Statistical Modeling to Quantitate the Central Dogma

[Pages:19]Statistical Modeling to Quantitate the Central Dogma

Jingyi Jessica Li Department of Statistics University of California, Los Angeles May 21, 2018

What is Statistics?

16th-17th Century: Probability Theory (Mathematical Foundations of Statistics)

Jerome Cardan 1501-1576

Blaise Pascal 1623-1662

Pierre de Fermat 1607-1665

From Wikipedia 2

What is Statistics?

19th-20th Century: Emergence and Development of Statistics

Francis Galton 1822-1911

Karl Pearson 1857-1936

Ronald Fisher 1890-1962

From Wikipedia 3

What is Statistics?

21st Century: Computer Age of Statistics

From Google Images 4

The Junction of Statistics and Biology

My Research Overview

From 5

The Junction of Statistics and Biology

Our Team

From 6

"The best thing about being a statistician is that you get to play in everyone's backyard." ? Dr. John W. Tukey

7

The Central Dogma

One of the Most Fundamental Principles of Modern Biological Sciences

[DNA]

transcription

[mRNA]

mRNA degradation

translation

protein degradation

[protein]

8

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