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Detection of Clinically Significant Prostate Cancer: Short Dual–Puls…
of a clinically significant level of activity. Because various tumor types have different prognostic factors, eligibility requirements, and patterns of responsiveness to a particular drug or combination of drugs or therapy, Phase 2 trials are conducted in homogenous clinical entities (e.g. metastatic breast cancer patients with measurable ...
clinically insignificant prostate cancer

[DOC File]Molecular Oncology Testing for Cancer Diagnosis, Prognosis ...
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At screening, any clinically significant abnormality should be recorded as a preexisting condition. At the end of the study, any new clinically significant findings/abnormalities that meet the definition of an adverse event must also be recorded and documented as an adverse event.
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[DOCX File]CAP Cancer Protocol Penis
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Figure S5: Intratumoral expression of immune pathway and cell-type score with BEMPEG plus NIVO. Gene analysis using the NanoString nSolver platform was performed pre- and on-treatment (week 3) for all patients with available tumor samples (19 baseline and 9 on-treatment tumor biopsies) to assess the effect of BEMPEG plus NIVO on selected immune pathways (A) and cell types (B).
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[DOC File]UNIVERSITY OF NEBRASKA MEDICAL CENTER
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The string of characters used to identify the five-digit zone improvement plan (ZIP) code and the four-digit extension code (if available) that represents the geographic segment that is a subunit of the ZIP code, assigned by the U.S. Postal Service to a geographic location to facilitate mail delivery; or the postal zone specific to the country, other than the U.S., where the mail is delivered
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[DOCX File]Wisconsin Department of Public Instruction
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Lam VK, Tran HT, Banks KC, et al. Targeted tissue and cell-free tumor DNA sequencing of advanced lung squamous-cell carcinoma reveals clinically significant prevalence of actionable alterations. Clin Lung Cancer. 2019 Jan;20(1):30-36.e3.
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[DOCX File]Supplemental Figures - Home | Cancer Discovery
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We hypothesize that clinically significant radiation toxicity can be predicted with circulating biomarkers as miRNA or with genetic polymorphisms. 2.0 OBJECTIVES. 2.1 Primary Objectives. To determine if IMRT reduces acute gastrointestinal toxicity in the 5th week (after 23-25 fractions) of pelvic radiation as measured with EPIC.
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[DOC File]RADIATION THERAPY ONCOLOGY GROUP - MD Anderson …
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Rosiglitazone, a CYP2C8 substrate, was given with vismodegib at steady state with no clinically significant change in rosiglitazone exposure, suggesting that there is no clinically significant inhibition of CYP2C8 by vismodegib. Vismodegib was also found in vitro to be a substrate of the efflux p-glycoprotein transporter.
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[DOCX File]Supplemental methods - Clinical Cancer Research
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The protocol recommends the use of the TNM staging system of the American Joint Committee on Cancer (AJCC) for carcinoma of the penis.34 By AJCC convention, the designation T refers to a primary tumor that has not been previously treated.
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[DOCX File]DCP, Standard Operating Procedure, Reviewing and …
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See definition of direct services above. 1G. ... Cancer (Leukemia, tumors, and other forms of cancer) See definition above. 3S. Cardiovascular (Clinically significant cardiac murmurs, cardiac insufficiency, arrhythmias, pace makers, hypertension, Kawasaki’s disease, Raynaud’s syndrome)
clinically insignificant prostate cancer

[DOC File]Clinical Research Protocol - Duke University
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A DLT was defined as any one of the following occurring during the first cycle (21 days) in Part 1: all TGs: any grade 3/4 non-hematological-related event, excluding AEs with clear alternative explanations (due to underlying disease or disease progression) or transient laboratory values without associated clinically significant signs or ...
clinically significant evidence definition

Clinically significant cancer definition