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[DOC File]OECD GUIDELINE FOR THE TESTING OF CHEMICALS
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Bone marrow (and/or fresh aspirate) Brain (including sections of cerebrum, cerebellum, and medulla/pons) [Eyes and eyelids (including retina)] Heart . Kidneys. Larynx (3 levels, 1 level to include the base of the . epiglottis) Liver. Lung (all lobes at one level, including main bronchi) Lymph nodes, draining upper (cervical/

[DOC File]VISN 22 Drug Monograph Template
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2. unable to aspirate bone marrow. 3. proliferative CMML. 4. ANC3X ULN, D.Bili >2.0. 5. Prior ≥grade 3 toxicity to thalidomide. 6. nutritional anemias. 7. epoetin use within 7 days. 8. chronic >physiologic doses of steroids. Lenalidomide 10mg daily for 21 days , repeat every 28 days (N=45) Amended to:

[DOC File]What is the most approriate endpoint for a phase III ...
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Bone marrow aspirate and trephine. MCV of family members. A 64 year old man who is taking long term prednisone has a FBC and is found to have a HB of 94. MCV is 90. Iron studies given show low iron, low transferrin, ferritin 200, ESR 45. What is the most likely explanation for his anaemia? Iron deficiency. Iron deficiency and chronic disease

[DOCX File]AusPAR Attachment 2: Extract from the Clinical Evaluation ...
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bone marrow aspirate. BMB. bone marrow biopsy. BPI-SF. Brief Pain Inventory–Short Form. CBC. ... The ixazomib concentration in Period 2 might have been confounded due to an ixazomib carry over effect from Period 1 due to an inadequate wash-out between the two periods resulting from the long terminal half-life of the drug.

[DOCX File]Guide: Investigational medicinal product dossier for ATMP
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is the material procured or generated that will ultimately provide one of the key functional components within the drug substance. For example, blood, biopsy or- bone marrow aspirate. Both vector and the bone marrow aspirate for CAR-T gene therapy act as starting materials (see also 2001/83/EC, Part IV, Advanced therapy medicinal products).

[DOC File]TEST
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BONE CULTURE No growth in 5 days MICRO Send in sterile container. Room temp. Room temp. Daily 13 BONE MARROW ASPIRATION Report and interpretation provided HEM 2-3 ml Heparinized Bone Marrow Aspirate, plus 5 ml blood (lavender top tube for CBC5D and Retic Count). Store at Room temperature. Must be received by the laboratory as soon as possible.

[DOC File]White Blood Cell pathology
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In the bone marrow aspirate there are no signs of neoplastic lymphoid infiltration, but the signs of increased non effective erythropoeisis are found. 1. Colour index: Hb x 3 divide by 3 first number in erythrocyte count. 50x3/150= 1 (normal is 0.85-1.05) 2. Diagnosis: anemia,aplastic myelotoxic agranulocytosis. Reticulocyte are absent- aplastic

[DOC File]AAOS SYMPOSIUM - Orthopaedic Trauma Association (OTA)
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Bone marrow aspirate has a high concentration of CTPs. One milliliter of iliac aspirate contains approximately 40 million nucleated cells 1500 of which are CTPs..Clinical use with concentration and implantation for Fx and nonunions. Human data is limited, only case reports treating a limited number of patients demonstrating successful treatment ...

[DOC File]ROTATION GUIDELINES - Morgan State University
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Assist in the proper preparation, staining, and review of bone marrow aspirate. ... Observe the digestion and concentration procedure on culture specimens for mycobacteriae, if performed in lab. 10. State the optimal growth requirements (temperature and atmosphere) for M.

[DOC File]Low density Bone Marrow Harvest
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Low Density Bone Marrow Harvest. Remove hind legs of mouse at hip bone?), scrap away muscle, and place in PBS. Crush bones in a mortar and pestle under hood . Filter through a 70um cell strainer Into a conical tube. Wash bones one more time by adding 10 mls of 1X PBS, filter , and add to previously filtered cells. Spin at 1200 rpm for 5minutes

[DOC File]ANAEMIA - University of the West Indies
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Bone marrow examination. Cytology prepared from bone marrow aspirate. Cellularity and infiltration assessed from bone marrow biopsy ... lack of mental concentration, drowsiness, restlessness and muscular weakness are common symptoms of severe anaemia. Some of these signs may be manifestations of cerebral hypoxia. Paresthesias and neurological ...

[DOC File]National PBM Monograph Template Rev20091005
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Bone marrow aspirate and biopsy were required at baseline and within 2 weeks of documented response . ... The median time to maximum concentration occurred immediately after infusion for the antibody-drug conjugate and 2-3 days after the infusion for MMAE.

[DOC File]Aastrom Biosciences, Inc
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The Base Medium is a sterile and endotoxin free growth medium used in the processing of the bone marrow aspirate. The Base Medium is used from the start of the manufacturing process through to the harvest of the cellular product from the Cell Cassette.

Bone marrow aspirate concentration