Significance of Left Ventricular Outflow Obstruction on ...

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SPECTRUM AND CLINICAL SIGNIFICANCE OF SYSTOLIC FUNCTION AND MYOCARDIAL FIBROSIS ASSESSED BY CARDIOVASCULAR MAGNETIC RESONANCE IN HYPERTROPHIC CARDIOMYOPATHY

Iacopo Olivotto MD1, Barry J. Maron MD2, Evan Appelbaum MD3,4, Caitlin J. Harrigan4,

Carol Salton3,4 C. Michael Gibson3,4, James E. Udelson MD5, Christopher O’Donnell6,

John R. Lesser MD2, Warren J. Manning MD3,4 and Martin S. Maron MD5

1Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Universitaria Careggi, Florence Italy; 2Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota; 3Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, Massachusetts; 4PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, Massachusetts; 5Division of Cardiology, Tufts Medical Center, Boston, Massachusetts; 6National Heart, Lung and Blood Institute of the Framingham Heart Center, Framingham, Massachusetts.

Running Head: CMR and LV systolic function in HC

Total word count: 4,380 (including references and Tables)

Address for correspondence: Dr. Iacopo Olivotto

Dipartimento Cuore e Vasi

Azienda Ospedaliera Universitaria Careggi

Viale Pieraccini 19, 50134 Firenze, Italy

Tel/Fax: 39 055 7949335

Email: olivottoi@aou-careggi.toscana.it

Disclosures

There are no potential conflicts of interest to disclose.

1 ABSTRACT

Background. In hypertrophic cardiomyopathy (HC) the clinical significance attributable to the broad range in left ventricular (LV) systolic function, assessed as ejection fraction (EF), is incompletely resolved. Objective. To evaluate EF by cardiovascular magnetic resonance (CMR) in a large cohort of HC patients with respect to clinical status and evidence of left ventricular remodelling with late gadolinium enhancement (LGE). Methods. CMR was performed in 310 consecutive patients, age 42±17 years. Results. EF in HC patients was 71±10% (range 28-89%), exceeding that of 606 healthy controls without cardiovascular disease (66±5%, p ................
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