GREENWOOD PUBLIC SCHOOL DISTRICT Genetics FIRST NINE WEEKS ...

GREENWOOD PUBLIC SCHOOL DISTRICT

Genetics

Pacing Guide 2018 ? 2019

FIRST NINE WEEKS--Semester 1

Week

1 2

Instructional Period

Date

Days

Aug. 6

1

Aug. 07 ? 10

4

Aug. 13 ? 17

5

MS CCR Obj.

Academic Focus

2018 MCCR Science Standards Objective Statement

Introduction to Course

Overarching

Science & Engineering Practices (SEPs)

These concepts and skills should be continuously embedded during

instruction, as well as through laboratory experiences,

throughout the course/year.

Added

2010 Objective

Cells Structure

& Function

Classroom Expectations/Syllabus/Overview of Course Requirements/Administer Learning Styles Inventories Overview of Genetics

Plan and conduct controlled scientific investigations to produce data to answer questions, test hypotheses and predictions, and develop explanations or evaluate design solutions, which require the following: Select and use appropriate tools or instruments to collect data,

and represent data in an appropriate form. ADD: safety symbols/procedures & SI measurement. Identify dependent and independent variables and appropriate controls. Analyze and interpret various types of data sets, using appropriate mathematics, in order to verify or refute the hypothesis or determine an optimal design solution. Graphing Construct an explanation of observed relationships between variables. Communicate scientific and/or technical information in various formats. Cite evidence to illustrate how the structure and function of cells are involved in the maintenance of life.

(The Cell Theory, Prokaryotic/Eukaryotic Cells, Cell Organelles, Structure and Function of the Nucleus)

3 Aug. 20 ? 24

Gen. 5.1

Cell

Model the inheritance of chromosomes through meiotic cell

Reproduction division and demonstrate how meiosis and sexual

reproduction lead to genetic variation in populations.

5 GEN. 1a.1

NOTE: (Cell Cycle, Mitosis, and Meiosis, Crossing Over) Model the biochemical structure, either 3-D or computer-

based, of DNA based on the experimental evidence available

to Watson and Crick (Chargaff, 1950; Franklin, 1951).

4 Aug. 27 ? 31

GEN. 1a.2

GEN. 1a.3 GEN. 1a.4

5

GEN. 1a.6

DNA Structure

& Function

Explain the importance of the historical experiments that determined that DNA is the heritable material of the cell (Griffith, 1928; Avery, McCarty & MacLeod, 1944; Hershey & Chase, 1952). Relate the structure of DNA to its specific functions within the cell. Conduct a standard DNA extraction protocol using salt, detergent, and ethanol from various cell types (e.g., plant, animal, fungus).

Compare and contrast the consistency and quantity of DNA extracted from various cell types.

Investigate the structural differences between the genomes (i.e., circular/linear chromosomes and plasmids) found in prokaryotes and eukaryotes.

GEN. 1a.5

Enrichment: Use an engineering design process to refine the

methodology to optimize the DNA-extraction process for

various cell types.*

1st Nine Weeks Continues on the Next Page

GREENWOOD PUBLIC SCHOOL DISTRICT

Genetics

Pacing Guide 2018 ? 2019

Week

FIRST NINE WEEKS--Semester 1

Instructional Period

Date

Days

MS CCR Obj.

GEN. 1b.1

Academic Focus

2018 MCCR Science Standards Objective Statement

Central Dogma Compare and contrast various proposed models of DNA replication (i.e., conservative, semi-conservative, and disruptive).

5 Sept. 4 ? 7 (Sept. 3 Labor Day)

Evaluate the evidence used to determine the mechanism of

4

GEN. 1b. 2

DNA

DNA replication.

Replication Develop and use models to illustrate the mechanics of DNA

replication.

GEN. 1b.3

Microscopically observe and analyze the stages of the cell

cycle (G1-S-G2-M) to describe the phenomenon, and

identify methods at different cell cycle checkpoints through

which the integrity of the DNA code is maintained.

6 Sept. 10 ? 14 7 Sept. 17 ? 21

GEN. 2a.1 Central Dogma Compare and contrast the structure of RNA to DNA and

relate this structure to the different function of each

molecule.

GEN. 2a.2

Describe and model how the process of transcription

produces RNA from a DNA template in both prokaryotes

and eukaryotes.

GEN. 2a.3

Develop a model to show the relationship between the

10

GEN. 2a.4

Transcription

components involved in the mechanics of translation at the ribosome.

Analyze the multiple roles of RNA in translation. Compare

&

the structure and function of tRNA, rRNA, mRNA, and

GEN. 2a.5

snRNA. NOTE: (mRNA Codon Charts)

Translation Enrichment:

Evaluate Beadle and Tatum's "One Gene-One Enzyme

Hypothesis" (1941) in the development of the central dogma

(DNA RNA Protein).

8 Sept. 24 ? 28 9 Oct. 1 ? 5

GEN. 2b.1 GEN. 2b.2

5

GEN. 2b.3 GEN. 2b.4

5

Mutations

Explain how new discoveries, such as alternate splicing of introns, have led to the revision of the central dogma. Identify factors that cause mutations (e.g., environmental, errors in replication, and viral infections). Explain how these mutations may result in changes in protein structure and function. (Gene & Chromosomal) NOTE: (Gene--insertion, deletion, substitution, point, frameshift) NOTE: (Chromosomal--deletion, duplication, inversion translocation; nondisjunction) NOTE: Occurrence and significance of genetic disorders such as sickle cell anemia, Tay-Sachs disorder, cystic fibrosis, Down Syndrome, Klinefelter's, Turner Syndrome, etc. NOTE: (Karyotypes) Describe cellular mechanisms that can help to minimize mutations (e.g., cell cycle checkpoints, DNA polymerase proofreading, and DNA repair enzymes). Investigate the role of mutations and the loss of cell cycle regulation in the development of cancers.

Review 1st Nine Weeks' Exam

GREENWOOD PUBLIC SCHOOL DISTRICT

Genetics

Pacing Guide 2018 ? 2019

SECOND NINE WEEKS--Semester 1

Week

Instructional Period

Date

Days

MS CCR Obj.

1

Oct. 08 ? 09

(Oct. 10-Parent Conf.)

(Oct. 11 ? 12 Fall Break.)

GEN. 4.1

2 Oct. 15 ? 19

12 GEN. 4.2

3 Oct. 22 ? 26

GEN. 4.3

GEN. 4.4

Academic Focus

2018 MCCR Science Standards Objective Statement

Demonstrate Mendel's law of dominance and segregation using mathematics to predict phenotypic and genotypic ratios. NOTE: (Punnett Squares and Monohybrid Crosses)

Mendelian Genetics

Illustrate Mendel's law of independent assortment by analyzing multi-trait cross data sets for patterns and trends. NOTE: (Dihybrid and Trihybrid Crosses, etc.)

Investigate traits that follow non-Mendelian inheritance patterns (e.g., incomplete dominance, codominance, multiple alleles, autosomal linkage, sex-linkage, polygenic, and epistasis) Construct pedigrees from observed phenotypes.

4 Oct. 29 ? Nov. 2

5 Nov. 05 ? 09

6 Nov. 12 ? 16 7 Nov. 26 ? 30 8 Dec. 03 ? 07 9 Dec. 10 ? 14 10 Dec. 17 ? 20

(Dec. 20, 60% Day)

5

Analyze and interpret data to determine patterns of inheritance and disease risk.

GEN. 4.5

Enrichment: Construct maps of genes on a chromosome based on

data obtained from 2-and/or 3-point crosses or from recombination

frequencies.

GEN.3.1

Explain and demonstrate the use of various tools and techniques of

DNA manipulation and their applications in

Forensics (e.g., paternity and victim/suspect identification),

5

Biotechnological

Applications

Agriculture (e.g., pesticide or herbicide resistance, improved yields, and improved nutritional value) Personalized medicine (e.g., targeted therapies, cancer

treatment, production of insulin and human growth hormone,

and engineering insect vectors of human parasites)

GEN.3.2

Experimentally demonstrate genetic transformation, protein

purification, and/or gel electrophoresis.

GEN.5.2

5

GEN.5.3 GEN.5.4

Population Genetics

Explain how natural selection acts upon genetic variability within a population and may lead to changes in allelic frequencies over time and evolutionary changes in populations Describe processes that cause changes in allelic frequencies (e.g., nonrandom mating, small population size, immigration and emigration, genetic drift, and mutation). Apply the Hardy-Weinberg formula to analyze changes in allelic frequencies due to natural selection in a population.

5

GEN.3.3

GEN.3.4

5

GEN.5.5 GEN.5.6

5 GEN.5.7

4

Biotechnological

Applications

Population Genetics

Review

Relate these changes to the environmental fitness of the phenotypes. Enrichment: Use an engineering design process to refine methodology and optimize the process of genetic transformation, protein purification, and/or gel electrophoresis.*

Enrichment: Develop logical arguments based on scientific evidence for and against ethical concerns regarding biotechnology/bioengineering.

Enrichment: Analyze computer simulations of the effects of natural selection on allelic frequencies in a population. Enrichment: Apply the concept of natural selection to analyze differences in human populations (e.g., skin color, lactose persistence, sickle cell anemia, and malaria). Enrichment: Use genomic databases for sequence analysis and apply the information to species comparisons, evolutionary relationships, and/or determine the molecular basis of inherited disorders.

Review Final Exam

GREENWOOD PUBLIC SCHOOL DISTRICT

Genetics

Pacing Guide 2018 ? 2019

THIRD NINE WEEKS--Semester 2

Week

1

2 3

Instructional Period

Date

Days

Jan. 8 ? 11

4

Jan. 15 ? 18

4

(Jan. 14, MLK)

Jan. 21 ? 25

5

MS CCR Obj.

Academic Focus

2018 MCCR Science Standards Objective Statement

Introduction to Course

Overarching

Science & Engineering Practices (SEPs)

These concepts and skills should be continuously embedded during

instruction, as well as through laboratory experiences,

throughout the course/year.

Added

2010 Objective

Cells Structure

& Function

Classroom Expectations/Syllabus/Overview of Course Requirements/Administer Learning Styles Inventories Overview of Genetics Plan and conduct controlled scientific investigations to produce data to answer questions, test hypotheses and predictions, and develop explanations or evaluate design solutions, which require the following: Select and use appropriate tools or instruments to collect data,

and represent data in an appropriate form. ADD: safety symbols/procedures & SI measurement. Identify dependent and independent variables and appropriate controls. Analyze and interpret various types of data sets, using appropriate mathematics, in order to verify or refute the hypothesis or determine an optimal design solution. Graphing Construct an explanation of observed relationships between variables. Communicate scientific and/or technical information in various formats. Cite evidence to illustrate how the structure and function of cells are involved in the maintenance of life.

(The Cell Theory, Prokaryotic/Eukaryotic Cells, Cell Organelles, Structure and Function of the Nucleus)

Gen. 5.1 GEN. 1a.1

Cell Reproduction

Model the inheritance of chromosomes through meiotic cell division and demonstrate how meiosis and sexual reproduction lead to genetic variation in populations. NOTE: (Cell Cycle, Mitosis, and Meiosis, Crossing Over) Model the biochemical structure, either 3-D or computerbased, of DNA based on the experimental evidence available to Watson and Crick (Chargaff, 1950; Franklin, 1951).

GEN. 1a.2

Explain the importance of the historical experiments that

determined that DNA is the heritable material of the cell

(Griffith, 1928; Avery, McCarty & MacLeod, 1944; Hershey

& Chase, 1952).

GEN. 1a.3

DNA

Relate the structure of DNA to its specific functions within

Structure the cell.

GEN. 1a.4

&

Conduct a standard DNA extraction protocol using salt,

4

Jan. 28 ? Feb. 01

5

Function detergent, and ethanol from various cell types (e.g., plant,

animal, fungus).

Compare and contrast the consistency and quantity of DNA extracted from various cell types.

GEN. 1a.6

Investigate the structural differences between the genomes (i.e., circular/linear chromosomes and plasmids) found in prokaryotes and eukaryotes.

GEN. 1a.5

Enrichment: Use an engineering design process to refine the

methodology to optimize the DNA-extraction process for various cell types.*

3rd Nine Weeks Continues on the Next Page

GREENWOOD PUBLIC SCHOOL DISTRICT

Genetics

Pacing Guide 2018 ? 2019

THIRD NINE WEEKS--Semester 2

Week

5

Instructional Period

Date

Days

Feb. 04 ? 08

5

MS CCR Obj.

GEN. 1b.1

GEN. 1b. 2 GEN. 1b.3

Academic Focus

2018 MCCR Science Standards Objective Statement

Central Dogma

DNA Replication

Compare and contrast various proposed models of DNA replication (i.e., conservative, semi-conservative, and disruptive).

Evaluate the evidence used to determine the mechanism of DNA replication. Develop and use models to illustrate the mechanics of DNA replication. Microscopically observe and analyze the stages of the cell cycle (G1-S-G2-M) to describe the phenomenon, and identify methods at different cell cycle checkpoints through which the integrity of the DNA code is maintained.

6 Feb. 11 ? 15 7 Feb. 18 ? 22

GEN. 2a.1 Central Dogma Compare and contrast the structure of RNA to DNA and

relate this structure to the different function of each

molecule.

GEN. 2a.2

Describe and model how the process of transcription

produces RNA from a DNA template in both prokaryotes

and eukaryotes.

GEN. 2a.3

Develop a model to show the relationship between the

10

GEN. 2a.4

Transcription

components involved in the mechanics of translation at the ribosome.

Analyze the multiple roles of RNA in translation. Compare

&

the structure and function of tRNA, rRNA, mRNA, and

GEN. 2a.5

snRNA. NOTE: (mRNA Codon Charts)

Translation Enrichment:

Evaluate Beadle and Tatum's "One Gene-One Enzyme

Hypothesis" (1941) in the development of the central dogma

(DNA RNA Protein).

8 Feb. 25 ? Mar. 1 9 Mar. 4 ? 8

GEN. 2b.1 GEN. 2b.2

5

GEN. 2b.3 GEN. 2b.4

5

Mutations

Explain how new discoveries, such as alternate splicing of introns, have led to the revision of the central dogma. Identify factors that cause mutations (e.g., environmental, errors in replication, and viral infections). Explain how these mutations may result in changes in protein structure and function. (Gene & Chromosomal) NOTE: (Gene--insertion, deletion, substitution, point, frameshift) NOTE: (Chromosomal--deletion, duplication, inversion translocation; nondisjunction) NOTE: Occurrence and significance of genetic disorders such as sickle cell anemia, Tay-Sachs disorder, cystic fibrosis, Down Syndrome, Klinefelter's, Turner Syndrome, etc. NOTE: (Karyotypes) Describe cellular mechanisms that can help to minimize mutations (e.g., cell cycle checkpoints, DNA polymerase proofreading, and DNA repair enzymes). Investigate the role of mutations and the loss of cell cycle regulation in the development of cancers.

Review 3rd Nine Weeks' Exam

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