What is a checkpoint inhibitor
[DOC File]Immune Checkpoint Inhibitors: A Game Changer in GI ...
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This landmark approval is the first ever tissue/site-agnostic indication for an anticancer therapy based solely on molecular characteristics. MSI-high/MMR-deficient solid tumors are usually immunogenic and have extensive T-cell infiltration, thereby rendering them responsive to immune checkpoint inhibitor therapy.
files-profile.medicine.yale.edu
Autoimmune diabetes mellitus is an infrequent but significant side effect of cancer treatment with immune checkpoint inhibitors. Clinicians need to know about the key features of checkpoint inhibitor-induced diabetes and have knowledge of the underlying mechanisms and their therapeutic implications.
[DOCX File]Nova Scotia Health Authority
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I wanted to bring to your attention that our mutual patient is receiving an immune checkpoint inhibitor (CPI) as part of his/her cancer treatment and as such is at risk for immune-related toxicities which may be life threatening and require urgent assessment and management.
Infinity Pharmaceuticals, Inc.
In collaboration with Arcus Biosciences, Infinity is evaluating a checkpoint inhibitor-free, novel combination regimen of eganelisib plus etrumadenant (AB928, a dual adenosine receptor antagonist) plus Doxil® in advanced TNBC patients.
[DOCX File]f6publishing.blob.core.windows.net
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Checkpoint inhibitors are monoclonal antibodies that block these pathways. Ipilimumab was the first checkpoint inhibitor immunotherapy approved by the FDA, in March 2011, for the treatment of melanoma.
[DOC File]Some Cancer Patients 'Hyperprogress' on Immunotherapy
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Another unknown is whether there is a way to overcome this. For instance, could one give a checkpoint inhibitor together with an MDM2 inhibitor, as an example, and would that mitigate whatever effect the MDM2 amplification might have [on response to the checkpoint inhibitor]? So I think this raises a lot of new questions for us.
files-profile.medicine.yale.edu
Checkpoint Inhibitor–Based Therapies: New Immuno-Oncology Targets and Resistance Mechanisms. Chair: Kurt A. Schalper, MD, PhD. Broadcast: June 5; 5:00 PM. Panel Discussions. Novel Opportunities for Interdisciplinary Care and Teleconsults in the Era of Digital Health. Speaker: Nadine Housri, MD. Session Available: June 4; 9:00 AM
[DOCX File]PD-(L)1 checkpoint inhibitor stakeholder meeting - PBS
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PD-(L)1 checkpoint inhibitor stakeholder meeting. 08 February 2019. Attendees. All invited stakeholders participated, including members of the Pharmaceutical Benefits Advisory Committee (PBAC), representatives of the Lung foundation (LF), the Medical Oncology Group of Australia (MOGA), AstraZeneca (AZ), Bristol-Myers Squibb (BMS), Merck Sharpe & Dohme (MSD), Roche and the Department of Health.
[DOCX File]Introduction - PBS
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The PBAC notes that at 1 December 2018, there are two PD-1 checkpoint inhibitors, nivolumab (Opdivo®) and pembrolizumab (Keytruda®) and one PD-L1 checkpoint inhibitor, atezolizumab (Tecentriq®), available on the PBS for a range of indications.
Journal for ImmunoTherapy of Cancer | A BMJ Oncology Journal
23.Kuo JC, Lilly LB, Hogg D. Immune checkpoint inhibitor therapy in a liver transplant recipient with a rare subtype of melanoma: A case report and literature review. Melanoma Research. 2018;28(1):61-4.
Paper .net
Prevalence of cardiotoxicity in cancer patients treated with single and combination immune checkpoint inhibitor therapy – A single centre study. Background: PD-1 and CTLA-4 inhibitors used as single agents or in combination have improved clinical outcomes in cancer patients.
[DOCX File]Australian public assessment report for Nivolumab and ...
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Peripheral T-cell assessments suggest that a given T-cell checkpoint inhibitor may modulate immune cell phenotypes rendering them more susceptible to alternative checkpoint inhibitors. In patients who did not respond to nivolumab in CA209006, CTLA-4 positive and regulatory T-cells were increased.
investors.innate-pharma.com
Monalizumab is a potentially first-in-class immune checkpoint inhibitor targeting NKG2A receptors expressed on tumor infiltrating cytotoxic CD8+ T cells and NK cells. NKG2A is an inhibitory checkpoint receptor for HLA-E. By expressing HLA-E, cancer cells can protect themselves from killing by NKG2A+ immune cells.
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