Acetyl coa carboxylase pathway

• Subcellular localization of acetyl-CoA carboxylase in the apicomplexan ...

  Some key enzymes of the fatty acid biosynthetic pathway were shown to be imported to the apicoplast (5, 6), providing a strong argument for the organelle as a site of de novo fatty acid biosynthesis. We have shown previously that T. gondii encodes two isozymes of acetyl-CoA carboxylase (ACC), a biotin-

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• Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid ...

  acetyl-CoA carboxylase 1 (ACC1, encoded by acetyl-CoA carboxylase alpha (ACACA)), which catalyzes acetyl-CoA carboxylation to form malonyl-CoA. Both acetyl-CoA and malonyl-CoA are substrates for long-chain fatty acid synthesis (14). Therefore, targeting ACACA to inhibit de novo fatty acid synthesis has been tested in multiple types of cancer ...

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• Acetyl Coenzyme A Carboxylase - Journal of Biological Chemistry

  acetyl-CoA carboxylase synthesis and degradation in rat liver. Fatty acid synthesis in rat liver is inhibited by fasting; when fasted animals are subsequently fed a diet low in fat there is a ... synthesis pathway, mediates these effects on fatty acid syn- thesis. This enzyme is rate-limiting for fatty acid synthesis, and its activity, as ...

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• Human Acetyl-CoA Carboxylase 2 - Journal of Biological Chemistry

  CoA is also involved in the synthesis of polyketides (3), and there are indications that it may be involved in the synthesis of an as yet unknown compound or pathway (4, 5). Moreover, malonyl-CoA is a regulator of the palmitoyl-CoA–carnitine shuttle system that is involved in the mitochondrial oxidation of long chain fatty acids (6).

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• Hormonal Regulation of Acetyl-CoA Carboxylase Isoenzyme Gene Transcription

  Glucose is catalyzed via the glycolytic pathway to pyruvate and then oxidized to generate ATP. However, excess glucose is converted to fatty acid via the li-pogenic pathway by a number of enzymes including acetyl-CoA carboxylase (ACC) [1]. Short-term glu-cose/lipid metabolism is regulated by allosteric chang-

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• [PDF File]A B C D E F G H I J K L M - Stanford University

  https://info.5y1.org/acetyl-coa-carboxylase-pathway_1_05aaf6.html

  carboxylase methylmalonyl-CoA Methylmalonyl-CoA mutase succinyl-CoA TCA isobutyryl-CoA odd-chain fatty acyl-CoA BCKAD NAD+ NADH CoA α-ketoisovalerate B 6 Transaminase α-ketoglutarate glutamate valine ADP α-ketoisocaproate α-keto-β-methylvalerate α-ketoisovalerate (last three carbons only) (multiple steps) acetoacetate HMG-CoA lyase acetyl ...

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• Feedback regulation of plastidic acetyl-CoA carboxylase by 18:1-acyl ...

  cessful engineering of this pathway to increase oil yield. A variety of mechanisms contribute to feedback inhibition of fatty acid synthesis in animals, fungi, and bacteria. In rats and yeast, pal-mitoyl-CoA, an intermediate of fatty acid synthesis, binds to and inhibits acetyl-CoA carboxylase (ACCase) (4). Also in yeast,

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• Acetyl Coenzyme A Carboxylase - Journal of Biological Chemistry

  Acetyl-CoS carboxylase, a biotin-dependent enzyme, catalyzes the formation of malonyl-Co-4 from acetyl-CoA, the committed step in fatty acid synthesis, and is a regulatory enzyme in this pathway (1, 2). Investigators in several laboratories found that the enzyme from animal tissues is activated by citrate or iso-

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• of Acetyl-CoA Carboxylase from Grasses - JSTOR

  grasses of the second enzyme common to these pathways, acetyl-CoA carboxylase (EC 6.4.1.2), by alloxydim, sethoxydim, and clethodim, and the much weaker inhibition of this enzyme in tolerant broadleaf species. MATERIALS AND METHODS Chemicals. [14C]Acetate and [14C]acetyl-CoA were obtained from NEN-Dupont. Analytical grade clethodim was synthesized

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• Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase ...

  evidence that the AMPK/ACC pathway may operate as a mechanism to sense and respond to the lipid energy charge ofskeletalmusclecells.—Fediuc,S.,M.P.Gaidhu,andR.B. Ceddia. Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells. J. Lipid Res. 2006. 47: 412–420.

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• Determination of Acetyl-CoA and Malonyl-CoA in Germinating Rice Seeds ...

  carboxylation of acetyl-CoA, which is catalyzed by acetyl-CoA carboxylase (ACCase). Consequently, AC-Case can be considered to be the starting enzyme of fatty acid biosynthesis, and it is the major site of the regulation of this anabolic pathway.2) Grass ACCase is the primary target site of the aryloxyphenoxypropionic acid herbicides and the ...

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• [PDF File]Fatty Acid Biosynthesis - California State University, Northridge

  https://info.5y1.org/acetyl-coa-carboxylase-pathway_1_8516ec.html

  • Acetyl CoA carboxylase is the rate-limiting step of FA biosynthesis. It is allosterically inhibited by palmitoyl CoA and activated by citrate. • Palmitoyl CoA also inhibits the citrate shuttle and thus slows down FA biosynthesis. • Malonyl CoA and acetyl CoA inhibit β-oxidation. • Acetyl CoA inhibits the final step of β-oxidation ...

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• Chloroplast acetyl-CoA carboxylase activity is 2-oxoglutarate regulated ...

  ries out the first committed step of the lipid biosynthetic pathway by converting acetyl-CoA to malonyl-CoA (25). The Arabidopsis genome also encodes two homomeric ACCases, ACC1 and ACC2, which are dimeric forms located in the cytosol (26) with the exception of the grass family in which they are also found in plastids (27).

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• Overproduction of Acetyl-CoA Carboxylase Activity Increases the Rate of ...

  branes of all living organisms excepting the Archaea. Acetyl-CoA carboxylase (ACC)1 catalyzes the first committed step of the fatty acid synthetic pathway, the formation of malonyl-CoA from acetyl-CoA plus bicarbonate, and ACC has often been postulated to be a rate-controlling step in fatty acid biosynthe-sis (see, e.g., Refs. 1 and 2 ...

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• Synthesis of C 5 -dicarboxylic acids from C 2 -units involving ... - PNAS

  Crotonyl-CoA carboxylase/reductase (or its gene) can be used as a marker for the presence of the ethylmalonyl-CoA pathway, which functions not only in acetyl-CoA assimilation. In Streptomyces sp., it may also supply precursors (ethylmalonyl-CoA) for antibiotic biosynthesis. For methylotrophic bacteria such as Methylobacte-

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• [PDF File]NON-RADIOACTIVE ASSAY FOR ACETYL-CoA CARBOXYLASE ACTIVITY

  https://info.5y1.org/acetyl-coa-carboxylase-pathway_1_de9d63.html

  Acetyl-CoA carboxylase is a key enzyme in oil biosynthesis and is critical for the oil deposition pathway. This biotinylated enzyme catalyzes the first committed step in fatty acid biosynthesis, the ligation of a carbon to acetyl-CoA to form malonyl-CoA. The acetyl-CoA carboxylase holoenzyme has four distinct protein domains:

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• Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

  terized substrate of AMPK is acetyl-CoA carboxylase (ACC), and AMPK inactivates ACC by phosphorylating its serine res-idue (Ser-79) (6, 7). ACC is the key regulatory enzyme of the biosynthesis of fatty acids such as palmitate, and it catalyzes the formation of malonyl-CoA, the intermediate in the fatty acid

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• Docking of acetyl-CoA carboxylase to the plastid envelope ... - NSF

  by regulation of acetyl-coenzyme A carboxylase (ACCase; EC.6.4.1.2) which catalyzes the first committed step in FAS, the ATP-dependent formation of malonyl-CoA from acetyl-CoA and bicarbonate4,5. In the plastids of dicots and non-graminaceous monocots, the predominant form of ACCase is a multisubunit,

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• Acetyl-Coenzyme A carboxylase inhibition Delivers, as Anticipated, for ...

  Figure 1.Cytosolic acetyl-coenzyme A (CoA) carboxylase 1 and mito-chondrial acetyl-CoA carboxylase 2 convert acetyl-CoA to malonyl-CoA, and this is the highly regulated rate-limiting step in fatty acid synthesis. GS0976 inhibits both iso-forms of acetyl-CoA carboxylase and results in a reduction in the produc-tion of malonyl-CoA thus

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