Acetyl coa to malonyl coa
[DOC File]Fed State
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ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA FASN (EC 2.3.1.85 Fatty Acid Synthase) acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+
Acetyl-CoA - Wikipedia
The primary modulators of malonyl CoA concentrations are acetyl CoA carboxylase (ACC) which makes malonyl CoA from acetyl CoA, CO2, and ATP (and requires biotin); and malonyl CoA decarboxylase (MDC) which converts malonyl CoA to acetyl CoA and CO2. Note that acetyl CoA can be supplied on the cytosolic side from breakdown of citrate.
[DOC File]open.umich.edu
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An acetyl-CoA and malonyl-CoA are then transferred to ACP molecules by acetyl-CoA transacylase and malonyl-CoA transacylase. The condensing FAS enzyme -keto-ACP synthase decarboxylates the malonyl moiety then transfers the remaining 2-carbons to the carbonyl carbon of the acetyl group to give a four carbon chain containing a ketone group.
[DOC File]California State University, Dominguez Hills
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Increase in Malonyl CoA (from + Acetyl CoA Carboxylase) inhibits CPT-I. Increase in Citrate (high flux of carbon into glycolysis and through the TCA cycle) activates Acetyl CoA Carboxylase _____ Fasted State (Trauma, Starvation) Low Plasma Glucose + Glucagon. Increase: gluconeogenesis, glycogenolysis, lipolysis/b-oxidation ...
[DOCX File]مواقع اعضاء هيئة التدريس | KSU Faculty
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To synthesize palmitoyl-CoA starting with 8 acetyl-CoAs we would have to convert seven acetyl-CoA to malonyl-CoA and then run 7 cycles of fatty acid biosynthesize with each cycle consuming 3 NADPH. Production of 7 malonyl-CoA would consume 7 ATP. Consumption of 14 NADPH would account for 64 ATP. The total ATP cost for production is 71 ATP.
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The acetyl CoA is converted into malonyl CoA that is used to synthesize fatty acids. Figure 6. summarizes the pathways of lipid metabolism. Figure 6. Lipid Metabolism. Lipids may follow one of several pathways during metabolism. Glycerol and fatty acids follow different pathways.
[DOC File]Chapter 25
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step in the synthesis of butyric acid (HO2CCH2CH2CH3) starting with acetyl CoA (CH3COSCoA) and malonyl CoA (HO2CCH2COSCoA). Show every intermediate , …
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