The fxr1 protein must inhibit translati of the mrnas the fxr1 protein must deg
[PDF File]Stat1 stimulates cap-independent mRNA translation to ...
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and B-cell lymphoma xl. Translation of the select mRNAs requires the transcriptional function of Stat1, resulting in the up-regulation of the p110γ subunit of phosphoinositide 3-kinase (PI3K) class IB and increased expression of the translational repressor translation initiation factor 4E (eIF4E)-binding protein 1 (4EBP1). Increased
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iii Abstract Recent data indicate that the various steps in post-transcriptional gene expression are linked. In the studies presented in this thesis, we show further evidence of t
[PDF File]FXR1 Is an IL-19-Responsive RNA-Binding Protein that ...
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The regulation of mRNA stability and translation are two levels of post-transcriptional regulation that permit VSMCs to rapidly respond to inflammatory stimuli (Barreau et al., 2006).
[PDF File]FXR1 Is an IL-19-Responsive RNA-Binding Protein that ...
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Protein that Destabilizes Pro-inflammatory Transcripts in Vascular Smooth Muscle Cells Allison B. Herman, Christine N. Vrakas, Mitali Ray, Sheri E. Kelemen, Michael J. ... FXR1 0 13 6.05 6.41 Nucleic acid binding and RNA binding ATXN2 0 13 9.61 0.64 Poly(A) RNA binding and protein C-terminus binding ...
Desmoplakin and Talin2 Are Novel mRNA Targets of Fragile ...
retardation, autosomal homolog 1 (FXR1), an RNA binding protein whose loss leads to perinatal lethality in mice and cardiomyopathy in zebrafish. Methods and Results: Using RNA immunoprecipitation approaches we found that desmoplakin and talin2 mRNAs associate with FXR1 in a complex. In vitro assays indicate that FXR1 binds these mRNA targets ...
[PDF File]Bacteriophage T4 regA Protein Binds to mRNAs and Prevents ...
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the regA protein concentration required for repression of the different T4 mRNAs varies by as much as 10-fold, and we demonstrate directly that regA protein interferes with the The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement"
[PDF File]The RNA binding protein FXR1 is a new driver in the 3q26 ...
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FXR1 is highly expressed in vertebrate muscle cells and FXR1 knockout mice die early during embryogenesis, suggesting an essential role for FXR1 in development (12). In this study, we examined whether RNA binding protein FXR1 is a regulator of tumor progression in nonsmall cell lung cancer (NSCLC) and a driver of the 3q amplicon.
The Plant Journal 74, Cold shock protein 1 chaperones ...
The majority of the CSP1-associated mRNAs were constitutively expressed and stable in the cold. CSP1 abundance was correlated with improved trans-lation of ribosomal protein mRNAs during cold stress and improved maintenance of homeostasis and trans-lation of mRNAs under water-deficit stress. In summary, CSP1 selectively chaperones mRNAs, providing
[PDF File]Glucocorticoids Selectively Inhibit Translation ...
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Glucocorticoids Selectively Inhibit Translation ofRibosomalProtein mRNAsin P1798 LymphosarcomaCells ODEDMEYUHAS,1E. AUBREYTHOMPSON,JR.,2 ANDROBERTP. PERRY3* ... ribosomal protein (rp) molecules. This stoichiometry is maintained over a wide range of growth rates and other
[PDF File]European Psychiatry Evidence of an interaction between ...
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braindisorder. Inthisregard,fragileXmentalretardation syndrome-related 1(FXR1)genehas been GWAS associated with SCZ. FXR1 protein is regulated by glycogen synthase kinase-3β (GSK3β),which hasbeenimplicated in pathophysiology ofSCZ andresponse to antipsychotics (APs). rs496250 and rs12630592, two eQTLs (Expression Quantitative Trait Loci) of ...
Fragile X-related protein FXR1 controls post ...
FXR1 is knocked down, TGF-b1 is no longer able to inhibit LPS-induced TNF-a protein production, and overexpression of FXR1 suppresses LPS-induced TNF-a protein production. Targeting the p38 mitogen-activated protein kinase pathway of LPS-treated cells with small molecule inhibitors can induce FXR1 protein and mRNA expression. In summary, TGF-b1
[PDF File]Regulation of monocyte induced cell migration by the RNA ...
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cers.6 FXR1 is similar to Fragile-X-Mental Retardation Protein 1 (FMR1), 4,7-14 and is implicated at multiple levels of post-tran- scriptional control, including translation, mRNA stability and
[PDF File]Translation of Glucose-Regulated Protein 78/Immunoglobulin ...
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translation. At least one cellular mRNA, encoding a heat shock-like protein, glucose-regulated protein 78/immunoglob-ulin heavy-chain binding protein, has been discovered to be translated at an increased rate in poliovirus-infected cells at a time when the translation of other cellular mRNAs is inhibited.
[PDF File]RNA-binding protein FXR1 drives cMYC translation by ...
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Figure S3: FXR1 effects translation of downstream target mRNAs including cMYC (Related to Figure 3). (A) Molecular structures of tyrosine, tyrosyl-tRNA and puromycin. Aminoacyl-tRNA contain a hydrolyzable ester bond between their tRNA ribose moiety and the attached amino acid, whereas puromycin has a nonhydrolyzable amide bond in
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