Acute systemic toxicity
[PDF File]Sodium chloride - ACuteTox
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性 Acute systemic toxicity 発熱性 Material-Mediated Pyrogenicity 全身毒性 Subacute / Subchronic toxicity ... materials with a known reproductive or developmental toxicity, devices with relevant target populations (e.g., pregnant women), and/or devices where there is the probability for local presence of device materials in the ...
[PDF File]Clinical In-Vivo Studies
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Bondesson, I. (1998) MEIC evaluation of acute systemic toxicity. Part V. Rodent and human toxicity data for the 50 reference chemicals. ATLA 26, 571-616. 6. Arieff, A.I., Guisado, R. (1976) Effects on the central nervous system of hypernatremic and hyponatremic states. Kidney Int 10, 104-116. Written by Ada Kolman, November 2005; revised March ...
ENVIRONMENT DIRECTORATE JOINT MEETING OF THE …
Clinical In-Vivo Studies ... The test article, IrriSept Wound Debridement and Cleansing System, was evaluated for acute systemic toxicity in mice. A single 20 mL/kg dose of test article one, IrriSept with 0.05% CHG, was injected into a group of 5 animals by the intraperitoneal route. Similarly,
Chapter IV. Guidelines for Toxicity Tests
Herein we present a first toxicity screening of Upsalite®, where the material is analyzed for in vitro cytotoxic-ity using a human dermal fibroblast cell line, for skin irritation in in vivo rabbits and for in vivo acute systemic toxicity in mice. 2. Materials and Methods 2.1. Chemicals and Reagents
[PDF File]US Environmental Protection Agency Office of Pesticide ...
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3. ACUTE, SUBCHRONIC, AND CHRONIC TOXICITY 3.1. SCOPE AND LIMITATIONS The acute, subchronic, and chronic toxicology of the chlorinated dioxins, dibenzofurans, biphenyls, and related compounds have been reviewed extensively in recent years. This chapter summarizes knowledge on the toxicology of tetrachlorodibenzo-p-dioxin (TCDD), but also
[PDF File]Predictive Models for Acute Oral Systemic Toxicity
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Draft Chapter IV. Guidelines for Toxicity Tests IV C 2. Acute Oral Toxicity Tests Acute toxicity tests can provide preliminary inf ormation on the toxic nature of a material for which no
[PDF File]Cytotoxicity, in Vivo Skin Irritation and Acute Systemic ...
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A Practical Guide to ISO 10993-11: Designing Subchronic and Chronic Systemic Toxicity Tests Richard F. Wallin Created 09/01/1998 - 03:00 Home [1] - > News [2] - > A Practical Guide to ISO 10993-11: Designing Subchronic and Chronic Systemic Toxicity Tests A Practical Guide to ISO 10993-11: Designing Subchronic and Chronic Systemic Toxicity Tests
[PDF File]A Practical Guide to ISO 10993-11: Designing Subchronic ...
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Acute toxicity testing of chemicals-Opportunities to avoid redundant testing and use alternative approaches. Crit Rev Toxicol 40: 50-83. Seidle et al. 2011. Examining the regulatory value of multi-route mammalian acute systemic toxicity studies. ALTEX 28:95-102. Moore et al. 2013. Can acute dermal systemic toxicity tests be replaced with oral ...
[PDF File]3. ACUTE, SUBCHRONIC, AND CHRONIC TOXICITY 3.1. SCOPE …
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No. 24, Guidance Document on Acute Oral Toxicity Testing (2001) No. 25, Detailed Review Document on Hazard Classification Systems for Specifics Target Organ Systemic Toxicity Repeated Exposure in OECD Member Countries (2001) No. 26, Revised Analysis of Responses Received from Member Countries to the Questionnaire on Regulatory Acute Toxicity Data
Acute Systemic Toxicity | AltTox.org
Predictive Models for Acute Oral Systemic Toxicity . Background & Scope. One of ICCVAM’s high priority efforts is to develop alternative test methods for the U.S. Environmental Protection Agency (EPA) “six pack” tests: acute oral, dermal, and inhalation systemic toxicity tests and tests to determine eye and skin irritation and skin
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