Propofol infusion syndrome in adults
[DOC File]ICU SEDATION GUIDELINES
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The largest series describing propofol infusion syndrome reports that it occurs at doses greater than 83 mcg/kg/minute for greater than 24 hours (35). This is well above the usual clinical dose, even for TBI. High-dose propofol should, therefore, be utilized with caution.
[DOCX File]Severe Traumtic Brain Injury
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propofol infusions (>83 mcg/kg/min for greater than 24 hours) have been associated with fatal acidosis, rhabdomyolysis, and refractory arrhythmias (known as “Propofol Infusion Syndrome”) (42). In general, doses ≤ 50 mcg/kg/min are both effective and safe.
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NOTE: Propofol infusion syndrome is a very rare complication that has been reported in the status literature, likely due to the common practice of using extremely high propofol doses for prolonged periods in these patients.
[DOCX File]Explanations
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little evaluation of propofol infusion syndrome with potential risk of a large-scale change to much greater propofol use. Given modest benefits of propofol in meta-analysis and their questionable clinical significance, a small increase in PRIS would reverse potential propofol …
[DOC File]Propofol Dosing Guidelines
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D. Titrate the propofol infusion rate, not the ketamine infusion rate. If the patient seems to require a lot of propofol, give 25-50 µg fentanyl boluses. F. As with propofol, the ketamine infusion rate was designed for adults of average weight (60-80 kg). Adjust upward or downward for larger or smaller patients.
[DOCX File]Home Page: British Journal of Anaesthesia
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Liolios A, Guerit JM, Scholtes JL, Raftopoulos C, Hantson P. Propofol infusion syndrome associated with short-term large-dose infusion during surgical anesthesia in …
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