Blocking dopamine receptors
Dopamine Antagonists - Alcohol Rehab
1. Traditional: block dopamine receptors. 2. Atypical: block serotonin receptors (has less extrapyramidal effects) MOA: 1. Dopamine receptor blocking activity in brain. D1, D5. activate adenylyl cyclase. D2, D3, D4. inhibit adenylyl cyclase (D2. correlates to efficacy of neuroleptic) 2. Serotonin receptor blocking activity in brain. S2
[DOC File]Wednesday, November 29, 2000
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Dopamine hypothesis - suggests that schizophrenia results from EXCESSIVE dopamine. activity in certain brain areas. Drugs that reduce positive symptoms do so by "blocking" these receptors. This is overly simplistic. Actually, the drugs reduce dopamine. activity to abnormally low levels.
[DOC File]Chapter 14 Schizophrenias and Other Psychotic Disorders
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acts centrally by blocking dopamine receptors in the CTZ and peripherally by increasing gastric contraction, speeds gastric empting and strengthens cardiac shincter tone. Indicated as antiemetic in paroviral eneritis, uremic vomiting and vomiting associated with chemotherapy. Also used for tretment of gastric motility disorders. Antihistamines:
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Blocking Dopamine receptors. Biological researchers believe that dopamine plays an important part in the origins of schizophrenia. An important goal of antipsychotic drug therapy, then, is to reduce the amount of available dopamine or to reduce the number of dopamine receptor sites by blocking them.
Houston Community College
Blocks dopamine receptors in the mesolimbic-mesocortical system while having less dopamine D2 receptor blocking activity in the extrapyramidal system. It is an effective antipsychotic agent which produces minimal extrampyramidal side effects, including an apparent lack of tardive dyskinesia
[DOC File]Management of Hyperprolactinemia in Patients Receiving ...
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to dopamine in the brain. d. Excessive brain levels of dopamine are sometimes involved in. the hallucinations and perceptual distortions that characterize. schizophrenia. Some antipsychotic drugs work by blocking. dopamine receptors and reducing dopamine activity in the brain. e. Serotonin is involved in sleep, moods, and emotional states,
[DOC File]Pharmacology Study Guide – Test 2
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High doses: vasoconstriction through a1-receptors. (2)Renal and visceral: Dopamine dilates renal and splanchnic arterioles by activating dopaminergic receptors, thus increasing blood flow to the kidneys and other viscera (see Figure 6.12). These receptors are not affected by α or β-blocking drugs. Therefore, dopamine is clinically useful in ...
[DOC File]Drugs used in Gastrointestinal system disorders
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Neuroleptic agent: a drug that prevents nausea/vomiting by blocking dopamine receptors in CTZ & may also block Ach; i.e. Thorazine, Compazine, Phenergan, Reglan. Anticholinergics: work by binding to and blocking ACH receptors on vestibular nuclei (labyrinth) Tx of motion sickness: Scopalamine
[DOC File]Biological explanations of schizophrenia
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Antipsychotic medications cause hyperprolactinemia by blocking D2 dopamine receptors and therefore dopamine action. Because dopamine tonically inhibits prolactin release from the pituitary gland, medications which decrease dopaminergic tone result in elevations of prolactin. Hyperprolactinemia itself has not been demonstrated to directly result ...
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