Propofol infusion syndrome in adults

    • [DOC File]ICU SEDATION GUIDELINES

      https://info.5y1.org/propofol-infusion-syndrome-in-adults_1_882c78.html

      The largest series describing propofol infusion syndrome reports that it occurs at doses greater than 83 mcg/kg/minute for greater than 24 hours (35). This is well above the usual clinical dose, even for TBI. High-dose propofol should, therefore, be utilized with caution.

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    • [DOCX File]Severe Traumtic Brain Injury

      https://info.5y1.org/propofol-infusion-syndrome-in-adults_1_263b98.html

      propofol infusions (>83 mcg/kg/min for greater than 24 hours) have been associated with fatal acidosis, rhabdomyolysis, and refractory arrhythmias (known as “Propofol Infusion Syndrome”) (42). In general, doses ≤ 50 mcg/kg/min are both effective and safe.

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    • wiki.med.umich.edu

      NOTE: Propofol infusion syndrome is a very rare complication that has been reported in the status literature, likely due to the common practice of using extremely high propofol doses for prolonged periods in these patients.

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    • [DOCX File]Explanations

      https://info.5y1.org/propofol-infusion-syndrome-in-adults_1_e6d03c.html

      little evaluation of propofol infusion syndrome with potential risk of a large-scale change to much greater propofol use. Given modest benefits of propofol in meta-analysis and their questionable clinical significance, a small increase in PRIS would reverse potential propofol …

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    • [DOC File]Propofol Dosing Guidelines

      https://info.5y1.org/propofol-infusion-syndrome-in-adults_1_930dbb.html

      D. Titrate the propofol infusion rate, not the ketamine infusion rate. If the patient seems to require a lot of propofol, give 25-50 µg fentanyl boluses. F. As with propofol, the ketamine infusion rate was designed for adults of average weight (60-80 kg). Adjust upward or downward for larger or smaller patients.

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    • [DOCX File]Home Page: British Journal of Anaesthesia

      https://info.5y1.org/propofol-infusion-syndrome-in-adults_1_5bcf6f.html

      Liolios A, Guerit JM, Scholtes JL, Raftopoulos C, Hantson P. Propofol infusion syndrome associated with short-term large-dose infusion during surgical anesthesia in …

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