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      GAO (2011) shows that retail price of 100 commonly used prescription medications increased at an average annual rate of 6.6 percent from 2006 to 2010. The annual price rise is particularly high in brand-name drugs (8.3%) as compared to generic drugs (-2.6%). The pain of high price is real and substantial: According to the Commonwealth Fund, 48 ...

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      Ng[322] Case report Patient with severe secondary PH + RV dysfunction Oral sildenafil added to NO None Reduced mPAP, PVR maintained; allowed weaning of CVS …

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      Topical Sildenafil has already been evaluated in a phase 1 (n=21) and phase 2b study (n=31), which demonstrated that it was well tolerated and resulted in increased blood flow to the vaginal tissue in both pre- and post-menopausal women. IP includes six issued U.S. patents related to topical delivery. Given sildenafil’s (i.e. Viagra’s) known safety profile, a 505(b)(2) FDA NDA pathway may ...

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