Molecular therapy and clinical development
[DOC File]Molecular Oncology Testing for Cancer Diagnosis, Prognosis ...
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Molecular risk classification by gene expression profiling has clinical impact and influences physicians to direct clinical management of CM patients. The vast majority of the changes implemented after the receipt of test results were reflective of the low or high recurrence risk associated with the patient's molecular classification.
[DOCX File]NCI at Frederick: NCI at Frederick Home Page
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A growing body of evidence demonstrates that SnCs can promote tumor growth, relapse, metastasis, and resistance to therapy, in part via secretion of a plethora of inflammatory mediators (e.g., cytokines and chemokines), growth factors, and extracellular proteases – termed the senescence-associated secretory phenotype (SASP).
[DOCX File]NCI MATCH Clinical Trial Partipation Agreement
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NCI-MATCH is a clinical trial that will enroll patients with solid tumors or lymphomas who have progressed on standard therapy. This study aims to establish whether patients with tumor mutations/amplifications in one of the genetic pathways of interest (defined in the protocol), are more likely to derive clinical benefit as defined by objective response or progression-free survival if treated ...
[DOCX File]Competitive LOI - Cancer Therapy Evaluation Program (CTEP)
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Apr 07, 2014 · CTEP clinical research has a strong focus on molecularly-driven studies that incorporate suitable biomarkers. Because of the complexity of this research, it is necessary to assemble individuals with different kinds of expertise and resources in order to perform the clinical …
[DOC File]Title: From Epilepsy to Ecstasy: The Biological Basis of ...
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Credit: This is a 4-unit course that includes lectures, clinical correlations, and case-based learning situations led by both the instructor and students. Purpose: The recent explosion of research in the field of neuroscience has produced an increasingly thorough understanding, at multiple levels of description from the molecular to the ...
[DOC File]NCI Experimental Therapeutics (NExT)
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Replace text with requested information. Include a statement about how the proposed agent or therapy differs from standard therapies in practice or under clinical evaluation. If available, provide comparator efficacy and safety data for your investigational agent (biologic, vaccine, or new molecular entity) or cell therapy approach.
Genetic and Molecular Basis of Diabetic Foot Ulcers
Genetic and molecular basis of diabetic foot ulcers: clinical review. Shaurya Jhamb, Venkat. N. Vangaveti, Usman. H. Malabu. Translational Research on Endocrinology and Diabetes [TREAD], College ...
[DOC File]METALS IN MEDICINE MEETING REPORT
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The frequencies of success in screens and also of failure in clinical development are not different than the experience with development of non-metal containing agents. The model for drug development within the NCI program has changed to focus on mechanism-oriented rational drug discovery based on known molecular targets.
[DOC File]NCI Experimental Therapeutics (NExT)
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For clinical drug development projects (Phase 0/I/II), ... If available, provide comparator efficacy and safety data for your investigational agent (biologic, vaccine, or new molecular entity) or cell therapy approach. Address the novelty of the concept with respect to the target and approach and indicate the likelihood of the concept advancing ...
[DOCX File]SBIR/STTR Program Descriptions and Research Topics
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Development and validation of human aging mechanistic markers predictive for various age-related conditions or responses to interventions. Products of interest include the development and validation of commercial assays which could be used in clinical/epidemiologic research to assess mechanisms of aging (e.g., cell senescence, autophagy, DNA damage and repair) in human blood, tissues or cells ...
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