Pde5 inhibitors contraindications
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PDE5 4.3-5.2 3.5 0.14 6.74 Like the other marketed PDE5 inhibitors, avanafil is highly bound to plasma proteins and metabolized primarily by CYP3A4 (Table 2). Its half-life, onset of action and duration of action are similar to those of sildenafil and vardenafil (Tables 2 and 3). Table 2 Pharmacokinetics of PDE5 Inhibitors. Agent Absolute
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[PDE5] inhibitors, intra-urethral alprostadil, intracavernous vasoactive drug injection, vacuum constriction devices, and penile prosthesis implantation. Oral phosphodiesterase type 5 inhibitors, unless contraindicated, should be offered as a first-line of therapy for erectile dysfunction.
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Caution is advised when PDE5 inhibitors are coadministered with nonselective alpha (α1)-blockers. PDE5 inhibitors, including CIALIS, and alpha-adrenergic blocking agents are both vasodilators with blood-pressure-lowering effects. When vasodilators are used in combination, an additive effect on blood pressure may be anticipated.
[DOC File]Pharmacotherapy of _Erectile Dysfunction_______________
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There is an awareness that other PDE5 inhibitors (e.g. vardenafil, once daily tadalafil) are often prescribed on private prescriptions. It is expected that this activity is likely to continue, but this guidance refers to NHS prescribing ONLY . Provide education for using these drugs – …
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Alcohol and PDE5 inhibitors, including avanafil, are mild systemic vasodilators. The interaction of avanafil with alcohol was evaluated in a clinical pharmacology trial. Alcohol was administered at a dose of 0.5 g/kg, which is equivalent to approximately 88.7 mL of 80-proof vodka in a 70kg male, and avanafil was administered at a dose of 200 mg.
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The currently available therapies that should be considered for the treatment of erectile dysfunction include the following: oral phosphodiesterase type 5 [PDE5] inhibitors, intra-urethral alprostadil, intracavernous vasoactive drug injection, vacuum constriction devices, …
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Concomitant use of riociguat with PDE5 inhibitors, including tadalafil, is contraindicated (see section 4.3). 5-alpha reductase inhibitors (5-ARIs) In a clinical trial that compared tadalafil 5mg coadministered with finasteride 5mg to placebo plus finasteride 5mg in the relief of BPH symptoms, no new adverse reactions were identified.
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