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Toxicology Testing Using Animals
The common testing methods (updated or new) using laboratory animals (mostly rats and mice) are those for assessment of acute, subchronic, chronic oral, dermal inhalatory toxicity, skin and eye irritation/ corrosion, sensitizing potential, prenatal toxicity, reproduction toxicity, carcinogenicity, most recently updated or newly adapted being ...
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[DOC File]TOXICOLOGY STUDIES IN LABORATORY ANIMALS
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Animals may serve as models for humans . Although some people object to animal testing on ethical grounds, animal testing has been used because mammals, especially, have similar systems to humans. Other techniques, using cells, bacteria, or tissue, can help decrease the number of live animals used. Dose-response analysis is a mainstay of toxicology
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[DOC File]NWABR
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The use, care, and transportation of animals for training and for toxicological research and testing for the purpose of protecting human and animal health and the environment must comply with all applicable animal welfare laws. 2. When scientifically appropriate, alternative procedures that reduce the number of animals used, refine the use of ...
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[DOC File]Chapter 10 - Toxicology and environmental health
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Case study: Explain how thalidomide validates the importance of testing multiple animals when testing for toxicity. Describe how evolution is fundamental to the use of model systems in toxicology. Describe the relationship between genetic phylogeny and similarity in …
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[DOC File]Handout 4: Guiding Principles in the Use of Animals in ...
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In contrast to pharmaceutical testing, virtually all toxicity evaluations are conducted with experimental laboratory animals. In 1958, with an amendment to the Food, Drug and Cosmetic Act (FDCA), FDA was required to approve all new food additives.
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[DOCX File]Society of Toxicology
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3. Basic toxicology principles govern ingredient and product safety testing. The safety evaluation process includes safety-testing in animals because adequate alternatives are not available. 4. Evaluating cosmetic information requires a critical review of the scientific data and the information source. 5.
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Toxicology testing on animals