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Atypicals differ from classical dopamine antagonists in possessing (perhaps) greater efficacy for both positive and negative symptoms while producing fewer neurological side effects than the classical agents possess. The atypical antipsychotic clozapine was found to exert superior antipsychotic efficacy at doses producing only 20%-40% D2 receptor occupancy. Clozapine has a higher D4/D2 ...
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Choosing an Antipsychotic and Why CME
1 Nora Volkow, et al., Therapeutic Doses of Oral Methylphenidate Significantly Increase Extracellular Dopamine in the Human Brain, The Journal of Neuroscience, 2001, 21:RC121:1-5. 2 Nora Volkow, et al., Dopamine Transporter Occupancies in the Human Brain Induced by Therapeutic Doses of Oral Methylphenidate, Am J Psychiatry 155:1325-1331, October 1998.
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Noradrenaline and adrenaline exert beta effects at low doses and alpha effects at high doses. b. Dobutamine exerts its actions via alpha effects b2>a. c. Inotropic agents act ultimately by increasing intracellular calcium . d. Dopamine exerts different effects at different doses. e. Theophylline is a positive inotrope. 28. milrinone. a. has a short half life because of rapid reuptake and ...
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This is thought to explain the orthostatic blood pressure effects caused by therapeutic doses of MAO inhibitors. The major biochemical difference between the norepinephrine and dopamine neurons is the presence of a vesicle bound copper containing enzyme in the neurons of the norepinephrine neurons. This enzyme is . dopamine beta hydroxylase. It catalyses the synthesis of norepinephrine from ...
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[DOC File]NEUROTRANSMITTER SYSTEMS - University of Toronto
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3. Toxicity : Most adverse effects are dose-dependent. a- Gastrointestinal effects: Anorexia, nausea, and emesis (primary side effects due to dopaminergic mimetic effect). These can be reduced by taking the drug in divided doses. Tolerance to the emetic action of …
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[DOCX File]Dopamine - Better Safer Care
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Dopamine activates α & β . and D1 & D2- dopamine receptors. (1) Cardiovascular: Dopamine exerts a stimulatory effect on the β1 receptors of the heart, having both inotropic and chronotropic effects (Figure 6.12). At very high doses, dopamine activates α-receptors on the . …
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[DOC File]Psychotic Disorders - Brown University
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However, some antipsychotics with dissociation constants between 1.8 and 10 nM can exhibit dose-dependent extrapyramidal signs (EPS), because the high doses "out-compete" dopamine for binding to ...
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Renal-Dose Dopamine: Myth or Ally in the Treatment of Acute
At low doses, dopamine receptor stimulation predominates, causing renal, mesenteric and coronary blood vessel vasodilation without any significant effect on cardiac output or blood pressure. At infusion rates of 3 to 10 microg/kg/min, β 1-receptor activation promotes positive inotropic and some chronotropic effects, increasing stroke volume, heart rate and cardiac output.At high infusion ...
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Dopamine doses and effects