates><date>Mar 1</date></pub-dates></dates><isbn>1537-6591 (Electronic)&#xD;1058-4838 (Linking)</isbn><accession-num>22198786</accession-num><urls></urls><electronic-resource-num>10.1093/cid/cir897</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[136], while another found similar deficiencies yet improvement in diagnostic capabilities with the combination of both biomarkers PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXpvczwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+PFJl

Y051bT42NDE8L1JlY051bT48RGlzcGxheVRleHQ+WzEzN108L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NjQxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9IjE0

MzkzMTUxODciPjY0MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UGF6

b3MsIEMuPC9hdXRob3I+PGF1dGhvcj5Qb250b24sIEouPC9hdXRob3I+PGF1dGhvcj5EZWwgUGFs

YWNpbywgQS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5V

bmlkYWQgZGUgTWljb2xvZ2lhLCBEZXBhcnRhbWVudG8gZGUgTWljcm9iaW9sb2dpYSwgSG9zcGl0

YWwgVW5pdmVyc2l0YXJpbyAxMiBkZSBPY3R1YnJlLCBBdmVuaWRhIGRlIENvcmRvYmEgcy9uLCAy

ODA0MSBNYWRyaWQsIFNwYWluLiBwYXpvcy5jQHRlcnJhLmVzPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+Q29udHJpYnV0aW9uIG9mICgxLSZndDszKS1iZXRhLUQtZ2x1Y2FuIGNocm9tb2dl

bmljIGFzc2F5IHRvIGRpYWdub3NpcyBhbmQgdGhlcmFwZXV0aWMgbW9uaXRvcmluZyBvZiBpbnZh

c2l2ZSBhc3BlcmdpbGxvc2lzIGluIG5ldXRyb3BlbmljIGFkdWx0IHBhdGllbnRzOiBhIGNvbXBh

cmlzb24gd2l0aCBzZXJpYWwgc2NyZWVuaW5nIGZvciBjaXJjdWxhdGluZyBnYWxhY3RvbWFubmFu

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQ2xpbiBNaWNyb2Jpb2w8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE1p

Y3JvYmlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkouIENsaW4uIE1pY3JvYmlvbC48L2FiYnIt

MT48YWJici0yPkogQ2xpbiBNaWNyb2Jpb2w8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjI5

OS0zMDU8L3BhZ2VzPjx2b2x1bWU+NDM8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48a2V5d29y

ZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48

a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlmdW5nYWwgQWdlbnRzL3RoZXJhcGV1

dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzLypkaWFnbm9zaXMvZHJ1ZyB0

aGVyYXB5L21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy9tZXRhYm9s

aXNtPC9rZXl3b3JkPjxrZXl3b3JkPkNocm9tb2dlbmljIENvbXBvdW5kcy8qbWV0YWJvbGlzbTwv

a2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3Jk

PjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8qYmxvb2Q8L2tleXdvcmQ+

PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TmV1dHJvcGVuaWEvKmNvbXBs

aWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+UHJlZGljdGl2ZSBWYWx1ZSBvZiBUZXN0czwva2V5

d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtleXdv

cmQ+YmV0YS1HbHVjYW5zLypibG9vZDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDA1PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MDA5NS0xMTM3IChQcmludCkmI3hEOzAwOTUtMTEzNyAoTGlua2luZyk8L2lzYm4+PGFj

Y2Vzc2lvbi1udW0+MTU2MzQ5ODY8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48

dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTU2MzQ5ODY8L3VybD48L3Jl

bGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1DNTQwMTY1PC9jdXN0b20yPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT4xMC4xMTI4L0pDTS40My4xLjI5OS0zMDUuMjAwNTwvZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXpvczwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+PFJl

Y051bT42NDE8L1JlY051bT48RGlzcGxheVRleHQ+WzEzN108L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NjQxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iMjV3czk5cmZudzJ6Zm1lcnQ1cnh6YXBzcHJwYTV3cjJlZmRyIiB0aW1lc3RhbXA9IjE0

MzkzMTUxODciPjY0MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UGF6

b3MsIEMuPC9hdXRob3I+PGF1dGhvcj5Qb250b24sIEouPC9hdXRob3I+PGF1dGhvcj5EZWwgUGFs

YWNpbywgQS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5V

bmlkYWQgZGUgTWljb2xvZ2lhLCBEZXBhcnRhbWVudG8gZGUgTWljcm9iaW9sb2dpYSwgSG9zcGl0

YWwgVW5pdmVyc2l0YXJpbyAxMiBkZSBPY3R1YnJlLCBBdmVuaWRhIGRlIENvcmRvYmEgcy9uLCAy

ODA0MSBNYWRyaWQsIFNwYWluLiBwYXpvcy5jQHRlcnJhLmVzPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+Q29udHJpYnV0aW9uIG9mICgxLSZndDszKS1iZXRhLUQtZ2x1Y2FuIGNocm9tb2dl

bmljIGFzc2F5IHRvIGRpYWdub3NpcyBhbmQgdGhlcmFwZXV0aWMgbW9uaXRvcmluZyBvZiBpbnZh

c2l2ZSBhc3BlcmdpbGxvc2lzIGluIG5ldXRyb3BlbmljIGFkdWx0IHBhdGllbnRzOiBhIGNvbXBh

cmlzb24gd2l0aCBzZXJpYWwgc2NyZWVuaW5nIGZvciBjaXJjdWxhdGluZyBnYWxhY3RvbWFubmFu

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQ2xpbiBNaWNyb2Jpb2w8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE1p

Y3JvYmlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkouIENsaW4uIE1pY3JvYmlvbC48L2FiYnIt

MT48YWJici0yPkogQ2xpbiBNaWNyb2Jpb2w8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjI5

OS0zMDU8L3BhZ2VzPjx2b2x1bWU+NDM8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48a2V5d29y

ZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48

a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlmdW5nYWwgQWdlbnRzL3RoZXJhcGV1

dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzLypkaWFnbm9zaXMvZHJ1ZyB0

aGVyYXB5L21pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGx1cy9tZXRhYm9s

aXNtPC9rZXl3b3JkPjxrZXl3b3JkPkNocm9tb2dlbmljIENvbXBvdW5kcy8qbWV0YWJvbGlzbTwv

a2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3Jk

PjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8qYmxvb2Q8L2tleXdvcmQ+

PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TmV1dHJvcGVuaWEvKmNvbXBs

aWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+UHJlZGljdGl2ZSBWYWx1ZSBvZiBUZXN0czwva2V5

d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtleXdv

cmQ+YmV0YS1HbHVjYW5zLypibG9vZDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDA1PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MDA5NS0xMTM3IChQcmludCkmI3hEOzAwOTUtMTEzNyAoTGlua2luZyk8L2lzYm4+PGFj

Y2Vzc2lvbi1udW0+MTU2MzQ5ODY8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48

dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTU2MzQ5ODY8L3VybD48L3Jl

bGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1DNTQwMTY1PC9jdXN0b20yPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT4xMC4xMTI4L0pDTS40My4xLjI5OS0zMDUuMjAwNTwvZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA [137]. Other organizations have recommended the GM over Fungitell for specifically diagnosing IA PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJjaGV0dGk8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFy

PjxSZWNOdW0+ODE2PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMzhdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjgxNjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1w

PSIxNDU0MzczOTAwIj44MTY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

Pk1hcmNoZXR0aSwgTy48L2F1dGhvcj48YXV0aG9yPkxhbW90aCwgRi48L2F1dGhvcj48YXV0aG9y

Pk1pa3Vsc2thLCBNLjwvYXV0aG9yPjxhdXRob3I+VmlzY29saSwgQy48L2F1dGhvcj48YXV0aG9y

PlZlcndlaWosIFAuPC9hdXRob3I+PGF1dGhvcj5CcmV0YWduZSwgUy48L2F1dGhvcj48YXV0aG9y

PkV1cm9wZWFuIENvbmZlcmVuY2Ugb24gSW5mZWN0aW9ucyBpbiBMZXVrZW1pYSBMYWJvcmF0b3J5

IFdvcmtpbmcsIEdyb3VwczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1h

ZGRyZXNzPkluZmVjdGlvdXMgRGlzZWFzZXMgU2VydmljZSwgRGVwYXJ0bWVudCBvZiBNZWRpY2lu

ZSwgQ2VudHJlIEhvc3BpdGFsaWVyIFVuaXZlcnNpdGFpcmUgVmF1ZG9pcyBhbmQgVW5pdmVyc2l0

eSBvZiBMYXVzYW5uZSwgTGF1c2FubmUsIFN3aXR6ZXJsYW5kLjwvYXV0aC1hZGRyZXNzPjx0aXRs

ZXM+PHRpdGxlPkVDSUwgcmVjb21tZW5kYXRpb25zIGZvciB0aGUgdXNlIG9mIGJpb2xvZ2ljYWwg

bWFya2VycyBmb3IgdGhlIGRpYWdub3NpcyBvZiBpbnZhc2l2ZSBmdW5nYWwgZGlzZWFzZXMgaW4g

bGV1a2VtaWMgcGF0aWVudHMgYW5kIGhlbWF0b3BvaWV0aWMgU0NUIHJlY2lwaWVudHM8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+Qm9uZSBNYXJyb3cgVHJhbnNwbGFudDwvc2Vjb25kYXJ5LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJvbmUgTWFycm93IFRyYW5zcGxhbnRh

dGlvbjwvZnVsbC10aXRsZT48YWJici0xPkJvbmUgTWFycm93IFRyYW5zcGxhbnQuPC9hYmJyLTE+

PGFiYnItMj5Cb25lIE1hcnJvdyBUcmFuc3BsYW50PC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdl

cz44NDYtNTQ8L3BhZ2VzPjx2b2x1bWU+NDc8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48a2V5

d29yZHM+PGtleXdvcmQ+KkFudGlnZW5zLCBGdW5nYWwvYmxvb2QvY2VyZWJyb3NwaW5hbCBmbHVp

ZDwva2V5d29yZD48a2V5d29yZD5CaW9tYXJrZXJzL2Jsb29kL2NlcmVicm9zcGluYWwgZmx1aWQ8

L2tleXdvcmQ+PGtleXdvcmQ+Q29uZ3Jlc3NlcyBhcyBUb3BpYzwva2V5d29yZD48a2V5d29yZD5F

dXJvcGVhbiBVbmlvbjwva2V5d29yZD48a2V5d29yZD4qSGVtYXRvcG9pZXRpYyBTdGVtIENlbGwg

VHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkxldWtlbWlhLypibG9vZC8qY2VyZWJy

b3NwaW5hbCBmbHVpZC9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Kk1hbm5hbnMvYmxv

b2QvY2VyZWJyb3NwaW5hbCBmbHVpZDwva2V5d29yZD48a2V5d29yZD4qTXljb3Nlcy9ibG9vZC9j

ZXJlYnJvc3BpbmFsIGZsdWlkL2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlRy

YW5zcGxhbnRhdGlvbiwgSG9tb2xvZ291czwva2V5d29yZD48a2V5d29yZD4qYmV0YS1HbHVjYW5z

L2Jsb29kL2NlcmVicm9zcGluYWwgZmx1aWQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHll

YXI+MjAxMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh

dGVzPjxpc2JuPjE0NzYtNTM2NSAoRWxlY3Ryb25pYykmI3hEOzAyNjgtMzM2OSAoTGlua2luZyk8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjE5MjcwMzQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0

ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjE5MjcwMzQ8

L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEw

MzgvYm10LjIwMTEuMTc4PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+

PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJjaGV0dGk8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFy

PjxSZWNOdW0+ODE2PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMzhdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjgxNjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1w

PSIxNDU0MzczOTAwIj44MTY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

Pk1hcmNoZXR0aSwgTy48L2F1dGhvcj48YXV0aG9yPkxhbW90aCwgRi48L2F1dGhvcj48YXV0aG9y

Pk1pa3Vsc2thLCBNLjwvYXV0aG9yPjxhdXRob3I+VmlzY29saSwgQy48L2F1dGhvcj48YXV0aG9y

PlZlcndlaWosIFAuPC9hdXRob3I+PGF1dGhvcj5CcmV0YWduZSwgUy48L2F1dGhvcj48YXV0aG9y

PkV1cm9wZWFuIENvbmZlcmVuY2Ugb24gSW5mZWN0aW9ucyBpbiBMZXVrZW1pYSBMYWJvcmF0b3J5

IFdvcmtpbmcsIEdyb3VwczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1h

ZGRyZXNzPkluZmVjdGlvdXMgRGlzZWFzZXMgU2VydmljZSwgRGVwYXJ0bWVudCBvZiBNZWRpY2lu

ZSwgQ2VudHJlIEhvc3BpdGFsaWVyIFVuaXZlcnNpdGFpcmUgVmF1ZG9pcyBhbmQgVW5pdmVyc2l0

eSBvZiBMYXVzYW5uZSwgTGF1c2FubmUsIFN3aXR6ZXJsYW5kLjwvYXV0aC1hZGRyZXNzPjx0aXRs

ZXM+PHRpdGxlPkVDSUwgcmVjb21tZW5kYXRpb25zIGZvciB0aGUgdXNlIG9mIGJpb2xvZ2ljYWwg

bWFya2VycyBmb3IgdGhlIGRpYWdub3NpcyBvZiBpbnZhc2l2ZSBmdW5nYWwgZGlzZWFzZXMgaW4g

bGV1a2VtaWMgcGF0aWVudHMgYW5kIGhlbWF0b3BvaWV0aWMgU0NUIHJlY2lwaWVudHM8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+Qm9uZSBNYXJyb3cgVHJhbnNwbGFudDwvc2Vjb25kYXJ5LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJvbmUgTWFycm93IFRyYW5zcGxhbnRh

dGlvbjwvZnVsbC10aXRsZT48YWJici0xPkJvbmUgTWFycm93IFRyYW5zcGxhbnQuPC9hYmJyLTE+

PGFiYnItMj5Cb25lIE1hcnJvdyBUcmFuc3BsYW50PC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdl

cz44NDYtNTQ8L3BhZ2VzPjx2b2x1bWU+NDc8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48a2V5

d29yZHM+PGtleXdvcmQ+KkFudGlnZW5zLCBGdW5nYWwvYmxvb2QvY2VyZWJyb3NwaW5hbCBmbHVp

ZDwva2V5d29yZD48a2V5d29yZD5CaW9tYXJrZXJzL2Jsb29kL2NlcmVicm9zcGluYWwgZmx1aWQ8

L2tleXdvcmQ+PGtleXdvcmQ+Q29uZ3Jlc3NlcyBhcyBUb3BpYzwva2V5d29yZD48a2V5d29yZD5F

dXJvcGVhbiBVbmlvbjwva2V5d29yZD48a2V5d29yZD4qSGVtYXRvcG9pZXRpYyBTdGVtIENlbGwg

VHJhbnNwbGFudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkxldWtlbWlhLypibG9vZC8qY2VyZWJy

b3NwaW5hbCBmbHVpZC9taWNyb2Jpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Kk1hbm5hbnMvYmxv

b2QvY2VyZWJyb3NwaW5hbCBmbHVpZDwva2V5d29yZD48a2V5d29yZD4qTXljb3Nlcy9ibG9vZC9j

ZXJlYnJvc3BpbmFsIGZsdWlkL2RpYWdub3Npcy90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlRy

YW5zcGxhbnRhdGlvbiwgSG9tb2xvZ291czwva2V5d29yZD48a2V5d29yZD4qYmV0YS1HbHVjYW5z

L2Jsb29kL2NlcmVicm9zcGluYWwgZmx1aWQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHll

YXI+MjAxMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh

dGVzPjxpc2JuPjE0NzYtNTM2NSAoRWxlY3Ryb25pYykmI3hEOzAyNjgtMzM2OSAoTGlua2luZyk8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjE5MjcwMzQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0

ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjE5MjcwMzQ8

L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEw

MzgvYm10LjIwMTEuMTc4PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+

PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [138].What is the approach to the radiographic diagnosis of IPA?Recommendations13.We recommend performing a chest computed tomographic (CT) scan whenever there is a clinical suspicion for IPA regardless of chest radiograph results (Strong Recommendation; High Quality Evidence). 14.Routine use of contrast during a chest CT scan for a suspicion of IPA is not recommended (Strong Recommendation; Moderate Quality Evidence). Contrast is recommended when a nodule or a mass is close to a large vessel (Strong Recommendation; Moderate Quality Evidence). 15.We suggest a follow-up chest CT-scan to assess the response of IPA to treatment after a minimum of two weeks of treatment; earlier assessment is indicated if the patient clinically deteriorates (Weak Recommendation; Low Quality Evidence). When a nodule is close to a large vessel, more frequent monitoring may be required (Weak Recommendation; Low Quality Evidence).Evidence summaryAs clinical signs and symptoms are not specific for the diagnosis of IPA, radiographic imaging is critical. The role of imaging is to identify the site of infection, to assess the type, number and size of lesions, and local extension. Imaging also helps to direct diagnostic procedures (e.g. BAL or CT-guided biopsy) to the most appropriate area PEVuZE5vdGU+PENpdGUgRXhjbHVkZVllYXI9IjEiPjxBdXRob3I+QmVja2VyPC9BdXRob3I+PFll

YXI+MjAwMzwvWWVhcj48UmVjTnVtPjY3ODc3PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMzldPC9E

aXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjY3ODc3PC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZjJweHZ6MmZ4ZHd2cjRlMnBhZnBwZXMxYWV3ZDl2

ZHNlZno1IiB0aW1lc3RhbXA9IjEzOTk3MzA1MDIiPjY3ODc3PC9rZXk+PC9mb3JlaWduLWtleXM+

PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRv

cnM+PGF1dGhvcnM+PGF1dGhvcj5CZWNrZXIsIE0uIEouPC9hdXRob3I+PGF1dGhvcj5MdWd0ZW5i

dXJnLCBFLiBKLjwvYXV0aG9yPjxhdXRob3I+Q29ybmVsaXNzZW4sIEouIEouPC9hdXRob3I+PGF1

dGhvcj5WYW4gRGVyIFNjaGVlLCBDLjwvYXV0aG9yPjxhdXRob3I+SG9vZ3N0ZWRlbiwgSC4gQy48

L2F1dGhvcj48YXV0aG9yPkRlIE1hcmllLCBTLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgTWVkaWNhbCBNaWNyb2Jpb2xvZ3kgYW5k

IEluZmVjdGlvdXMgRGlzZWFzZXMsIEVyYXNtdXMgTWVkaWNhbCBDZW50cmUgUm90dGVyZGFtLCB0

aGUgTmV0aGVybGFuZHMuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R2FsYWN0b21hbm5h

biBkZXRlY3Rpb24gaW4gY29tcHV0ZXJpemVkIHRvbW9ncmFwaHktYmFzZWQgYnJvbmNoby1hbHZl

b2xhciBsYXZhZ2UgZmx1aWQgYW5kIHNlcnVtIGluIGhhZW1hdG9sb2dpY2FsIHBhdGllbnRzIGF0

IHJpc2sgZm9yIGludmFzaXZlIHB1bG1vbmFyeSBhc3BlcmdpbGxvc2lzPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPkJyIEogSGFlbWF0b2w8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkJyaXRp

c2ggam91cm5hbCBvZiBoYWVtYXRvbG9neTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkJyIEogSGFlbWF0b2w8L2Z1bGwtdGl0bGU+PGFiYnItMT5CciBKIEhhZW1h

dG9sPC9hYmJyLTE+PGFiYnItMj5Ccml0aXNoIEpvdXJuYWwgb2YgSGFlbWF0b2xvZ3k8L2FiYnIt

Mj48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJyIEogSGFlbWF0b2w8

L2Z1bGwtdGl0bGU+PGFiYnItMT5CciBKIEhhZW1hdG9sPC9hYmJyLTE+PGFiYnItMj5Ccml0aXNo

IEpvdXJuYWwgb2YgSGFlbWF0b2xvZ3k8L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz40

NDgtNTc8L3BhZ2VzPjx2b2x1bWU+MTIxPC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGVkaXRp

b24+MjAwMy8wNC8yOTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+

PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzL3JhZGlvZ3JhcGh5PC9rZXl3b3JkPjxr

ZXl3b3JkPkJpb2xvZ2ljYWwgTWFya2Vycy9hbmFseXNpcy9ibG9vZDwva2V5d29yZD48a2V5d29y

ZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkLypjaGVtaXN0cnkvbWljcm9iaW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkhlbWF0

b2xvZ2ljIE5lb3BsYXNtcy8qbWljcm9iaW9sb2d5L3JhZGlvZ3JhcGh5PC9rZXl3b3JkPjxrZXl3

b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5MdW5nIERpc2Vhc2VzLCBGdW5nYWwvKmRpYWdu

b3Npcy9yYWRpb2dyYXBoeTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5zLyphbmFseXNpcy9ibG9v

ZDwva2V5d29yZD48a2V5d29yZD5QcmVkaWN0aXZlIFZhbHVlIG9mIFRlc3RzPC9rZXl3b3JkPjxr

ZXl3b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+Umlzazwva2V5d29y

ZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+

VG9tb2dyYXBoeSwgWC1SYXkgQ29tcHV0ZWQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHll

YXI+MjAwMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heTwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh

dGVzPjxpc2JuPjAwMDctMTA0OCAoUHJpbnQpJiN4RDswMDA3LTEwNDggKExpbmtpbmcpPC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjEyNzE2MzY3PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q2xpbmlj

YWwgVHJpYWw8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5u

Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xMjcxNjM2NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZVllYXI9IjEiPjxBdXRob3I+QmVja2VyPC9BdXRob3I+PFll

YXI+MjAwMzwvWWVhcj48UmVjTnVtPjY3ODc3PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMzldPC9E

aXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjY3ODc3PC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZjJweHZ6MmZ4ZHd2cjRlMnBhZnBwZXMxYWV3ZDl2

ZHNlZno1IiB0aW1lc3RhbXA9IjEzOTk3MzA1MDIiPjY3ODc3PC9rZXk+PC9mb3JlaWduLWtleXM+

PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRv

cnM+PGF1dGhvcnM+PGF1dGhvcj5CZWNrZXIsIE0uIEouPC9hdXRob3I+PGF1dGhvcj5MdWd0ZW5i

dXJnLCBFLiBKLjwvYXV0aG9yPjxhdXRob3I+Q29ybmVsaXNzZW4sIEouIEouPC9hdXRob3I+PGF1

dGhvcj5WYW4gRGVyIFNjaGVlLCBDLjwvYXV0aG9yPjxhdXRob3I+SG9vZ3N0ZWRlbiwgSC4gQy48

L2F1dGhvcj48YXV0aG9yPkRlIE1hcmllLCBTLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgTWVkaWNhbCBNaWNyb2Jpb2xvZ3kgYW5k

IEluZmVjdGlvdXMgRGlzZWFzZXMsIEVyYXNtdXMgTWVkaWNhbCBDZW50cmUgUm90dGVyZGFtLCB0

aGUgTmV0aGVybGFuZHMuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R2FsYWN0b21hbm5h

biBkZXRlY3Rpb24gaW4gY29tcHV0ZXJpemVkIHRvbW9ncmFwaHktYmFzZWQgYnJvbmNoby1hbHZl

b2xhciBsYXZhZ2UgZmx1aWQgYW5kIHNlcnVtIGluIGhhZW1hdG9sb2dpY2FsIHBhdGllbnRzIGF0

IHJpc2sgZm9yIGludmFzaXZlIHB1bG1vbmFyeSBhc3BlcmdpbGxvc2lzPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPkJyIEogSGFlbWF0b2w8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkJyaXRp

c2ggam91cm5hbCBvZiBoYWVtYXRvbG9neTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkJyIEogSGFlbWF0b2w8L2Z1bGwtdGl0bGU+PGFiYnItMT5CciBKIEhhZW1h

dG9sPC9hYmJyLTE+PGFiYnItMj5Ccml0aXNoIEpvdXJuYWwgb2YgSGFlbWF0b2xvZ3k8L2FiYnIt

Mj48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJyIEogSGFlbWF0b2w8

L2Z1bGwtdGl0bGU+PGFiYnItMT5CciBKIEhhZW1hdG9sPC9hYmJyLTE+PGFiYnItMj5Ccml0aXNo

IEpvdXJuYWwgb2YgSGFlbWF0b2xvZ3k8L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz40

NDgtNTc8L3BhZ2VzPjx2b2x1bWU+MTIxPC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGVkaXRp

b24+MjAwMy8wNC8yOTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+

PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzL3JhZGlvZ3JhcGh5PC9rZXl3b3JkPjxr

ZXl3b3JkPkJpb2xvZ2ljYWwgTWFya2Vycy9hbmFseXNpcy9ibG9vZDwva2V5d29yZD48a2V5d29y

ZD5Ccm9uY2hvYWx2ZW9sYXIgTGF2YWdlIEZsdWlkLypjaGVtaXN0cnkvbWljcm9iaW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkhlbWF0

b2xvZ2ljIE5lb3BsYXNtcy8qbWljcm9iaW9sb2d5L3JhZGlvZ3JhcGh5PC9rZXl3b3JkPjxrZXl3

b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5MdW5nIERpc2Vhc2VzLCBGdW5nYWwvKmRpYWdu

b3Npcy9yYWRpb2dyYXBoeTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5zLyphbmFseXNpcy9ibG9v

ZDwva2V5d29yZD48a2V5d29yZD5QcmVkaWN0aXZlIFZhbHVlIG9mIFRlc3RzPC9rZXl3b3JkPjxr

ZXl3b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+Umlzazwva2V5d29y

ZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+

VG9tb2dyYXBoeSwgWC1SYXkgQ29tcHV0ZWQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHll

YXI+MjAwMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heTwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh

dGVzPjxpc2JuPjAwMDctMTA0OCAoUHJpbnQpJiN4RDswMDA3LTEwNDggKExpbmtpbmcpPC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjEyNzE2MzY3PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q2xpbmlj

YWwgVHJpYWw8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5u

Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xMjcxNjM2NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [139].CT-scan is more sensitive than chest radiograph to identify lesions of IPA, especially at their early stage PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYXVnZ2FhcmQ8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFy

PjxSZWNOdW0+Mjk4MTMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxNDBdPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjI5ODEzMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9ImYycHh2ejJmeGR3dnI0ZTJwYWZwcGVzMWFld2Q5dmRzZWZ6NSIgdGlt

ZXN0YW1wPSIxNDA5NDcxMzk1Ij4yOTgxMzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUg

bmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9y

cz48YXV0aG9yPkhhdWdnYWFyZCwgQS48L2F1dGhvcj48YXV0aG9yPkVsbGlzLCBNLjwvYXV0aG9y

PjxhdXRob3I+RWtlbHVuZCwgTC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1

dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFJhZGlvbG9neSwgVGF3YW0gSG9zcGl0YWwsIEFsIEFp

biwgQWJ1IERoYWJpLCBVQUUuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWFybHkgY2hl

c3QgcmFkaW9ncmFwaHkgYW5kIENUIGluIHRoZSBkaWFnbm9zaXMsIG1hbmFnZW1lbnQgYW5kIG91

dGNvbWUgb2YgaW52YXNpdmUgcHVsbW9uYXJ5IGFzcGVyZ2lsbG9zaXM8L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+QWN0YSBSYWRpb2w8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFjdGEgcmFk

aW9sb2dpY2EgKFN0b2NraG9sbSwgU3dlZGVuIDogMTk4Nyk8L2FsdC10aXRsZT48L3RpdGxlcz48

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BY3RhIFJhZGlvbDwvZnVsbC10aXRsZT48YWJici0xPkFj

dGEgcmFkaW9sb2dpY2EgKFN0b2NraG9sbSwgU3dlZGVuIDogMTk4Nyk8L2FiYnItMT48L3Blcmlv

ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFjdGEgUmFkaW9sPC9mdWxsLXRpdGxl

PjxhYmJyLTE+QWN0YSByYWRpb2xvZ2ljYSAoU3RvY2tob2xtLCBTd2VkZW4gOiAxOTg3KTwvYWJi

ci0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjI5Mi04PC9wYWdlcz48dm9sdW1lPjQzPC92b2x1

bWU+PG51bWJlcj4zPC9udW1iZXI+PGVkaXRpb24+MjAwMi8wNy8wOTwvZWRpdGlvbj48a2V5d29y

ZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48

a2V5d29yZD5BbXBob3RlcmljaW4gQi9hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2U8L2tleXdv

cmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3NpcywgQWxsZXJnaWMgQnJvbmNob3B1bG1vbmFyeS9kcnVn

IHRoZXJhcHkvKnJhZGlvZ3JhcGh5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48

a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vY29tcHJvbWlzZWQgSG9zdDwv

a2V5d29yZD48a2V5d29yZD5MZXVrZW1pYS9jb21wbGljYXRpb25zL2RydWcgdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5MaXBvc29tZXM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48

a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5OZXV0cm9wZW5pYS9jaGVtaWNh

bGx5IGluZHVjZWQvY29tcGxpY2F0aW9uczwva2V5d29yZD48a2V5d29yZD4qUmFkaW9ncmFwaHks

IFRob3JhY2ljPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29y

ZD48a2V5d29yZD4qVG9tb2dyYXBoeSwgWC1SYXkgQ29tcHV0ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+

VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMjwv

eWVhcj48cHViLWRhdGVzPjxkYXRlPk1heTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2Ju

PjAyODQtMTg1MSAoUHJpbnQpJiN4RDswMjg0LTE4NTE8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTIx

MDAzMjY8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vbmxp

bmVsaWJyYXJ5LndpbGV5LmNvbS9kb2kvMTAuMTAzNC9qLjE2MDAtMDQ1NS4yMDAyLjQzMDMxMC54

L2Fic3RyYWN0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxyZW1vdGUtZGF0YWJhc2UtcHJv

dmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3Vh

Z2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYXVnZ2FhcmQ8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFy

PjxSZWNOdW0+Mjk4MTMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxNDBdPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjI5ODEzMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9ImYycHh2ejJmeGR3dnI0ZTJwYWZwcGVzMWFld2Q5dmRzZWZ6NSIgdGlt

ZXN0YW1wPSIxNDA5NDcxMzk1Ij4yOTgxMzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUg

bmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9y

cz48YXV0aG9yPkhhdWdnYWFyZCwgQS48L2F1dGhvcj48YXV0aG9yPkVsbGlzLCBNLjwvYXV0aG9y

PjxhdXRob3I+RWtlbHVuZCwgTC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1

dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFJhZGlvbG9neSwgVGF3YW0gSG9zcGl0YWwsIEFsIEFp

biwgQWJ1IERoYWJpLCBVQUUuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWFybHkgY2hl

c3QgcmFkaW9ncmFwaHkgYW5kIENUIGluIHRoZSBkaWFnbm9zaXMsIG1hbmFnZW1lbnQgYW5kIG91

dGNvbWUgb2YgaW52YXNpdmUgcHVsbW9uYXJ5IGFzcGVyZ2lsbG9zaXM8L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+QWN0YSBSYWRpb2w8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFjdGEgcmFk

aW9sb2dpY2EgKFN0b2NraG9sbSwgU3dlZGVuIDogMTk4Nyk8L2FsdC10aXRsZT48L3RpdGxlcz48

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BY3RhIFJhZGlvbDwvZnVsbC10aXRsZT48YWJici0xPkFj

dGEgcmFkaW9sb2dpY2EgKFN0b2NraG9sbSwgU3dlZGVuIDogMTk4Nyk8L2FiYnItMT48L3Blcmlv

ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFjdGEgUmFkaW9sPC9mdWxsLXRpdGxl

PjxhYmJyLTE+QWN0YSByYWRpb2xvZ2ljYSAoU3RvY2tob2xtLCBTd2VkZW4gOiAxOTg3KTwvYWJi

ci0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjI5Mi04PC9wYWdlcz48dm9sdW1lPjQzPC92b2x1

bWU+PG51bWJlcj4zPC9udW1iZXI+PGVkaXRpb24+MjAwMi8wNy8wOTwvZWRpdGlvbj48a2V5d29y

ZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48

a2V5d29yZD5BbXBob3RlcmljaW4gQi9hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2U8L2tleXdv

cmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3NpcywgQWxsZXJnaWMgQnJvbmNob3B1bG1vbmFyeS9kcnVn

IHRoZXJhcHkvKnJhZGlvZ3JhcGh5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48

a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vY29tcHJvbWlzZWQgSG9zdDwv

a2V5d29yZD48a2V5d29yZD5MZXVrZW1pYS9jb21wbGljYXRpb25zL2RydWcgdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5MaXBvc29tZXM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48

a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5OZXV0cm9wZW5pYS9jaGVtaWNh

bGx5IGluZHVjZWQvY29tcGxpY2F0aW9uczwva2V5d29yZD48a2V5d29yZD4qUmFkaW9ncmFwaHks

IFRob3JhY2ljPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29y

ZD48a2V5d29yZD4qVG9tb2dyYXBoeSwgWC1SYXkgQ29tcHV0ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+

VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMjwv

eWVhcj48cHViLWRhdGVzPjxkYXRlPk1heTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2Ju

PjAyODQtMTg1MSAoUHJpbnQpJiN4RDswMjg0LTE4NTE8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTIx

MDAzMjY8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vbmxp

bmVsaWJyYXJ5LndpbGV5LmNvbS9kb2kvMTAuMTAzNC9qLjE2MDAtMDQ1NS4yMDAyLjQzMDMxMC54

L2Fic3RyYWN0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxyZW1vdGUtZGF0YWJhc2UtcHJv

dmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3Vh

Z2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA [140], and high resolution computed tomography (HRCT, also called thin-section CT scanning with a thin collimation of 0.25 – 1 mm) is the preferred method. CT angiography may be a useful test pending further evaluation ADDIN EN.CITE <EndNote><Cite><Author>Stanzani</Author><Year>2015</Year><RecNum>507</RecNum><DisplayText>[141]</DisplayText><record><rec-number>507</rec-number><foreign-keys><key app="EN" db-id="25ws99rfnw2zfmert5rxzapsprpa5wr2efdr" timestamp="1432662686">507</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Stanzani, M.</author><author>Sassi, C.</author><author>Lewis, R. E.</author><author>Tolomelli, G.</author><author>Bazzocchi, A.</author><author>Cavo, M.</author><author>Vianelli, N.</author><author>Battista, G.</author></authors></contributors><auth-address>Institute of Hematology &quot;Lorenzo e Ariosto Seragnoli&quot;, Department of Hematology and Oncology.&#xD;Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Division of Radiology.&#xD;Clinic of Infectious Diseases, Department of Internal Medicine Geriatrics and Nephrologic Diseases, S.Orsola-Malpighi Hospital, University of Bologna.&#xD;Diagnostic and Interventional Radiology, &quot;Rizzoli&quot; Institute, Bologna, Italy.</auth-address><titles><title>High resolution computed tomography angiography improves the radiographic diagnosis of invasive mold disease in patients with hematological malignancies</title><secondary-title>Clin Infect Dis</secondary-title><alt-title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</alt-title></titles><periodical><full-title>Clinical Infectious Diseases</full-title><abbr-1>Clin. Infect. Dis.</abbr-1><abbr-2>Clin Infect Dis</abbr-2></periodical><pages>1603-10</pages><volume>60</volume><number>11</number><dates><year>2015</year><pub-dates><date>Jun 1</date></pub-dates></dates><isbn>1537-6591 (Electronic)&#xD;1058-4838 (Linking)</isbn><accession-num>25722200</accession-num><urls><related-urls><url>;[141]. Chest CT-scan performed early after onset of fever helps to identify the cause of fever, may be informative before Aspergillus GM is positive and has been associated with an increased survival in febrile neutropenic patients who have received intensive chemotherapy for a hematologic malignancy PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXNjYTwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+PFJl

Y051bT44MTc8L1JlY051bT48RGlzcGxheVRleHQ+WzE0Mi0xNDRdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjgxNzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1w

PSIxNDU0Mzc0MzQ3Ij44MTc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkJ1c2NhLCBBLjwvYXV0aG9yPjxhdXRob3I+TG9jYXRlbGxpLCBGLjwvYXV0aG9yPjxhdXRob3I+

QmFyYnVpLCBBLjwvYXV0aG9yPjxhdXRob3I+TGltZXJ1dHRpLCBHLjwvYXV0aG9yPjxhdXRob3I+

U2VycmEsIFIuPC9hdXRob3I+PGF1dGhvcj5MaWJlcnR1Y2NpLCBELjwvYXV0aG9yPjxhdXRob3I+

RmFsZGEsIE0uPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+

Qm9uZSBNYXJyb3cgVHJhbnNwbGFudCBVbml0LCBPc3BlZGFsZSBTYW4gR2lvdmFubmkgQmF0dGlz

dGEsIFRvcmlubywgSXRhbHkuIGFidXNjYUBtb2xpbmV0dGUucGllbW9udGUuaXQ8L2F1dGgtYWRk

cmVzcz48dGl0bGVzPjx0aXRsZT5Vc2VmdWxuZXNzIG9mIHNlcXVlbnRpYWwgQXNwZXJnaWxsdXMg

Z2FsYWN0b21hbm5hbiBhbnRpZ2VuIGRldGVjdGlvbiBjb21iaW5lZCB3aXRoIGVhcmx5IHJhZGlv

bG9naWMgZXZhbHVhdGlvbiBmb3IgZGlhZ25vc2lzIG9mIGludmFzaXZlIHB1bG1vbmFyeSBhc3Bl

cmdpbGxvc2lzIGluIHBhdGllbnRzIHVuZGVyZ29pbmcgYWxsb2dlbmVpYyBzdGVtIGNlbGwgdHJh

bnNwbGFudGF0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlRyYW5zcGxhbnQgUHJvYzwvc2Vj

b25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlRyYW5zcGxhbnRh

dGlvbiBQcm9jZWVkaW5nczwvZnVsbC10aXRsZT48YWJici0xPlRyYW5zcGxhbnQuIFByb2MuPC9h

YmJyLTE+PGFiYnItMj5UcmFuc3BsYW50IFByb2M8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2Vz

PjE2MTAtMzwvcGFnZXM+PHZvbHVtZT4zODwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxrZXl3

b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3

b3JkPkFudGlnZW5zLCBGdW5nYWwvKmFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2ls

bG9zaXMvKmRpYWdub3Npcy9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxs

dXMvKmltbXVub2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvbG9naWMgTmVvcGxhc21zLyp0

aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5MdW5nIERp

c2Vhc2VzLypkaWFnbm9zaXMvKm1pY3JvYmlvbG9neTwva2V5d29yZD48a2V5d29yZD5NYW5uYW5z

L2FuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3Jk

Pk5lb3BsYXNtcy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5SZXRyb3NwZWN0aXZlIFN0dWRp

ZXM8L2tleXdvcmQ+PGtleXdvcmQ+KlN0ZW0gQ2VsbCBUcmFuc3BsYW50YXRpb24vYWR2ZXJzZSBl

ZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPlRyYW5zcGxhbnRhdGlvbiwgSG9tb2xvZ291czwva2V5

d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDA2PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuPC9kYXRlPjwvcHViLWRhdGVz

PjwvZGF0ZXM+PGlzYm4+MDA0MS0xMzQ1IChQcmludCkmI3hEOzAwNDEtMTM0NSAoTGlua2luZyk8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTY3OTczNjY8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0

ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTY3OTczNjY8

L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEw

MTYvai50cmFuc3Byb2NlZWQuMjAwNi4wMi4wNzI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPldlaXNzZXI8L0F1dGhvcj48WWVhcj4yMDA1PC9Z

ZWFyPjxSZWNOdW0+Njc2ODY8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjY3Njg2PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZjJweHZ6MmZ4ZHd2cjRl

MnBhZnBwZXMxYWV3ZDl2ZHNlZno1IiB0aW1lc3RhbXA9IjEzOTk3MzA0OTMiPjY3Njg2PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5XZWlzc2VyLCBNLjwvYXV0aG9yPjxh

dXRob3I+UmF1c2NoLCBDLjwvYXV0aG9yPjxhdXRob3I+RHJvbGwsIEEuPC9hdXRob3I+PGF1dGhv

cj5TaW1jb2NrLCBNLjwvYXV0aG9yPjxhdXRob3I+U2VuZGksIFAuPC9hdXRob3I+PGF1dGhvcj5T

dGVmZmVuLCBJLjwvYXV0aG9yPjxhdXRob3I+QnVpdHJhZ28sIEMuPC9hdXRob3I+PGF1dGhvcj5T

b25uZXQsIFMuPC9hdXRob3I+PGF1dGhvcj5HcmF0d29obCwgQS48L2F1dGhvcj48YXV0aG9yPlBh

c3N3ZWcsIEouPC9hdXRob3I+PGF1dGhvcj5GbHVja2lnZXIsIFUuPC9hdXRob3I+PC9hdXRob3Jz

PjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGl2aXNpb24gb2YgSW5mZWN0aW91cyBEaXNl

YXNlcyBhbmQgSG9zcGl0YWwgRXBpZGVtaW9sb2d5LCBVbml2ZXJzaXR5IEhvc3BpdGFsLCBCYXNl

bCwgU3dpdHplcmxhbmQuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R2FsYWN0b21hbm5h

biBkb2VzIG5vdCBwcmVjZWRlIG1ham9yIHNpZ25zIG9uIGEgcHVsbW9uYXJ5IGNvbXB1dGVyaXpl

ZCB0b21vZ3JhcGhpYyBzY2FuIHN1Z2dlc3RpdmUgb2YgaW52YXNpdmUgYXNwZXJnaWxsb3NpcyBp

biBwYXRpZW50cyB3aXRoIGhlbWF0b2xvZ2ljYWwgbWFsaWduYW5jaWVzPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPkNsaW4gSW5mZWN0IERpczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xp

bmljYWwgaW5mZWN0aW91cyBkaXNlYXNlcyA6IGFuIG9mZmljaWFsIHB1YmxpY2F0aW9uIG9mIHRo

ZSBJbmZlY3Rpb3VzIERpc2Vhc2VzIFNvY2lldHkgb2YgQW1lcmljYTwvYWx0LXRpdGxlPjwvdGl0

bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW4gSW5mZWN0IERpczwvZnVsbC10aXRsZT48

YWJici0xPkNsaW4gSW5mZWN0IERpczwvYWJici0xPjxhYmJyLTI+Q2xpbmljYWwgSW5mZWN0aW91

cyBEaXNlYXNlczwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MTE0My05PC9wYWdlcz48dm9s

dW1lPjQxPC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PGVkaXRpb24+MjAwNS8wOS8xNjwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHVs

dDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlnZW5zLCBGdW5n

YWwvYmxvb2Q8L2tleXdvcmQ+PGtleXdvcmQ+QXNwZXJnaWxsb3Npcy8qZGlhZ25vc2lzL2V0aW9s

b2d5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IZW1hdG9sb2dp

YyBOZW9wbGFzbXMvKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3

b3JkPjxrZXl3b3JkPkx1bmcgRGlzZWFzZXMsIEZ1bmdhbC8qZGlhZ25vc2lzL2V0aW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFubmFucy8qYmxvb2Q8L2tl

eXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXVsdGl2YXJpYXRl

IEFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPk9kZHMgUmF0aW88L2tleXdvcmQ+PGtleXdvcmQ+

U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9rZXl3b3JkPjxrZXl3b3JkPlRvbW9ncmFwaHks

IFgtUmF5IENvbXB1dGVkPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDU8L3ll

YXI+PHB1Yi1kYXRlcz48ZGF0ZT5PY3QgMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNi

bj4xNTM3LTY1OTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU4LTQ4MzggKExpbmtpbmcpPC9pc2JuPjxh

Y2Nlc3Npb24tbnVtPjE2MTYzNjMzPC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2gg

U3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzE2MTYzNjMzPC91cmw+

PHVybD5odHRwOi8vY2lkLm94Zm9yZGpvdXJuYWxzLm9yZy9jb250ZW50LzQxLzgvMTE0My5mdWxs

LnBkZjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTA4Ni80NDQ0NjI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xh

bmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkNhaWxsb3Q8L0F1dGhvcj48WWVh

cj4xOTk3PC9ZZWFyPjxSZWNOdW0+NjgyOTM8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjY4

MjkzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZjJweHZ6

MmZ4ZHd2cjRlMnBhZnBwZXMxYWV3ZDl2ZHNlZno1IiB0aW1lc3RhbXA9IjE0MDk0NzMwMDciPjY4

MjkzPC9rZXk+PGtleSBhcHA9IkVOV2ViIiBkYi1pZD0iIj4wPC9rZXk+PC9mb3JlaWduLWtleXM+

PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRv

cnM+PGF1dGhvcnM+PGF1dGhvcj5DYWlsbG90LCBELjwvYXV0aG9yPjxhdXRob3I+Q2FzYXNub3Zh

cywgTy48L2F1dGhvcj48YXV0aG9yPkJlcm5hcmQsIEEuPC9hdXRob3I+PGF1dGhvcj5Db3VhaWxs

aWVyLCBKLiBGLjwvYXV0aG9yPjxhdXRob3I+RHVyYW5kLCBDLjwvYXV0aG9yPjxhdXRob3I+Q3Vp

c2VuaWVyLCBCLjwvYXV0aG9yPjxhdXRob3I+U29sYXJ5LCBFLjwvYXV0aG9yPjxhdXRob3I+UGlh

cmQsIEYuPC9hdXRob3I+PGF1dGhvcj5QZXRyZWxsYSwgVC48L2F1dGhvcj48YXV0aG9yPkJvbm5p

biwgQS48L2F1dGhvcj48YXV0aG9yPkNvdWlsbGF1bHQsIEcuPC9hdXRob3I+PGF1dGhvcj5EdW1h

cywgTS48L2F1dGhvcj48YXV0aG9yPkd1eSwgSC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli

dXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIENsaW5pY2FsIEhlbWF0b2xvZ3ksIENl

bnRyZSBIb3NwaXRhbGllciBSZWdpb25hbCBVbml2ZXJzaXRhaXJlLCBIb3BpdGFsIExlIEJvY2Fn

ZSwgRGlqb24sIEZyYW5jZS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbXByb3ZlZCBt

YW5hZ2VtZW50IG9mIGludmFzaXZlIHB1bG1vbmFyeSBhc3BlcmdpbGxvc2lzIGluIG5ldXRyb3Bl

bmljIHBhdGllbnRzIHVzaW5nIGVhcmx5IHRob3JhY2ljIGNvbXB1dGVkIHRvbW9ncmFwaGljIHNj

YW4gYW5kIHN1cmdlcnk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBDbGluIE9uY29sPC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFsIG9mIGNsaW5pY2FsIG9uY29sb2d5IDogb2Zm

aWNpYWwgam91cm5hbCBvZiB0aGUgQW1lcmljYW4gU29jaWV0eSBvZiBDbGluaWNhbCBPbmNvbG9n

eTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQ2xpbiBPbmNv

bDwvZnVsbC10aXRsZT48YWJici0xPkogQ2xpbiBPbmNvbDwvYWJici0xPjxhYmJyLTI+Sm91cm5h

bCBvZiBDbGluaWNhbCBPbmNvbG9neTwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MTM5LTQ3

PC9wYWdlcz48dm9sdW1lPjE1PC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+PGVkaXRpb24+MTk5

Ny8wMS8wMTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW50aWdlbnMsIEZ1bmdhbC9ibG9v

ZDwva2V5d29yZD48a2V5d29yZD5Bc3BlcmdpbGxvc2lzL2NvbXBsaWNhdGlvbnMvKmRpYWdub3Np

cy9kcnVnPC9rZXl3b3JkPjxrZXl3b3JkPnRoZXJhcHkvaW1tdW5vbG9neS9yYWRpb2dyYXBoeS9z

dXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPkFzcGVyZ2lsbHVzL2lzb2xhdGlvbiAmYW1wOyBwdXJp

ZmljYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+QnJvbmNob2FsdmVvbGFyIExhdmFnZTwva2V5d29y

ZD48a2V5d29yZD5Db21iaW5lZCBNb2RhbGl0eSBUaGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkZl

bWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBEaXNl

YXNlcywgRnVuZ2FsL2NvbXBsaWNhdGlvbnMvKmRpYWdub3Npcy9kcnVnPC9rZXl3b3JkPjxrZXl3

b3JkPnRoZXJhcHkvaW1tdW5vbG9neS9yYWRpb2dyYXBoeS9zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3

b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+

TmV1dHJvcGVuaWEvKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+UHJvZ25vc2lzPC9r

ZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5U

b21vZ3JhcGh5LCBYLVJheSBDb21wdXRlZDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVh

cj4xOTk3PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0

ZXM+PGlzYm4+MDczMi0xODNYIChQcmludCkmI3hEOzA3MzItMTgzWCAoTGlua2luZyk8L2lzYm4+

PGFjY2Vzc2lvbi1udW0+ODk5NjEzNTwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJlc2VhcmNo

IFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11

cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC84OTk2MTM1PC91cmw+

PC9yZWxhdGVkLXVybHM+PC91cmxzPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXNjYTwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+PFJl

Y051bT44MTc8L1JlY051bT48RGlzcGxheVRleHQ+WzE0Mi0xNDRdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjgxNzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjI1d3M5OXJmbncyemZtZXJ0NXJ4emFwc3BycGE1d3IyZWZkciIgdGltZXN0YW1w

PSIxNDU0Mzc0MzQ3Ij44MTc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkJ1c2NhLCBBLjwvYXV0aG9yPjxhdXRob3I+TG9jYXRlbGxpLCBGLjwvYXV0aG9yPjxhdXRob3I+

QmFyYnVpLCBBLjwvYXV0aG9yPjxhdXRob3I+TGltZXJ1dHRpLCBHLjwvYXV0aG9yPjxhdXRob3I+

U2VycmEsIFIuPC9hdXRob3I+PGF1dGhvcj5MaWJlcnR1Y2NpLCBELjwvYXV0aG9yPjxhdXRob3I+

RmFsZGEsIE0uPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+

Qm9uZSBNYXJyb3cgVH