Statin induced autoimmune myopathy treatment
Rockefeller University
Maria Patricia ManingatPAM-0655 - Quality of Life and Metabolic Alterations in Patients with Statin-Associated Myopathy . Martin MarkowitzMMA-0597 - A Phase 2, Open-Label, Multicenter Study of the Safety of Ritonavir-Boosted GS-9137 (GS-9137/r) Administered in Combination with Other Antiretroviral Agents for the Treatment of HIV-1 Infected Subjects
[DOCX File]MRCP Notes Compilation - Nigel Fong - Notes Site - Home
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Myopathy -- small complexes: ... It usually presents in childhood with failure to thrive, or in adulthood with renal colic. A major etiology is autoimmune disease (Sjoren’s, RA). Treatment is with potassium citrate. ... presents with exercise-induced muscle pain and stiffness with contractures that subside at …
[DOC File]Topic: Preoperative Risk Assessment and Risk Reduction ...
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Side effect such as statin-induced myopathy (muscle damage) and rhabdomyolysis (muscle destruction) are a major concern, but the potential benefit of perioperative statin therapy appear to outweigh the risk of potential hazard. Therapy should be initiated a few days before surgery in combination with dose adjustment for tight heart rate control.
[DOCX File]Attachment 1. Product Information for Atozet/Zeteze
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There have been rare reports of immune-mediated necrotizing myopathy (IMNM), an autoimmune myopathy, associated with statin use. IMNM is characterised by: proximal muscle weakness and elevated serum creatinine kinase, which persist despite discontinuation of statin treatment; muscle biopsy showing necrotizing myopathy without significant ...
[DOCX File]Title: Statin Induced Autoimmune Myopathy
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Statin-induced autoimmune myositis remains a rare (and likely new) subset of the statin-induced myopathy spectrum. As such, presentation, response to treatment and long-term prognosis remain incompletely defined and the evidence base for best- practice treatment is lacking.
[DOC File]Neuromuscular Questions
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Autoimmune disorder. Associated with postsynaptic antibodies. Proximal weakness. Increment of CMAP with 50hz stimulation. The following are true of Nemaline myopathy except: Congenital hypotonia. Progressive weakness. Normal intelligence. Normal extra-ocular muscles. T or F In Duchene MD treatment with prednisone has prolonged ambulation . by 2 ...
[DOCX File]Australian public assessment report for Ezetimibe ...
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The most frequent treatment-related AEs with co-administration of ezetimibe with a statin were myalgia, headache, fatigue, nausea, abdominal pain, diarrhoea and increased liver enzymes. Compared to statin monotherapy, the most notable risk was increased hepatic transaminases (increased ALT: 1.7% versus 0.6% and increased AST: 1.4% versus 0.4%).
[DOC File]International Journal of Biological Sciences
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Moreover, Statin-induced myopathy is caused by the long-term use of higher doses, when certain drugs have been used previously (cyclosporine, erythromycin and clarithromycin), we should be fully aware of toxic side effects and other drug interactions and monitor for adverse reactions.
[DOCX File]University of Manchester
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The patient has the features of a statin-induced immune-mediated necrotizing myopathy (IMNM), recently described as being associated with the anti-HMGCR antibody. First-line immunotherapy with glucocorticoids is appropriate while further investigations are undertaken, although many cases of IMNM ultimately require more aggressive immunotherapy.
[DOCX File]Hawkes N (2017). NICE guidelines could put 12 million UK ...
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Statin-induced myopathy has been associated with low CoEQ10 levels (Banach et al 2014), but research into the impact of CoEQ10 supplementation has failed to demonstrate improved tolerance. Therefore, this has not been approved by NICE as a co-prescribing strategy to address myopathy (NICE 2016).
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