Acute oral toxicity category
[PDF File]Acute Oral LD50 - US EPA
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Acute Oral LD50 MRID No._____ ACUTE ORAL TOXICITY STUDY SYNOPSIS AND TOXICITY CATEGORY RECOMMENDATION PRODUCT NAME: (EPA file name) EPA REG. NO./FILE SYMBOL: (EPA Reg. No., registrant’s number and product number if already registered, otherwise leave blank) REGISTRANT: (Name and address as on file with EPA) 1.0 STUDY TITLE: 2.0 LI: GUIDENE
[PDF File]EPA Toxicity Category Rating System
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Very Low Toxicity EPA Toxicity Rating Acute Oral Up to and including 50 mg/kg >50 thru 500 mg/kg >500 thru 5000 mg/kg >5000 mg/kg Category IV Very Low Toxicity Acute Dermal Up to and including 200 mg/kg >200 thru 2000 mg/kg >2000 thru 5000 kmg/kg >5000 mg/kg Category IV Very Low Toxicity Acute Inhalation Up to and including 0.05 mg/liter >0.05 ...
[PDF File]US Environmental Protection Agency Office of Pesticide Programs
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dermal acute toxicity for conventional, antimicrobial, and biochemical pesticides may be waived if any of the following criteria are met: • The test material has been placed in Toxicity Category I for primary dermal irritation. Such products will be placed in dermal Toxicity Category I 0F 1 on the basis of potential dermal effects.
Metofluthrin: Acute Oral Toxicity Classification Background - Europa
mouse is a valid basis on which to derive an acute oral LD 50 value and associated hazard classification for acute exposure by the oral route or indeed any other route. Furthermore, with reference to the CLP regulation (Annex I: 3.1.2.2.1): “The preferred test species for evaluation of acute toxicity by the oral and inhalation routes is
[PDF File]OECD Test Guideline 420: Acute Oral Toxicity - Fixed Dose Procedure (2001)
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Acute Oral Toxicity – Fixed Dose Procedure INTRODUCTION . 1. OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific ... testing of animals in GHS Category 5 ranges (2000-5000mg/kg) is discouraged and should only be considered when there is a strong likelihood that results of such a test have a direct ...
[PDF File]Assessment of Acute Oral Toxicity for Mixtures using In Silico Modeling ...
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the majority of existing toxicity data and tools are for single compounds • This is particularly pertinent given the number of unique AF-relevant mixtures used across the force. • Therefore, our researchers evaluated the prediction of GHS acute oral toxicity category
[PDF File]Chapter IV. Guidelines for Toxicity Tests
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However, if a petitioner decides to conduct an acute oral toxicity test, alternative test protocols can provide useful information about the acute toxicity of a substance.3 These
[PDF File]US EPA - Label Review Manual - Chapter 7: Precautionary Statements
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the pesticide product meets the criteria of Toxicity Category IV by all routes of exposure. If a signal word is used in this case, it must be “Caution”. 2. Determining the Signal Word. The Signal Word is determined by the most severe toxicity category assigned to the five acute toxicity studies (see table 1) or by the
[PDF File]Acute Oral Toxicity Needs/Requirements - National Toxicology Program
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Category. Oral LD. 50. Highly Toxic. ≤50 mg/kg. Toxic >50 to 5000 mg/kg • Poison Prevention Packaging Act – Child-resistant packaging must be applied to hazardous household ... • Acute oral toxicity data are typically used for hazard classification and labeling and risk evaluation
[PDF File]Info Acute Toxicity - Inhalation July 2017 - SCHC
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Exposure route Classification Category Converted Acute Toxicity point estimate Inhalation – Gases (ppmV) 0 < Category 1 ≤ 100 ... into any of the acute toxicity categories, or have an oral or dermal LD50 greater than 2000 but less than or equal to 5000 mg/kg body Page 3 of 4 weight (or the equivalent dose for inhalation); (b) Ignore ...
[PDF File]Acute Toxin Fact Sheet - Environmental Safety, Sustainability and Risk
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Acute Toxicity (Oral, Dermal or Inhalation) – Category 4 Harmful Acute Toxicity (Oral, Dermal or Inhalation) – Category 5 No Pictogram May be harmful . The severity of a toxin is categorized by concentrations of the LD. 50 (lethal dose for 50% of an animal population) of the substance
[PDF File]US EPA - Pesticides - Fact Sheet for Deet
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Toxicity In studies using laboratory animals, DEET generally has been shown to be of low acute toxicity. It is slightly toxic by the eye, dermal and oral routes and has been placed in Toxicity Category III (the second lowest of four categories) for these effects. [NOTE: For acute oral, dermal, ocular and inhalation toxicity:
[PDF File]OECD Test Guideline 423: Acute Oral Toxicity - Acute Toxic Class Method ...
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Acute Oral Toxicity – Acute Toxic Class Method INTRODUCTION . 1. OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific ... concern, testing of animals in GHS Category 5 ranges (2000-5000mg/kg) is discouraged and should only be considered when there is a strong likelihood that results of such a test ...
[PDF File]Guidance for Waiving Acute Dermal Toxicity Tests for Pesticide ...
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Toxicity Category for the oral acute toxicity study, the labelling requirements would have been equally or more protective. For the two remaining chemicals (less than 1%), as noted above, factors other than the dermal acute toxicity may influence labelling requirements. In some cases,
[PDF File]Chemical Hazard Classification and Labeling: Comparison of OPP ... - US EPA
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Category IV has no upper limit. GHS Category 5 covers chemicals with toxicities expected to fall in the range of oral and dermal LD50 of 2000 mg/kg -5000 mg/kg, or equivalent doses for inhalation toxicity. • The basis of classification in both systems is the same: LD/LC50 values or “acute toxicity estimates” of the LD/LC50 .
[PDF File]Chapter 5: ACUTE TOXICITY DEFINITIONS CLASSIFICATION CRITERIA FOR ...
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Chemicals can be allocated to one of five toxicity categories based on acute toxicity by the oral, dermal or inhalation route according to the numeric criteria expressed as (approximate) LD50 ... 5. Category 1, the highest toxicity category, has cut off values of 5 mg/kg by the oral route, 50 mg/kg by the dermal route, 100 ppm for gases or ...
[PDF File]ANNEX 3 CODIFICATION OF HAZARD STATEMENTS, CODIFICATION AND USE OF ...
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A3.1.1.1 Hazard statement means a statement assigned to a hazard class and category that describes the nature of the hazards of a hazardous product, including, where appropriate, the degree of hazard. ... H300 Fatal if swallowed Acute toxicity, oral (chapter 3.1) 1, 2 H301 Toxic if swallowed Acute toxicity, oral (chapter 3.1) 3
[PDF File]GHS/HazCom Information Sheet Workgroup Acute Toxicity - Oral ... - SCHC
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Page 3 of 3 below for oral, dermal or inhalation toxicity: where: Ci = concentration of ingredient i n ingredients and i is running from 1 to n ATEi = acute toxicity estimate of ingredient i A.1.3.6.2 Data are not available for one or more ingredients of the mixture Where an ATE is not available for an individual ingredient of the mixture, but available information provides a derived conversion
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