Low acth and low cortisol
[DOC File]3-03-08 Adrenal Cortex Disease
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A majority of patients with fatigue plus other hypocortisolemic symptoms, AM serum cortisol levels
[DOC File]Cortisol, acute responses to exercise
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The secretory rates of CRF, ACTH, and cortisol are high in the early morning but low in the late evening. The plasma cortisol level ranges between a high of about 20 mg/dl an hour before arising in the morning and a low of about 5 mg/dl around midnight. This effect results from a 24-hour cyclical alteration in the signals from the hypothalamus ...
[DOC File]ENDOCRINE DISORDERS
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low BP, slow cognition, slowed reflexes; no breast-feed, amenorrhea. Labs - will present with . single hormone. deficiency, or deficiency of . all anterior pituitary hormones: ACTH deficiency - will present with . low cortisol, and . low glucose (glucocorticoid) TSH deficiency - have a . low T4 . and an . inappropriately normal TSH (should be ...
[DOCX File]A Clinical Approach to the Diagnosis and Treatment of ...
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Low aldosterone: seen in primary alone due to dependence on RAS, not ACTH. Hyponatremia: hypotension, ( CO, ( renal perfusion, weakness, shock. Hyperkalemia. Dx: Decreased plasma cortisol level. Low plasma ACTH in secondary. Standard ACTH test (definitive for primary): administered IV with measurement of plasma cortisol at the end of infusion
[DOC File]3-03-08 Anterior Pituitary Disorders
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Threshold adrenocortical responses are obtained in humans with doses of ACTH as low as 30-50 ng whereas maximal responses occur with doses of 250-400 ng. The consequent duration of cortisol response is dependent on the concentration of released ACTH.
Hypopituitarism (Panhypopituitarism) Workup: Approach Consider…
Dx - assess cortisol excess, determine if pathologic, and ACTH-dependence: Cortisol excess - see if 24 hr urine cortisol > 100. Pathologic excess - low-dose dexamethasone should suppress cortisol… won’t if diseased. ACTH dependence - is ACTH normal/high (ACTH-dependent), or low (ACTH-independent)
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