Mental Disorders and Genetics: Bridging the Gap Between ...
Mental Disorders and Genetics: Bridging the Gap Between Research and Society
September 1994
NTIS order #PB95-109690 GPO stock #052-003-01392-4
Foreword
T ethnological advances in genetics drive the search for mental disorder genes. Although the research results have been complicated and, at times, confusing, some important discoveries have emerged. Researchers have located and identified genes associated with A1zheimer's disease. A sound and extensive bank of data provides evidence for the role of genetic factors in schizophrenia and major mood disorders. Other, albeit fewer data lend support to the hypothesis that genetic factors contribute to panic and obsessive-compulsive disorders.
What we know about the genetics of mental disorders, and what we may learn, has implications for research, clinical practice, and society-at-large. A workshop cosponsored by the Office of Technology Assessment and the National Institute of Mental Health focused on these implications. It was prompted by the 1992 report The Biology of Mental Disorders, which was requested by House Committees on Appropriations; Energy and Commerce; Science, Space, and Technology; Veterans Affairs; and the Senate Subcommittee on Science, Technology, and Space of the Committee on Commerce, Science, and Transportation. Senator Edward M. Kennedy, Chairman of the Senate Committee on Labor and Human Resources, also endorsed the 1992 report request. This background paper relays the workshop participants' discussion, augmenting it with other information sources. OTA gratefully acknowledges the assistance of workshop participants as well as other experts who assisted with this work. But as with all OTA products, responsibility for the content is OTA'S alone.
A key focus of the workshop was the impact of genetic research on people with mental disorders and their family members. Workshop testimony made clear that they want to know the latest research discoveries. They are encouraged by research progress and the possibility of improved treatment. They worry about the genetic risk for a serious mental disorder that their family members face. They want to be more equal partners in research. They welcome the de-stigmatizing influence of biomedical research. Yet they fear its potential abuse. However, as the background paper title suggests, a gap separates research-derived information on genetics and mental illness from the people who desire it. This background paper offers one resource in closing this gap.
ROGER C. HERDMAN Director
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Preject Staff
Clyde J. Behney Assistant Director, OTA
Sean R. Tunis Health Program Director
ADMINISTRATIVE STAFF Beckie Erickson Office Administrator
Carolyn Martin Word Processing Specialist
Daniel B. Carson PC Specialist
Carolyn Swarm PC Specialist
LAURA LEE HALL Project Director
Jacqueline T. Keller Research Analyst
Arna M. Lane Editor
PUBLISHING STAFF Mary Lou Higgs Manager, Publishing Services
Denise Felix Production Editor
Dorinda Edmondson Electronic Publishing Specialist
Susan Hoffmeyer Graphic Designer
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1 Introduction 1
Emergent Workshop Themes 6 Chapter 1 References 7
2 Research Results 9
Genetic Research Primer 10 Alzheimer's Disease 12 Schizophrenia 14 Major Mood Disorders 17 Panic Disorder 19 Obsessive-Compulsive Disorder 20 Summary and Conclusions 21 Chapter preferences 24
3 implications for Society 29
Ethics and Research 30 Genetic Counseling 36 Public Perceptions and Social Implications 44 Summary and Conclusions 49 Chapter preferences 50
APPENDIXES
A Workshop Participants 55
B Acknowledgments 57
c ontents
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