RESEARCH Open Access Increased left ventricular torsion in …

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R?ssel et al. Journal of Cardiovascular Magnetic Resonance 2011, 13:3

RESEARCH

Open Access

Increased left ventricular torsion in hypertrophic cardiomyopathy mutation carriers with normal wall thickness

Iris K R?ssel1*, Wessel P Brouwer3,6, Tjeerd Germans3,6, Paul Knaapen3, J Tim Marcus4, Jolanda van der Velden5, Marco JW G?tte2, Albert C van Rossum3

Abstract

Background: Increased left ventricular (LV) torsion has been observed in patients with manifest familial hypertrophic cardiomyopathy (HCM), and is thought to be caused by subendocardial dysfunction. We hypothesize that increased LV torsion is already present in healthy mutation carriers with normal wall thickness.

Methods: Seventeen carriers with an LV wall thickness ................
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