Acute toxicity test
Test Guideline No. 203
or other difficult to test chemicals, it should be referred to the Guidance Document No. 23 (OECD, 2019) on aquatic toxicity testing of difficult test chemicals. Where test chemicals are predicted to have no acute toxic effects at relevant test concentrations, it is recommended to consult the relevant regulatory authorities. Some regulatory
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2. Intra- and inter-laboratory precision of acute toxicity tests with. Daphnia magna. using a standard effluent 12 3. Inter-laboratory precision of acute toxicity tests with aquatic organisms, using reference toxicants 13 4. Interlaboratory study of acute toxicity test precision, 1990: Summary of responses using KCL as the reference toxicant 14 5.
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of the animals, on average 2-4 steps may be necessary to allow judgement on the acute toxicity of the test substance. This procedure is reproducible, uses very few animals and is able to rank substances in a similar manner to the other acute toxicity testing methods (Test Guidelines 420 and 425).
[PDF File]203 - OECD
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203 Adopted: 17.07.92 OECD GUIDELINE FOR TESTING OF CHEMICALS Adopted by the Council on 17th July 1992 Fish, Acute Toxicity Test INTRODUCTION 1. This new version of the guideline, originally adopted in 1981 and first updated in 1984, is
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31 carrying out a fish acute toxicity test according to this guideline, it should be considered 32 whether information on fish acute toxicity could be derived with alternative methods in a 33 weight-of-evidence approach. This would include the use of QSAR, read-across, fish 34 embryos (5), fish cell lines and others.
Chapter IV. Guidelines for Toxicity Tests
a. Limit Tests To determine the acute toxicity of a new food additive that i s not expected to be particularl y toxic, 5 gm (or ml) of the compound/kg body weight of the test animal should be ...
[PDF File]ACUTE TOXICITY TEST REPORT
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ACUTE TOXICITY TEST REPORT By authority of PA 451 of 1994, as amended. INSTRUCTIONS: Use this form to report acute toxicity test results. Use separate forms for more than 1 test. Attach all raw data sheets to this report unless reporting for NPDES permit application. 1. …
[PDF File]OECD GUIDELINE FOR THE TESTING OF CHEMICALS
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OECD GUIDELINE FOR THE TESTING OF CHEMICALS Acute Inhalation Toxicity INTRODUCTION 1. OECD Guidelines are periodically reviewed in the light of scientific progress, changing regulatory needs, and animal welfare considerations. The original acute inhalation Test Guideline 403 was adopted in 1981.
Earthworm, Acute Toxicity Tests
page 2 "Earthworm, Acute Toxicity Tests" The simple contact test is easy to perform and gives reproducible results with the recommended species. The artificial soil test gives toxicity data more representative of natural exposure of earthworms to chemicals. •D e f i n i t i o n s a n d u n i t s LC50 in this Test Guideline is the median ...
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The preferred test species for evaluation of acute toxicity by the oral and inhalation routes is the rat, while the rat or rabbit are preferred for evaluation of acute dermal toxicity. As noted by the . 3 CG/HCCS, "Test data already generated for the classification of chemicals underexisting systems
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