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Fatty Acid Metabolism - Metabolic Pathways | Sigma-Aldrich
Thus, malonyl-CoA produced by ACC-2 is exclusively involved in regulation of fatty acid oxidation (by inhibiting acycarnitine transferase I) , whereas that produced by ACC-1 is utilized in fatty acid synthesis. Phosphorylation of ACC, for example a result of activation of PKA by stress or exercise switches on fatty acid oxidation (via phosphorylation and inhibition of ACC-2 …
fatty acid synthesis steps

[DOC File]Cellular Biochemistry Notes
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A. Fatty acid synthesis occurs within the cytosol, while fatty acid degradation occurs. within the mitochondrial matrix. B. Three carbon units are added as malonyl-CoA in fatty acid synthesis, while two. carbon units are liberated as acetyl-CoA in fatty acid degradation. C. NADPH is the electron donor in fatty acid synthesis, while FAD and NAD+ are . electron acceptors in fatty acid ...
acetyl coa fatty acid synthesis

[DOC File]Chapter 25
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-The synthesis of fatty acids from acetyl-CoA and malonyl-CoA involves 7 enzymatic reactions: Fig 19-19, 19-22-1 & 2 are priming reactions in which the synthase is "loaded" with . the condensation reaction precursors -3 the condensation reaction--malonyl-ACP is decarboxylated with . the resulting carbanion attacking the acetyl-thioester to form a . ketoacyl-ACP-4-6 are the …
fatty acid synthesis pathway

[DOC File]FATTY ACID BIOSYNTHESIS
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Fatty acid synthesis takes place in smooth endoplasmic reticulum. Biosynthesis requires the participation of a three-carbon intermediate, malonyl-CoA. Malonyl-CoA Is Formed from Acetyl-CoA and Bicarbonate:-The formation of malonyl-CoA from acetyl-CoA is an. irreversible process, catalyzed by acetyl-CoA carboxylase. the enzyme contains a biotin prosthetic group covalently …
fatty acid synthesis ppt

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It also stimulates fatty acid synthesis. 2. Malonyl-CoA is produced by acetyl-CoA carboxylase at the expense of one high-energy phosphate bond. 3. Acetyl-CoA carboxylase is active in a polymeric state. The equilibrium between active polymer and inactive protomers is affected by citrate and palmitoyl-CoA. Citrate is an allosteric activator of the enzyme and shifts the …
acetyl coa to malonyl coa

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Malonyl CoA may join the free ACP-SH group. FA synthesis is carried out by extending the acid chain by 2 consecutive two-carbon units according to the reaction sequence shown in Fig. 16.9. In the next steps, the resulting acyl chain is transferred to the -SH group of cysteine and another malonyl-CoA residue is attached to ACP-SH. This reaction ...
biosynthesis of fatty acid

Malonyl coa fatty acid synthesis