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[DOCX File]bio manual 31 - OKALOOSA SCHOOLS
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T4 is the main secretory product of the thyroid gland and is relatively inactive when it first enters the bloodstream. One role of the hormone thyroxine 5’-deiodinase, is to convert T4 to T3 (Epstein & Brent, 1994). The interaction between T3 and the specific thyroid hormone receptors, TR
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[DOC File]Topic 18: Hormones and the Endocrine System (Ch. 45)
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1.3 Defects in Thyroid-Stimulating Hormone (TSH) synthesis. The thyroid stimulating hormone (TSH) is produced and secreted by the thyrotrophic cells of the anterior pituitary gland and it is the classic ligand for the TSH receptor (TSHR) in the thyroid.
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[DOC File]CHAPTER 11 CELL COMMUNICATION
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c.They form a hormone-receptor complex by binding to a receptor in the cytoplasm or nucleus. 4.Receptors at the Plasma Membrane a.Peptide and protein hormones and other water-soluble signaling molecules cannot cross the plasma membrane of target cells, so they must first bind to a receptor on the plasma membrane.
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[DOC File]CV2011Tzagarakis-Foster
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Some intracellular receptors (such as thyroid hormone receptors) are found in the nucleus and bind to the signal molecules there. Many intracellular receptor proteins are structurally similar, suggesting an evolutionary kinship. Concept 11.3 Transduction: Cascades of molecular interactions relay signals from receptors to target molecules in the ...
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[DOC File]CHAPTER 36
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Optimized selection experiments to isolate target gene elements of v-ErbA, a mutant form of thyroid hormone receptor. Analyzed "candidate" target genes of v-ErbA for overlapping specificity with other members of the nuclear hormone receptor family (including thyroid hormone receptor and retinoic acid receptor).
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[DOC File]Genetic Defects in Thyroid Hormone Synthesis and Action
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The intracellular receptor activated by a hormone acts as a transcription factor. The active factor, the receptor-hormone complex, activates or represses the transcription of a gene. ... PARACRINE SIGNALING. ... It increases the concentration of Ca2+ in the blood and has an effect opposite to that of the thyroid hormone calcitonin.
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[DOC File]Chapter 3d - Thyroid Disease Manager
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bind to receptor proteins in the cytoplasm or nucleus of the target cell. complex binds to specific DNA region, activating or enhancing gene transcription. examples: cortisone, testosterone, estrogen, progesterone. thyroxine – the thyroid hormone. modified form of tyrosine produced by the thyroid gland. contains 4 or 3 iodine atoms (most made ...
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Thyroid Hormone Receptor - an overview | ScienceDirect Topics
201. Kalyanaraman, H. et al. Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor. Science signaling 7, ra48, 2014. 202. Hones GS, Rakov H, Logan J et al. Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo. Proc Nat Acad Sci 114: E11323-E11332, 2017. 203.
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Thyroid hormone receptor signaling