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Cholesterol metabolism and colorectal cancers - ScienceDirect
Cholesterol Metabolism and Its Role in Cancer Normal cholesterol homeostasis Cholesterol is an essential lipid for maintaining cellular homeostasis (28). Besides being a precursor for steroid hor-mones, and being an essential component of plasma mem-branes, it is also enriched in lipid rafts and plays a key role in intracellular signal ...
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Cholesterol Metabolism: A Potential Therapeutic Target in ...
of cancer, this results in inhibition of tumor growth and tumor progression, and apoptosis. Specifically, orlistat anti-cancer activity has been shown in prostate and breast cancer cells [25]. Interestingly, this has implications for the activity of the Her2/ neu . oncoprotein. Treatment of
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[PDF File]Cholesterol and Cancer , in the Balance
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Fig. 1. Regulation of lipid metabolism by oncogenic signalling pathways. Many cancer cells show high rates of de novo lipid synthesis. Fatty acids are required for the production of phosphoglycerides, which, together with cholesterol, can be used for building cell membranes. Tria-cylglycerides and cholesterylesters are stored in lipid droplets ...
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[PDF File]Cholesterol and Cancer, in the Balance Sandrine Silvente ...
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Ribas et al. Clin Trans Med 0 DOI 10.1186/s40169-016-0106-5 REVIEW Mitochondria, cholesterol and cancer cell metabolism Vicent Ribas1,2, Carmen García‑Ruiz1,2,3 and José C. Fernández‑Checa1 ...
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[PDF File]Targeting Lipid Metabolism in Cancer
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DOI: 10.1126/science.1252787 Science 343, 1445 (2014); Sandrine Silvente-Poirot and Marc Poirot Cholesterol and Cancer, in the Balance This copy is for your personal, non-commercial use only.
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Emerging roles of lipid metabolism in cancer metastasis
Regulation of lipid metabolism in breast cancer provides diagnostic and therapeutic opportunities Cancer cells are characterized by extensive metabolic changes, since the rapid growth of tumors leads to lack of oxygen and hypoxia in the cells. One crucial feature is also the Warburg effect, a process in …
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Lipid metabolism in cancer - FEBS Press
cancers Review Cholesterol Metabolism: A Potential Therapeutic Target in Glioblastoma Fahim Ahmad †, Qian Sun †, Deven Patel and Jayne M. Stommel * National Institutes of Health, National Cancer Institute, Radiation Oncology Branch, Bethesda, MD 20892, USA;
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[PDF File]Mitochondria, cholesterol and cancer cell metabolism
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ities in cancer cells have received less concern but are increasingly being recognized in the past few years [6–8]. Lipids are composed of fat (triglyceride, TG) and lipoid (phospholipid, cholesterol and cholesterol ester). Lipid metabolism involves the process of lipid synthesis, storage and degradation. The major component of cell membrane
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[PDF File]Obesity, Cholesterol Metabolism, and Breast Cancer ...
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linking cholesterol metabolism to breast can-cer may provide some insights. Cetrain cho-lesterol metabolites can promote ( 1, 2) or sup-press ( 3) breast cancer . This raises the impor - tant question of ho w to regulate or inhibit the cholesterol metabolic pathawy, and at which steps, in a therapeutic approach to cancer .
cholesterol metabolism review

[PDF File]The Role of Cholesterol in Cancer
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Perspective Obesity, Cholesterol Metabolism, and Breast Cancer Pathogenesis Donald P. McDonnell1, Sunghee Park1, Matthew T. Goulet1, Jeff Jasper1, Suzanne E. Wardell1, Ching-yi Chang 1, John D. Norris , John R. Guyton2, and Erik R. Nelson3 Abstract Obesity and altered lipid metabolism are risk factors for breast cancer in pre- and post-menopausal women.
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Cholesterol metabolism in cancer