Glucocorticoid receptor cns
[DOC File]Organism - University of Kentucky
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Dr. Jacobson’s lab has demonstrated opposing effects of two classes of antidepressants on glucocorticoid feedback and CNS glucocorticoid receptor expression. Her lab is currently investigating the role of aberrant glucocorticoid signaling in depression-like behavior using forebrain glucocorticoid receptor knockout models.
[DOC File]3-03-08 Adrenal Physiology & Pharmacology
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Major depression may be due, in part, to dysfunction of glucocorticoid receptors in the CNS and a resultant lack of cortisol effect in the brain. Pariante CM. The glucocorticoid receptor: part of the solution or part of the problem? J Psychopharmacol. 2006 Jul;20(4 Suppl):79-84.
[DOCX File]A Clinical Approach to the Diagnosis and Treatment of ...
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Glucocorticoid Receptor Agonist Osteoporosis, Glucose Intolerance, Cataracts, Myopathy, Manic/Depression ↑BP, Ulcers, Body Fat, ↓ Growth High Potency, Little effect on MR Fluticasone Glucocorticoid Receptor Agonist Asthma (Inhaled) Rapid first pass elimination, Most lipophilic. Combined with -2 agonists, Longest t1/2
Frontiers | Stress, glucocorticoid hormones, and hippocampal neur…
Glucocorticoid Function - help regulate BP, sugar, CNS, stress response: Blood pressure - help catecholamines do their thing ( maintain viable blood pressure. Blood sugar - aids in metabolic homeostasis ( maintain viable blood sugar. CNS integrity - helps maintain CNS function. Stress response - regulates response to stress (cortisol
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