PDF Division of Intramural Research NAEHS Council Update - June 4 ...

Division of Intramural Research NAEHS Council Update June 2019

DIR RECRUITMENT

Metabolomics Lead The Division of Intramural Research of the National Institute of Environmental Health Sciences (NIEHS) is recruiting a Staff Scientist to function as the Metabolomics Lead within the Mass Spectrometry Research and Support Group. We are seeking an experienced scientist with a proven track record to increase the capabilities and capacity of metabolomic studies at NIEHS. The Metabolomics Lead will develop and implement innovative mass spectrometry-based metabolomic analytical methods to support the research needs of NIEHS investigators. The ideal candidate will also have extensive experience developing pipelines for analysis, visualization and interpretation of complex omics data and will work closely with members of the Integrative Bioinformatics Support Group. Dr. Xiaoling Li, Senior Investigator in the Signal Transduction Laboratory is the Chair of the Search Committee.

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NEW APPOINTMENTS IN DIR

New Tenure-Track Investigators

Dr. Joseph Rodriguez, Ph.D., started as a Tenure-Track Investigator in the Epigenetic and Stem Cell Biology Laboratory and member of the NIH Distinguished Scholars Program. He was previously a Postdoctoral Fellow in the Laboratory of Receptor Biology and Gene Expression at NCI. Dr. Rodriguez is initiating an independent research program at NIEHS focused on developing novel single-cell biophysical methods to study dynamic action of Estrogen Receptors and other transcription factors in living cells.

Dr. Marcos Morgan from the MRC Centre for Regenerative Medicine, University of Edinburgh, UK, and the European Bioinformatics Institute, has accepted a position to join the Reproductive and Developmental Biology Laboratory as an Earl Stadtman Tenure-Track Investigator. Dr. Morgan will initiate a research program at NIEHS focused on the role of RNA modifications such as uridylation and cytidylation in regulating male fertility. He is expected to start in June 2019.

Dr. Benedict Anchang, Ph.D. from the Department of Radiology at Stanford University has accepted a position as an Earl Stadtman Tenure-Track Investigator in the Biostatistics and Computational Biology Branch with a joint appointment in the NCI Center for Cancer Research. He was also selected as a member of the NIH Distinguished Scholars Program. Dr. Anchang will initiate an independent research program at NIEHS focused on developing and applying novel and innovative computational models to better understand physiology, tumor progression and responses to environmental exposures using high-dimensional singlecell data. Dr. Anchang is scheduled to start in the August 2019.

Dr. Elizabeta Gjoneska from the Picower Institute for Learning and Memory at MIT has accepted an offer to join the Neurobiology Laboratory as a Tenure-Track Investigator. Dr. Gjoneska will initiate an independent research program focused on dissecting mechanisms underlying microglial dysfunction during neurodegeneration. She is expected to start at NIEHS in September 2019.

SCIENTIFIC UPDATE BY A DIR PRINCIPAL INVESTIGATOR CELL LINE MODELS OF CYTOTOXIC RESPONSE - INTEGRATION OF STATISTICAL

METHODS DEVELOPMENT AND GENETIC ASSOCIATION MAPPING ALISON MOTSINGER-REIF, PH.D., CHIEF

BIOSTATISTICS AND COMPUTATIONAL BIOLOGY BRANCH DIR, NIEHS

The investigation and discovery of genetic factors that determine differential drug response is the fundamental goals of pharmacogenomics. Lymphoblastoid cell lines (LCLs) have become a well-established model for understanding dose response, including exploring the genetic etiology of such drug response. Here We present the results of genome-wide association mapping studies (GWAS) for a large number of commonly used anti-cancer drugs, along with the methods development studies behind the high throughput mapping. This GWAS screen produced interesting potential candidate genes, and we present initial results of functional/clinical followup of these candidates. We will also present the initial results of clinical validation results from top candidates. Additionally, we present topical challenges and new directions related to drug combinations. These results demonstrate an integrated approach to bioinformatics methods development and application.

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TRAINING AND MENTORING

2019 NIEHS Biomedical Career Symposium The Twenty Second Annual NIEHS Biomedical Career Symposium was held on Friday April 26, 2019 at the Environmental Protection Agency Campus, Research Triangle Park, NC. The keynote address entitled "Reimagining Fit: Moving Toward Personal and Professional Congruence" was delivered by Stephanie Eberle, M.Ed., Assistant Dean of the BioSci Careers Program at Stanford University. Areas covered in the Symposium included: Career Specific Discussion; Career Development Workshops; Networking Opportunities; and One-on-One CV/Resume/LinkedIn Consultations with professionals from academia, industry and government.

There were more than 300 registered attendees from universities and research institutions in the Triangle Area and across North Carolina. This event was cosponsored by the NIEHS Office of Scientific Director, NIEHS Trainees Assembly and the Environmental Protection Agency.

Keynote & Workshop Speakers ? Tammy Collins, Ph.D., Director, Office of Fellows' Career Development, NIEHS, NIH ? Lori Conlan, Ph.D., Director, Office of Postdoctoral Services, OITE, NIH ? Angela Davis, Human Resources Specialist, NIEHS, NIH ? Stephanie Eberle, M.Ed., Assistant Dean of the BioSci Careers, Stanford University ? Irina Filonova, Ph.D., Academic Developer, Okinawa Institute of Science and Technology ? Erin Haynes, Ph.D., Professor and Chair, Department of Epidemiology, University of Kentucky College of Public Health ? Denise Saunders, Ph.D., N.C.C., Career Counselor and Consultant, National Institutes of Health, Office of Intramural Training and Education ? Stacy Schnieber, M.H.R., VP of People and Culture, Camargo Pharmaceutical Services LLC ? Dara Wilson-Grant , M.S.Ed., L.P.C.A., Associate Director of Postdoctoral Affairs at UNC-Chapel Hill and owner of Careers in Bloom, UNC-Chapel Hill and Careers in Bloom ? Sharon Milgram, Ph.D., Director, Office of Intramural Training and Education, OITE, NIH ? Denise Saunders, Ph.D., N.C.C., Career Counselor and Consultant, NIH Office of Intramural Training and Education ? Stacy Schnieber, M.A., P.H.R., Vice President of People and Culture, Camargo Pharmaceutical Services ? Antony Williams, Ph.D., Cheminformatician, EPA ? Paula Stephan, Ph.D., Professor of Economics, Research Associate, Georgia State University, National Bureau of Economic Research ? Dara Wilson-Grant, M.S.Ed., N.C.C., L.P.C.A., Associate Director/Career Counselor, Office of Postdoctoral Affairs; Owner, Consultant, Careers in Bloom, University of North Carolina

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