PDF Anterior horn cell disease Dr manesh pillay Neurology ...
? Anterior horn cell disease
? Dr manesh pillay ? Neurology department ? University of pretoria ? February 2012
Anterior horn cell disease
Motor neuron pathology. ? Vulnerable to defects in excitotoxicity,
RNA transport and splicing,axonal protein transport, mitochondrial function,protein misfolding and oxidative stress. ? Sporadic, late onset, degenerative - motor neuron disease (MND) = amyotrophic lateral sclerosis (ALS) ? Untreatable and fatal.
Neuroanatomy
? Lower motor neurons in brainstem and spinal cord
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