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[DOCX File]Attachment: Product Information: Avanafil
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Tadalafil is a reversible inhibitor of cyclic guanosine monophosphate (cGMP) – specific phosphodiesterase type 5 (PDE5) in the smooth muscle of the corpus cavernosum, the prostate, the bladder and their vascular supply.
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Avanafil
What is the diagnosis documented in the patient’s chart that requires treatment with a phosphodiesterase type 5 (PDE-5) inhibitor? Are you currently board-certified in pulmonary or cardiovascular disease, or is there documentation in the patient’s medical record of an evaluation by a physician board-certified in pulmonary or cardiovascular ...
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[DOC File]Pharmacotherapy of _Erectile Dysfunction_______________
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Medicines used in the treatment of PAH were first listed on the PBS in 2004. Between July 2013 and 2016, PBS listed medicines fell into three classes: endothelin receptor antagonists (ERAs), synthetic prostacyclin / prostacyclin analogues, and phosphodiesterase type-5 (PDE5) inhibitors.
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[DOC File]For the Confused
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Oral phosphodiesterase type 5 inhibitors, unless contraindicated, should be offered as a first-line of therapy for erectile dysfunction. For patients with psychogenic erectile dysfunction, psychotherapy may be used as monotherapy, or as an adjunct to specific treatments for the disorder.
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[DOCX File]Abbreviations - PBS
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PDE5 inhibitors stop the degradation of cGMP-specific phosphodiesterase type 5 (PDE5), thereby enhancing the vasodilatory effects of nitric oxide. PDE5 inhibitors have been shown to have a favorable effect on increasing exercise capacity and decreasing PAP in PAH clinical studies.
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[DOCX File]AusPAR Attachment 1: Product Information for Cialis ...
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Sildenafil and tadalafil are phosphodiesterase type 5 (PDE5) inhibitors. A PDE-5 inhibitor works by opening the blood vessels in the lungs to allow blood to flow through more easily. The advent of PDE5 inhibitors for PAH treatment introduced a second class of oral agents in addition to ERAs, but with comparatively fewer toxicity issues.
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[DOC File]Pulmonary Hypertension - developinganaesthesia
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4.2.3 Therapies targeting NO pathway: phosphodiesterase (PDE) type 5 inhibitors When compared with expression of PDE-5 in other tissues such as the penile corpus cavernosum and the myocardium, the expression and activity of PDE-5 is considerably higher in lung and in pulmonary vascular smooth muscle cells (Corbin, Beasley et al. 2005).
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[DOC File]Targeted therapies in Pulmonary arterial Hypertension (PAH)
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When treating erectile dysfunction, treatment with a PDE5 (phosphodiesterase type 5) inhibitor may be considered in patients who had an MI more than 6 months earlier and who are now stable. PDE5 inhibitors must be avoided in patients treated with nitrates and/or nicorandil because this can lead to dangerously low blood pressure.
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[DOCX File]List of Tables
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Phosphodiesterase type 5 (PDE5) inhibitors. These drugs may only be prescribed through Section 100 of the Pharmaceutical Benefits Scheme (PBS) if specific criteria are met, and only through designated prescribing centres. These agents are prescribed by specialist cardiologists or respiratory physicians.
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[DOCX File]NY PDP Fax Worksheet – PDE-5 Inhibitors
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Avanafil is a reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). When sexual stimulation causes the local release of nitric oxide, inhibition of PDE5 by avanafil produces increased levels of cGMP in the corpus cavernosum of the penis.
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Phosphodiesterase type 5 pde5 inhibitors